title: Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease.
abstract: BACKGROUND
  We investigated the potential role of several pattern-recognition receptors (PRRs; CD11b, CD11c, CD32, CD206, CD209, and dectin-1) in adult-onset Still's disease (AOSD).
  
  
  METHODS
  The study included 13 untreated AOSD patients, 19 rheumatoid arthritis (RA) patients (as a disease control), and 19 healthy controls (HCs). The PRRs were quantified in peripheral blood using flow cytometry. The serum levels of interleukin-17 (IL-17), IL-18, and IL-23 were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Significantly higher mean frequencies of cells presenting CD11b and CD32 from whole blood were observed in patients with AOSD than in patients with RA or HC. The levels of IL-17, IL-18, and IL-23 were elevated in AOSD patients compared to HCs. CD11b frequencies from whole cells correlated with systemic scores, lactate dehydrogenase (LDH) levels, aspartate transaminase levels, interleukin-23 (IL-23) levels, and IL-18. Frequencies of CD209 from granulocytes were significantly correlated with systemic scores, and the erythrocyte sedimentation rate and levels of C-reactive protein, ferritin, LDH, IL-23, and interleukin-18 (IL-18).
  
  
  CONCLUSIONS
  Elevated frequencies of circulating CD11b-positive cells and positive correlations with disease activity markers suggest that circulating CD11b-positive cells contribute to the pathogenesis of AOSD.
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. nakhada@naver.com.
authors.forename: Hyoun-Ah
authors.initials: HA
authors.lastname: Kim
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. blueppang@aumc.ac.kr.
authors.forename: Bunsoon
authors.initials: B
authors.lastname: Choi
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. chsuh@ajou.ac.kr.
authors.forename: Chang-Hee
authors.initials: CH
authors.lastname: Suh
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. clearmifa@hanmail.net.
authors.forename: Mi Hwa
authors.initials: MH
authors.lastname: Han
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. serinne20@hanmail.net.
authors.forename: Ju-Yang
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Department of Biomedical Science, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. Sayeed@ajou.ac.kr.
authors.forename: Hasan M
authors.initials: HM
authors.lastname: Sayeed
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. Kyw1016@hanmail.net.
authors.forename: Ye Won
authors.initials: YW
authors.lastname: Kim
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. sohnsh@ajou.ac.kr.|Department of Biomedical Science, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. sohnsh@ajou.ac.kr.
authors.forename: Seonghyang
authors.initials: S
authors.lastname: Sohn
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood; D015415:Biomarkers / Q000378:metabolism; D039481:CD11b Antigen / Q000378:metabolism*; D016022:Case-Control Studies; D002452:Cell Count; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007378:Interleukins / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017452:Receptors, IgG / Q000378:metabolism*; D016706:Still's Disease, Adult-Onset / Q000097:blood*
chemical_list: D015415:Biomarkers; D039481:CD11b Antigen; D007378:Interleukins; D017452:Receptors, IgG
keywords: CD11b; CD32; adult-onset still’s disease; disease activity; pattern recognition receptor