title: PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.
abstract: We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.
authors.affiliation: a Max Planck Institute for Molecular Genetics , Berlin , Germany.
authors.forename: Alisa
authors.initials: A
authors.lastname: Fuchs
authors.affiliation: a Max Planck Institute for Molecular Genetics , Berlin , Germany.
authors.forename: Marcos
authors.initials: M
authors.lastname: Torroba
authors.affiliation: a Max Planck Institute for Molecular Genetics , Berlin , Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kinkley
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D063146:Polycomb-Group Proteins / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D022821:RNA Splice Sites; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; C503048:PHF13 protein, human; D063146:Polycomb-Group Proteins; D022821:RNA Splice Sites; D014157:Transcription Factors; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D012319:RNA Polymerase II
keywords: PHF13; RNA polymerase II; RNA polymerase II pausing; SPOC1; bivalency and H3K4me3; co-transcriptional splicing; polycomb repressive complex 2 (PRC2); transcriptional regulation