title: Adipocyte and epidermal fatty acid-binding protein serum concentrations in patients with lipodystrophy.
abstract: Lipodystrophy (LD) syndromes are associated with diabetes mellitus, hypertriglyceridemia, and coronary artery disease. One pathogenetic factor of LD is dysregulation of several adipokines. However, the insulin resistance- and dyslipidemia-promoting adipokines adipocyte (AFABP) and epidermal (EFABP) fatty acid-binding protein have not been investigated in non-HIV-associated LD so far.
  
  
  
  We performed a cross-sectional analysis of AFABP and EFABP serum concentrations in 37 LD patients and 37 age-, gender-, and body mass index-matched healthy controls. Moreover, AFABP and EFABP were correlated to clinical and biochemical parameters of inflammation, glucose control, and lipid metabolism.
  
  
  
  There was no significant difference in median circulating AFABP and EFABP levels between LD patients (21.7μg/l and 7.5μg/l, respectively) and healthy controls (24.5μg/l and 8.6μg/l, respectively). Neither AFABP nor EFABP were related to markers of impaired glucose control or lipid metabolism. Multiple linear regression analysis showed a positive and independent association of AFABP with gender, serum leptin levels, and body mass index.
  
  
  
  Circulating levels of AFABP and EFABP are not decreased in LD despite adipose tissue loss in contrast to other adipokines including leptin and adiponectin.
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany. Electronic address: konstanze.miehle@medizin.uni-leipzig.de.
authors.forename: Konstanze
authors.initials: K
authors.lastname: Miehle
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, Leipzig, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebert
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, Leipzig, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany.
authors.forename: Annett
authors.initials: A
authors.lastname: Hoffmann
authors.affiliation: Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany.
authors.forename: Haiko
authors.initials: H
authors.lastname: Schlögl
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, Leipzig, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; C493412:FABP5 protein, human; D050556:Fatty Acid-Binding Proteins
keywords: Adipocyte fatty acid-binding protein; Diabetes mellitus; Epidermal fatty acid-binding protein; Insulin resistance; Lipodystrophy; Obesity