title: Growing OXA-23 type strains among carbapenem-resistantAcinetobacter baumanniiand tigecycline as an alternate combination therapy.
abstract: OBJECTIVE
  The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains.
  
  
  METHODS
  Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted. Presence of blaOXA-23, blaOXA-48, blaOXA-58, and NDM-1 was investigated by PCR.
  
  
  RESULTS
  In total, 44 carbapenem-resistant A. baumannii strains were detected. In addition, 57% (25/44) showed resistance to netilmicin and 2% (1/43) to tigecycline. All of the strains were susceptible to colistin. blaOXA-58 was found only in one (2%) strain while blaOXA-23 was found in 14 (32%) strains. All strains were negative for blaOXA-48 and NDM-1.
  
  
  CONCLUSIONS
  blaOXA-23 was the main resistance pattern in carbapenem-resistant A. baumannii strains. blaOXA-58 was present only in one strain and no blaOXA-48 was found. Tigecycline susceptibility is high and it can be a treatment option for a possible combination therapy of carbapenem-resistant A. baumannii, especially for those for whom colistin is contraindicated because of its toxicity.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Polatlı Duatepe State Hospital, Ankara, Turkey.
authors.forename: Şerife
authors.initials: Ş
authors.lastname: Altun
authors.affiliation: Department of Infectious Diseases & Clinical Microbiology, Ankara Atatürk Training and Research Hospital, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Koçak Tufan
authors.affiliation: Center for Stem Cell Research and Development, Hacettepe University, Ankara, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Altun
authors.affiliation: Department of Microbiology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Önde
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Sami
authors.initials: S
authors.lastname: Kınıklı
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Ali Pekcan
authors.initials: AP
authors.lastname: Demiröz
mesh_terms: D000151:Acinetobacter Infections; D040981:Acinetobacter baumannii; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D024901:Drug Resistance, Multiple, Bacterial; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives; D000078304:Tigecycline; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000078304:Tigecycline; D001618:beta-Lactamases; D008911:Minocycline
keywords: Acinetobacter; OXA; beta-lactamases; carbapenemase; drug resistance