title: [Effects of polyethylene oxide on blood perfusion in the hind limbs of rats with chronic hindlimb ischemia].
abstract: OBJECTIVE
  To evaluate the effects of polyethylene oxide (PEO) on blood perfusion in hind limb skeletal muscles in a rat model of chronic hind limb ischemia.
  
  
  METHODS
  Twelve rat models of chronic hind limb ischemia established by unilateral femoral artery ligation were randomized into PEO and control groups (n=6) and treated with intravenous infusion of PEO and saline through the internal jugular vein every other day for 2 weeks. Contrast-enhanced ultrasonography was performed after the treatments to evaluate the blood flow in the skeletal muscles at different time points and blood flow reserve in the ischemic hind limbs on day 28.
  
  
  RESULTS
  Starting from 7 days after femoral artery ligation, blood flow in the ischemic hind limb skeletal muscles was significantly higher in PEO group than in the control group (P<0.05). On day 28, blood flow reserve in the ischemic hind limb was significantly higher (P=0.012), and blood volume was significantly increased in PEO group as compared that in the control group (P=0.024).
  
  
  CONCLUSIONS
  PEO can increase blood flow, blood flow reserve and vascular volume in the hind limb skeletal muscles in rats with chronic hind limb ischemia, suggesting that PEO can promote angiogenesis and arterial formation by increasing blood flow shear stress to improve blood supply of ischemic hind limbs.
authors.affiliation: Department of Cardiology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.E-mail: 61815443@qq.com.
authors.forename: De-Zhong
authors.initials: DZ
authors.lastname: Zheng
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Dao-Gang
authors.initials: DG
authors.lastname: Zha
mesh_terms: D000818:Animals; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D002908:Chronic Disease; D004195:Disease Models, Animal; D005263:Femoral Artery; D006614:Hindlimb / Q000098:blood supply / Q000187:drug effects*; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008026:Ligation; D018482:Muscle, Skeletal / Q000098:blood supply / Q000187:drug effects*; D018919:Neovascularization, Physiologic; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology
chemical_list: D011092:Polyethylene Glycols