title: New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb.
abstract: A new phenylpropanoid glycoside (1), and two new coumarin glycosides (2,3), together with two known compounds (4,5), have been isolated from the stems ofHydrangea paniculataSieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound1(50 μM) exhibited significant hepatoprotective activity againstN-acetyl-p-aminophenol (APAP)-induced HepG2 cell damagein vitroassays.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. majie@imm.ac.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. lichuangjun@imm.ac.cn.
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. yjzh@imm.ac.cn.
authors.forename: Jing-Zhi
authors.initials: JZ
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. sunhua@imm.ac.cn.
authors.forename: Hua
authors.initials: H
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. zhangdm@imm.ac.cn.
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D000082:Acetaminophen / Q000037:antagonists & inhibitors / Q000633:toxicity; D058633:Antipyretics / Q000037:antagonists & inhibitors / Q000633:toxicity; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D031966:Hydrangea / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D020005:Propanols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020011:Protective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D058633:Antipyretics; D003374:Coumarins; D006027:Glycosides; D020005:Propanols; D020011:Protective Agents; D000082:Acetaminophen
keywords: Hydrangea paniculata; coumarin glycoside; hepatoprotective activity; phenylpropanoid glycoside