title: Nephrectomy-induced reduced renal function and the health-related quality of life of living kidney donors.
abstract: To evaluate the health impact of nephrectomy on living kidney donors (LKDs) by comparing the health-related quality of life (HrQOL) scores measured by Short Form-36 (SF36) between those with and without postdonation renal function impairment (PRFI).
  
  
  
  Eighty-two LKDs (47 females, mean age=50.2±11.2 years) were prospectively recruited to participate in a SF-36 HrQOL survey. Chart review, individual baseline, and postoperative renal function (eGFR) was determined using the Modification of Diet in Renal Disease formula. PRFI was defined as eGFR<60 mL/min/1.73 m2or proteinuria. Mean SF-36 domain scores were compared between those with and without PRFI.
  
  
  
  After a median follow-up of 5.7 years, the prevalence of postdonation comorbidities was 29.3% (n=24) PRFI, 25.6% (n=21) hypertension, 6.1% (n=5) diabetes, and 3.7% (n=3) heart disease, and no LKDs developed end-stage renal disease. Mean eGFR before and after donor nephrectomy was 95.5±23.4 and 71.0±17.3 mL/min/1.73 m2(P<.01). Mean SF-36 scores of LKDs were not significantly different between those with and without PRFI in all the domains (all P>.05). Similarly, the proportion of LKDs with PRFI did not differ significantly between the patients with SF-36 domain scores above and below the published reference values.
  
  
  
  Nephrectomy-induced PRFI may not have a significant impact on the HrQOL of the LKD population with a low proportion of other major comorbidities such as diabetes and ischemic heart disease.
authors.affiliation: Department of Urology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Xiao
authors.identifier: 0000-0001-8055-9987
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Urology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Joel Yu Ming
authors.initials: JY
authors.lastname: Lim
authors.affiliation: Department of Urology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Lata
authors.initials: L
authors.lastname: Raman
authors.affiliation: Saw Swee Hock School of Public Health, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Bee Choo
authors.initials: BC
authors.lastname: Tai
authors.affiliation: Department of Nephrology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Hersharan
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Department of Nephrology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Angeline Ting Hui
authors.initials: AT
authors.lastname: Goh
authors.affiliation: Department of Nephrology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Anantharaman
authors.initials: A
authors.lastname: Vathsala
authors.affiliation: Department of Urology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Ho Yee
authors.initials: HY
authors.lastname: Tiong
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D011184:Postoperative Period; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D051437:Renal Insufficiency / Q000209:etiology*; D012307:Risk Factors; D020858:Tissue and Organ Harvesting
keywords: chronic kidney disease; kidney transplantation; nephrectomy