title: Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD.
abstract: : We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10 min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-term management of patients with stable hypercapnic COPD.
  
  
  BACKGROUND
  NCT02363920.
authors.affiliation: Department of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
authors.forename: Lara
authors.initials: L
authors.lastname: Pisani
authors.affiliation: Sant'Orsola Malpighi Hospital, Bologna, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Fasano
authors.affiliation: Department of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Corcione
authors.affiliation: Department of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
authors.forename: Vittoria
authors.initials: V
authors.lastname: Comellini
authors.affiliation: Department of Public Health, Local Health Authority of Bologna, Bologna, Italy.
authors.forename: Muriel Assunta
authors.initials: MA
authors.lastname: Musti
authors.affiliation: Respiratory Department, Centro Hospitar de Tràs-os-Montes e Alto Douro, São Pedro de Vila Rea, Portugal.
authors.forename: Maria
authors.initials: M
authors.lastname: Brandao
authors.affiliation: Respiratory Medicine Unit, Department of Clinical and Experimental Sciences, Universita' degli Studi di Brescia, Brescia, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Bottone
authors.affiliation: Department of Anesthesia and Intensive Care, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Calderini
authors.affiliation: Department of Translational Medicine, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.|Department of Anesthesia and Intensive Care Medicine, Sant'Andrea Hospital, Vercelli, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Navalesi
authors.affiliation: Department of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Nava
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D063087:Noninvasive Ventilation; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000628:therapy*; D011659:Pulmonary Gas Exchange; D012129:Respiratory Function Tests; D016896:Treatment Outcome
keywords: COPD Pathology; Long Term Oxygen Therapy (LTOT); Non invasive ventilation; Respiratory Measurement