title: Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride.
abstract: Hepatoprotective properties of a new pyrimidine derivative - L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia. alex.vysh@mail.ru.
authors.forename: A B
authors.initials: AB
authors.lastname: Vyshtakalyuk
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.|Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Nazarov
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.|Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Zobov
authors.affiliation: Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: S R
authors.initials: SR
authors.lastname: Abdulkhakov
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Minnekhanova
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Semenov
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Galyametdinova
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.|Medical Unit of Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Cherepnev
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Reznik
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000737:chemistry*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D020011:Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D011743:Pyrimidines; C069705:xymedon; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001205:Ascorbic Acid
keywords: CCl 4; ascorbate; hepatoprotectors; pyrimidine derivatives; toxic liver damage