title: Structure-activity relationship of flavanone. Anti-degranulation activity of 7-O-substituted hesperetin.
abstract: A series of 7-O-substituted hesperetins was evaluated for degranulation-inhibiting activity in rat basophil leukaemia cells. 7-O-Methyl and 7-O-ethyl hesperetin exhibited potent anti-degranulation activity compared with the original hesperetin.
authors.affiliation: a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Hiroshima , Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Noshita
authors.affiliation: a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Hiroshima , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tai
authors.affiliation: b Faculty of Life and Environmental Sciences, Department of Environmental Sciences , Prefectural University of Hiroshima , Hiroshima , Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: c Program in Biological System Sciences, Graduate School of Comprehensive Scientific Research , Prefectural University of Hiroshima , Hiroshima , Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Miura
authors.affiliation: c Program in Biological System Sciences, Graduate School of Comprehensive Scientific Research , Prefectural University of Hiroshima , Hiroshima , Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: d Graduate School of Engineering , Osaka Electro-Communication University , Neyagawa , Japan.
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Hamada
mesh_terms: D000818:Animals; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D044950:Flavanones / Q000737:chemistry* / Q000494:pharmacology*; D006569:Hesperidin / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D044950:Flavanones; D006569:Hesperidin; C013015:hesperetin
keywords: 7-O-alkyl hesperetin; 7-O-ethyl hesperetin; 7-O-methyl hesperetin; Hesperetin; degranulation-inhibiting activity; structure–activity relationship