title: Incidence and predictors of left ventricular remodeling among elderly Asian women: a community-based cohort study.
abstract: Left ventricular (LV) remodeling is closely linked to the progression of heart failure. There are limited data on the epidemiology of new onset LV remodeling among elderly women, which requires further investigation.
  
  
  
  We examined data from a community-based cohort of women aged > 65 years, who had received > 2 echocardiography scans from 2009 to 2014. Exclusion criteria for patients included prior echocardiographic evidence of left ventricular enlargement (LVE) or hypertrophy (LVH). LVE was defined as the index of left ventricular internal diameter at end-diastole to height, and LVH was defined as the left ventricular mass and thickness index which indicate hypertrophy.
  
  
  
  Of the 474 subjects (age 71.85 ± 6.47 years), 49 (10.3%) developed LVH, while 55 (11.6%) developed LVE during the mean follow-up period of 5 years. Independent predictors of LVH included: central blood pressure (CBP, per 10 mmHg) [HR 1.094, 95% CI 1.011-1.202], BMI˃25(kg/m2)[HR 1.306, 95% CI 1.175-1.434], B-type natriuretic peptide (BNP) ≥ 100 (pg/mL) [HR 1.635, 95% CI 1.107-3.311] and brachial-ankle pulse wave velocity (baPWV) ≥16 m/s [HR 1.605, 95% CI 1.474-2.039]. Predictors of LVE were CBP (per 10 mmHg) [HR 1.121, 95% CI 1.027-1.238], BMI˃25(kg/m2)[HR 1.302, 95% CI 1.173-1.444], Low-density lipoprotein cholesterol (LDL-C) [HR 1.193, 95%CI 1.013-1.405] and E/e' ratio [HR 1.077, 95% CI 1.017-1.140].
  
  
  
  CBP and BMI were demonstrated to be independent and robust predictors of left ventricular remodeling among elderly women, including both LVE and LVH. BNP and baPWV were specifically related to the development of LVH, whereas LDL-C and E/e' ratio were related to LVE.
authors.affiliation: School of Nursing, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Nursing, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai, People's Republic of China.
authors.forename: Caiqin
authors.initials: C
authors.lastname: Wu
authors.affiliation: School of Nursing, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai, People's Republic of China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Fan
authors.affiliation: School of Nursing, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai, People's Republic of China. allydata88@126.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, People's Republic of China. xulq67@126.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D044466:Asian People; D001794:Blood Pressure; D002681:China; D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology*; D015994:Incidence; D020097:Natriuretic Peptide, Brain / Q000097:blood; D063177:Pulse Wave Analysis; D020257:Ventricular Remodeling
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: Cohort; Elderly; Left ventricular enlargement; Left ventricular hypertrophy; Predictor; Women