title: Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects.
abstract: X-ray crystal structures of three Λ-[Ru(L)2dppz]2+complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2'-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5'-CG-3' step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2group, in contrast to symmetrical intercalation previously observed at 5'-TA-3' sites. This result suggests that canted intercalation is preferred at 5'-CG-3' sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5'-CG-3' step could give rise to a longer luminescence lifetime than canted intercalation.
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.|Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK.
authors.forename: James P
authors.initials: JP
authors.lastname: Hall
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.|Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK.
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Gurung
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Henle
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: Patrick
authors.initials: P
authors.lastname: Poidl
authors.affiliation: Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412-96, Gothenberg, Sweden.|Department of Chemistry - BMC, Uppsala University, Box 576, 751 23, Uppsala, Sweden.
authors.forename: Johanna
authors.initials: J
authors.lastname: Andersson
authors.affiliation: Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412-96, Gothenberg, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Lincoln
authors.affiliation: Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK.
authors.forename: Graeme
authors.initials: G
authors.lastname: Winter
authors.affiliation: Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sorensen
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Cardin
authors.affiliation: Department of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: John A
authors.initials: JA
authors.lastname: Brazier
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Cardin
mesh_terms: D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D049449:Luminescence; D009942:Organometallic Compounds / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D007364:Intercalating Agents; D009942:Organometallic Compounds; D010618:Phenanthrolines; D006147:Guanine; D012428:Ruthenium; D004247:DNA; C025205:1,10-phenanthroline
keywords: DNA; DNA structures; nucleic acids; structural biology