title: Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model.
abstract: In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77005, USA.|Division of Congenital Heart Surgery, Texas Children's Hospital, Houston, TX 77030, USA.
authors.forename: Seokwon
authors.initials: S
authors.lastname: Pok
authors.affiliation: Department of Basic Radiology Research, Texas Children's Hospital, Houston, TX 77030, USA.
authors.forename: Igor V
authors.initials: IV
authors.lastname: Stupin
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77005, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Tsao
authors.affiliation: Department of Molecular Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Robia G
authors.initials: RG
authors.lastname: Pautler
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77005, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Division of Congenital Heart Surgery, Texas Children's Hospital, Houston, TX 77030, USA.
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Nieto
authors.affiliation: Department of Bioengineering, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Ze-Wei
authors.initials: ZW
authors.lastname: Tao
authors.affiliation: Division of Congenital Heart Surgery, Texas Children's Hospital, Houston, TX 77030, USA.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Fraser
authors.affiliation: Department of Basic Radiology Research, Texas Children's Hospital, Houston, TX 77030, USA.
authors.forename: Ananth V
authors.initials: AV
authors.lastname: Annapragada
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77005, USA.|Division of Congenital Heart Surgery, Texas Children's Hospital, Houston, TX 77030, USA.|Department of Bioengineering, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Jacot
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D009206:Myocardium; D010496:Pericardium; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020100:Hydrogels; D008567:Membranes, Artificial; D011091:Polyesters; C016240:polycaprolactone; D048271:Chitosan
keywords: chitosan; congenital heart defects; heart patch; polycaprolactone; right ventricular outflow tract