title: A Case-control Study of Risk Sources for Severe Fever with Thrombocytopenia Syndrome in Hubei Province, China.
abstract: BACKGROUND
  Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease caused by a novel bunyavirus, was discovered in rural areas of Central China in 2009.
  
  
  METHODS
  A case-control study based on hospital data was applied to detect the potential risk sources for SFTS in SFTS-endemic counties in Hubei Province. Cases were defined as hospitalized SFTSV confirmed patients. Controls were randomly selected from non-SFTSV patients in the same hospital ward within 2 weeks of inclusion of the cases, and they were matched by age (+/- 5 years) and gender according to 1:2 matching condition.
  
  
  RESULTS
  68 cases and 136 controls participated in this study. In multivariate analysis, "Contact with cattle tick" was the major risk source (Conditional Logistic Regression OR-MH=8.62, 95% CI=1.79-41.51), outdoor activities and working in weeds or hillside fields could increase risk of cattle tick contact and SFTS infection (Conditional Logistic Regression OR-MH=8.82, 95% CI=1.69-46.05, P value=0.01).
  
  
  CONCLUSIONS
  Our results suggested cattle might be dominant hosts in SFTS-endemic regions in Hubei Province, which provided clues to transmission mechanism of "vectors, host animals, and humans", thus more effectively preventing and controlling the disease.
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Xuesen
authors.initials: X
authors.lastname: Xing
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Xuhua
authors.initials: X
authors.lastname: Guan
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Junqiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Guoming
authors.initials: G
authors.lastname: Li
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Jianbo
authors.initials: J
authors.lastname: Zhan
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Gongping
authors.initials: G
authors.lastname: Liu
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Xingfu
authors.initials: X
authors.lastname: Shen
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Yichang City Center for Disease Control and Prevention, Yichang, China(3).
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Enshi County Center for Disease Control and Prevention, Enshi, China(4).
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China(5).
authors.forename: Fan
authors.initials: F
authors.lastname: Ding
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Sha
authors.initials: S
authors.lastname: Sha
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2).
authors.forename: Man
authors.initials: M
authors.lastname: Liu
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2). Electronic address: xxs29237155@163.com.
authors.forename: Faxian
authors.initials: F
authors.lastname: Zhan
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002044:Bunyaviridae Infections / Q000635:transmission* / Q000821:virology; D016022:Case-Control Studies; D002417:Cattle / Q000821:virology; D002681:China; D021821:Communicable Diseases, Emerging / Q000635:transmission* / Q000821:virology; D005260:Female; D005334:Fever / Q000821:virology*; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D016851:Orthobunyavirus; D012307:Risk Factors; D013921:Thrombocytopenia / Q000209:etiology* / Q000821:virology; D013987:Ticks / Q000821:virology
keywords: case-control; cattle tick; endemic; risk factors; severe fever with thrombocytopenia syndrome; tick exposure