title: Skeletal muscle aging: influence of oxidative stress and physical exercise.
abstract: Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations.
authors.affiliation: Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil.
authors.forename: Mariana Janini
authors.initials: MJ
authors.lastname: Gomes
authors.affiliation: School of Physical Therapy, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
authors.forename: Paula Felippe
authors.initials: PF
authors.lastname: Martinez
authors.affiliation: Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil.
authors.forename: Luana Urbano
authors.initials: LU
authors.lastname: Pagan
authors.affiliation: Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil.
authors.forename: Ricardo Luiz
authors.initials: RL
authors.lastname: Damatto
authors.affiliation: Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil.
authors.forename: Marcelo Diacardia Mariano
authors.initials: MDM
authors.lastname: Cezar
authors.affiliation: Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil.
authors.forename: Aline Regina Ruiz
authors.initials: ARR
authors.lastname: Lima
authors.affiliation: Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil.
authors.forename: Katashi
authors.initials: K
authors.lastname: Okoshi
authors.affiliation: Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil.
authors.forename: Marina Politi
authors.initials: MP
authors.lastname: Okoshi
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology* / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*
keywords: elderly; physical capacity; sarcopenia; training; treatment