title: Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain.
abstract: β-cryptoxanthin, a xanthophyll carotenoid, exerts preventive effects on various lifestyle-related diseases. Here, we found that daily oral administration of β-cryptoxanthin significantly ameliorated the development of tactile allodynia following spinal nerve injury but was ineffective in mechanical allodynia in an inflammatory pain model in mice. Our results suggest that β-cryptoxanthin supplementation would be beneficial for the prophylaxis of neuropathic pain.
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Gyujin
authors.initials: G
authors.lastname: Park
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Horie
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Iezaki
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Maika
authors.initials: M
authors.lastname: Okamoto
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fukasawa
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanayama
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Kakeru
authors.initials: K
authors.lastname: Ozaki
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Onishi
authors.affiliation: b Citrus Research Division , Institute of Fruit Tree and Tea Science, National Agriculture and Food Research Organization , Shizuoka , Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Sugiura
authors.affiliation: a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Hinoi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000072743:Beta-Cryptoxanthin / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D019587:Dietary Supplements; D008297:Male; D051379:Mice; D009437:Neuralgia / Q000188:drug therapy*
chemical_list: D000072743:Beta-Cryptoxanthin
keywords: allodynia; neuropathic pain; β-cryptoxanthin