title: Clinical observation on the treatment of acute liver failure by combined non-biological artificial liver.
abstract: The clinical efficacy and safety of different combinations of non-bio artificial liver in the treatment of acute liver failure was examined. A total of 61 cases were selected under blood purification treatment from the patients with severe acute liver failure admitted to the severe disease department of the hospital from December, 2010 to December, 2015. Three types of artificial liver combinations were observed, i.e., plasma exchange plus hemoperfusion plus continuous venovenous hemodiafiltration (PE+HP+CVVHDF), PE+CVVHDF and HP+CVVHDF. The heart rate (HR), mean arterial pressure (MAP), respiratory index (PaO2/FiO2), liver and kidney function indicator, as well as platelet and coagulation function were compared. A comparison before and after the treatment using the three methods, showed improvement in the HRs, MAPs, PaO2/FiO2, total bilirubins (TBIL) and alanine aminotransferases (ALT) (P<0.05), of which TBIL and ALT were decreased more significantly (P<0.01) in the PE+CVVHDF and PE+HP+CVVHDF groups. Only changes in the PE+HP+CVVHDF and PE+CVVHDF groups were statistically significant after prothrombin time and albumin treatment (P<0.05). The difference between the decrease in TBIL in the PE+HP+CVVHDF group and that in the HP+CVVHDF group was statistically significant (P<0.05). Treatment of the 61 patients using the artificial liver support system yielded a survival rate of 62.3% (38/61), and a viral survival rate of 35.0% (7/20); with the non-viral survival rate being 75.6% (31/41). In conclusion, following the treatment of three types of artificial livers, the function was improved to varying degrees, with the PE+HP+CVVHDF and the PE+CVVHDF method being better. By contrast, after the treatment of non-viral liver failure, the survival rate was significantly higher than the patients with viral liver failure.
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Maoqin
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Jingxi
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Jiaqiong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Zaixiang
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Jiyuan
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Shuli
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Intensive Care Unit, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical School of Xuzhou Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Xianjiang
authors.initials: X
authors.lastname: Zhang
keywords: acute liver failure; artificial liver; continuous veno - venous hemodiafiltration; hemoperfusion; plasmapheresis