title: [The First Russian Consensus on the Multilevel Abobotulinumtoxin A Injections in Spastic Forms of Cerebral Palsy].
abstract: Spasticity treatment is one of the key aspects of the contemporary cerebral palsy (CP) rehabilitation that influences on the effectiveness of other methods. The paper presents the first Russian document that unites the recommendations for the BTA treatment of CP and could be used as the guideline for the multilevel injections. The Russian consensus on the multilevel botulinum toxin A (BTA) treatment of spastic CP is based on the international data and the results of national studies. The authors describe typical CP spasticity patterns in the upper and lower extremities, give recommended intervals for the BTA (Abobotulinum toxin A) dosages for the whole injection procedure and for the separate muscles. The method of dosage calculation for functional segments is also described. Attention is paid to the frequency, optimal intervals between the repeated injections and the whole duration of BTA treatment. The authors discuss effectiveness and safety of BTA, factors that potentially influence the results of the injections, including ultrasound and electromyography control, and indications for the continuation and termination of treatment.
authors.affiliation: Scientific Centre of Children's Health of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Kurenkov
authors.affiliation: Scientific Centre of Children's Health of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Klochkova
authors.affiliation: Center for Restorative Treatment and Rehabilitation 'Nadezhda', Tymen, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Zmanovskaya
authors.affiliation: 'Neyroklinika' LLC, Khabarovsk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Falkovskiy
authors.affiliation: Federal State Budgetary Institution 'The Turner Scientific Research Institute for Children's Orthopedics' under the Ministry of the Health of the Russian Federation, Saint-Petersburg, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Kenis
authors.affiliation: Altai regional mental hospital for children, Regional state budget health facility, Barnaul, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Vladykina
authors.affiliation: State budget institution of higher professional education Saint-Petersburg State Pediatric Medical University under the Ministry of Health of the Russian Federation, Department of surgical diseases of childhood, Saint-Petersburg, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Krasavina
authors.affiliation: SBEI APE Russian Medical Academy of Postgraduate Education MPH, Department of neurology, Moscow, Russia; Group of Companies European Medical Center, Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Nosko
authors.affiliation: Federal State Public Scientific Institution 'Scientific Сentre for Family Health and Human Reproduction Problems', Irkutsk, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Rychkova
authors.affiliation: Scientific Centre of Children's Health of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: Kh M
authors.initials: KM
authors.lastname: Karimova
authors.affiliation: Scientific Centre of Children's Health of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: B I
authors.initials: BI
authors.lastname: Bursagova
authors.affiliation: Scientific Centre of Children's Health of the Ministry of Health of the Russian Federation, Moscow, Russia; Sechenov First Moscow Medical State University, Department of allergology and clinical immunology, Moscow, Russia; Pirogov Russian National Scientific Research Medical University, department of pediatrics #1, Moscow, Russia.
authors.forename: L S
authors.initials: LS
authors.lastname: Namazova-Baranova
authors.affiliation: Scientific Centre of Children's Health of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Mamedyarov
authors.affiliation: Scientific Centre of Children's Health of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Kuzenkova
authors.affiliation: 'Neyroklinika' LLC, Khabarovsk, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Dontzov
authors.affiliation: 'Neyroklinika' LLC, Khabarovsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Ryzhenkov
authors.affiliation: Center for Restorative Treatment and Rehabilitation 'Nadezhda', Tymen, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Butorina
authors.affiliation: Center for Restorative Treatment and Rehabilitation 'Nadezhda', Tymen, Russia.
authors.forename: O L
authors.initials: OL
authors.lastname: Pavlova
authors.affiliation: Center for Restorative Treatment and Rehabilitation 'Nadezhda', Tymen, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Harlamova
authors.affiliation: Center for Restorative Treatment and Rehabilitation 'Nadezhda', Tymen, Russia.
authors.forename: D M
authors.initials: DM
authors.lastname: Dankov
authors.affiliation: Tyumen State Medical University, Department of neurology, Tyumen, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Levitina
authors.affiliation: The Federal State-Financed Institution 'Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics of the RF Ministry of Health', Kurgan, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Popkov
authors.affiliation: The Federal State-Financed Institution 'Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics of the RF Ministry of Health', Kurgan, Russia.
authors.forename: S O
authors.initials: SO
authors.lastname: Ryabykh
authors.affiliation: The Federal State-Financed Institution 'Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics of the RF Ministry of Health', Kurgan, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Medvedeva
authors.affiliation: Kurgan Regional Children Hospital Named after Red Cross, Kurgan, Russia.
authors.forename: E B
authors.initials: EB
authors.lastname: Gubina
authors.affiliation: Regional Child Hospital, Stavropol, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Agranovich
authors.affiliation: Federal State Budgetary Institution 'The Turner Scientific Research Institute for Children's Orthopedics' under the Ministry of the Health of the Russian Federation, Saint-Petersburg, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Kiseleva
authors.affiliation: State budget institution of higher professional education Saint-Petersburg State Pediatric Medical University under the Ministry of Health of the Russian Federation, Department of surgical diseases of childhood, Saint-Petersburg, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Vasileva
authors.affiliation: SBEI APE Russian Medical Academy of Postgraduate Education MPH, Department of neurology, Moscow, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Zykov
authors.affiliation: Federal State Public Scientific Institution 'Scientific Сentre for Family Health and Human Reproduction Problems', Irkutsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Mihnovich
authors.affiliation: Federal State Public Scientific Institution 'Scientific Сentre for Family Health and Human Reproduction Problems', Irkutsk, Russia.
authors.forename: Т А
authors.initials: ТА
authors.lastname: Belogorova
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000150:complications / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007802:Language; D035002:Lower Extremity; D008297:Male; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D012426:Russia; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA