title: Serum trace elements are interrelated with hormonal imbalance in men with acute ischemic stroke.
abstract: The objective of the present study was to assess hormonal and trace element status in men suffering from acute ischemic stroke.
  
  
  METHODS
  21 acute ischemic stroke patients and 21 age- and body mass index-matched healthy volunteers were enrolled in the study. Serum trace elements were assessed using inductively coupled plasma mass spectrometry. Serum hormones and brain damage markers were estimated using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Ischemic stroke patients are characterized by significantly higher levels of total and free triiodothyronine (T3), anti-thyroid peroxidase antibodies (Anti-TPO-Ab), prolactin, and cortisol, whereas the level of thyroid stimulating hormone (TSH) was decreased. Serum B, Cu, Li, Mn, Ni, Pb, Se, V, and Zn in stroke significantly exceeded the control values, whereas the level of Co and Fe was decreased. Correlation analysis revealed a significant association between serum B and T3, Anti-TPO-Ab, and iodine concentration; serum Li and Sr levels - with circulating TSH, free T3, and Anti-TPO-Ab; and V concentration - with total T3and I levels. The following positive relationships were also revealed: Co - TSH, Mn - free T3, Zn - free T3. Multiple linear regression demonstrated that Co, I, and Li were directly related to circulating TSH levels, whereas V concentration was negatively interrelated. In turn, only serum Li levels were characterized by a significant direct relationship with free T3 values.
  
  
  CONCLUSIONS
  Generally, the obtained data demonstrate that altered serum trace elements are associated with thyroid dysfunction in acute ischemic stroke patients. However, the causal relationship should be estimated.
authors.affiliation: All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, 117216, Russia; Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia; Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russia; RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia. Electronic address: skalny3@gmail.com.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Skalny
authors.affiliation: Institute of Chemical Physics of N. N. Semenov of the Russian Academy of Sciences, Kosygina St., 4, Moscow, 119991, Russia.
authors.forename: Lydmila L
authors.initials: LL
authors.lastname: Klimenko
authors.affiliation: Institute of Professional Development of Federal Medical-Biological Agency of Russia, Volokolamskoe St., 30, 1, Moscow, 123182, Russia.
authors.forename: Aliya A
authors.initials: AA
authors.lastname: Turna
authors.affiliation: Institute of Chemical Physics of N. N. Semenov of the Russian Academy of Sciences, Kosygina St., 4, Moscow, 119991, Russia.
authors.forename: Maria N
authors.initials: MN
authors.lastname: Budanova
authors.affiliation: Institute of Chemical Physics of N. N. Semenov of the Russian Academy of Sciences, Kosygina St., 4, Moscow, 119991, Russia.
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Baskakov
authors.affiliation: Clinical Hospital № 123 Federal Medical-Biological Agency of Russia, Odintsovo, Moscow Region, Russia.
authors.forename: Marina S
authors.initials: MS
authors.lastname: Savostina
authors.affiliation: Clinical Hospital № 123 Federal Medical-Biological Agency of Russia, Odintsovo, Moscow Region, Russia.
authors.forename: Aksana N
authors.initials: AN
authors.lastname: Mazilina
authors.affiliation: Institute of Chemical Physics of N. N. Semenov of the Russian Academy of Sciences, Kosygina St., 4, Moscow, 119991, Russia; N. I. Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow, 117997, Russia.
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Deyev
authors.affiliation: RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia.
authors.forename: Margarita G
authors.initials: MG
authors.lastname: Skalnaya
authors.affiliation: Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia; Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russia; RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia; Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Tinkov
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000097:blood*; D004958:Estradiol / Q000097:blood; D006801:Humans; D007455:Iodine / Q000097:blood; D008297:Male; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D020521:Stroke / Q000097:blood*; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014131:Trace Elements; D014284:Triiodothyronine; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D013972:Thyrotropin; D007455:Iodine
keywords: Boron; Brain ischemia; Iodine; Lithium; Stroke; Thyroid