title: Reduced serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes.
abstract: BACKGROUND
  The association between serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations and vascular complications in T2DM remains unclear.
  
  
  METHODS
  A total of 149 patients with T2DM were included. The serum concentrations of MFG-E8, glycosylated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured.
  
  
  RESULTS
  There was no significant difference in serum MFG-E8 concentrations between the T2DM group and the T2DM with subclinical atherosclerosis (AS) group (615.49±143.54 vs. 596.22±79.46ng/ml, P=0.365), while the serum concentrations of MFG-E8 in the T2DM with microvascular complications group (446.70±61.53ng/ml) and the T2DM with subclinical AS and microvascular complications group (200.87±38.86ng/ml) were significantly lower than those in the T2DM group (P=0.000 for both). In addition, hs-CRP and HbAlc concentrations were independently associated with serum MFG-E8 concentrations (P=0.024 and P=0.01, respectively), and low serum MFG-E8 concentrations were significantly associated with an increased risk of microvascular complications in T2DM patients.
  
  
  CONCLUSIONS
  Serum concentrations of MFG-E8 were negatively associated with the risk of microvascular complications in patients with T2DM. Thus, it might be a potential candidate biomarker for diabetic microvascular complications.
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Ningxia Medical University, Yinchuan, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Key Lab of Endocrine and Metabolic Diseases of Gansu Province, Lanzhou, China.
authors.forename: Juxiang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Key Lab of Endocrine and Metabolic Diseases of Gansu Province, Lanzhou, China.
authors.forename: Guanghao
authors.initials: G
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Clinical and Translational Medicine, Gansu Provincial Hospital, Lanzhou, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Ultrasonic Diagnostic Center, Gansu Provincial Hospital, Lanzhou, China.
authors.forename: Zubang
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Key Lab of Endocrine and Metabolic Diseases of Gansu Province, Lanzhou, China.
authors.forename: Yaya
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Key Lab of Endocrine and Metabolic Diseases of Gansu Province, Lanzhou, China.
authors.forename: Suhong
authors.initials: S
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Key Lab of Endocrine and Metabolic Diseases of Gansu Province, Lanzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Key Lab of Endocrine and Metabolic Diseases of Gansu Province, Lanzhou, China. Electronic address: quanxt@sina.com.
authors.forename: Jinxing
authors.initials: J
authors.lastname: Quan
mesh_terms: D000954:Antigens, Surface / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D048909:Diabetes Complications / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D055806:Microvessels / Q000473:pathology*; D008894:Milk Proteins / Q000097:blood*; D012307:Risk Factors
chemical_list: D000954:Antigens, Surface; D015415:Biomarkers; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D008894:Milk Proteins; C098942:MFGE8 protein, human; C517652:hemoglobin A1c protein, human
keywords: Atherosclerosis; Milk fat globule epidermal growth factor 8; Type 2 diabetes mellitus; Vascular complications