title: A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone.
abstract: In many bacteria, separate genes encode a copper binding chaperone and a copper efflux pump, but in some the chaperone encoding gene has been elusive. In this issue of Molecular Cell, Meydan et al. (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift and terminate to produce the copper chaperone.
authors.affiliation: School of Biochemistry and Cell Biology, University College Cork, Cork T12 YT57, Ireland; Department of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, USA. Electronic address: j.atkins@ucc.ie.
authors.forename: John F
authors.initials: JF
authors.lastname: Atkins
authors.affiliation: School of Biochemistry and Cell Biology, University College Cork, Cork T12 YT57, Ireland.
authors.forename: Gary
authors.initials: G
authors.lastname: Loughran
authors.affiliation: School of Biochemistry and Cell Biology, University College Cork, Cork T12 YT57, Ireland.
authors.forename: Pavel V
authors.initials: PV
authors.lastname: Baranov
mesh_terms: D001483:Base Sequence; D003300:Copper; D016368:Frameshift Mutation; D018965:Frameshifting, Ribosomal; D012367:RNA, Viral / Q000737:chemistry; D012270:Ribosomes / Q000235:genetics
chemical_list: D012367:RNA, Viral; D003300:Copper