title: Mannose receptor as a potential biomarker for gastric cancer: a pilot study.
abstract: BACKGROUND
  The mannose receptor is an immune adhesion molecule mainly expressed on the surface of antigen-presenting cells such as nonmature dendritic cells and macrophages. This study aimed to investigate mannose receptor expression and its predictive role in papillary gastric cancer patients.
  
  
  METHODS
  The expression of the mannose receptor was measured in 120 samples of gastric cancer tissues and corresponding paracarcinoma tissues, by immunohistochemical and quantitative real-time PCR analysis. The relationships between mannose receptor expression and clinicopathological features of gastric cancer patients were analyzed.
  
  
  RESULTS
  The expression rate of the mannose receptor in gastric cancer cells was 45.8% (54/120), significantly higher than that in the paracarcinoma tissue (20.0%, 36/120) (χ2 = 6.286, p = 0.012). High expression of the mannose receptor was closely related to tumor size, T stage, N stage and Union for International Cancer Control (UICC) stage of gastric cancer (p<0.05). A Kaplan-Meier survival model indicated that the survival of patients in the high-expression mannose receptor group was significantly shorter than in the low-expression mannose receptor group (p<0.05). Cox regression analysis showed that high mannose receptor expression was an independent predictor for the prognosis of patients with gastric cancer.
  
  
  CONCLUSIONS
  High mannose receptor expression indicates poor prognosis for gastric cancer patients. The mannose receptor may be an important molecular marker for gastric cancer prognosis.
authors.affiliation: Department of Surgery, First Hospital of Lanzhou University, Lanzhou, Gansu Province - PR China.
authors.forename: Deng-Rui
authors.initials: DR
authors.lastname: Liu
authors.affiliation: Department of Surgery, First Hospital of Lanzhou University, Lanzhou, Gansu Province - PR China.
authors.forename: Quan-Lin
authors.initials: QL
authors.lastname: Guan
authors.affiliation: Department of Surgery, First Hospital of Lanzhou University, Lanzhou, Gansu Province - PR China.
authors.forename: Ming-Tai
authors.initials: MT
authors.lastname: Gao
authors.affiliation: Department of Surgery, First Hospital of Lanzhou University, Lanzhou, Gansu Province - PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Surgery, First Hospital of Lanzhou University, Lanzhou, Gansu Province - PR China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D008297:Male; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface