title: Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats.
abstract: The purpose of this research was to investigate the effects of vitamin D administration on cognitive function, nuclear factor-κB (NF-κB), brain-derived neurotrophic factor (BDNF) concentration in the hippocampus and blood-brain barrier (BBB) permeability in high-fat diet (HFD)-induced obese rats.
  
  
  
  Male Wistar rats were fed either a control diet or HFD for 16 weeks (n=20); then, each group was randomized into two subgroups supplemented orally with 500 IU kg-1vitamin D for 5 weeks. A Morris water maze (MWM) test was performed at the 21st week to examine cognitive function. BBB permeability was characterized by Evans blue dye in the hippocampus. BDNF and NF-κB concentrations in the hippocampus and serum vitamin D concentrations were also measured.
  
  
  
  HFD led to a significant delay in escape latency time and reduced time of MWM probe test because of increased NF-κB and decreased BDNF concentrations in the hippocampus. Vitamin D supplementation in the HFD group significantly reduced body weight, NF-κB concentrations, BBB permeability and increased BDNF concentrations in the hippocampus.
  
  
  
  Vitamin D reversed HFD-induced cognitive impairments by reduction of the NF-κB and elevation of BDNF concentrations and modulation of the BBB permeability in rats' hippocampus.
authors.affiliation: Nutrition Research Center, Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: G
authors.initials: G
authors.lastname: Hajiluian
authors.affiliation: Nutrition Research Center, Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: G
authors.initials: G
authors.lastname: Nameni
authors.affiliation: Department of Physiology, School of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: P
authors.initials: P
authors.lastname: Shahabi
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Mesgari-Abbasi
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Sadigh-Eteghad
authors.affiliation: Nutrition Research Center, Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: M A
authors.initials: MA
authors.lastname: Farhangi
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003071:Cognition / Q000187:drug effects*; D059305:Diet, High-Fat; D004734:Energy Metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D014807:Vitamin D / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D018836:Inflammation Mediators; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D014815:Vitamins; D014807:Vitamin D