title: Comparative Analysis on the Effect of Plantago Species Aqueous Extracts on Tissue Trace Element Content in Rats.
abstract: The primary objective of this study is to assess the influence of water extracts of Plantago major L., Plantago lanceolata L., and Plantago maxima Juss. ex Jacq. leaves on tissue trace element content in healthy adult Wistar rats. Twenty-eight female Wistar rats consumed pure drinking water or one of the three aqueous extracts of Plantago for 1 month. The extracts and liver, serum, hair, and adipose tissue of the rats were examined for trace element contents using inductively coupled plasma mass spectrometry. The aqueous extracts of Plantago species contained significant levels of trace elements, which were highest in P. lanceolata and P. major. The administration of every extract led to an increase in V and Si levels in the rats. At the same time, the consumption of P. lanceolata aqueous extract resulted in the accumulation of toxic elements (As, Pb) in the rats' tissues. Despite the rather high concentration of heavy metals in the P. major leaf extract, its administration did not result in the accumulation of these elements. In turn, P. maxima extract induced a significant decrease in the tissue levels of Al, Cr, I, Li, and Mn in the rats. The beneficial effect of the P. major and P. maxima preparations may be at least partially associated with the increased supply of essential trace elements, whereas the use of P. lanceolata may be harmful due to the possibility of heavy metal overexposure.
authors.affiliation: Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia.|South Ural State Medical University, Vorovskogo St., 64, Chelyabinsk, 454048, Russia.
authors.forename: Evgenia R
authors.initials: ER
authors.lastname: Gatiatulina
authors.affiliation: Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia.
authors.forename: Olga N
authors.initials: ON
authors.lastname: Nemereshina
authors.affiliation: Poznan University of Life Sciences, Wojska Polskiego St.28, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Suliburska
authors.affiliation: School of Energy and Environment, Thapar University, Patiala, 147004, India.
authors.forename: Tejo Prakash
authors.initials: TP
authors.lastname: Nagaraja
authors.affiliation: Lomonosov Moscow State University, Lomonosovsky Prospekt, 31-5, Moscow, 117192, Russia.
authors.forename: Anastasia A
authors.initials: AA
authors.lastname: Skalnaya
authors.affiliation: Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia.|Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia.
authors.forename: Alexandr A
authors.initials: AA
authors.lastname: Nikonorov
authors.affiliation: Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia.|RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia.|Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russia.|All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, 117216, Russia.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Skalny
authors.affiliation: Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia. tinkov.a.a@gmail.com.|Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia. tinkov.a.a@gmail.com.|RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia. tinkov.a.a@gmail.com.|Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russia. tinkov.a.a@gmail.com.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Tinkov
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000187:drug effects*; D000818:Animals; D005260:Female; D008099:Liver / Q000737:chemistry / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010943:Plantago / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014131:Trace Elements / Q000032:analysis*; D014867:Water / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D014131:Trace Elements; D014867:Water
keywords: Adipose tissue; Metals; Plantago; Silicon; Vanadium