title: Amplitude-integrated electroencephalography can predict neurodevelopmental outcome at 12 months of corrected age in very preterm infants.
abstract: OBJECTIVE
  It is difficult to find diagnostic tools than can reliably predict neurodevelopmental outcomes in very preterm infants in clinical practice. This study evaluated whether amplitude-integrated electroencephalography predicted neurodevelopmental outcome in preterm infants when they reached 12 months of corrected age.
  
  
  METHODS
  Between October 2007 and December 2013, we studied 232 preterm infants (51% male) at Innsbruck Medical University Hospital, Austria. Their mean birthweight was 1264 g, and their mean gestational age was 29.5 weeks. Amplitude-integrated electroencephalography was evaluated using the Burdjalov score, and outcomes were assessed using the Bayley Scales of Infant Development - Second Edition.
  
  
  RESULTS
  The cohort was divided into three subgroups: 154 infants with normal outcomes, 53 infants with moderate delays and 25 infants with severe delays. The amplitude-integrated electroencephalography Burdjalov scores were lower in infants with moderate delays than in infants with normal outcomes and even lower in infants with severe delays. The highest area under the curve (0.776) for the Burdjalov score was at 18-24 hours of life.
  
  
  CONCLUSIONS
  Our study confirmed the predictive value of amplitude-integrated electroencephalography and showed that this needed to be carried out early in life to provide reliable information on neurodevelopmental outcomes in very preterm infants.
authors.affiliation: Department of Paediatrics II, Neonatology, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ralser
authors.affiliation: Department of Paediatrics II, Neonatology, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Vera
authors.initials: V
authors.lastname: Neubauer
authors.affiliation: Department of Paediatrics II, Neonatology, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Pupp-Peglow
authors.affiliation: Department of Paediatrics II, Neonatology, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Ursula
authors.initials: U
authors.lastname: Kiechl-Kohlendorfer
authors.affiliation: Department of Paediatrics II, Neonatology, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Elke
authors.initials: E
authors.lastname: Griesmaier
mesh_terms: D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis*; D004569:Electroencephalography / Q000592:standards*; D005260:Female; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008297:Male
keywords: Amplitude-integrated electroencephalography; Burdjalov score; Neurodevelopmental outcome; Preterm infant