title: A bioorthogonal 'turn-on' fluorescent probe for tracking mitochondrial nitroxyl formation.
abstract: A bioreductant-resistant 'turn-on' chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Kyoung
authors.initials: K
authors.lastname: Sunwoo
authors.forename: Kondapa Naidu
authors.initials: KN
authors.lastname: Bobba
authors.forename: Ja-Yun
authors.initials: JY
authors.lastname: Lim
authors.forename: Taegun
authors.initials: T
authors.lastname: Park
authors.forename: Arup
authors.initials: A
authors.lastname: Podder
authors.forename: June Seok
authors.initials: JS
authors.lastname: Heo
authors.forename: Seung Gwan
authors.initials: SG
authors.lastname: Lee
authors.forename: Sankarprasad
authors.initials: S
authors.lastname: Bhuniya
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim