title: Iron overload and altered iron metabolism in ovarian cancer.
abstract: Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients.
authors.affiliation: .
authors.forename: Stephanie
authors.initials: S
authors.lastname: Rockfield
authors.affiliation: .
authors.forename: Joseph
authors.initials: J
authors.lastname: Raffel
authors.affiliation: .
authors.forename: Radhe
authors.initials: R
authors.lastname: Mehta
authors.affiliation: .
authors.forename: Nabila
authors.initials: N
authors.lastname: Rehman
authors.affiliation: .
authors.forename: Meera
authors.initials: M
authors.lastname: Nanjundan
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000150:complications*; D010051:Ovarian Neoplasms / Q000150:complications* / Q000378:metabolism* / Q000382:microbiology; D018384:Oxidative Stress
chemical_list: D007501:Iron
keywords: endometriosis; fallopian tube fimbrial epithelium; microbiome; ovarian surface epithelium; therapy