title: Sinusoidal Obstruction Syndrome During Maintenance Therapy for Acute Lymphoblastic Leukemia With 6-Mercaptopurine and Methotrexate: A Pediatric Case Report.
abstract: We report a case of a child with pre-B cell acute lymphoblastic leukemia undergoing maintenance chemotherapy with 6-mercaptopurine and methotrexate (MTX) who developed sinusoidal obstruction syndrome after being treated with ciprofloxacin for BK viremia. This case represents a rare complication of maintenance therapy with MTX and 6-mercaptopurine, and suggests a drug interaction between ciprofloxacin and MTX.
authors.affiliation: Departments of *Pediatrics †Hematology and Oncology, Yale New Haven Hospital, New Haven, CT.
authors.forename: Kevin O
authors.initials: KO
authors.lastname: McNerney
authors.forename: Juan C
authors.initials: JC
authors.lastname: Vasquez
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kent
authors.forename: Joseph M
authors.initials: JM
authors.lastname: McNamara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D015415:Biomarkers; D001706:Biopsy; D002648:Child; D004347:Drug Interactions; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D006801:Humans; D060046:Maintenance Chemotherapy / Q000009:adverse effects; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D064847:Multimodal Imaging / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D015415:Biomarkers; D015122:Mercaptopurine; D008727:Methotrexate