title: Annual Incidence of Lassa Virus Infection in Southern Mali.
abstract: AbstractPreviously, we reported a high seroprevalence rate of Lassa virus antibodies in inhabitants of three villages in southern Mali where infected rodents have been demonstrated. Herein, we report a 1-year follow-up study in which we were able to collect a second blood samples from 88.7% of participants of the same cohort. We identified 23 seroconversions for IgG antibodies reactive against Lassa virus, representing an incidence of 6.3% (95% confidence interval = 3.8-8.8%). Seroconversion was frequently seen in preteenage children (12/23, 51.7%) and two household/familial clusters were identified. These results confirm active transmission of Lassa virus is occurring in southern Mali and appropriate diagnostic testing should be established for this etiological agent of severe viral hemorrhagic fever.
authors.affiliation: University of Manitoba, Winnipeg, Canada.|Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Safronetz
authors.affiliation: University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
authors.forename: Nafomon
authors.initials: N
authors.lastname: Sogoba
authors.affiliation: University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
authors.forename: Sory Ibrahim
authors.initials: SI
authors.lastname: Diawara
authors.affiliation: University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
authors.forename: Sidy
authors.initials: S
authors.lastname: Bane
authors.affiliation: Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
authors.forename: Kyle
authors.initials: K
authors.lastname: Rosenke
authors.affiliation: University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
authors.forename: Ousmane
authors.initials: O
authors.lastname: Maiga
authors.affiliation: Zalgen Labs, LLC, Germantown, Maryland.
authors.forename: Matt
authors.initials: M
authors.lastname: Boisen
authors.affiliation: Tulane School of Medicine, New Orleans, Louisiana.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Garry
authors.affiliation: Zalgen Labs, LLC, Germantown, Maryland.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Branco
authors.affiliation: University of Manitoba, Winnipeg, Canada.|Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Canada.
authors.forename: L Robbin
authors.initials: LR
authors.lastname: Lindsay
authors.affiliation: University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
authors.forename: Sékou F
authors.initials: SF
authors.lastname: Traoré
authors.affiliation: University of Manitoba, Winnipeg, Canada.|Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
authors.forename: Heinz
authors.initials: H
authors.lastname: Feldmann
authors.affiliation: University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
authors.forename: Seydou
authors.initials: S
authors.lastname: Doumbia
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007835:Lassa Fever / Q000453:epidemiology*; D008297:Male; D008302:Mali / Q000453:epidemiology; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D055815:Young Adult