title: Balancing Between Aging and Cancer: Molecular Genetics Meets Traditional Chinese Medicine.
abstract: The biological consequences of cellular senescence and immortalization in aging and cancer are in conflict. Organisms have developed common cellular signaling pathways and surveillance mechanisms to control the processing of aging against tumorigenesis. The imbalance of any signals involved in this process may result in either premature aging or tumorigenesis and reduce the life span of the organism. In contrast, the balance between aging and tumorigenesis at a higher level (homeostatic-balance) may benefit the organism with tumor-free longevity. The focus of this perspective is to review the literature on the balance between "Yin" and "Yang" in traditional Chinese medicine. Modern cellular and molecular techniques now permit a more robust system to screen herbs in traditional Chinese medicine for their activity in balancing aging and tumorigenesis. The understanding of the crosstalk between aging and tumorigenesis and new perspectives on the application of Chinese medicine might shed light on anti-aging and tumor-free strategies. J. Cell. Biochem. 118: 2581-2586, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Chenggong County, Kunming, Yunnan Province 650500, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Chenggong County, Kunming, Yunnan Province 650500, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Peng
authors.affiliation: Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Chenggong County, Kunming, Yunnan Province 650500, China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Huang
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Pan
authors.affiliation: Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Chenggong County, Kunming, Yunnan Province 650500, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Sang
authors.affiliation: Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Chenggong County, Kunming, Yunnan Province 650500, China.
authors.forename: Siqian
authors.initials: S
authors.lastname: Lu
authors.affiliation: Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Chenggong County, Kunming, Yunnan Province 650500, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, China.
authors.forename: Wanyi
authors.initials: W
authors.lastname: Li
authors.affiliation: Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Chenggong County, Kunming, Yunnan Province 650500, China.|Yunnan Provincial Institute of Digestive Disease, Kunming, Yunnan Province 650011, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008516:Medicine, Chinese Traditional; D008967:Molecular Biology; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D010946:Plants, Medicinal
keywords: DDR; SENESCENCS; STRESS; TELOMERASE; TUMORIGENESIS