title: Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers.
abstract: Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in gynaecological ﻿and genito-urinary cancer including endometrial, cervical, renal, bladder and prostate cancers.Literature search was performed by Pubmed and Scopus, using the words "intraoperative radiotherapy/IORT", "gynaecological cancer", "uterine/endometrial cancer", "cervical/cervix cancer", "renal/kidney cancer", "bladder cancer" and "prostate cancer". Forty-seven articles were selected from the search databases, analyzed and briefly described.Literature data show that IORT has been used to optimize local control rate in genito-urinary tumours mainly in retrospective studies. The results suggest that IORT could be advantageous in the setting of locally advanced and recurrent disease although further prospective trials are needed to confirm this findings.
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli, 17-28100, Novara, Italy. marco.krengli@med.uniupo.it.|Department of Radiotherapy, University Hospital Maggiore della Carità, Novara, Italy. marco.krengli@med.uniupo.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Krengli
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli, 17-28100, Novara, Italy.|Department of Radiotherapy, University Hospital Maggiore della Carità, Novara, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Pisani
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli, 17-28100, Novara, Italy.|Department of Radiotherapy, University Hospital Maggiore della Carità, Novara, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Deantonio
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli, 17-28100, Novara, Italy.|Department of Obstetrics and Gynecology, University Hospital Maggiore della Carità, Novara, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Surico
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli, 17-28100, Novara, Italy.|Department of Urology, University Hospital Maggiore della Carità, Novara, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Volpe
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli, 17-28100, Novara, Italy.|Department of Obstetrics and Gynecology, University Hospital Maggiore della Carità, Novara, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Surico
authors.affiliation: Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli, 17-28100, Novara, Italy.|Department of Urology, University Hospital Maggiore della Carità, Novara, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Terrone
mesh_terms: D016889:Endometrial Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D012004:Rectal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy* / Q000601:surgery
keywords: Bladder cancer; Cervical cancer; Endometrial cancer; Intraoperative radiotherapy; Prostate cancer; Renal cancer