title: Initial subjective reward to alcohol in Sprague-Dawley rats.
abstract: Initial subjective response to the rewarding properties of alcohol predicts voluntary consumption and the risk for alcohol use disorders. We assessed the initial subjective reward to alcohol in rats using a single exposure conditioned place preference (SE-CPP) paradigm. Sprague-Dawley rats demonstrate preference for a context paired with a single systemic injection of ethanol (1.0 g/kg, delivered intraperitoneally). However, expression of SE-CPP in males depended on pairing ethanol with the first exposure of two (ethanol; saline) to the conditioning apparatus and procedures, while conditioning day did not appreciably affect SE-CPP in females, consistent with the view that females experience heightened addiction vulnerability. This model offers researchers a high throughput assay for investigating factors that influence alcohol reward and may point the way toward more effective prevention and treatment efforts.
authors.affiliation: Department of Psychology, Graduate Program at Bucknell University, One Dent Drive, Lewisburg, PA 17837, USA. Electronic address: tbn004@bucknell.edu.
authors.forename: Todd B
authors.initials: TB
authors.lastname: Nentwig
authors.affiliation: Department of Psychology, Neuroscience Program at Bucknell University, One Dent Drive, Lewisburg, PA 17837, USA.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Myers
authors.affiliation: Department of Psychology, Neuroscience Program at Bucknell University, One Dent Drive, Lewisburg, PA 17837, USA. Electronic address: j.grisel@bucknell.edu.
authors.forename: Judith E
authors.initials: JE
authors.lastname: Grisel
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward
chemical_list: D000431:Ethanol
keywords: Alcohol use disorder; Conditioned place preference; Ethanol; Novelty; Sex differences; Susceptibility