title: Management for BI-RADS category 3 lesions detected in preoperative breast MR imaging of breast cancer patients.
abstract: OBJECTIVE
  To retrospectively evaluate characteristics of and determine appropriate follow-up recommendations for BI-RADS category 3 lesions detected in preoperative MRI of breast cancer patients.
  
  
  METHODS
  BI-RADS category 3 assessments were identified from the breast MRI database for 5,110 consecutive breast cancer patients who had undergone preoperative MRI and surgery. Patient and lesion characteristics, malignancy rate, and interval between lesion detection and cancer diagnosis were analysed. Histopathological results or imaging at or after 2-year follow-up were used as reference standards.
  
  
  RESULTS
  Of the 626 lesions, morphological features included a single focus in 26.5% (n = 166), multiple foci in 47.1% (n = 295), mass in 21.7% (n = 136) and non-mass enhancement in 4.6% (n = 29). Cancer was found in 0.8% (5/626) at a median interval of 50 months (range, 29-66 months). Malignancy rate according to morphological feature was: 1.8% (3/166) in a single focus, 0.7% (1/136) in mass and 3.4% (1/29) in non-mass enhancement. All detected cancers were stage 0 or IA.
  
  
  CONCLUSIONS
  Annual follow-up might be adequate for BI-RADS category 3 lesions detected at preoperative MRI because of the 0.8% (5/626) malignancy rate, long interval between lesion detection and cancer diagnosis, and early stage of diagnosed cancers.
  
  
  CONCLUSIONS
  • BI-RADS category 3 lesions on preoperative MRI had 0.8% malignancy rate. • All cancer diagnoses from BI-RADS 3 occurred after 24-month follow-up. • Annual follow-up might be adequate for BI-RADS 3 detected on preoperative MRI.
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea.|Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hye Mi
authors.initials: HM
authors.lastname: Gweon
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea. river7774@gmail.com.
authors.forename: Nariya
authors.identifier: http://orcid.org/0000-0003-4290-2777
authors.initials: N
authors.lastname: Cho
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea.
authors.forename: Soo-Yeon
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Radiology, Hanyang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hye Ryoung
authors.initials: HR
authors.lastname: Koo
authors.affiliation: Department of Radiology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
authors.forename: Mirinae
authors.initials: M
authors.lastname: Seo
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Boramae Medical Center, Seoul, Republic of Korea.
authors.forename: Ajung
authors.initials: A
authors.lastname: Chu
authors.affiliation: Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Son
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D003266:Continuity of Patient Care; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies
keywords: Appointments and schedule; Breast cancer; Follow-up studies; Imaging; Magnetic resonance imaging