title: The serum concentration of soluble interleukin-2 receptor in patients with Kawasaki disease.
abstract: Kawasaki disease is a febrile disease of childhood that is associated with increased inflammatory cytokines and immunoregulatory abnormalities. While the serum concentrations of soluble IL-2 receptor can change under such pathologies, the relevance of the soluble IL-2 receptor concentration in patients with Kawasaki disease has not been specified. We aimed to summarize the existing studies that reported the soluble IL-2 receptor concentrations in patients with Kawasaki disease. Original articles that were published up to July 2016 were collected using a PubMed/Medline-based search engine. A total of nine articles that reported the serum soluble IL-2 receptor concentrations in acute-phase Kawasaki disease were eligible. All of the articles described a high soluble IL-2 receptor concentration in patients with Kawasaki disease relative to the level of controls or the reference range. Two of five articles on patients with coronary artery aneurysms described a significantly higher soluble IL-2 receptor concentration in patients with coronary artery aneurysms than patients without. Two articles on patients with intravenous immunoglobulin therapy described a significant decrease of the soluble IL-2 receptor concentration after the therapy. Accordingly, the serum soluble IL-2 receptor can be a potent marker of disease activity and therapeutic effects in patients with Kawasaki disease; further studies are thus warranted for its use in the clinical setting.
authors.affiliation: 1 Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.|2 Department of Medicine, Iwate Prefectural Senmaya Hospital, Iwate, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Teraura
authors.affiliation: 1 Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.affiliation: 3 Department of Pediatrics, Jichi Medical University, Tochigi, Japan.
authors.forename: Takaomi
authors.initials: T
authors.lastname: Minami
authors.affiliation: 1 Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Takeshima
authors.affiliation: 1 Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.|2 Department of Medicine, Iwate Prefectural Senmaya Hospital, Iwate, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Shimooki
authors.affiliation: 1 Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kajii
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D015870:Gene Expression; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D015375:Receptors, Interleukin-2 / Q000097:blood* / Q000235:genetics; D012995:Solubility
chemical_list: D015415:Biomarkers; D016756:Immunoglobulins, Intravenous; D015375:Receptors, Interleukin-2
keywords: CD25; Interleukin-2; coronary aneurysm; intravenous immunoglobulin therapy; mucocutaneous lymph node syndrome