title: Incidence and risk factors of recurrence of overactive bladder symptoms after discontinuation of successful medical treatment.
abstract: To identify incidence and risk factors of recurrence after discontinuation of successful antimuscarinic therapy in patients with overactive bladder (OAB).
  
  
  
  This was a prospective, multicenter trial. Patients who had antimuscarinic agents for more than 12 weeks and showed successful response were enrolled. Successful response was defined as answering 'benefit' for patient perception of treatment benefit and answer lesser than 3 points in patient's perception of bladder condition (PPBC). The enrolled patients discontinued the antimuscarinics, and we evaluated their recurrence with PPBC and OAB symptom score (OABSS) at 1, 3, 6, and 12 months. Primary purpose was to identify the recurrence rate and secondary purpose was to reveal risk factors.
  
  
  
  Four hundred forty-one patients enrolled and 371 patients completed 6-month follow-up. The enrolled patients showed 1.6 points in PPBC, 2.9 points in OABSS and 1.4 points in IPSS (quality of life) which represented successful response after using antimuscarinics. The cumulative rates of recurrence were 25.6%, 42.3%, and 52.2% at 1, 3, 6 months, respectively. Among 177 patients who did not show recurrence at 6 months, 41 patients were followed up and 4 patients of the 41 patients (9.7%) showed recurrence at 12 months. On univariate and multivariate analyses of recurrence, OAB wet was the risk factor for recurrence after 6 months of discontinuation.
  
  
  
  Discontinuation of antimuscarinic therapy after successful treatment resulted in high recurrence rate with time and OAB wet was the independent risk factor for recurrence.
authors.affiliation: Department of Urology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
authors.forename: Aram
authors.initials: A
authors.lastname: Kim
authors.affiliation: Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kyu-Sung
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Urology, Gil Medicine Center, Gachon University of Medicine and Science, Incheon, Korea.
authors.forename: Tae Beom
authors.initials: TB
authors.lastname: Kim
authors.affiliation: Department of Urology, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Urology, Kyungpook National University, Daegu, Korea.
authors.forename: Eun Sang
authors.initials: ES
authors.lastname: Yoo
authors.affiliation: Department of Urology, Soonchunhyang University Gumi Hospital, Soonchunhyang University School of Medicine, Gumi, Korea.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Yun
authors.affiliation: Department of Urology, Catholic University of Daegu School of Medicine, Daegu, Korea.
authors.forename: Duk Yoon
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Department of Urology, Daedong Hospital, Busan, Korea.
authors.forename: Suk Gun
authors.initials: SG
authors.lastname: Jung
authors.affiliation: Department of Urology, Busan Saint Mary's Medical Center, Busan, Korea.
authors.forename: Jun Taik
authors.initials: JT
authors.lastname: Lee
authors.affiliation: Department of Urology, Busan Saint Mary's Medical Center, Busan, Korea.
authors.forename: Jung Man
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Urology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Cheol Kyu
authors.initials: CK
authors.lastname: Oh
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Shin
authors.affiliation: Department of Urology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Jeon
authors.affiliation: Department of Urology, Hallym University Dongtan Sacred Heart Hospital, Hallym University School of Medicine, Hwaseong, Korea.
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Urology, The Catholic University College of Medicine, Seoul, Korea.
authors.forename: Chang Hee
authors.initials: CH
authors.lastname: Han
authors.affiliation: Department of Urology, Incheon St. Mary's Hospital, The Catholic University College of Medicine, Incheon, Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Urology, Seoul St. Mary's Hospital, The Catholic University College of Medicine, Seoul, Korea.
authors.forename: Hyuk Jin
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Urology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
authors.forename: Myung-Soo
authors.initials: MS
authors.lastname: Choo
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D011446:Prospective Studies; D011788:Quality of Life; D012008:Recurrence; D012307:Risk Factors; D063189:Symptom Assessment; D053201:Urinary Bladder, Overactive / Q000150:complications / Q000188:drug therapy*; D028761:Withholding Treatment
chemical_list: D018727:Muscarinic Antagonists
keywords: Antimuscarinic treatment; Overactive bladder; Recurrence