title: Evaluation of a steroid releasing sinus implant for the treatment of patients undergoing frontal sinus surgery for chronic rhinosinusitis.
abstract: Management of the frontal sinus places great demands on the otolaryngologist. Given that the fronto-ethmoidal region is susceptible to recurrent inflammation, scarring, and stenosis, maintaining long-term patency of the frontal sinus is a difficult challenge. Oral and topical anti-inflammatory therapy, post-operative stenting, and 'home-brew' drug elution have been used for the treatment of the frontal sinus with mixed success. Recently an implant has been approved for post-operative placement into the frontal recess. This implant provides reliable and consistent steroid drug elution to address inflammation of the frontal recess secondary to chronic sinusitis. Areas covered: This review discusses the development and application of steroid eluting implants in the postoperative care of patients with chronic frontal sinusitis. All randomized controlled trials evaluating steroid eluting implants are discussed. Relevant supporting material discussing background, economics, safety are included. Expert commentary: Steroid eluting implants fulfill a unique niche in the treatment following frontal sinus surgery. They are shown to decrease the need for post-operative interventions and improve outcomes in patients with chronic sinusitis. There is significant potential for growth in the use of steroid eluting implants.
authors.affiliation: a Division of Otolaryngology , George Washington University , Washington , DC , USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Bury
authors.affiliation: a Division of Otolaryngology , George Washington University , Washington , DC , USA.
authors.forename: Ameet
authors.initials: A
authors.lastname: Singh
mesh_terms: D020341:Absorbable Implants / Q000009:adverse effects / Q000191:economics; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D065546:Drug Liberation; D005626:Frontal Sinus / Q000601:surgery*; D006801:Humans; D011358:Product Surveillance, Postmarketing; D012220:Rhinitis / Q000188:drug therapy* / Q000191:economics / Q000601:surgery*; D012852:Sinusitis / Q000188:drug therapy* / Q000191:economics / Q000601:surgery*; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D013256:Steroids
keywords: Chronic frontal sinusitis; frontal recess; mometasone furoate; steroid stent; steroid-eluting implant