title: Isolation, characterization and antimicrobial activities of polyacetylene glycosides from Coreopsis tinctoria Nutt.
abstract: Polyacetylene glycosides, (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-β-D-glucopyranoside (trivially named coreoside E) and (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-β-L-arabinopyranosyl-(1 → 2)-β-D-glucopyranoside (trivially named coreoside F), were isolated from buds of Coreopsis tinctoria Nutt., together with one known compound, coreoside B. Their chemical structures were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivities. Coreoside E exhibited high levels of antimicrobial activity against Staphylococcus aureus and Bacillus anthracis with minimum inhibitory concentrations of 27 ± 0.27 and 18 ± 0.40 μM, respectively, whereas coreoside F and coreoside B showed weak antimicrobial activity against S. aureus and B. anthracis.
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Guo
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Ao
authors.initials: A
authors.lastname: Wang
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China; College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Ding
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Yumeng
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Huang
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Jingguo
authors.initials: J
authors.lastname: Xu
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Tianxing
authors.initials: T
authors.lastname: Liu
authors.affiliation: College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi, People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yang
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China. Electronic address: xzhfood@njau.edu.cn.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects; D031945:Coreopsis / Q000737:chemistry*; D005960:Glucosides; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D005960:Glucosides; D006027:Glycosides; C000613170:coreoside E; C000614651:coreoside F; D053279:Polyynes
keywords: Antimicrobial activity; Asteraceae; Coreopsis tinctoria Nutt.; Coreoside B; Coreoside E; Coreoside F; Polyacetylene glycosides