title: A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis.
abstract: OBJECTIVE
  The aim of this study was to compare dynamic thiol/disulfide homeostatic status in acute central serous chorioretinopathy (CSCR) patients by using a novel and automated assay determining dynamic thiol/disulfide homeostasis.
  
  
  METHODS
  Fifty-one patients with acute CSCR (study group) and 65 healthy individuals (control group) were enrolled in this study. Diagnosis of acute CSCR was made clinically and using spectral-domain RTVue OCT (optical coherence tomography) (Optovue, Fremont, CA). Fluorescein angiography confirmed the diagnosis of acute CSCR in all subjects. Total thiol, native thiol, disulfide amount, and native thiol/disulfide ratio (TDR) were calculated in the blood samples.
  
  
  RESULTS
  Mean total thiol, native thiol, and native TDR values were lower in patients with acute CSCR (364.2 ± 14.1, 326.4 ± 13.2, 17.14 ± 1.9, respectively) than in healthy eyes (441.2 ± 16.3, 398.5 ± 16.4, 22.70 ± 2.15, respectively; mean total thiol, p = 0.017; native thiol, p = 0.011; native TDR, p = 0.031).
  
  
  CONCLUSIONS
  Total thiol, native thiol, and native TDR were significantly lower statistically in patients with acute CSCR when compared with healthy controls.
authors.affiliation: Department of Ophthalmology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey. altinkaynak167@yahoo.com.
authors.forename: Hasan
authors.initials: H
authors.lastname: Altinkaynak
authors.affiliation: Department of Ophthalmology, World Eye Hospital, Ankara, Turkey.
authors.forename: Piraye Zeynep
authors.initials: PZ
authors.lastname: Kurkcuoglu
authors.affiliation: Department of Ophthalmology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Caglayan
authors.affiliation: Department of Ophthalmology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Mücella Arıkan
authors.initials: MA
authors.lastname: Yorgun
authors.affiliation: Department of Ophthalmology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Nilay
authors.initials: N
authors.lastname: Yuksel
authors.affiliation: Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Kosekahya
authors.affiliation: Department of Biochemistry, Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
authors.affiliation: Department of Ophthalmology, Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Toklu
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006706:Homeostasis; D006801:Humans; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013438:Sulfhydryl Compounds / Q000097:blood*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Central serous chorioretinopathy; Native thiol; Thiol/disulfide ratio; Total thiol