title: Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer.
abstract: OBJECTIVE
  Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety.
  
  
  METHODS
  Thirty-one patients (age: 61 ± 12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min. Rectal temperature (Trec), systolic and diastolic blood pressures (SBP and DBP), pulse rate (PR), respiratory rate (RR), percutaneous oxygen saturation (SpO2) and sweating volume were evaluated throughout HT.
  
  
  RESULTS
  At 50 min after starting HT, Trec, PR and RR were significantly increased compared with the baseline values (Trec: 38.2 ± 1.4 vs. 36.3 ± 0.8 °C, p < 0.001, PR: 104 ± 15 vs. 85 ± 16 bpm, p < 0.05, RR: 23 ± 3 vs. 21 ± 3/min, p < 0.05). Although the average SBP and DBP were both stable during HT in a recumbent position, these values dropped significantly in a standing position (SBP: 113 ± 16 vs. 127 ± 18 mmHg, p < 0.001, DBP: 70 ± 12 vs. 75 ± 13 mmHg, p < 0.01). The total amount of sweating was 356 ± 173 g/m2on average.
  
  
  CONCLUSIONS
  Deep regional HT increased the deep body temperature and resulted in an increase of sweating with peripheral vasodilatation. Consequently, a significant reduction in BP would be induced on standing after HT. Careful attention is needed for patients receiving HT, especially when standing after HT.
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Rieko
authors.initials: R
authors.lastname: Izukura
authors.affiliation: b Cancer Treatment Center , Tobata Kyoritsu Hospital , Kitakyushu , Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Imada
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Hashiguchi
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sawatari
authors.affiliation: c Department of Radiology , University of Occupational and Environmental Health , Kitakyushu , Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohguri
authors.affiliation: d School of Nursing , Fukuoka Prefectural University , Fukuoka , Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Miyazono
authors.affiliation: b Cancer Treatment Center , Tobata Kyoritsu Hospital , Kitakyushu , Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Ohta
authors.affiliation: b Cancer Treatment Center , Tobata Kyoritsu Hospital , Kitakyushu , Japan.
authors.forename: Chiduko
authors.initials: C
authors.lastname: Takakura
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamasaki
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Magota
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Fujita
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kuroda
authors.affiliation: e Department of radiotherapy , St. Mary's Hospital , Kurume , Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Hirata
authors.affiliation: f Sleep Apnea Center, Kyushu University Hospital , Fukuoka , Japan.|g Faculty of Health Sciences , Ube Frontier University , Yamaguchi , Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ohkusa
authors.affiliation: a Department of Health Sciences , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Chishaki
keywords: BP decrease on standing; Cancer therapy; adjuvant therapy; deep regional hyperthermia; radiofrequency capacitive device