title: Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis.
abstract: OBJECTIVE
  The role of glucose transporters in cancers remains contradictory. We conducted a systematic review and meta-analysis to assess the association between overall survival and glucose transporter s (GLUTs) 1 and 3 to find an accurate prognostic biomarker.
  
  
  METHODS
  We systematically searched the PubMed, EMbase and Medline databases for relevant published studies that were consistent with the eligible criteria up to January 2016, and calculated pooled estimated hazard ratios of GLUT-1 and -3's expressions in different cancer types and ethnic populations. Random-effects models were used to assess estimates from studies with significant heterogeneities.
  
  
  RESULTS
  Overall, 12 studies concerning GLUT 1 and 2 studies concerning GLUT 3, which involved 2008 participants when combined, were included in this analysis. We found that overexpression of GLUTs were significantly correlated to poorer survival rates (HR=1.63, 95%CI=1.09-2.44 and HR=1.89, 95%CI=1.28-2.81). In the subgroup analysis, the GLUT 1 up-regulation was correlated with negative overall survival in pancreatic cancer and gastric cancer and with better overall survival in colorectal cancer. In addition, overexpression of GLUT 1 was associated with a poorer prognosis in the Asian population, while no significance was found in the non-Asian subgroup. However, limitations do exist, which could be handled better.
  
  
  CONCLUSIONS
  A combination of GLUTs 1 and 3 might help predict malignancy of cancers and direct effective cancer therapy.
authors.affiliation: Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Public Health Nanjing Medical University, Nanjing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Lu
authors.affiliation: The First Clinical School of Nanjing University of Chinese Medicine, Nanjing, China.
authors.forename: Siying
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Xuzhou Medical University, Xuzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhao
authors.affiliation: The First Clinical School of Nanjing University of Chinese Medicine, Nanjing, China.|Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Tang
mesh_terms: D044466:Asian People; D014408:Biomarkers, Tumor / Q000378:metabolism*; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D051274:Glucose Transporter Type 3 / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3
keywords: GLUT; cancer; glucose transporter; meta-analysis; survival