title: Migraine as a risk factor for young patients with ischemic stroke: a case-control study.
abstract: Studies have suggested a possible association of migraine and increased risk of ischemic stroke in young adults, particularly in smokers and in women who use oral contraceptive drugs. We aimed to analyze the association between migraine and ischemic stroke in young population in a hospital-based cohort. We included 202 consecutive patients with the diagnosis of ischemic stroke who were between 15 and 50 years and age- and gender-matched 250 volunteers with no history of stroke. All participants were interviewed using a questionnaire for migraine. Localization of ischemic lesion was classified as anterior and posterior circulation according to neuroimaging findings. The cause of ischemic lesion and all risk factors were recorded. Undetermined etiology was the most frequent (43.1%) and the most common determined cause was cardioembolism (22.3%) in young stroke patients. Frequency of migraine was 30.2% among patients with stroke whereas 16.8% of healthy subjects had migraine (p = 0.001). Migraine with aura was significantly more common among patients with stroke compared to healthy subjects (18.3 vs 4.4%; p = 0.000) whereas the frequency of migraine without aura was similar in both groups (11.9 vs 12.4%). Using logistic regression, migraine with aura was shown to be an independent risk factor for ischemic stroke in young population (p = 0.000) and separate analysis for gender demonstrated that it was only a risk factor for women (p = 0.009) but not for men (p = 0.107). Migraine with aura was found to be more common in ischemic stroke in young patients. It was an independent risk factor in women.
authors.affiliation: Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, K.M.Paşa, 34098, Istanbul, Turkey. yasinabanoz83@yahoo.com.
authors.forename: Yasin
authors.identifier: http://orcid.org/0000-0003-0726-5776
authors.initials: Y
authors.lastname: Abanoz
authors.affiliation: Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, K.M.Paşa, 34098, Istanbul, Turkey.
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Gülen Abanoz
authors.affiliation: Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, K.M.Paşa, 34098, Istanbul, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Gündüz
authors.affiliation: Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, K.M.Paşa, 34098, Istanbul, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Uludüz
authors.affiliation: Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, K.M.Paşa, 34098, Istanbul, Turkey.
authors.forename: Birsen
authors.initials: B
authors.lastname: İnce
authors.affiliation: Department of Psychiatry, School of Medicine, Acibadem University, Istanbul, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Yavuz
authors.affiliation: Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, K.M.Paşa, 34098, Istanbul, Turkey.
authors.forename: Baki
authors.initials: B
authors.lastname: Göksan
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002545:Brain Ischemia / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000453:epidemiology*; D020326:Migraine without Aura / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Migraine; Migraine with aura; Risk factors; Young ischemic stroke