title: Lanthanide coordination polymer probe for time-gated luminescence sensing of pH in undiluted human serum.
abstract: Lanthanide coordination polymers (LCPs) have emerged as fascinating materials because of their specific structure and properties. In this work, utilizing hydrosoluble biomolecule of guanosine-5'-monophosphate (GMP) as bridging linker, lanthanide terbium ions (Tb3+) as metal nodes, and silver ions (Ag+) as sensitizers, we synthesized a pH responsive luminescent lanthanide CP probe of Tb/GMP/Ag. The probe possesses high luminescence due to the sensitization of Ag+; While in alkaline solutions, Ag+in Tb/GMP/Ag immediately binds to OH-, forming Ag2O precipitation and resulting in a distinct fluorescence quenching of Tb/GMP/Ag. This probe displays high selectivity for OH-and a broader pH detection range of 7.5-13.0. In addition, based on the high anti-interference ability in serum, we applied Tb/GMP/Ag to measure pH in undiluted human serum samples, yielding satisfactory results.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
authors.forename: Yankai
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China. Electronic address: liubaoxia2005@163.com.
authors.forename: Baoxia
authors.initials: B
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chang
authors.affiliation: Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China. Electronic address: qupeng0212@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Qu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China. Electronic address: xumaotian@sqnc.edu.cn.
authors.forename: Maotian
authors.initials: M
authors.lastname: Xu
mesh_terms: D006157:Guanosine Monophosphate / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D049408:Luminescent Agents / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D044967:Serum / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013725:Terbium / Q000737:chemistry*; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D049408:Luminescent Agents; D011108:Polymers; D014867:Water; D013725:Terbium; D012834:Silver; D006157:Guanosine Monophosphate
keywords: Fluorescence; Human serum; Lanthanide coordination polymers; Tb/GMP/Ag; pH