title: An Orphan Riboswitch Unveils Guanidine Regulation in Bacteria.
abstract: In this issue, Nelson and colleagues (2017) determined that guanidine, the prevalent protein denaturant, is the long-lost ligand sensed by the ykkC class of riboswitches, and identified that members of its regulon are involved in guanidine detoxification and export.
authors.affiliation: Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Wendy W K
authors.initials: WWK
authors.lastname: Mok
authors.affiliation: Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address: mbrynild@princeton.edu.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Brynildsen
mesh_terms: D001419:Bacteria / Q000235:genetics; D019791:Guanidine; D006146:Guanidines; D012329:RNA, Bacterial; D058928:Riboswitch
chemical_list: D006146:Guanidines; D012329:RNA, Bacterial; D058928:Riboswitch; D019791:Guanidine