title: Chondroitin sulfates and their binding molecules in the central nervous system.
abstract: Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix. A better understanding of these interactions could promote a development of inhibitors to treat neurodegenerative diseases.
authors.affiliation: Institut de Biologie Structurale, University Grenoble Alpes, CNRS, CEA, F-38027, Grenoble, France.
authors.forename: L
authors.initials: L
authors.lastname: Djerbal
authors.affiliation: Institut de Biologie Structurale, University Grenoble Alpes, CNRS, CEA, F-38027, Grenoble, France. hugues.lortat-jacob@ibs.fr.
authors.forename: H
authors.initials: H
authors.lastname: Lortat-Jacob
authors.affiliation: School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. j.kwok@leeds.ac.uk.
authors.forename: Jcf
authors.initials: J
authors.lastname: Kwok
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D002490:Central Nervous System / Q000737:chemistry* / Q000378:metabolism; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000378:metabolism; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry* / Q000378:metabolism; D000078792:Midkine; D019006:Neural Cell Adhesion Molecules / Q000737:chemistry* / Q000378:metabolism; D009474:Neurons / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism; D054557:Receptor-Like Protein Tyrosine Phosphatases / Q000737:chemistry / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D019006:Neural Cell Adhesion Molecules; D011509:Proteoglycans; C066845:pleiotrophin; D000078792:Midkine; D002809:Chondroitin Sulfates; D054557:Receptor-Like Protein Tyrosine Phosphatases
keywords: Central nervous system; Chondroitin sulfate; Glycosaminoglycans; Perineuronal nets; Plasticity; Protein-glycosaminoglycan interactions; Proteoglycans