title: High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones.
abstract: Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[4]arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering. The correlation between photophysical and magnetic properties of the nanoparticles and their core composition was highlighted. The core composition was optimized for the longitudinal relaxivity to be greater than that of the commercial magnetic resonance imaging (MRI) contrast agents together with high level of Tb(III)-centered luminescence. The tuning of both magnetic and luminescent output of nanoparticles is obtained via the simple variation of lanthanide chelates concentrations in the initial synthetic solution. The exposure of the pheochromocytoma 12 (PC 12) tumor cells and periphery human blood lymphocytes to nanoparticles results in negligible effect on cell viability, decreased platelet aggregation and bright coloring, indicating the nanoparticles as promising candidates for dual magneto-fluorescent bioimaging.
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia.|Kazan (Volga region) Federal university, Kremlyovskaya str., 18, 420008, Kazan, Russia.
authors.forename: Rustem
authors.initials: R
authors.lastname: Zairov
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia.|Kazan (Volga region) Federal university, Kremlyovskaya str., 18, 420008, Kazan, Russia.
authors.forename: Asiya
authors.initials: A
authors.lastname: Mustafina
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia.|Kazan (Volga region) Federal university, Kremlyovskaya str., 18, 420008, Kazan, Russia.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Shamsutdinova
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia.|Kazan National Research Technological University, K. Marks str., 68, 420015, Kazan, Russia.
authors.forename: Irek
authors.initials: I
authors.lastname: Nizameev
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården4, 412 96 Gothenburg, Sweden.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Moreira
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Sudakova
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Podyachev
authors.affiliation: Kazan (Volga region) Federal university, Kremlyovskaya str., 18, 420008, Kazan, Russia.
authors.forename: Alfia
authors.initials: A
authors.lastname: Fattakhova
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården4, 412 96 Gothenburg, Sweden.|Division of Biological Physics, Department of Physics, Chalmers University of Technology, Kemigården1, 412 96 Gothenburg, Sweden.
authors.forename: Gulnara
authors.initials: G
authors.lastname: Safina
authors.affiliation: Division of Materials Science, Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.|Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden.
authors.forename: Ingemar
authors.initials: I
authors.lastname: Lundstrom
authors.affiliation: A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Arbuzov str., 8, 420088, Kazan, Russia.
authors.forename: Aidar
authors.initials: A
authors.lastname: Gubaidullin
authors.affiliation: Division of Materials Science, Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.
authors.forename: Alberto
authors.initials: A
authors.lastname: Vomiero