title: Serum insulin in pathogenesis and treatment of osteoarthritis.
abstract: Osteoarthritis (OA) is one of the major health problems that's development and progression is obesity-related. We believe that higher levels of insulin may explains this link especially. High levels of insulin in obesity and metabolic syndrome can induce numerous complications. Insulin can increase proliferation of chondrocyte but simultaneously, it prevents their differentiation. Moreover, hyperinsulinemia reduces the circulating level of serum T4 and conversion of T4 to T3, mimicking hypothyroidism, because thyroid hormones are necessary for the maturation of chondrocytes. So maybe decreasing insulin levels, prevents OA progression or improve the treatment process.
authors.affiliation: Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Askari
authors.affiliation: Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Ehrampoush
authors.affiliation: Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. Electronic address: r_homayounfar@yahoo.com.
authors.forename: Reza
authors.initials: R
authors.lastname: Homayounfar
authors.affiliation: Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Bahramali
authors.affiliation: Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Farjam
mesh_terms: D054392:Adipokines / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D019902:Chondrocytes / Q000166:cytology; D018450:Disease Progression; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism; D007249:Inflammation; D007328:Insulin / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications; D008962:Models, Theoretical; D009765:Obesity / Q000097:blood / Q000150:complications; D010003:Osteoarthritis / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy*; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D054392:Adipokines; D007328:Insulin; D014284:Triiodothyronine; D013974:Thyroxine
keywords: Adiponectins; Insulin; Metabolic syndrome; Osteoarthritis