title: A case of anaplastic lymphoma kinase (ALK)-positive ciliated muconodular papillary tumor (CMPT) of the lung.
abstract: Ciliated muconodular papillary tumor (CMPT) is a rare papillary tumor that arises in the peripheral lung fields and is associated with the proliferation of ciliate d and goblet cells and increased mucin production. We report a case of CMPT involving the rearrangement of the anaplastic lymphoma kinase (ALK) gene. The patient was an 84-year-old Japanese female who had exhibited a small nodular shadow on chest computed tomography during a regular checkup 10 years ago. She underwent a partial resection of segment S10 of the right lung. The cut surface of the surgical specimen revealed a well-circumscribed, jelly-like mass measuring 8 × 8 × 10 mm. Histologically, the tumor was composed of a mixture of ciliated, goblet, and basal cells arranged in a papillary pattern together with pools of mucin. A diagnosis of CMPT was made. The lung tumor cells were subjected to fluorescent in situ hybridization and highly sensitive immunohistochemical staining for the ALK protein, both of which produced positive results. CMPT usually follows a favorable course, but the exact nature of this tumor; i.e., whether it is benign or malignant, has not been established. This is the first reported case of an ALK-positive CMPT.
authors.affiliation: Department of Surgery, Aizawa Hospital, Matsumoto, Japan.|Department of Thoracic Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Taguchi
authors.affiliation: Department of Anatomic Pathology, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Higuchi
authors.affiliation: Department of Anatomic Pathology, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Sudo
authors.affiliation: Department of Surgery, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Misawa
authors.affiliation: Department of Surgery, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyamoto
authors.affiliation: Department of Surgery, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Mishima
authors.affiliation: Department of Surgery, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Morihisa
authors.initials: M
authors.lastname: Kitano
authors.affiliation: Department of Anatomic Pathology, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Azuhata
authors.affiliation: Department of Anatomic Pathology, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Ito
mesh_terms: D000369:Aged, 80 and over; D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology*; D005260:Female; D020397:Goblet Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D009077:Mucins; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: ALK (anaplastic lymphoma kinase) gene; CMPT (ciliated muconodular papillary tumor); lung