title: Chronic Pruritus in an 18-Month-Old Male Infant Due to Anicteric Cholestasis.
abstract: An 18-month-old male infant was referred to us with pruritus from 6 months of age. He was being managed as atopic eczema with emollients and antihistamines without any response to treatment. On examination, he was found to have extensive scratch marks, mild hepatomegaly and no icterus. Blood investigations were suggestive of anicteric cholestatic liver disease. Liver biopsy was suggestive of progressive familial intrahepatic cholestasis type 3. He showed symptomatic improvement after starting ursodeoxycholic acid and fat-soluble vitamins and is under follow up.
authors.affiliation: Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.
authors.forename: Vishnu S
authors.initials: VS
authors.lastname: Nair
authors.affiliation: Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Chandrasekaran
authors.affiliation: Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.
authors.forename: Barath
authors.initials: B
authors.lastname: Jagadisan
authors.affiliation: Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Biswal
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000172:deficiency* / Q000235:genetics; D001706:Biopsy; D002779:Cholestasis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D002908:Chronic Disease; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology*; D008297:Male; D011537:Pruritus / Q000209:etiology*; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D014580:Ursodeoxycholic Acid
keywords: anicteric cholestasis; chronic pruritus; infant; liver disease