title: Intraepidermal proliferation of Merkel cells within a seborrheic keratosis: Merkel cell carcinoma in situ or Merkel cell hyperplasia?
abstract: Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation or a neoplastic process, namely Merkel cell carcinoma (MCC) in situ. The recent criteria that have been proffered to diagnose MCC in situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells. Most previously reported cases of MCC in situ have occurred within associated epithelial lesion that includes solar (actinic) keratosis and squamous-cell carcinoma in situ. Similarly, Merkel cell hyperplasia has been reported to occur in association with a variety of epithelial lesions as well as on chronically sun-damaged skin. Herein, a case of an intraepidermal proliferation of Merkel cells within a seborrheic keratosis is presented accompanied by a discussion on whether the proliferation represents another case of Merkel cell carcinoma in situ or an incidental hyperplastic process on chronically sun-damaged skin.
authors.affiliation: Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Jeanne
authors.initials: J
authors.lastname: McFalls
authors.affiliation: Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Lauren
authors.identifier: http://orcid.org/0000-0002-8154-4258
authors.initials: L
authors.lastname: Okon
authors.affiliation: Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Sarah
authors.initials: S
authors.lastname: Cannon
authors.affiliation: Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Jason B
authors.initials: JB
authors.lastname: Lee
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D017492:Keratosis, Seborrheic / Q000378:metabolism / Q000473:pathology; D018862:Merkel Cells / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
keywords: Merkel cell; Merkel cell carcinoma in situ; histopathology; hyperplasia; seborrheic keratosis