title: Fumarate reductase superfamily: A diverse group of enzymes whose evolution is correlated to the establishment of different metabolic pathways.
abstract: Fumarate and succinate are known to be present in prebiotic systems essential for the origin of life. The fumarate and succinate interconversion reactions have been conserved throughout evolution and are found in all living organisms. The fumarate and succinate interconversion is catalyzed by the enzymes succinate dehydrogenase (SDH) and fumarate reductase (FRD). In this work we show that SDH and FRD are part of a group of enzymes that we propose to designate "fumarate reductase superfamily". Our results demonstrate that these enzymes emerged from a common ancestor and were essential in the development of metabolic pathways involved in energy transduction.
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: douglas.messeder@gmail.com.
authors.forename: Douglas
authors.initials: D
authors.lastname: Jardim-Messeder
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: carol.cabreira@yahoo.com.br.
authors.forename: Caroline
authors.initials: C
authors.lastname: Cabreira-Cagliari
authors.affiliation: Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: rauber_rafa@yahoo.com.br.
authors.forename: Rafael
authors.initials: R
authors.lastname: Rauber
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: aturchetto@gmail.com.
authors.forename: Andreia Carina
authors.initials: AC
authors.lastname: Turchetto-Zolet
authors.affiliation: Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: rogerio.margis@ufrgs.br.
authors.forename: Rogério
authors.initials: R
authors.lastname: Margis
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: marcia.margis@ufrgs.br.
authors.forename: Márcia
authors.initials: M
authors.lastname: Margis-Pinheiro
mesh_terms: D005075:Biological Evolution; D001711:Biotransformation; D005650:Fumarates / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D013385:Succinate Dehydrogenase / Q000235:genetics* / Q000378:metabolism*; D013386:Succinates / Q000378:metabolism
chemical_list: D005650:Fumarates; D013386:Succinates; D013385:Succinate Dehydrogenase
keywords: Chloroplast; Endosymbiosis; Fumarate reductase; Mitochondria; Succinate dehydrogenase