title: Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome.
abstract: To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.
  
  
  
  Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.
  
  
  
  The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 ± 10.1 vs 22.3 ± 11.5, respectively, p = 0.014).
  
  
  
  Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.
authors.affiliation: a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tetikoğlu
authors.affiliation: a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Aktas
authors.affiliation: a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
authors.forename: Haci Murat
authors.initials: HM
authors.lastname: Sağdik
authors.affiliation: a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Özcura
authors.affiliation: b Department of Biochemistry , Dışkapı Yıldırım Beyazit Training and Research Hospital , Ankara , Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Uçar
authors.affiliation: c Department of Biochemistry , Dumlupinar University School of Medicine , Kutahya , Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Koçak
authors.affiliation: d Department of Biochemistry , Yıldırım Beyazit University , Ankara , Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neşelioğlu
authors.affiliation: d Department of Biochemistry , Yıldırım Beyazit University , Ankara , Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Erel
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004220:Disulfides / Q000097:blood*; D017889:Exfoliation Syndrome / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Disulfide; oxidative stress; pseudoexfoliation syndrome; thiol