title: The relationship between angiotensin-converting enzyme (ACE) insertion (I) / deletion (D) polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese.
abstract: OBJECTIVE
  In this study, we set out to investigate the relationship between angiotensin-converting enzyme ( ACE) I/D polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese.
  
  
  METHODS
  A standardized, structured, face-to-face interview was performed to collect demographic information. BMD was measured using dual-energy X-ray absorptiometry (DXA). I/D genotypes of ACE were determined by polymerase chain reaction (PCR) amplification. Serum ACE activity was determined photometrically by a commercially available kinetic kit. Multiple linear regression analysis was used to examine the relationship between ACE I/D polymorphism, serum ACE activity and BMD.
  
  
  RESULTS
  A total of 1567 males and 1760 females were selected for analyzing the relationship between ACE I/D polymorphism and BMD. There was no significant difference in spine BMD, total hip BMD and femur neck BMD among different ACE I/D genotypes both in males and females. A total of 1699 males and 1739 females were selected for analyzing the relationship between serum ACE activity and BMD. There was also no significant difference in spine BMD, total hip BMD and femur neck BMD among different serum ACE activity groups both in males and females.
  
  
  CONCLUSIONS
  There was no relationship between ACE I/D polymorphism, serum ACE activity and BMD in older Chinese.
authors.affiliation: 1 Department of Orthopaedics, The Affiliated Hospital to Nantong University, PR China.|2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Ya-Feng
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: 1 Department of Orthopaedics, The Affiliated Hospital to Nantong University, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: 3 Jiangsu Provincial Key Laboratory of Neural Regeneration, Nantong University, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: 4 Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.affiliation: 5 Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Nelson Ls
authors.initials: NL
authors.lastname: Tang
authors.affiliation: 6 Jockey Club Center for Osteoporosis Care and Control, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Ping-Chong
authors.initials: PC
authors.lastname: Leung
authors.affiliation: 2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Timothy Cy
authors.initials: TC
authors.lastname: Kwok
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; Chinese; I/D polymorphism; bone mineral density; serum ACE activity