title: Association between herpes simplex virus Types 1 and 2 with cardiac myxoma.
abstract: Most cases of atrial myxoma are sporadic, and the exact etiology is unknown. We examined if herpes simplex virus (HSV)-1 and HSV-2 antigens and/or DNA could be detected in a cohort of Iranian patients with cardiac myxomas. From July 2004 to June 2014, among a total of 36,703 patients undergoing open heart surgeries, consecutive patients with cardiac myxoma who were treated by surgical excision at our center included in this study. Of 73 patients studied, 56% were female with a mean age of 54 years (ranging from 23 to 77 years). Seventy-four myxomas were surgically removed from 73 patients, since one patient had two myxomas which were located on both the right atrium and right ventricle. The materials for this analysis were retrospectively gathered from extracted tumors that stored in a pathology bank of tissue paraffin blocks. The formalin fixed paraffin embedded tissue samples were investigated for HSV genomic DNA by both immunohistochemistry (IHC) and polymerase chain reaction (PCR) analysis. In all 74 cases there was no presence of HSV 1 and HSV 2 infection. This suggests that HSV may not play a role in sporadic cardiac myxomas; however, evidence for such association is currently lacking, and further studies are required to determine such a role.
authors.affiliation: Department of pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.. Electronic address: maryamsotoudeh2006@yahoo.com.
authors.forename: Maryam Sotoudeh
authors.initials: MS
authors.lastname: Anvari
authors.affiliation: Department of pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Moud
authors.initials: M
authors.lastname: Sabagh
authors.affiliation: Department of Clinical and Experimental Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Goodarzynejad
authors.affiliation: Department of pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shayan
authors.initials: S
authors.lastname: Ziaei
authors.affiliation: Department of pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Boroumand
authors.affiliation: Department of pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Leyla
authors.initials: L
authors.lastname: Pourgholi
authors.affiliation: Department of cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Yaser
authors.initials: Y
authors.lastname: Jenab
authors.affiliation: Department of cardiac surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Kyomars
authors.initials: K
authors.lastname: Abbasi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006338:Heart Neoplasms / Q000821:virology*; D006566:Herpesviridae Infections / Q000453:epidemiology*; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D006801:Humans; D007150:Immunohistochemistry; D007492:Iran; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000821:virology*; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
keywords: Cardiac myxoma; Herpes simplex virus; Immunohistochemistry