title: Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites.
abstract: Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory-secretory (ES) products from Hp directly suppress osteoclast differentiation in vitro. Taken together, these results demonstrate that helminth infections can dampen autoimmune diseases and highlight a previously unrecognized and important role for ES products, by directly impacting on bone destruction.
authors.affiliation: a Interdisciplinary Center for Clinical Research Laboratory (IZKF Würzburg), Department of Internal Medicine II, University of Würzburg , Würzburg , Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Sarter
authors.affiliation: b Ecole Polytechnique Fédérale de Lausanne (EPFL), Global Health Institute , Lausanne , Switzerland , and.
authors.forename: Manuel
authors.initials: M
authors.lastname: Kulagin
authors.affiliation: c Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen , Erlangen , Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Schett
authors.affiliation: b Ecole Polytechnique Fédérale de Lausanne (EPFL), Global Health Institute , Lausanne , Switzerland , and.
authors.forename: Nicola L
authors.initials: NL
authors.lastname: Harris
authors.affiliation: b Ecole Polytechnique Fédérale de Lausanne (EPFL), Global Health Institute , Lausanne , Switzerland , and.|c Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen , Erlangen , Germany.
authors.forename: Mario M
authors.initials: MM
authors.lastname: Zaiss
mesh_terms: D000818:Animals; D001168:Arthritis / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D001169:Arthritis, Experimental; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001862:Bone Resorption / Q000150:complications* / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D002454:Cell Differentiation; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D004195:Disease Models, Animal; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000276:immunology / Q000469:parasitology*; D006373:Helminthiasis / Q000150:complications* / Q000276:immunology / Q000469:parasitology*; D008297:Male; D051379:Mice; D009351:Nematospiroides dubius; D010010:Osteoclasts / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D016207:Cytokines
keywords: Arthritis; bone metabolism; excretory–secretory products; helminths; osteoclast