title: Pulmonary Function and Arterial Stiffness in Chronic Heart Failure.
abstract: Arterial stiffness contributes to heart failure and is decreased by angiotensin receptor blockers (ARBs). This cross-sectional study aimed to assess associations of lung function and ARB with arterial stiffness in patients with chronic heart failure. 354 outpatients (168 males; 186 females; 68.2 ± 7.2 years old) with chronic heart failure were evaluated. Lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1to FVC ratio (FEV1/FVC), were assessed. The cardio-ankle vascular index (CAVI) was used to estimate arterial stiffness. Unadjusted correlation analyses revealed a positive association of CAVI with ARB but not ACEI, and a negative correlation with FEV1(r= -0.2987,p< 0.0001). Multiple stepwise regression analyses showed that ARB and FEV1 (p< 0.0001) were independent predicting factors for CAVI. These findings suggest that reduced pulmonary function is associated with increased CAVI. Pulmonary function protection could be used to improve the prognosis in heart failure, but additional studies are necessary.
authors.affiliation: Intensive Care Unit and Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China.
authors.forename: Li
authors.identifier: 0000-0001-6491-5339
authors.initials: L
authors.lastname: Li
authors.affiliation: Intensive Care Unit, Zhejiang Provincial People's Hospital, 158 Shangtang Road, Hangzhou 310014, China.
authors.forename: Bangchuan
authors.initials: B
authors.lastname: Hu
authors.affiliation: Intensive Care Unit and Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China.
authors.forename: Shijin
authors.initials: S
authors.lastname: Gong
authors.affiliation: Intensive Care Unit and Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Intensive Care Unit and Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China.
authors.forename: Haiwen
authors.initials: H
authors.lastname: Dai
authors.affiliation: Intensive Care Unit and Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China.
authors.forename: Jing
authors.identifier: 0000-0002-3587-1047
authors.initials: J
authors.lastname: Yan
mesh_terms: D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000008:administration & dosage*; D002908:Chronic Disease / Q000188:drug therapy; D004452:Echocardiography; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D059289:Vascular Stiffness / Q000187:drug effects*; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D057911:Angiotensin Receptor Antagonists