title: Contractility of Right Ventricular Myocardium in Male and Female Rats during Physiological and Pathological Hypertrophy.
abstract: Sex differences in the morphogenesis and adaptation of the mechanisms controlling myocardium contractility during physiological and pathological hypertrophy of the right ventricle were demonstrated in mature rats. The study revealed sex-dependent effects of physiological and pathological cardiac hypertrophy on the coefficient of variation of the cardiomyocyte diameter, length-dependent control of the contractile force, and the maximum velocity of isotonic shortening.
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: Yu L
authors.initials: YL
authors.lastname: Protsenko
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Balakin
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Kuznetsov
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.|B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kursanov
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia. lisin.ruslan@gmail.com.
authors.forename: R V
authors.initials: RV
authors.lastname: Lisin
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.|B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Mukhlynina
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.|B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Lookin
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced / Q000503:physiopathology; D048429:Cell Size; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D007537:Isometric Contraction / Q000187:drug effects / Q000502:physiology*; D007551:Isotonic Contraction / Q000187:drug effects / Q000502:physiology*; D008297:Male; D016686:Monocrotaline / Q000633:toxicity; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013550:Swimming
chemical_list: D016686:Monocrotaline
keywords: isometric contraction; isotonic contraction; pathological cardiac hypertrophy; physiological cardiac hypertrophy; rat myocardium