title: Osteoarthritis year in review 2016: biology.
abstract: This review highlights a selection of literature in the area of osteoarthritis biology published between the 2015 and 2016 Osteoarthritis Research Society International (OARSI) World Congress. Highlights were selected from a pubmed search covering cartilage, bone, inflammation and pain. A personal selection was made based, amongst other things, on topics presented during the 2015 conference. This covers circadian rhythm, TGF-β signaling, autophagy, SIRT6, exercise, lubricin, TLR's, pain and NGF. Furthermore, in this review we have made an effort to connect these seemingly distant topics into one scheme of connections between them, revealing a theoretical big picture underneath.
authors.affiliation: Radboudumc, Experimental Rheumatology, The Netherlands. Electronic address: Esmeralda.blaneydavidson@radboudumc.nl.
authors.forename: E N
authors.initials: EN
authors.lastname: Blaney Davidson
authors.affiliation: Radboudumc, Experimental Rheumatology, The Netherlands.
authors.forename: A P M
authors.initials: AP
authors.lastname: van Caam
authors.affiliation: Radboudumc, Experimental Rheumatology, The Netherlands.
authors.forename: P M
authors.initials: PM
authors.lastname: van der Kraan
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D015444:Exercise / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism / Q000503:physiopathology*; D037761:Sirtuins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D000099158:Proteoglycan 4
chemical_list: D006023:Glycoproteins; D037761:Sirtuins; D016212:Transforming Growth Factor beta; D000099158:Proteoglycan 4; C516592:SIRT6 protein, human
keywords: Cartilage; Inflammation; Osteoarthritis; Subchondral bone