title: Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma.
abstract: The phosphoinositide 3-kinase (PI3K) signaling pathway is the most commonly mutated pathway in head and neck squamous cell carcinoma (HNSCC). There are several drugs targeting members of the PI3K signaling pathway in development for HNSCC. In this article, we review the genetic alterations reported in the pathway pertinent to HNSCC, various agents in development targeting various mediators of the pathway, results from clinical trials, and remaining challenges in the development of PI3K pathway inhibitors.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Columbia University Medical Center, New York, NY, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Columbia University Medical Center, New York, NY, USA.
authors.forename: Sonam
authors.initials: S
authors.lastname: Dodhia
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Columbia University Medical Center, New York, NY, USA.|Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.|Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
authors.forename: Gloria H
authors.initials: GH
authors.lastname: Su
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors
keywords: PI3K inhibitor; PI3K signaling; PIK3CA mutation; head and neck squamous cell carcinoma; personalized medicine