title: Biodegradable and biocompatible high elastic chitosan scaffold is cell-friendly both in vitro and in vivo.
abstract: Biodegradable and biocompatible macromolecule chitosan has been favored for a variety of clinical applications. We reported herein the fabrication of a novel chitosan scaffold with high elasticity. This scaffold can be easily compressed and thus enable the insertion of such scaffold into surgical lesions during minimal invasive surgeries. In addition, this novel scaffold can restore its shape when released. We evidenced that this high elastic scaffold has better biocompatibility than traditional chitosan scaffold. Therefore, this new chitosan material might lead to the manufacture of a variety of novel biodegradable biomedical materials and devices.
authors.affiliation: Department of Polymer Science and Engineering,MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China.
authors.forename: Yichuan
authors.initials: Y
authors.lastname: Pang
authors.affiliation: Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: An
authors.initials: A
authors.lastname: Qin
authors.affiliation: Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Polymer Science and Engineering,MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Polymer Science and Engineering,MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China.
authors.forename: Zhengke
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Shengyun
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jiying
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Shunwu
authors.initials: S
authors.lastname: Fan
authors.affiliation: Department of Polymer Science and Engineering,MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Hu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002454:Cell Differentiation; D002460:Cell Line; D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry; D004548:Elasticity; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis; D011817:Rabbits; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D048271:Chitosan
keywords: chitosan; elastic scaffold; osteogenesis; tissue engineering