title: Caenorhabditis elegans as a model to study the impact of exposure to light emitting diode (LED) domestic lighting.
abstract: This study aimed to investigate the biological impact of exposure on domestic light emitting diodes (LED) lighting using the free-living nematode Caenorhabditis elegans as a model. Nematodes were separately exposed to white LED light covering the range of 380-750 nm, blue light at 450 nm and black light at 380-420 nm for one life cycle (egg to adult) with dark exposure as the control. Each light range induced stress to the nematode C. elegans such as reducing the number of the hatched eggs and/or delayed the maturation of the hatched eggs to the adult stage. In addition, it lowered or prevented the ability of adults to lay eggs and impaired the locomotion in the exposed worms. The observed type of biological stress was also associated with the production of reactive oxygen species (ROS) as compared to nematodes grown in the dark. It is concluded that the blue light component of white LED light may cause health problems, and further investigation is required to test commercial brands of white LEDs that emit different amounts of blue light.
authors.affiliation: a Department of Biology , Texas Southern University , Houston , Texas , USA.
authors.forename: Fawzia
authors.initials: F
authors.lastname: Abdel-Rahman
authors.affiliation: a Department of Biology , Texas Southern University , Houston , Texas , USA.
authors.forename: Bethel
authors.initials: B
authors.lastname: Okeremgbo
authors.affiliation: a Department of Biology , Texas Southern University , Houston , Texas , USA.
authors.forename: Fatimah
authors.initials: F
authors.lastname: Alhamadah
authors.affiliation: a Department of Biology , Texas Southern University , Houston , Texas , USA.
authors.forename: Sakha
authors.initials: S
authors.lastname: Jamadar
authors.affiliation: b Department of Chemistry , Texas Southern University , Houston , Texas , USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Anthony
authors.affiliation: b Department of Chemistry , Texas Southern University , Houston , Texas , USA.
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: Saleh
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000254:growth & development / Q000378:metabolism / Q000528:radiation effects*; D004781:Environmental Exposure / Q000032:analysis*; D048788:Growth and Development / Q000528:radiation effects; D007814:Larva / Q000254:growth & development / Q000528:radiation effects; D008027:Light; D008029:Lighting; D008962:Models, Theoretical; D018384:Oxidative Stress / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species
keywords: Biophotonics; ROS: toxicity; egg hatching: LED; locomotion; oxidative damage; progeny