title: Carbonic anhydrase inhibitory properties of some uracil derivatives.
abstract: Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4-12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KIvalues of the compounds 4-12 are in the range of 0.085-428 µM for hCA I and of 0.1715-645 µM against hCA II, respectively. It is concluded from the kinetic investigations, all compounds used in the study act as competitive inhibitors with substrate, 4-NPA. Uracil derivatives are emerging agents for the inhibiton of carbonic anhydrase which could be used in biomedicine.
authors.affiliation: a Department of Pharmaceutical Technology , Agri Ibrahim Cecen University , Agri , Turkey.
authors.forename: Emir
authors.initials: E
authors.lastname: Alper Türkoğlu
authors.affiliation: b Department of Chemistry , Agri Ibrahim Cecen University , Agri , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Şentürk
authors.affiliation: c Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica , Sesto Fiorentino , Florence , Italy.
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.affiliation: d Department of Agricultural Biotechnology , Ondokuz Mayis University , Samsun , Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Ekinci
mesh_terms: D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000097:blood / Q000302:isolation & purification; D002846:Chromatography, Affinity; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000302:isolation & purification; D014498:Uracil / Q000494:pharmacology*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D014498:Uracil; D002256:Carbonic Anhydrases
keywords: Carbonic anhydrase; hydroxyl; inhibitor; uracil derivatives