title: Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative.
abstract: Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungusEpicoccum nigrum(strain 749) was found to produce the azaphilonoid compounds acetosellin and 5',6'-dihydroxyacetosellin. The latter is a new natural product. The biosynthesis of these polyketide-type compounds is intriguing, since two polyketide chains are assembled to the final product. Here we performed13C labeling studies on solid cultures to prove this hypothesis for acetosellin biosynthesis.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Hufendiek
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Simon Stephan Martin
authors.initials: SSM
authors.lastname: Stölben
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Merten
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Harms
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Max
authors.initials: M
authors.lastname: Crüsemann
authors.affiliation: Biomedical Engineering, Pamukkale University, Denizli, Turkey.
authors.forename: Idris
authors.initials: I
authors.lastname: Arslan
authors.affiliation: Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Gütschow
authors.affiliation: Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), Pharmaceutical Microbiology Unit, University of Bonn, Bonn, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Schneider
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Gabriele Maria
authors.initials: GM
authors.lastname: König
mesh_terms: D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism; D002247:Carbon Isotopes / Q000032:analysis; D055808:Drug Discovery; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry* / Q000378:metabolism
chemical_list: C000625850:5',6'-dihydroxyacetosellin; D001688:Biological Products; D002247:Carbon Isotopes; D061065:Polyketides; C000625849:acetosellin