title: Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.
abstract: Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC500.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa , Honolulu, Hawaii 96822, United States.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Parrish
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa , Honolulu, Hawaii 96822, United States.
authors.forename: Wesley
authors.initials: W
authors.lastname: Yoshida
authors.affiliation: University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawaii 96813, United States.
authors.forename: Baojun
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa , Honolulu, Hawaii 96822, United States.|University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawaii 96813, United States.
authors.forename: Philip G
authors.identifier: 0000-0001-8987-0683
authors.initials: PG
authors.lastname: Williams
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D049851:Gastropoda / Q000737:chemistry*; D006254:Hawaii; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D010063:Ovum / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D010080:Oxazoles; C000621261:ulapualide C; C000621262:ulapualide D; C000621263:ulapualide E