title: Open chromatin profiling as a novel strategy for identifying cancer cell of origin.
abstract: Tumor cell of origin is an important prognostic measure but is challenging to assess. We recently demonstrated in acute myeloid leukemia (AML) that the chromatin landscape serves as a biomarker of transformed cell of origin. Thus, open chromatin loci offer important prognostic information as well as targets for development of novel therapies in cancer treatment.
authors.affiliation: The Jackson Laboratory , Bar Harbor, ME, USA.
authors.forename: Kira
authors.initials: K
authors.lastname: Young
authors.affiliation: The Jackson Laboratory , Bar Harbor, ME, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Trowbridge
keywords: Acute myeloid leukemia; biomarker; chromatin; progenitor cell; stem cell