title: Significant Association of Serum Adiponectin and Creatine Kinase-MB Levels in ST-Segment Elevation Myocardial Infarction.
abstract: OBJECTIVE
  Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact of serum adiponectin concentration on acute ischemic myocardial damages has not been fully clarified. The present study investigated the association of serum adiponectin and creatine kinase (CK)-MB levels in subjects with ST-segment elevation myocardial infarction (STEMI).
  
  
  METHODS
  This study is a physician-initiated observational study and is also registered with the University Hospital Medical Information Network (Number: UMIN 000014418). Patients were admitted to Senri Critical Care Medical Center, given a diagnosis of STEMI, and treated by primary percutaneous coronary intervention (PCI). Finally, 49 patients were enrolled and the association of serum adiponectin, CK-MB, and clinical features were mainly analyzed.
  
  
  RESULTS
  Serum adiponectin levels decreased rapidly and reached the bottom at 24 hours after recanalization. Such reduction of serum adiponectin was inversely correlated with the area under the curve (AUC) of serum CK-MB (p=0.013). Serum adiponectin concentrations were inversely correlated with AUC of serum CK-MB. In multivariate analysis, serum adiponectin concentration on admission (p=0.002) and collateral (p=0.037) were significantly and independently correlated with serum AUC of CK-MB.
  
  
  CONCLUSIONS
  Serum AUC of CK-MB in STEMI subjects was significantly associated with serum adiponectin concentration on admission and reduction of serum adiponectin levels from baseline to bottom. The present study may provide a possibility that serum adiponectin levels at acute phase are useful in the prediction for prognosis after PCI-treated STEMI subjects.
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.|Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Natsukawa
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.|Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Maeda
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Shiro
authors.initials: S
authors.lastname: Fukuda
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Masaya
authors.initials: M
authors.lastname: Yamaoka
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Fujishima
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nagao
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Fumi
authors.initials: F
authors.lastname: Sato
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nishizawa
authors.affiliation: Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Sawano
authors.affiliation: Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.|Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University.
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.affiliation: Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Kai
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000473:pathology / Q000628:therapy
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D052279:Creatine Kinase, MB Form
keywords: Acute coronary syndrome; Adiponectin; CK-MB; Infarct size; Myocardial infarction