title: The Lack of Association between FCN2 Gene Promoter Region Polymorphisms and Dental Caries in Polish Children.
abstract: The aim of this study was to examine the association of single-nucleotide polymorphisms (SNPs) in the gene encoding ficolin-2 protein (FCN2 gene) at positions -986 (rs17514136), -602 (rs3124953), and -4 (rs3124952) with dental caries in Polish children. Two hundred and sixty Polish Caucasian children aged 15 years were enrolled in this study: 82 with "higher" caries experience (DMFT >5) and 178 with "lower" caries experience (DMFT ≤5). In addition, subjects with caries experience (DMFT ≥1) and caries-free subjects (DMFT = 0) were compared. FCN2 SNPs were genotyped with PCR-RFLP methods. There were no significant differences in the genotype, allele, or haplotype distributions in 3 analyzed SNPs of the FCN2 gene between children with "higher" and those with "lower" caries experience as well as between children with caries experience and caries-free children. In conclusion, we did not find any association of FCN2 promoter polymorphisms at positions -986, -602, and -4 with dental caries in Polish children.
authors.affiliation: Department of Hygiene and Epidemiology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Olszowski
authors.forename: M
authors.initials: M
authors.lastname: Milona
authors.forename: J
authors.initials: J
authors.lastname: Janiszewska-Olszowska
authors.forename: K
authors.initials: K
authors.lastname: Safranow
authors.forename: K
authors.initials: K
authors.lastname: Skonieczna-Żydecka
authors.forename: A
authors.initials: A
authors.lastname: Walczak
authors.forename: M
authors.initials: M
authors.lastname: Sikora
authors.forename: D
authors.initials: D
authors.lastname: Chlubek
authors.forename: A
authors.initials: A
authors.lastname: Madlani
authors.forename: G
authors.initials: G
authors.lastname: Adler
mesh_terms: D000293:Adolescent; D000483:Alleles; D004245:DMF Index; D003731:Dental Caries / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D060005:Genotyping Techniques; D006239:Haplotypes; D006801:Humans; D037102:Lectins / Q000235:genetics*; D008297:Male; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D000097604:Ficolins
chemical_list: D037102:Lectins; D000097604:Ficolins