title: Emerging functional roles of nuclear receptors in breast cancer.
abstract: Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting prognosis and determining therapeutic strategies. More recently, there is growing evidence supporting the involvement of multiple nuclear receptors other than the estrogen and progesterone receptors, in the regulation of various processes important to the initiation and progression of breast cancer. We review new insights into the mechanisms of action of NRs made possible by recent advances in genomic technologies and focus on the emerging functional roles of NRs in breast cancer biology, including their involvement in circadian regulation, metabolic reprogramming and breast cancer migration and metastasis.
authors.affiliation: Westmead Institute for Medical ResearchSydney Medical School - Westmead, University of Sydney, Sydney, New South Wales, Australia tram.doan@sydney.edu.au.
authors.forename: Tram B
authors.initials: TB
authors.lastname: Doan
authors.affiliation: Westmead Institute for Medical ResearchSydney Medical School - Westmead, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: J Dinny
authors.initials: JD
authors.lastname: Graham
authors.affiliation: Westmead Institute for Medical ResearchSydney Medical School - Westmead, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Clarke
mesh_terms: D000818:Animals; D015415:Biomarkers; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D065150:Cellular Reprogramming / Q000235:genetics; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D057906:Circadian Clocks / Q000235:genetics; D018450:Disease Progression; D004734:Energy Metabolism; D005260:Female; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D006801:Humans; D005810:Multigene Family; D009928:Organ Specificity / Q000235:genetics; D011485:Protein Binding; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D002843:Chromatin; D018160:Receptors, Cytoplasmic and Nuclear
keywords: breast cancer; circadian clock; metabolism; migration and metastasis; nuclear receptors