title: Does MHC Class I Chain-Related Gene A Matter?
abstract: In this issue of Biology of Blood and Marrow Transplantation, Askar et al. evaluate the association of MHC class I chain-related gene A (MICA) polymorphisms with the development of graft-versus host-disease (GVHD) after unrelated donor hematopoietic stem cell transplantation (HCT) [1]. Prior reports have provided conflicting results, leaving the effect of MICA donor-recipient mismatch in HCT unanswered.
authors.affiliation: Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Charlotte, North Carolina. Electronic address: Aleksander.chojecki@carolinashealthcare.org.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Chojecki
mesh_terms: D006086:Graft vs Host Disease / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006648:Histocompatibility; D015395:Histocompatibility Antigens Class I / Q000502:physiology*; D006801:Humans; D011110:Polymorphism, Genetic; D014184:Transplantation, Homologous
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A
keywords: Graft-versus-host disease; MHC class I chain-related gene A polymorphisms; MICA