title: Shape and geometry control of the Drosophila tracheal tubule.
abstract: For efficient respiration, tubular airways must be constructed with an optimal diameter and length for the dimensions of the body. In Drosophila, the growth of embryonic tracheal tubules proceeds in two dimensions, by axial elongation and diameter expansion. The growth forces in each dimension are controlled by distinct genetic programs and cellular mechanisms. Recent studies reveal that the apical cortex and the apical extracellular matrix filling the luminal space are essential for the generation, balancing, and equilibrium of these growth forces. We here discuss the mechanical properties and architecture of the apical cortex and extracellular matrix, and their crucial roles in the tissue-level coordination of tubule shape and geometry.
authors.affiliation: Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan.|Department of Biology, Kobe University Graduate School of Science, Kobe, Hyogo, Japan.
authors.forename: Shigeo
authors.identifier: http://orcid.org/0000-0001-7785-1290
authors.initials: S
authors.lastname: Hayashi
authors.affiliation: Ministry of Education Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China.|Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Shandong, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Dong
mesh_terms: D000825:Animal Structures / Q000033:anatomy & histology* / Q000196:embryology*; D000818:Animals; D004330:Drosophila
keywords: extracellular matrix; size control; tubulogenesis; viscoelasticity