title: Spotlight on the Use of Nitric Oxide in Dermatology: What Is It? What Does It Do? Can It Become an Important Addition to the Therapeutic Armamentarium for Skin Disease?
abstract: Nitric oxide (NO) is a diatomic gas that is synthesized within and released by multiple host cell types functioning to provide a variety of physiologic and homeostatic effects. Nitric oxide exhibits a variety of effects that relate significantly with outcomes that can provide therapeutic benefit if properly formulated and released. These include anti-inflammatory, immunomodulatory, antimicrobial, vasodilatory properties, and effects that are beneficial to wound healing. Lack of antibiotic resistance appears to be one major advantage of topically delivered NO. A specific topical formulation of NO has been developed that has been shown thus far in clinical studies to exhibit favorable efficacy and safety. This article provides a thorough review of the biologic effects of NO, discusses modes of action and potential pharmacologic benefits, and reviews currently available clinical data for acne. J Drugs Dermatol. 2017;16(1 Suppl 1):s4-10.
authors.forename: James Q
authors.initials: JQ
authors.lastname: Del Rosso
authors.forename: Leon H
authors.initials: LH
authors.lastname: Kircik
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000378:metabolism; D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000378:metabolism; D003880:Dermatology / Q000379:methods / Q000639:trends*; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000378:metabolism*; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D009569:Nitric Oxide