title: One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp3)-H activations.
abstract: A novel approach toward quaternary carbon centered cyclobutanes through Pd(ii)-catalyzed sequential intramolecular methylene C-H alkylation and intermolecular methine C-H bond arylation, alkenylation, alkylation, alkynylation, allylation, benzylation or alkoxylation is described. These quaternary carbon centered cyclobutanes could be further diversified through Pd(ii)-catalyzed γ-C(sp3)-H bond activations. The synthetic utility of this novel approach was exemplified by its application to the synthesis of a bioactive small molecule.
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China. yrao@mail.tsinghua.edu.cn.
authors.forename: Xinglin
authors.initials: X
authors.lastname: Yang
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China. yrao@mail.tsinghua.edu.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Shan
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China. yrao@mail.tsinghua.edu.cn.
authors.forename: Zimo
authors.initials: Z
authors.lastname: Yang
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China. yrao@mail.tsinghua.edu.cn.
authors.forename: Guiyi
authors.initials: G
authors.lastname: Huang
authors.affiliation: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. shengcq@smmu.edu.cn.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Dong
authors.affiliation: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. shengcq@smmu.edu.cn.
authors.forename: Chunquan
authors.initials: C
authors.lastname: Sheng
authors.affiliation: MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China. yrao@mail.tsinghua.edu.cn.
authors.forename: Yu
authors.identifier: http://orcid.org/0000-0002-4356-8531
authors.initials: Y
authors.lastname: Rao