title: The Role of Radiation Therapy in the Management of Sinonasal and Ventral Skull Base Malignancies.
abstract: Sinonasal and ventral skull base malignancies are rare tumors that arise in a complex anatomic location juxtaposed with critically important normal tissues. The standard treatment paradigm for most histologies has been surgery followed by postoperative radiation therapy. Because of their propensity to present at an advanced stage and the presence of nearby critical structures, patients are at risk for severe radiation-induced long-term toxicity. Recent advances in radiotherapy technique have improved the therapeutic ratio between tumor control and normal tissue toxicity. This article reviews issues pertinent to the use of radiotherapy in the management of these tumors.
authors.affiliation: Department of Radiation Oncology, University of North Carolina Hospitals, 101 Manning Drive, CB #7512, Chapel Hill, NC 27599-7512, USA.
authors.forename: Kyle
authors.initials: K
authors.lastname: Wang
authors.affiliation: Division of Head and Neck Surgery, Department of Otolaryngology, University of North Carolina Hospitals, 170 Manning Drive, CB #7070, Chapel Hill, NC 27599-7070, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Zanation
authors.affiliation: Department of Radiation Oncology, University of North Carolina Hospitals, 101 Manning Drive, CB #7512, Chapel Hill, NC 27599-7512, USA. Electronic address: bchera@med.unc.edu.
authors.forename: Bhishamjit S
authors.initials: BS
authors.lastname: Chera
mesh_terms: D004724:Endoscopy / Q000379:methods; D006801:Humans; D009296:Nasal Cavity / Q000528:radiation effects* / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000628:therapy*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods*; D019291:Skull Base / Q000528:radiation effects* / Q000601:surgery; D019292:Skull Base Neoplasms / Q000628:therapy*
keywords: Nasal cavity; Paranasal; Radiation; Sinonasal; Sinus; Skull base