title: Tacrolimus-associated Diffuse Gastrointestinal Ulcerations and Pathergy: A Case Report.
abstract: Tacrolimus is a common immunosuppressive modality with a range of therapeutic applications, including for rheumatologic disease, nephrotic syndrome, and inflammatory bowel disease. The medication also plays an integral role in organ transplantation. However, tacrolimus has a significant side effect profile, which commonly includes nephrotoxicity, neurotoxicity, infection risk, and anemia. We describe an unusual case of tacrolimus toxicity in a cardiac transplant patient, manifesting as diffuse gastrointestinal ulcerations and pathergy. Our goal was to further characterize the toxicity of tacrolimus to include this rare presentation.
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
authors.forename: D
authors.initials: D
authors.lastname: Pan
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
authors.forename: O
authors.initials: O
authors.lastname: Shaye
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: kobashigawaj@cshs.org.
authors.forename: J A
authors.initials: JA
authors.lastname: Kobashigawa
mesh_terms: D000368:Aged; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced*; D011183:Postoperative Complications / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus