title: Neuroblastoma in a Child With Wolf-Hirschhorn Syndrome.
abstract: Neuroblastoma is the most common extracranial solid tumor of childhood originating from sympathetic nervous system cells. Neuroblastoma has also been diagnosed in conjunction with other congenital conditions such as Hirschsprung's disease, congenital hypoventilation disorder, and neurofibromatosis type 1. Wolf-Hirschhorn syndrome is a congenital disorder caused by microdeletion of short arm of chromosome 4 encoding MSX1 gene with characteristic facial features. We describe a child with dysmorphic features, developmental delay, mental retardation who developed neuroblastoma at 2 years of age and cytogenetic analysis of blood lymphocytes revealed an interstitial deletion of 4p(15,2). To best our knowledge, this report is the first report of neuroblastoma in a child with Wolf-Hirschhorn syndrome; and the reported association may be an important clue for oncological follow-up of patients with Wolf-Hirschhorn syndrome.
authors.affiliation: *Department of Pediatrics, Division of Pediatric Hematology Oncology †Department of Pediatrics, Division of Pediatric Neurology ‡Department of Radiology, Divison of Interventional Radiology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Ozcan
authors.forename: Hamit
authors.initials: H
authors.lastname: Acer
authors.forename: Saliha
authors.initials: S
authors.lastname: Ciraci
authors.forename: Hakan
authors.initials: H
authors.lastname: Gumus
authors.forename: Musa
authors.initials: M
authors.lastname: Karakukcu
authors.forename: Turkan
authors.initials: T
authors.lastname: Patiroglu
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Ozdemir
authors.forename: Ekrem
authors.initials: E
authors.lastname: Unal
mesh_terms: D002675:Child, Preschool; D002872:Chromosome Deletion; D002894:Chromosomes, Human, Pair 4; D002658:Developmental Disabilities; D006801:Humans; D008607:Intellectual Disability; D009447:Neuroblastoma / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D054877:Wolf-Hirschhorn Syndrome / Q000150:complications*