title: Successful outcome of three patients with sickle-cell disease and fat embolism syndrome treated with intensive exchange transfusion.
abstract: Fat embolism syndrome (FES) is a rare complication of sickle-cell disease (SCD) associated with extremely high mortality rates. It affects predominantly non-SS patients and those with previously mild disease. Rapid institution of exchange transfusion with an aim to reduce HbS to very low levels as soon as FES is suspected can be life-saving.
authors.affiliation: Haemoglobinopathy Service Department of Haematology Homerton University Hospital NHS Foundation Trust London UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Greaves
authors.affiliation: Haemoglobinopathy Service Department of Haematology Homerton University Hospital NHS Foundation Trust London UK.
authors.forename: Vivek
authors.initials: V
authors.lastname: Mathew
authors.affiliation: Intensive Care Unit Homerton University Hospital NHS Foundation Trust London UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Peters
authors.affiliation: Department of Radiology Homerton University Hospital NHS Foundation Trust London UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Rowe
authors.affiliation: Haemoglobinopathy Service Department of Haematology Homerton University Hospital NHS Foundation Trust London UK.
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Amos
authors.affiliation: Haemoglobinopathy Service Department of Haematology Homerton University Hospital NHS Foundation Trust London UK.
authors.forename: Dimitris A
authors.initials: DA
authors.lastname: Tsitsikas
keywords: Bone marrow necrosis; fat embolism syndrome; parvovirus B19; sickle cell; transfusion