title: Prognostic values of Ki-67 in neoadjuvant setting for breast cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To assess the prognostic values of Ki-67 in neoadjuvant setting for breast cancer patients.
  
  
  METHODS
  PubMed and EMBASE were searched. Revman software was used to conduct random-effect model meta-analysis.
  
  
  RESULTS
  49 studies (14,076 patients) were included. High Ki-67 before and after neoadjuvant chemotherapy were associated with worse overall survival (OS; before: hazard ratio [HR]: 2.29; 95% CI: 1.42-3.69; after: HR: 2.24; 95% CI: 1.82-2.75) and disease-free survival (DFS; before: HR: 1.54; 95% CI: 1.23-1.95; after: HR: 2.08; 95% CI: 1.83-2.37). Low/no reduction or increase might be associated with worse DFS (HR: 2.13; 95% CI: 1.51-3.02) and OS.
  
  
  CONCLUSIONS
  Ki-67 before and after neoadjuvant chemotherapy, as well as the change could predict the prognosis for breast cancer patients.
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Han
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, Xijing Hospital, Four Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Tian
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Qian
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Qiongyan
authors.initials: Q
authors.lastname: Zou
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yi
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Enxiang
authors.initials: E
authors.lastname: Zhou
authors.affiliation: Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Kehu
authors.initials: K
authors.lastname: Yang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D020360:Neoadjuvant Therapy; D011379:Prognosis; D017594:Publication Bias; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen
keywords: Ki-67; disease-free survival; neoadjuvant chemotherapy; overall survival