title: Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation.
abstract: Neoplastic cells often reside in distinctive tumor hypoxia armed with a series of adaptive responses including oxidative stress, defective apoptotic machinery and neoangiogenesis, through that further confer cell survival improvement. Plants still acts as reservoir of natural chemicals to provide newer active pharmacophores. Scutellarein is flavones which has wide range of pharmacophoral effects. In our current research, scutellarein employed for targeting oxidative stress mediated tumor angiogenesis and apoptotic nuclear fragmentation. Experimental results revealed that scutellarein has antiproliferative index against multiple cancer cell lines and diminished the oxidative stress and tumor development of murine ascitic lymphoma & inflammatory hepatocellular carcinoma. Eventual consequences lead to reduced neovessel formation by abrogating angiogeneic factors cytokine-VEGF-A, Flt-1, HIF-1α, MMP-2 and MMP-9 and reversing of evading apoptosis by activating caspase-3 activated DNA fragmentation factor (DFF-40) mediated nucleosomal degradation. In summary, our experimental evidences suggest that scutellarein has strong potentiality to attenuate the tumor development by modulating sprouting neovasculature and DFF-40 mediated apoptosis.
authors.affiliation: Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, 577 203, Karnataka, India.
authors.forename: Prabhu
authors.initials: P
authors.lastname: Thirusangu
authors.affiliation: Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, 577 203, Karnataka, India.
authors.forename: V
authors.initials: V
authors.lastname: Vigneshwaran
authors.affiliation: Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, 577 203, Karnataka, India; Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Vijay Avin
authors.affiliation: Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, 577 203, Karnataka, India.
authors.forename: H
authors.initials: H
authors.lastname: Rakesh
authors.affiliation: Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, 577 203, Karnataka, India.
authors.forename: H M
authors.initials: HM
authors.lastname: Vikas
authors.affiliation: Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, 577 203, Karnataka, India. Electronic address: pbtssc@gmail.com.
authors.forename: B T
authors.initials: BT
authors.lastname: Prabhakar
mesh_terms: D000818:Animals; D047310:Apigenin / Q000494:pharmacology*; D063646:Carcinogenesis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003851:Deoxyribonucleases / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000139:chemically induced*; D009707:Nucleosomes / Q000378:metabolism*; D051381:Rats; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology*
chemical_list: D009707:Nucleosomes; D042461:Vascular Endothelial Growth Factor A; D047310:Apigenin; D003851:Deoxyribonucleases; C458179:scutellarein
keywords: Antiangiogenesis; Apoptosis; Cancer; Oxidative stress; Scutellarein