title: Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study.
abstract: Resting-state functional connectivity (rsFC) is widely used to examine cerebral functional organization. The ventral striatum (VS) is critical to motivated behavior, with extant studies suggesting functional hemispheric asymmetry. The current work investigated differences in rsFC between the left (L) and right (R) VS and explored gender differences in the extent of functional lateralization. In 106 adults, we computed a laterality index (fcLI) to query whether a target region shows greater or less connectivity to the L vs R VS. A total of 45 target regions with hemispheric masks were examined from the Automated Anatomic Labeling atlas. One-sample t test was performed to explore significant laterality in the whole sample and in men and women separately. Two-sample t test was performed to examine gender differences in fcLI. At a corrected threshold (p < 0.05/45 = 0.0011), the dorsomedial prefrontal cortex (dmPFC) and posterior cingulate cortex (pCC) showed L lateralization and the intraparietal sulcus (IPS) and supramarginal gyrus (SMG) showed R lateralization in VS connectivity. Except for the pCC, these findings were replicated in a different data set (n = 97) from the Human Connectome Project. Furthermore, the fcLI of VS-pCC was negatively correlated with a novelty seeking trait in women but not in men. Together, the findings may suggest a more important role of the L VS in linking saliency response to self control and other internally directed processes. Right lateralization of VS connectivity to the SMG and IPS may support attention and action directed to external behavioral contingencies.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, CMHC S112, 34 Park Street, New Haven, CT, 06519-1109, USA.
authors.forename: Sheng
authors.identifier: http://orcid.org/0000-0001-5786-6516
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, CMHC S112, 34 Park Street, New Haven, CT, 06519-1109, USA.
authors.forename: Sien
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.|Veterans Administration Medical Center, West Haven, CT, USA.
authors.forename: Herta H
authors.initials: HH
authors.lastname: Chao
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, CMHC S112, 34 Park Street, New Haven, CT, 06519-1109, USA. chiang-shan.li@yale.edu.|Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. chiang-shan.li@yale.edu.|Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, USA. chiang-shan.li@yale.edu.
authors.forename: Chiang-Shan R
authors.initials: CR
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D001931:Brain Mapping / Q000379:methods; D054022:Cerebrum / Q000000981:diagnostic imaging / Q000502:physiology*; D005106:Exploratory Behavior; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology*; D010551:Personality; D012737:Sex Factors; D066328:Ventral Striatum / Q000000981:diagnostic imaging / Q000502:physiology*; D055815:Young Adult
keywords: Hemisphericity; Laterality; RsFC; Sex difference; Ventral striatum