title: Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG.
abstract: There is a lack of evidence for treatment of pediatric multiple sclerosis (PedMS). Treatment using azathioprine for PedMS has not been reported. A 10-year-old boy with multiple sclerosis who was seropositive for antibodies against myelin oligodendrocyte glycoprotein (MOG)-IgG was treated with azathioprine plus oral methylprednisolone. The patient showed clinical and magnetic resonance imaging stability, with MOG-IgG seroconversion. There were no major side effects over a 5-year period. Azathioprine may be a treatment option, particularly in poor medical resource areas, for pediatric patients with multiple sclerosis who are seropositive for MOG-IgG.
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Neurology, Zhaoqing No. 2 People's Hospital, Guangdong, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Lu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Australia; Institute of Immunology and Infectious Diseases, Murdoch University, Australia.
authors.forename: Allan
authors.initials: A
authors.lastname: Kermode
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: qw9406@gmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
mesh_terms: D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001379:Azathioprine / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000097:blood* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D063308:Myelin-Oligodendrocyte Glycoprotein; D001379:Azathioprine
keywords: Azathioprine; MOG-IgG; Multiple sclerosis; Pediatric