title: Mechanistic insight into nuclear receptor-mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE).
abstract: Dietary procyanidins have emerged as important bioactive components that regulate various metabolic pathways to maintain homeostasis. Grape seed procyanidin extract (GSPE), in particular, has demonstrated regulatory effects on bile acid and lipid metabolism in vivo. While numerous studies in rodent models have shown the potent hypolipidemic action of grape seed extracts, human studies have shown inconsistent results. This review will focus on the molecular mechanisms underlying the hypolipidemic actions of GSPE identified to date, specifically highlighting the effects exerted via nuclear receptors. Such evidence may provide avenues for future research in human subjects with GSPE as a therapeutic treatment for the prevention and amelioration of the metabolic syndrome and cardiovascular disease.
authors.affiliation: Department of Agriculture, Nutrition and Veterinary Sciences, University of Nevada Reno, Reno, Nevada, USA.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Downing
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Nevada Reno, Reno, Nevada, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Edgar
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Nevada Reno, Reno, Nevada, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Ellison
authors.affiliation: Department of Agriculture, Nutrition and Veterinary Sciences, University of Nevada Reno, Reno, Nevada, USA.
authors.forename: Marie-Louise
authors.identifier: http://orcid.org/0000-0002-8306-7563
authors.initials: ML
authors.lastname: Ricketts
mesh_terms: D000818:Animals; D044946:Biflavonoids / Q000737:chemistry / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002392:Catechin / Q000737:chemistry / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D056604:Grape Seed Extract / Q000737:chemistry; D050356:Lipid Metabolism / Q000187:drug effects*; D023421:Models, Animal; D044945:Proanthocyanidins / Q000737:chemistry / Q000494:pharmacology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism; D027843:Vitis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D044946:Biflavonoids; D001647:Bile Acids and Salts; D056604:Grape Seed Extract; D044945:Proanthocyanidins; D018160:Receptors, Cytoplasmic and Nuclear; D014280:Triglycerides; C017674:procyanidin; D002392:Catechin; D002784:Cholesterol
keywords: bile acids; cholesterol; nuclear receptors; procyanidins; triglycerides