title: Radiation absorbed dose estimates for 18F-BPA PET.
abstract: Background Boron neutron capture therapy (BNCT) is a molecular radiation therapy approach based on the10B (n, α)7Li nuclear reaction in cancer cells. In BNCT, delivery of10B in the form of 4-borono-phenylalanine conjugated with fructose (BPA-fr) to the cancer cells is important. The PET tracer 4-borono-2-18F-fluoro-phenylalanine (FBPA) has been used to predict the accumulation of BPA-fr before BNCT. Purpose To determine the biodistribution and dosimetric parameters in 18F-BPA PET/CT studies. Material and Methods Human biokinetic data were obtained during clinical 18F-BPA PET studies between February and June 2015 at one institution. Nine consecutive patients were studied prospectively. The internal radiation dose was calculated on the basis of radioactivity data from blood, urine, and normal tissue of the heart, liver, spleen, kidney, and other parts of the body at each time point using OLINDA/EXM1.1 program. We compared our calculations with published 18F-FDG data. Results Adult patients (3 men, 3 women; age range, 28-68 years) had significantly smaller absorbed doses than pediatric patients (3 patients; age range, 5-12 years) ( P = 0.003). The mean effective dose was 57% lower in adult patients compared with pediatric patients. Mean effective doses for 18F-BPA were 25% lower than those for 18F-FDG presented in International Commission of Radiation Protection (ICRP) publication 106. Conclusion We found significant differences in organ absorbed doses for 18F-BPA against those for 18F-FDG presented in ICRP publication 106. Mean effective doses for 18F-BPA were smaller than those for 18F-FDG in the publication by 0.5-38% (mean difference, 25%).
authors.affiliation: 1 Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kono
authors.affiliation: 1 Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: 2 Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawamoto
authors.affiliation: 2 Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Yasui
authors.affiliation: 3 Department of Pharmacy, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Honda
authors.affiliation: 4 Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Igaki
authors.affiliation: 4 Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Itami
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001896:Boron Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005462:Fluorine Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006020:Glycopeptides / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D011446:Prospective Studies; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted
chemical_list: C504600:4-borono-2-fluorophenylalaninefructose; D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D006020:Glycopeptides
keywords: 18F-BPA PET; Boron neutron capture therapy (BNCT); effective dose; radiation absorbed dose