title: ERRATUM.
abstract: Ovarian cancer (OC) is one of the most common gynecological malignancies. MicroRNAs (miRs) play a crucial role in the development and progression of OC, but the underlying mechanism remains largely unclear. Our study investigated the regulatory role of miR-148a in OC cell proliferation and invasion. We found that miR-148a was significantly downregulated in OC tissues compared to their matched adjacent nontumor tissues. In addition, its expression was also reduced in OC cell lines (SKOV3, ES-2, OVCAR, and A2780) compared to normal ovarian epithelial cells. Overexpression of miR-148a caused a significant decrease in OC cell proliferation and invasion, as well as reduced MMP9 protein levels. Transforming growth factor-β-induced 2 (TGFI2) was further identified as a target gene of miR-148a, and its protein expression was downregulated in OC cells after miR-148a overexpression. Restoration of TGFI2 attenuated the suppressive effects of miR-148a on OC cell proliferation and invasion. Moreover, we found that TGFI2 was remarkably upregulated in OC tissues when compared with their matched adjacent nontumor tissues, and observed a reverse correlation between miR-148a and TGFI2 expression in OC tissues. On the basis of these findings, we suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, our study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC.
authors.affiliation: Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Xiamen UniversityXiamen, FujianChina.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics, Maternal and Child Health Hospital of Xiamen CityXiamen, FujianChina.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Hospital Infection-Control, The First Affiliated Hospital of Xiamen UniversityXiamen, FujianChina.
authors.forename: Shiyang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Early cancer screening center, The First Affiliated Hospital of Xiamen UniversityXiamen, FujianChina.
authors.forename: Liangjin
authors.initials: L
authors.lastname: Zhuang
authors.affiliation: Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Xiamen UniversityXiamen, FujianChina.
authors.forename: Yudi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Xiamen UniversityXiamen, FujianChina.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li