title: Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study.
abstract: An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung transplant recipients (LTRs).The lung function of 520 LTRs from the Cohort in Lung Transplantation (COLT) study was measured every 6 months. The levels of air pollutants (nitrogen dioxide (NO2), particulate matter with an aerodynamic cut-off diameter of x µm (PMx) and ozone (O3)) at the patients' home address were averaged in the 12 months before each spirometry test. The effects of air pollutants on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in % predicted were estimated using mixed linear regressions. We assessed the effect modification of macrolide antibiotics in this relationship.Increased 12-month levels of pollutants were associated with lower levels of FVC % pred (-2.56%, 95% CI -3.86--1.25 for 5 µg·m-3of PM10; -0.75%, 95% CI -1.38--0.12 for 2 µg·m-3of PM2.5and -2.58%, 95% CI -4.63--0.53 for 10 µg·m-3of NO2). In patients not taking macrolides, the deleterious association between PM and FVC tended to be stronger and PM10was associated with lower FEV1Our study suggests a deleterious effect of chronic exposure to air pollutants on lung function levels in LTRs, which might be modified with macrolides.
authors.affiliation: Université Grenoble Alpes, CNRS UMR 5309, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.|INSERM U1209, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.|CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.
authors.forename: Meriem
authors.initials: M
authors.lastname: Benmerad
authors.affiliation: Université Grenoble Alpes, CNRS UMR 5309, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.|INSERM U1209, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.|CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.
authors.forename: Rémy
authors.initials: R
authors.lastname: Slama
authors.affiliation: Institut du Thorax - INSERM UMR 1087/CNRS UMR 6291, CHU de Nantes, Nantes, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Botturi
authors.affiliation: Université Grenoble Alpes, Grenoble, France.|Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, CHU de Grenoble, INSERM U1055, Grenoble, France.
authors.forename: Johanna
authors.initials: J
authors.lastname: Claustre
authors.affiliation: Thoracic Surgery Dept, Foch Hospital, Université Versailles Saint-Quentin-en-Yvelines, UPRES EA220, Suresnes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Roux
authors.affiliation: Thoracic Surgery Dept, Foch Hospital, Université Versailles Saint-Quentin-en-Yvelines, UPRES EA220, Suresnes, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Sage
authors.affiliation: Service de Pneumologie et transplantation pulmonaire, Centre de Compétences des Maladies rares Pulmonaires et de l'Hypertension Pulmonaire, CHU Nord de Marseille, Aix Marseille Université, Marseille, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Reynaud-Gaubert
authors.affiliation: Service de Pneumologie et transplantation pulmonaire, Centre de Compétences des Maladies rares Pulmonaires et de l'Hypertension Pulmonaire, CHU Nord de Marseille, Aix Marseille Université, Marseille, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Gomez
authors.affiliation: Pôle Pathologie thoracique, CHU de Strasbourg, Strasbourg, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Kessler
authors.affiliation: Unité Pneumologie, Hôpital Bichat, Claude-Bernard AP-HP, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Brugière
authors.affiliation: Université de Lyon, Université Lyon 1, UMR754 INRA, Hospices civils de Lyon, Lyon, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mornex
authors.affiliation: Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardiopulmonaire Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.
authors.forename: Sacha
authors.initials: S
authors.lastname: Mussot
authors.affiliation: Chirurgie thoracique, Hôpital Larrey, CHU de Toulouse, Toulouse, France.
authors.forename: Marcel
authors.initials: M
authors.lastname: Dahan
authors.affiliation: Chirurgie cardiovasculaire, Hôpital Européen Georges-Pompidou H.E.G.P. AP-HP, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Boussaud
authors.affiliation: Service de pneumologie, CHU de Nantes, Nantes, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Danner-Boucher
authors.affiliation: Unité d'insuffisance respiratoire et transplantation, CHU de Bordeaux, Bordeaux, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Dromer
authors.affiliation: Service de pneumologie, Hôpital Erasme, Brussels, Belgium.
authors.forename: Christiane
authors.initials: C
authors.lastname: Knoop
authors.affiliation: Météo France, Lyon, France.
authors.forename: Annick
authors.initials: A
authors.lastname: Auffray
authors.affiliation: Université Grenoble Alpes, CNRS UMR 5309, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.|INSERM U1209, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.|CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.
authors.forename: Johanna
authors.initials: J
authors.lastname: Lepeule
authors.affiliation: Direction des Risques Chroniques, INERIS, Verneuil-en-Halatte, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Malherbe
authors.affiliation: Direction des Risques Chroniques, INERIS, Verneuil-en-Halatte, France.
authors.forename: Frederik
authors.initials: F
authors.lastname: Meleux
authors.affiliation: Service de Pneumologie, CHU Vaudois, Lausanne, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Nicod
authors.affiliation: Institut du Thorax - INSERM UMR 1087/CNRS UMR 6291, CHU de Nantes, Nantes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Magnan
authors.affiliation: Université Grenoble Alpes, Grenoble, France.|Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, CHU de Grenoble, INSERM U1055, Grenoble, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pison
authors.affiliation: Université Grenoble Alpes, CNRS UMR 5309, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France valerie.siroux@univ-grenoble-alpes.fr.|INSERM U1209, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.|CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Siroux
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000397:Air Pollution / Q000009:adverse effects*; D064591:Allografts; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000503:physiopathology; D002908:Chronic Disease; D004781:Environmental Exposure; D005260:Female; D005541:Forced Expiratory Volume; D005602:France; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008168:Lung / Q000503:physiopathology*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000032:analysis; D010126:Ozone / Q000032:analysis; D052638:Particulate Matter / Q000032:analysis*; D055031:Primary Graft Dysfunction / Q000503:physiopathology*; D013147:Spirometry; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D052638:Particulate Matter; D010126:Ozone; D009585:Nitrogen Dioxide