title: Fe-nitrilotriacetic acid coordination polymer nanowires: an effective sensing platform for fluorescence-enhanced nucleic acid detection.
abstract: The determination of specific nucleic acid sequences is key in identifying disease-causing pathogens and genetic diseases. In this paper we report the utilization of Fe-nitrilotriacetic acid coordination polymer nanowires as an effective nanoquencher for fluorescence-enhanced nucleic acid detection. The detection is fast and the whole process can be completed within 15 min. This nanosensor shows a low detection limit of 0.2 nM with selectivity down to single-base mismatch. This work provides us with an attractive sensing platform for applications.
authors.affiliation: National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, People's Republic of China.
authors.forename: Yunchun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Xuping
authors.initials: X
authors.lastname: Sun
authors.forename: Rongmei
authors.initials: R
authors.lastname: Kong
mesh_terms: D015374:Biosensing Techniques; D002712:Chlorides / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000032:analysis*; D005290:Ferric Compounds / Q000737:chemistry*; D057230:Limit of Detection; D053770:Nanowires / Q000737:chemistry / Q000648:ultrastructure; D009571:Nitrilotriacetic Acid / Q000737:chemistry*; D015345:Oligonucleotide Probes / Q000737:chemistry*; D011108:Polymers; D012996:Solutions; D013050:Spectrometry, Fluorescence
chemical_list: D002712:Chlorides; D056831:Coordination Complexes; D004277:DNA, Single-Stranded; D005290:Ferric Compounds; D015345:Oligonucleotide Probes; D011108:Polymers; D012996:Solutions; D009571:Nitrilotriacetic Acid; C024555:ferric chloride