title: A Case-control Study on Risk Factors for Severe Hand, Foot and Mouth Disease.
abstract: The objective of this study was to identify potential risk factors for severe hand, foot and mouth disease (HFMD). In this case-control study, 459 severe HFMD patients and 246 mild HFMD patients from Guangdong province and Henan province, China were included. Data comprising demographic characteristics, clinical symptoms and signs, laboratory findings and other factors were collected. Univariate analysis revealed 30 factors associated with severe cases. Further multivariate analysis indicated four independent risk factors: fatigue (p < 0.01, odd ratio [OR] = 204.7), the use of glucocorticoids (p = 0.03, OR = 10.44), the use of dehydrant drugs (p < 0.01, OR = 73.7) and maculopapular rash (p < 0.01, OR = 84.4); and one independent protective factor: herpes or ulcers in mouth (p = 0.01, OR = 0.02). However, more systematic research and validation are needed to understand the underlying risk factors for severe HFMD.
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Dingmei
authors.initials: D
authors.lastname: Zhang
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Ruolin
authors.initials: R
authors.lastname: Li
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Wangjian
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Zhengzhou Center for Disease Control and Prevention, Zhengzhou, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, Yuebei People's Hospital, Shaoguan, China.
authors.forename: Zhanzhong
authors.initials: Z
authors.lastname: Ma
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiashi
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Du
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Li
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Pi
authors.initials: P
authors.lastname: Guo
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhuochen
authors.initials: Z
authors.lastname: Lin
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jiahai
authors.initials: J
authors.lastname: Lu
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yuantao
authors.initials: Y
authors.lastname: Hao
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000503:physiopathology; D006562:Herpes Zoster / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D019226:Oral Ulcer / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors