title: Disseminated adenovirus infection causing severe ARDS.
abstract: A previously healthy young man with a rare genetic condition presented with severe acute respiratory distress syndrome secondary to pneumonia with septic shock. He did not improve with conventional therapy for his known causal organism thus prompting further workup. He was found to be profoundly immunosuppressed raising our suspicion for atypical organisms. A bronchoalveolar lavage sample was positive via PCR for adenovirus which we suspect exacerbated a pre-existing bacterial pneumonia and led to a severe and non-responsive respiratory failure. His serum adenovirus load was markedly elevated. Treatment was started once the diagnosis of disseminated adenovirus infection was made; however, at that time patient was suffering from refractory hypoxaemia, respiratory acidosis, right heart failure and septic shock. Despite maximal supportive measures our patient ultimately expired over the course of 6 days.
authors.affiliation: Department of Pulmonary, Critical Care, and Sleep, Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Campbell
authors.affiliation: Department of Pulmonary, Critical Care, and Sleep, Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Kynyk
authors.affiliation: Department of Infectious Diseases, Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Davis
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D025063:Chromosome Disorders / Q000150:complications; D002896:Chromosomes, Human, Pair 6; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000175:diagnosis*; D002658:Developmental Disabilities / Q000150:complications; D004452:Echocardiography; D006192:Haemophilus Infections / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D011024:Pneumonia, Viral / Q000150:complications / Q000000981:diagnostic imaging*; D013902:Radiography, Thoracic; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000209:etiology; D014057:Tomography, X-Ray Computed