title: Advance of autophagy in chronic kidney diseases.
abstract: Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues and experimental animal models implicate that autophagy regulation is the critical aspects in chronic kidney diseases (CKD). Here, we summarize the current studies on the role of autophagy in CKD. Unveiling the precise regulation mechanism of autophagy in CKD is essential for developing potential prevention, diagnostic and therapeutic targets of these sticky clinical challenges.
authors.affiliation: a Department of Nephrology , Children's Hospital of Nanjing Medical University , Nanjing , China.|b Jiangsu Key Laboratory of Pediatrics , Nanjing Medical University , Nanjing , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Deng
authors.affiliation: a Department of Nephrology , Children's Hospital of Nanjing Medical University , Nanjing , China.|b Jiangsu Key Laboratory of Pediatrics , Nanjing Medical University , Nanjing , China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Xie
authors.affiliation: a Department of Nephrology , Children's Hospital of Nanjing Medical University , Nanjing , China.|b Jiangsu Key Laboratory of Pediatrics , Nanjing Medical University , Nanjing , China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhang
mesh_terms: D001343:Autophagy; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction
keywords: Autophagy; chaperone-mediated autophagy; chronic kidney diseases; macroautophagy; microautophagy