title: Novel surface-engineered solid lipid nanoparticles of rosuvastatin calcium for low-density lipoprotein-receptor targeting: a Quality by Design-driven perspective.
abstract: OBJECTIVE
  The present studies describe Quality by Design-oriented development and characterization of surface-engineered solid lipid nanoparticles (SLNs) of rosuvastatin calcium for low density lipoprotein-receptor targeting.
  
  
  METHODS
  SLNs were systematically prepared employing Compritol 888 and Tween-80. Surface modification of SLNs was accomplished with Phospholipon 90G and DSPE-mPEG-2000 as the ligands for specific targeting to the low density lipoprotein-receptors. SLNs were evaluated for size, potential, entrapment, drug release performance and gastric stability. Also, the formulations were evaluated for cellular cytotoxicity, uptake and permeability, pharmacokinetic, pharmacodynamic and biochemical studies.
  
  
  CONCLUSIONS
  Overall, the studies ratified enhanced biopharmaceutical performance of the surface-engineered SLNs of rosuvastatin as a novel approach for the management of hyperlipidemia-like conditions.
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014, India.
authors.forename: Sarwar
authors.initials: S
authors.lastname: Beg
authors.affiliation: Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research, Mohali 160 062, Punjab, India.
authors.forename: Sanyog
authors.initials: S
authors.lastname: Jain
authors.affiliation: Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research, Mohali 160 062, Punjab, India.
authors.forename: Varun
authors.initials: V
authors.lastname: Kushwah
authors.affiliation: UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh 160 014, India.
authors.forename: Gurjit Kaur
authors.initials: GK
authors.lastname: Bhatti
authors.affiliation: UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh 160 014, India.
authors.forename: Premjeet Singh
authors.initials: PS
authors.lastname: Sandhu
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014, India.
authors.forename: O P
authors.initials: OP
authors.lastname: Katare
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014, India.|UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh 160 014, India.
authors.forename: Bhupinder
authors.initials: B
authors.lastname: Singh
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D018938:Caco-2 Cells; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism*; D017208:Rats, Wistar; D011973:Receptors, LDL / Q000378:metabolism*; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000924:Anticholesteremic Agents; D004337:Drug Carriers; D010713:Phosphatidylcholines; D011973:Receptors, LDL; C585968:phospholipon 90G; D000068718:Rosuvastatin Calcium
keywords: Quality by Design; cellular uptake; hyperlipidemia; nanomedicine; phospholipid; targeting