title: [Associations between airflow obstruction and total and cause-specific mortality in adults in China].
abstract: Objective:To examine the prospective associations between airflow obstruction and total and cause-specific mortality.Methods:The study was based on China Kadoorie Biobank, in which 199 099 men and 287 895 women aged 30-79 years at baseline survey were included after excluding those with heart disease, stroke and cancer. The Global Initiative on Obstructive Lung Disease (GOLD) guideline was used to classify airflow obstruction. Cox regression models were used to estimate adjustedHRand 95%CI.Results:During 3 494 079 person-years of follow-up between 2004 and 2013 (median 7.2 years), a total of 21 649 people died. Absolute mortality rates were 5.5, 9.9, 13.1, 32.4 and 63.3 deaths per 1 000 person-years for participants who had normal airflow, GOLD-1 to GOLD-4 airflow obstruction, respectively. After adjusting potential confounders, compared with participants with normal lung function, theHRs for death were 0.98 (95%CI: 0.88-1.09), 1.03 (95%CI: 0.97-1.09), 1.62 (95% CI: 1.53-1.73) and 2.83 (95% CI: 2.59-3.10) for those whose airflow obstruction were classified as GOLD-1 to GOLD-4, respectively. The airflow obstruction was also associated with increased risk for deaths due to ischemic heart disease, cerebrovascular disease and chronic obstructive pulmonary disease.Conclusion:Airflow obstruction is associated with total and certain cause-specific mortality, the higher the airflow obstruction degree is, the higher the death risk is.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: F L
authors.initials: FL
authors.lastname: Lan
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: J C
authors.initials: JC
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Yu
authors.affiliation: Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Bian
authors.affiliation: Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Tan
authors.affiliation: Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: P
authors.initials: P
authors.lastname: Pei
authors.affiliation: China National Center for Food Safety Risk Assessment, Beijing 100022, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Chen
authors.affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX12JD, UK.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: W H
authors.initials: WH
authors.lastname: Cao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: J
authors.initials: J
authors.lastname: Lyu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: L M
authors.initials: LM
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality; D009369:Neoplasms / Q000401:mortality; D016016:Proportional Hazards Models; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000401:mortality*
keywords: Airflow obstruction; Chronic disease; Chronic obstructive pulmonary disease; Death