title: Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women.
abstract: Few studies have assessed the association of sedentary time with leukocyte telomere length (LTL). In a cross-sectional study conducted in 2012-2013, we examined associations of accelerometer-measured and self-reported sedentary time with LTL in a sample of 1,481 older white and African-American women from the Women's Health Initiative and determined whether associations varied by level of moderate- to vigorous-intensity physical activity (MVPA). The association between sedentary time and LTL was evaluated using multiple linear regression models. Women were aged 79.2 (standard deviation, 6.7) years, on average. Self-reported sedentary time was not associated with LTL. In a model adjusting for demographic characteristics, lifestyle behaviors, and health-related factors, among women at or below the median level of accelerometer-measured MVPA, those in the highest quartile of accelerometer-measured sedentary time had significantly shorter LTL than those in the lowest quartile, with an average difference of 170 base pairs (95% confidence interval: 4, 340). Accelerometer-measured sedentary time was not associated with LTL in women above the median level of MVPA. Findings suggest that, on the basis of accelerometer measurements, higher sedentary time may be associated with shorter LTL among less physically active women.
authors.forename: Aladdin H
authors.initials: AH
authors.lastname: Shadyab
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Macera
authors.forename: Richard A
authors.initials: RA
authors.lastname: Shaffer
authors.forename: Sonia
authors.initials: S
authors.lastname: Jain
authors.forename: Linda C
authors.initials: LC
authors.lastname: Gallo
authors.forename: Michael J
authors.initials: MJ
authors.lastname: LaMonte
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Reiner
authors.forename: Charles
authors.initials: C
authors.lastname: Kooperberg
authors.forename: Cara L
authors.initials: CL
authors.lastname: Carty
authors.forename: Chongzhi
authors.initials: C
authors.lastname: Di
authors.forename: Todd M
authors.initials: TM
authors.lastname: Manini
authors.forename: Lifang
authors.initials: L
authors.lastname: Hou
authors.forename: Andrea Z
authors.initials: AZ
authors.lastname: LaCroix
mesh_terms: D061725:Accelerometry; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000648:ultrastructure*; D008875:Middle Aged; D057185:Sedentary Behavior; D057566:Self Report; D016615:Telomere / Q000648:ultrastructure*; D044465:White People
keywords: accelerometry; leukocyte telomere length; moderate- to vigorous-intensity physical activity; sedentary time; telomeres