title: A metaplasticity view of the interaction between homeostatic and Hebbian plasticity.
abstract: Hebbian and homeostatic plasticity are two major forms of plasticity in the nervous system: Hebbian plasticity provides a synaptic basis for associative learning, whereas homeostatic plasticity serves to stabilize network activity. While achieving seemingly very different goals, these two types of plasticity interact functionally through overlapping elements in their respective mechanisms. Here, we review studies conducted in the mammalian central nervous system, summarize known circuit and molecular mechanisms of homeostatic plasticity, and compare these mechanisms with those that mediate Hebbian plasticity. We end with a discussion of 'local' homeostatic plasticity and the potential role of local homeostatic plasticity as a form of metaplasticity that modulates a neuron's future capacity for Hebbian plasticity.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
authors.affiliation: Departments of Neurosurgery, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA.
authors.forename: Ada X
authors.initials: AX
authors.lastname: Yee
authors.affiliation: Departments of Neurosurgery, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA.
authors.forename: Yu-Tien
authors.initials: YT
authors.lastname: Hsu
authors.affiliation: Departments of Neurosurgery, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA luchen1@stanford.edu.
authors.forename: Lu
authors.identifier: 0000-0002-8097-2699
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D006706:Homeostasis; D008322:Mammals; D009473:Neuronal Plasticity; D013569:Synapses / Q000502:physiology*
keywords: Hebbian plasticity; homeostatic plasticity; metaplasticity; retinoic acid