title: Brain and cognitive reserve: Translation via network control theory.
abstract: Traditional approaches to understanding the brain's resilience to neuropathology have identified neurophysiological variables, often described as brain or cognitive "reserve," associated with better outcomes. However, mechanisms of function and resilience in large-scale brain networks remain poorly understood. Dynamic network theory may provide a basis for substantive advances in understanding functional resilience in the human brain. In this perspective, we describe recent theoretical approaches from network control theory as a framework for investigating network level mechanisms underlying cognitive function and the dynamics of neuroplasticity in the human brain. We describe the theoretical opportunities offered by the application of network control theory at the level of the human connectome to understand cognitive resilience and inform translational intervention.
authors.affiliation: Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, United States.
authors.forename: John Dominic
authors.initials: JD
authors.lastname: Medaglia
authors.affiliation: Department of Mechanical Engineering, University of California-Riverside, Riverside, CA 92521, United States.
authors.forename: Fabio
authors.initials: F
authors.lastname: Pasqualetti
authors.affiliation: Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
authors.forename: Roy H
authors.initials: RH
authors.lastname: Hamilton
authors.affiliation: Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, United States.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Thompson-Schill
authors.affiliation: Department of Bioengineering, University of Pennsylvania, PA 19104, United States; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: dsb@seas.upenn.edu.
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Bassett
mesh_terms: D001921:Brain; D058245:Cognitive Reserve; D063132:Connectome; D006801:Humans; D009415:Nerve Net
keywords: Control theory; Graph theory; Network science; Neurology; Neuropsychology