title: Metabolic Syndrome: One Speckled Stone Kills a Flock of Birds?
abstract: Effectively treating metabolic syndrome and its progression to type 2 diabetes, steatohepatitis and cardiovascular disease remain a major clinical challenge. The use of a novel engineered molecule that combines thyroid hormone and glucagon to target liver and adipose tissue might provide a new 'magic bullet' with exciting future prospects.
authors.affiliation: Metabolism Unit, Department of Endocrinology, Metabolism and Diabetes; Molecular Nutrition Unit, Center for Innovative Medicine; KI/AZ Integrated CardioMetabolic Center (ICMC), Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden.
authors.forename: Ylva
authors.initials: Y
authors.lastname: Bonde
authors.affiliation: Metabolism Unit, Department of Endocrinology, Metabolism and Diabetes; Molecular Nutrition Unit, Center for Innovative Medicine; KI/AZ Integrated CardioMetabolic Center (ICMC), Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden. Electronic address: bo.angelin@ki.se.
authors.forename: Bo
authors.initials: B
authors.lastname: Angelin
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control; D005234:Fatty Liver / Q000209:etiology / Q000517:prevention & control; D005934:Glucagon / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D006728:Hormones / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D014284:Triiodothyronine / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D006728:Hormones; D014284:Triiodothyronine; D005934:Glucagon