title: Disruption of aromatase homeostasis as the cause of a multiplicity of ailments: A comprehensive review.
abstract: Human health is beset with a legion of ailments, which is exacerbated by lifestyle errors. Out of the numerous enzymes in human body, aromatase, a cytochrome P450 enzyme is particularly very critical. Occurring at the crossroads of multiple signalling pathways, its homeostasis is vital for optimal health. Unfortunately, medications, hormone therapy, chemical additives in food, and endocrine-disrupting personal care products are oscillating the aromatase concentration beyond the permissible level. As this enzyme converts androgens (C19) into estrogens (C18), its agitation has different outcomes in different genders and age groups. Some common pathologies associated with aromatase disruption include breast cancer, prostate cancer, polycystic ovary syndrome (PCOS), endometriosis, osteoporosis, ovarian cancer, gastric cancer, pituitary cancer, Alzheimer's disease, schizophrenia, male hypogonadism, and transgender issues. Several drugs, cosmetics and pesticides act as the activators and suppressors of this enzyme. This carefully-compiled critical review is expected to increase public awareness regarding the threats resultant of the perturbations of this enzyme and to motivate researchers for further investigation of this field.
authors.affiliation: Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, CA 92182, USA. Electronic address: seemabiotech83@gmail.com.
authors.forename: Seema
authors.initials: S
authors.lastname: Patel
mesh_terms: D000728:Androgens / Q000737:chemistry; D001141:Aromatase / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D047072:Aromatase Inhibitors / Q000737:chemistry; D001943:Breast Neoplasms / Q000097:blood; D004703:Endocrine System; D004715:Endometriosis / Q000097:blood; D004967:Estrogens / Q000737:chemistry; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood; D010024:Osteoporosis / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood; D010575:Pesticides / Q000737:chemistry; D011085:Polycystic Ovary Syndrome / Q000097:blood; D011247:Pregnancy; D011471:Prostatic Neoplasms / Q000097:blood; D015398:Signal Transduction; D063106:Transgender Persons
chemical_list: D000728:Androgens; D047072:Aromatase Inhibitors; D004967:Estrogens; D010575:Pesticides; D001141:Aromatase; C561410:CYP19A1 protein, human
keywords: Aromatase; Aromatase inhibitor; Breast cancer; Endocrine disruption; Estrogen; Inflammation