title: Rabies virus vaccine as an immune adjuvant against cancers and glioblastoma: new studies may resurrect a neglected potential.
abstract: To review the literature about the use of Rabies Virus-Vaccine (RV-V) as an anticancer immunotherapeutic modality in the light of recent findings. The literature search in relevant databases with the following key words: Rabies virus, cancer, remission. Remissions occured following RV-V injections in patients with cervical cancer and melanoma. Pilot clinical studies showed that RV-V injections enhanced survival in glioblastoma patients, which is supported by findings in GL261 mouse glioma model. If public health studies demonstrate protective role of RV-V against certain types of cancers, it can be benefitted as a novel immune adjuvant in clinic.
authors.affiliation: Neuro-Academy Research Group, Sisli, Istanbul, Turkey. maltinoz@gmail.com.
authors.forename: M A
authors.identifier: http://orcid.org/0000-0001-7804-4087
authors.initials: MA
authors.lastname: Altinoz
authors.affiliation: Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands.|Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: S
authors.initials: S
authors.lastname: Guloksuz
authors.affiliation: Department of Neurosurgery, Memorial Hospital, Sisli, Istanbul, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Elmaci
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D005909:Glioblastoma / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D011818:Rabies / Q000150:complications* / Q000821:virology; D011819:Rabies Vaccines / Q000627:therapeutic use*; D011820:Rabies virus / Q000472:pathogenicity*
chemical_list: D000276:Adjuvants, Immunologic; D011819:Rabies Vaccines
keywords: Cancer; Immunotherapy; Rabies virus; Spontaneous remission