title: Heparin triggered dose dependent multi-color emission switching in water: a convenient protocol for heparinase I estimation in real-life biological fluids.
abstract: Oligo(p-phenylenevinylene) based bis-pyridinium derivatives show 'ratiometric' detection of heparin in water. For the first time, we present a dose-dependent, multi-color emission switching in the presence of heparin. The reversible self-assembly of probes with heparin as the stimulus is also exploited for the screening of heparinase I enzyme.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. sb@orgchem.iisc.ernet.in.
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Dey
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. sb@orgchem.iisc.ernet.in.
authors.forename: Suman K
authors.initials: SK
authors.lastname: Samanta
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. sb@orgchem.iisc.ernet.in.
authors.forename: Santanu
authors.initials: S
authors.lastname: Bhattacharya
mesh_terms: D003116:Color; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D006493:Heparin / Q000032:analysis* / Q000378:metabolism*; D019763:Heparin Lyase / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D011726:Pyridinium Compounds / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D011726:Pyridinium Compounds; D014867:Water; D006493:Heparin; D019763:Heparin Lyase