title: Polarization of microglia and its role in bacterial sepsis.
abstract: Microglial polarization in response to brain inflammatory conditions is a crescent field in neuroscience. However, the effect of systemic inflammation, and specifically sepsis, is a relatively unexplored field that has great interest and relevance. Sepsis has been associated with both early and late harmful events of the central nervous system, suggesting that there is a close link between sepsis and neuroinflammation. During sepsis evolution it is supposed that microglial could exert both neurotoxic and repairing effects depending on the specific microglial phenotype assumed. In this context, here it was reviewed the role of microglial polarization during sepsis-associated brain dysfunction.
authors.affiliation: Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Av Universitária, 1105, Criciúma 88806000, SC, Brazil. Electronic address: moniquemichels@hotmail.com.
authors.forename: Monique
authors.initials: M
authors.lastname: Michels
authors.affiliation: Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Av Universitária, 1105, Criciúma 88806000, SC, Brazil. Electronic address: biasonai@gmail.com.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sonai
authors.affiliation: Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Av Universitária, 1105, Criciúma 88806000, SC, Brazil; Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC), Graduate Program in Medical Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil. Electronic address: fdpizzol@gmail.com.
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D017628:Microglia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018805:Sepsis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
keywords: Microglia; Microglial polarization; Sepsis