title: Examination of the early wound healing process under different wound dressing conditions.
abstract: OBJECTIVE
  Various types of wound-healing dressings have been used to assist in the healing of surgical wounds. We analyzed the wound-healing process in an animal model using different existing wound dressings.
  
  
  METHODS
  Full-thickness defects were created using a biopsy punch on the backs of 7-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid [PGA]) or TERUDERMIS (collagen sponge [CS]) affixed using a rat jacket. The wound area, neo-epithelium length, and α-smooth muscle actin (α-SMA) expression were evaluated and compared among the control, PGA, and CS groups.
  
  
  RESULTS
  The wound areas in the control group on days 4 and 7 were significantly smaller than those in the PGA and CS groups. The expression of α-SMA in granulation tissue peaked on day 4 for all groups. The expression of α-SMA in the control group on days 4 and 7 after injury was greater than in the PGA and CS groups. However, there was no significant difference in the expression of α-SMA between the PGA and CS groups.
  
  
  CONCLUSIONS
  In this study, PGA and CS suppressed wound contracture and reduced expression of α-SMA in wound areas. However, PGA and CS did not affect the neo-epithelium length at the wound site.
authors.affiliation: Field of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan; Field of Dental Anesthesiology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan. Electronic address: S2000@dent.kagoshima-u.ac.jp.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kibe
authors.affiliation: Field of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Koga
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ryukyu University Hospital, University of the Ryukyus, Nishihara, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Nishihara
authors.affiliation: Field of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Fuchigami
authors.affiliation: Field of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yoshimura
authors.affiliation: Polymeric Biomaterials Group, Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, Tsukuba, Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Taguchi
authors.affiliation: Field of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D001415:Back / Q000601:surgery*; D001458:Bandages; D015415:Biomarkers / Q000378:metabolism; D003094:Collagen; D005260:Female; D011100:Polyglycolic Acid; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000502:physiology*
chemical_list: D000199:Actins; D015415:Biomarkers; D011100:Polyglycolic Acid; D003094:Collagen