title: Treatment of the axilla in patients with primary breast cancer and low burden axillary disease: Limitations of the evidence from randomised controlled trials.
abstract: Invasive breast cancer is the second most common cancer worldwide. It is known to metastasise to the regional axillary lymph nodes but there has been debate over what is the best way to stage and treat the axilla in patients presenting with primary breast cancer. Multiple trials over the last two decades have led to a change in practice from routine axillary lymph node dissection to sentinel lymph node biopsy in patients who are clinically lymph node negative preoperatively. This has resulted in new questions regarding subsequent treatment of some patients. This review will critically appraise the evidence on axillary treatment in patients with low burden axillary disease and highlight limitations of relevant randomised controlled trials.
authors.affiliation: Faculty of Medicine and Health Sciences, University of Nottingham, Royal Derby Hospital, Derby, UK. Electronic address: John.robertson@nottingham.ac.uk.
authors.forename: J F R
authors.initials: JF
authors.lastname: Robertson
authors.affiliation: Faculty of Medicine and Health Sciences, University of Nottingham, Royal Derby Hospital, Derby, UK.
authors.forename: P J J
authors.initials: PJ
authors.lastname: Herrod
authors.affiliation: Department of Surgery, Peterborough City Hospital, Peterborough, UK.
authors.forename: J
authors.initials: J
authors.lastname: Matthew
authors.affiliation: The Institute of Cancer Research, London, UK.
authors.forename: L S
authors.initials: LS
authors.lastname: Kilburn
authors.affiliation: Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: C E
authors.initials: CE
authors.lastname: Coles
authors.affiliation: Frontier Science Scotland, Kincraig, UK.
authors.forename: I
authors.initials: I
authors.lastname: Bradbury
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D016032:Randomized Controlled Trials as Topic; D021701:Sentinel Lymph Node Biopsy
keywords: Axilla; Breast cancer; Surgery