title: Higher Expression of ERCC1 May Be Associated with Resistance to Adjuvant Platinum-Based Chemotherapy in Gastric Cancer.
abstract: Potential predictive biomarker(s) to respond to chemotherapy in gastric cancer are unclear. Excision repair cross-complementing 1 (ERCC1), a DNA repair enzyme, is associated with clinical outcomes in gastric cancer. Here, we investigated the expression of ERCC1 in gastric cancer with platinum-based chemotherapy after surgery, and the association between ERCC1 expression and clinical parameters was analyzed. Our data showed that high levels of ERCC1 expression were positively associated with resistance to platinum-based chemotherapy but not with lymph node metastasis and pathological stage. In addition, patients with resistance to platinum-based chemotherapy probably had lymph node metastasis and pathological stage.
authors.affiliation: a Department of Pathology , Wuxi No. 2 People's Hospital, Nanjing Medical University , Wuxi , China.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Wan
authors.affiliation: b Department of General Surgery , Wuxi No. 2 People's Hospital, Nanjing Medical University , Wuxi , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chao
authors.affiliation: c Section of Epidemiology and Biostatistics, School of Population Health , The University of Auckland , Auckland , New Zealand.
authors.forename: Arier C
authors.initials: AC
authors.lastname: Lee
authors.affiliation: d The Hospital of Obstetrics & Gynaecology , Fudan University , Shanghai , China.|e Department of Obstetrics & Gynaecology , The University of Auckland , Auckland , New Zealand.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D017024:Chemotherapy, Adjuvant; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D019008:Drug Resistance, Neoplasm; D004720:Endonucleases / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009944:Organoplatinum Compounds; C071447:ERCC1 protein, human; D004720:Endonucleases
keywords: ERCC1; Gastric cancer; lymph node metastasis; pathological stage; platinum-based chemotherapy