title: Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance.
abstract: We introduce a model for HIV/AIDS which can be utilized to assess the impact of combining pre-exposure prophylaxis (PrEP) and antiretroviral drugs (ARVs) use interventions (incorporating drug resistance). Mathematical and numerical analyses are carried out to investigate the effects of the combined controls in the presence of PrEP drug resistance. Our results predict a significant decrease in the number of new HIV infections when PrEP and ARVs are concurrently implemented at high levels. The results also reveal that PrEP drug resistance has the potential to slow down or reverse the effects of PrEP, especially at low efficacy levels.
authors.affiliation: School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, South Africa; DST-NRF Center of Excellence in Mathematical and Statistical Sciences (CoE-MaSS), South Africa. Electronic address: komia@aims.ac.za.
authors.forename: Komi
authors.initials: K
authors.lastname: Afassinou
authors.affiliation: School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, South Africa. Electronic address: chirovef@ukzn.ac.za.
authors.forename: Faraimunashe
authors.initials: F
authors.lastname: Chirove
authors.affiliation: School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, South Africa. Electronic address: govinder@ukzn.ac.za.
authors.forename: Keshlan S
authors.initials: KS
authors.lastname: Govinder
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission*; D006801:Humans; D008962:Models, Theoretical; D065129:Pre-Exposure Prophylaxis
chemical_list: D044966:Anti-Retroviral Agents
keywords: Prep awareness; Prep drug resistance; Prep efficacy