title: Targeting sonic hedgehog signaling in neurological disorders.
abstract: Sonic hedgehog (Shh) signaling influences neurogenesis and neural patterning during the development of central nervous system. Dysregulation of Shh signaling in brain leads to neurological disorders like autism spectrum disorder, depression, dementia, stroke, Parkinson's diseases, Huntington's disease, locomotor deficit, epilepsy, demyelinating disease, neuropathies as well as brain tumors. The synthesis, processing and transport of Shh ligand as well as the localization of its receptors and signal transduction in the central nervous system has been carefully reviewed. Further, we summarize the regulation of small molecule modulators of Shh pathway with potential in neurological disorders. In conclusion, further studies are warranted to demonstrate the potential of positive and negative regulators of the Shh pathway in neurological disorders.
authors.affiliation: Department of Pharmacy, Jaypee University of Information Technology, Waknaghat 173234, Himachal Pradesh, India.
authors.forename: Sita Sharan
authors.initials: SS
authors.lastname: Patel
authors.affiliation: School of Pharmaceutical Sciences, Shoolini University, Post Box 9, Solan 173212, Himachal Pradesh, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Tomar
authors.affiliation: School of Pharmaceutical Sciences, Shoolini University, Post Box 9, Solan 173212, Himachal Pradesh, India.
authors.forename: Diksha
authors.initials: D
authors.lastname: Sharma
authors.affiliation: School of Pharmaceutical Sciences, Shoolini University, Post Box 9, Solan 173212, Himachal Pradesh, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mahindroo
authors.affiliation: Department of Pharmacy, Jaypee University of Information Technology, Waknaghat 173234, Himachal Pradesh, India. Electronic address: m_udayabanu@rediffmail.com.
authors.forename: Malairaman
authors.initials: M
authors.lastname: Udayabanu
mesh_terms: D000067877:Autism Spectrum Disorder; D053823:Hedgehog Proteins; D006801:Humans; D009422:Nervous System Diseases; D055495:Neurogenesis; D015398:Signal Transduction
chemical_list: D053823:Hedgehog Proteins
keywords: Neurogenesis; Neurological disorders; Small molecules; Sonic hedgehog