title: Safety of remifentanil in transsphenoidal surgery: A single-center analysis of 540 patients.
abstract: Although some studies have examined the efficacy and safety of remifentanil in patients undergoing neurosurgical procedures, none has examined its safety in transsphenoidal operations specifically. In this study, all transsphenoidal operations performed by a single author from 2008 to 2015 were retrospectively reviewed to evaluate the safety of remifentanil in a consecutive series of patients. During the study period, 540 transsphenoidal operations were identified. Of these, 443 (82.0%) patients received remifentanil intra-operatively; 97 (18.0%) did not. The two groups were well-matched with regard to demographic categories, comorbidities, and pre-operative medications (p>0.05), except pre-operative tobacco use (p=0.021). Patients were also well-matched with regard to radiographic features and surgical techniques. Patients who received remifentanil were more likely to harbor a macroadenoma (78.1% vs. 67.0%, p=0.025), and had slightly longer anesthesia time on average (269.2minvs. 239.4min, p=0.024). All pathologic diagnoses were well-matched between the two groups, except that patients receiving remifentanil were more likely to harbor a non-functioning adenoma (46.5% vs. 26.8%, p<0.001). Analysis of post-operative complications showed no significant difference between patients who received remifentanil and those who did not, and length of stay and prevalence of ICU stay did not differ between the two groups. In a well-matched series of 540 patients undergoing transsphenoidal surgery, remifentanil was found to be a safe anesthetic adjunct. There were no significant differences in post-operative hospital course or complications in patients who did and did not receive intra-operative remifentanil.
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States. Electronic address: david_cote@hms.harvard.edu.
authors.forename: David J
authors.initials: DJ
authors.lastname: Cote
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States.
authors.forename: William T
authors.initials: WT
authors.lastname: Burke
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Castlen
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, United States.
authors.forename: Chih H
authors.initials: CH
authors.lastname: King
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States.
authors.forename: Hasan A
authors.initials: HA
authors.lastname: Zaidi
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Smith
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States.
authors.forename: Edward R
authors.initials: ER
authors.lastname: Laws
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, United States.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Aglio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects; D011183:Postoperative Complications / Q000139:chemically induced / Q000175:diagnosis*; D000077208:Remifentanil; D012189:Retrospective Studies; D013101:Sphenoid Sinus / Q000601:surgery*; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil
keywords: Complication; Remifentanil; Safety; Transsphenoidal surgery