title: Mechanisms on spasmolytic and anti-inflammatory effects of a herbal medicinal product consisting of myrrh, chamomile flower, and coffee charcoal.
abstract: Inflammatory bowel disease or irritable bowel syndrome are chronic gastrointestinal disorders which are associated with a lifelong therapeutic need. The disease results in physical, psychological, and social problems with an impact on partnership, sexuality, education, and career. Thus, the number of patients and health care professionals relying on traditional and complementary medicines and especially phytotherapy for the treatment of these chronic conditions is increasing over recent years. One traditional herbal medicinal product consisting of chamomile flower, myrrh, and coffee charcoal has been widely used in clinical practice within this indication area. Long-term experience and an increasing understanding of the pharmacological mechanisms substantiate its application and clinical effectiveness. Mainly the spasmolytic and anti-inflammatory effects provide a rationale for its therapeutic application. In addition, synergistic effects between the herbal components contribute to the overall effect of this medication.
authors.affiliation: REPHA GmbH Biologische Arzneimittel, Langenhagen, Germany. Cica.Vissiennon@uni-leipzig.de.|Medical Faculty, Institute of Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany. Cica.Vissiennon@uni-leipzig.de.
authors.forename: Cica
authors.initials: C
authors.lastname: Vissiennon
authors.affiliation: REPHA GmbH Biologische Arzneimittel, Langenhagen, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Goos
authors.affiliation: Medical Faculty, Institute of Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Arnhold
authors.affiliation: Institute of Pharmacy, University of Leipzig, Leipzig, Germany.
authors.forename: Karen
authors.initials: K
authors.lastname: Nieber
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D020843:Chamomile; D002606:Charcoal / Q000627:therapeutic use*; D003069:Coffee; D029744:Commiphora; D035264:Flowers; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D010276:Parasympatholytics / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D003069:Coffee; D010276:Parasympatholytics; D010936:Plant Extracts; D002606:Charcoal
keywords: Chamomile flower; Coffee charcoal; Inflammatory bowel disease; Intestinal motility; Myrrh