title: [Radiofrequency ablation in combined treatment of metastatic colorectal liver cancer].
abstract: OBJECTIVE
  To study surgical and oncological outcomes in patients with metastatic colorectal liver cancer who underwent radiofrequency ablation in the structure of combined approach.
  
  
  METHODS
  It is a prospective analysis of treatment of 76 patients with metastatic colorectal liver cancer who underwent RFA for the period 2004-2013. Overall survival was analyzed using univariate and multivariate analysis.
  
  
  RESULTS
  According to univariate analysis overall 5-year survival is negatively determined by following factors: primary localization of the tumor in rectum (36.2% and 7.2%; p=0.021); bilobed metastatic liver disease (35.9% and 15.4%; p=0.068); metastases dimensions over 5 cm (27.4% and 0%, p=0.091); augmentation of CAE levels over 4 norms (26.7% and 11.4%, p=0.09); RFA as a component of two-stage liver surgery (23.3% and 26.0%, p=0.09).
  
  
  CONCLUSIONS
  RFA is an effective method of local antineoplastic effect for metastatic colorectal cancer. Dimensions of coagulated metastases, volume of metastatic lesion, carcinoembryonic antigen level, ablation as a component of two-stage surgery affect long-term survival after RFA.
authors.affiliation: Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
authors.forename: O G
authors.initials: OG
authors.lastname: Skipenko
authors.affiliation: Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
authors.forename: K N
authors.initials: KN
authors.lastname: Petrenko
authors.affiliation: Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
authors.forename: N N
authors.initials: NN
authors.lastname: Bagmet
authors.affiliation: Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
authors.forename: A L
authors.initials: AL
authors.lastname: Bedzhanyan
authors.affiliation: Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
authors.forename: L O
authors.initials: LO
authors.lastname: Polishchuk
authors.affiliation: Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
authors.forename: N K
authors.initials: NK
authors.lastname: Chardarov
authors.affiliation: Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
authors.forename: G A
authors.initials: GA
authors.lastname: Shatveryan
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D011446:Prospective Studies; D000078703:Radiofrequency Ablation; D016019:Survival Analysis