title: The Anti-Aging Effects of Low Oxygen Tension Generated Multipotent Growth Factor Containing Serum.
abstract: Growth factors are a new category of ingredient found in modern cosmeceutical formulations. One novel method of obtaining cosmeceutical growth factors is the use of a bioreactor to culture neonatal broblasts on dextran microcarrier beads for 8 weeks under low oxygen tension (1-5%) mimicking embryonic conditions and eliminating the need for fetal bovine serum constituents in the final cosmetic material. This research evaluated the ingredient in a moisturizing vehicle on 40 females to determine its efficacy in improving overall facial skin appearance, as well as skin brightness, evenness, firmness, pore size, radiance, fine lines, coarse wrinkles, and blotchiness/ dispigmentation. Statistically significant improvement was seen in 90 days in skin hydration through corneometry, as well in global investigator and subject assessments. <em>J Drugs Dermatol. 2017;16(1):30-34.</em>.
authors.forename: Zoe Diana
authors.initials: ZD
authors.lastname: Draelos
authors.forename: Jwala
authors.initials: J
authors.lastname: Karnik
authors.forename: Gail
authors.initials: G
authors.lastname: Naughton
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D005260:Female; D051523:Fibroblast Growth Factor 7 / Q000008:administration & dosage* / Q000302:isolation & purification; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000302:isolation & purification; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage*; D015595:Skin Aging / Q000187:drug effects* / Q000502:physiology*; D063465:Skin Cream / Q000008:administration & dosage* / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D051523:Fibroblast Growth Factor 7; D010100:Oxygen