title: Effect of Mifepristone on Corticosteroid Production in Vitro by Adrenal Glands of Rats with Streptozotocin Diabetes.
abstract: Changes in pregnenolone and corticosterone production by the adrenal glands of normoglycemic rats receiving the course of intraperitoneal mifepristone or NaCl administration were co-directed, but differed in magnitude. In rats with hyperglycemia, corticosteroid production increased after NaCl administration over 5 days and returned to the initial values after 15-day administration. On the contrary, pregnenolone and corticosterone production was suppressed after 5-day course of mifepristone, but significantly increased after mifepristone administration for 15 days. Intraperitoneal mifepristone administration almost completely abolished the response of rat adrenal glands with normo- and hyperglycemia to ACTH in vitro; this effect did not depend on the duration of administration.
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Kuznetsova
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia. labend@mail.ru.
authors.forename: N A
authors.initials: NA
authors.lastname: Palchikova
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Selyatitskaya
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Kuzminova
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D006727:Hormone Antagonists / Q000494:pharmacology*; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D015735:Mifepristone / Q000494:pharmacology*; D009924:Organ Culture Techniques; D011284:Pregnenolone / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology; D013311:Streptozocin
chemical_list: D006727:Hormone Antagonists; D015735:Mifepristone; D012965:Sodium Chloride; D013311:Streptozocin; D011284:Pregnenolone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
keywords: adrenal glands; in vitro corticosteroid production; sensitivity to ACTH; streptozotocin-induced diabetes