title: Acute Anterior Uveitis in a Patient Taking Fingolimod (FTY720) for Multiple Sclerosis.
abstract: Fingolimod is an oral sphingosine-1-phosphate (S1P) receptor modulator and the first oral therapy for relapsing-remitting multiple sclerosis. Its use has been complicated by a low rate of cystoid macular edema usually in the first 3 months after commencement of the medication. We report the case of a 34-year-old male with relapsing-remitting multiple sclerosis, who developed acute anterior uveitis on day 5 of fingolimod treatment. He responded to appropriate treatment and cessation of drug, but developed low-grade chronic anterior uveitis without cystoid macular edema. We discuss possible mechanisms of uveitis onset in this group of patients. Urgent ophthalmological review is recommended for patients receiving fingolimod therapy who develop a red, painful eye, which may occur within 5 days of fingolimod treatment initiation.
authors.affiliation: Cabrini Medical Centre, Malvern, VIC, Australia; Melbourne Health, Parkville, VIC, Australia; Department of Surgery, University of Melbourne, Parkville, VIC, Australia; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
authors.forename: Heather Gwen
authors.initials: HG
authors.lastname: Mack
authors.affiliation: National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: Melissa Chih-Hui
authors.initials: MC
authors.lastname: Tien
authors.affiliation: Cabrini Medical Centre, Malvern, VIC, Australia; Melbourne Health, Parkville, VIC, Australia.
authors.forename: Owen Bruce
authors.initials: OB
authors.lastname: White
keywords: FTY720; Fingolimod; Rebound syndrome; Relapsing-remitting multiple sclerosis; Uveitis