title: Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants.
abstract: Mothers of preterm infants often are at risk of expressing an inadequate amount of milk for their infants and the use of galactogogues is often considered. Domperidone is a widely used galactogogue with little information available to guide clinicians regarding initiation, timing, and duration of treatment. Research aim: The primary objective of this study was to determine whether administration of domperidone within the first 21 days after delivery would lead to a higher proportion of mothers achieving a 50% increase in the volume of milk at the end of 14 days of treatment compared with mothers receiving placebo.
  
  
  
  Eligible mothers were randomized to one of two treatment arms: Group A-domperidone 10 mg orally three times daily for 28 days; or Group B-placebo 10 mg orally three times daily for 14 days followed by domperidone 10 mg orally three times daily for 14 days.
  
  
  
  A total of 90 mothers of infants ≤ 29 weeks gestation were randomized. Mean milk volumes at entry were similar for both groups. More mothers achieved a 50% increase in milk volume after 14 days in Group A (77.8%) compared with Group B (57.8%), odds ratio = 2.56, 95% confidence interval [1.02, 6.25], p = .04.
  
  
  
  A greater number of mothers experienced a 50% or more increase in human milk volume, but the absolute increase in milk volume was modest.
authors.affiliation: Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
authors.forename: Elizabeth V
authors.initials: EV
authors.lastname: Asztalos
authors.affiliation: Izaak Walton Killam Health Centre, Dalhousie University, Halifax, NS, Canada.
authors.forename: Marsha
authors.initials: M
authors.lastname: Campbell-Yeo
authors.affiliation: Perinatal and Women's Health, London Health Sciences Centre, Western University, London, ON, Canada.
authors.forename: Orlando P
authors.initials: OP
authors.lastname: da Silva
authors.affiliation: Division of Clinical Pharmacology & Toxicology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Shinya
authors.initials: S
authors.lastname: Ito
authors.affiliation: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
authors.forename: Alex
authors.initials: A
authors.lastname: Kiss
authors.affiliation: School of Pharmacy, University of Waterloo, Kitchener, ON, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Knoppert
authors.affiliation: Christoph Fusch; Lajos Kovacs; Annie Janvier; Georges Cauoette; Abhay Lodha; Barbara Bulleid; Doug McMillan; Balpreet Singh
mesh_terms: D000328:Adult; D001942:Breast Feeding / Q000379:methods* / Q000706:statistics & numerical data; D004294:Domperidone / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D056669:Galactogogues / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism; D007774:Lactation / Q000187:drug effects*; D008895:Milk, Human / Q000187:drug effects*; D009035:Mothers / Q000706:statistics & numerical data
chemical_list: D056669:Galactogogues; D004294:Domperidone
keywords: breast milk expression; breastfeeding; galactogogues; human milk; human milk production; lactation difficulties; milk supply; randomized controlled trials