title: Serum obestatin and omentin levels in patients with diabetic nephropathy.
abstract: BACKGROUND
  Diabetic nephropathy is the leading cause of chronic kidney disease and accounts for almost 45% of all new patients requiring renal replacement therapy. Omentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors. Thus, we postulated that they may also have an association with diabetic nephropathy which is known to be an independent cardiovascular risk factor. In order to investigate such an association we compared serum omentin and obestatin levels in type 2 diabetic patients with normoalbuminuria (NA) and macroalbuminuria (MA).
  
  
  METHODS
  A total of 81 type 2 diabetic patients were separated into two groups according to their proteinuria status; patients with NA (n = 39) and patients with MA (n = 42). Two groups were compared in terms of serum omentin and obestatin levels.
  
  
  RESULTS
  While s erum omentin levels did not differ among two groups (P = 0.407), serum obestatin levels were significantly higher in MA group (P = 0.001).
  
  
  CONCLUSIONS
  The results of this study showed that higher serum levels of obestatin were associated with macro albuminuria suggesting that obestatin may have a role in underlying pathogenic mechanisms that leads to diabetic nephropathy.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Zorlu
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kiskac
authors.affiliation: Deparment of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey.
authors.forename: E M
authors.initials: EM
authors.lastname: Güler
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Gültepe
authors.affiliation: Department of Family Medicine, Samsun Teaching and Research Hospital, 55100 Samsun, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Yavuz
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Çelik
authors.affiliation: Deparment of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kocyigit
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000652:urine; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000652:urine; D003928:Diabetic Nephropathies / Q000097:blood* / Q000209:etiology; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011507:Proteinuria / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000150:complications; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; D054439:Ghrelin; C432397:ITLN1 protein, human; D037102:Lectins