title: Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor.
abstract: Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.
authors.affiliation: Institute of Organic Chemistry, Technische Universität Bergakademie Freiberg, Leipziger Strasse 29, Freiberg, Sachsen, Germany. tgruber@lincoln.ac.uk.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hanauer
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hopkinson
authors.affiliation: School of Chemical Sciences and Centre for Green Chemical Science, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. i.leung@auckland.ac.nz.
authors.forename: Kamal
authors.initials: K
authors.lastname: Patel
authors.affiliation: School of Chemical Sciences and Centre for Green Chemical Science, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. i.leung@auckland.ac.nz.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemical Sciences and Centre for Green Chemical Science, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. i.leung@auckland.ac.nz.
authors.forename: Danilo
authors.initials: D
authors.lastname: Correddu
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Akane
authors.initials: A
authors.lastname: Kawamura
authors.affiliation: School of Chemical Sciences and Centre for Green Chemical Science, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. i.leung@auckland.ac.nz.
authors.forename: Vijayalekshmi
authors.initials: V
authors.lastname: Sarojini
authors.affiliation: School of Chemical Sciences and Centre for Green Chemical Science, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. i.leung@auckland.ac.nz.
authors.forename: Ivanhoe K H
authors.identifier: http://orcid.org/0000-0003-0633-6771
authors.initials: IK
authors.lastname: Leung
authors.affiliation: Institute of Organic Chemistry, Technische Universität Bergakademie Freiberg, Leipziger Strasse 29, Freiberg, Sachsen, Germany. tgruber@lincoln.ac.uk.
authors.forename: Tobias
authors.identifier: http://orcid.org/0000-0001-5056-8778
authors.initials: T
authors.lastname: Gruber