title: Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.
abstract: OBJECTIVE
  Enlarged adipocytes are a prime feature of adipose tissue dysfunction, and may be an appropriate target to decrease disease risk in obesity. We aimed to assess the change in adipocyte size in response to lifestyle and surgical weight loss interventions for overweight or obesity; and to explore whether certain participant and intervention characteristics influence this response.
  
  
  METHODS
  We systematically searched MEDLINE, EMBASE, CINAHL and Cochrane electronic databases to identify weight loss studies that quantified adipocyte size before and after the intervention. Using meta-regression analysis, we assessed the independent effects of weight loss, age, sex, adipocyte region, and intervention type (surgical vs. lifestyle) on adipocyte size reduction. We repeated the model as a sensitivity analysis including only the lifestyle interventions.
  
  
  RESULTS
  Thirty-five studies met our eligibility criteria. In our main model, every 1.0% weight loss was associated with a 0.64% reduction in adipocyte size (p=0.003); and adipocytes from the upper body decreased 5% more in size than those in the lower body (p=0.009). These relationships were no longer significant when focusing only on lifestyle interventions. Moreover, age, sex and intervention type did not independently affect adipocyte size reduction in either model.
  
  
  CONCLUSIONS
  Weight loss in obese individuals is consistently associated with a decrease in adipocyte size that is more pronounced in upper-body adipocytes. It remains to be clarified how biological differences and intervention characteristics influence this relationship, and whether it corresponds with reductions in other aspects of adipose tissue dysfunction and disease risk.
authors.affiliation: Department of Exercise Science, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5.
authors.forename: Jessica
authors.initials: J
authors.lastname: Murphy
authors.affiliation: Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5; École de Santé Publique - Département de Médecine Sociale et Preventive, Université de Montréal, 7101 du Parc Ave., Montreal, Quebec, Canada, H3N 1X9.
authors.forename: Grégory
authors.initials: G
authors.lastname: Moullec
authors.affiliation: Department of Exercise Science, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5. Electronic address: s.santosa@concordia.ca.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Santosa
mesh_terms: D017667:Adipocytes / Q000473:pathology* / Q000648:ultrastructure; D000273:Adipose Tissue / Q000503:physiopathology; D048429:Cell Size; D006801:Humans; D009765:Obesity / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D050177:Overweight / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D015431:Weight Loss
keywords: Adipocyte size; Adipose tissue dysfunction; Obesity; Weight loss