title: Effects of Acyzol on Zinc Content in Rat Brain and Blood Plasma.
abstract: Zinc level in the blood plasma and brain of rats was studied by inductively coupled plasma mass spectrometry. Maximum amount of zinc was observed in the cerebellum (15.0±5.5 μg/mg wet tissue). Single intraperitoneal administration of a zinc donor acyzol (24 mg/kg) did not change the content of this element in the tissues. Repeated injections of acyzol (7 injections over 14 days) significantly increased zinc level in rat plasma and brain. This elevation was most pronounced in the forebrain (cortex and subcortical structures). The rise in zinc concentration in blood plasma correlated with its level in the brain.
authors.affiliation: Laboratory of Physiology and Pathology of Motor Behavior, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia. jakin2010@gmail.com.|Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, St. Petersburg, Russia. jakin2010@gmail.com.
authors.forename: A F
authors.initials: AF
authors.lastname: Yakimoskii
authors.affiliation: Department of Bioindicators, A. M. Nikiforov All-Russian Center of Emergency and Radiation, Ministry of Emergency Situations, St. Petersburg, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Shantyr
authors.affiliation: Department of Bioindicators, A. M. Nikiforov All-Russian Center of Emergency and Radiation, Ministry of Emergency Situations, St. Petersburg, Russia.|Department of Biophysics, St. Petersburg State University, St. Petersburg, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Vlasenko
authors.affiliation: Department of Bioindicators, A. M. Nikiforov All-Russian Center of Emergency and Radiation, Ministry of Emergency Situations, St. Petersburg, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Yakovleva
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000737:chemistry / Q000378:metabolism*; D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D004334:Drug Administration Schedule; D007093:Imidazoles / Q000737:chemistry; D007274:Injections, Intraperitoneal; D008297:Male; D016548:Prosencephalon / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000008:administration & dosage* / Q000378:metabolism; D019345:Zinc Acetate / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism
chemical_list: D056831:Coordination Complexes; D007093:Imidazoles; D019345:Zinc Acetate; D015032:Zinc; C425704:N-vinylimidazole
keywords: acyzol; blood plasma; brain; zinc