title: Plasma 25-Hydroxyvitamin D3Levels in Colorectal Cancer Patients and Associations with Physical Activity.
abstract: Physical activity (PA) and vitamin D are thought to affect colorectal cancer prognosis. The present study investigates associations between 25(OH)D3and PA in prospectively followed colorectal cancer patients in the ColoCare study. At 6, 12, and 24 mo after surgery, patients donated a blood sample, wore an accelerometer for 10 consecutive days, and completed a PA questionnaire. Plasma 25-hydroxyvitamin D3(25(OH)D3) levels were measured by high-performance liquid chromatography. We tested associations using partial correlations and multivariate linear regression analysis, adjusted for season, age, and body mass index. A total of 137 assessments of 25(OH)D3levels and PA were conducted (58 at 6 mo, 51 at 12 mo, and 28 at 24 mo). More than 60% of the patients were vitamin D-deficient (25(OH)D3≤20 ng/ml), independent of study time point. At 6-mo follow-up, accelerometry-based vigorous and moderate-to-vigorous PAs were positively associated with 25(OH)D3levels (P = 0.04; P = 0.006,). PA together with season was a significant predictor of elevated 25(OH)D3levels. Our results suggest that the majority of colorectal cancer patients may suffer from vitamin D deficiency. Engaging in PA may be an effective approach to increase their 25(OH)D3levels.
authors.affiliation: a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Skender
authors.affiliation: a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.|b Huntsman Cancer Institute , Salt Lake City , Utah , USA.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Böhm
authors.affiliation: a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Schrotz-King
authors.affiliation: c Division of Clinical Epidemiology , German Cancer Research Center (DKFZ) , Heidelberg Germany.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.affiliation: d Department of Cancer Epidemiology , H. Lee Moffitt Cancer Center and Research Institute , Tampa , Florida , USA.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Siegel
authors.affiliation: a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.
authors.forename: Karen
authors.initials: K
authors.lastname: Steindorf
authors.affiliation: a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Owen
authors.affiliation: b Huntsman Cancer Institute , Salt Lake City , Utah , USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ose
authors.affiliation: e Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) , Heidelberg , Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Hoffmeister
authors.affiliation: a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.|e Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) , Heidelberg , Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
authors.affiliation: a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.|b Huntsman Cancer Institute , Salt Lake City , Utah , USA.|f Fred Hutchinson Cancer Research Center , Seattle , Washington , USA.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Ulrich
mesh_terms: D061725:Accelerometry; D000368:Aged; D002112:Calcifediol / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D002112:Calcifediol