title: Chronic Colovesical Fistula Leading to Chronic Urinary Tract Infection Resulting in End-Stage Renal Disease in a Chronic Granulomatous Disease Patient.
abstract: A 46-year old man with X-linked chronic granulomatous disease (CGD) being followed at the National Institute of Health with uncontrolled CGD colitis who developed chronic colovesical fistula, and end-stage renal disease (ESRD). Despite aggressive medical management of symptoms with immunomodulators and antibiotic prophylaxis, the chronic colovesical fistula led to chronic pyelonephritis, recurrent urinary tract infections, persistent air in the collecting system and bladder, and post-renal obstruction resulting in renal failure. Patient is now hemodialysis dependent and required diverting loop ileostomy placement. This report highlights multiple potential etiologies of rising serum creatinine in patients with CGD.
authors.affiliation: Urologic Oncology Branch, National Cancer Institute, NIH, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Siddiqui
authors.affiliation: Urologic Oncology Branch, National Cancer Institute, NIH, USA.
authors.forename: T
authors.initials: T
authors.lastname: Sanford
authors.affiliation: Urologic Oncology Branch, National Cancer Institute, NIH, USA.
authors.forename: A
authors.initials: A
authors.lastname: Nair
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, NIH, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Zerbe
authors.affiliation: Surgical Oncology Branch, National Cancer Institute, NIH, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Hughes
authors.affiliation: Radiology and Imaging and Sciences, Clinical Center, National Institutes of Health, USA.
authors.forename: L
authors.initials: L
authors.lastname: Folio
authors.affiliation: Urologic Oncology Branch, National Cancer Institute, NIH, USA.
authors.forename: Piyush K
authors.initials: PK
authors.lastname: Agarwal
authors.affiliation: University of Iowa, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Brancato
keywords: Chronic granulomatous disease; Colitis; Colovesical fistula; Post-renal obstruction; Pyelonephritis; Urinary tract infections