title: Radiochemical studies, pre-clinical investigation and preliminary clinical evaluation of170Tm-EDTMP prepared using in-house freeze-dried EDTMP kit.
abstract: The objective of the present work is to formulate170Tm-EDTMP using an in-house freeze-dried EDTMP kit and evaluate its potential as a bone pain palliation agent. Patient dose of170Tm-EDTMP was prepared with high radiochemical purity using the lyophilized kit at room temperature within 15min. Pre-clinical evaluation in normal Wistar rats revealed selective skeletal accumulation with extended retention. Preliminary clinical investigation in 8 patients with disseminated skeletal metastases exhibited selective uptake in the bone and retention therein for a long duration.
authors.affiliation: Radiopharmaceuticals Chemistry Section, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India. Electronic address: tdas@barc.gov.in.
authors.forename: Tapas
authors.initials: T
authors.lastname: Das
authors.affiliation: Department of Nuclear Medicine & PET, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu 641014, India.
authors.forename: Ajit
authors.initials: A
authors.lastname: Shinto
authors.affiliation: Department of Nuclear Medicine & PET, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu 641014, India.
authors.forename: Koramadai K
authors.initials: KK
authors.lastname: Kamaleshwaran
authors.affiliation: Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Haladhar D
authors.initials: HD
authors.lastname: Sarma
authors.affiliation: Isotope Production and Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Sahiralam Khan
authors.initials: SK
authors.lastname: Mohammed
authors.affiliation: Radiation Medicine Cnetre, Bhabha Atomic Research Centre, Mumbai 400012, India.
authors.forename: Arpit
authors.initials: A
authors.lastname: Mitra
authors.affiliation: Radiation Medicine Cnetre, Bhabha Atomic Research Centre, Mumbai 400012, India.
authors.forename: Sangita
authors.initials: S
authors.lastname: Lad
authors.affiliation: Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India; Radiation Medicine Cnetre, Bhabha Atomic Research Centre, Mumbai 400012, India.
authors.forename: M G R
authors.initials: MGR
authors.lastname: Rajan
authors.affiliation: Radiopharmaceuticals Chemistry Section, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000368:Aged; D000818:Animals; D001859:Bone Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008875:Middle Aged; D023421:Models, Animal; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D063065:Organophosphonates / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D010148:Intractable Pain / Q000188:drug therapy* / Q000378:metabolism; D010166:Palliative Care / Q000379:methods*; D017208:Rats, Wistar; D013932:Thulium / Q000008:administration & dosage / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: C543419:170Tm-ethylenediamine-tetramethylenephosphonic acid; D009942:Organometallic Compounds; D063065:Organophosphonates; D013932:Thulium
keywords: (170)Tm; (170)Tm-EDTMP; Freeze-dried EDTMP kit; Metastatic bone pain palliation; Pharmacokinetics