title: Impact of reactive oxygen species generation on Helicobacter pylori-related extragastric diseases: a hypothesis.
abstract: Helicobacter pylori (H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety of H. pylori-related gastric diseases, as shown in animal and human studies. Helicobacter pylori infection is also associated with variety of systemic extragastric diseases in which H. pylori-related ROS production might also be involved in the pathogenesis of these systemic conditions. We proposed that Hp-related ROS may play a crucial role in the pathophysiology of Hp-related systemic diseases including Alzheimer's disease, multiple sclerosis, glaucoma and other relative neurodegenerative diseases, thereby suggesting introduction of relative ROS scavengers as therapeutic strategies against these diseases which are among the leading causes of disability and are associated with a large public health global burden. Moreover, we postulated that H. pylori-related ROS might also be involved in the pathogenesis of extragastric common malignancies, thereby suggesting that H. pylori eradication might inhibit the development or delay the progression of aforementioned diseases. However, large-scale future studies are warranted to elucidate the proposed pathophysiological mechanisms, including H. pylori-related ROS, involved in H. pylori-associated systemic and malignant conditions.
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Jannis
authors.initials: J
authors.lastname: Kountouras
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Marina
authors.initials: M
authors.lastname: Boziki
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Stergios A
authors.initials: SA
authors.lastname: Polyzos
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Katsinelos
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Emmanouel
authors.initials: E
authors.lastname: Gavalas
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Zeglinas
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Tzivras
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Iordanis
authors.initials: I
authors.lastname: Romiopoulos
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Giorgakis
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Anastasiadou
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Vardaka
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Kountouras
authors.affiliation: a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Kazakos
authors.affiliation: b Department of Neurology , Multiple Sclerosis Unit, Papageorgiou General Hospital , Thessaloniki , Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Xiromerisiou
authors.affiliation: c Laboratory of Neurogenetics, Department of Neurology , University of Thessaly, University Hospital of Larissa , Greece.
authors.forename: Efthimios
authors.initials: E
authors.lastname: Dardiotis
authors.affiliation: b Department of Neurology , Multiple Sclerosis Unit, Papageorgiou General Hospital , Thessaloniki , Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Deretzi
mesh_terms: D000818:Animals; D016481:Helicobacter Infections / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D019636:Neurodegenerative Diseases / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species
keywords: Helicobacter pylori; Reactive oxygen species; inflammation; neurodegenerative diseases; neuroinflammation