title: Bordetella pertussis infection in children with severe pneumonia, Philippines, 2012-2015.
abstract: A case-comparison study was conducted based on an observational study of severe pneumonia among hospitalized children in the Philippines. The children, from 8days to 13years old and hospitalized with clinical diagnosis of severe or very severe pneumonia from August 2012 to February 2015, were recruited. Nasopharyngeal swabs were collected from 1152 cases and B. pertussis were detected from 34 cases by PCR. Pertussis-positive cases were more likely to have no fever, more than one week of coughing and breathing difficulty, decreased breathing sounds, and central cyanosis than pertussis- negative cases. The percentage of underweight was significantly higher in pertussis-positive cases than pertussis-negative cases. Pertussis-positive cases showed remarkably higher fatality rate than pertussis-negative cases. All of the fatal cases among pertussis-positive cases were less than 6months old. More attention should be given to protect young infants from pertussis.
authors.affiliation: Research Institute for Tropical Medicine 17, Muntinlupa City, Metro Manila, Philippines.
authors.forename: Alexander
authors.initials: A
authors.lastname: Sadiasa
authors.affiliation: Tohoku University Graduate School of Medicine, Sendai, Japan; Tohoku-RITM Collaborating Research Center on Emerging and Reemerging Infectious Diseases, Muntinlupa City, Metro Manila, Philippines. Electronic address: saitom@med.tohoku.ac.jp.
authors.forename: Mariko
authors.initials: M
authors.lastname: Saito-Obata
authors.affiliation: Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Clyde
authors.initials: C
authors.lastname: Dapat
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001886:Bordetella pertussis / Q000472:pathogenicity* / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000382:microbiology / Q000473:pathology*; D010679:Philippines; D018410:Pneumonia, Bacterial / Q000150:complications / Q000382:microbiology / Q000401:mortality / Q000473:pathology*; D012720:Severity of Illness Index; D016019:Survival Analysis; D014917:Whooping Cough / Q000150:complications / Q000382:microbiology / Q000401:mortality / Q000473:pathology*
keywords: Bordetella pertussis; Philippines