title: Muscle synergies after stroke are correlated with perilesional high gamma.
abstract: Movements can be factored into modules termed "muscle synergies". After stroke, abnormal synergies are linked to impaired movements; however, their neural basis is not understood. In a single subject, we examined how electrocorticography signals from the perilesional cortex were associated with synergies. The measured synergies contained a mix of both normal and abnormal patterns and were remarkably similar to those described in past work. Interestingly, we found that both normal and abnormal synergies were correlated with perilesional high gamma. Given the link between high gamma and cortical spiking, our results suggest that perilesional spiking may organize synergies after stroke.
authors.affiliation: Department of Neurology University of California, San Francisco San Francisco California 94143; San Francisco VA Medical Center San Francisco CA 94121.
authors.forename: Jason
authors.initials: J
authors.lastname: Godlove
authors.affiliation: Department of Neurology University of California, San Francisco San Francisco California 94143; San Francisco VA Medical Center San Francisco CA 94121.
authors.forename: Tanuj
authors.initials: T
authors.lastname: Gulati
authors.affiliation: Departments of Neurological Surgery and Physiology University of California, San Francisco San Francisco California 94143; Center for Integrative Neuroscience University of California, San Francisco San Francisco California 94158.
authors.forename: Ben
authors.initials: B
authors.lastname: Dichter
authors.affiliation: Departments of Neurological Surgery and Physiology University of California, San Francisco San Francisco California 94143; Center for Integrative Neuroscience University of California, San Francisco San Francisco California 94158.
authors.forename: Edward
authors.initials: E
authors.lastname: Chang
authors.affiliation: Department of Neurology University of California, San Francisco San Francisco California 94143; San Francisco VA Medical Center San Francisco CA 94121.
authors.forename: Karunesh
authors.initials: K
authors.lastname: Ganguly