title: Antithrombotic Protective Effects of Arg-Pro-Gly-Pro Peptide during Emotional Stress Provoked by Forced Swimming Test in Rats.
abstract: Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Administration of this peptide in 5 min after swimming test also enhanced anticoagulant, fibrinolytic, and antithrombotic activity of the blood. Therefore, glyproline Arg-Pro-Gly-Pro exerted both preventive and curative effects on the hemostasis system and prevented enhancement of blood coagulation provoked by emotional stress modeled by forced swimming test.
authors.affiliation: B. A. Kudryashov Laboratory of Blood Protective System, Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia. mgrigorjeva@mail.ru.
authors.forename: M E
authors.initials: ME
authors.lastname: Grigor'eva
authors.affiliation: B. A. Kudryashov Laboratory of Blood Protective System, Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Lyapina
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D021461:Animals, Outbred Strains; D000925:Anticoagulants / Q000494:pharmacology*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D013550:Swimming / Q000523:psychology
chemical_list: D000925:Anticoagulants; C572888:Arg-Pro-Gly-Pro; D005343:Fibrinolytic Agents; D009842:Oligopeptides
keywords: anticoagulant activity; fibrinolysis; forced swimming test; glyprolines; stress