title: Efficacy of 0.2 μg/day fluocinolone acetonide implant (ILUVIEN) in eyes with diabetic macular edema and prior vitrectomy.
abstract: PurposeLimited data are available on the efficacy of the 0.2 μg/day fluocinolone acetonide (FAc) implant in eyes with prior vitrectomy. Here, we present a collection of 26 vitrectomized eyes treated with the 0.2 μg/day FAc implant.MethodsRetrospective study involving six centers from four European countries analyzing the safety and efficacy data from patients (26 eyes from 25 patients) with DME and a prior vitrectomy that had been treated with one 0.2 μg/day FAc implant.ResultsPrior intravitreal therapies included anti-VEGF (mean, 3.8 injections) and steroids (mean, 1.9 injections). Pars plana vitrectomy (PPV) was performed in these eyes primarily for abnormalities of vitreoretinal interface, followed by proliferative diabetic retinopathy and vitreous hemorrhage. The 0.2 μg/day FAc implant was injected 24.2 months, on average, after PPV and the mean duration of follow-up after injection was 255 days (range, 90 to 759 days). The mean change in BCVA was +11.7 ETDRS letters (range, -19 to +40 letters; P<0.0004) and the mean change in central foveal thickness (CFT) was -233.5 μm (range, -678 to 274 μm; P<0.0001). The mean change in IOP from baseline at the last visit was +1.4 mm Hg (range, -9 to +8 mm Hg; P=0.0090). Eight eyes initiated or continued IOP lowering medications.ConclusionsThese data suggest the 0.2 μg/day FAc implant is effective in vitrectomized patients with an acceptable safety profile. Further studies are still required to confirm the current findings and to assess the effect of the 0.2 μg/day FAc implant over a longer period of follow-up.
authors.affiliation: Unit of Ophthalmology, CHP-Hospital Santo António, Porto, Portugal.|Unit of Ophthalmology, Universidade do Porto-Instituto Ciências Biomédicas Abel Salazar, Porto, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Meireles
authors.affiliation: Unit of Ophthalmology, James Paget University Hospital, Great Yarmouth, UK.
authors.forename: C
authors.initials: C
authors.lastname: Goldsmith
authors.affiliation: Unit of Ophthalmology, James Cook University Hospital, Middlesbrough, UK.
authors.forename: I
authors.initials: I
authors.lastname: El-Ghrably
authors.affiliation: Unit of Ophthalmology, Lariboisiere University hospital, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Erginay
authors.affiliation: Unit of Ophthalmology, Sunderland Eye Hospital, Sunderland, UK.
authors.forename: M
authors.initials: M
authors.lastname: Habib
authors.affiliation: Unit of Ophthalmology, CHP-Hospital Santo António, Porto, Portugal.
authors.forename: B
authors.initials: B
authors.lastname: Pessoa
authors.affiliation: Unit of Ophthalmology, CHP-Hospital Santo António, Porto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Coelho
authors.affiliation: Unit of Ophthalmology, James Paget University Hospital, Great Yarmouth, UK.
authors.forename: T
authors.initials: T
authors.lastname: Patel
authors.affiliation: Unit of Ophthalmology, Lariboisiere University hospital, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Tadayoni
authors.affiliation: Unit of Ophthalmology, Lariboisiere University hospital, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Massin
authors.affiliation: Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Atorf
authors.affiliation: Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany.
authors.forename: A J
authors.initials: AJ
authors.lastname: Augustin
mesh_terms: D000368:Aged; D003930:Diabetic Retinopathy / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D058449:Intravitreal Injections; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D008297:Male; D057234:Preoperative Period; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide