title: Exosomes in Cancer Diagnostics.
abstract: Exosomes are endosome derived extracellular vesicles of 30-120 nm size ranges. Exosomes have been identified as mediators of cell-to-cell communication by transferring bioactive molecules such as nucleic acids, proteins and lipids into recipient cells. While exosomes are secreted by multiple cell types, cancer derived exosomes not only influence the invasive potentials of proximally located cells, but also affect distantly located tissues. Based on their ability to alter tumor microenvironment by regulating immunity, angiogenesis and metastasis, there has been growing interest in defining the clinical relevance of exosomes in cancers. In particular, exosomes are valuable sources for biomarkers due to selective cargo loading and resemblance to their parental cells. In this review, we summarize the recent findings to utilize exosomes as cancer biomarkers for early detection, diagnosis and therapy selection.
authors.affiliation: Department of Pathology, Stony Brook Medicine, 101 Nicolls Road, Stony Brook, NY 11794, USA. younghwa.song@stonybrookmedicine.edu.
authors.forename: Young Hwa
authors.initials: YH
authors.lastname: Soung
authors.affiliation: Department of Pathology, Stony Brook Medicine, 101 Nicolls Road, Stony Brook, NY 11794, USA. shane.ford@stonybrook.edu.
authors.forename: Shane
authors.initials: S
authors.lastname: Ford
authors.affiliation: Department of Pathology, Stony Brook Medicine, 101 Nicolls Road, Stony Brook, NY 11794, USA. vincent.zhang@stonybrook.edu.
authors.forename: Vincent
authors.initials: V
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Stony Brook Medicine, 101 Nicolls Road, Stony Brook, NY 11794, USA. jun.chung@stonybrookmedicine.edu.
authors.forename: Jun
authors.initials: J
authors.lastname: Chung
keywords: biomarkers; cancer; exosomes