title: Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites.
abstract: A deep-water sponge of the genusSpongosoriteshas yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genusLipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rareN-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistantStaphylococcus aureus,Mycobacterium tuberculosis,Plasmodium falciparum,and a panel of pancreatic cancer cell lines.
authors.affiliation: Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA. awrigh33@fau.edu.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Wright
authors.affiliation: Bruker Biospin Corporation, Billerica, MA 01821, USA. Brian.Killday@bruker.com.
authors.forename: K Brian
authors.initials: KB
authors.lastname: Killday
authors.affiliation: Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA. Debopam.Chakrabarti@ucf.edu.
authors.forename: Debopam
authors.initials: D
authors.lastname: Chakrabarti
authors.affiliation: Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA. eguzman9@fau.edu.
authors.forename: Esther A
authors.initials: EA
authors.lastname: Guzmán
authors.affiliation: Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA. dharmody@hboi.fau.edu.
authors.forename: Dedra
authors.initials: D
authors.lastname: Harmody
authors.affiliation: Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA. pmccart5@fau.edu.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: McCarthy
authors.affiliation: Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA. tpitts3@fau.edu.
authors.forename: Tara
authors.initials: T
authors.lastname: Pitts
authors.affiliation: Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA. spomponi@fau.edu.
authors.forename: Shirley A
authors.initials: SA
authors.lastname: Pomponi
authors.affiliation: Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USA. jreed12@fau.edu.
authors.forename: John K
authors.initials: JK
authors.lastname: Reed
authors.affiliation: Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA. bracken.roberts@knights.ucf.edu.
authors.forename: Bracken F
authors.initials: BF
authors.lastname: Roberts
authors.affiliation: Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA. carolinarodriguesfelix@knights.ucf.edu.
authors.forename: Carolina
authors.initials: C
authors.lastname: Rodrigues Felix
authors.affiliation: Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA. Kyle.Rohde@ucf.edu.
authors.forename: Kyle H
authors.initials: KH
authors.lastname: Rohde
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology; D012623:Seawater
chemical_list: D026121:Indole Alkaloids; D011719:Pyrazines
keywords: Spongosorites; antibacterial; bis(indole) alkaloid; pancreatic cancer