title: Relationship between Genetic Polymorphisms with Periodontitis and Peri-Implantitis in the Iranian Population: A Literature Review.
abstract: Periodontitis is an infectious disease of the tooth-supporting tissues. Specific periodontal pathogens trigger inflammatory responses and result in progressive bone loss, which eventually leads to exfoliation of teeth. Periimplantitis is the destructive inflammatory process affecting the soft and hard tissues surrounding dental implants. The periodontal pathogens found around failing implants are very similar to those associated with various forms of periodontal diseases. Genetic susceptibility has been known to be an important risk factor for periodontitis and periimplantitis and there have been numerous studies evaluating this in different populations. Many gene polymorphisms may influence individual susceptibility to periodontitis and peri-implantitis. We conducted a review of the literature for gene polymorphisms associated with periodontitis and peri-implantitis susceptibility in the Iranian population. A comprehensive search of the literature on human studies in English, published from January 2004 to February 2015 in PubMed database and Google scholar was performed using the key words "periodontitis," "peri-implantitis," "gene polymorphisms," and "Iranian population." Sixty-six studies were identified; 33 articles were excluded based on review of titles and abstracts. Thirty articles were eligible and had the full text evaluated. Further studies are needed to get more inclusive perception of the influence of gene polymorphisms in periodontitis and peri-implantitis.
authors.affiliation: Periodontics Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Kadkhodazadeh
authors.affiliation: Periodontics Department, Dental School, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Zahra Alizadeh
authors.initials: ZA
authors.lastname: Tabari
authors.affiliation: Periodontics Department, Dental School, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Tahere
authors.initials: T
authors.lastname: Pourseyediyan
authors.affiliation: Periodontics Department, Dental School, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Kimya
authors.initials: K
authors.lastname: Najafi
authors.affiliation: Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Amid
mesh_terms: D015921:Dental Implants / Q000009:adverse effects*; D006801:Humans; D007492:Iran; D057873:Peri-Implantitis / Q000235:genetics*; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D015921:Dental Implants