title: P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II.
abstract: The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.
authors.affiliation: a State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Xiamen University , Xiamen , China.
authors.forename: You
authors.initials: Y
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Xiamen University , Xiamen , China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: b Department of Biochemistry , College of Medicine, University of Illinois at Urbana-Champaign , Urbana , IL , USA.
authors.forename: Lin-Feng
authors.identifier: 0000-0003-1809-1580
authors.initials: LF
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Xiamen University , Xiamen , China.
authors.forename: Ruichuan
authors.initials: R
authors.lastname: Chen
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D042925:Positive Transcriptional Elongation Factor B / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D042925:Positive Transcriptional Elongation Factor B; D012319:RNA Polymerase II
keywords: 7SK snRNP; Brd4; KAP1; P-TEFb; RNA Pol II; SEC; promoter-proximal pausing; transcription elongation