title: Microbubbles: A Novel Strategy for Chemotherapy.
abstract: Ultrasound microbubbles have conventionally been used for diagnostic purposes. In recent years, however, new types of microbubbles have emerged as important carriers for drug delivery. Moreover, studies have shown that ultrasound microbubbles can serve as valuable and noninvasive tools in cancer therapy; thus the use of ultrasound microbubbles to deliver chemotherapeutic drugs to malignant tissues is a promising possibility.
  
  
  
  In this review, we briefly describe the status of ultrasound microbubbles in clinical practice and then discuss the development of targeted microbubbles. Finally, we consider novel strategies for the use of microbubbles in cancer therapy.
  
  
  
  Many different kinds of microbubbles are emerged. Novel strategies of ultrasound microbubble have been shown to be effective in cancer therapy.
  
  
  
  Although many problems need to be solved in the future, the ultrasound drugs loaded microbubbles still have strong potential for the use in clinical cancer therapy.
authors.affiliation: Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150. China.
authors.forename: Mu-Hua
authors.initials: MH
authors.lastname: Luo
authors.affiliation: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Kuang-Fu Road, Hsinchu, 30013. Taiwan.
authors.forename: Chih-Kuang
authors.initials: CK
authors.lastname: Yeh
authors.affiliation: Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Situ
authors.affiliation: Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150. China.
authors.forename: Jin-Sui
authors.initials: JS
authors.lastname: Yu
authors.affiliation: Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150. China.
authors.forename: Bing-Cheng
authors.initials: BC
authors.lastname: Li
authors.affiliation: Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150. China.
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D006801:Humans; D045423:Microbubbles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D014464:Ultrasonic Therapy / Q000379:methods / Q000639:trends
chemical_list: D000970:Antineoplastic Agents
keywords: Ultrasound microbubbles; cancer therapy; chemotherapy; drug delivery; malignant tissues; molecular imaging