title: Rab23's genetic structure, function and related diseases: a review.
abstract: Rab23 has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. Rab23 is also a negative regulator of the Sonic hedgehog (Shh) signaling pathway in an indirect way. The nonsense mutation and loss of protein of Rab23 has been associated with neural tube defect in mice and aberrant expression in various diseases in human such as neural system, breast, visceral, and cutaneous tumor. In addition, Rab23 may play joint roles in autophagosome formation during anti-infection process against Group A streptococcus. In this review, we give a brief review on the functions of Rab23, summarize the involvement of Rab23 in genetic research, membrane trafficking, and potential autophagy pathway, especially focus on tumor promotion, disease pathogenesis, and discuss the possible underlying mechanisms that are regulated by Rab23.
authors.affiliation: Department of Dermatology, Chinese PLA General Hospital, Beijing, China.|Department of Dermatology, the 251st Hospital of Chinese PLA, No.13.Jian'guo Road, Zhangjiakou City, Hebei Province, 075100, China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Zheng
authors.affiliation: Department of Physiology, Fourth Military Medical University, Xi'an, China chengxinderm@163.com chisumin@163.com.
authors.forename: Su-Min
authors.initials: SM
authors.lastname: Chi
authors.affiliation: Department of Dermatology, Chinese PLA General Hospital, Beijing, China chengxinderm@163.com chisumin@163.com.
authors.forename: Cheng-Xin
authors.initials: CX
authors.lastname: Li
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D021381:Protein Transport / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D020691:rab GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D053823:Hedgehog Proteins; D020691:rab GTP-Binding Proteins
keywords: G-proteins; Rab23; function; gene