title: Usefulness of House Dust Mite Nasal Provocation Test in Asthma.
abstract: OBJECTIVE
  We previously reported that the skin prick test was sensitive and the serum specific immunoglobulin E test was specific for predicting positive airway responses to house dust mites (HDMs) in patients with asthma. Because the nose and bronchus are one airway, the nasal provocation test would be more specific for predicting the bronchial responses to HDM than the skin test.
  
  
  METHODS
  The allergy skin prick test and nasal and bronchial provocation tests using HDM (Dermatophagoides farinae) were performed in 41 young men (age, 19-28 years) who wanted military certification for asthma. The nasal responses to HDM was scored according to the severity of rhinorrhea, sneezing, and nose itching.
  
  
  RESULTS
  The prevalence of a positive skin prick test to HDM did not significantly differ between patients with (n=24) and without (n=17) an early airway reaction (EAR; 79.2% vs 70.6%, P=0.534). However, the prevalence of a positive nasal test was significantly higher in the airway responders than in the others (37.5% vs 0%, P=0.005). The concordance of a positive response to the nasal test (κ=0.332, P=0.004) but not to the skin prick test (κ=0.091, P=0.529) was significant with an EAR. The diagnostic sensitivity of the nasal test (37.5%) was lower than that of the skin prick test (79.2%), but the specificity was higher (100% vs 29.4%).
  
  
  CONCLUSIONS
  The skin prick test is more sensitive, whereas the nasal test is more specific and accurate, for predicting an EAR to HDM in patients with asthma.
authors.affiliation: Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea. ischoi@chonnam.ac.kr.
authors.forename: Inseon S
authors.initials: IS
authors.lastname: Choi
authors.affiliation: Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea.
authors.forename: Soo Jeong
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea.
authors.forename: Joo Min
authors.initials: JM
authors.lastname: Won
authors.affiliation: Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea.
authors.forename: Myeong Soo
authors.initials: MS
authors.lastname: Park
keywords: Asthma; Dermatophagoides farinae; nasal provocation test