title: Satb1: Restraining PD1 and T Cell Exhaustion.
abstract: Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.
authors.affiliation: Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
authors.forename: Briana G
authors.initials: BG
authors.lastname: Nixon
authors.affiliation: Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: lim@mskcc.org.
authors.forename: Ming O
authors.initials: MO
authors.lastname: Li
mesh_terms: D016678:Genome; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics*; D013601:T-Lymphocytes
chemical_list: D036961:Matrix Attachment Region Binding Proteins