title: Mechanochemical functionalization of disulfide linked hydrogels.
abstract: Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.
authors.affiliation: Department of Materials Science and Engineering and Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Junmin
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Meredith N
authors.initials: MN
authors.lastname: Silberstein
authors.affiliation: Department of Materials Science and Engineering and Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Amr A
authors.initials: AA
authors.lastname: Abdeen
authors.affiliation: Department of Aerospace Engineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Materials Science and Engineering and Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Kristopher A
authors.initials: KA
authors.lastname: Kilian