title: Expeditious assembly of fused dihydropyranones via N-heterocyclic carbene-catalyzed tandem Michael addition/lactonization.
abstract: A convergent and efficient NHC-catalyzed enantioselective tandem Michael addition/lactonization sequence of ynals with 1,2-dione as the dual-nucleophile is disclosed. This straightforward strategy expeditiously assembles the synthetically and pharmaceutically valuable optically active fused dihydropyranones in good to high yields (70-88%) and with excellent enantioselectivities (92-99% ee).
authors.affiliation: College of Pharmaceutical Science, Southwest University, Chongqing 400715, P. R. China. qren2014@swu.edu.cn yuanlujiang@hotmail.com.
authors.forename: Qiao
authors.identifier: http://orcid.org/0000-0002-1933-0160
authors.initials: Q
authors.lastname: Ren
authors.affiliation: College of Pharmaceutical Science, Southwest University, Chongqing 400715, P. R. China. qren2014@swu.edu.cn yuanlujiang@hotmail.com.
authors.forename: Muyao
authors.initials: M
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Science, Southwest University, Chongqing 400715, P. R. China. qren2014@swu.edu.cn yuanlujiang@hotmail.com.
authors.forename: Lujiang
authors.initials: L
authors.lastname: Yuan