title: Effect of New Antiviral Agent Camphecin on Behavior of Mice.
abstract: We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions). The findings are discussed in the context of neutral influence of camphecin on animal behavior.
authors.affiliation: Novosibirsk National Research State University, Novosibirsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Babina
authors.affiliation: Novosibirsk National Research State University, Novosibirsk, Russia. igor@academ.org.
authors.forename: V A
authors.initials: VA
authors.lastname: Lavrinenko
authors.affiliation: Novosibirsk National Research State University, Novosibirsk, Russia.|N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Yarovaya
authors.affiliation: Novosibirsk National Research State University, Novosibirsk, Russia.|N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: N F
authors.initials: NF
authors.lastname: Salakhutdinov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001007:Anxiety; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D004983:Ethanolamines / Q000138:chemical synthesis / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology
chemical_list: D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D004983:Ethanolamines
keywords: anxiety; camphecin; locomotor activity