title: Varied presentations of leptospirosis: experience from a tertiary care hospital in north India.
abstract: Leptospirosis has been recognised as an emerging global public health problem. The aim of our study was to explore the epidemiological and clinical pattern of disease occurrence in suspected cases and to search for any existing co-infections. Ours was a retrospective study in patients with acute febrile illness in north India over a period of three years (April 2011 to June 2014). Serological diagnosis of leptospirosis was made using the PanBio IgM ELISA kit. Using modified Faine's criteria, presumptive and possible diagnosis was made in 57% and 34% cases, respectively. Most of the affected population was resident in north and central India. Nineteen patients showed co-infection with other common pathogens prevailing locally. There is a need to increase awareness and understand the local sero-epidemiological pattern of leptospirosis so that timely preventive and curative action may be taken by healthcare authorities.
authors.affiliation: 1 Professor, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Rama
authors.initials: R
authors.lastname: Chaudhry
authors.affiliation: 2 Ex Senior Resident, Department of Microbiology All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Karnika
authors.initials: K
authors.lastname: Saigal
authors.affiliation: 3 PhD Scholar, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Tej
authors.initials: T
authors.lastname: Bahadur
authors.affiliation: 4 Senior Resident, Department of Microbiology All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Kamla
authors.initials: K
authors.lastname: Kant
authors.affiliation: 3 PhD Scholar, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Bishwanath
authors.initials: B
authors.lastname: Chourasia
authors.affiliation: 5 Senior Resident, Infectious Disease Division, Department of Medicine and Microbiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Nitin
authors.initials: N
authors.lastname: Gupta
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D060085:Coinfection / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005334:Fever / Q000382:microbiology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D007194:India / Q000453:epidemiology; D007922:Leptospirosis / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007075:Immunoglobulin M
keywords: Varied presentation; co-infections; complications; leptospirosis; north India