title: Health-Related Quality of Life in Adolescent and Young Adult Patients With Cancer: A Longitudinal Study.
abstract: Purpose To examine changes in health-related quality of life (HRQoL) and its predictors during the first 2 years after initial cancer diagnosis in adolescent and young adult (AYA) patients with cancer. Patients and Methods A multicenter, longitudinal, prospective study was conducted among a diverse sample of AYA patients with cancer ages 15 to 39 years. One hundred seventy-six patients (75% response) completed a self-report measure of HRQoL (Short Form-36 [SF-36]) within the first 4 months after diagnosis and again 12 and 24 months later. Linear mixed models with random intercepts and slopes estimated changes in QoL. Results Recently diagnosed AYA patients with cancer had significantly worse physical component scale (PCS) scores (38.7 v 52.8; P < .001) and mental component scale (MCS) scores (42.9 v 48.9; P < .001) when compared with population norms. Significant improvements in PCS and MCS scores from baseline to 24-month follow-up were observed; however, these increases were largest during the first 12 months. At the 24-month follow-up, AYA patients still had significantly lower PCS scores (48.0 v 52.8; P < .001) and MCS scores (45.8 v 48.9; P = .002) when compared with population norms. Multivariable analyses revealed that improvements in PCS and MCS scores were primarily a function of being off-treatment and being involved in school or work. PCS but not MCS scores were worse for AYA patients diagnosed with cancers with poorer prognoses. Conclusion Although HRQoL improved over time, it was still compromised 24 months after primary diagnosis. Given relatively little observed improvement in HRQoL during the 12- to 24-month period after diagnosis, AYA patients may benefit from supportive care interventions administered during the second year after diagnosis.
authors.affiliation: Olga Husson, Radboud University Medical Center, Nijmegen, Netherlands; Brad J. Zebrack, University of Michigan School of Social Work, Ann Arbor, MI; Rebecca Block, MNR Analytics; Brandon Hayes-Lattin, Oregon Health and Sciences University, Portland, OR; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; and Steve Cole, HopeLab Foundation, Redwood City, CA.
authors.forename: Olga
authors.initials: O
authors.lastname: Husson
authors.affiliation: Olga Husson, Radboud University Medical Center, Nijmegen, Netherlands; Brad J. Zebrack, University of Michigan School of Social Work, Ann Arbor, MI; Rebecca Block, MNR Analytics; Brandon Hayes-Lattin, Oregon Health and Sciences University, Portland, OR; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; and Steve Cole, HopeLab Foundation, Redwood City, CA.
authors.forename: Brad J
authors.initials: BJ
authors.lastname: Zebrack
authors.affiliation: Olga Husson, Radboud University Medical Center, Nijmegen, Netherlands; Brad J. Zebrack, University of Michigan School of Social Work, Ann Arbor, MI; Rebecca Block, MNR Analytics; Brandon Hayes-Lattin, Oregon Health and Sciences University, Portland, OR; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; and Steve Cole, HopeLab Foundation, Redwood City, CA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Block
authors.affiliation: Olga Husson, Radboud University Medical Center, Nijmegen, Netherlands; Brad J. Zebrack, University of Michigan School of Social Work, Ann Arbor, MI; Rebecca Block, MNR Analytics; Brandon Hayes-Lattin, Oregon Health and Sciences University, Portland, OR; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; and Steve Cole, HopeLab Foundation, Redwood City, CA.
authors.forename: Leanne
authors.initials: L
authors.lastname: Embry
authors.affiliation: Olga Husson, Radboud University Medical Center, Nijmegen, Netherlands; Brad J. Zebrack, University of Michigan School of Social Work, Ann Arbor, MI; Rebecca Block, MNR Analytics; Brandon Hayes-Lattin, Oregon Health and Sciences University, Portland, OR; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; and Steve Cole, HopeLab Foundation, Redwood City, CA.
authors.forename: Christine
authors.initials: C
authors.lastname: Aguilar
authors.affiliation: Olga Husson, Radboud University Medical Center, Nijmegen, Netherlands; Brad J. Zebrack, University of Michigan School of Social Work, Ann Arbor, MI; Rebecca Block, MNR Analytics; Brandon Hayes-Lattin, Oregon Health and Sciences University, Portland, OR; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; and Steve Cole, HopeLab Foundation, Redwood City, CA.
authors.forename: Brandon
authors.initials: B
authors.lastname: Hayes-Lattin
authors.affiliation: Olga Husson, Radboud University Medical Center, Nijmegen, Netherlands; Brad J. Zebrack, University of Michigan School of Social Work, Ann Arbor, MI; Rebecca Block, MNR Analytics; Brandon Hayes-Lattin, Oregon Health and Sciences University, Portland, OR; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; and Steve Cole, HopeLab Foundation, Redwood City, CA.
authors.forename: Steve
authors.initials: S
authors.lastname: Cole
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009369:Neoplasms / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D011446:Prospective Studies; D011788:Quality of Life; D057566:Self Report; D055815:Young Adult