title: Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer.
abstract: Oxidative stress is involved in a variety of diseases. Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant/antioxidant status and CRC. Therefore, we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects, and analyzed their clinical significance in the CRC. Fasting blood samples from 132 CRC patients and 64 healthy subjects were collected. Oxidative stress parameters, including total oxidant status (TOS) and total antioxidant status (TAS), were measured, and the oxidative stress index (OSI) was calculated. The TOS and OSI levels increased significantly (P<0.001) and the TAS level significantly decreased (P<0.001) in the CRC group compared to those in the healthy control group. Oxidative stress parameters differed significantly depending on the patient's smoking and drinking status (P<0.05). The preoperative and postoperative levels of TOS, TAS, and OSI did not differ significantly between primary sites (colon/rectum) and clinical stages (P>0.05).However, the levels of TOS, TAS, and OSI were significantly different between patients with no metastasis and those with metastases to two organs (P<0.05) Finally, the parameters are affected by smoking and drinking, and subsequent research should be conducted excluding the relevant influencing factors.
authors.affiliation: Department of Oncology, MianYang Central Hospital, Sichuan, People's Republic of China.|Department of Surgery, Southwest Medical University, Sichuan, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
authors.affiliation: Department of Clinical Laboratory, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Jiafu
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Clinical Laboratory, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Clinical Laboratory, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Dai
authors.affiliation: Emergency Department, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Anyang
authors.initials: A
authors.lastname: Lu
authors.affiliation: Department of Oncology, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oncology, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Department of Oncology, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Xiang
authors.affiliation: Department of Oncology, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Surgery, Southwest Medical University, Sichuan, People's Republic of China.|Department of Surgery, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Oncology, MianYang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Xiao-Bo
authors.identifier: http://orcid.org/0000-0001-6348-0636
authors.initials: XB
authors.lastname: Du
mesh_terms: D000428:Alcohol Drinking / Q000097:blood / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D012907:Smoking / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016877:Oxidants