title: Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs.
abstract: Infectious bursal disease (IBD) is an acute, highly contagious and immunosuppressive poultry disease caused by IBD virus (IBDV). The consequent immunosuppression increases susceptibility to other infectious diseases and the risk of subsequent vaccination failure as well. Since the genome of IBDV is relatively small, it has a limited number of proteins inhibiting the cellular antiviral responses and acting as destroyers to the host defense system. Thus, these virulence factors must be multifunctional in order to complete the viral replication cycle in a host cell. Insights into the roles of these viral proteins along with their multiple cellular targets in different pathways will give rise to a rational design for safer and effective vaccines. Here we summarize the recent findings that focus on the virus-cell interactions during IBDV infection at the protein level.
authors.affiliation: State Key Laboratory of Agrobiotechnology, Beijing 100193, China. qyao_cau@163.com.|Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, Beijing 100193, China. qyao_cau@163.com.|College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. qyao_cau@163.com.
authors.forename: Yao
authors.initials: Y
authors.lastname: Qin
authors.affiliation: State Key Laboratory of Agrobiotechnology, Beijing 100193, China. sjzheng@cau.edu.cn.|Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, Beijing 100193, China. sjzheng@cau.edu.cn.|College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. sjzheng@cau.edu.cn.
authors.forename: Shijun J
authors.initials: SJ
authors.lastname: Zheng
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D007165:Immunosuppression Therapy; D007243:Infectious bursal disease virus / Q000502:physiology*; D011991:Receptors, Virus / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: D011991:Receptors, Virus; D014764:Viral Proteins
keywords: cellular target; immunosuppression; infectious bursal disease virus (IBDV)