title: 30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.
abstract: NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.
authors.affiliation: Department of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Molecular Development of the Immune System Section and NIAID Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: lenardo@nih.gov.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lenardo
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: David
authors.initials: D
authors.lastname: Baltimore
mesh_terms: D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D009154:Mutation; D016328:NF-kappa B / Q000737:chemistry / Q000235:genetics / Q000266:history* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B
keywords: I-κB; NF-κB; Rel; gene regulation; genetic disease; genomics; human gene; immunity; lymphocyte; transactivator