title: Safety and Efficacy Evaluation of Pulsed Dye Laser Treatment, CO2Ablative Fractional Resurfacing, and Combined Treatment for Surgical Scar Clearance.
abstract: OBJECTIVE
  Surgical scars are an unwanted sequela following surgical procedures. Several different treatment modalities and approaches are currently being employed to improve the cosmesis of surgical scars with each having varying degrees of success. The objective of this study was to assess the ef cacy and safety pulsed dye laser treatment, CO2 ablative fractional resurfacing, and a combined treatment with these two modalities for the cosmetic improvement of surgical scarring that occurred following the surgical removal of skin cancer from different anatomic areas.
  
  
  METHODS
  Twenty-five patients with surgical scarring most frequently on the face following recent surgical excision of skin cancer with Mohs surgery were included in this multicenter, prospective clinical study. Patients were randomized into 4 treatment arms, namely, pulsed dye laser alone, CO2 laser alone, a combined treatment with these two modalities, and CO2 ablative fractional resurfacing on the same day of surgery to half of the scar, followed by a combined treatment with the two modalities to that half of the scar. Patients in each study arm received a total of 3-4 treatments, while those patients in Arm 4 underwent an additional treatment with CO2 laser immediately after surgery. Patients were followed up at 1 and 3 months after the final treatment session.
  
  
  RESULTS
  No adverse events were seen. Significant improvements in the appearance of scars were achieved in all study arms, as as- sessed by the Vancouver Scar Scale and Global Evaluation Response scales, with the best clinical outcomes seen in those scars that underwent a combination treatment. All patients reported very high satisfaction from treatment.
  
  
  CONCLUSIONS
  Both pulsed dye laser treatment and CO2 ablative fractional resurfacing, when used as a monotherapy, are safe and effective in the treatment and improvement of recent surgical scarring. When both of these modalities are used in combination, however, they appear to potentially have a synergistic effect and an accelerated outcome on the cosmesis of recent surgical scars. <em>J Drugs Dermatol. 2016;15(11):1315-1319.</em>.
authors.forename: Joel L
authors.initials: JL
authors.lastname: Cohen
authors.forename: Roy
authors.initials: R
authors.lastname: Geronemus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002921:Cicatrix / Q000175:diagnosis / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods / Q000592:standards; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D054025:Lasers, Dye / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D054020:Lasers, Gas / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery / Q000009:adverse effects; D011446:Prospective Studies; D000072836:Surgical Wound / Q000175:diagnosis / Q000532:radiotherapy*; D016896:Treatment Outcome