title: Invasive Candida krusei infection and Candida vasculitis of a leg ulcer in an immunocompetent patient: A case report.
abstract: A 71year old female Caucasian farmer without any known immunosuppression presented with a painful ulcer of her right lower leg after a trauma caused by a wood billet. There was no response to empirical antibacterial treatment. An ulcer biopsy showed an invasive Candida infection of the soft tissue and leucocytoclastic vasculitis. Voriconazole treatment was followed by wound healing. Invasive Candida infection and localized Candida vasculitis represent a rare cause of persisting leg ulcers. The similar clinical picture of chronic venous leg ulcers might blur the true cause and refractory cases should therefore promptly be processed by histopathological diagnostics.
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Electronic address: philipp.jud@medunigraz.at.
authors.forename: Philipp
authors.initials: P
authors.lastname: Jud
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Valentin
authors.affiliation: Institute of Pathology, Medical University Graz, Graz, Austria.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Regauer
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gary
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Gerald
authors.initials: G
authors.lastname: Hackl
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Rief
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Marianne
authors.initials: M
authors.lastname: Brodmann
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Hafner
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D002175:Candida; D002177:Candidiasis / Q000150:complications* / Q000178:diet therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy / Q000382:microbiology*; D014657:Vasculitis / Q000188:drug therapy / Q000382:microbiology*; D065819:Voriconazole / Q000627:therapeutic use; D014945:Wound Healing
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole
keywords: Candida krusei; candida vasculitis; invasive candidiasis; ulcer