title: A systematic review and meta-analysis of the seroprevalence of Toxoplasma gondii in cats in mainland China.
abstract: Toxoplasmosis is caused by Toxoplasma gondii which can infect all warm-blooded animals. As the most common feline definitive host, cats play a vital role in the transmission of T. gondii. However, national estimates of the seroprevalence of T. gondii in cats in mainland China are lacking, and therefore a systematic review and meta-analysis were performed to provide insight into national environmental transmission levels and potential transmission to humans.
  
  
  
  Studies published up until July 1, 2016, on T. gondii seroprevalence in cats within mainland China were searched for in CNKI, WanFang, CBM, PubMed, Embase and through the reference lists of resulting articles. The seroprevalence with its 95% confidence interval (CI) for each individual study was presented, and then point estimates and their 95% confidence intervals (CIs) of pooled seroprevalence were calculated. Subgroup analyses were performed according to potential risk factors.
  
  
  
  A total of 38 eligible studies, published between 1995 to 2016, covering fifteen provinces and municipalities, and involving 7,285 cats, were included. The seroprevalence in cats per study ranged from 3.9 to 79.4% with a median of 20.3%. As substantial heterogeneity existed among studies, a random-effects model was used to estimate the pooled seroprevalence. The value of the point estimate seroprevalence was 24.5% (95% CI: 20.1-29.0). Seroprevalence in stray cats was significantly higher than in pet cats (OR = 3.00, 95% CI: 1.60-5.64). The seroprevalence increased significantly with cat age (P = 0.018) with 17.4% (95% CI: 7.6-27.2) in the group of ≤ 1 year old, 19.5% (95% CI: 12.7-26.3) in the group of ≤ 3 year-old and 31.6% (95% CI: 22.9-40.3) in the group of > 3 year-old.
  
  
  
  The seroprevalence of T. gondii in cats in mainland China was moderate and was associated with cat ownership and age. Due to the increasing prevalence of pet cats in China and the intimate relationship between these cats and humans, this might present a significant exposure risk, particularly for China's large susceptible population. Therefore, further research is needed into the links between cat ownership and human T. gondii infection and how to reduce T. gondii exposure in humans via cat contacts and the environmental contamination with T. gondii oocysts by cats.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Soochow University, Suzhou, 215123, China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Soochow University, Suzhou, 215123, China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Yu-Meng
authors.initials: YM
authors.lastname: Gao
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Soochow University, Suzhou, 215123, China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Institute of Biodiversity, Animal Health and Comparative Medicine and Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, GL12 8QQ, UK.|Department of Infectious Disease Epidemiology, Imperial College London, London, W2 1PG, UK.
authors.forename: Poppy H L
authors.initials: PH
authors.lastname: Lamberton
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Soochow University, Suzhou, 215123, China. Ludabing@suda.edu.cn.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, 215123, People's Republic of China. Ludabing@suda.edu.cn.
authors.forename: Da-Bing
authors.initials: DB
authors.lastname: Lu
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D002371:Cat Diseases / Q000453:epidemiology*; D002415:Cats; D002681:China / Q000453:epidemiology; D018562:Disease Transmission, Infectious; D006801:Humans; D018570:Risk Assessment; D016036:Seroepidemiologic Studies; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000453:epidemiology*; D015047:Zoonoses / Q000635:transmission
chemical_list: D000913:Antibodies, Protozoan
keywords: Cats; Mainland china; Meta-analysis; Seroprevalence; Toxoplasma gondii