title: Ginsenoside Rg3 Improves Cardiac Function after Myocardial Ischemia/Reperfusion via Attenuating Apoptosis and Inflammation.
abstract: Objectives. Ginsenoside Rg3 is one of the ginsenosides which are the main constituents isolated fromPanax ginseng. Previous study demonstrated that ginsenoside Rg3 had a protective effect against myocardial ischemia/reperfusion- (I/R-) induced injury.Objective. This study was designed to evaluate the effect of ginsenoside Rg3 on cardiac function impairment induced by myocardial I/R in rats.Methods. Sprague-Dawley rats were subjected to myocardial I/R. Echocardiographic and hemodynamic parameters and histopathological examination were carried out. The expressions of P53, Bcl-2, Bax, and cleaved caspase-3 and the levels of TNF-αand IL-1βin the left ventricles were measured.Results. Ginsenoside Rg3 increased a left ventricular fractional shortening and left ventricular ejection fraction. Treatment with ginsenoside Rg3 also alleviated increases of left ventricular end diastolic pressure and decreases of left ventricular systolic pressure and ±dp/dt in myocardial I/R-rats. Ginsenoside Rg3 decreased apoptosis cells through inhibiting the activation of caspase-3. Ginsenoside Rg3 also caused significant reductions of the contents of TNF-αand IL-1βin left ventricles of myocardial I/R-rats.Conclusion. The findings suggested that ginsenoside Rg3 possessed the effect of improving myocardial I/R-induced cardiac function impairment and that the mechanism of pharmacological action of ginsenoside Rg3 was related to its properties of antiapoptosis and anti-inflammation.
authors.affiliation: Departments of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
authors.affiliation: Departments of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China.
authors.forename: Yi-Chuan
authors.initials: YC
authors.lastname: Jiang
authors.affiliation: Departments of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Yu
authors.affiliation: Departments of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China.
authors.forename: Hua-Li
authors.initials: HL
authors.lastname: Xu
authors.affiliation: Departments of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Departments of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Xue-Zhong
authors.identifier: 0000-0003-3485-0575
authors.initials: XZ
authors.lastname: Zhao
authors.affiliation: Departments of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China.
authors.forename: Da-Yuan
authors.identifier: 0000-0003-4615-6943
authors.initials: DY
authors.lastname: Sui