title: [Ocular graft-versus-host disease: An often misdiagnosed etiology of dry eye syndrome].
abstract: OBJECTIVE
  To report a case of severe ocular graft-versus-host disease (GVHD) after cataract surgery.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  We describe the case of a 59-year-old man with postoperative corneal ulcer on his only functional eye. His past history reported allogenic bone marrow transplant. His visual acuity (VA) was limited to hand motions. Slit lamp examination revealed diffuse conjunctival hyperemia, severe blepharitis, Meibomian dysfunction, total corneal opacification with epithelial and stromal keratitis and neovascular invasion. Because of the severe dry eye symptoms and history of allogenic hematological stem cell transplantation, ocular GVHD was diagnosed. Functional and anatomical improvement occurred rapidly with topical cyclosporine 2%, with improved VA after treatment.
  
  
  CONCLUSIONS
  With any severe dry eye syndrome in the context of allogenic bone marrow transplant, ocular GVHD must be considered. For planned ocular surgery, we recommend adding cyclosporine 0.1% treatment before and after surgery to prevent severe ocular GVHD.
authors.affiliation: Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. Electronic address: lauramoyal@yahoo.fr.
authors.forename: L
authors.initials: L
authors.lastname: Moyal
authors.affiliation: Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Adam
authors.affiliation: Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Akesbi
authors.affiliation: Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
authors.forename: F T
authors.initials: FT
authors.lastname: Rodallec
authors.affiliation: Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Nordmann
mesh_terms: D001762:Blepharitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D016572:Cyclosporine / Q000627:therapeutic use; D003951:Diagnostic Errors; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D006086:Graft vs Host Disease / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016572:Cyclosporine
keywords: Ciclosporine topique; Dry eye; Ocular graft-versus-host disease; Réaction oculaire du greffon contre l’hôte; Syndrome sec; Topical cyclosporine: Prophyllactic treatment; Traitement préventif