title: Chronic kidney disease promotes chronic inflammation in visceral white adipose tissue.
abstract: White adipose tissue plays an important role in the development of metabolic disturbance, which is a common feature in patients with chronic kidney disease (CKD). The effect of CKD on white adipose tissue remains poorly appreciated. Here, we evaluated the inflammatory potential of visceral white adipose tissue in a rat model of CKD. The results showed that production of proinflammatory cytokines and infiltration of macrophage in the tissue were increased significantly in CKD rats compared with sham rats. Moreover, the primary adipocytes and stromal vascular fraction under the condition of CKD could trigger the inflammatory response in each other. Free fatty acid induced robust inflammatory response in ex vivo peritoneal-derived macrophages from CKD rats, which was associated with reduced activity of silent information regulator T1 (SIRT1). Improvement of SIRT1 activity by an activator could alleviate free fatty acid-induced inflammatory response in the macrophages and inflammation in the white adipose tissue. Moreover, oxidative stress occurred in the tissue and linked with the reduced activity of SIRT1 in macrophages and enhanced release of free fatty acid in the tissue. We thus identified CKD as a risk factor for chronic inflammation in white adipose tissue. These observations might open up new therapeutic strategies for metabolic disturbance in CKD via the modulation of adipose tissue-related pathways.
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China.
authors.forename: Dong Mei
authors.initials: DM
authors.lastname: Xiang
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China.
authors.forename: Xiu Zhen
authors.initials: XZ
authors.lastname: Song
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China.
authors.forename: Zhan Mei
authors.initials: ZM
authors.lastname: Zhou
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China.
authors.forename: Xiao Yan
authors.initials: XY
authors.lastname: Dai
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China.
authors.forename: Xiang Lan
authors.initials: XL
authors.lastname: Huang
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China.
authors.forename: Fan Fan
authors.initials: FF
authors.lastname: Hou
authors.affiliation: Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou, China nfyyskzqg@163.com.
authors.forename: Qiu Gen
authors.initials: QG
authors.lastname: Zhou
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D002450:Cell Communication; D002478:Cells, Cultured; D018920:Coculture Techniques; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism*; D050152:Intra-Abdominal Fat / Q000378:metabolism* / Q000503:physiopathology; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress; D015434:Panniculitis / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D017207:Rats, Sprague-Dawley; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000378:metabolism; D013997:Time Factors
chemical_list: D016207:Cytokines; D005230:Fatty Acids, Nonesterified; D018836:Inflammation Mediators; C488368:Sirt1 protein, rat; D056564:Sirtuin 1
keywords: chronic kidney disease; inflammation; macrophage; white adipose tissue