title: Comparison of serum lipid profile in Type-2 Diabetics with and without retinopathy in Pakistani population.
abstract: OBJECTIVE
  To compare serum cholesterol, TG, HDL-C and LDL-C concentrations between type-2 Diabetes mellitus (DM) patients with retinopathy and without retinopathy and to study association between various modifiable risk factors of Diabetic retinopathy (DR).
  
  
  METHODS
  The study included 300 patients with type 2 DM; 140 of them were without DR (Group-I) and 160 were with DR (Group-II). Serum total cholesterol, LDL-C, HDL-C, and TG levels were determined. SPSS 17.0 for windows was used for statistical analysis.
  
  
  RESULTS
  Overall, mean age of study population was 48.86 ± 5.62 years. Subjects with DR were older (P< 0.018), had higher fasting plasma glucose (P< 0.01) and higher HbA1c (P<0.01) concentrations compared with those without DR. Analysis of serum cholesterol, LDL-C, HDL-C and TG among subgroups of patients with no DR, with NPDR and PDR showed statistically significant difference (p <0.01). There was strong positive correlation of severity of DR with BSF, HbA1c, serum LDL-C, total cholesterol and TG.
  
  
  CONCLUSIONS
  The serum cholesterol, TG, HDL-C and LDL-C concentrations were found to be significantly deranged in patients with DR as compared to those without DR.
authors.affiliation: Dr. Zulfiqar Ali Amin, FCPS (Med), FCPS (Medical Oncology). Department of Medicine, PNS Shifa Hospital, Karachi, Pakistan.
authors.forename: Zulfiqar Ali
authors.initials: ZA
authors.lastname: Amin
authors.affiliation: Dr. Qamar Ul Islam, FCPS (Ophthalmology), FCPS (VRO). Department of Ophthalmology, PNS Shifa Hospital, Karachi, Pakistan.
authors.forename: Qamar Ul
authors.initials: QU
authors.lastname: Islam
authors.affiliation: Dr. Mohammad Asim Mehboob, MBBS. Department of Ophthalmology, PNS Shifa Hospital, Karachi, Pakistan.
authors.forename: Mohammad Asim
authors.initials: MA
authors.lastname: Mehboob
keywords: Diabetes mellitus; Diabetic retinopathy; Dyslipidaemia; Lipid profile