title: Critical role of calpain in inflammation.
abstract: Calpains are a family of cysteine proteases, implicated in a wide range of cellular calcium-regulated functions. Evidence from previous studies using an inhibitor of calpain indicates that calpain activation is involved in the process of numerous inflammation-associated diseases. As a result of in-depth studies, calpains have been proposed to influence the process of inflammation via a variety of mechanisms. The aim of the present study is to provide an overview of recent reports regarding the role of calpain in the process of inflammation, including regulation of immune cell migration, modulation of the activation of inflammatory mediators, degradation of certain associated proteins and induction of cell apoptosis. Understanding these mechanisms may contribute to the investigation of novel therapeutic targets for inflammation-associated diseases.
authors.affiliation: Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China; Graduate School, Guangzhou Medical University, Guangzhou, Guangdong 510010, P.R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ji
authors.affiliation: Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China; Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Su
authors.affiliation: Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China; Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Liu
keywords: calpain; diabetes; immune cell; inflammation; inflammatory mediator; sepsis