title: Association of serum uric acid with high-sensitivity C-reactive protein in postmenopausal women.
abstract: OBJECTIVE
  To explore the independent correlation between serum uric acid and low-grade inflammation (measured by high-sensitivity C-reactive protein, hs-CRP) in postmenopausal women.
  
  
  METHODS
  A total of 378 healthy Iranian postmenopausal women were randomly selected in a population-based study. Circulating hs-CRP levels were measured by highly specific enzyme-linked immunosorbent assay method and an enzymatic calorimetric method was used to measure serum levels of uric acid. Pearson correlation coefficient, multiple linear regression and logistic regression models were used to analyze the association between uric acid and hs-CRP levels.
  
  
  RESULTS
  A statistically significant correlation was seen between serum levels of uric acid and log-transformed circulating hs-CRP (r = 0.25, p < 0.001). After adjustment for age and cardiovascular risk factors (according to NCEP ATP III criteria), circulating hs-CRP levels were significantly associated with serum uric acid levels (β = 0.20, p < 0.001). After adjustment for age and cardiovascular risk factors, hs-CRP levels ≥3 mg/l were significantly associated with higher uric acid levels (odds ratio =1.52, 95% confidence interval 1.18-1.96).
  
  
  CONCLUSIONS
  Higher serum uric acid levels were positively and independently associated with circulating hs-CRP in healthy postmenopausal women.
authors.affiliation: a The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: A
authors.initials: A
authors.lastname: Raeisi
authors.affiliation: a The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: A
authors.initials: A
authors.lastname: Ostovar
authors.affiliation: a The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: K
authors.initials: K
authors.lastname: Vahdat
authors.affiliation: a The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: P
authors.initials: P
authors.lastname: Rezaei
authors.affiliation: a The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: H
authors.initials: H
authors.lastname: Darabi
authors.affiliation: a The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: D
authors.initials: D
authors.lastname: Moshtaghi
authors.affiliation: b The Persian Gulf Marine Biotechnology Research Centre, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: I
authors.initials: I
authors.lastname: Nabipour
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007492:Iran; D016015:Logistic Models; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein
keywords: C-reactive protein; Uric acid; inflammation; postmenopause