title: Case Report of False-Negative Diffusion-Weighted Image of Brain Maggnetic Resonance Imaging (MRI) in Acute Ischemic Stroke.
abstract: BACKGROUND Acute ischemic stroke is a major cause of mortality and morbidity in Taiwan. Diffusion-weighted image (DWI) is a sensitive and common strategy used for imaging acute ischemic stroke. CASE REPORT We present a case of a negative DWI MRI for detecting acute ischemic stroke in a clinical setting. A 75-year-old male had a DWI performed after onset of symptoms suggesting acute ischemic stroke. The initial DWI result was negative at 72 hours of presentation. The neurological symptoms of the patient persisted and DWI was repeated. After 14 days, the DWI data confirmed and demonstrated an acute ischemic stroke. The delay in DWI confirmation, from symptom onset until DWI diagnosis, was 336 hours. CONCLUSIONS DWI may not have 100% sensitivity and accuracy in early stages of acute ischemic stroke. The time course to the development of abnormalities detected by DWI may be longer than anticipated.
authors.affiliation: Department of Neurology, Chang Hua Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Wei-Lun
authors.initials: WL
authors.lastname: Chang
authors.affiliation: Research Assistant Center, Chang Hua Show Chwan Health Care System, Changhua, Taiwan.
authors.forename: Ji-Ching
authors.initials: JC
authors.lastname: Lai
authors.affiliation: Research Assistant Center, Chang Hua Show Chwan Health Care System, Changhua, Taiwan.
authors.forename: Rong-Fu
authors.initials: RF
authors.lastname: Chen
authors.affiliation: Graduate Institute of Clinical Medicine and Department of Neurology, College of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan.
authors.forename: Han-Hwa
authors.initials: HH
authors.lastname: Hu
authors.affiliation: Department of Neurology, Chang Hua Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Chau-Shiung
authors.initials: CS
authors.lastname: Pan
mesh_terms: D000208:Acute Disease; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000175:diagnosis*; D005188:False Negative Reactions; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male