title: Niacinamide leave-on formulation provides long-lasting protection against bacteria in vivo.
abstract: Antimicrobial peptides (AMPs) form a part of the skin's innate immune system. Their primary activity is to provide antimicrobial benefits and hence protect from infections. AMPs that are present on human skin include psoriasin (S100A7), RNase 7, lysozyme, LL-37 and defensins. Niacinamide is a well-known cosmetic ingredient that has been used traditionally for multiple skin benefits. Recent data indicate that niacinamide treatment can boost AMPs in human gut epithelial cells and in neutrophils. Treatment with niacinamide in mice also provided protection from skin infections by enhancing AMPs. In this article, we find that treatment with niacinamide formulation provides long-lasting protection against bacteria, potentially through the activation of an AMP response.
authors.affiliation: Unilever R&D Bangalore, Bangalore, India.
authors.forename: Mruthyunjaya Swamy
authors.initials: MS
authors.lastname: Mathapathi
authors.affiliation: Unilever R&D Bangalore, Bangalore, India.
authors.forename: Prathyusha
authors.initials: P
authors.lastname: Mallemalla
authors.affiliation: Unilever R&D Bangalore, Bangalore, India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Vora
authors.affiliation: Unilever R&D Bangalore, Bangalore, India.
authors.forename: Vidula
authors.initials: V
authors.lastname: Iyer
authors.affiliation: Unilever R&D Bangalore, Bangalore, India.
authors.forename: Jyoti Kumar
authors.initials: JK
authors.lastname: Tiwari
authors.affiliation: Unilever R&D Bangalore, Bangalore, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Chakrabortty
authors.affiliation: Unilever R&D Bangalore, Bangalore, India.
authors.forename: Amitabha
authors.identifier: 0000-0003-2225-8398
authors.initials: A
authors.lastname: Majumdar
mesh_terms: D000328:Adult; D004926:Escherichia coli / Q000187:drug effects*; D064368:Healthy Volunteers; D006801:Humans; D009536:Niacinamide / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014803:Vitamin B Complex / Q000494:pharmacology*
chemical_list: D014803:Vitamin B Complex; D009536:Niacinamide
keywords: antimicrobial peptide; niacinamide; psoriasin; skin immunity