title: Paternal Age Is Not Associated With Pregnancy Outcomes After Single Thawed Euploid Blastocyst Transfer.
abstract: Although controversial, increasing paternal age has been shown to negatively affect assisted reproductive technology (ART) outcomes and success rates. Most studies investigating the effect of paternal age on ART outcomes use a donor oocyte model to minimize maternal aneuploidy contribution. This study sought to determine whether increasing paternal age is associated with adverse in vitro fertilization (IVF) outcomes when aneuploidy is minimized using preimplantation genetic screening. There were 573 single thawed euploid embryo transfers from 473 patients undergoing oocyte donor and autologous IVF cycles. Cycles were categorized according to paternal age at oocyte retrieval, and an age adjustment was performed for maternal age in order to evaluate for an isolated paternal age effect. Fertilization rate was found to decrease significantly with increasing paternal age ( P = .04). After controlling for oocyte age, there was no significant difference in pregnancy outcomes across all paternal age categories after euploid embryo transfer, including implantation rate ( P = .23), clinical pregnancy rate ( P = .51), and spontaneous abortion rate ( P = .55). Therefore, if a couple is able to produce and transfer a single thawed euploid embryo, no difference in IVF pregnancy outcomes is identified with increasing paternal age.
authors.affiliation: 1 Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Ashley W
authors.initials: AW
authors.lastname: Tiegs
authors.affiliation: 2 Department of Reproductive Endocrinology and Infertility, New York University Fertility Center, New York, NY, USA.
authors.forename: Nidhee M
authors.initials: NM
authors.lastname: Sachdev
authors.affiliation: 2 Department of Reproductive Endocrinology and Infertility, New York University Fertility Center, New York, NY, USA.|3 Department of Obstetrics and Gynecology, New York University Fertility Center, New York, NY, USA.
authors.forename: Jamie A
authors.initials: JA
authors.lastname: Grifo
authors.affiliation: 4 Department of New York University Fertility Center, New York, NY, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: McCulloh
authors.affiliation: 3 Department of Obstetrics and Gynecology, New York University Fertility Center, New York, NY, USA.|5 Department of Oocyte Donation Program, New York University Fertility Center, New York, NY, USA.
authors.forename: Frederick
authors.initials: F
authors.lastname: Licciardi
mesh_terms: D000328:Adult; D000367:Age Factors; D010064:Embryo Implantation / Q000502:physiology; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054315:Oocyte Retrieval; D010331:Paternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis
keywords: assisted reproductive technology (ART) outcomes; euploid embryo transfer; paternal age; preimplantation genetic screening