title: Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity.
abstract: OBJECTIVE
  To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder.
  
  
  METHODS
  A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review.
  
  
  RESULTS
  One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated.
  
  
  CONCLUSIONS
  Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.
authors.affiliation: Director, Neuropsychiatry Division, Dent Neurologic Institute, Buffalo, New York, USA.
authors.forename: Horacio A
authors.initials: HA
authors.lastname: Capote
authors.affiliation: Clinical Pharmacist, Research Division, Dent Neurologic Institute, Buffalo, New York, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Rainka
authors.affiliation: Research Associate, Dent Neurologic Institute, Buffalo, New York, USA.
authors.forename: Erica S
authors.initials: ES
authors.lastname: Westphal
authors.affiliation: Research Intern, Dent Neurologic Institute, Buffalo, New York, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Beecher
authors.affiliation: Director of Research Division, Dent Neurologic Institute, Buffalo, New York, USA.
authors.forename: Francis M
authors.initials: FM
authors.lastname: Gengo
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D007211:Indoles; C046649:ropinirole
keywords: BISS; YMRS; bipolar; dopamine agonists; mania; ropinirole