title: Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis.
abstract: Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4+T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
authors.forename: Lina
authors.initials: L
authors.lastname: Mattson
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lentini
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
authors.forename: Danuta R
authors.initials: DR
authors.lastname: Gawel
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden; Bioinformatics, Department of Physics, Chemistry and Biology, Linkoping University, SE-581 83 Linkoping, Sweden.
authors.forename: Tejaswi V S
authors.initials: TV
authors.lastname: Badam
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Benson
authors.affiliation: Division of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden; Department of Otorhinolaryngology in Linkoping, Anaesthetics, Operations and Specialty Surgery Center, Region Ostergotland, Sweden.
authors.forename: Torbjorn
authors.initials: T
authors.lastname: Ledin
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
authors.forename: Colm E
authors.initials: CE
authors.lastname: Nestor
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden; Bioinformatics, Department of Physics, Chemistry and Biology, Linkoping University, SE-581 83 Linkoping, Sweden.
authors.forename: Mika
authors.initials: M
authors.lastname: Gustafsson
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
authors.forename: Jordi
authors.initials: J
authors.lastname: Serra-Musach
authors.affiliation: Futurum-Academy for Health and Care, County Council of Jonkoping, Jonkoping, Sweden.
authors.forename: Janne
authors.initials: J
authors.lastname: Bjorkander
authors.affiliation: Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Zou
authors.initials: Z
authors.lastname: Xiang
authors.affiliation: The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
authors.forename: Huan
authors.identifier: 0000-0001-9339-7999
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D029662:Betula / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016898:Interferon-alpha / Q000235:genetics / Q000276:immunology*; D016899:Interferon-beta / Q000235:genetics / Q000276:immunology*; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008875:Middle Aged; D011058:Pollen / Q000276:immunology; D025341:Principal Component Analysis; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000628:therapy; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000276:immunology; D050795:STAT2 Transcription Factor / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D016898:Interferon-alpha; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050795:STAT2 Transcription Factor; C494084:STAT2 protein, human; D016899:Interferon-beta; D007371:Interferon-gamma