title: A new dimeric stilbene from the lianas of Gnetum parvifolium.
abstract: A new dimeric stilbene, gnetifolin P (1), was isolated from the lianas of Gnetum parvifolium, together with seven known compounds 2-8. The structure of compound 1 was determined by extensive NMR and HRESIMS data analyses, and quantum chemical calculations. All the compounds were evaluated for their anti-inflammatory activity. Compounds 1 and 6 inhibited the expression of IL-1β on LPS induced THP-1 cells with the inhibition rate of 35.78 and 64.67%, respectively, at concentration of 25 μg/mL.
authors.affiliation: a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , People's Republic of China.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Tian
authors.affiliation: b Chemistry and Chemical Engineering college , Chongqing University , Chongqing , People's Republic of China.
authors.forename: Jun-Jiang
authors.initials: JJ
authors.lastname: Lv
authors.affiliation: a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: c Department of Pharmacy, Nangfang Hospital , Southern Medical University , Guangzhou , People's Republic of China.
authors.forename: Lu-Yao
authors.initials: LY
authors.lastname: Song
authors.affiliation: c Department of Pharmacy, Nangfang Hospital , Southern Medical University , Guangzhou , People's Republic of China.
authors.forename: Lian-Bing
authors.initials: LB
authors.lastname: Hou
authors.affiliation: a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhong
authors.affiliation: a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D035684:Gnetum / Q000737:chemistry*; D006801:Humans; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D053583:Interleukin-1beta; D013267:Stilbenes
keywords: ECD calculation; Gnetum parvifolium; anti-inflammatory activity; dimeric stilbene