title: Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training.
abstract: BACKGROUND
  It has not been established whether progressive resistance training (PRT) and aerobic training (AT) are feasible and efficient in myasthenia gravis (MG).
  
  
  METHODS
  Fifteen subjects with generalized MG (Myasthenia Gravis Foundation of America (MGFA) clinical classification II-IV) were randomly assigned to 20 training sessions during 8 weeks of either PRT or AT. Feasibility was evaluated based on adherence, drop-out rate, adverse events, and Quantitative Myasthenia Gravis (QMG) score.
  
  
  RESULTS
  Twelve subjects (MGFA II, n = 11; MGFA III, n=1) completed the intervention with a mean adherence of 95 % ± 8. One dropout (PRT) could potentially be related to PRT. Both groups reported adverse events, including bulbar symptoms (n = 2) and increased fatigue (n = 3), but no change in QMG score was observed in either group. The PRT group showed increases in maximal strength and functional capacity.
  
  
  CONCLUSIONS
  Eight weeks of moderate to high intensity AT and PRT were feasible for most patients with mild MG. Maximal strength and functional capacity increased in the PRT group. Muscle Nerve 56: 700-709, 2017.
authors.affiliation: Section for Sport Science, Department of Public Health, Aarhus University, Denmark, Dalgas Avenue 4, 8000, Aarhus C, Denmark.
authors.forename: Martin Amadeus
authors.initials: MA
authors.lastname: Rahbek
authors.affiliation: Section for Sport Science, Department of Public Health, Aarhus University, Denmark, Dalgas Avenue 4, 8000, Aarhus C, Denmark.
authors.forename: Erik Elgaard
authors.initials: EE
authors.lastname: Mikkelsen
authors.affiliation: Section for Sport Science, Department of Public Health, Aarhus University, Denmark, Dalgas Avenue 4, 8000, Aarhus C, Denmark.
authors.forename: Kristian
authors.initials: K
authors.lastname: Overgaard
authors.affiliation: Department of Neurology, Aarhus University Hospital, Noerrebrogade, 44, 8000 Aarhus C, Denmark.
authors.forename: Lotte
authors.initials: L
authors.lastname: Vinge
authors.affiliation: Department of Neurology, Aarhus University Hospital, Noerrebrogade, 44, 8000 Aarhus C, Denmark.
authors.forename: Henning
authors.initials: H
authors.lastname: Andersen
authors.affiliation: Section for Sport Science, Department of Public Health, Aarhus University, Denmark, Dalgas Avenue 4, 8000, Aarhus C, Denmark.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Dalgas
mesh_terms: D000328:Adult; D000368:Aged; D004576:Electromyography / Q000379:methods; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D055070:Resistance Training / Q000379:methods*; D013997:Time Factors
keywords: aerobic training; exercise training; feasibility; myasthenia gravis; neurological disorder; progressive resistance training