title: Pulse wave velocity and myocardial performance index in premature ovarian insufficiency.
abstract: OBJECTIVE
  Epidemiological studies suggest that women with loss of ovarian function at early ages may be especially burdened by cardiovascular disease (CVD). In this study, we aimed to evaluate pulse wave velocity (PWV) and myocardial performance index (MPI) in patients with premature ovarian insufficiency (POI).
  
  
  METHODS
  We enrolled 51 female patients (mean age 38.9 ± 6.7 years) with POI and 49 healthy subjects (mean age 36.8 ± 5.2 years). All participants underwent a detailed echocardiographic examination and PWV measurement, which is basically the velocity of pulse wave travelling from carotid to femoral artery.
  
  
  RESULTS
  Both groups were similar with regard to age, body mass index (BMI) and left ventricular ejection fraction. When diastolic functions were assessed, patients with POI had higher mean E/E'ratio (9.3 ± 1.9 vs. 7.6 ± 1.6, p < 0.001). POI patients have impaired MPI (0.9 ± 0.5 vs. 0.5 ± 0.2, p < 0.001) comparing to healthy controls but PWV measurements did not differ between two groups (5.7 ± 0.8 vs. 5.6 ± 0.6 m/s, p = 0.48).
  
  
  CONCLUSIONS
  This study showed POI patients might have impaired global left ventricular functions comparing to age matched healthy controls and this might reflect the effects of premature lack of estrogen (E) on women's cardiovascular (CV) system.
authors.affiliation: a Department of Cardiology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
authors.forename: Muhammed Necati Murat
authors.initials: MN
authors.lastname: Aksoy
authors.affiliation: b Department of Obstetrics and Gynecology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Akdemir
authors.affiliation: a Department of Cardiology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Kilic
authors.affiliation: a Department of Cardiology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
authors.forename: Sabiye
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: a Department of Cardiology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
authors.affiliation: a Department of Cardiology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Gunduz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D016649:Primary Ovarian Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D063177:Pulse Wave Analysis; D013318:Stroke Volume; D059289:Vascular Stiffness; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left
keywords: Premature ovarian insufficiency; diastolic functions; myocardial performance index; pulse wave velocity