title: The assessment of macular electrophysiology and macular morphology in patients with vitiligo.
abstract: OBJECTIVE
  We aimed to analyze the electrophysiologic function and morphology of macula in vitiligo patients.
  
  
  METHODS
  Seventeen patients with vitiligo and 11 healthy subjects were studied. All participants underwent multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT) evaluations. The mfERG (P1 mfERG responses central and peripheral) and retinal layer segmentation parameters (nine ETDRS subfields) were compared in vitiligo and control groups.
  
  
  RESULTS
  The mean P1 response amplitudes were significantly decreased in central and peripheral rings of the fovea in patients with vitiligo compared with controls (p = 0.002 and p = 0.006, respectively). There was a tendency toward a prolonged mean implicit time for both central and peripheral in patients with vitiligo compared to controls, however, with no statistical significance (p = 0.453 and p = 0.05, respectively). There was no statistically significant difference in all retinal layers thickness between two groups.
  
  
  CONCLUSIONS
  In patients with vitiligo, while photoreceptor segment preserved in SD-OCT, mfERG reduced showing potential decline in central retinal function. This study showed a potential decline in central retinal function in patients with vitiligo even if they have normal fundus appearance and SD-OCT findings.
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, TEM Avrupa Otoyolu Cıkısı, 34214, Bagcılar, Istanbul, Turkey. drrukiyeaydin@gmail.com.
authors.forename: Rukiye
authors.initials: R
authors.lastname: Aydin
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, TEM Avrupa Otoyolu Cıkısı, 34214, Bagcılar, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozsutcu
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, TEM Avrupa Otoyolu Cıkısı, 34214, Bagcılar, Istanbul, Turkey.
authors.forename: Sevil Karaman
authors.initials: SK
authors.lastname: Erdur
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, TEM Avrupa Otoyolu Cıkısı, 34214, Bagcılar, Istanbul, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Dikkaya
authors.affiliation: Department of Dermatology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Balevi
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, TEM Avrupa Otoyolu Cıkısı, 34214, Bagcılar, Istanbul, Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Ozbek
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, TEM Avrupa Otoyolu Cıkısı, 34214, Bagcılar, Istanbul, Turkey.
authors.forename: Fevzi
authors.initials: F
authors.lastname: Senturk
mesh_terms: D000293:Adolescent; D000328:Adult; D004596:Electroretinography / Q000379:methods*; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D009887:Ophthalmoscopy; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity; D014820:Vitiligo / Q000175:diagnosis / Q000503:physiopathology*; D055815:Young Adult
keywords: Multifocal electroretinography; Photoreceptor function; Spectral domain optical coherence tomography; Vitiligo