title: Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.
abstract: In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβand tau to neurodegeneration in Alzheimer's disease.
authors.affiliation: Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany; Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany.
authors.forename: Gérard N
authors.initials: GN
authors.lastname: Bischof
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE) Bonn Germany; Department of Psychiatry University Hospital Cologne Cologne Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE) Bonn Germany; Department of Psychiatry and Psychotherapy University Hospital Bonn Bonn Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Fliessbach
authors.affiliation: Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany; Department of Neurology University Hospital Cologne Cologne Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Dronse
authors.affiliation: Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Hammes
authors.affiliation: Institute of Radiochemistry and Experimental Molecular Imaging University of Cologne Cologne Germany; Institute of Neuroscience & Medicine (INM-5)Nuclear Chemistry Research Center Jülich Jülich Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Neumaier
authors.affiliation: Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany; Department of Neurology University Hospital Cologne Cologne Germany.
authors.forename: Oezguer
authors.initials: O
authors.lastname: Onur
authors.affiliation: Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany; Department of Neurology University Hospital Cologne Cologne Germany.
authors.forename: Gereon R
authors.initials: GR
authors.lastname: Fink
authors.affiliation: Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany; Department of Neurology University Hospital Cologne Cologne Germany.
authors.forename: Juraj
authors.initials: J
authors.lastname: Kukolja
authors.affiliation: Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany; German Center for Neurodegenerative Diseases (DZNE) Bonn Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
authors.affiliation: Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany; Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany; German Center for Neurodegenerative Diseases (DZNE) Bonn Germany; Department of Neurology University Hospital Cologne Cologne Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: van Eimeren