title: Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report.
abstract: Pathological response to preoperative chemotherapy was recently found to be correlated with improved survival and has been proposed as a new outcome end-point following resection of liver metastases from colorectal cancer (CRC). It was demonstrated that, particularly after therapy with bevacizumab, CRC liver metastases decreased in size and underwent distinct morphological changes on computed tomography (CT). However, morphological changes in response to treatment with regorafenib have not yet been reported. A 73-year-old male patient with synchronous multiple liver and lung metastases from colon cancer was treated with regorafenib as a fifth-line therapy. CT imaging revealed a decrease in the tumor size and distinct morphological changes, namely homogeneous attenuation and sharp tumor-liver interface. The patient continued to take regorafenib for 8 months. Thus, regorafenib appeared to be effective as a last-line chemotherapy. In particular, the unique morphological changes of the metastases on CT imaging of may represent a method for evaluating the effects of CRC cancer therapy.
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Matsuhashi
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Kato
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanahashi
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsui
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sasaki
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Imai
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tanaka
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Okumura
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamaguchi
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Futamura
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Osada
authors.affiliation: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501-1194, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshida
keywords: colorectal cancer liver metastases; morphological change; regorafenib