title: Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.
abstract: The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal.
authors.affiliation: Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Guojun
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Nursing, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Traffic Police Department, Jinan Public Security Bureau, Jinan 250021, Shandong, P. R. China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shi
authors.affiliation: Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Geng
authors.affiliation: Scientific Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
authors.forename: Xingsong
authors.initials: X
authors.lastname: Tian
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D018938:Caco-2 Cells; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects* / Q000473:pathology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects*; D011807:Quinolizines / Q000494:pharmacology*; D011897:Random Allocation; D054400:Receptors, CCR7 / Q000378:metabolism*; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000871:Anthelmintics; D008070:Lipopolysaccharides; D011807:Quinolizines; D054400:Receptors, CCR7; D000093842:Matrines
keywords: CCR7; LPS; inflammation; matrine; oxidative stress