title: Type I Interferon in Malaria: A Balancing Act.
abstract: Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical protection to malaria. New studies recently highlighted a central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of proinflammatory responses, expansion of type 1 regulatory (Tr1) cells, and restriction of humoral immunity during malaria blood stage infection. Plasmacytoid dendritic cells (pDCs) were identified as the major source of IFN-Is. Here, we integrate the findings and provide a model for the mechanisms involved.
authors.affiliation: Immunology and Infection Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Jason Paul
authors.initials: JP
authors.lastname: Mooney
authors.affiliation: Immunology and Infection Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Samuel Crocodile
authors.initials: SC
authors.lastname: Wassmer
authors.affiliation: Immunology and Infection Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Electronic address: Julius.Hafalla@lshtm.ac.uk.
authors.forename: Julius Clemence
authors.initials: JC
authors.lastname: Hafalla
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology*; D007370:Interferon Type I / Q000378:metabolism*; D008288:Malaria / Q000276:immunology*; D008954:Models, Biological; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology
chemical_list: D007370:Interferon Type I
keywords: IL-10; Interferon; Plasmodium; Tr1; Type I interferon; immunoregulation