title: Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve.
abstract: The incidence of ectopic pregnancy after assisted reproductive technology is increased approximately 2.5-5-fold compared with natural conceptions.Strategies were used to decrease the incidence of ectopic pregnancy, but ectopic pregnancy still occurs. In the present study, women were selected with decreased ovarian reserve (defined as FSH > 10 IU/L) aged 20 to 38 years who underwent IVF-ET between 2009 and 2014. These 2,061 women were age-matched with an equal number of women with normal ovarian reserve (defined as FSH ≤ 10 IU/L). During cycles following fresh embryo transfer, 93 patients were diagnosed with ectopic pregnancy. The incidence of ectopic pregnancy in clinical pregnancies was significantly higher in the decreased ovarian reserve than in the normal ovarian reserve group (5.51% vs. 2.99%). After adjusting for confounding factors, the incidence of ectopic pregnancy was significantly associated with decreased ovarian reserve. Our results showed that decreased ovarian reserve is an independent risk factor for ectopic pregnancy after in vitro fertilization-embryo transfer.
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Lin
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Chi
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lian
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Jiejing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Huang
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Lu
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
mesh_terms: D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D015999:Multivariate Analysis; D065851:Ovarian Reserve; D010331:Paternal Age; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis* / Q000453:epidemiology / Q000208:ethnology; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: IVF; decreased ovarian reserve; ectopic pregnancy