title: Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.
abstract: Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC50value of 6.6 μg/mL. Phytochemical investigation of this extract led to the isolation of 15 compounds, including eight new cyclohexene chalcones (1-8). The structures of the new compounds were elucidated by NMR spectroscopic data analysis. Among the isolated compounds obtained, isopanduratin A1 (14) and nicolaioidesin C (15) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50values of 1.0 and 0.84 μM, respectively.
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
authors.forename: Nhan Trung
authors.identifier: 0000-0001-5142-4573
authors.initials: NT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
authors.forename: Mai Thanh Thi
authors.initials: MT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
authors.forename: Hai Xuan
authors.identifier: 0000-0001-8447-8367
authors.initials: HX
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
authors.forename: Phu Hoang
authors.initials: PH
authors.lastname: Dang
authors.affiliation: Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Dya Fita
authors.initials: DF
authors.lastname: Dibwe
authors.affiliation: Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-8510, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Esumi
authors.affiliation: Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002599:Chalcone / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003510:Cyclohexanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D003510:Cyclohexanes; D010936:Plant Extracts; C000621551:isopanduratin A1; C471531:nicolaioidesin C; D002599:Chalcone