title: Synthesis of 1-Thio-Substituted Isoquinoline Derivatives by Tandem Cyclization of Isothiocyanates.
abstract: A copper-catalyzed tandem arylation-cyclization process to access 1-(arylthio)isoquinolines from isothiocyanates and diaryliodonium salts is described. It is the first general method to construct the potentially useful 1-(arylthio)isoquinoline derivatives. Moreover, 1-(methylthio)isoquinoline derivatives were also achieved successfully with MeOTf instead of diaryliodonium salts under metal-free conditions. Mechanistic studies reveal that these two processes proceed in different routes. This method has been successfully applied to the synthesis of quinazolinone alkaloid rutaecarpine.
authors.affiliation: State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.|State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI) , Qingdao 266101, P. R. China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Wen
authors.affiliation: State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dou
authors.affiliation: State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.
authors.forename: Yuan-Chao
authors.initials: YC
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI) , Qingdao 266101, P. R. China.
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.|State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI) , Qingdao 266101, P. R. China.
authors.forename: Wei-Si
authors.initials: WS
authors.lastname: Guo
authors.affiliation: State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.
authors.forename: Ming
authors.identifier: 0000-0003-4906-936X
authors.initials: M
authors.lastname: Li