title: Trachyspermum ammi Seeds Supplementation Helps Reverse Scopolamine, Alprazolam and Electroshock Induced Amnesia.
abstract: The present study was designed to explore the beneficial effects of successive 10 days administration of Trachyspermum ammi seed's powder (TASP) along with diet (at the dose of 0.5%, 1.0% and 2.0% w/w) on learning and memory of mice. A total of 306 mice divided in 51 equal groups were employed in the study. Passive avoidance paradigm (PAP) and Object recognition Task (ORT) were employed as exteroceptive models. The brain acetylcholinesterase activity (AChE), serum cholesterol, brain monoaldehyde (MDA), brain reduced glutathione (GSH) and brain nitrite were estimated and Alprazolam, Scopolamine and Electroshock induced amnesia was employed to describe the actions. Treatment of TASP significantly increased step down latency of PAA and significantly increased discrimination index of ORT in groups with or without amnesia when compared to respective control groups. Furthermore, TASP administration resulted in significant fall in brain AChE activity, brain MDA level and brain nitrite level with simultaneous rise in brain GSH level, thereby decreased oxidative damage. A significant decrease in serum cholesterol was also observed. Ajowan supplementation may prove a remedy for the management of cognitive disorders owing to have pro-cholinergic, antioxidant and hypo-lipidemic activities.
authors.affiliation: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, Haryana, India. kapilsoni.life@gmail.com.
authors.forename: Kapil
authors.initials: K
authors.lastname: Soni
authors.affiliation: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, Haryana, India.
authors.forename: Milind
authors.initials: M
authors.lastname: Parle
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000525:Alprazolam / Q000633:toxicity*; D000647:Amnesia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000818:Animals; D019661:Apiaceae; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004597:Electroshock / Q000009:adverse effects*; D005978:Glutathione / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D012601:Scopolamine / Q000633:toxicity*; D012639:Seeds
chemical_list: D010936:Plant Extracts; D012601:Scopolamine; D000110:Acetylcholinesterase; D005978:Glutathione; D000525:Alprazolam
keywords: Acetylcholine; Ajowan; Memory deficits; Neuroprotective; Nootropic; Piracetam; Trachyspermum ammi