title: Is Diabetic Skeletal Fragility Associated with Microvascular Complications in Bone?
abstract: The objective of this literature review is to determine whether there are indications that microvascular complications occur in diabetic bone. Evidence definitively linking diabetic skeletal fragility with microvascular complications in bone remains elusive.
  
  
  
  Circumstantial evidence, some recent and some lost to time, suggests that atherosclerotic vascular diseases such as peripheral arterial disease cause poor blood perfusion of bone and subsequent hypoxia and contribute to low bone density and high cortical porosity, patterns similar to some recently observed in diabetic subjects. Evidence also exists to suggest that potentially anti-angiogenic conditions, such as impaired vascular endothelial growth factor (VEGF) signaling, predominate in diabetic bone. Microvascular complications may contribute, in part, to diabetic skeletal fragility but data supporting this interpretation are primarily circumstantial at this time. This review highlights gaps in our knowledge and hopefully spurs further discussions and research on this topic.
authors.affiliation: Department of Orthopaedics, University of Texas Health Science Center at San Antonio, Med 518C, 7703 Floyd Curl Dr., San Antonio, TX, 78229, USA. fajardor@uthscsa.edu.
authors.forename: Roberto Jose
authors.initials: RJ
authors.lastname: Fajardo
mesh_terms: D001853:Bone Marrow / Q000098:blood supply*; D001842:Bone and Bones / Q000098:blood supply* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D050723:Fractures, Bone / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D000073436:Microvascular Rarefaction / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Atherosclerosis; Cortical porosity; Fracture risk; Type 2 diabetes; Vascular disease