title: A simple method for NMR t1noise suppression.
abstract: t1noise appears as random or semi-random spurious streaks along the indirect t1(F1) dimension of a 2D or nD NMR spectrum. It can significantly downgrade spectral quality, especially for spectra with strong diagonal signals such as NOESY, because useful and weak cross-peaks can be easily buried under t1noise. One of the significant contributing factors to t1noise is unwanted and semi-random F2 signal modulation during t1acquisition. As such, t1noise from different acquisitions is unlikely to correlate with each other strongly. In the case of NOESY, co-addition of multiple spectra significantly reduces t1noise compared with conventional acquisition with the same amount of total acquisition time and resolution.
authors.affiliation: Purdue Inter-Departmental NMR Facility (PINMRF), Purdue University, West Lafayette, IN 47907, USA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: hmo@purdue.edu.
authors.forename: Huaping
authors.initials: H
authors.lastname: Mo
authors.affiliation: Purdue Inter-Departmental NMR Facility (PINMRF), Purdue University, West Lafayette, IN 47907, USA; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: John S
authors.initials: JS
authors.lastname: Harwood
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Danzhou
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Carol Beth
authors.initials: CB
authors.lastname: Post
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003627:Data Interpretation, Statistical; D006801:Humans; D009113:Muramidase / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*
chemical_list: D009113:Muramidase; D009584:Nitrogen
keywords: 2D spectroscopy; Frequency fluctuation; NMR; NOESY; t(1) noise suppression