title: Role of STIM2 in cell function and physiopathology.
abstract: An endoplasmic reticulum (ER)-resident protein that regulates cytosolic and ER free-Ca2+concentration by induction of store-operated calcium entry: that is the original definition of STIM2 and its function. While its activity strongly depends on the amount of calcium stored in the ER, its function goes further, to intracellular signalling and gene expression. Initially under-studied owing to the prominent function of STIM1, STIM2 came to be regarded as vital in mice, gradually emerging as an important player in the nervous system, and cooperating with STIM1 in the immune system. STIM2 has also been proposed as a relevant player in pathological conditions related to ageing, Alzheimer's and Huntington's diseases, autoimmune disorders and cancer. The discovery of additional functions, together with new splicing forms with opposite roles, has clarified existing controversies about STIM2 function in SOCE. With STIM2 being essential for life, but apparently not for development, newly available data demonstrate a complex and still intriguing behaviour that this review summarizes, updating current knowledge of STIM2 function.
authors.affiliation: Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003, Barcelona, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Berna-Erro
authors.affiliation: Department of Physiology (Cell Physiology Research Group), University of Extremadura, 10003, Cáceres, Spain.
authors.forename: Isaac
authors.identifier: 0000-0003-4575-8264
authors.initials: I
authors.lastname: Jardin
authors.affiliation: Department of Physiology (Cell Physiology Research Group), University of Extremadura, 10003, Cáceres, Spain.
authors.forename: Gines M
authors.initials: GM
authors.lastname: Salido
authors.affiliation: Department of Physiology (Cell Physiology Research Group), University of Extremadura, 10003, Cáceres, Spain.
authors.forename: Juan A
authors.identifier: 0000-0002-9749-2325
authors.initials: JA
authors.lastname: Rosado
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism; D000071738:Stromal Interaction Molecule 2 / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D000071738:Stromal Interaction Molecule 2
keywords: STIM2; calcium entry; store-operated calcium entry