title: A phenotypic and mechanistic perspective on heterogeneity of HER2-positive breast cancers.
abstract: Analysis of gene expression and whole-genome features of 64 human epidermal growth factor 2 (HER2)-positive breast tumors supports the idea that their intrinsic heterogeneity actually reflects their cell of origin, suggesting thatHER2amplification is an embedded event in the natural history of these tumors. Possible mechanisms for this event involve breakage-fusion-bridge and chromothripsis.
authors.affiliation: Synergie Lyon Cancer, Plateforme de Bioinformatique 'Gilles Thomas' Centre Léon Bérard , Lyon, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ferrari
authors.affiliation: Synergie Lyon Cancer, Plateforme de Bioinformatique 'Gilles Thomas' Centre Léon Bérard , Lyon, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Sertier
authors.affiliation: Institut Curie, PSL Research University, Département de Pathologie, INSERM U934 , Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent-Salomon
authors.affiliation: Centre Hospitalier Universitaire de Minjoz, UMR INSERM 1098 , Besançon, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pivot
authors.affiliation: Institut National du Cancer, Département de Recherche Clinique , Boulogne-Billancourt, France.
authors.forename: Iris
authors.initials: I
authors.lastname: Pauporté
authors.affiliation: Univ. Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon , Lyon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Saintigny
authors.affiliation: Département d'Oncologie Moléculaire, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, INSERM, CNRS, Aix-Marseille Université , Marseille, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
authors.affiliation: Synergie Lyon Cancer, Plateforme de Bioinformatique 'Gilles Thomas' Centre Léon Bérard, Lyon, France; INRIA Grenoble-Rhône-Alpes, Montbonnot-Saint Martin, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Viari
keywords: Breakage-Fusion-Bridge; Breast cancer; ERBB2 amplification; cancer genomics; mammary epithelial hierarchy