title: Expression and clinical significance of Apollon in renal carcinoma.
abstract: Apollon, namely baculoviral inhibitor of apoptosis proteins (IAP) repeat containing 6, is an unusually large member of the IAP family, and may be important in oncogenesis. The aim of the present study was to assess the association between renal carcinoma (RC) and Apollon expression, and to highlight the link between Apollon expression and the occurrence, development and prognosis of RC. Apollon expression was detected by immunohistochemistry, western blotting and reverse transcription-quantitative polymerase chain reaction in RC tissues, adjacent non-cancerous tissues and paired normal tissues, respectively, in order to analyze the association between Apollon expression and clinicopathological features of RC. Kaplan-Meier survival estimate was used to assess the prognostic significance. It was observed that Apollon expression was higher in carcinoma tissues than in adjacent non-cancerous tissues and normal control tissues at the protein and messenger RNA level (P<0.001). There was a significant difference in T-stage (P=0.006), nodal involvement (P=0.007) and tumor-node-metastasis-stage (P=0.035) in patients categorized according to different Apollon expression levels. A prognostic significance of Apollon was also identified by the Kaplan-Meier method. The results of the present study indicate that Apollon expression is associated with the biological characteristics of renal cancer, and is potentially a valuable predictor and novel target for RC.
authors.affiliation: Department of Urology, No. 1 People's Hospital, Jining, Shandong 272011, P.R. China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Guo
authors.affiliation: Graduate School of Southern Medical University, Guangzhou, Guangdong 510515, P.R. China; Department of Urology, Traditional Chinese Medicine Hospital of Luogang, Guangzhou, Guangdong 510530, P.R. China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, P.R. China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Urology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 511447, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510630, P.R. China.
authors.forename: Kuang
authors.initials: K
authors.lastname: Lu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510630, P.R. China.
authors.forename: Zexuan
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Urology, No. 1 People's Hospital, Jining, Shandong 272011, P.R. China.
authors.forename: Shiqing
authors.initials: S
authors.lastname: Zhang
keywords: Apollon; IAPs; apoptosis; prognosis; renal carcinoma