title: The impact of Zika virus in the brain.
abstract: The recent outbreak of ZIKV in Brazil called the attention of the world because the effects of viral infection in the brain under development in fetuses. Consequences of vertical infection comprise brain malformation, especially microcephaly, eye and musculoskeletal abnormalities, among others. In adults, outcomes of infection include meningoencephalitis and Guillain-Barré Syndrome. Recent data specific suggest that neural progenitor cells are the main targets of ZIKV infection, causing massive cellular death and impairment in the neurogenesis process. Here we review the fetal and adult brain damage after ZIKV exposure, exploring models to study the mechanisms underlying the pathways related to microcephaly and cell death.
authors.affiliation: University of São Paulo, Department of Surgery, Stem Cell Laboratory, São Paulo, São Paulo, 05508-270, Brazil.
authors.forename: Fabiele Baldino
authors.initials: FB
authors.lastname: Russo
authors.affiliation: University of São Paulo, Department of Surgery, Stem Cell Laboratory, São Paulo, São Paulo, 05508-270, Brazil; School of Arts Sciences and Humanities, Department of Obstetrics, São Paulo, SP, 03828-000, Brazil. Electronic address: patriciacbbbraga@usp.br.
authors.forename: Patricia Cristina Baleeiro
authors.initials: PCB
authors.lastname: Beltrão-Braga
mesh_terms: D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000473:pathology / Q000821:virology*; D018792:Encephalitis, Viral / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D058953:Neural Stem Cells / Q000473:pathology / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000821:virology*; D000071244:Zika Virus / Q000502:physiology*; D000071243:Zika Virus Infection / Q000473:pathology / Q000821:virology*
keywords: Brain damage; Flavivirus; Microcephaly; Neuroprogenitor cells; ZIKV; Zika