title: Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform.
abstract: Advancements in medical device and imaging technology as well as accruing clinical evidence have accelerated the growth of the endovascular treatment of cerebrovascular diseases. However, the augmented role of these procedures raises concerns about the radiation dose to patients and operators. We evaluated patient doses from an x-ray imaging platform with radiation dose-reduction technology, which combined image noise reduction, motion correction, and contrast-dependent temporal averaging with optimized x-ray exposure settings.
  
  
  
  In this single-center, retrospective study, cumulative dose-area product inclusive of fluoroscopy, angiography, and 3D acquisitions for all neurovascular procedures performed during a 2-year period on the dose-reduction platform were compared with a reference platform. Key study features were the following: The neurointerventional radiologist could select the targeted dose reduction for each patient with the dose-reduction platform, and the statistical analyses included patient characteristics and the neurointerventional radiologist as covariates. The analyzed outcome measures were cumulative dose (kerma)-area product, fluoroscopy duration, and administered contrast volume.
  
  
  
  A total of 1238 neurointerventional cases were included, of which 914 and 324 were performed on the reference and dose-reduction platforms, respectively. Over all diagnostic and neurointerventional procedures, the cumulative dose-area product was significantly reduced by 53.2% (mean reduction, 160.3 Gy × cm2;P< .0001), fluoroscopy duration was marginally significantly increased (mean increase, 5.2 minutes;P= .0491), and contrast volume was nonsignificantly increased (mean increase, 15.3 mL;P= .1616) with the dose-reduction platform.
  
  
  
  A significant reduction in patient radiation dose is achievable during neurovascular procedures by using dose-reduction technology with a minimal impact on workflow.
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: K
authors.identifier: 0000-0003-1099-9498
authors.initials: K
authors.lastname: van der Marel
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: S
authors.identifier: 0000-0003-4123-8392
authors.initials: S
authors.lastname: Vedantham
authors.affiliation: Philips Healthcare (I.M.J.v.d.B.), Best, the Netherlands.
authors.forename: I M J
authors.identifier: 0000-0002-3576-3062
authors.initials: IM
authors.lastname: van der Bom
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: M
authors.identifier: 0000-0003-0390-4251
authors.initials: M
authors.lastname: Howk
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: T
authors.identifier: 0000-0003-2328-9639
authors.initials: T
authors.lastname: Narain
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: K
authors.identifier: 0000-0001-5753-6744
authors.initials: K
authors.lastname: Ty
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: A
authors.identifier: 0000-0002-5877-3677
authors.initials: A
authors.lastname: Karellas
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts Matthew.Gounis@umassmed.edu.
authors.forename: M J
authors.identifier: 0000-0002-8034-2785
authors.initials: MJ
authors.lastname: Gounis
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: A S
authors.identifier: 0000-0002-6978-6457
authors.initials: AS
authors.lastname: Puri
authors.affiliation: From the Department of Radiology (K.v.d.M., S.V., M.H., T.N., K.T., A.K., M.J.G., A.S.P., A.K.W.), New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.
authors.forename: A K
authors.identifier: 0000-0003-2126-4155
authors.initials: AK
authors.lastname: Wakhloo
mesh_terms: D000368:Aged; D015901:Angiography, Digital Subtraction / Q000379:methods*; D002533:Cerebral Angiography / Q000379:methods*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000601:surgery*; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D000069079:Radiation Exposure; D015641:Radiography, Interventional / Q000379:methods*; D012189:Retrospective Studies; D014965:X-Rays