title: Systemic nocardiosis in a dog caused by Nocardia cyriacigeorgica.
abstract: BACKGROUND
  Systemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs.
  
  
  METHODS
  Light and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes. The organism was isolated and sequencing of its 16S rRNA allowed its identification and speciation. Examination of the bacterial culture by scanning electron-microscope showed filamentous branching with fragmentation into widely bacillary and cocoid forms of the bacteria. There was no history of immunosupressive drug administration and infection by the immunosuppresive viral pathogens, canine distemper and parvovirus were excluded via PCR.
  
  
  CONCLUSIONS
  N. cyriacigeorgica should be considered potential cause of systemic pyogranulomatous lesions in dogs. It is the first reported case of systemic nocardiosis due to N. cyriacigeorgica in a dog.
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Firat University, 23 200, Elazig, Turkey. yeroksuz@firat.edu.tr.
authors.forename: Yesari
authors.initials: Y
authors.lastname: Eroksuz
authors.affiliation: Department of Medical Microbiology, School of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Nafia Canan
authors.initials: NC
authors.lastname: Gursoy
authors.affiliation: Department of Internal Medicine, School of Veterinary Medicine, Firat University, Elazig, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Karapinar
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Firat University, 23 200, Elazig, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Karabulut
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Firat University, 23 200, Elazig, Turkey.
authors.forename: Canan Akdeniz
authors.initials: CA
authors.lastname: Incili
authors.affiliation: Department of Microbiology, School of Veterinary Medicine, Firat University, Elazig, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Yerlikaya
authors.affiliation: Department of Medical Microbiology, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Zulal Asci
authors.initials: ZA
authors.lastname: Toraman
authors.affiliation: Department of Virology, School of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Mehmet Ozkan
authors.initials: MO
authors.lastname: Timurkan
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Firat University, 23 200, Elazig, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Eroksuz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D004285:Dogs; D009615:Nocardia / Q000145:classification*; D009617:Nocardia Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Canine nocardiosis; Nocardia cyriacigeorgica; Systemic involvement