title: New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft.
abstract: In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga,Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound1was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound1showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation.
authors.affiliation: UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. malikhejric@gmail.com.
authors.forename: Liaqat
authors.initials: L
authors.lastname: Ali
authors.affiliation: UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. latifepm78@yahoo.co.uk.
authors.forename: Abdul Latif
authors.initials: AL
authors.lastname: Khan
authors.affiliation: UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. albroumi@unizwa.edu.om.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Al-Broumi
authors.affiliation: UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. rashid@unizwa.edu.om.
authors.forename: Rashid
authors.initials: R
authors.lastname: Al-Harrasi
authors.affiliation: Marine Science and Fisheries Center, Ministry of Agriculture and Fisheries Resources, Muscat-113, Oman. lubna.alkharusi@gmail.com.
authors.forename: Lubna
authors.initials: L
authors.lastname: Al-Kharusi
authors.affiliation: UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. javidhej@unizwa.edu.om.|Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, Nizwa-616, Oman. javidhej@unizwa.edu.om.
authors.forename: Javid
authors.initials: J
authors.lastname: Hussain
authors.affiliation: UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman. aharrasi@unizwa.edu.om.|Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, Nizwa-616, Oman. aharrasi@unizwa.edu.om.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Harrasi
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D000459:Phaeophyceae / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D014315:Triterpenes; D000520:alpha-Glucosidases
keywords: Padina boergesenii; enzyme inhibition; phytochemical investigation; structure elucidation