title: Peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in adult-onset familial Mediterranean fever.
abstract: OBJECTIVE
  The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell-inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF).
  
  
  METHODS
  Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography. The patients were divided into two groups according to their disease severity score, M694V gene mutation, colchicine dosage used per day, colchicine usage time period and number of FMF attacks per year.
  
  
  RESULTS
  There were no statistically significant differences in peripapillary RNFL and retinal GCIPL thickness in patients with adult-onset FMF and controls.
  
  
  CONCLUSIONS
  According to our study, it looks like that neither adult-onset FMF nor colchicine has any effect on the RNFL and GCIPL thicknesses. Further studies with a large sample size are needed.
authors.affiliation: Department of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey. drsaitalim@gmail.com.
authors.forename: Sait
authors.identifier: http://orcid.org/0000-0003-1237-4264
authors.initials: S
authors.lastname: Alim
authors.affiliation: Department of Emergency Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Esen
authors.affiliation: Department of Internal Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Ayşe Kevser
authors.initials: AK
authors.lastname: Demir
authors.affiliation: Department of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: Department of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ortak
authors.affiliation: Department of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Güneş
authors.affiliation: Department of Emergency Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Tufan
authors.initials: T
authors.lastname: Alatli
authors.affiliation: Department of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Helin
authors.initials: H
authors.lastname: Deniz Demir
mesh_terms: D000328:Adult; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D003078:Colchicine / Q000008:administration & dosage; D004247:DNA; D004252:DNA Mutational Analysis; D004305:Dose-Response Relationship, Drug; D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D000071198:Pyrin / Q000235:genetics / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*; D050257:Tubulin Modulators / Q000008:administration & dosage
chemical_list: C000604192:MEFV protein, human; D000071198:Pyrin; D050257:Tubulin Modulators; D004247:DNA; D003078:Colchicine
keywords: Colchicine; Disease severity score; Ganglion cell–inner plexiform layer thickness; M694V gene mutation; Optical coherence tomography; Retinal nerve fiber layer thickness