title: Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer.
abstract: We performed diagnostic classification of plasma specimens from patients with non-metastatic and metastatic prostate cancer based on pairs of miRNA that have no individual diagnostic significance. Of 230 miRNA detected in plasma specimens, 3 pairs were diagnostically significant. The miRNA pair hsa-miR-19b-3p and hsa-miR-297 demonstrated highest sensitivity and specificity. Among common target genes of these miRNA, CFL2 gene associated with cell mobility was detected.
authors.affiliation: BioClinicum Research and Development Centre, Moscow, Russia.|P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Osip'yants
authors.affiliation: BioClinicum Research and Development Centre, Moscow, Russia.|P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Knyazev
authors.affiliation: BioClinicum Research and Development Centre, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Galatenko
authors.affiliation: P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: K M
authors.initials: KM
authors.lastname: Nyushko
authors.affiliation: BioClinicum Research and Development Centre, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Galatenko
authors.affiliation: P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia. mshkurnikov@gmail.com.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Shkurnikov
authors.affiliation: P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: B Ya
authors.initials: BY
authors.lastname: Alekseev
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D051340:Cofilin 2 / Q000097:blood / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007610:Kallikreins / Q000097:blood / Q000235:genetics; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D060787:Neoplasm Grading; D017430:Prostate-Specific Antigen / Q000097:blood / Q000235:genetics; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012680:Sensitivity and Specificity; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; C495815:CFL2 protein, human; D051340:Cofilin 2; C549214:MIRN19A microRNA, human; C000613758:MIRN297 microRNA, human; D035683:MicroRNAs; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: blood plasma; little invasive diagnosis; miRNA; prostate cancer