title: Intraluminal laser speckle rheology using an omni-directional viewing catheter.
abstract: A number of disease conditions in luminal organs are associated with alterations in tissue mechanical properties. Here, we report a new omni-directional viewing Laser Speckle Rheology (LSR) catheter for mapping the mechanical properties of luminal organs without the need for rotational motion. The LSR catheter incorporates multiple illumination fibers, an optical fiber bundle and a multi-faceted mirror to permit omni-directional viewing of the luminal wall. By retracting the catheter using a motor-drive assembly, cylindrical maps of tissue mechanical properties are reconstructed. Evaluation conducted in a test phantom with circumferentially-varying mechanical properties demonstrates the capability of the LSR catheter for the accurate mechanical assessment of luminal organs.
authors.affiliation: Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, MA 02114, USA; Authors contributed equally to this work.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, MA 02114, USA; Healthcare Optics Research Laboratory, Canon U.S.A., Inc., Cambridge, MA 02139, USA; Authors contributed equally to this work.
authors.forename: Masaki
authors.initials: M
authors.lastname: Hosoda
authors.affiliation: Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, MA 02114, USA.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Tshikudi
authors.affiliation: Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, MA 02114, USA.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Hajjarian
authors.affiliation: Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, MA 02114, USA.
authors.forename: Seemantini K
authors.initials: SK
authors.lastname: Nadkarni
keywords: (030.6140) Speckle; (170.2150) Endoscopic imaging; (170.4580) Optical diagnostics for medicine; (290.1990) Diffusion; (290.4210) Multiple scattering