title: Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R.
abstract: Novel 4-benzylamino benzo-anellated pyrrolo[2,3-b]pyridines have been synthesized with varied substitution patterns both at the molecular scaffold of the benzo-anellated ring and at the 4-benzylamino residue. With a structural similarity to substituted thieno[2,3-d]pyrimidines as epidermal growth factor receptor (EGFR) inhibitors, we characterized the inhibition of EGFR for our novel compounds. As receptor heterodimerization gained certain interest as mechanism of cancer cells to become resistant against novel protein kinase inhibitors, we additionally measured the inhibition of insulin-like growth factor receptor IGF-1R which is a prominent receptor for such heterodimerizations with EGFR. Structure-activity relationships are discussed for both kinase inhibitions depending on the varied substitution patterns. We discovered novel dual inhibitors of both receptor tyrosine kinases with interest for further studies to reduce inhibitor resistance developments in cancer treatment.
authors.affiliation: a Department of Pharmaceutical Chemistry , Institute of Pharmacy, Martin Luther University , Halle , Germany.
authors.forename: Cornelius
authors.initials: C
authors.lastname: Hempel
authors.affiliation: b ProQinase GmbH, Freiburg , Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Totzke
authors.affiliation: b ProQinase GmbH, Freiburg , Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schächtele
authors.affiliation: a Department of Pharmaceutical Chemistry , Institute of Pharmacy, Martin Luther University , Halle , Germany.
authors.forename: Abdulkarim
authors.initials: A
authors.lastname: Najjar
authors.affiliation: a Department of Pharmaceutical Chemistry , Institute of Pharmacy, Martin Luther University , Halle , Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sippl
authors.affiliation: c Department of Clinical Pharmacy , Institute of Pharmacy, Ernst Moritz Arndt University Greifswald , Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Ritter
authors.affiliation: a Department of Pharmaceutical Chemistry , Institute of Pharmacy, Martin Luther University , Halle , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hilgeroth
mesh_terms: D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D066244:Proton Magnetic Resonance Spectroscopy; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D004791:Enzyme Inhibitors; D066246:ErbB Receptors; D017526:Receptor, IGF Type 1
keywords: Benzo-anellated compounds; biological activity; protein kinase inhibitory activity