title: Shared abnormality of white matter integrity in schizophrenia and bipolar disorder: A comparative voxel-based meta-analysis.
abstract: Patients with schizophrenia and bipolar disorder (BD) shared a significant overlap in genetic susceptibility, pharmacological treatment responses, neuropsychological deficits, and epidemiological features. However, it remains unknown whether these clinical overlaps are mediated by shared or disorder-specific abnormalities of white matter integrity. In this voxel-based meta-analytic comparison of whole-brain white matter integrity, we aimed to identify the shared or disorder-specific structural abnormalities between schizophrenia and BD. A comprehensive literature search was conducted up to February 2016 to identify studies that compared between patients and healthy controls (HC) by using whole-brain diffusion approach (schizophrenia: 24 datasets with 754 patients vs. 775 HC; BD: 23 datasets with 705 patients vs. 679 HC). Voxel-wise meta-analyses were conducted and restricted to unified template using seed-based d-Mapping. Abnormal white matter integrity was calculated within each condition and a direct comparison of effect size was performed of alterations between two conditions. Two regions with significant reductions of fractional anisotropy (FA) characterized abnormal water diffusion in both disorders: the genu of the corpus callosum (CC) and posterior cingulum fibers. There was no significant difference found between the two disorders. Our results highlighted shared impairments of FA at genu of the CC and left posterior cingulum fibers, which suggests that, phenotypic overlap between schizophrenia and BD could be related to common brain circuit dysfunction.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: debo.dong@gmail.com.
authors.forename: Debo
authors.initials: D
authors.lastname: Dong
authors.affiliation: Faculty of Psychological and Educational Sciences, Department of Experimental and Applied Psychology, Research Group of Biological Psychology, Vrije Universiteit Brussel, Brussels 1040, Belgium; Faculty of Psychology and Educational Sciences, Department of Data Analysis, Ghent University, Henri Dunantlaan 2, Ghent B-9000, Belgium. Electronic address: wang.yulin@vub.ac.be.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: XuebinChang@163.com.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Chang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: 414253929@qq.com.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: bklugah@gmail.com.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Klugah-Brown
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: chengluo@uestc.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: dyao@uestc.edu.cn.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
mesh_terms: D016880:Anisotropy; D001714:Bipolar Disorder / Q000150:complications* / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D056784:Leukoencephalopathies / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D012559:Schizophrenia / Q000150:complications* / Q000000981:diagnostic imaging
keywords: Bipolar; Diffusion tensor imaging; Fractional anisotropy; Schizophrenia; Structural connectivity; White matter