title: Design and characterization of a combined OCT and wide field imaging falloposcope for ovarian cancer detection.
abstract: Early detection of ovarian cancer is only achieved in around 20% of women due to lack of effective screening. We propose a method for surveillance of high risk women based on a microendoscope introduced transvaginally to image the fallopian tubes and ovaries. This requires extreme miniaturization of the optics and catheter sheath. We describe the design of a falloposcope that combines optical coherence tomography (OCT) and wide field imaging into a sub-1 mm diameter package. We characterize the systems and show that they provide contrast onex-vivosamples of ovary and fallopian tube. In addition, we show the mechanical performance of the endoscope in an anatomically correct model of the female reproductive tract.
authors.affiliation: University of Arizona, Biomedical Engineering, 1127 James E Rogers Way, Tucson, AZ 85721, USA.
authors.forename: Molly
authors.initials: M
authors.lastname: Keenan
authors.affiliation: University of Arizona, College of Optical Sciences, 1630 East University Blvd., Tucson, AZ 85721, USA.
authors.forename: Tyler H
authors.initials: TH
authors.lastname: Tate
authors.affiliation: University of Arizona, College of Optical Sciences, 1630 East University Blvd., Tucson, AZ 85721, USA.
authors.forename: Khanh
authors.initials: K
authors.lastname: Kieu
authors.affiliation: Glannaventa Inc., 2276 Allegheny Way, San Mateo, CA 94402, USA.
authors.forename: John F
authors.initials: JF
authors.lastname: Black
authors.affiliation: University of Arizona, Biomedical Engineering, 1127 James E Rogers Way, Tucson, AZ 85721, USA; University of Arizona, College of Optical Sciences, 1630 East University Blvd., Tucson, AZ 85721, USA.
authors.forename: Urs
authors.initials: U
authors.lastname: Utzinger
authors.affiliation: University of Arizona, Biomedical Engineering, 1127 James E Rogers Way, Tucson, AZ 85721, USA; University of Arizona, College of Optical Sciences, 1630 East University Blvd., Tucson, AZ 85721, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Barton
keywords: (170.2150) Endoscopic imaging; (170.3890) Medical optics instrumentation; (170.4440) ObGyn; (170.4500) Optical coherence tomography