title: Collapse of human scalp microbiome network in dandruff and seborrhoeic dermatitis.
abstract: We investigate the relationship between scalp microbiota and dandruff/seborrhoeic dermatitis (D/SD), an unpleasant scalp disorder common in human populations. Bacterial and fungal community analyses on scalp of 102 Korean were performed by next-generation sequencing. Overall scalp microbiome composition significantly differed between normal and disease groups, and especially co-occurrence network of dominant members was breakdown in disease groups. These findings will provide novel insights into shifts of microbial community relevant to D/SD.
authors.affiliation: Skin Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea.
authors.forename: Taehun
authors.initials: T
authors.lastname: Park
authors.affiliation: Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
authors.forename: Nu Ri
authors.initials: NR
authors.lastname: Myeong
authors.affiliation: Skin Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea.
authors.forename: Hyun Gee
authors.initials: HG
authors.lastname: Lee
authors.affiliation: Skin Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea.
authors.forename: Ilyoung
authors.initials: I
authors.lastname: Kwack
authors.affiliation: Skin Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea.
authors.forename: Johnhwan
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
authors.forename: Woo Jun
authors.initials: WJ
authors.lastname: Sul
authors.affiliation: Skin Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea.
authors.forename: Susun
authors.initials: S
authors.lastname: An
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D063807:Dandruff / Q000382:microbiology*; D012628:Dermatitis, Seborrheic / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D064307:Microbiota; D008875:Middle Aged; D012535:Scalp / Q000382:microbiology*
keywords: dandruff; next generation sequencing; scalp microbiome; seborrheic dermatitis