title: Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant.
abstract: Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients' blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure:r= 0.416;P= 0.001; pulse pressure:r= 0.412;P= 0.003). The endocan levels were inversely correlated with the estimated glomerular filtration rate (r= -0.388;P= 0.003). An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity. In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function. The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.
authors.affiliation: Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Livia Victorino
authors.initials: LV
authors.lastname: de Souza
authors.affiliation: Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Oliveira
authors.affiliation: Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Aline Oliveira
authors.initials: AO
authors.lastname: Laurindo
authors.affiliation: Pediatrics Department, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: DelmaRegına Gomes
authors.initials: DG
authors.lastname: Huarachı
authors.affiliation: Pediatrics Department, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Paulo Cesar Koch
authors.initials: PC
authors.lastname: Nogueira
authors.affiliation: Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Luciana de Santis
authors.initials: LS
authors.lastname: Feltran
authors.affiliation: Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: José Osmar
authors.initials: JO
authors.lastname: Medina-Pestana
authors.affiliation: Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Maria do Carmo
authors.identifier: 0000-0003-0604-7689
authors.initials: MD
authors.lastname: Franco