title: Toward the Atomic Structure of PrPSc.
abstract: In this review, we detail our current knowledge of PrPScstructure on the basis of structural and computational studies. We discuss the progress toward an atomic resolution description of PrPScand results from the broader field of amyloid studies that may further inform our knowledge of this structure. Moreover, we summarize work that investigates the role of PrPScstructure in its toxicity, transmissibility, and species specificity. We look forward to an atomic model of PrPSc, which is expected to bring diagnostics and/or therapeutics to the field of prion disease.
authors.affiliation: Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California 90095.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Rodriguez
authors.affiliation: Department of Neurology, Molecular Biology Institute (MBI), and Brain Research Institute (BRI), David Geffen School of Medicine, University of California, Los Angeles, California 90095.
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Biological Chemistry, UCLA-DOE Institute for Genomics and Proteomics, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
authors.forename: David S
authors.initials: DS
authors.lastname: Eisenberg
mesh_terms: D058227:Amyloidogenic Proteins / Q000737:chemistry; D005656:Fungal Proteins / Q000737:chemistry; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D018620:PrPSc Proteins / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein; D013045:Species Specificity
chemical_list: D058227:Amyloidogenic Proteins; D005656:Fungal Proteins; D018620:PrPSc Proteins