title: Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention - a report from SCAAR.
abstract: BACKGROUND
  The prognostic role of hypertension on long-term survival after percutaneous coronary intervention (PCI) is limited and inconsistent. We hypothesize that hypertension increases long-term mortality after PCI.
  
  
  METHODS
  We analyzed data from SCAAR (Swedish Coronary Angiography and Angioplasty Registry) for all consecutive patients admitted coronary care units in Sweden between January 1995 and May 2013 and who underwent PCI due to ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI)/unstable angina (UA) or stable angina pectoris. We used Cox proportional-hazards regression for statistical modelling on complete-case data as well as on imputed data sets. We used interaction test to evaluate possible effect-modulation of hypertension on risk estimates in several pre-specified subgroups: age categories, gender, diabetes, smoking and indication for PCI (STEMI, NSTEMI/UA and stable angina).
  
  
  RESULTS
  During the study period, 175,892 consecutive patients underwent coronary angiography due to STEMI, NSTEMI/UA or stable angina. 78,100 (44%) of these had hypertension. Median follow-up was 5.5 years. After adjustment for differences in patient's characteristics, hypertension was associated with increased risk for mortality (HR 1.12, 95% CI 1.09-1.15, p < .001). In subgroup analysis, risk was highest in patients less than 65 years, in smokers and in patients with STEMI. The risk was lowest in patients with stable angina (p < .001 for interaction test).
  
  
  CONCLUSIONS
  Hypertension is associated with higher mortality in patients with STEMI, NSTEMI/UA or stable angina who are treated with PCI.
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Ott
authors.initials: O
authors.lastname: Saluveer
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Redfors
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Oskar
authors.initials: O
authors.lastname: Angerås
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Christian
authors.initials: C
authors.lastname: Dworeck
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Inger
authors.initials: I
authors.lastname: Haraldsson
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Charlotta
authors.initials: C
authors.lastname: Ljungman
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Petur
authors.initials: P
authors.lastname: Petursson
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Jacob
authors.initials: J
authors.lastname: Odenstedt
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Dan
authors.initials: D
authors.lastname: Ioanes
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Lundgren
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Völz
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Truls
authors.initials: T
authors.lastname: Råmunddal
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Bert
authors.initials: B
authors.lastname: Andersson
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Elmir
authors.initials: E
authors.lastname: Omerovic
authors.affiliation: a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
authors.forename: Niklas
authors.initials: N
authors.lastname: Bergh
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D000367:Age Factors; D000368:Aged; D000787:Angina Pectoris / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000503:physiopathology; D013548:Sweden; D016896:Treatment Outcome
keywords: Acute coronary syndrome; PCI; Swedish Coronary Angiography and Angioplasty Registry; hypertension; survival