title: HNE and cholesterol oxidation products in colorectal inflammation and carcinogenesis.
abstract: Consistent experimental data suggest the importance of inflammation-associated oxidative stress in colorectal cancer (CRC) pathogenesis. Inflammatory bowel disease with chronic intestinal inflammation is now considered a precancerous condition. Oxidative stress is an essential feature of inflammation. Activation of redox-sensitive pro-inflammatory cell signals and inflammatory mediators concur to establish a pro-tumoral environment. In this frame, lipid oxidation products, namely 4-hydroxynonenal and oxysterols, can be produced in big quantity so as to be able to exert their function as inducers of cell signaling pathways of proliferation and survival. Notably, an important source of these two compounds is represented by a high fat diet, which is undoubtedly a risk factor for inflammation and CRC development. Current evidence for the emerging implication of these two oxidized lipids in inflammation and CRC development is discussed in this review.
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin, Italy. Electronic address: darossin@unito.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Rossin
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin, Italy. Electronic address: simone.calfapietra@unito.it.
authors.forename: Simone
authors.initials: S
authors.lastname: Calfapietra
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin, Italy. Electronic address: barbara.sottero@unito.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sottero
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin, Italy. Electronic address: giuseppe.poli@unito.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Poli
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin, Italy. Electronic address: fiorella.biasi@unito.it.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Biasi
mesh_terms: D000447:Aldehydes / Q000378:metabolism*; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism; D003106:Colon / Q000378:metabolism / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D059305:Diet, High-Fat / Q000009:adverse effects; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D000072376:Oxysterols / Q000378:metabolism*; D012307:Risk Factors; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000447:Aldehydes; D016328:NF-kappa B; D000072376:Oxysterols; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D002784:Cholesterol; C027576:4-hydroxy-2-nonenal
keywords: 4-Hydroxynonenal; Antioxidant response; CRC; Colon; IBD; Intestinal; Oxysterols; Survival