title: Determinants of Serum Glycerophospholipid Fatty Acids in Cystic Fibrosis.
abstract: The etiology of altered blood fatty acid (FA) composition in cystic fibrosis (CF) is understood only partially. We aimed to investigate the determinants of serum glycerophospholipids' FAs in CF with regard to the highest number of FAs and in the largest cohort to date. The study comprised 172 CF patients and 30 healthy subjects (HS). We assessed Fas' profile (gas chromatography/mass spectrometry), CF transmembrane conductance regulator (CFTR) genotype, spirometry, fecal elastase-1, body height and weightZ-scores, liver disease, diabetes and colonization byPseudomonas aeruginosa. The amounts of saturated FAs (C14:0, C16:0) and monounsaturated FAs (C16:1n-7, C18:1n-9, C20:1n-9, C20:3n-9) were significantly higher in CF patients than in HS. C18:3n-6, C20:3n-6 and C22:4n-6 levels were also higher in CF, but C18:2n-6, C20:2n-6 and C20:4n-6, as well as C22:6n-3, were lower. In a multiple regression analysis, levels of seven FAs were predicted by various sets of factors that included age, genotype, forced expiratory volume in one second, pancreatic status and diabetes. FA composition abnormalities are highly prevalent in CF patients. They seem to be caused by both metabolic disturbances and independent clinical risk factors. Further research into the influence ofCFTRmutations on fat metabolism and desaturases' activity is warranted.
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznań, Poland. slawomiradrzymala@wp.pl.
authors.forename: Sławomira
authors.initials: S
authors.lastname: Drzymała-Czyż
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznań, Poland. p.krzyzanowska@tlen.pl.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Krzyżanowska
authors.affiliation: Ludwig-Maximilians-Universität München, Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Lindwurmstr. 4, D-80337 Munich, Germany. office.koletzko@med.lmu.de.
authors.forename: Berthold
authors.initials: B
authors.lastname: Koletzko
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznań, Poland. j-nowak@outlook.com.
authors.forename: Jan
authors.initials: J
authors.lastname: Nowak
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznań, Poland. mucha604@interia.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Miśkiewicz-Chotnicka
authors.affiliation: Department of Computer Science and Statistics, Poznan University of Medical Sciences, Dąbrowskiego 79, 60-529 Poznań, Poland. jmoczko@ump.edu.pl.
authors.forename: Jerzy A
authors.initials: JA
authors.lastname: Moczko
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznań, Poland. alisow1@wp.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznań, Poland. jarwalk@ump.edu.pl.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000097:blood*; D003710:Demography; D004032:Diet; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D020404:Glycerophospholipids / Q000097:blood*; D006801:Humans; D008297:Male; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D005227:Fatty Acids; D020404:Glycerophospholipids
keywords: arachidonic acid; docosahexaenoic acid; eicosapentaenoic acid; phospholipids; polyunsaturated fatty acid