title: Photoactive meso-tetra(4-pyridyl)porphyrin-tetrakis-[chloro(2,2'bipyridine)platinum(ii) derivatives recognize and cleave DNA upon irradiation.
abstract: In this work, we evaluate the interaction of the peripheral Pt(bpy)Cl+substituted porphyrins, H2PtPor and ZnPtPor with DNA using UV-vis, emission fluorescence, CD spectroscopy, and DNA melting properties altered by the Pt(ii)-porphyrinoid compounds. Additionally, we observe the ability of these porphyrin derivatives to generate1O2and to efficiently photocleave plasmid DNA upon visible light irradiation based on a mixed (oxidative/hydrolytic) mechanism.
authors.affiliation: Centro de Biologia Molecular Estrutural, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil. Hernan.terenzi@ufsc.br.
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Oliveira
authors.affiliation: Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil.
authors.forename: Bernardo A
authors.initials: BA
authors.lastname: Iglesias
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil.
authors.forename: Bruna L
authors.initials: BL
authors.lastname: Auras
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil.
authors.forename: Ademir
authors.initials: A
authors.lastname: Neves
authors.affiliation: Centro de Biologia Molecular Estrutural, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil. Hernan.terenzi@ufsc.br.
authors.forename: Hernán
authors.initials: H
authors.lastname: Terenzi