title: Preparation and Properties of Bamboo Fiber/Nano-hydroxyapatite/Poly(lactic-co-glycolic) Composite Scaffold for Bone Tissue Engineering.
abstract: In this study, bamboo fiber was first designed to incorporate into nano-hydroxyapatite/poly(lactic-co-glycolic) to obtain a new composite scaffold of bamboo fiber/nano-hydroxyapatite/poly(lactic-co- glycolic) (BF/n-HA/PLGA) by freeze-drying method. The effect of their components and some factors consisting of different freeze temperatures, concentrations, and pore-forming agents on the porous morphology, porosity, and compressive properties of the scaffold were investigated by scanning electron microscope, modified liquid displacement method, and electromechanical universal testing machine. The results indicated that the 5% BF/30% n-HA/PLGA composite scaffold, prepared with 5% (w/v) high concentration and frozen at -20 °C without pore-forming agent, had the best ideal porous structure and porosity as well as compressive properties, which far exceed those of n-HA/PLGA composite scaffold. In addition, the in vitro simulated body fluids soaking and cell culture experiment showed the addition of BF into the scaffold accelerated the BF/n-HA/PLGA composite scaffolds degradation and exhibited good cytocompatibility, including attachment and proliferation. All the results of the study show that BF has improved the properties of n-HA/PLGA composite scaffolds and BF/n-HA/PLGA might have a great potential for bone tissue engineering scaffold.
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University , Changsha 410081, People's Republic of China.|National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, College of Chemistry and Chemical Engineering, Hunan Normal University , Changsha 410081, People's Republic of China.
authors.forename: Liuyun
authors.identifier: http://orcid.org/0000-0002-8592-5736
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Li
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Chengdong
authors.initials: C
authors.lastname: Xiong
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University , Changsha 410081, People's Republic of China.|National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, College of Chemistry and Chemical Engineering, Hunan Normal University , Changsha 410081, People's Republic of China.
authors.forename: Shengpei
authors.initials: S
authors.lastname: Su
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University , Changsha 410081, People's Republic of China.|National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, College of Chemistry and Chemical Engineering, Hunan Normal University , Changsha 410081, People's Republic of China.
authors.forename: Haojie
authors.initials: H
authors.lastname: Ding
mesh_terms: D001672:Biocompatible Materials; D017886:Durapatite; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer / Q000737:chemistry*; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D017886:Durapatite
keywords: bamboo fiber; degradation; nano-hydroxyapatite; poly(lactic-co-glycolic); scaffold