title: The role of T-box genes in the tumorigenesis and progression of cancer.
abstract: The T-box (TBX) genes are part of an evolutionarily conserved family of transcription factors involved in organ development. They serve key roles in a number of molecular mechanisms, including proliferation, cell fate and organ identity. In addition, previous studies suggest that TBX genes have essential functions in the tumorigenesis and progression of various types of cancer. For example, TBX proteins served significant roles in carcinogenesis, proliferation and differentiation, senescence and apoptosis, invasion and migration, mesenchymal-epithelial and epithelial-mesenchymal transition, oncogenic signaling pathways and drug sensitivity. However, the exact mechanisms by which TBX genes carry out these functions have not yet been fully elucidated. The present review focuses on the role of TBX genes in cancer, with the aim of further clarifying their function. As altered levels of TBX proteins have detrimental consequences in numerous types of cancer, there is a need for further research into TBX genes, which this review may aid through providing a comprehensive insight into the topic.
authors.affiliation: Bone and Soft Tissue Tumor Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China.
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Chang
authors.affiliation: Bone and Soft Tissue Tumor Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Xing
authors.affiliation: National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China; Epidemiology and Biostatistics Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China.
authors.forename: Fengju
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Diagnostics, Tianjin Medical University, Tianjin 300061, P.R. China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Du
authors.affiliation: Bone and Soft Tissue Tumor Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China.
authors.forename: Guowen
authors.initials: G
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China; Epidemiology and Biostatistics Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Chen
authors.affiliation: Bone and Soft Tissue Tumor Department, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P.R. China.
authors.forename: Jilong
authors.initials: J
authors.lastname: Yang
keywords: T-box genes; cancer; therapy; tumor progression; tumorigenesis