title: [Infective endocarditis: Clinical features and prognosis between 2004 and 2014 in a non-teaching hospital].
abstract: OBJECTIVE
  Despite diagnostic and therapeutic advances, infective endocarditis (IE) remains a severe disease. The aim of the study was to describe clinical features and prognosis of patients with IE in a non-teaching hospital and compare them with current data and a similar study conducted 10 years earlier in the same center.
  
  
  METHODS
  We performed a single institution retrospective study including all patients with Duke-Li definite IE between 2004 and 2014.
  
  
  RESULTS
  Ninety-four patients were included. Results are consistent with current French and international data, including in-hospital death rate of 16%. In accordance with literature, we report on an increase in Staphylococcus and health care-associated IE and endocarditis on pacemaker leads, but without significant difference compared to our previous study. In univariate analyses, renal failure, age over 77 years and Staphylococcus aureus IE were associated with in-hospital mortality. In multivariate analyses, predictors of in-hospital death were renal failure and lack of surgery. There was a non-significant trend of excess mortality in Staphylococcus endocarditis and in patients with heart failure.
  
  
  CONCLUSIONS
  IE remains a severe disease and S. aureus is more often involved. IE seems to be safely managed in a peripheral hospital provided that there is a partnership with a reference hospital.
authors.affiliation: Service de cardiologie, hôpital Sainte-Anne, BCRM, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: leocapilla@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Capilla
authors.affiliation: Service de cardiologie, hôpital Sainte-Anne, BCRM, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: raphael.poyet@yahoo.fr.
authors.forename: R
authors.initials: R
authors.lastname: Poyet
authors.affiliation: Service de cardiologie, hôpital Sainte-Anne, BCRM, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: avtortat@hotmail.fr.
authors.forename: A-V
authors.initials: AV
authors.lastname: Tortat
authors.affiliation: Service épidémiologique et recherche clinique, centre d'épidémiologie et de santé publique des armées (CESPA), GSBdD de Marseille Aubagne, 111, avenue de la Corse, BP 40026, 13568 Marseille cedex 02, France. Electronic address: joffrey.marchi@intradef.gouv.fr.
authors.forename: J
authors.initials: J
authors.lastname: Marchi
authors.affiliation: Centre d'expertise médicale du personnel navigant, hôpital Sainte-Anne, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: fxbrocq@hotmail.com.
authors.forename: F-X
authors.initials: FX
authors.lastname: Brocq
authors.affiliation: Service de cardiologie, hôpital Sainte-Anne, BCRM, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: fredogam@hotmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Pons
authors.affiliation: Service de cardiologie, hôpital Sainte-Anne, BCRM, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: sebastien.kerebel@wanadoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Kerebel
authors.affiliation: Service de cardiologie, hôpital Sainte-Anne, BCRM, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: christophejego@aol.com.
authors.forename: C
authors.initials: C
authors.lastname: Jego
authors.affiliation: Service épidémiologique et recherche clinique, centre d'épidémiologie et de santé publique des armées (CESPA), GSBdD de Marseille Aubagne, 111, avenue de la Corse, BP 40026, 13568 Marseille cedex 02, France. Electronic address: aurelie.mayet@sante.defense.gouv.fr.
authors.forename: A
authors.initials: A
authors.lastname: Mayet
authors.affiliation: Service de cardiologie, hôpital Sainte-Anne, BCRM, boulevard Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: gilles.cellarier@orange.fr.
authors.forename: G R
authors.initials: GR
authors.lastname: Cellarier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004452:Echocardiography / Q000379:methods; D017548:Echocardiography, Transesophageal / Q000379:methods; D004696:Endocarditis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D005260:Female; D006769:Hospitals, General; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D013211:Staphylococcus aureus / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Endocardite infectieuse; Endocardite infectieuse liée aux soins; Facteurs pronostiques; Health care-associated infective endocarditis; Infective endocarditis; Partenariat; Partnership practice; Prognostic factors; Staphylococcus