title: Effect of thymectomy for thymic atrophy in myasthenia gravis: A retrospective study on 93 patients.
abstract: To clarify the efficacy of thymectomy among myasthenia gravis (MG) patients with and without thymoma. We classified MG patients who underwent thymectomy into 3 groups, such as thymic atrophy group, thymic follicular hyperplasia (TFH) group and thymoma group. We compared the data of clinical features and postoperative prognosis at very short-term, short-term, and medium-term. The clinical course of MG patients with atrophic thymus after thymectomy was even better than those of TFH or thymoma, in this retrospective study. However, we found no significant differences in the comparison of mean dose of prednisolone between the 3 groups at each time point.
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: 97056kn@gmail.com.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nakahara
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Molecular Neurology and Therapeutics, Kumamoto University Hospital, Kumamoto, Japan. Electronic address: nakaneshunya@gmail.com.
authors.forename: Shunya
authors.initials: S
authors.lastname: Nakane
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: nakazima04@gmail.com.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: yamashitasatosi@fc.kuh.kumamoto-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: morimori@fc.kuh.kumamoto-u.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: andoy709@kumamoto-u.ac.jp.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood; D001284:Atrophy / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000601:surgery*; D011183:Postoperative Complications / Q000473:pathology / Q000503:physiopathology*; D011863:Radioimmunoassay; D011950:Receptors, Cholinergic / Q000276:immunology; D012189:Retrospective Studies; D013934:Thymectomy / Q000009:adverse effects*; D013945:Thymoma / Q000601:surgery; D013950:Thymus Gland / Q000473:pathology*; D013952:Thymus Hyperplasia / Q000601:surgery; D013953:Thymus Neoplasms / Q000601:surgery
chemical_list: D000906:Antibodies; D011950:Receptors, Cholinergic
keywords: Anti-acetylcholine receptor antibody; Myasthenia gravis; Prednisolone; Thymectomy; Thymus pathology