title: Prevalence of vertebral fracture and densitometric osteoporosis in Spanish adult men: The Camargo Cohort Study.
abstract: The aim of this study was to assess the prevalence of densitometric osteoporosis and vertebral fractures in Spanish men aged ≥50 years, and to study how the relationship between them may change depending on how osteoporosis is diagnosed. A community-based population of 1003 men aged ≥50 years was studied. Bone mineral density (BMD) was measured by DXA at the lumbar spine, femoral neck and total hip. Vertebral fractures were assessed by lateral thoracic and lumbar spine radiographs. The prevalence of osteoporosis was estimated with both the World Health Organization (WHO) (T-score of <-2.5 at the femoral neck, calculated using the young white female normal reference database) and the National Osteoporosis Foundation (NOF) criteria (T-score of <-2.5 at the femoral neck, total hip or lumbar spine, calculated using the young white male normal reference database). The prevalence of osteoporosis using the WHO criterion was 1.1% and using the NOF criterion was 13%, while that of vertebral fractures was 21.3%. The area under the curve (AUC) for the relationship between BMD and vertebral fracture prevalence was 0.64. The odds ratio for osteoporosis using the WHO definition was 2.57 (p = 0.13), and 1.78 (p = 0.007) using the NOF definition. Vertebral fracture prevalence rose with age. The prevalence of osteoporosis increased only moderately in men aged >70 years with the WHO criterion, and showed no change using the NOF definition. The prevalence of osteoporosis in Spanish men using the WHO definition is too small to have any meaningful clinical use. Although the figure is higher using the NOF definition, it would seem that population-based studies of BMD in men are of questionable value.
authors.affiliation: Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Avda. Valdecilla s/n. 39008, Santander, Spain. miromj@humv.es.|Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Instituto de Salud Carlos III, Santander, Spain. miromj@humv.es.
authors.forename: José M
authors.identifier: http://orcid.org/0000-0002-7765-0891
authors.initials: JM
authors.lastname: Olmos
authors.affiliation: Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Avda. Valdecilla s/n. 39008, Santander, Spain.|Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Instituto de Salud Carlos III, Santander, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Hernández
authors.affiliation: Clinical Biochemistry Service, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain.
authors.forename: Josefina
authors.initials: J
authors.lastname: Martínez
authors.affiliation: Centro de Salud de Camargo, Universidad de Cantabria, Santander, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Pariente
authors.affiliation: Centro de Salud de Camargo, Universidad de Cantabria, Santander, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Castillo
authors.affiliation: GREMPAL Research Group, Idiap Jordi Gol Primary Care Research Institute, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, RETICEF, Instituto de Salud Carlos III, Barcelona, Spain.|Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Prieto-Alhambra
authors.affiliation: Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Avda. Valdecilla s/n. 39008, Santander, Spain.|Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Instituto de Salud Carlos III, Santander, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: González-Macías
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015519:Bone Density; D015331:Cohort Studies; D003720:Densitometry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012372:ROC Curve; D012307:Risk Factors; D013030:Spain; D016103:Spinal Fractures / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000503:physiopathology; D013997:Time Factors; D044465:White People
keywords: Bone mineral density; Men; Osteoporosis; Vertebral fracture