title: Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder.
abstract: We examined progranulin (PGRN) levels in cerebrospinal fluid (CSF) samples during the acute phase in 15 patients with neuromyelitis optica spectrum disorders (NMOSD) and compared the results with those from 17 patients with multiple sclerosis (MS), 30 patients with other inflammatory neurological diseases (OIND), and 20 non-inflammatory controls (NIC). CSF PGRN levels of NMOSD patients were significantly higher than those of MS patients and NICs. These levels correlated with CSF interleukin-6 levels, CSF cell counts, CSF protein levels, improvements in the Expanded Disability Status Scale score, and affected total spinal cord lesion length in the NMOSD patients.
authors.affiliation: Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: kimura1@gifu-u.ac.jp.
authors.forename: Akio
authors.initials: A
authors.lastname: Kimura
authors.affiliation: Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan; Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, Toyoake, Aichi, Japan. Electronic address: takem@gifu-u.ac.jp.
authors.forename: Masao
authors.initials: M
authors.lastname: Takemura
authors.affiliation: Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Toyoake, Aichi, Japan. Electronic address: saito.kuniaki.25r@st.kyoto-u.ac.jp.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Saito
authors.affiliation: R&D and Precision Antibody Divisions, A&G Pharmaceutical Inc, Columbia, MD, USA. Electronic address: gserrero@agpharma.com.
authors.forename: Ginette
authors.initials: G
authors.lastname: Serrero
authors.affiliation: Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: ny1113@gifu-u.ac.jp.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Yoshikura
authors.affiliation: Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: hayashiy@gifu-u.ac.jp.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: tinuzuka@gifu-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Inuzuka
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood; D051401:Aquaporin 4 / Q000276:immunology; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid*; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid; D000077153:Progranulins; D013223:Statistics as Topic
chemical_list: C496030:AQP4 protein, human; D000906:Antibodies; D051401:Aquaporin 4; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D000077153:Progranulins
keywords: Cerebrospinal fluid; Interleukin-6; Microglia; Neuromyelitis optica spectrum disorder; Neuroprotection; Progranulin