title: Hyperventilation with Maintenance of Isocapnia. An "Old New" Method in Carbon Monoxide Intoxication.
abstract: BACKGROUND
  Exposure to carbon monoxide (CO) is among the most common causes of acute and chronic poisonings worldwide. The crucial point of treatment of such acute poisonings is to eliminate CO from the body as fast as possible. There are currently two approaches to the management of the CO intoxication: hyperbaric oxygen therapy (HOT) and normobaric oxygen therapy (NOT). HOT is highly effective and capable of achieving the CO elimination half-time (T½) as low as 15 minutes. Unfortunately this method is expensive and not always readily available. The elimination of CO with the use of NOT (T½~70 min) is slower, but treatment can be started even on the site of the exposure and continued while the patient is transported to a hospital. The aim of the study was to evaluate the effectiveness of a method using therapeutic hyperventilation with maintenance of isocapnia (IH) in the elimination of CO in volunteers exposed to CO and to compare selected gasometric and respiratory parameters during IH with the values obtained during hyperventilation with pure oxygen ("non-isocapnic hyperventilation"-NIH).
  
  
  METHODS
  The study involved 13 healthy, chronically-smoking volunteers. Each of them participated in two independent hyperventilation tests: IH and NIH. The levels of carboxyhemoglobin (COHb) and selected gasometric, cardiac and respiratory parameters were measured at 0, 10 and 20 minutes during both tests. Among 13 volunteers (8 women and 5 men) the initial COHb level was 5.0±1.5% (mean±SD) before the IH tests and 5.1±1.9% before the NIH tests (p>0.05). After 20 minutes of the procedures the mean COHb level was 2.9±0.9% for IH and 3.6±1.2% for NIH (p<0.01). The T½ of COHb was 29.6±12.2 min and 47.3±19.2 min respectively (p<0.01). After 10 minutes of NIH respiratory alkalosis was noted in 11 participants (84.6%). Such problem was not seen during the IH procedures. No serious adverse effects were recorded during either IH or NIH. Mild symptoms such as: dyspnea, headache and paresthesias were reported by 6 volunteers (46%) during both IH and NIH tests. It is worth noting that paresthesias were only reported during NIH, by 2 participants (15.4%).
  
  
  CONCLUSIONS
  The elimination T½ of CO during IH was comparable with the values reported during HOT, and lower than can be achieved with NOT or NIH. No serious adverse effects were reported during IH procedures. Further studies, especially direct comparisons with NOT and HOT, are necessary to evaluate the effectiveness of IH in the treatment of acute CO poisoning.
authors.affiliation: Department of Clinical Toxicology, Medical University of Gdańsk, Gdańsk, Poland.|Pomeranian Centre of Toxicology, Gdańsk, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Sein Anand
authors.affiliation: Department of Clinical Toxicology, Medical University of Gdańsk, Gdańsk, Poland.|Pomeranian Centre of Toxicology, Gdańsk, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Schetz
authors.affiliation: Department of Clinical Toxicology, Medical University of Gdańsk, Gdańsk, Poland.|Pomeranian Centre of Toxicology, Gdańsk, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Waldman
authors.affiliation: Department of Clinical Toxicology, Medical University of Gdańsk, Gdańsk, Poland.|Pomeranian Centre of Toxicology, Gdańsk, Poland.
authors.forename: Marek
authors.identifier: http://orcid.org/0000-0002-7689-1626
authors.initials: M
authors.lastname: Wiśniewski
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000627:therapeutic use; D002248:Carbon Monoxide / Q000097:blood; D002249:Carbon Monoxide Poisoning / Q000628:therapy*; D002263:Carboxyhemoglobin / Q000032:analysis; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
chemical_list: D002245:Carbon Dioxide; D002248:Carbon Monoxide; C011700:carbogen; D002263:Carboxyhemoglobin; D010100:Oxygen