title: [Acute renal failure in a 75-year-old woman with a high-output ileostoma].
abstract: We report on a 75-year old woman who presented with acute oliguric renal failure. The kidney biopsy revealed calcium oxalate depositions in the tubular lumen, caused by an overload of intravenous ascorbic acid (cumulative dose of 240 g). Due to a lack of specific therapeutic interventions, the patient remained dialysis-dependent. Iatrogenic causes of kidney failure play an important role in the pathogenesis of kidney diseases and should always be considered in patients with acute renal failure. Detailed evaluation of the patient history is often suggestive, while renal biopsy can establish the diagnosis.
authors.affiliation: III. Medizinische Klinik, Abteilung Nephrologie, Zentrum für Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland. s.teege@uke.de.
authors.forename: S
authors.initials: S
authors.lastname: Teege
authors.affiliation: Institut für Pathologie, Sektion Nephropathologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Wiech
authors.affiliation: III. Medizinische Klinik, Abteilung Nephrologie, Zentrum für Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
authors.forename: O M
authors.initials: OM
authors.lastname: Steinmetz
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D000368:Aged; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D002129:Calcium Oxalate / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D009846:Oliguria / Q000209:etiology; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014815:Vitamins; D002129:Calcium Oxalate; D001205:Ascorbic Acid
keywords: Ascorbic acid; Calcium oxalate; Kidney biopsy; Oliguria; Renal insufficiency, iatrogenic disease