title: Molecular targets of the Warburg effect and inflammatory cytokines in the pathogenesis of pulmonary artery hypertension.
abstract: Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by increased pulmonary arterial pressure and vasoconstriction and structural remolding of pulmonary arterioles. Recent clinical and experimental studies have discovered the relationship between metabolic alterations and the pathogenesis of PAH. The primary metabolic alteration, previously demonstrated in various cancers, is a gradual change in energy generated from complete aerobic cellular respiration to from solely "aerobic glycolysis," termed the "Warburg effect." Understanding the Warburg effect of metabolic dysregulation and its interaction with inflammatory mechanisms in the pathogenesis of PAH has provided a valuable explanation of this disease and has guided formulation of new clinical treatments at the molecular level.
authors.affiliation: Department of Cardiology and Cardiac Catheterization Lab, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: University of Nebraska Medical Center, United States.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Parry
authors.affiliation: Department of Cardiology, Hunan Children's Hospital, Changsha, Hunan Province, China.
authors.forename: Yunbin
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Cardiology and Cardiac Catheterization Lab, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Shenghua
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Cardiology and Cardiac Catheterization Lab, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China. Electronic address: qimingliuxyeyy@126.com.
authors.forename: Qiming
authors.initials: Q
authors.lastname: Liu
mesh_terms: D016207:Cytokines / Q000502:physiology*; D004734:Energy Metabolism; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology*; D007249:Inflammation / Q000503:physiopathology; D058990:Molecular Targeted Therapy / Q000379:methods; D011651:Pulmonary Artery / Q000503:physiopathology
chemical_list: D016207:Cytokines
keywords: Inflammation; Mitochondrial; Pulmonary arterial hypertension (PAH); Therapeutic; Warburg effect