title: ZiBuPiYin recipe improves cognitive decline by regulating gut microbiota in Zucker diabetic fatty rats.
abstract: Numerous researches supported that microbiota can influence behavior and modulate cognitive function through "microbiota-gut-brain" axis. Our previous study has demonstrated that ZiBuPiYin recipe (ZBPYR) possesses excellent pharmacological effects against diabetes-associated cognitive decline. To elucidate the role of ZBPYR in regulating the balance of gut microbiota to improve psychological-stress-induced diabetes-associated cognitive decline (PSDACD), we compared blood glucose, behavioral and cognitive functions and diversity of the bacterial community among experimental groups. The Zucker diabetic fatty (ZDF) rats with PSDACD exhibited behavioral and cognitive anomalies showing as increased anxiety- and depression-like behaviors and decreased learning and memory abilities. High-throughput sequencing of the bacterial 16S rRNA gene revealed that Roseburia and Coprococcus were decreased in ZDF rats with PSDACD compared with control group. Notably, these changes were reversed by ZBPYR treatment. Our findings indicate that ZBPYR might prevent PSDACD by maintaining the compositions of gut microbiota, which could be developed as a new therapy for T2D with PSDACD.
authors.affiliation: School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Gu
authors.affiliation: Basic Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhou
authors.affiliation: School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Wang
authors.affiliation: The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xiang
authors.affiliation: Basic Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Xu
authors.affiliation: Institute of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Liang
authors.affiliation: Institute of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Sui
authors.affiliation: Basic Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.|The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian, Liaoning, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Lu
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D001786:Blood Glucose / Q000032:analysis; D003071:Cognition / Q000187:drug effects; D060825:Cognitive Dysfunction / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008516:Medicine, Chinese Traditional; D009154:Mutation; D012336:RNA, Ribosomal, 16S / Q000302:isolation & purification*; D051381:Rats; D011924:Rats, Zucker; D054411:Receptors, Leptin / Q000235:genetics; D017423:Sequence Analysis, RNA; D065852:Spatial Memory / Q000187:drug effects; D013315:Stress, Psychological / Q000150:complications
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D012336:RNA, Ribosomal, 16S; D054411:Receptors, Leptin; C515447:leptin receptor, mouse
keywords: Pathology Section; ZiBuPiYin recipe; cognitive decline; diabetes; gut microbiota; psychological-stress