title: Choline-based imaging of prostate cancer with combined [18F] fluorocholine PET and1H MR spectroscopy by means of integrated PET/MRI.
abstract: OBJECTIVE
  To evaluate integrated PET/MRI/1H MR spectroscopy in patients with prostate cancer.
  
  
  METHODS
  Data analysis comprised calculations of correlations of standardized uptake values (SUVs) and ratios of (choline+creatine)/citrate as well as of single metabolite values and a logistic regression analysis of PET data and MR spectroscopy data in 22 patients.
  
  
  RESULTS
  SUVmean and integral values of choline correlated significantly in tumors. Logistic regression analysis demonstrated diagnostic superiority of PET over spectroscopy.
  
  
  CONCLUSIONS
  Simultaneous acquisition of PET and MR spectroscopy with integrated PET/MRI is feasible. Choline compounds and choline metabolism show a positive significant correlation.
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany. Electronic address: axel.wetter@uk-essen.de.
authors.forename: Axel
authors.initials: A
authors.lastname: Wetter
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Grüneisen
authors.affiliation: Department of Psychiatry, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Fliessbach
authors.affiliation: Department of Nuclear Medicine, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Lütje
authors.affiliation: Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Schaarschmidt
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany.
authors.forename: Lale
authors.initials: L
authors.lastname: Umutlu
mesh_terms: D000368:Aged; D002794:Choline / Q000031:analogs & derivatives; D003401:Creatine; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: C514960:fluorocholine; D003401:Creatine; D002794:Choline
keywords: MR spectroscopy; Molecular imaging; PET/MRI; Prostate cancer; [(18)F] choline