title: Idiopathic gingival papillokeratosis with crypt formation, a report of 7 cases of a previously undescribed entity: possible unusual oral epithelial nevus?
abstract: We report 7 cases of hitherto undescribed keratotic papillary plaques of uncertain etiology involving the gingiva. All 7 cases presented on the anterior maxillary attached gingiva of patients in the second decade. The lesions were asymptomatic and 86% (6 of 7 cases) presented in a bilateral symmetric distribution. Microscopically, the lesions exhibited parakeratosis and papillary acanthosis with parakeratin-filled crypts. No specific etiology such as a factitial habit or a common exogenous agent has been identified. The possibility of a developmental etiology such as an oral epithelial nevus cannot be entirely excluded. We propose the descriptive term idiopathic gingival papillokeratosis with crypt formation (IGPC) for this condition.
authors.affiliation: Division of Oral Pathology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA; Center for Oral Pathology, StrataDx, Lexington, MA, USA. Electronic address: vnoonan@bu.edu.
authors.forename: Vikki L
authors.initials: VL
authors.lastname: Noonan
authors.affiliation: Center for Oral Pathology, StrataDx, Lexington, MA, USA; Department of Oral Medicine, Infection, and Immunity, Harvard University School of Dental Medicine, Boston, MA, USA.
authors.forename: Sook-Bin
authors.initials: SB
authors.lastname: Woo
authors.affiliation: Division of Oral Pathology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.
authors.forename: Devaki
authors.initials: D
authors.lastname: Sundararajan
authors.affiliation: Center for Oral Pathology, StrataDx, Lexington, MA, USA.
authors.forename: Sadru
authors.initials: S
authors.lastname: Kabani
authors.affiliation: Division of Oral Pathology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.
authors.forename: George
authors.initials: G
authors.lastname: Gallagher
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D005882:Gingival Diseases / Q000473:pathology*; D005887:Gingival Neoplasms / Q000473:pathology; D006801:Humans; D007642:Keratosis / Q000473:pathology*; D008297:Male; D008437:Maxilla / Q000473:pathology*; D009506:Nevus / Q000473:pathology; D055815:Young Adult