title: Identification of Phenolic Compounds from Hancornia speciosa (Apocynaceae) Leaves by UHPLC Orbitrap-HRMS.
abstract: Apocynaceae is a botanical family distributed mainly in tropical and subtropical regions of the world. In Brazil, they comprise about 90 genera and 850 species, inhabiting various types of vegetation. Within this large botanical family, the genusHancorniais considered monotypic, with its only speciesHancornia speciosaGomes. Antihypertensive, antidiabetic, and antiviral activities are described for this species. Despite having been the target of some studies, knowledge of its chemical composition is still limited. In this study, the phenolics ofH. speciosaleaves were analyzed using ultra-high performance liquid chromatography (UHPLC) coupled to Orbitrap high-resolution mass spectrometry (HRMS). As a result, 14 compounds were identified viz. protocatechuic acid, catechin, and quercetin, and another 14 were putatively identified viz. B- and C-type procyanidins, while just one compound remained unknown. From the identified compounds, 17 are reported for the first time viz. coumaroylquinic acid isomers and eriodyctiol. The results show thatHancornia speciosacan serve as source of valuable phenolics.
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil. katherine_xb@hotmail.com.
authors.forename: Katherine Xavier
authors.initials: KX
authors.lastname: Bastos
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil. clarice@ltf.ufpb.br.|Dept. Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, Halle 06120, Germany. clarice@ltf.ufpb.br.
authors.forename: Clarice Noleto
authors.initials: CN
authors.lastname: Dias
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil. yurimangueira@ltf.ufpb.br.
authors.forename: Yuri Mangueira
authors.initials: YM
authors.lastname: Nascimento
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil. marcelosobral@ltf.ufpb.br.
authors.forename: Marcelo Sobral
authors.initials: MS
authors.lastname: da Silva
authors.affiliation: Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal 59010-180, Brazil. silvanazucolotto@ufrnet.br.
authors.forename: Silvana Maria Zucolotto
authors.initials: SM
authors.lastname: Langassner
authors.affiliation: Dept. Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, Halle 06120, Germany. wessjohann@ipb-halle.de.
authors.forename: Ludger A
authors.initials: LA
authors.lastname: Wessjohann
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil. josean@ltf.ufpb.br.
authors.forename: Josean Fechine
authors.initials: JF
authors.lastname: Tavares
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000737:chemistry / Q000627:therapeutic use; D029062:Apocynaceae / Q000737:chemistry*; D001938:Brazil; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use; D013058:Mass Spectrometry; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000959:Antihypertensive Agents; D000998:Antiviral Agents; D007004:Hypoglycemic Agents; D010636:Phenols; D010936:Plant Extracts; D044945:Proanthocyanidins
keywords: Hancornia speciosa; Orbitrap; UHPLC; chemical composition; mangabeira; phenolic compounds