title: Ureaplasma Transmitted From Donor Lungs Is Pathogenic After Lung Transplantation.
abstract: Hyperammonemia is a highly fatal syndrome in lung recipients that is usually refractory to medical therapy. We recently reported that infection by a Mollicute, Ureaplasma, is causative for hyperammonemia and can be successfully treated with antimicrobial agents. However, it remains unknown whether the pathogenic strain of Ureaplasma is donor or recipient derived. Here we provide evidence that donor-derived Ureaplasma infection can be pathogenic. As such, we uncover a previously unknown lethal donor-derived opportunistic infection in lung recipients. Given the high mortality associated with hyperammonemia, strategies for routine donor screening or prophylaxis should be further evaluated in prospective studies.
authors.affiliation: Division of Thoracic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Ramiro
authors.initials: R
authors.lastname: Fernandez
authors.affiliation: Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Amy
authors.initials: A
authors.lastname: Ratliff
authors.affiliation: Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Donna
authors.initials: D
authors.lastname: Crabb
authors.affiliation: Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Ken B
authors.initials: KB
authors.lastname: Waites
authors.affiliation: Division of Thoracic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: abharat@nm.org.
authors.forename: Ankit
authors.initials: A
authors.lastname: Bharat
mesh_terms: D000328:Adult; D046148:Donor Selection / Q000379:methods*; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D011183:Postoperative Complications; D013902:Radiography, Thoracic; D014509:Ureaplasma / Q000302:isolation & purification*; D016869:Ureaplasma Infections / Q000175:diagnosis / Q000382:microbiology / Q000635:transmission*