title: DNA sensing and immune responses in cancer therapy.
abstract: The identification of critical DNA sensors and their pathways has led to revealing the central role of DNA sensing in immune system. It has been initially demonstrated that DNA sensing and immune responses have high impacts on the development and prevention of infection and inflammatory. In addition to toll-like receptor pathways, there is now also emerging evidence that cytosolic enzyme cyclic GMP-AMP synthase (cGAS) is essential for the recognition of not only pathogen-derived DNA but also tumor DNA for innate sensing. The strategies through activating DNA sensing pathways toward enhancing antitumor immunity have shown promise and are further tested in clinical studies. Here, we highlight recent progresses in understanding mechanisms activated by DNA sensing mediated immune responses in cancer therapy.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Qiao
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
authors.forename: Haidong
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address: Yang-Xin.Fu@UTSouthwestern.edu.
authors.forename: Yang-Xin
authors.initials: YX
authors.lastname: Fu
mesh_terms: D000818:Animals; D004273:DNA, Neoplasm / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D009713:Nucleotidyltransferases / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*; D000099235:Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase
chemical_list: D004273:DNA, Neoplasm; D009713:Nucleotidyltransferases; D051193:Toll-Like Receptors; C578390:cGAS protein, human; D000099235:Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase