title: [Nicolau syndrome induced by intramuscular injection of a hexavalent vaccine in a 6-month-old girl].
abstract: Nicolau syndrome, also known as embolia cutis medicamentosa or livedo-like dermatitis, is a sudden tissue necrosis, a rare complication of intramuscular injection of some drugs. We report a case of a 6-month-old girl who received intramuscularly the third dose of hexavalent vaccine (DTaP- HVB-IPV/HIb), and immediately presented a livedoid lesion around the injection site, progressing to necrosis. We reinforce the importance of early diagnosis to perform a suitable treatment and clinical follow-up to avoid ischemic secondary complications.
authors.affiliation: Servicio de Dermatología, Hospital Nacional de Pediatría Prof. Dr. J. P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina. paoladermatologia@yahoo.com.ar.
authors.forename: Paola C
authors.initials: PC
authors.lastname: Stefano
authors.affiliation: Consultorios Externos, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Mónica
authors.initials: M
authors.lastname: Garello
authors.affiliation: División de Promoción y Protección para la Salud, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: María F
authors.initials: MF
authors.lastname: Nolte
authors.affiliation: División de Promoción y Protección para la Salud, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Patricia
authors.initials: P
authors.lastname: Lamy
authors.affiliation: División de Promoción y Protección para la Salud, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Norberto
authors.initials: N
authors.lastname: Giglio
authors.affiliation: División de Promoción y Protección para la Salud, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Castellano
authors.affiliation: División de Promoción y Protección para la Salud, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Gentile
mesh_terms: D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular / Q000009:adverse effects; D065148:Nicolau Syndrome / Q000209:etiology*; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage; D017778:Vaccines, Combined / Q000008:administration & dosage
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D017325:Hepatitis B Vaccines; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined; C541235:diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine
keywords: Nicolau syndrome; embolia cutis medicamentosa; hexavalent vaccine; livedolike dermatitis