title: Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial.
abstract: Central precocious puberty (CPP) without organic abnormality is called idiopathic CPP (ICPP). The objective of this trial was to evaluate the effects of pomegranate extract in supplementing gonadotropin-releasing hormone (GnRH) analog therapy on ICPP-affected girls in the Chinese population. 286 girls, diagnosed with ICPP were initially enrolled into this trial, and among them 225 eligible patients were randomized to receive a combinational GnRH analog treatment supplemented with either a placebo or pomegranate extract on a daily basis for a period of 3 months. Their demographics, secondary sexual characteristics and hormone profiles were analyzed at baseline and end of trial. After 3 months of treatment, demographic profiles including bone age, growth velocity and height standard deviation score for bone age, and secondary sexual characteristics including uterus and ovary volume, as well as serum hormone profiles including estradiol, peak luteinizing hormone and insulin-like growth factor 1 were all significantly improved in girls receiving a combinational treatment of both GnRH analog and pomegranate extract. Daily consumption of pomegranate extract was able to supplement and improve the treatment outcomes of the GnRH analog therapy for ICPP in Chinese girls.
authors.affiliation: The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. tangjiulai8888@126.com and The Second People's Hospital of Hefei, Hefei 230011, China.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. tangjiulai8888@126.com.
authors.forename: Jiulai
authors.identifier: http://orcid.org/0000-0001-6897-1637
authors.initials: J
authors.lastname: Tang
mesh_terms: D015519:Bone Density; D002648:Child; D002681:China; D019587:Dietary Supplements / Q000032:analysis; D004311:Double-Blind Method; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D029561:Lythraceae / Q000737:chemistry*; D009929:Organ Size; D010936:Plant Extracts / Q000008:administration & dosage*; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D014599:Uterus / Q000254:growth & development / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone