title: Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis.
abstract: Although the association between CAG and GGN repeats in the androgen receptor gene and prostate cancer risk has been widely studied, it remains controversial from previous meta-analyses and narrative reviews. Therefore, we performed this meta-analysis to provide more precise estimates with sufficient power. A total of 51 publications with 61 studies for CAG repeats and 14 publications with 16 studies for GGN repeats were identified in the meta-analysis. The results showed that short CAG repeats (<22 repeats) carriers presented an elevated risk of prostate cancer than long CAG repeats (≥22) carriers (OR = 1.31, 95% CI 1.16 to 1.47). Prostate cancer cases presented an average fewer CAG repeats (MD = -0.85, 95% CI -1.28 to -0.42) than controls. Short GGN repeats (≤16) carriers presented an increased risk of prostate cancer than long GGN repeats (>16) carriers (OR = 1.38, 95% CI 1.05 to 1.82). In subgroup analyses, the abovementioned significant association was predominantly observed in Caucasian populations. The meta-analysis showed that short CAG and GGN repeats in androgen receptor gene were associated with increased risk of prostate cancer, especially in Caucasians.
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.|Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Weng
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.|Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.|Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Huang
authors.affiliation: Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, P.R. China.
authors.forename: Zi-Qi
authors.initials: ZQ
authors.lastname: He
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Meng
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Fang
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.|Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D017594:Publication Bias; D011944:Receptors, Androgen / Q000235:genetics*; D012307:Risk Factors; D018401:Sample Size; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: D011944:Receptors, Androgen