title: Nuclear pore complexes and regulation of gene expression.
abstract: Nuclear pore complexes (NPCs), are large multiprotein channels that penetrate the nuclear envelope connecting the nucleus to the cytoplasm. Accumulating evidence shows that besides their main role in regulating the exchange of molecules between these two compartments, NPCs and their components also play important transport-independent roles, including gene expression regulation, chromatin organization, DNA repair, RNA processing and quality control, and cell cycle control. Here, we will describe the recent findings about the role of these structures in the regulation of gene expression.
authors.affiliation: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program, 10901 N. Torrey Pines Road, La Jolla, 92037 CA, United States.
authors.forename: Marcela
authors.initials: M
authors.lastname: Raices
authors.affiliation: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program, 10901 N. Torrey Pines Road, La Jolla, 92037 CA, United States. Electronic address: mdangelo@sbpdiscovery.org.
authors.forename: Maximiliano A
authors.initials: MA
authors.lastname: D'Angelo
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D015003:Yeasts / Q000166:cytology / Q000235:genetics
chemical_list: D028861:Nuclear Pore Complex Proteins