title: [Clotrimazole and ciclopirox olamine respectively in combination with methylprednisolone aceponate as extemporaneous formulations].
abstract: The combination of topical fungicide and glucocorticoids has been proven as a successful therapy of cutaneous mycoses with accompanying inflammatory reactions, particularly when used at an early stage. Various national and international therapeutic guidelines recommend this practice. In this context, two individually manufactured formulations have been developed and tested for stability: the combination of methylprednisolone aceponate-a topical glucocorticoid with the therapeutic index of 2.0-with clotrimazole and with ciclopirox olamine, respectively. This has been conducted in compliance with the requirements for quality controlled extemporaneous formulations and the legal framework of the German Pharmacy Working Regulations (Apothekenbetriebsordnung). There are now two formulations for clinical use that are microbiologically, physically, and chemically stable, which combine methylprednisolone aceponate-a glucocorticoid with a good risk-benefit ratio-with the broad-spectrum fungicides clotrimazole and, for the first time, ciclopirox olamine.
authors.affiliation: Universitätsklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle‑Wit﻿tenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland. johannes.wohlrab@medizin.uni-halle.de.|An-Institut für angewandte Dermatopharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland. johannes.wohlrab@medizin.uni-halle.de.
authors.forename: J
authors.initials: J
authors.lastname: Wohlrab
authors.affiliation: An-Institut für angewandte Dermatopharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.
authors.forename: R H H
authors.initials: RH
authors.lastname: Neubert
authors.affiliation: An-Institut für angewandte Dermatopharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Sommer
authors.affiliation: An-Institut für angewandte Dermatopharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Michael
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage*; D000077768:Ciclopirox; D003022:Clotrimazole / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage; D003881:Dermatomycoses / Q000188:drug therapy* / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D019317:Evidence-Based Medicine; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011728:Pyridones / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D003879:Dermatologic Agents; D004338:Drug Combinations; D011728:Pyridones; D000077768:Ciclopirox; C078007:methylprednisolone aceponate; D003022:Clotrimazole; D008775:Methylprednisolone
keywords: Antifungal agents; Glucocorticoids; Inflammation; Mycoses; Safety