title: Ultrasound shear wave elastography and liver fibrosis: A Prospective Multicenter Study.
abstract: OBJECTIVE
  To assess the accuracy of shear wave elastography (SWE) alone and in combination with aminotransferase platelet ratio index (APRI) score in the staging of liver fibrosis.
  
  
  METHODS
  A multicenter prospective study was conducted to assess the accuracy of SWE (medians) and APRI to predict biopsy results. The analysis focused on distinguishing the different stages of liver disease, namely, F0 from F1-4, F0-1 from F2-4, F0-2 from F3-4 and F0-3 from F4; F0-F1 from F2-F4 being of primary interest. The area under the receiver operating characteristic (AUROC) curve was computed using logistic regression model. The role of age, gender and steatosis was also assessed.
  
  
  RESULTS
  SWE alone accurately distinguished F0-1 from F2-4 with a high probability. The AUROC using SWE alone was 0.91 compared to 0.78 for using the APRI score alone. The APRI score, when used in conjunction with SWE, did not make a significant contribution to the AUROC. SWE and steatosis were the only significant predictors that differentiated F0-1 from F2-4 with an AUROC of 0.944.
  
  
  CONCLUSIONS
  Our study validates the use of SWE in the diagnosis and staging of liver fibrosis. Furthermore, the probability of a correct diagnosis is significantly enhanced with the addition of steatosis as a prognostic factor.
authors.affiliation: Joyce Anyona Sande, Sudhir Vinayak, Department of Radiology, Aga Khan University Hospital, Nairobi 30270-00100, Kenya.
authors.forename: Joyce Anyona
authors.initials: JA
authors.lastname: Sande
authors.affiliation: Joyce Anyona Sande, Sudhir Vinayak, Department of Radiology, Aga Khan University Hospital, Nairobi 30270-00100, Kenya.
authors.forename: Suleman
authors.initials: S
authors.lastname: Verjee
authors.affiliation: Joyce Anyona Sande, Sudhir Vinayak, Department of Radiology, Aga Khan University Hospital, Nairobi 30270-00100, Kenya.
authors.forename: Sudhir
authors.initials: S
authors.lastname: Vinayak
authors.affiliation: Joyce Anyona Sande, Sudhir Vinayak, Department of Radiology, Aga Khan University Hospital, Nairobi 30270-00100, Kenya.
authors.forename: Farin
authors.initials: F
authors.lastname: Amersi
authors.affiliation: Joyce Anyona Sande, Sudhir Vinayak, Department of Radiology, Aga Khan University Hospital, Nairobi 30270-00100, Kenya.
authors.forename: Munir
authors.initials: M
authors.lastname: Ghesani
keywords: Aminotransferase platelet ration; Liver biopsy; Liver fibrosis; Shear wave elastography