title: Genetic and Environmental Structure of DSM-IV Criteria for Antisocial Personality Disorder: A Twin Study.
abstract: Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level. Multivariate biometric models, including both independent and common pathways, were compared. A single phenotypic factor was found, and the best-fitting biometric model was a single-factor common pathway model, with common-factor heritability of 51% (95% CI 40-67%). In other words, both genetic and environmental correlations between the ASPD criteria could be accounted for by a single common latent variable. The findings support the validity of ASPD as a unidimensional diagnostic construct.
authors.affiliation: Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway. tom.rosenstrom@helsinki.fi.
authors.forename: Tom
authors.identifier: 0000-0001-8277-3776
authors.initials: T
authors.lastname: Rosenström
authors.affiliation: Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.|Department of Psychology, University of Oslo, Oslo, Norway.|PharmacoEpidemiology and Drug Safety Research Group, School of Pharmacy, University of Oslo, Oslo, Norway.
authors.forename: Eivind
authors.initials: E
authors.lastname: Ystrom
authors.affiliation: Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Fartein Ask
authors.initials: FA
authors.lastname: Torvik
authors.affiliation: Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.|Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Nikolai Olavi
authors.initials: NO
authors.lastname: Czajkowski
authors.affiliation: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Gillespie
authors.affiliation: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Aggen
authors.affiliation: Department of Psychology, University of Minnesota, Minneapolis, USA.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Krueger
authors.affiliation: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.|Deparment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.|Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
authors.affiliation: Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Ted
authors.initials: T
authors.lastname: Reichborn-Kjennerud
mesh_terms: D000328:Adult; D000987:Antisocial Personality Disorder / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004200:Diseases in Twins / Q000235:genetics*; D004777:Environment; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009664:Norway; D010641:Phenotype; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics; D055815:Young Adult
keywords: Common pathway; Diagnostics; Multivariate biometric model; Psychometrics; Unidimensionality