title: THE RETINOBLASTOMA PROTEIN: A MASTER TUMOR SUPPRESSOR ACTS AS A LINK BETWEEN CELL CYCLE AND CELL ADHESION.
abstract: RB1was the first tumor suppressor gene discovered. Over four decades of work have revealed that the Rb protein (pRb) is a master regulator of biological pathways influencing virtually every aspect of intrinsic cell fate including cell growth, cell-cycle checkpoints, differentiation, senescence, self-renewal, replication, genomic stability and apoptosis. While these many processes may account for a significant portion ofRB1's potency as a tumor suppressor, a small, but growing stream of evidence suggests thatRB1also significantly influences how a cell interacts with its environment, including cell-to-cell and cell-to-extracellular matrix interactions. This review will highlight pRb's role in the control of cell adhesion and how alterations in the adhesive properties of tumor cells may drive the deadly process of metastasis.
authors.affiliation: Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Engel
authors.affiliation: Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: W D
authors.initials: WD
authors.lastname: Cress
authors.affiliation: Department of Biochemistry, Ponce School of Medicine, Ponce, PR, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Santiago-Cardona
keywords: Adhesion; Cadherin; Cell cycle; Integrin; Retinoblastoma; pRb