title: Evaluation of arterial stiffness in nondiabetic chronic kidney disease patients.
abstract: Chronic kidney disease (CKD) is a growing problem worldwide. Clinical and epidemiologic studies have shown that structural and functional changes that occur in major arteries are a major contributing factor to the high mortality in uremic patients. Recent studies have shown a stepwise increase of the carotid-femoral pulse wave velocity (cfPWV) from CKD Stage 1 to Stage 5. We evaluated the cfPWV and augmentation index (AIx), as indirect markers of arterial stiffness in patients with nondiabetic CKD and compared the values with normal population; we also evaluated the relationship between various stages of CKD and arterial stiffness markers. This cross-sectional study was carried out in the Department of Nephrology for a duration of two years from January 15, 2012, to January 14, 2014. Fifty patients with nondiabetic CKD were studied along with 50 healthy volunteers who did not have CKD, who served as controls. Assessment of arterial stiffness (blood pressure, PWV, heart rate, aortic augmentation pressure, and AIx) was performed using the PeriScope device. PWV positively correlated with systolic and diastolic blood pressure, mean aortic arterial pressure, serum creatinine, and serum uric acid and negatively correlated with estimated glomerular filtration rate. Arterial stiffness increased as CKD stage increased and was higher in nondiabetic CKD group than in the general population. Arterial stiffness progressed gradually from CKD Stage 2 to 5, and then abruptly, in dialysis patients. Measures to decrease the arterial stiffness and its influence on decreasing cardiovascular events need further evaluation.
authors.affiliation: Department of Nephrology, Narayana Medical College and Hospital, Nellore, India.
authors.forename: Bodanapu
authors.initials: B
authors.lastname: Mastanvalli
authors.affiliation: Department of Nephrology, Narayana Medical College and Hospital, Nellore, India.
authors.forename: Kolla Praveen
authors.initials: KP
authors.lastname: Kumar
authors.affiliation: Department of Nephrology, Narayana Medical College and Hospital, Nellore, India.
authors.forename: Desai
authors.initials: D
authors.lastname: Madhav
authors.affiliation: Department of Nephrology, Narayana Medical College and Hospital, Nellore, India.
authors.forename: P L
authors.initials: PL
authors.lastname: Venkata Pakki Reddy
authors.affiliation: Advanced Research Center, Narayana Medical College and Hospital, Nellore, India.
authors.forename: Shaik Mahaboob
authors.initials: SM
authors.lastname: Vali
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D063177:Pulse Wave Analysis; D006435:Renal Dialysis / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D012307:Risk Factors; D059289:Vascular Stiffness; D055815:Young Adult