title: Design, synthesis and pharmacological analysis of 5-[4'-(substituted-methyl)[1,1'-biphenyl]-2-yl]-1H-tetrazoles.
abstract: In the present paper 5-[4'-({4-[(4-aryloxy)methyl]-1H-1,2,3-triazol-1-yl}methyl)[1,1'-biphenyl]-2-yl]-1H-tetrazoles (5a-g) and [2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-substituted-1-carbodithioates (11h-q) have been designed and synthesized. These compounds were subjected to docking (against AT1receptor protein enzyme in complex with Lisinopril), in vitro angiotensin converting enzyme inhibition, anti-proliferative, anti-inflammatory screening (through egg albumin denaturation inhibition and red blood cell membrane stabilization assay) and finally anti-fungal activity analyses. Some of the compounds have shown significant pharmacological properties.
authors.affiliation: Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka, 580003, India.
authors.forename: Atulkumar
authors.initials: A
authors.lastname: Kamble
authors.affiliation: Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka, 580003, India. kamchem9@gmail.com.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Kamble
authors.affiliation: Dr. Prabhakar Kore Basic Science Research Center, KLE University, Belagavi, Karnataka, 590010, India.
authors.forename: Suneel
authors.initials: S
authors.lastname: Dodamani
authors.affiliation: Dr. Prabhakar Kore Basic Science Research Center, KLE University, Belagavi, Karnataka, 590010, India.|KLE University's College of Pharmacy, Belagavi, Karnataka, 590010, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Jalalpure
authors.affiliation: Dr. Prabhakar Kore Basic Science Research Center, KLE University, Belagavi, Karnataka, 590010, India.|KLE University's College of Pharmacy, Belagavi, Karnataka, 590010, India.
authors.forename: Vijaykumar
authors.initials: V
authors.lastname: Rasal
authors.affiliation: Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka, 580003, India.
authors.forename: Mahadev
authors.initials: M
authors.lastname: Kumbar
authors.affiliation: Soniya Education Trust's College of Pharmacy, Sangolli Rayanna Nagar, Dharwad, Karnataka, 580002, India.
authors.forename: Shrinivas
authors.initials: S
authors.lastname: Joshi
authors.affiliation: Soniya Education Trust's College of Pharmacy, Sangolli Rayanna Nagar, Dharwad, Karnataka, 580002, India.
authors.forename: Sheshagiri
authors.initials: S
authors.lastname: Dixit
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D044140:Receptor, Angiotensin, Type 1 / Q000819:agonists; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D044140:Receptor, Angiotensin, Type 1; D013777:Tetrazoles; C045574:1H-tetrazole
keywords: ACE inhibition; Anti-inflammatory activity; Anti-proliferative activity; Antifungal activity; Biphenyl; DTC; Tetrazole; Triazole