title: Synovial chondromatosis of the temporomandibular joint: Immunohistochemical examinations regarding the role of insulin-like growth factors and their binding proteins in the etiology of this disease.
abstract: Synovial chondromatosis (SC) is a benign disease of the joints without a known cause. It sometimes affects the temporomandibular joint (TMJ) and is accompanied by pain, swelling, malocclusion, and crepitation. It has been divided into three stages by Milgram and is supposed to originate from the synovia and cartilage of a joint (Milgram, 1977b). The aim of this study was to examine an involvement of the insulin-like growth factors (IGF-I/-II) and their binding proteins (IGFBP-1 to -6) in the etiology of this disease. Therefore 23 specimen of SC from 16 patients were immunohistochemically stained and microscopically examined. Staining was assessed semiquantitatively: negative (-), weakly positive ((+)), moderately positive (+), strongly positive (++) and very strongly positive (+++). It could be seen that especially the chondro- and fibrocytes and the synovia showed positive staining for almost all IGFs and IGFBPs. The underlying tissue, consisting of connective tissue or chondroid matrix, was stained as well but more weakly so. We conclude that the IGF/IGFBP system seems to contribute to the pathogenesis of SC, especially IGF-I and -II, and their effects enhancing binding protein 5.
authors.affiliation: Department of Oral and Maxillofacial and Plastic Surgery (Head: Prof. Dr. Dr. R.H. Reich), University of Bonn, Welschnonnenstraße 17, 53111 Bonn, Germany. Electronic address: christian.wilms@ukb.uni-bonn.de.
authors.forename: Christian T
authors.initials: CT
authors.lastname: Wilms
authors.affiliation: Department of Oral and Maxillofacial and Plastic Surgery (Head: Prof. Dr. Dr. R.H. Reich), University of Bonn, Welschnonnenstraße 17, 53111 Bonn, Germany.
authors.forename: Nils
authors.initials: N
authors.lastname: Heim
authors.affiliation: Department of Oral and Maxillofacial and Plastic Surgery (Head: Prof. Dr. Dr. R.H. Reich), University of Bonn, Welschnonnenstraße 17, 53111 Bonn, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Teschke
authors.affiliation: Department of Oral and Maxillofacial and Plastic Surgery (Head: Prof. Dr. Dr. R.H. Reich), University of Bonn, Welschnonnenstraße 17, 53111 Bonn, Germany.
authors.forename: Rudolf R
authors.initials: RR
authors.lastname: Reich
authors.affiliation: Department of Oral and Maxillofacial and Plastic Surgery (Head: Prof. Dr. Dr. R.H. Reich), University of Bonn, Welschnonnenstraße 17, 53111 Bonn, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Götz
mesh_terms: D000328:Adult; D000368:Aged; D019902:Chondrocytes / Q000378:metabolism / Q000473:pathology; D015838:Chondromatosis, Synovial / Q000209:etiology* / Q000473:pathology; D004396:Coloring Agents; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism* / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000378:metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013002:Somatomedins / Q000378:metabolism* / Q000502:physiology; D013582:Synovial Fluid / Q000378:metabolism; D013705:Temporomandibular Joint Disorders / Q000209:etiology* / Q000473:pathology
chemical_list: D004396:Coloring Agents; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II
keywords: Insulin-like growth factor (IGF); Insulin-like growth factor binding protein (IGFBP); Synovial chondromatosis; Temporomandibular joint