title: Treatment of Concomitant OAB and BPH.
abstract: The etiology of men's lower urinary tract storage and voiding symptoms involves a contribution from both detrusor and outlet. As such, treatment of benign prostatic enlargement (BPE) ± benign prostatic obstruction (BPO) with standard alpha-adrenergic blockade and 5-alpha reductase inhibitor therapy may leave a population of men with persistent and bothersome urinary storage symptoms. An abundance of adequately powered, randomized, placebo-controlled trials indicate that the use of antimuscarinics and beta-3 adrenergic agonists, either alone or in combination with standard BPE/BPO therapy, leads to improvement in storage symptoms. At the same time, metrics associated with urinary emptying, such as maximum flow rate, post-void residual urinary volume, and incidence of treatment-associated urinary retention, appear to be stable and not significantly impacted by the addition of antimuscarinics.
authors.affiliation: Department of Urology, Louisiana State University Health - Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Moss
authors.affiliation: Department of Urology, Louisiana State University Health - Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA.
authors.forename: Tameem
authors.initials: T
authors.lastname: Rezan
authors.affiliation: Department of Urology, Louisiana State University Health - Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA.
authors.forename: Umar R
authors.initials: UR
authors.lastname: Karaman
authors.affiliation: Department of Urology, Louisiana State University Health - Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA. agomel@lsuhsc.edu.
authors.forename: Alex
authors.initials: A
authors.lastname: Gomelsky
mesh_terms: D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000209:etiology / Q000628:therapy; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D053201:Urinary Bladder, Overactive / Q000209:etiology / Q000628:therapy*; D016055:Urinary Retention
keywords: Benign prostatic hypertrophy; Lower urinary tract symptoms; Outcomes; Overactive bladder