title: Biocompatibility of Modified Osteoinductive Calcium-Phosphate Coatings of Metal Implants.
abstract: The cellular and molecular aspects of immunological compatibility of modified osteoinductive calcium-phosphate coatings formed on technically pure titanium VT1-0 by the plasma electrolytic oxidation technology are studied. The technique of coating modified the process of human peripheral blood leukocyte activation in vitro. The most pronounced functional changes were observed in neutrophil population during whole blood contact with titanium sample without coating and with coating formed by plasma electrolytic oxidation on titanium alloy. Sealing of the oxidation layer pores by ultradispersed polytetrafluoroethylene leads to reduction of cell activation. Composite coatings with ultradispersed polytetrafluoroethylene applied by the electrophoretic method are characterized by the best biocompatibility. The data demonstrate the possibility of modifying biomaterial surfaces for inflammatory response control.
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia. niiem_vl@mail.ru.
authors.forename: T S
authors.initials: TS
authors.lastname: Zaporozhets
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Puz'
authors.affiliation: Institute of Chemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: S L
authors.initials: SL
authors.lastname: Sinebryukhov
authors.affiliation: Institute of Chemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Gnedenkov
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: T P
authors.initials: TP
authors.lastname: Smolina
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D015870:Gene Expression; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D010084:Oxidation-Reduction; D058626:Plasma Gases / Q000494:pharmacology; D011138:Polytetrafluoroethylene / Q000737:chemistry / Q000494:pharmacology*; D061251:Primary Cell Culture; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000497:Alloys; D015703:Antigens, CD; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D058626:Plasma Gases; D011138:Polytetrafluoroethylene; D014025:Titanium
keywords: activation antigens; bioactivity/bioinertness; hydroxyapatite; implants