title: [Evaluation of the antitumor potential of cerebrolysin].
abstract: OBJECTIVE
  To investigate the effect of cerebrolysin on the growth and metastasis of malignant tumors in mice (a model of lung carcinoma Lewis).
  
  
  METHODS
  The study was performed on 60 male mice, hybrids F1 (the age of 2-2.5 months, body weight 19-22g.). Transplantable epidermoid Lewis lung carcinoma (LLC) was used as a standard experimental model to evaluate the properties of the potential antitumor agents. Experimental animals were administered a single intraperitoneal injection of cerebrolysin in doses of 524 mg/kg (n=20) and 1800 mg/kg (n=20) daily from 2 to 16 days after tumor transplantation.
  
  
  CONCLUSIONS
  Compared with the control group (n=20), cerebrolysin induced growth inhibition of LLC during the treatment (7 to 16 days). An impact of the drug was accompanied by the inhibition of the tumor growth rate by 10-15% (p<0.05). Cerebrolysin demonstrated a dose-dependent effect of reducing the large number of metastases: a number of large metastases significantly decreased by 30-50% with the increase of cerebrolysin dose (p=0.01). Cerebrolysin can significantly suppress the growth rate of Lewis lung carcinoma.
authors.affiliation: Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Gromova
authors.affiliation: Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Pronin
authors.affiliation: Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia, Moscow Institute of physics and technology, Dolgoprudny, Moscow region, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Torshin
authors.affiliation: Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kalacheva
authors.affiliation: Moscow Institute of physics and technology, Dolgoprudny, Moscow region, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Filimonova
authors.affiliation: Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Demidov
authors.affiliation: Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Gogoleva
authors.affiliation: Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: T R
authors.initials: TR
authors.lastname: Grishina
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; C006952:cerebrolysin