title: Amhezole, A Novel Fungal Secondary Metabolite from Aspergillus terreus for Treatment of Microbial Mouth Infection.
abstract: Bio-guided fractionation of Aspergillus terreus extract leads to isolation of a novel terpenoidal secondary metabolite. The isolated compound and the total alcoholic extract of Aspergillus terreus showed a remarkable activity against microbial mouth infections; namely, Candida albicans, Lactobacillus acidophilus, Streptococcus gordonii, and S. mutan. Moreover, the Minimum Inhibitory Concentration of the isolated compound was determined and showed low values. The combination of each of the alcoholic extract of A. terreus and the isolated compound Coe-Comfort tissue conditioner inhibited the growth of Candida albicans at concentrations of 500 and 7.81 µg/mL, respectively, Lactobacillus acidophilus at concentrations of 250 and 7.81 µg/mL, respectively, Streptococcus gordonii at concentrations of 1000 and 62.50 µg/mL, respectively, and S. mutans at concentrations of 1000 and 125 µg/mL, respectively. The oral dosing of the extract and the isolated compound did not show any significant effect on the activity of alanine aminotransferase, aspirate aminotransferase, and the levels of blood urea and serum creatinine. Copyright © 2017 John Wiley & Sons, Ltd.
authors.affiliation: Pharmacognosy Department, College of Pharmacy, Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
authors.forename: Amani S
authors.identifier: http://orcid.org/0000-0001-7910-6841
authors.initials: AS
authors.lastname: Awaad
authors.affiliation: Microbiology Department, Faculty of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Hind A
authors.initials: HA
authors.lastname: Al-Mudhayyif
authors.affiliation: Microbiology Department, Faculty of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Monerah R
authors.initials: MR
authors.lastname: Al-Othman
authors.affiliation: Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Zain
authors.affiliation: Aromatic and Medicinal Plants Department, Desert Research Center, Cairo, Egypt.
authors.forename: Reham M
authors.initials: RM
authors.lastname: El-Meligy
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000627:therapeutic use* / Q000633:toxicity; D001230:Aspergillus / Q000737:chemistry* / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002911:Chrysenes / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D007239:Infections / Q000188:drug therapy*; D007779:Lactobacillus acidophilus / Q000187:drug effects / Q000254:growth & development; D008297:Male; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000187:drug effects / Q000382:microbiology; D009059:Mouth Diseases / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
chemical_list: D000890:Anti-Infective Agents; D002911:Chrysenes; C000618351:amhezole
keywords: Amhezole; Aspergillus terreus; Candida albicans; new structures; terpenes