title: An examination of the factors affecting intestinal wall integrity in newborns at birth.
abstract: BACKGROUND
  An understanding of the factors that influence intestinal wall integrity during the transition from fetal to neonatal life is important to elucidate and minimize potential contributions to the development of intestinal pathologies in vulnerable newborns.
  
  
  OBJECTIVE
  To assess the factors affecting intestinal wall integrity of late preterm and term newborns at birth.
  
  
  METHODS
  The concentrations of serum intestinal fatty acid-binding protein (I-FABP) as biomarker of intestinal wall injury, superoxide dismutase (SOD), and glutathione peroxidase (Gpx) as parameters of oxidative stress, and blood gas analyses were measured in the arterial cord blood of 80 newborns, delivered by spontaneous vaginal delivery (labor group) or elective cesarean delivery (non-labor group).
  
  
  RESULTS
  Compared with the non-labor group, I-FABP, SOD, and Gpx levels were significantly higher in the labor group. I-FABP concentration was inversely correlated with pH and BE and positively correlated with SOD and Gpx concentrations, second stage of labor duration, and active pushing time.
  
  
  CONCLUSIONS
  This study demonstrates that oxidative stress at birth and prolonged second stage of labor may lead to the intestinal injury, which is reflected in increased serum concentration of I-FABP.
authors.affiliation: a Neonatology and Pediatric Intensive Care , Children's Hospital, University of Bonn , Bonn , Germany.
authors.forename: Soyhan
authors.initials: S
authors.lastname: Bagci
authors.affiliation: a Neonatology and Pediatric Intensive Care , Children's Hospital, University of Bonn , Bonn , Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Mensinga
authors.affiliation: a Neonatology and Pediatric Intensive Care , Children's Hospital, University of Bonn , Bonn , Germany.
authors.forename: David
authors.initials: D
authors.lastname: Katzer
authors.affiliation: b Department of Obstetrics and Prenatal Medicine , University of Bonn , Bonn , Germany.
authors.forename: Waltraut M
authors.initials: WM
authors.lastname: Merz
authors.affiliation: a Neonatology and Pediatric Intensive Care , Children's Hospital, University of Bonn , Bonn , Germany.|c Institute of Human Genetics , University of Bonn , Bonn , Germany.
authors.forename: Heiko
authors.initials: H
authors.lastname: Reutter
authors.affiliation: a Neonatology and Pediatric Intensive Care , Children's Hospital, University of Bonn , Bonn , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller
mesh_terms: D001784:Blood Gas Analysis; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature; D007413:Intestinal Mucosa / Q000502:physiology*; D007743:Labor, Obstetric / Q000097:blood*; D008297:Male; D018384:Oxidative Stress; D011247:Pregnancy; D012016:Reference Values
chemical_list: D050556:Fatty Acid-Binding Proteins
keywords: I-FABP; delivery; intestinal injury; newborn; oxidative stress