title: Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome.
abstract: We used the 28-joint Disease Activity Score (DAS28) and the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) articular domain to assess the effect of rituximab (RTX) and abatacept (ABA) on articular involvement in primary Sjögren syndrome (pSS).
  
  
  
  Patients with pSS treated with RTX (n = 18) or ABA (n = 13) and having a DAS28 erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP) level ≥ 3.2 at baseline were selected. Generalized estimating equations were used to analyze the DAS28 and ESSDAI articular domain over time.
  
  
  
  In the RTX group, DAS28-ESR/CRP decreased significantly up to 48 weeks. In the ABA group, DAS28-ESR/CRP decreased significantly up to 24 weeks. DAS28 correlated significantly with ESSDAI articular domain.
  
  
  
  DAS28 is useful to evaluate the effect of biologicals on articular involvement in patients with pSS.
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
authors.forename: Rada V
authors.initials: RV
authors.lastname: Moerman
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Arends
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
authors.forename: Petra M
authors.initials: PM
authors.lastname: Meiners
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
authors.forename: Arjan
authors.initials: A
authors.lastname: Vissink
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
authors.forename: Frederik K L
authors.initials: FK
authors.lastname: Spijkervet
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
authors.forename: Frans G M
authors.initials: FG
authors.lastname: Kroese
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Brouwer
authors.affiliation: From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands. h.bootsma@umcg.nl.|R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen. h.bootsma@umcg.nl.
authors.forename: Hendrika
authors.initials: H
authors.lastname: Bootsma
mesh_terms: D000069594:Abatacept / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069283:Rituximab / Q000627:therapeutic use*; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D000069283:Rituximab; D000069594:Abatacept
keywords: 28-JOINT DISEASE ACTIVITY SCORE; ARTICULAR INVOLVEMENT; BIOLOGICALS; ESSDAI ARTICULAR DOMAIN; PRIMARY SJÖGREN SYNDROME