title: Ecotoxicology of Glycerol Monolaurate nanocapsules.
abstract: Glycerol Monolaurate (GML) is a compound with known antimicrobial potential, however it is not much used due to its low solubility in water and high melting point. The nanoencapsulation of some drugs offers several advantages such as improved stability and solubility in water. The present study aimed to produce, characterize, and evaluate the ecotoxicity of GML nanocapsules. The nanocapsules were produced and presented a mean diameter of 210nm, polydispersity index of 0.044, and zeta potential of -23.4mV. The electron microscopy images showed the nanometric size and spherical shape. The assay in soil showed that GML has a high toxicity while the GML nanocapsules showed decreased toxic effects. Nanostructuration also protected the Rhamdia quelen against the toxic effects of GML. Concluding, the formulation shows positive results and is useful to predict the success of development besides not damaging the soil.
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, Brazil; Post-Graduate Program in Nanosciences, Centro Universitário Franciscano, Santa Maria, Brazil. Electronic address: leonardoquintanalopes@gmail.com.
authors.forename: Leonardo Q S
authors.initials: LQ
authors.lastname: Lopes
authors.affiliation: Post-Graduate Program in Nanosciences, Centro Universitário Franciscano, Santa Maria, Brazil.
authors.forename: Cayane G
authors.initials: CG
authors.lastname: Santos
authors.affiliation: Center of chemical, pharmaceutical and food sciences, Universidade Federal de Pelotas, Capão do Leão, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: de Almeida Vaucher
authors.affiliation: Post-Graduate Program in Nanosciences, Centro Universitário Franciscano, Santa Maria, Brazil.
authors.forename: Renata P
authors.initials: RP
authors.lastname: Raffin
authors.affiliation: Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, Brazil.
authors.forename: Aleksandro S
authors.initials: AS
authors.lastname: da Silva
authors.affiliation: Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, Brazil.
authors.forename: Dilmar
authors.initials: D
authors.lastname: Baretta
authors.affiliation: Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Maccari
authors.affiliation: Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, Brazil.
authors.forename: Laura Caroline D D
authors.initials: LC
authors.lastname: Giombelli
authors.affiliation: Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, Brazil.
authors.forename: Andreia
authors.initials: A
authors.lastname: Volpato
authors.affiliation: Departament of Fisiology and Farmacology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Jessyka
authors.initials: J
authors.lastname: Arruda
authors.affiliation: Departament of Fisiology and Farmacology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Cecília
authors.initials: C
authors.lastname: de Ávila Scheeren
authors.affiliation: Departament of Fisiology and Farmacology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Baldisserotto
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, Brazil; Post-Graduate Program in Nanosciences, Centro Universitário Franciscano, Santa Maria, Brazil; Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Roberto C V
authors.initials: RC
authors.lastname: Santos
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000633:toxicity; D001181:Arthropods / Q000187:drug effects / Q000254:growth & development*; D054750:Ecotoxicology; D004781:Environmental Exposure; D005399:Fishes / Q000254:growth & development*; D007848:Laurates / Q000633:toxicity*; D050178:Monoglycerides / Q000633:toxicity*; D053769:Nanocapsules / Q000633:toxicity*; D012989:Soil Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000890:Anti-Infective Agents; D007848:Laurates; D050178:Monoglycerides; D053769:Nanocapsules; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; C020777:monolaurin
keywords: Ecotoxicicity, Rhamdia quelen; Glycerol monolaurate; Nanotechnology; Springtail