title: Antitumoral activity of sesquiterpene lactone diacethylpiptocarphol in mice.
abstract: BACKGROUND
  Sesquiterpene lactones are organic compounds derived from plants that exhibit anti-inflammatory and antitumor activities being one of the locking mechanisms of action of NF-kB pathway and synthesis of cytokines such as IL-1 and TNF- α.
  
  
  OBJECTIVE
  The overall objective of the present study was to evaluate the antitumor activity of the sesquiterpene lactone diacethylpiptocarphol (DPC) from Vernonia scorpioides (Lam.) Pers. in animal models Ehrlich tumors that has shown antitumor activity.
  
  
  METHODS
  The antitumor effects of Intraperitonial administration of DPC (5mg/kg/day) were evaluated in Balb/c mice on Ehrlich tumors, and further the body weight, the ascitic cells volume measurement, solid tumor measured and TNF-α level was determinate.
  
  
  RESULTS
  Balb/c mice bearing Ehrlich tumors were treated daily with 5mg/kg/day of the DPC for one week and showed no tumor in the peritoneum after treatment, besides presenting a reduction of TNF-α cytokine. Also the solid tumor reduced size after one week of treatment with DPC.
  
  
  CONCLUSIONS
  Sesquiterpene lactone DPC, isolated from Vernonia scorpioides showed antitumor activity because it decreased the size of the solid tumor and abolished the ascitic tumor development, and also did not affect the mice body weight, however the treatment reduced the TNF-α level in mice.
authors.affiliation: Universidade do Vale do Itajaí, Brazil.
authors.forename: Fronza
authors.initials: F
authors.lastname: Alexandre Schefer
authors.affiliation: Universidade do Vale do Itajaí, Brazil.
authors.forename: Sabel
authors.initials: S
authors.lastname: Ricardo
authors.affiliation: Faculdade Avantis de Ensino Superior, Brazil.
authors.forename: Carrenho Luise
authors.initials: CL
authors.lastname: Zozula Blind
authors.affiliation: Universidade do Vale do Itajaí, Brazil.
authors.forename: Pollo
authors.initials: P
authors.lastname: Luis
authors.affiliation: Universidade Federal de Santa Catarina, Brazil.
authors.forename: Bratti Letícia
authors.initials: BL
authors.lastname: de Oliveira Souza
authors.affiliation: Universidade Federal de Santa Catarina, Brazil.
authors.forename: Monteiro Fabíola
authors.initials: MF
authors.lastname: Branco Filippin
authors.affiliation: Universidade Federal de Santa Catarina, Brazil.
authors.forename: Biavatti Maique
authors.initials: BM
authors.lastname: Weber
authors.affiliation: Universidade do Vale do Itajaí, Brazil; Faculdade Avantis de Ensino Superior, Brazil. Electronic address: orofinokreuger@gmail.com.
authors.forename: Kreuger Maria
authors.initials: KM
authors.lastname: Regina Orofino
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D035741:Vernonia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; C000620987:diacethylpiptocarphol
keywords: Diacethylpiptocarphol; Erlich; Sesquiterpene lactones; Tumor