title: SnapShot: Class 2 CRISPR-Cas Systems.
abstract: Class 2 CRISPR-Cas systems are characterized by effector modules consisting of single, large, multidomain proteins that appear to have been derived from mobile genetic elements. Some Class 2 effector proteins, such as Cas9 and Cas12a (Cpf1), have been successfully repurposed for genome engineering.
authors.affiliation: National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA.
authors.forename: Kira S
authors.initials: KS
authors.lastname: Makarova
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA.
authors.forename: Eugene V
authors.initials: EV
authors.lastname: Koonin
mesh_terms: D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000276:immunology*; D064113:CRISPR-Cas Systems; D004720:Endonucleases / Q000737:chemistry / Q000235:genetics; D000072669:Gene Editing
chemical_list: D004720:Endonucleases