title: UVA-1 exposure in vivo leads to an IL-6 surge within the skin.
abstract: UVA-1 is a known promotor of skin ageing. Cytokines like IL-1α, Il-1β or TNF-α, VEGF and IL-6 orchestrate UV effects, and IL-6 is furthermore an effector of UVA-induced photoageing. We investigated how fractionated UVA-1 doses influence the cytokine milieu and especially the IL-6 levels in the skin in vivo. In a study with 35 participants, we exposed previously unirradiated human skin to three UVA-1 irradiation regimes. Cytokine levels in interstitial skin fluid were measured up to 48 hours postexposure and compared to unirradiated control skin fluid. Our results show that IL-6 levels increased significantly after UVA-1 exposure at selected time points. The other candidates IL-1α, Il-1β or TNF-α and VEGF show no significant response after UVA-1 exposure in vivo. UVA-1 thus raises selectively IL-6 levels in vivo, a fact that underlines its role in photoageing and has potential implications for its modulatory effect on photoageing pathology.
authors.affiliation: University Department of Dermatology and Allergology, Ulm, Germany.|Department of Dermatology and Allergology, Helios Klinik Rottweil, Rottweil, Germany.
authors.forename: Lars Alexander
authors.initials: LA
authors.lastname: Schneider
authors.affiliation: University Department of Dermatology and Allergology, Ulm, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Raizner
authors.affiliation: University Department of Dermatology and Allergology, Ulm, Germany.
authors.forename: Meinhard
authors.initials: M
authors.lastname: Wlaschek
authors.affiliation: Heinrich-Heine-University Medical Faculty Biochemistry & Molecular Biology I, Duesseldorf, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Brenneisen
authors.affiliation: University Department of Dermatology and Allergology, Ulm, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Gethöffer
authors.affiliation: University Department of Dermatology and Allergology, Ulm, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Scharffetter-Kochanek
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D015595:Skin Aging; D014466:Ultraviolet Rays; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: IL-6; UVA radiation; UVA-1; inflammation; skin; suction blister