title: Mass Spectrometry Imaging in Cancer Research: Future Perspectives.
abstract: In the last decade mass spectrometry imaging has developed rapidly, in terms of multiple new instrumentation innovations, expansion of target molecules, and areas of application. Mass spectrometry imaging has already had a substantial impact in cancer research, uncovering biomolecular changes associated with disease progression, diagnosis, and prognosis. Many new approaches are incorporating the use of readily available formalin-fixed paraffin-embedded cancer tissues from pathology centers, including tissue blocks, biopsy specimens, and tumor microarrays. It is also increasingly used in drug formulation development as an inexpensive method to determine the distributions of drugs and their metabolites. In this chapter, we offer a perspective in the current and future methodological developments and how these may open up new vistas for cancer research.
authors.affiliation: Fondazione Pisana per la Scienza ONLUS, Pisa, Italy; Leiden University Medical Center, Leiden, The Netherlands. Electronic address: l.a.mcdonnell@oulook.com.
authors.forename: L A
authors.initials: LA
authors.lastname: McDonnell
authors.affiliation: Medical University of South Carolina, Charleston, SC, United States.
authors.forename: P M
authors.initials: PM
authors.lastname: Angel
authors.affiliation: Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Lou
authors.affiliation: Medical University of South Carolina, Charleston, SC, United States.
authors.forename: R R
authors.initials: RR
authors.lastname: Drake
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D035843:Biomedical Research; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarker; Cancer research; Mass spectrometry imaging; Perspectives