title: The effect of basolateral amygdala nucleus lesion on memory under acute,mid and chronic stress in male rats.
abstract: OBJECTIVE
  The basolateral amygdala (BLA) modulates memory for emotional events and is involved in both stress and memory. This study investigated different durations of stress and the role of BLA on serum corticosterone level and spatial and cognitive memory.
  
  
  METHODS
  Different durations of stress (acute, mid, and chronic stress), with and without BLA lesion were induced in rats by 6 h/day restraint stress for 1, 7, and 21 days. Memory functions were evaluated by novel object recognition (NOR) and object location test (OLT).
  
  
  RESULTS
  The OLT findings showed locomotor activity and spatial memory slightly decreased with different durations of stress. The NOR findings significantly showed locomotor activity impairment in different durations of stress. Cognitive memory deficit was observed in mid stress. The corticosterone level significantly increased in the mid and chronic stress groups. Moreover, the mid stress was the strongest stress condition. There is a possibility that different stress durations act by different mechanisms. The recognition of a novel location decreased in all lesion groups. It was more severe in the NOR. The BLA lesion significantly decreased corticosterone level in the mid and chronic stress groups compared to similar groups without lesion.
  
  
  CONCLUSIONS
  The BLA lesion caused more damage to cognitive than spatial memory in stressed groups.
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hoda
authors.initials: H
authors.lastname: Ranjbar
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Radahmadi
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hojjatallah
authors.initials: H
authors.lastname: Alaei
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Parham
authors.initials: P
authors.lastname: Reisi
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Karimi
mesh_terms: D000679:Amygdala; D000818:Animals; D066272:Basolateral Nuclear Complex; D003345:Corticosterone; D008297:Male; D008568:Memory; D008569:Memory Disorders; D051381:Rats; D013315:Stress, Psychological
chemical_list: D003345:Corticosterone
keywords: Basolateral amygdala; corticosterone; memory; novel object recognition; object location test; rat; stress