title: IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease.
abstract: There are many IL1RL1 single nucleotide polymorphisms (SNP) significantly associated with circulating sST2 concentration. Little is known about the effects of IL1RL1 SNP on the outcome of cardiovascular disease. The aim of this study is to investigate whether IL1RL1 SNP can predict mortality.
  
  
  
  We enrolled 601 individuals receiving health examination, 532 patients with coronary artery disease (CAD), and 86 patients with peripheral artery disease (PAD). Genotyping for SNP rs950880 and rs13001325 was performed and sST2 level was measured. The primary endpoint was all-cause death. The secondary endpoints were cardiovascular death, myocardial infarction, hospitalization for heart failure, stroke, and amputation.
  
  
  
  Individuals having rs950880 AA genotype all had rs13001325 TT genotype and tended to have lower sST2 levels in all 3 populations. Kaplan-Meier survival curves showed that patients with high sST2 level and rs950880 AA genotype had the lowest survival rate in presence of CAD (p < 0.001) and PAD (p = 0.007). In multivariable Cox regression analysis, the independent predictors of all-cause death were rs950880 AA homozygote (p = 0.018), age (p = 0.002), log sST2 level (p = 0.014), and log GDF-15 level (p = 0.017) in CAD patients. The independent predictor of all-cause death was rs950880-AA homozygote (p = 0.019) in PAD patients. There was no significant difference in secondary endpoints between rs950880 AA homozygote and C allele carriers.
  
  
  
  Individuals having rs950880 AA genotype also have rs13001325 TT genotype and tend to have lower sST2 levels. The rs950880 AA homozygote is an independent predictor of all-cause mortality in CAD and PAD patients.
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Jeng-Feng
authors.initials: JF
authors.lastname: Lin
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; Department of Life Science, Chinese Culture University, Taipei, Taiwan.
authors.forename: Semon
authors.initials: S
authors.lastname: Wu
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
authors.forename: Jyh-Ming Jimmy
authors.initials: JJ
authors.lastname: Juang
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
authors.forename: Fu-Tien
authors.initials: FT
authors.lastname: Chiang
authors.affiliation: First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Lung-An
authors.initials: LA
authors.lastname: Hsu
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Teng
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
authors.forename: Shih-Tsung
authors.initials: ST
authors.lastname: Cheng
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
authors.forename: Hsuan-Li
authors.initials: HL
authors.lastname: Huang
authors.affiliation: Department of Laboratory Medicine, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Sun
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Liu
authors.affiliation: Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address: yulinkotw@yahoo.com.tw.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Ko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics* / Q000401:mortality; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000097:blood* / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D058729:Peripheral Arterial Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics* / Q000401:mortality; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D005819:Genetic Markers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein
keywords: Coronary artery disease; IL1RL1; Peripheral artery disease; ST2; Single nucleotide polymorphism