title: The cardiotoxicity of cetuximab as single therapy in Chinese chemotherapy-refractory metastatic colorectal cancer patients.
abstract: The cardiac safety of cetuximab, particularly as single approach, has not been investigated extensively. This trial was designed to evaluate the cardiac safety of cetuximab as salvage monotherapy in Chinese chemotherapy-refractory metastatic colorectal cancer (mCRC) patients.Cetuximab was administrated at an initial dose of 400 mg/mon day 1 (week 1), followed by a maintenance dose of 250 mg/m on day 1 of each 7-day cycle. Electrocardiograph (ECG), routine laboratory tests, and troponin I (TNI) Ultra were performed at baseline, during, and after the cetuximab therapy. The incidence of abnormal ECGs, elevated TNI Ultra, cardiac events, and noncardiac events were recorded and analyzed.TNI Ultra+ was found in 20 patients (32.3%) during the cetuximab therapy.TNI Ultra+ occurred more frequently in patients with more than 3 organs affected and accepted fourth or above lines of chemotherapy. The most frequent abnormal ECG was ST depression in 24 (38.7%) patients. The elevated TNI Ultra and abnormal ECGs could recover after the cetuximab therapy. The most of cardiac adverse events were mild and transient and the noncardiac adverse events were also consistent with the known safety profile for cetuximab.Cetuximab showed its cardiac safety as a single agent for chemotherapy-refractory mCRC patients. And TNI Ultra and ECG could be sensitive and convenient approaches for the surveillance of adverse events.
authors.affiliation: Department of Ultrasound and Electrocardiogram Department of Clinical Laboratory Department of Radiation Oncology Department of Nursing, Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
authors.forename: Xue-Miao
authors.initials: XM
authors.lastname: Tang
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Bin-Lian
authors.initials: BL
authors.lastname: Huang
authors.forename: Xiu-Quan
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Yuan
authors.forename: Xia
authors.initials: X
authors.lastname: He
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000230:Adenocarcinoma / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000009:adverse effects; D000068818:Cetuximab / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004562:Electrocardiography; D006331:Heart Diseases / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D019210:Troponin I / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D000068818:Cetuximab; D019210:Troponin I