title: Does the Age of Donor Kidneys Affect Nocturnal Polyuria in Patients With Successful Real Transplantation?
abstract: BACKGROUND
  We investigated whether the age of donor kidneys influences the incidence of nocturnal polyuria in patients with successful renal transplantation (RTX).
  
  
  METHODS
  Eighty-five patients (45 men and 40 women) undergoing RTX (median age, 47 years) were included in this study. Twenty-four-hour bladder diaries were kept for 3 days, and nocturnal polyuria was defined as a nocturnal polyuria index (nocturnal urine volume/24-hour urine volume) of >0.33. Risk factors for nocturnal polyuria were analyzed in patients with RTX by means of the Mann-Whitney U test, χ2test, and a logistic regression analysis.
  
  
  RESULTS
  End-stage renal disease (ESRD) developed from diabetes mellitus in 16 patients (19%). Sixty-five patients (76%) received pre-transplant dialysis, with a median duration of 5 years. The median serum creatinine level and body mass index at the most recent visit were 1.2 mg/dL and 21.2 kg/m2, respectively. On the basis of the 24-hour bladder diaries, nocturnal polyuria was identified in 48 patients (56%). A logistic regression analysis revealed that diabetes mellitus as the original disease for ESRD was the only risk factor for nocturnal polyuria (odds ratio, 8.95; 95% confidence interval, 2.01-65.3; P = .0028). The age of donor kidneys at examination did not affect the incidence of nocturnal polyuria (P = .9402).
  
  
  CONCLUSIONS
  Nocturnal polyuria was not uncommon in patients with successful RTX. Diabetes mellitus as the original disease for ESRD was the only risk factor for nocturnal polyuria, whereas the age of donor kidneys at examination did not affect the incidence of nocturnal polyuria. Thus, nocturnal polyuria is caused by recipient factors but not donor factors.
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan; Department of Urology, University of Yamanashi Graduate School of Medical Science, Yamanashi, Japan. Electronic address: tmitsui@yamanashi.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Mitsui
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Iwami
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kitta
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kanno
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Moriya
authors.affiliation: Department of Urology, University of Yamanashi Graduate School of Medical Science, Yamanashi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shinohara
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000453:epidemiology*; D011141:Polyuria / Q000453:epidemiology*; D012307:Risk Factors; D014019:Tissue Donors