title: And the fat lady sings about phosphate and calcium.
abstract: Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity.
authors.affiliation: Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland. Electronic address: Wagnerca@access.uzh.ch.
authors.forename: Carsten A
authors.initials: CA
authors.lastname: Wagner
authors.affiliation: Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.
authors.forename: Pedro H
authors.initials: PH
authors.lastname: Imenez Silva
authors.affiliation: Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.
authors.forename: Isabel
authors.initials: I
authors.lastname: Rubio-Aliaga
mesh_terms: D000273:Adipose Tissue; D002118:Calcium; D002136:Calcium, Dietary; D006706:Homeostasis; D010710:Phosphates
chemical_list: D002136:Calcium, Dietary; D010710:Phosphates; D002118:Calcium