title: Recovery from Proactive Semantic Interference in Mild Cognitive Impairment and Normal Aging: Relationship to Atrophy in Brain Regions Vulnerable to Alzheimer's Disease.
abstract: There is growing evidence that proactive semantic interference (PSI) and failure to recover from PSI may represent early features of Alzheimer's disease (AD).
  
  
  
  This study investigated the association between PSI, recovery from PSI, and reduced MRI volumes in AD signature regions among cognitively impaired and unimpaired older adults.
  
  
  
  Performance on the LASSI-L (a novel test of PSI and recovery from PSI) and regional brain volumetric measures were compared between 38 cognitively normal (CN) elders and 29 older participants with amnestic mild cognitive impairment (MCI). The relationship between MRI measures and performance on the LASSI-L as well as traditional memory and non-memory cognitive measures was also evaluated in both diagnostic groups.
  
  
  
  Relative to traditional neuropsychological measures, MCI patients' failure to recover from PSI was associated with reduced volumes in the hippocampus (rs = 0.48), precuneus (rs = 0.50); rostral middle frontal lobules (rs = 0.54); inferior temporal lobules (rs = 0.49), superior parietal lobules (rs = 0.47), temporal pole (rs = 0.44), and increased dilatation of the inferior lateral ventricle (rs = -0.49). For CN elders, only increased inferior lateral ventricular size was associated with vulnerability to PSI (rs = -0.49), the failure to recover from PSI (rs = -0.57), and delayed recall on the Hopkins Verbal Learning Test-Revised (rs = -0.48).
  
  
  
  LASSI-L indices eliciting failure to recover from PSI were more highly associated with more MRI regional biomarkers of AD than other traditional cognitive measures. These results as well as recent amyloid imaging studies with otherwise cognitively normal subjects, suggest that recovery from PSI may be a sensitive marker of preclinical AD and deserves further investigation.
authors.affiliation: Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA.|Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center, Miami Beach, FL, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Loewenstein
authors.affiliation: Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Rosie E
authors.initials: RE
authors.lastname: Curiel
authors.affiliation: Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Clinton
authors.initials: C
authors.lastname: Wright
authors.affiliation: Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Radiology, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Noam
authors.initials: N
authors.lastname: Alperin
authors.affiliation: Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Elzabeth
authors.initials: E
authors.lastname: Crocco
authors.affiliation: Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Czaja
authors.affiliation: Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Arlene
authors.initials: A
authors.lastname: Raffo
authors.affiliation: Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Ailyn
authors.initials: A
authors.lastname: Penate
authors.affiliation: Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Melo
authors.affiliation: Department of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Capp
authors.affiliation: Department of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Gamez
authors.affiliation: Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center, Miami Beach, FL, USA.|Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Duara
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology / Q000523:psychology*; D000544:Alzheimer Disease; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000523:psychology*; D005260:Female; D006801:Humans; D007858:Learning; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall; D009483:Neuropsychological Tests; D009929:Organ Size; D012660:Semantics
keywords: Alzheimer’s disease; LASSI-L; MRI; memory; mild cognitive impairment; proactive interference; semantic interference