title: The Association of Serum 25-Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients With Sickle Cell Disease.
abstract: Although vitamin D deficiency (VDD) has been linked to anemia among sickle cell disease (SCD), its relationship with hemolysis is unclear. Serum 25-hydroxyvitamin D and biomarkers of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage, absolute reticulocyte, and lactate dehydrogenase [LDH] levels) in 36 hydroxyurea-naive SCD children were quantified. Correlations were significantly positive with Hb/hematocrit (r=0.40, P=0.017; r=0.45, P=0.006, respectively); inverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0.44, P=0.008; r=-0.47, P=0.007; r=-0.45, P=0.007, respectively). In VDD groups, Hb was lower (P=0.014), reticulocyte counts and LDH were higher (P=0.047 and 0.003, respectively). Serum 25-hydroxyvitamin D correlated with biomarkers of hemolysis in SCD and VDD may play a role in SCD pathogenesis.
authors.affiliation: Haematology and Blood Transfusion Division, Escola Paulista de Medicina.|Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Adegoke
authors.affiliation: Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
authors.forename: Josefina A P
authors.initials: JAP
authors.lastname: Braga
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Kuwait University, Kuwait.
authors.forename: Adekunle D
authors.initials: AD
authors.lastname: Adekile
authors.affiliation: Haematology and Blood Transfusion Division, Escola Paulista de Medicina.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Figueiredo
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006461:Hemolysis; D006801:Humans; D008297:Male; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D