title: Head and neck sarcomas: A single institute series.
abstract: Sarcomas are tumours of mesenchymal origin, accounting for 1% of all malignancies.
  
  
  
  This is a retrospective analysis of 107 head and neck sarcoma cases, treated over a period of thirteen years.
  
  
  
  Fifty-four patients had with craniofacial bone sarcomas (BSs) (male: 33; female: 21) with high grade osteosarcoma being the most predominant type. The soft tissue sarcomas (STS) (53 patients; male: 28, female: 25) were histologically diverse with rhabdomyosarcomas and myxofibrosarcomas being the predominant types. The majority of BSs were managed with neoadjuvant chemotherapy followed by surgery, whereas in STSs treatment included predominantly surgery followed by radiotherapy. Overall survival estimates were 79% at 2years and 64% at 5years (mean follow-up period was 48months).
  
  
  
  The mesenchymal origin of sarcomas, the pattern of disease spread and the different extent of cancellous bone infiltration in contrast to epithelial tumours, dictate distinct principles for surgical clearance.
authors.affiliation: University College London Hospital (UCLH), London, UK. Electronic address: leandros.vassiliou@nhs.net.
authors.forename: Leandros-Vassilios
authors.initials: LV
authors.lastname: Vassiliou
authors.affiliation: University College London Hospital (UCLH), London, UK.
authors.forename: Bagrat
authors.initials: B
authors.lastname: Lalabekyan
authors.affiliation: University College London Hospital (UCLH), London, UK.
authors.forename: Amrita
authors.initials: A
authors.lastname: Jay
authors.affiliation: University College London Hospital (UCLH), London, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Liew
authors.affiliation: University College London Hospital (UCLH), London, UK.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Whelan
authors.affiliation: The Queen Victoria Hospital, East Grinstead, UK.
authors.forename: Laurence
authors.initials: L
authors.lastname: Newman
authors.affiliation: University College London Hospital (UCLH), London, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Kalavrezos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D015996:Survival Rate; D055815:Young Adult
keywords: Head and neck; Mandible; Maxilla; Maxillofacial; Oncology; Oral; Osteosarcoma; Sarcoma