title: Relationship between mean platelet volume and ischemic stroke in patients with patent foramen ovale.
abstract: OBJECTIVE
  Patent foramen ovale (PFO) is commonly encountered in patients with cryptogenic stroke. Mean platelet volume (MPV), an indicator of platelet reactivity, has been reported in recent trials to be higher in patients with PFO than in normal population. The aim of this study was to investigate whether there is a difference in MPV between patients with PFO and stroke or transient ischemic attack (TIA) and that of patients with asymptomatic PFO.
  
  
  METHODS
  Patients with PFO who were younger than 55 years of age were enrolled in this retrospective study. Hemogram parameters of patients with ischemic stroke or TIA (symptomatic group) were obtained during hospitalization once they had stable clinical status.
  
  
  RESULTS
  Total of 108 patients, 51 of whom were symptomatic, were included in the study. MPV was determined to be higher in symptomatic group compared with asymptomatic group (median 10.0 fl [25th-75th percentile: 9.0-11.0] vs median 8.56 fl [25th-75th percentile: 8.0-9.0], respectively; p<0.001,. Cut-off point of 9.0 fl for MPV had 70% sensitivity and 86% specificity in predicting symptomatic PFO patients.
  
  
  CONCLUSIONS
  MPV is higher in symptomatic than in asymptomatic PFO patients. This finding may be a subsidiary risk factor to identify patients with PFO and high risk of cardioembolic stroke.
authors.affiliation: Department of Cardiology, Antalya Training and Research Hospital, Antalya, Turkey. dr.nermin@mynet.com.
authors.forename: Nermin
authors.initials: N
authors.lastname: Bayar
authors.forename: Selçuk
authors.initials: S
authors.lastname: Küçükseymen
authors.forename: Zehra
authors.initials: Z
authors.lastname: Erkal
authors.forename: Ramazan
authors.initials: R
authors.lastname: Güven
authors.forename: Erkan
authors.initials: E
authors.lastname: Köklü
authors.forename: Çağın Mustafa
authors.initials: ÇM
authors.lastname: Üreyen
authors.forename: Şakir
authors.initials: Ş
authors.lastname: Arslan
mesh_terms: D000328:Adult; D005260:Female; D054092:Foramen Ovale, Patent / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors