title: Angiosarcoma in HIV-negative patients is not associated with HHV-8.
abstract: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.
  To investigate the relationship between the presence of HHV-8 and angiosarcoma.
  In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.
  While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.
  These findings support most previous studies that found no association between HHV-8 and angiosarcoma.
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Avancini
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Sanches
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: Andre Pires Zanata
authors.initials: AP
authors.lastname: Cherubim
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Pazzini
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: Cristina Mendes de
authors.initials: CM
authors.lastname: Oliveira
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: Laura Masami
authors.initials: LM
authors.lastname: Sumita
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: Neusa Yuriko Sakai
authors.initials: NY
authors.lastname: Valente
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: Claudio Sergio
authors.initials: CS
authors.lastname: Pannuti
authors.affiliation: Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
authors.forename: Cyro
authors.initials: C
authors.lastname: Festa
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000473:pathology / Q000821:virology*; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D004279:DNA, Viral; D005260:Female; D015658:HIV Infections / Q000821:virology; D018023:HIV Seronegativity; D006394:Hemangiosarcoma / Q000473:pathology / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000473:pathology / Q000821:virology*; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*; D055544:beta-Globins / Q000032:analysis
chemical_list: D004279:DNA, Viral; D055544:beta-Globins