title: Significant association between Let-7-KRAS rs712 G > T polymorphism and cancer risk in the Chinese population: a meta-analysis.
abstract: Association between let-7-KRAS rs712 polymorphism and cancer risk was inconsistent. We therefore conducted this meta-analysis to clarify the association between let-7-KRAS rs712 polymorphism and cancer risk with STATA 14.0 software. A systemic literature search in online databases (PubMed, Embase, CNKI and Wanfang database) was preformed to obtain relevant articles. A total of 13 case-control studies involving 3,453 patients and 4,470 controls were identified up to May 16, 2015. The pooled results indicated that significantly increased risk were observed in Chinese population in T vs. G (OR = 1.21, 95% CI = 1.03-1.42) and TT vs. GG + GT genetic models (OR = 1.69, 95% CI = 1.17-2.42). Sensitivity analysis was conducted and the result without heterogeneity showed significant associations in all five genetic models. Subgroup analyses of cancer type indicated a similar result in digestive cancer (for T vs. G: OR = 1.41, 95% CI = 1.26-1.57; GT vs. GG: OR = 1.24, 95% CI = 1.07-1.43; TT vs. GG: OR = 2.53, 95% CI = 1.86-3.44; GT + TT vs. GG: OR = 1.36, 95% CI = 1.19-1.56; TT vs. GG + GT: OR = 2.35, 95% CI = 1.73-3.19). In summary, these evidences demonstrate that let-7-KRAS rs712 G > T polymorphism might be associated with digestive system cancer risk in the Chinese population.
authors.affiliation: Department of Stomatology, People's Hospital of New District Longhua Shenzhen, Shenzhen 518109, China.
authors.forename: Xin-Ya
authors.initials: XY
authors.lastname: Du
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Hu
authors.affiliation: Department of Stomatology, People's Hospital of New District Longhua Shenzhen, Shenzhen 518109, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Xie
authors.affiliation: Intensive Care Unit, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Deng
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Liu
authors.affiliation: Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Luo
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.|Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Niu
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, China.|Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
mesh_terms: D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*
chemical_list: C117307:KRAS protein, human; D035683:MicroRNAs; C487931:mirnlet7 microRNA, human; D016283:Proto-Oncogene Proteins p21(ras)
keywords: KRAS; cancer; let-7; polymorphism