title: microRNAs in the pathophysiology of epilepsy.
abstract: Temporal lobe epilepsy is a common and often drug-resistant seizure disorder. The underlying pathological processes which give rise to the development of spontaneous seizures include neuroinflammation, cell loss, neurogenesis and dendritic abnormalities and many of these are driven by insult-induced changes in gene expression and gene expression regulation. MicroRNAs are powerful modulators of post-transcriptional gene expression which are dysregulated during epileptogenesis. The advent of locked nucleic acid (LNA) based inhibitory methods and mimic technology has facilitated in vivo functional assessment of these molecules in epilepsy. Here we review recent advances in our understanding of the role of these short non-coding RNAs in the pathophysiology of epilepsy.
authors.affiliation: Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland,123 St. Stephens Green, Dublin D02 YN77, Ireland.
authors.forename: Gary P
authors.initials: GP
authors.lastname: Brennan
authors.affiliation: Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland,123 St. Stephens Green, Dublin D02 YN77, Ireland. Electronic address: dhenshall@rcsi.ie.
authors.forename: David C
authors.initials: DC
authors.lastname: Henshall
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000235:genetics* / Q000503:physiopathology*; D005786:Gene Expression Regulation / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D055495:Neurogenesis / Q000235:genetics; D012640:Seizures / Q000235:genetics / Q000503:physiopathology*
chemical_list: D035683:MicroRNAs
keywords: Epigenetics; Hippocampal sclerosis; Noncoding RNA; Oligonucleotide