title: Activity-dependent development of visual receptive fields.
abstract: It is widely appreciated that neuronal activity contributes to the development of brain representations of the external world. In the visual system, in particular, it is well known that activity cooperates with molecular cues to establish the topographic organization of visual maps on a macroscopic scale [1,2] (Huberman et al., 2008; Cang and Feldheim, 2013), mapping axons in a retinotopic and eye-specific manner. In recent years, significant progress has been made in elucidating the role of activity in driving the finer-scale circuit refinement that shapes the receptive fields of individual cells. In this review, we focus on these recent breakthroughs-primarily in mice, but also in other mammals where noted.
authors.affiliation: Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Thompson
authors.affiliation: Department of Neuroscience, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gribizis
authors.affiliation: Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: chinfei.chen@childrens.harvard.edu.
authors.forename: Chinfei
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Neuroscience, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: michael.crair@yale.edu.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Crair
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D003463:Cues; D012160:Retina / Q000502:physiology; D014794:Visual Fields / Q000235:genetics / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology