title: Oral mucous membrane pemphigoid and pemphigus vulgaris-a retrospective two-center cohort study.
abstract: OBJECTIVE
  Few studies have compared oral mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Descriptive analysis of oral features, extent of extra-oral involvement, and management outcomes were performed.
  
  
  METHODS
  Patients with PV and MMP, the latter with exclusive oral involvement at first presentation, were included.
  
  
  RESULTS
  There were 26 MMP (46%) and 31 PV (54%) patients. Desquamative gingivitis was evident in 84% of MMP cases compared to 28% of PV cases (P < 0.05). Non-gingival lesions were noted in 6% of MMP cases compared to 55% of PV cases (P < 0.01). Management of MMP consisted of only topical corticosteroids in 88% of cases while 12% of cases required concomitant systemic therapy. All PV cases (100%) required systemic therapy. No patients with MMP developed scarring or ocular lesions, and one patient (4%) developed cutaneous lesions. Five PV cases (16%) had oral cavity involvement only with three (60%) developing pharyngeal involvement and two (40%) developing cutaneous lesions on follow-up.
  
  
  CONCLUSIONS
  Oral MMP presents primarily as desquamative gingivitis, infrequently involving extragingival sites, and is highly amenable to topical therapy, while PV is a systemic mucocutaneous disease with extensive non-gingival oral lesions that almost always requires systemic therapy.
authors.affiliation: Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.|Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: A S
authors.identifier: http://orcid.org/0000-0001-5286-4562
authors.initials: AS
authors.lastname: Sultan
authors.affiliation: Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.|Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Villa
authors.affiliation: Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Saavedra
authors.affiliation: Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.|Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Treister
authors.affiliation: Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.|Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: S-B
authors.initials: SB
authors.lastname: Woo
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D010390:Pemphigoid, Benign Mucous Membrane / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D010392:Pemphigus / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents
keywords: desquamative gingivitis; gingival involvement; oral manifestations; oral mucous membrane pemphigoid; oral pemphigus vulgaris