title: miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2.
abstract: Novel targeted therapies need to be developed for gastric cancer, the third most common cancer type and the second most common cause of cancer-related mortality in China. Previous studies indicate that angiopoietin (Ang)-2 serves a role in the proliferation, migration, invasion and adhesion of malignant cells. The present study identified, using functional studies, that exogenous expression of miR-218 increased migration of NCI-87 and HGC-27 gastric cancer cells, which coincided with a reduction in the expression of Ang-2. In addition, intratumoral delivery of miR-218 inhibited proliferation and angiogenesis of gastric cancer cellsin vivo, with a corresponding decreased in Ang-2 expression. These results indicate that miR-218 serves an important role in gastric cancer tumorigenesis through regulating the expression of Ang-2. Therefore, components of miR-218/Ang-2 signaling could provide novel therapeutic targets for the treatment of gastric cancer.
authors.affiliation: Department of Gastrointestinal Surgery, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China; Department of General Surgery, Laiwu People's Hospital, Laiwu, Shandong 271100, P.R. China.
authors.forename: Sifeng
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of General Surgery, Laiwu People's Hospital, Laiwu, Shandong 271100, P.R. China.
authors.forename: Deyou
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Laiwu People's Hospital, Laiwu, Shandong 271100, P.R. China.
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal Surgery, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China; Department of General Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors.forename: Leping
authors.initials: L
authors.lastname: Li
keywords: angiogenesis; angiopoietin-2; gastric cancer; miR-218; proliferation