title: Novel genetic loci associated with hippocampal volume.
abstract: The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
authors.affiliation: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
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authors.affiliation: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Department of Psychiatry, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
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authors.affiliation: NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.|Department of Research and Development, Diakonhjemmet Hospital, 0319 Oslo, Norway.
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authors.affiliation: Max Planck Institute of Psychiatry, 80804 Munich, Germany.
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authors.affiliation: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
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authors.affiliation: Department of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark.|The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK-8000 Aarhus and Copenhagen, Denmark.|Center for integrated Sequencing, iSEQ, Aarhus University, DK-8000 Aarhus, Denmark.
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authors.identifier: 0000-0002-8442-493X
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authors.affiliation: Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.|Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.|Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
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authors.affiliation: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
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authors.affiliation: Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK.|Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, 3060, Switzerland.
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authors.affiliation: Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.|Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK.|The Jenner Institute Laboratories, University of Oxford, Oxford OX3 7DQ, UK.
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authors.affiliation: Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Karakter Child and Adolescent Psychiatry University Center, Nijmegen, 6525 GC, The Netherlands.
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authors.affiliation: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
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authors.affiliation: Department of Psychiatry, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Karakter Child and Adolescent Psychiatry University Center, Nijmegen, 6525 GC, The Netherlands.
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authors.affiliation: Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.|Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.|Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
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authors.initials: NA
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authors.affiliation: Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.|Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
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authors.affiliation: Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, 3502, Australia.|Centre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, 3502, Australia.|Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
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authors.affiliation: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: Li
authors.identifier: 0000-0002-5443-0503
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authors.affiliation: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, 6525 EN, The Netherlands.
authors.forename: Elena
authors.initials: E
authors.lastname: Shumskaya
authors.affiliation: Icelandic Heart Association, Kopavogur, 201, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
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authors.initials: AV
authors.lastname: Smith
authors.affiliation: Department of Psychiatry, Yale University, New Haven, Connecticut 06511, USA.|Olin Neuropsychiatric Research Center, Hartford, Connecticut 06114, USA.|Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
authors.forename: Emma
authors.initials: E
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authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.|Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.
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authors.initials: LT
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authors.affiliation: Institute for Community Medicine, University Medicine Greifswald, 17489 Greifswald, Germany.
authors.forename: Alexander
authors.identifier: 0000-0002-8309-094X
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authors.affiliation: CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.|Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL, Santander, Cantabria, 39011, Spain.
authors.forename: Diana
authors.initials: D
authors.lastname: Tordesillas-Gutierrez
authors.affiliation: Institut Pasteur, 75015 Paris, France.
authors.forename: Roberto
authors.initials: R
authors.lastname: Toro
authors.affiliation: Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.|Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
authors.forename: Daniah
authors.identifier: 0000-0003-4826-9570
authors.initials: D
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authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
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authors.initials: S
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authors.affiliation: GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287, USA.
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authors.initials: D
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authors.affiliation: Department of Radiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
authors.forename: Jeroen
authors.initials: J
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authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
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authors.identifier: 0000-0003-1606-8643
authors.initials: SJ
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authors.affiliation: Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands.
authors.forename: Dennis
authors.initials: D
authors.lastname: Van der Meer
authors.affiliation: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
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authors.initials: MMJ
authors.lastname: Van Donkelaar
authors.affiliation: Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, 3584 CG Utrecht, The Netherlands.
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authors.initials: KR
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authors.affiliation: Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California 92617, USA.
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authors.initials: TGM
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authors.affiliation: Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands.
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authors.initials: D
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authors.affiliation: Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, 01307 Dresden, Germany.|Department of Psychology, Georgia State University, Atlanta, Georgia 30302, USA.
authors.forename: Esther
authors.initials: E
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authors.affiliation: NORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.|Department of Psychology, Georgia State University, Atlanta, Georgia 30302, USA.
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authors.identifier: 0000-0001-8644-956X
authors.initials: LT
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authors.affiliation: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.|The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Whelan
authors.affiliation: NORMENT-KG Jebsen Centre, Department of Psychology, University of Oslo, 0317 Oslo, Norway.
authors.forename: Beverly G
authors.initials: BG
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authors.affiliation: Department of Psychiatry, Yale University, New Haven, Connecticut 06511, USA.|Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, 39216, USA.
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authors.identifier: 0000-0002-4169-9781
authors.initials: AM
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authors.affiliation: Department of Psychiatry, University Medicine Greifswald, 17489 Greifswald, Germany.|FMRIB Centre, University of Oxford, Oxford OX3 9DU, UK.
authors.forename: Katharina
authors.initials: K
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authors.affiliation: Human Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.
authors.forename: Girma
authors.initials: G
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authors.affiliation: German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 17487 Greifswald, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Wolf
authors.affiliation: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
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authors.initials: T
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authors.affiliation: GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287, USA.
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Yanek
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.|University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, 97080, Germany.
authors.forename: Jingyun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.
authors.forename: Alex
authors.initials: A
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authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, 6525 EN, The Netherlands.
authors.forename: Marcel P
authors.initials: MP
authors.lastname: Zwiers
authors.affiliation: NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.|Department of Research and Development, Diakonhjemmet Hospital, 0319 Oslo, Norway.|Biospective Inc, Montreal, Quebec, Canada, 6100 Avenue Royalmount, Montréal, Québec, Canada H4P 2R2.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Agartz
authors.affiliation: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.|South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville/Edinburg/San Antonio, Texas, 78250, USA.|Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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authors.initials: L
authors.lastname: Almasy
authors.affiliation: Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 29104, USA.|National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Victoria 3052, Australia.
authors.forename: David
authors.initials: D
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authors.affiliation: Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France.
authors.forename: Philippe
authors.identifier: 0000-0001-9088-234X
authors.initials: P
authors.lastname: Amouyel
authors.affiliation: NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.|NORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.
authors.forename: Ole A
authors.identifier: 0000-0002-4461-3568
authors.initials: OA
authors.lastname: Andreassen
authors.affiliation: Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
authors.forename: Sampath
authors.initials: S
authors.lastname: Arepalli
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Amelia A
authors.initials: AA
authors.lastname: Assareh
authors.affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center, 639 West 1168th Street, New York, New York 10032, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Barral
authors.affiliation: Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.|Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.|Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
authors.forename: Mark E
authors.initials: ME
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authors.affiliation: GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287, USA.
authors.forename: Diane M
authors.initials: DM
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authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Becker
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.|University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, 97080, Germany.
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
authors.affiliation: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.affiliation: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: van Bokhoven
authors.affiliation: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.|Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, 3501 Forbes Ave., Suite 830, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Henry
authors.identifier: 0000-0001-9487-6617
authors.initials: H
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authors.affiliation: Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Brouwer
authors.affiliation: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Dementia Collaborative Research Centre-Assessment and Better Care, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Han G
authors.initials: HG
authors.lastname: Brunner
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Department of Clinical Genetics and GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
authors.forename: Randy L
authors.initials: RL
authors.lastname: Buckner
authors.affiliation: Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Karakter Child and Adolescent Psychiatry University Center, Nijmegen, 6525 GC, The Netherlands.
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authors.initials: JK
authors.lastname: Buitelaar
authors.affiliation: Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA.
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authors.initials: KB
authors.lastname: Bulayeva
authors.affiliation: Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
authors.forename: Wiepke
authors.initials: W
authors.lastname: Cahn
authors.affiliation: Department of Evolution and Genetics, Dagestan State University, Makhachkala 367000, Dagestan, Russia.|The Mind Research Network & LBERI, Albuquerque, New Mexico 87106, USA.
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.affiliation: Human Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.|Department of ECE, University of New Mexico, Albuquerque, New Mexico 87131, USA.
authors.forename: Dara M
authors.initials: DM
authors.lastname: Cannon
authors.affiliation: The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
authors.forename: Gianpiero L
authors.initials: GL
authors.lastname: Cavalleri
authors.affiliation: Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore.|Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.|Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.|Division of Medical Genetics, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.|Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.affiliation: Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
authors.forename: Mark R
authors.initials: MR
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authors.affiliation: Psychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College, Dublin, Dublin 2, Ireland.
authors.forename: Aiden
authors.initials: A
authors.lastname: Corvin
authors.affiliation: Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, 39008 Santander, Spain.|CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
authors.affiliation: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Curran
authors.affiliation: Max Planck Institute of Psychiatry, 80804 Munich, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Czisch
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany.|Center for Multimodal Imaging and Genetics, University of California, San Diego, California 92093, USA.
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authors.initials: AM
authors.lastname: Dale
authors.affiliation: Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, California 92093, USA.
authors.forename: Gareth E
authors.initials: GE
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authors.affiliation: Avera Institute for Human Genetics, Sioux Falls, South Dakota 57108, USA.
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authors.initials: AJM
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authors.affiliation: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
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authors.initials: EJC
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authors.affiliation: Harvard Medical School, Boston, Massachusetts 02115, USA.|Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.|Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.|Harvard Medical School, Boston, Massachusetts, 02115, USA.|Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, 02142, USA.
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authors.initials: PL
authors.lastname: De Jager
authors.affiliation: Broad Institute, Cambridge, Massachusetts, 02142, USA.
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authors.initials: GI
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authors.affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Deary
authors.affiliation: INSERM Unit U1219, University of Bordeaux, 33076 Bordeaux, France.|Department of Neurology, Boston University School of Medicine, Boston, Massachusetts,02118, USA.|Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia.
authors.forename: Stéphanie
authors.initials: S
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authors.affiliation: Department of Neurology, Bordeaux University Hospital, Bordeaux, 33076, France.
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
authors.affiliation: The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.|Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, 4860 Y Street, Suite 3700, Sacramento, California 95817, USA.
authors.forename: Norman
authors.initials: N
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authors.affiliation: Neurology Division, Beaumont Hospital, Dublin 9, Ireland.
authors.forename: Chantal
authors.initials: C
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authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118 USA.|Framingham Heart Study, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703 USA.
authors.forename: Anita
authors.initials: A
authors.lastname: DeStefano
authors.affiliation: Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
authors.forename: Allissa
authors.initials: A
authors.lastname: Dillman
authors.affiliation: NORMENT-KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.|Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, 1070 Brussels, Belgium.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Djurovic
authors.affiliation: Department of Medical Genetics, Oslo University Hospital, 0420 Oslo, Norway.|Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, H91 TK33, Galway, Ireland.
authors.forename: Gary
authors.initials: G
authors.lastname: Donohoe
authors.affiliation: Human Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.|Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland.
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Drevets
authors.affiliation: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Ravi
authors.initials: R
authors.lastname: Duggirala
authors.affiliation: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Thomas D
authors.identifier: 0000-0002-5809-1190
authors.initials: TD
authors.lastname: Dyer
authors.affiliation: Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
authors.forename: Christian
authors.initials: C
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authors.affiliation: Janssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
authors.forename: Susanne
authors.initials: S
authors.lastname: Erk
authors.affiliation: NORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.|Department of Psychology, Georgia State University, Atlanta, Georgia 30302, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Espeseth
authors.affiliation: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
authors.forename: Iryna O
authors.initials: IO
authors.lastname: Fedko
authors.affiliation: Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
authors.forename: Guillén
authors.initials: G
authors.lastname: Fernández
authors.affiliation: Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Department of Psychiatry and Psychotherapy, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Language and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 XD Nijmegen, The Netherlands.
authors.forename: Simon E
authors.identifier: 0000-0002-3132-1996
authors.initials: SE
authors.lastname: Fisher
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.|Intramural Research Program of the National Institute on Aging, Baltimore, Maryland, 21224, USA.
authors.forename: Debra A
authors.initials: DA
authors.lastname: Fleischman
authors.affiliation: Department of Neurological Sciences & Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60616, USA.
authors.forename: Ian
authors.initials: I
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authors.affiliation: Robertson Centre for Biostatistics, University of Glasgow, Glasgow, G41 4DQ, UK.
authors.forename: Myriam
authors.initials: M
authors.lastname: Fornage
authors.affiliation: Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA.
authors.forename: Tatiana M
authors.initials: TM
authors.lastname: Foroud
authors.affiliation: Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.|Language and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 XD Nijmegen, The Netherlands.
authors.forename: Clyde
authors.initials: C
authors.lastname: Francks
authors.affiliation: University of Texas Health Science Center, San Antonio, Texas 78229, USA.
authors.forename: Masaki
authors.initials: M
authors.lastname: Fukunaga
authors.affiliation: Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.|Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
authors.forename: J Raphael
authors.initials: JR
authors.lastname: Gibbs
authors.affiliation: Department of Psychiatry, Yale University, New Haven, Connecticut 06511, USA.|Olin Neuropsychiatric Research Center, Hartford, Connecticut 06114, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Glahn
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.|Harvard Medical School, Boston, Massachusetts 02115, USA.
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authors.initials: RL
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authors.affiliation: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Harald H H
authors.initials: HHH
authors.lastname: Göring
authors.affiliation: Harvard Medical School, Boston, Massachusetts 02115, USA.|Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, 444-8585, Japan.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Green
authors.affiliation: Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, 69120, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Gruber
authors.affiliation: Icelandic Heart Association, Kopavogur, 201, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
authors.forename: Vilmundur
authors.initials: V
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authors.affiliation: Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Guelfi
authors.affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.|Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway.
authors.forename: Asta K
authors.initials: AK
authors.lastname: Håberg
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.|Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.
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authors.initials: NK
authors.lastname: Hansell
authors.affiliation: Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.affiliation: Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands.
authors.forename: Catharina A
authors.initials: CA
authors.lastname: Hartman
authors.affiliation: Department of Radiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, 7030, Norway.|Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
authors.forename: Ryota
authors.identifier: 0000-0002-5941-4238
authors.initials: R
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authors.affiliation: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, 565-0871, Japan.
authors.forename: Katrin
authors.initials: K
authors.lastname: Hegenscheid
authors.affiliation: Janssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.affiliation: NORMENT-KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.|Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
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authors.affiliation: German Center for Neurodegenerative Diseases (DZNE), Tübingen, 72076, Germany.
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authors.initials: DJ
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authors.affiliation: Max Planck Institute of Psychiatry, 80804 Munich, Germany.|Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242, USA.
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authors.initials: CR
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authors.affiliation: NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.|Biospective Inc, Montreal, Quebec, Canada, 6100 Avenue Royalmount, Montréal, Québec, Canada H4P 2R2.
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authors.initials: R
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authors.affiliation: Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK.
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authors.initials: I
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authors.initials: JB
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authors.affiliation: Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK.
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authors.affiliation: Human Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.|School of Medical Sciences, UNSW, Sydney, New South Wales 2052, Australia.
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authors.initials: X
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authors.affiliation: INSERM UMR 1000 "Neuroimaging and Psychiatry", Service Hospitalier Frédéric Joliot; University Paris-Sud, Université Paris-Saclay, University Paris Descartes, Maison de Solenn, Paris, 91400, France.
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authors.initials: DL
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authors.initials: OL
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authors.affiliation: Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.|Departments of Neurology and Psychiatry, University of Pittsburgh, 3501 Forbes Ave., Suite 830, Pittsburgh Pennsylvania 15213, USA.
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authors.initials: S
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authors.affiliation: Department of Neurology, Bordeaux University Hospital, Bordeaux, 33076, France.
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authors.initials: O
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authors.affiliation: Neuroscience Research Australia, Sydney, New South Wales 2031, Australia.
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authors.initials: JL
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authors.affiliation: Lieber Institute for Brain Development, Baltimore, Maryland 21205, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.|Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.
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authors.initials: VS
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authors.initials: C
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authors.affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK.
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authors.identifier: 0000-0002-0198-4588
authors.initials: AM
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authors.initials: KL
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authors.forename: Patrizia
authors.initials: P
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authors.affiliation: NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.|NORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.
authors.forename: Ingrid
authors.initials: I
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authors.affiliation: Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, 68159 Mannheim, Germany.
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authors.initials: A
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authors.affiliation: Janssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
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authors.initials: GW
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authors.affiliation: Department of Medical Genetics, Oslo University Hospital, 0420 Oslo, Norway.
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authors.initials: DW
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authors.affiliation: NORMENT-KG Jebsen Centre, Department of Psychology, University of Oslo, 0317 Oslo, Norway.
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authors.initials: TH
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authors.affiliation: Division of Medical Genetics, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.|Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
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authors.initials: TW
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authors.affiliation: Max Planck Institute of Psychiatry, 80804 Munich, Germany.|Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, 06132 Perugia, Italy.|Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
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authors.initials: B
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authors.affiliation: Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
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authors.initials: MA
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authors.affiliation: University of Liverpool, Institute of Translational Medicine, Liverpool L69 3BX, UK.|Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17489 Greifswald, Germany.
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authors.initials: M
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authors.affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, 39216, USA.|German Center for Cardiovascular Research (DZHK e.V.), partner site Greifswald, Greifswald, 17475, Germany.
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authors.identifier: 0000-0002-4516-5103
authors.initials: TE
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authors.affiliation: Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.|Department of Statistics & WMG, University of Warwick, Coventry CV4 7AL, UK.|Department of Medical Informatics Erasmus MC, 3015 CE Rotterdam, The Netherlands.
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authors.initials: WJ
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authors.affiliation: Division of Medical Genetics, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.|Faculty of Applied Sciences, Delft University of Technology, Delft, 2628 CD, The Netherlands.
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authors.initials: MM
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authors.affiliation: Department of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
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authors.initials: L
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authors.initials: K
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authors.initials: RL
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authors.affiliation: Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.|Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA.
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authors.initials: RA
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authors.affiliation: Neurology Division, Beaumont Hospital, Dublin 9, Ireland.
authors.forename: Massimo
authors.initials: M
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authors.affiliation: Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.|Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada M6A 2E1.|Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada M5T 1R8.
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authors.initials: T
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authors.forename: Zdenka
authors.initials: Z
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authors.affiliation: Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
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authors.initials: BWJH
authors.lastname: Penninx
authors.affiliation: Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2.|Department of Radiology, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
authors.forename: G Bruce
authors.identifier: 0000-0001-8924-683X
authors.initials: GB
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authors.affiliation: Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California 92617, USA.
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authors.initials: SG
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authors.affiliation: Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
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authors.initials: BM
authors.lastname: Psaty
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.|Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, USA Group Health Research Institute, Group Health, 1730 Minor Avenue/Suite 1360, Seattle, Washington 98101, USA.
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authors.initials: S
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authors.affiliation: Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, 68159 Mannheim, Germany.
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authors.initials: M
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authors.initials: JL
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authors.affiliation: Janssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
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authors.initials: N
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authors.affiliation: Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.|Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK.
authors.forename: Mina
authors.initials: M
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authors.affiliation: John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.|Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.|Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.|Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
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authors.initials: RL
authors.lastname: Sacco
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.|Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
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authors.identifier: 0000-0002-9595-3220
authors.initials: PS
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authors.affiliation: Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.|Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA.
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authors.identifier: 0000-0002-1376-8532
authors.initials: AJ
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authors.initials: R
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authors.affiliation: Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.
authors.forename: Helena
authors.initials: H
authors.lastname: Schmidt
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, 55905, USA.|Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, 21228, USA.
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authors.identifier: 0000-0003-2967-9662
authors.initials: PR
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authors.initials: S
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authors.affiliation: Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21/III, 8010 Graz, Austria.|Department of Neuroimaging, Institute of Psychiatry, King's College London, London SE5 8AF, UK.|Biomedical Research Centre for Mental Health, King's College London, London SE5 8AF, UK.
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authors.initials: A
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authors.affiliation: Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
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authors.initials: A
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authors.affiliation: UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, SL9 0RJ, UK.
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authors.initials: C
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authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Harvard Medical School, Boston, Massachusetts 02115, USA.|Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts 02141, USA.
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authors.initials: JW
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authors.affiliation: MRC Edinburgh Brain Bank, University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences, Edinburgh, EH16 4SB UK.|Institute of Clinical Medicine, Neurology, University of Eastern Finland, FI-70211 Kuopio, Finland.
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authors.initials: H
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authors.affiliation: NORMENT-KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.|Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
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authors.initials: VM
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authors.initials: DJ
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authors.affiliation: Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK.
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authors.initials: JE
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authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
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authors.initials: A
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authors.affiliation: Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, G4 0SF, UK.
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authors.initials: AW
authors.lastname: Toga
authors.affiliation: Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
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authors.initials: BJ
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authors.affiliation: INSERM Unit U1219, University of Bordeaux, 33076 Bordeaux, France.|3rd Department of Neurology, "G. Papanicolaou", Hospital, Aristotle University of Thessaloniki, Thessaloniki, 57010, Greece.
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authors.initials: C
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authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.|Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219, Bordeaux, F-33000, France.
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authors.initials: AG
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authors.affiliation: Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.|Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.|Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
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authors.initials: MCV
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authors.affiliation: Department of Internal Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
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authors.initials: M
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authors.affiliation: Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
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authors.initials: A
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authors.affiliation: Genentech Inc., South San Francisco, California 94080, USA.
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authors.initials: NJA
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authors.initials: NEM
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authors.affiliation: Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
authors.forename: Dennis
authors.initials: D
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authors.affiliation: Department of Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
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authors.initials: MJ
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authors.affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center, 639 West 1168th Street, New York, New York 10032, USA.
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authors.initials: BN
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authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Neuroscience, 9713 AW Groningen, the Netherlands.
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authors.initials: DJ
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authors.forename: Henry
authors.initials: H
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authors.affiliation: Janssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
authors.forename: Henrik
authors.initials: H
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authors.affiliation: Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.|Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.|Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
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authors.identifier: 0000-0002-9812-6642
authors.initials: JM
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authors.initials: TH
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authors.affiliation: Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK.
authors.forename: Michael E
authors.initials: ME
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authors.affiliation: Lieber Institute for Brain Development, Baltimore, Maryland 21205, USA.|Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
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authors.initials: DR
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authors.affiliation: Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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authors.initials: MW
authors.lastname: Weiner
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.|Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
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authors.initials: W
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authors.affiliation: Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California, San Francisco, California 94121, USA.
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authors.identifier: 0000-0002-3115-2977
authors.initials: E
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authors.affiliation: Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.|Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-141 57 Huddinge, Sweden.
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authors.initials: T
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authors.affiliation: Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore.|Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.|Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
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authors.lastname: Wong
authors.affiliation: Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.|Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.|Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
authors.forename: Clinton B
authors.initials: CB
authors.lastname: Wright
authors.affiliation: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
authors.forename: Ronald H
authors.initials: RH
authors.lastname: Zielke
authors.affiliation: Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, 3015 CE Rotterdam, The Netherlands.
authors.forename: Alan B
authors.initials: AB
authors.lastname: Zonderman
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Van Duijn
authors.affiliation: Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.|Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Wright
authors.affiliation: Laboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: W T
authors.initials: WT
authors.lastname: Longstreth
authors.affiliation: MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
authors.forename: Gunter
authors.initials: G
authors.lastname: Schumann
authors.affiliation: Department of Psychiatry, University Medicine Greifswald, 17489 Greifswald, Germany.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Grabe
authors.affiliation: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Department of Psychiatry, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.|Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
authors.forename: Barbara
authors.identifier: 0000-0003-4375-6572
authors.initials: B
authors.lastname: Franke
authors.affiliation: Departments of Neurology and Epidemiology, University of Washington, 325 Ninth Avenue, Seattle, Washington 98104-2420, USA.
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Medland
authors.affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts,02118, USA.|Framingham Heart Study, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703 USA.
authors.forename: Sudha
authors.initials: S
authors.lastname: Seshadri
authors.affiliation: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.|Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.|Intramural Research Program, NIA, NIH, 7201 Wisconsin Ave, Suite 3C-309, Bethesda, Maryland 20892, USA.
authors.forename: M Arfan
authors.initials: MA
authors.lastname: Ikram
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology; D002648:Child; D015331:Cohort Studies; D018819:Dipeptidyl Peptidase 4 / Q000235:genetics; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006023:Glycoproteins / Q000235:genetics; D006624:Hippocampus / Q000254:growth & development*; D006801:Humans; D008297:Male; D051150:Methionine Sulfoxide Reductases / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D009929:Organ Size; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D055815:Young Adult
chemical_list: C000593289:ASTN2 protein, human; D006023:Glycoproteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D051150:Methionine Sulfoxide Reductases; C524352:MSRB3 protein, human; C515549:MAST4 protein, human; D017346:Protein Serine-Threonine Kinases; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4