title: ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.
abstract: A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function. The aim of this study was to investigate serum ADAMTS-3, -13, -16, and -19 levels in women with habitual abortions compared with those in healthy controls. A total of 86 women were enrolled in this prospective case-control study. ADAMTS-3, -13, -16, and -19 values were recorded and analyzed in association with demographic and clinical parameters. There were no statistically significant differences between the two groups in terms of demographics. No statistically significant differences were observed between the groups with regard to ADAMTS-13 and -19 levels (p>0.05). However, ADAMTS-3 and -16 were significantly higher in the study group than in the control group (p=0.004 and p=0.005, respectively). To estimate habitual abortions using an area under receiver operating characteristic curve analysis, the cutoff values for ADAMTS-3 and -16 were found to be 87.28 ng/mL (sensitivity, 64.44%; specificity 68.29%) and 15.75 ng/mL (sensitivity, 66.67%; specificity 68.29%), respectively. In conclusion, the pregnancy-loss rate seems to be affected by both ADAMTS-3 and -16.
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Meryem Kuru
authors.initials: MK
authors.lastname: Pekcan
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Esma
authors.initials: E
authors.lastname: Sarıkaya
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: aytekintokmak@gmail.com.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.affiliation: Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alışık
authors.affiliation: Department of Biostatistics, Faculty of Medicine Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Afra
authors.initials: A
authors.lastname: Alkan
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Gülnur
authors.initials: G
authors.lastname: Özakşit
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Erel
mesh_terms: D000071096:ADAMTS Proteins / Q000097:blood / Q000235:genetics*; D000071120:ADAMTS13 Protein / Q000097:blood / Q000235:genetics*; D000026:Abortion, Habitual / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D011247:Pregnancy; D011348:Procollagen N-Endopeptidase / Q000097:blood / Q000235:genetics*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D000071096:ADAMTS Proteins; C510098:ADAMTS16 protein, human; C544648:ADAMTS19 protein, human; C434951:ADAMTS3 protein, human; D011348:Procollagen N-Endopeptidase; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human
keywords: ADAMTS proteinases; Embryo implantation; Extracellular matrix; Idiopathic recurrent miscarriage; Pregnancy loss