title: Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury.
abstract: Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative stress frequently triggers antioxidant response by activating nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, which upregulates various cytoprotective genes. Thus, Nrf2 is considered a potential therapeutic target to halt liver injury. Several studies indicate that activation of Nrf2 signaling pathway ameliorates liver injury. The hepatoprotective potential of naturally occurring compounds has been investigated in various models of liver injuries. In this review, we comprehensively appraise various phytochemicals that have been assessed for their potential to halt acute and chronic liver injury by enhancing the activation of Nrf2 and have the potential for use in humans.
authors.affiliation: Digestive Health Center, Medical College of Georgia, Augusta, GA 30912, USA.
authors.forename: Ravirajsinh N
authors.identifier: 0000-0002-1712-454X
authors.initials: RN
authors.lastname: Jadeja
authors.affiliation: Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India.
authors.forename: Kapil K
authors.identifier: 0000-0002-0000-5085
authors.initials: KK
authors.lastname: Upadhyay
authors.affiliation: Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India.
authors.forename: Ranjitsinh V
authors.identifier: 0000-0002-9863-7418
authors.initials: RV
authors.lastname: Devkar
authors.affiliation: Digestive Health Center, Medical College of Georgia, Augusta, GA 30912, USA.
authors.forename: Sandeep
authors.identifier: 0000-0002-4955-4931
authors.initials: S
authors.lastname: Khurana
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006801:Humans; D019216:Metals, Heavy / Q000633:toxicity; D051267:NF-E2-Related Factor 2 / Q000819:agonists* / Q000378:metabolism; D018384:Oxidative Stress; D064209:Phytochemicals / Q000627:therapeutic use / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000975:Antioxidants; D019216:Metals, Heavy; D051267:NF-E2-Related Factor 2; D064209:Phytochemicals; D017382:Reactive Oxygen Species; D002251:Carbon Tetrachloride