title: Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review.
abstract: Cutaneous leishmaniasis (CL) is a protozoan disease which is endemic in Iran. It is transmitted by thePhlebotomussand fly. The eyelid is rarely involved possibly because the movement of the lids impedes the sand fly from biting the skin in this region. Here, we report 6 rare cases of eyelid CL. The patients were diagnosed by skin scraping, culture, and PCR from the lesions. Skin scraping examination showedLeishmaniaspp. amastigotes in the cytoplasm of macrophages. Culture examination was positive forLeishmaniaspp. PCR was positive forLeishmania majorandLeishmania tropica. The lesions were disguised as basal cell carcinoma, chalazion, hordeolum, and impetigo. The patients were treated with intramuscular meglumine antimoniate (20 mg/kg/day) for at least 3 weeks. They showed a dramatic response, and the lesions almost completely disappeared. We emphasized the importance of clinical and diagnostic features of lesions, characterized the phylogenetic relationship of isolated parasites, and reviewed the literature on ocular leishmaniasis.
authors.affiliation: Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Mohammadpour
authors.affiliation: Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Motazedian
authors.affiliation: Molecular Dermatology Research Center, Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Handjani
authors.affiliation: Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Hatam
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000981:Antiprotozoal Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003584:Cytological Techniques; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000473:pathology*; D005143:Eyelids / Q000469:parasitology / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D007492:Iran; D007891:Leishmania / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage; D000077485:Meglumine Antimoniate; D008828:Microbiological Techniques; D008853:Microscopy; D009942:Organometallic Compounds / Q000008:administration & dosage; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate
keywords: Iran; Leishmania major; Leishmania tropica; PCR; cutaneous leishmaniasis; eyelid