title: Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study.
abstract: We investigated the association between age of onset of hypertension and dementia risk in an oldest-old cohort.
  
  
  
  Participants are from The 90+ Study, a population-based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self-reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years.
  
  
  
  A total of 224 participants developed dementia during follow-up (mean = 2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80 to 89 years had a lower dementia risk (hazard ratio = 0.58, P = .04) and participants with an onset age of 90+ years had the lowest risk (hazard ratio = 0.37, P = .004).
  
  
  
  Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly.
authors.affiliation: Department of Neurology, University of California Irvine, Irvine, CA, USA; Department of Epidemiology, University of California Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA. Electronic address: mcorrada@uci.edu.
authors.forename: María M
authors.initials: MM
authors.lastname: Corrada
authors.affiliation: Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Hayden
authors.affiliation: Department of Neurology, University of California Irvine, Irvine, CA, USA.
authors.forename: Annlia
authors.initials: A
authors.lastname: Paganini-Hill
authors.affiliation: Department of Neurology, University of California Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
authors.forename: Szofia S
authors.initials: SS
authors.lastname: Bullain
authors.affiliation: Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
authors.forename: Jaime
authors.initials: J
authors.lastname: DeMoss
authors.affiliation: Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
authors.forename: Colette
authors.initials: C
authors.lastname: Aguirre
authors.affiliation: Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Ron
authors.initials: R
authors.lastname: Brookmeyer
authors.affiliation: Department of Neurology, University of California Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
authors.forename: Claudia H
authors.initials: CH
authors.lastname: Kawas
mesh_terms: D017668:Age of Onset; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003704:Dementia / Q000150:complications / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D000073216:Mental Status and Dementia Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D057566:Self Report; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D000959:Antihypertensive Agents
keywords: Blood pressure; Dementia; Epidemiology; Hypertension; Oldest-old; Risk factors