title: Combining nanoscale magnetic nimodipine liposomes with magnetic resonance image for Parkinson's disease targeting therapy.
abstract: OBJECTIVE
  To enhance drug targeting and blood-brain barrier penetration for Parkinson's disease (PD), a novel nanoscale magnetic nimodipine (NMD) delivery system was designed and prepared.
  
  
  METHODS
  The PD rats were established and treated with free NMD or Fe3O4-modified NMD liposomes (Fe3O4-NMD-lips). Then, factional anisotropy values were measured by MRI to evaluate therapy efficacy.
  
  
  RESULTS
  Fe3O4-NMD-lips showed the best neuroprotective effect, and the NMD concentration of lesions was 2.5-fold higher in Fe3O4-NMD-lips group than that of free NMD group.
  
  
  CONCLUSIONS
  These results demonstrated that the magnetic drug system had a great potential to cross the blood-brain barrier and provided a noninvasive and effective therapeutic strategy for PD.
authors.affiliation: Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
authors.forename: Bingshuo
authors.initials: B
authors.lastname: Ji
authors.affiliation: Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
authors.forename: Meili
authors.initials: M
authors.lastname: Wang
authors.affiliation: Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.|State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Gao
authors.affiliation: Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xing
authors.affiliation: Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pathology, the First Hospital of Qinhuangdao, No. 258 Cultural Street, Qinhuangdao 066000, PR China.
authors.forename: Lanxiang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pathology, the First Hospital of Qinhuangdao, No. 258 Cultural Street, Qinhuangdao 066000, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pathology, the First Hospital of Qinhuangdao, No. 258 Cultural Street, Qinhuangdao 066000, PR China.
authors.forename: Ximing
authors.initials: X
authors.lastname: Qi
authors.affiliation: Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Dai
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D058990:Molecular Targeted Therapy; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D009553:Nimodipine / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D008081:Liposomes; D058185:Magnetite Nanoparticles; D018696:Neuroprotective Agents; D009553:Nimodipine
keywords: Parkinson's disease; blood–brain barrier; magnetic resonance imaging; nanoscale magnetic liposomes; nimodipine