title: Blood Pressure Trajectories From Childhood to Young Adulthood Associated With Cardiovascular Risk: Results From the 23-Year Longitudinal Georgia Stress and Heart Study.
abstract: The purpose of this study is to identify subgroups of individuals with similar trajectories in blood pressure (BP) from childhood to young adulthood and to determine the relationship of BP trajectories with carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). BP was measured ≤16 times during a 23-year period in 683 participants from childhood to young adulthood. IMT and LVMI were measured in 551 participants and 546 participants, respectively. Using latent class models, 3 trajectory groups in BP from childhood to young adulthood were identified, including high-increasing, moderate-increasing, and low-increasing groups. We found that trajectory of systolic BP was a significant predictor of both IMT and LVMI with increased rate of growth in systolic BP associated with higher levels of IMT and LVMI (Pfor trend<0.001). Similar to the BP trajectory groups from childhood to young adulthood, 3 trajectory groups in BP during childhood (≤18 years) were identified, and participants in the high-increasing group had thicker IMT (P<0.001) and increased LVMI (P=0.043) in comparison with those in the low-increasing group. Results were similar for mid-BP trajectories but not for diastolic BP trajectories. Our results suggested that different BP trajectories exist from childhood to young adulthood, and the trajectories were independently associated with IMT and LVMI. We, for the first time, reported the association between systolic BP trajectories derived from childhood with subclinical cardiovascular risk in young adulthood, indicating that monitoring trajectories of BP from childhood may help identify a high cardiovascular risk population in early life.
authors.affiliation: From the Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta University (G.H., X.W., G.H., G.K., S.S.); and Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.).
authors.forename: Guang
authors.initials: G
authors.lastname: Hao
authors.affiliation: From the Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta University (G.H., X.W., G.H., G.K., S.S.); and Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.).
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Wang
authors.affiliation: From the Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta University (G.H., X.W., G.H., G.K., S.S.); and Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.).
authors.forename: Frank A
authors.initials: FA
authors.lastname: Treiber
authors.affiliation: From the Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta University (G.H., X.W., G.H., G.K., S.S.); and Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.).
authors.forename: Gregory
authors.initials: G
authors.lastname: Harshfield
authors.affiliation: From the Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta University (G.H., X.W., G.H., G.K., S.S.); and Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.).
authors.forename: Gaston
authors.initials: G
authors.lastname: Kapuku
authors.affiliation: From the Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta University (G.H., X.W., G.H., G.K., S.S.); and Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.). ssu@augusta.edu.
authors.forename: Shaoyong
authors.initials: S
authors.lastname: Su
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000367:Age Factors; D001794:Blood Pressure / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000503:physiopathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005544:Forecasting; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
keywords: adolescent; adult; atherosclerosis; heart ventricles; hypertension; longitudinal study