title: The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment.
abstract: A benefit of anti-angiogenic drugs is improved tumor immune tolerance. Regulatory T cells (Tregs) in the tumor microenvironment mediate tumor immune tolerance and anti-angiogenic drugs not only indirectly affect Tregs via dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) but they can also act directly on Tregs causing immunosuppression. Specifically, these drugs may induce differentiation and chemotaxis and reduce the number and function of Tregs by targeting vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) on the cell surface. Recently, anti-angiogenic drugs have been documented to promote a new way of thinking about tumor immunotherapy: clinical application of Tregs and related immunosuppressive molecules may be promising targets for synergistic tumor immunotherapy.
authors.affiliation: Tumor laboratory, Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University. No. 182, Tongguan Road, Lianyungang City 222002, Jiangsu Province, China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Hu
authors.affiliation: Tumor laboratory, Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University. No. 182, Tongguan Road, Lianyungang City 222002, Jiangsu Province, China. Electronic address: jxdysy1970@163.com.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Jiang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D018655:Lymphocyte Count; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*; D059016:Tumor Microenvironment / Q000187:drug effects / Q000276:immunology*
chemical_list: D020533:Angiogenesis Inhibitors
keywords: Anti-angiogenics; Regulatory T cells; Tumor microenvironment