title: Repurposing of Potent Drug Candidates for Multiparasite Targeting.
abstract: Parasite-directed drug discovery efforts require sustained and substantial scientific resources. Many eukaryotic parasites share similarities in metabolic pathways and housekeeping genes, as evident from their underlying protein sequences. Their subsequent structural congruence within enzyme active sites can thus be leveraged for multiparasite targeting using similar or identical drug probes. This bodes well for delivering new anti-infectives.
authors.affiliation: Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Road, New Delhi 110067, India.
authors.forename: Vitul
authors.initials: V
authors.lastname: Jain
authors.affiliation: Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Road, New Delhi 110067, India. Electronic address: amit.icgeb@gmail.com.
authors.forename: Amit
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D055808:Drug Discovery; D058492:Drug Repositioning; D056890:Eukaryota; D006801:Humans; D010271:Parasites; D010272:Parasitic Diseases / Q000188:drug therapy*
chemical_list: D000977:Antiparasitic Agents