title: Beta-blockers reduced the risk of cardiac rupture in patients with acute myocardial infarction: A meta-analysis of randomized control trials.
abstract: BACKGROUND
  Cardiac rupture (CR) is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition. The objective of this meta-analysis was to assess the effect of beta-blockers on CR in patients with acute MI.
  
  
  METHODS
  An extensive search of the PUBMED, EMBASE, ISI Web of Science, MEDLINE and Cochrane was performed to retrieve the studies of beta-blockers treatment in patients with acute MI. Data were combined using a random effects model. A meta-analysis was performed using Review Manager 5.3.
  
  
  RESULTS
  Four randomized controlled trials (RCTs) involving 68, 842 patients, 603 of whom occurred CR, were met criteria. Meta analysis showed that beta-blockers caused a statistically and clinically significant decrease in the incidence of CR of 32% (RR: 0.68, 95% CI: 0.47 to 0.99, P=0.04).
  
  
  CONCLUSIONS
  The findings of this meta-analysis confirmed that the early use of beta-blockers is associated with decreased incidence of CR, suggesting some beneficial effects of beta-blockers on infarct healing after acute MI.
authors.affiliation: Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.affiliation: Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.
authors.forename: Siting
authors.initials: S
authors.lastname: Feng
authors.affiliation: Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.
authors.forename: Jingyao
authors.initials: J
authors.lastname: Fan
authors.affiliation: Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.
authors.forename: Aobo
authors.initials: A
authors.lastname: Li
authors.affiliation: Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China. Electronic address: spnie@126.com.
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D006342:Heart Rupture, Post-Infarction / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: Acute MI; Beta-blockers; CR; Meta analysis; RCTs