title: Optimal glycemic target level for colon cancer patients with diabetes.
abstract: OBJECTIVE
  The aim of this study was to evaluate the differences in mortality among colon cancer patients with or without diabetes and to determine optimal glycemic target level for colon cancer patients with diabetes.
  
  
  METHODS
  A total of 741 patients with colon cancer between April 1999 and December 2010 were reviewed. The non-diabetes group had a fasting plasma glucose <126mg/dL, and the diabetes group had a fasting plasma glucose ⩾126mg/dL. Patients with diabetes were further divided based on glycemic control into either the uncontrolled subgroup (HbA1c ⩾8%) or the well-controlled subgroup (HbA1c <8%).
  
  
  RESULTS
  Patients with diabetes had significantly shorter overall survival and median survival than non-diabetes patients. Uncontrolled diabetes patients had significantly shorter overall survival and median survival than well-controlled diabetes patients. The relative risk of mortality for diabetes patients was higher than non-diabetes patients (relative risk 1.17). The relative risk of mortality in uncontrolled diabetes patients was significantly higher than in well-controlled diabetes patients (relative risk 4.58). The area under the curve for mortality and HbA1c level was 0.73. The cut off HbA1c level was 7.75%.
  
  
  CONCLUSIONS
  A optimal glycemic control level for colon cancer patients with diabetes should be recommended as an HbA1c of 7.8% or below.
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Gamcheonro 262, Seogu, Busan, South Korea.
authors.forename: Shin Jun
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Gamcheonro 262, Seogu, Busan, South Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Gamcheonro 262, Seogu, Busan, South Korea.
authors.forename: Seun Ja
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Gamcheonro 262, Seogu, Busan, South Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Ock
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Gamcheonro 262, Seogu, Busan, South Korea.
authors.forename: Su Kyoung
authors.initials: SK
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Gamcheonro 262, Seogu, Busan, South Korea.
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Gamcheonro 262, Seogu, Busan, South Korea. Electronic address: 79kyung@hanmail.net.
authors.forename: Bu Kyung
authors.initials: BK
authors.lastname: Kim
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000097:blood* / Q000150:complications / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000401:mortality*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism; D006040:Goals; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
keywords: Colon cancer; Diabetes mellitus; Glycemic control; Mortality