title: Emerging technologies for long-term antimicrobial device coatings: advantages and limitations.
abstract: Over the past 20 years, the field of antimicrobial medical device coatings has expanded nearly 30-fold with technologies shifting their focus from diffusion-only based (short-term antimicrobial eluting) coatings to long-term antimicrobial eluting and intrinsically antimicrobial functioning materials. A variety of emergent coatings have been developed with the goal of achieving long-term antimicrobial activity in order to mitigate the risk of implanted device failure. Specifically, the coatings can be grouped into two categories: those that use antibiotics in conjunction with a polymer coating and those that rely on the intrinsic properties of the material to kill or repel bacteria that come into contact with the surface. This review covers both long-term drug-eluting and non-eluting coatings and evaluates the inherent advantages and disadvantages of each type while providing an overview of variety applications that the coatings have been utilized in. Impact statement This work provides an overview, with advantages and limitations of the most recently developed antibacterial coating technologies, enabling other researchers in the field to more easily determine which technology is most advantageous for them to further develop and pursue.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Erika L
authors.initials: EL
authors.lastname: Cyphert
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Horst A
authors.initials: HA
authors.lastname: von Recum
mesh_terms: D000890:Anti-Infective Agents; D057219:Biofouling / Q000517:prevention & control; D020811:Biomedical Technology / Q000379:methods / Q000639:trends*; D003300:Copper / Q000494:pharmacology; D053768:Metal Nanoparticles; D011108:Polymers; D019736:Prostheses and Implants / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D012834:Silver / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D011108:Polymers; D012834:Silver; D003300:Copper
keywords: Polymer; bacteria; biomedical; cardiovascular; chronic; drugs