title: Disease burden of hepatitis E in a rural population in China: a community-based survey.
abstract: This study aimed to estimate the disease burden of hepatitis E in a rural region in China. A total of 489 hepatitis E cases were reported according to a community-based survey in an active hepatitis surveillance system between 2008 and 2015, the questionnaire and record-review methods were constructed to evaluate the economic and health burden of hepatitis E virus infections from societal perspectives. All costs were converted to US$ in 2015. The age-standardized cumulative incidence rate was 107·9/100 000, and the median age-standardized annual incidence rate was 16·5/100 000. The median direct, indirect, and intangible cost were $1046·0, $49·1, and $77·3/patient, respectively, and the median economic burden per patient was $1836·5, which accounted for 51·2% of per capita disposable income. Moreover, the median quality-adjusted life year and visual analogue scale score were 0·7 and 70·0/case, respectively. Both economic burden and health burden of inpatients was more serious than that of outpatients (P < 0·001). Disease burden of hepatitis E is heavy on patients, their families, and society. More studies on the disease burden of hepatitis E are necessary to increase social awareness of the disease and confirm reasonable disease-control measures.
authors.affiliation: Dongtai Center for Disease Control and Prevention,Dongtai,Jiangsu Province,China.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Public Health,Xiamen University,Xiamen,China.
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,School of Public Health,Southeast University,Nanjing,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Dongtai Center for Disease Control and Prevention,Dongtai,Jiangsu Province,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Dongtai Center for Disease Control and Prevention,Dongtai,Jiangsu Province,China.
authors.forename: C
authors.initials: C
authors.lastname: Yang
authors.affiliation: Dongtai Center for Disease Control and Prevention,Dongtai,Jiangsu Province,China.
authors.forename: J
authors.initials: J
authors.lastname: Cai
authors.affiliation: Dongtai Center for Disease Control and Prevention,Dongtai,Jiangsu Province,China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Public Health,Xiamen University,Xiamen,China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,School of Public Health,Southeast University,Nanjing,China.
authors.forename: H
authors.initials: H
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D017281:Cost of Illness; D005260:Female; D017048:Health Care Costs; D016751:Hepatitis E / Q000191:economics / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019057:Quality-Adjusted Life Years; D012424:Rural Population; D055815:Young Adult
keywords: Community-based survey; disease burden; hepatitis E