title: Cribriform adenocarcinoma of the soft palate with multiple lymph node metastasis and long-term follow-up.
abstract: BACKGROUND
  Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a recently described entity, with most cases previously published as polymorphous low-grade adenocarcinoma (PLGA). Typical cases share some main characteristics, such as oral sites (mainly tongue), regional lymph node metastasis, and morphology resembling solid and follicular variants of papillary thyroid carcinoma.
  
  
  OBJECTIVE
  To present a CATMSG and emphasize the importance of reclassifying PLGAs with unusual behavior.
  
  
  METHODS
  A 78-year-old male presented with an ulcerated mass in the soft palate treated as PLGA. The patient developed 5 regional metastases over 11 years of follow-up, all diagnosed as PLGA. He died due to the disease, and because of the very aggressive behavior of PLGA, all histopathologic slides were revised and the tumor was reclassified as CATMSG.
  
  
  CONCLUSIONS
  This report emphasizes the importance of reevaluating aggressive PLGA and contributes to a better understanding of CATMSG.
authors.affiliation: Pathology Department, Faculty of Medical Sciences, State University of Campinas, Brazil. Electronic address: fevimariano@gmail.com.
authors.forename: Fernanda Viviane
authors.initials: FV
authors.lastname: Mariano
authors.affiliation: Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas, Brazil.
authors.forename: Renata Freitas
authors.initials: RF
authors.lastname: Varanda
authors.affiliation: Institute of Pathological Anatomy, Piracicaba-SP, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Schultz
authors.affiliation: Oncology Center, Fornecedores de Cana Hospital, Piracicaba-SP, Brazil.
authors.forename: Marcelo Brum
authors.initials: MB
authors.lastname: Correa
authors.affiliation: Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas, Brazil.
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
authors.affiliation: Pathology Department, Faculty of Medical Sciences, State University of Campinas, Brazil.
authors.forename: Albina
authors.initials: A
authors.lastname: Altemani
authors.affiliation: Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas, Brazil.
authors.forename: Márcio Ajudarte
authors.initials: MA
authors.lastname: Lopes
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D010157:Palatal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D010160:Palate, Soft; D011862:Radiography, Panoramic; D012468:Salivary Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014062:Tongue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*