title: Association of GWAS Top Genes With Late-Onset Alzheimer's Disease in Colombian Population.
abstract: OBJECTIVE
  The association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer's disease (LOAD) was evaluated and confirmed through genome-wide association study. However, it is unknown whether these associations can be replicated in admixed populations.
  
  
  METHODS
  The association of 14 single-nucleotide polymorphisms in those genes was evaluated in 280 LOAD cases and 357 controls from the Colombian population.
  
  
  RESULTS
  In a multivariate analysis using age, gender, APOE∊4 status, and admixture covariates, significant associations were obtained ( P < .05) for variants in BIN1 (rs744373, odds ratio [OR]: 1.42), CLU (rs11136000, OR: 0.66), PICALM (rs541458, OR: 0.69), ABCA7 (rs3764650, OR: 1.7), and CD33 (rs3865444, OR: 1.12). Likewise, a significant interaction effect was observed between CLU and CR1 variants with APOE.
  
  
  CONCLUSIONS
  This study replicated the associations previously reported in populations of European ancestry and shows that APOE variants have a regulatory role on the effect that variants in other loci have on LOAD, reflecting the importance of gene-gene interactions in the etiology of neurodegenerative diseases.
authors.affiliation: 1 Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Diana Jennifer
authors.initials: DJ
authors.lastname: Moreno
authors.affiliation: 1 Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Susana
authors.initials: S
authors.lastname: Ruiz
authors.affiliation: 2 Grupo de Neuropsicología, Universidad Surcolombiana, Neiva, Colombia.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Ríos
authors.affiliation: 3 Grupo de Neurociencias, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lopera
authors.affiliation: 4 Grupo de Medicina Genómica, Universidad Surcolombiana, Neiva, Colombia.
authors.forename: Henry
authors.initials: H
authors.lastname: Ostos
authors.affiliation: 5 Psicologia Clínica i Psicobiologia and Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Marc
authors.initials: M
authors.lastname: Via
authors.affiliation: 1 Grupo de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bedoya
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D003105:Colombia / Q000453:epidemiology; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D053327:Apolipoprotein E4
keywords: APOE∊4; GWAS; genetic admixture; genetic interaction; polymorphisms; susceptibility to late-onset Alzheimer’s disease