title: Mesoporous carbon nanoshells for high hydrophobic drug loading, multimodal optical imaging, controlled drug release, and synergistic therapy.
abstract: Loading and controlled release of sufficient hydrophobic drugs to tumor cells has been the bottleneck in chemotherapy for decades. Herein we report the development of a fluorescent and mesoporous carbon nanoshell (FMP-CNS) that exhibits a loading capacity for the hydrophobic drug paclitaxel (PTX) as high as ∼80 wt% and releases the drug in a controllable fashion under NIR irradiation (825 nm) at an intensity of 1.5 W cm-2. The high drug loading is primarily attributed to its mesoporous structure and to the supramolecular π-stacking between FMP-CNSs and PTX molecules. The FMP-CNS also exhibits wavelength-tunable and upconverted fluorescence properties and thus can serve as an optical marker for confocal, two-photon, and near infrared (NIR) fluorescence imaging. Furthermore, our in vitro results indicate that FMP-CNSs demonstrate high therapeutic efficacy through the synergistic effect of combined chemo-photothermal treatment. In vivo studies demonstrate marked suppression of tumor growth in mice bearing rat C6 glioblastoma after administration with a single intratumoral injection of PTX-loaded FMP-CNS.
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, United States.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, United States.
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, United States.
authors.forename: Qingxin
authors.initials: Q
authors.lastname: Mu
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, United States.
authors.forename: Zachary R
authors.initials: ZR
authors.lastname: Stephen
authors.affiliation: Department of Chemistry of The College of Staten Island and The Graduate Center, The City University of New York, Staten Island, New York 10314, United States.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Chemistry of The College of Staten Island and The Graduate Center, The City University of New York, Staten Island, New York 10314, United States.
authors.forename: Shuiqin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, United States.
authors.forename: Miqin
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002244:Carbon; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005909:Glioblastoma / Q000188:drug therapy; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D008819:Mice, Nude; D057145:Nanoshells; D017239:Paclitaxel / Q000008:administration & dosage; D051381:Rats; D023041:Xenograft Model Antitumor Assays
chemical_list: D004337:Drug Carriers; D002244:Carbon; D017239:Paclitaxel