title: Core-Shell Metal-Organic Frameworks/Molecularly Imprinted Nanoparticles as Absorbents for the Detection of Pyrraline in Milk and Milk Powder.
abstract: A novel core-shell metal-organic framework coated with a dummy template molecularly imprinted polymer (MOF@DMIP) was synthesized by one-pot bulk polymerization for the detection of pyrraline in food samples. The pyrraline analogue pyrrolidine-3-carboxylic acid was used as the template because of its lower cost, and MIL-101 was used as the MOF core owing to its numerous inherent advantages, including high chemical and hydrothermal stabilities. MIL-101@DMIP was used to detect trace pyrraline in foods by solid-phase extraction combined with high-performance liquid chromatography. It exhibited the advantages of faster mass transport, excellent sensitivity, and selectivity. Under optimum conditions, the detection limit of this system was 40.7 μg L-1, and a linear range was from 5 × 10-7to 2 × 10-3mol L-1, within relative standard deviations of 4.46-6.87%. The recoveries ranged from 92.23 to 103.87%, indicating the excellent ability of the prepared MIL-101@DMIP to recognize pyrraline in complex food matrices and its potential for application in pyrraline detection.
authors.affiliation: Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU) , 11 Fucheng Road, Beijing 100048, China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Liu
authors.affiliation: Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU) , 11 Fucheng Road, Beijing 100048, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Mu
authors.affiliation: Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU) , 11 Fucheng Road, Beijing 100048, China.
authors.forename: Xiaomo
authors.initials: X
authors.lastname: Chen
authors.affiliation: Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU) , 11 Fucheng Road, Beijing 100048, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU) , 11 Fucheng Road, Beijing 100048, China.|Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, Tianjin University of Science and Technology , Tianjin 300457, China.
authors.forename: Shuo
authors.identifier: http://orcid.org/0000-0003-0910-6146
authors.initials: S
authors.lastname: Wang
authors.affiliation: Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU) , 11 Fucheng Road, Beijing 100048, China.
authors.forename: Baoguo
authors.initials: B
authors.lastname: Sun
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D005506:Food Contamination / Q000032:analysis*; D057230:Limit of Detection; D008892:Milk / Q000737:chemistry*; D054802:Molecular Imprinting; D053758:Nanoparticles / Q000737:chemistry*; D009646:Norleucine / Q000031:analogs & derivatives* / Q000032:analysis / Q000302:isolation & purification; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011208:Powders / Q000737:chemistry; D011758:Pyrroles / Q000032:analysis / Q000302:isolation & purification*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*
chemical_list: D011108:Polymers; D011208:Powders; D011758:Pyrroles; C059571:2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine; D009646:Norleucine
keywords: HPLC; advanced glycation end products; metal−organic frameworks; molecularly imprinted polymer; pyrraline; solid-phase extraction