title: Totipotency in the mouse.
abstract: In mammals, the unicellular zygote starts the process of embryogenesis and differentiates into all types of somatic cells, including both fetal and extraembryonic lineages-in a highly organized manner to eventually give rise to an entire multicellular organism comprising more than 200 different tissue types. This feature is referred to as totipotency. Upon fertilization, oocyte maternal factors epigenetically reprogram the genomes of the terminally differentiated oocyte and spermatozoon and turn the zygote into a totipotent cell. Today, we still do not fully understand the molecular properties of totipotency. In this review, we discuss recent findings on the molecular signature and mechanism of transcriptional regulation networks in the totipotent mouse embryo.
authors.affiliation: Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149, Münster, Germany.
authors.forename: Guangming
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149, Münster, Germany.|Department of Histology and Embryology, Harbin Medical University, 194 Xuefu Road, Nangang District, Harbin, 150081, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.affiliation: Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149, Münster, Germany. office@mpi-muenster.mpg.de.|Medical Faculty, University of Münster, Domagkstr. 3, 48149, Münster, Germany. office@mpi-muenster.mpg.de.
authors.forename: Hans R
authors.initials: HR
authors.lastname: Schöler
mesh_terms: D000818:Animals; D000073399:DNA Demethylation; D004622:Embryo, Mammalian / Q000196:embryology / Q000378:metabolism; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D042421:Histone Code; D051379:Mice / Q000196:embryology* / Q000235:genetics*; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D015533:Transcriptional Activation; D015053:Zygote / Q000166:cytology / Q000378:metabolism
chemical_list: D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse
keywords: Totipotency; Transcription factors; Zygote