title: Neuroimmune regulation during intestinal development and homeostasis.
abstract: Interactions between the nervous system and immune system are required for organ function and homeostasis. Evidence suggests that enteric neurons and intestinal immune cells share common regulatory mechanisms and can coordinate their responses to developmental challenges and environmental aggressions. These discoveries shed light on the physiology of system interactions and open novel perspectives for therapy designs that target underappreciated neurological-immunological commonalities. Here we highlight findings that address the importance of neuroimmune cell units (NICUs) in intestinal development, homeostasis and disease.
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Edifício Egas Moniz, Lisboa, Portugal.|Champalimaud Research, Champalimaud Centre for the Unknown, Lisboa, Portugal.
authors.forename: Henrique
authors.identifier: 0000-0001-6216-1836
authors.initials: H
authors.lastname: Veiga-Fernandes
authors.affiliation: The Francis Crick Institute, London, UK.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Pachnis
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007107:Immune System; D007410:Intestinal Diseases / Q000276:immunology* / Q000628:therapy; D007413:Intestinal Mucosa / Q000276:immunology*; D007422:Intestines / Q000196:embryology / Q000276:immunology*; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism; D064307:Microbiota; D009420:Nervous System; D009432:Neural Crest; D055495:Neurogenesis; D009457:Neuroglia / Q000502:physiology; D015213:Neuroimmunomodulation
chemical_list: D016173:Macrophage Colony-Stimulating Factor