title: The Correlation Between a Short-term Conventional Electroencephalography in the First Day of Life and Brain Magnetic Resonance Imaging in Newborns Undergoing Hypothermia for Hypoxic-Ischemic Encephalopathy.
abstract: Electroencephalograph recorded in the first day of life in newborns treated with hypothermia for hypoxic-ischemic encephalopathy could be utilized as a predictive tool for the severity of brain injury on magnetic resonance imaging and mortality.
  
  
  
  We analyzed newborns who were admitted for therapeutic hypothermia due to hypoxic-ischemic encephalopathy. All enrolled infants underwent encephalography within the first 24 hours of life and underwent brain magnetic resonance imaging after rewarming. All encephalographs were independently reviewed for background amplitude, continuity, and variability. Brain injury determined by magnetic resonance imaging was scored using methods described by Bonifacio et al.
  
  
  
  Forty-one newborns were included in the study. Each encephalograph variable correlated significantly with the severity of injury on brain magnetic resonance imaging (P < 0.001 for each). The overall encephalograph severity estimated as mild, moderate, and severe also correlated with injury (P < 0.001). Each encephalograph variable correlated with mortality (P < 0.001 for each) and also the overall encephalograph severity (P < 0.001).
  
  
  
  Severity of electrographic findings on encephalograph in the first day of life during therapeutic hypothermia for hypoxic-ischemic encephalopathy correlated with the extent of injury on brain magnetic resonance imaging. This information may be useful for families and aid guide clinical decision making.
authors.affiliation: Department of Neurology, Children's National Health System, Washington, District of Columbia. Electronic address: rawad.obeid@hotmail.com.
authors.forename: Rawad
authors.initials: R
authors.lastname: Obeid
authors.affiliation: Division of Pediatric Neurology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: yoshimi.sogawa@chp.edu.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Sogawa
authors.affiliation: Division of Pediatric Neurology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Satyanarayana
authors.initials: S
authors.lastname: Gedela
authors.affiliation: Division of Pediatric Neurology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Monica
authors.initials: M
authors.lastname: Naik
authors.affiliation: Division of Pediatric Radiology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Vince
authors.initials: V
authors.lastname: Lee
authors.affiliation: Division of Newborn Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Richard
authors.initials: R
authors.lastname: Telesco
authors.affiliation: Department of Radiology, Children's Hospital of Los Angeles, Los Angeles, California.
authors.forename: Jessica
authors.initials: J
authors.lastname: Wisnowski
authors.affiliation: Division of Pediatric Neurology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Christine
authors.initials: C
authors.lastname: Magill
authors.affiliation: Division of Pediatric Neurology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Painter
authors.affiliation: Division of Pediatric Radiology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Ashok
authors.initials: A
authors.lastname: Panigrahy
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: EEG; HIE; MRI; neonatal intensive care; neuroprotection; newborns; whole body cooling