title: Spectroscopic Physicochemical and Photophysical Investigation of Biologically Active 2-oxo-quinoline-3-carbonitrile Derivative.
abstract: 4-(2,3,4-trimethoxyphenyl)-8-methoxy-2-oxo-1,2,5,6 tetrahydrobenzo [h] quinoline-3-carbonitrile (TMTQ) dye was synthesized by one-pot multicomponent reactions (MCRs) of 2,3,4 trimethoxybenzaldehyd, ethyl cyanoacetate, 6-methoxy-1,2,3,4-tetrahydro-naphthalin-1-one and ammonium acetate under microwave irradiation. The structures of the synthesized compound was established by spectroscopic (FT-IR,1H-NMR,13C-NMR, EI-MS) and elemental analysis. In addition, spectroscopic and physicochemical parameters, including electronic absorption, excitation coefficient, Stokes shift, oscillator strength, transition dipole moment and fluorescence quantum yield have investigated in order to explore the analytical potential of synthesized compounds. TMTQ dye undergoes solubilization in different micelles and may be used as a probe and quencher to determine the critical micelle concentration (CMC) of CTAB and SDS. In addition we extent of TMTQ anti-bacterial properties TMTQ was first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug Tetracycline.
authors.affiliation: Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia. mohiem@yahoo.com.
authors.forename: Mohie E M
authors.initials: ME
authors.lastname: Zayed
authors.affiliation: DAV College, NIT-3, Faridabad, 121001, Haryana, India.
authors.forename: Parveen
authors.initials: P
authors.lastname: Kumar
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009570:Nitriles / Q000737:chemistry* / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005456:Fluorescent Dyes; D009570:Nitriles; D011804:Quinolines; D013752:Tetracycline
keywords: Antibacterial activity; CMC; One pot; Physicochemical; TMTQ