title: Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer's Disease Risk.
abstract: Background: Alzheimer's disease (AD) is a significant public health issue. AD has been linked with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, but the findings have been inconsistent. The purpose of this meta-predictive analysis is to examine the associations betweenMTHFRpolymorphisms and epigenetic factors, including air pollution, with AD risk using big data analytics approaches.Methods and Results: Forty-three studies (44 groups) were identified by searching various databases.MTHFRC677T TT and CT genotypes had significant associations with AD risk in all racial populations (RR = 1.13,p= 0.0047; and RR = 1.12,p< 0.0001 respectively). Meta-predictive analysis showed significant increases of percentages ofMTHFRC677T polymorphism with increased air pollution levels in both AD case group and control group (p= 0.0021-0.0457); with higher percentages of TT and CT genotypes in the AD case group than that in the control group with increased air pollution levels.Conclusions: The impact ofMTHFRC677T polymorphism on susceptibility to AD was modified by level of air pollution. Future studies are needed to further examine the effects of gene-environment interactions including air pollution on AD risk for world populations.
authors.affiliation: Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan. suhmian500@gmail.com.|Graduate Institute of Clinical Medical Sciences, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan. suhmian500@gmail.com.
authors.forename: Suh-Mian
authors.initials: SM
authors.lastname: Wu
authors.affiliation: Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan. suhmian@mail.ypu.edu.tw.
authors.forename: Zhao-Feng
authors.initials: ZF
authors.lastname: Chen
authors.affiliation: College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA. luyoung@augusta.edu.
authors.forename: Lufei
authors.initials: L
authors.lastname: Young
authors.affiliation: College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA. pshiao@augusta.edu.
authors.forename: S Pamela K
authors.initials: SP
authors.lastname: Shiao
mesh_terms: D000397:Air Pollution / Q000032:analysis*; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Alzheimer’s disease; meta-analysis; methylenetetrahydrofolate reductase gene