title: Acute localized exanthematous pustulosis caused by cefoperazone and sodium sulbactam.
abstract: Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings showed subcorneal pustules and mixed inflammatory cell infiltration in the dermis. The pustules resolved within about two weeks after the patient discontinued the antibiotics. This report discusses the case of a woman with a cutaneous drug reaction consistent with acute localized exanthematous pustulosis that occurred after cefoperazone and sodium sulbactam were administered.
authors.affiliation: The 251st Hospital of Chinese PLA - Zhangjiakou city, China.
authors.forename: Yan-Jing
authors.initials: YJ
authors.lastname: Qu
authors.affiliation: HanDan Central Hospital - Handan city, China.
authors.forename: Shu-Bin
authors.initials: SB
authors.lastname: Jin
authors.affiliation: The First Affiliated Hospital to Hebei North University - Zhangjiakou city, China.
authors.forename: Xiang-Chun
authors.initials: XC
authors.lastname: Han
authors.affiliation: The 251st Hospital of Chinese PLA - Zhangjiakou city, China.|Chinese People's Liberation Army General Hospital - Beijing, China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Zheng
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000209:etiology* / Q000473:pathology*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001706:Biopsy; D002438:Cefoperazone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology; D013407:Sulbactam / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D002438:Cefoperazone; D013407:Sulbactam