title: Long noncoding RNA as an indicator differentiating schizophrenia from major depressive disorder and generalized anxiety disorder in nonpsychiatric hospital.
abstract: OBJECTIVE
  Depression and anxiety are common symptoms for schizophrenia (SZ) in the early onset. This study aimed to determine whether long noncoding RNAs (lncRNAs) can be indicators for diagnosing SZ in nonpsychiatric hospitals.
  
  
  METHODS
  Three upregulated SZ lncRNAs, six downregulated major depressive disorder (MDD) lncRNAs and three upregulated generalized anxiety disorder (GAD) lncRNAs were cross-validated in 45 SZ patients, 48 MDD patients, 52 GAD patients and 40 controls by reverse transcription-PCR.
  
  
  RESULTS
  Three SZ lncRNAs were significantly downregulated in GAD patients. The expression of the six MDD lncRNAs showed an opposite trend in SZ patients, and the three GAD lncRNAs also showed significant differences between SZ and GAD patients.
  
  
  CONCLUSIONS
  The three upregulated SZ lncRNAs are not entirely replicated in MDD and GAD patients and could be potential indicators for distinguishing SZ from MDD and GAD in nonpsychiatric hospital.
authors.affiliation: Department of Health Care, Changzhou Maternity & Child Health Care Hospital Affiliated with Nanjing Medical University, Changzhou, People's Republic of China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Rehabilitation, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Niu
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Lingming
authors.initials: L
authors.lastname: Kong
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: He
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Kunhong
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Department of Neurology, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Shengdong
authors.initials: S
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Aifang
authors.initials: A
authors.lastname: Zhong
authors.affiliation: Department of Special Ward, The First People's Hospital of Changzhou, Changzhou, People's Republic of China.
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Gopath Diagnostic Laboratory Co. Ltd, No. 801, Changzhou, People's Republic of China.
authors.forename: Wanshuai
authors.initials: W
authors.lastname: Li
authors.affiliation: Gopath Diagnostic Laboratory Co. Ltd, No. 801, Changzhou, People's Republic of China.|Gopath Laboratories LLC, 1351 Barclay Blvd, Buffalo Grove, IL 60089, USA.
authors.forename: Jim
authors.initials: J
authors.lastname: Lu
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Liyi
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis*; D015415:Biomarkers / Q000378:metabolism*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000175:diagnosis*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000175:diagnosis*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D062085:RNA, Long Noncoding
keywords: biomarker; lncRNA; nonpsychiatric hospital; schizophrenia