title: The cross-regulation between SOX15 and Wnt signaling pathway.
abstract: WNT/B-CATENIN signaling pathway is one of the key dysregulated pathways in different tumor types, which regulate the expression of several genes involved in cell proliferation, differentiation, and survival. This pathway is being modulated by sex-determining region Y-box (SOX) family genes. The functions of these genes are suggested as tumor suppressor or oncogene. SOX genes transcribe a group of transcription factors that play important roles in embryonic development and carcinogenesis. Among them, SOX15 is recently been identified as a novel tumor suppressor in pancreatic and esophagus cancers with a potential role in modulating Wnt/b-catenin signaling. This report summarizes the current knowledge about Wnt/b-catenin signaling pathway and its cross talk with SOX15 with particular emphasis on the value of SOX gene expression as prognostic or predictive biomarker in cancer.
authors.affiliation: Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Moradi
authors.affiliation: Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Ghasemi
authors.affiliation: Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kazem
authors.initials: K
authors.lastname: Anvari
authors.affiliation: Metabolic syndrome Research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Hassanian
authors.affiliation: Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Saeideh Ahmadi
authors.initials: SA
authors.lastname: Simab
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Safieh
authors.initials: S
authors.lastname: Ebrahimi
authors.affiliation: Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.|Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amirreza
authors.initials: A
authors.lastname: Hesari
authors.affiliation: Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Forghanifard
authors.affiliation: Department of Pharmacology and Pharmacological Research Center of Medicinal Plants, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Taher
authors.initials: MT
authors.lastname: Boroushaki
authors.affiliation: Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: ShahidSales
authors.affiliation: Metabolic syndrome Research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Avan
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D055747:SOX Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D060449:Wnt Signaling Pathway
chemical_list: D055747:SOX Transcription Factors
keywords: Sox15; WNT/B-CATENIN pathway; biomarker; cancer