title: Vocal emotion decoding in the subthalamic nucleus: An intracranial ERP study in Parkinson's disease.
abstract: Using intracranial local field potential (LFP) recordings in patients with Parkinson's disease (PD) undergoing deep brain stimulation (DBS), we explored the electrophysiological activity of the subthalamic nucleus (STN) in response to emotional stimuli in the auditory modality. Previous studies focused on the influence of visual stimuli. To this end, we recorded LFPs within the STN in response to angry, happy, and neutral prosodies in 13 patients with PD who had just undergone implantation of DBS electrodes. We observed specific modulation of the right STN in response to anger and happiness, as opposed to neutral prosody, occurring at around 200-300ms post-onset, and later at around 850-950ms post-onset for anger and at around 3250-3350ms post-onset for happiness. Taken together with previous reports of modulated STN activity in response to emotional visual stimuli, the present results appear to confirm that the STN is involved in emotion processing irrespective of stimulus valence and sensory modality.
authors.affiliation: 'Neuroscience of Emotion and Affective Dynamics' Laboratory, Department of Psychology & Swiss Center for Affective Sciences, University of Geneva, 40 bd du Pont d'Arve, 1205 Geneva, Switzerland; Neuropsychology Unit, Department of Neurology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. Electronic address: julie.peron@unige.ch.
authors.forename: Julie
authors.initials: J
authors.lastname: Péron
authors.affiliation: Methodology and Data Analysis Unit, Department of Psychology, University of Geneva, 40 bd du Pont d'Arve, 1205 Geneva, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaud
authors.affiliation: Neurosurgery Department, Pontchaillou Hospital, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France; INSERM, LTSI U1099, Faculty of Medicine, CS 34317, University of Rennes I, F-35042 Rennes, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Haegelen
authors.affiliation: Neuropsychology Unit, Department of Neurology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.
authors.forename: Lucas
authors.initials: L
authors.lastname: Tamarit
authors.affiliation: 'Neuroscience of Emotion and Affective Dynamics' Laboratory, Department of Psychology & Swiss Center for Affective Sciences, University of Geneva, 40 bd du Pont d'Arve, 1205 Geneva, Switzerland; Neuropsychology Unit, Department of Neurology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.
authors.forename: Valérie
authors.initials: V
authors.lastname: Milesi
authors.affiliation: 'Behavior and Basal Ganglia' Research Unit (EA 4712), University of Rennes 1, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France; Neurology Department, Pontchaillou Hospital, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Houvenaghel
authors.affiliation: 'Behavior and Basal Ganglia' Research Unit (EA 4712), University of Rennes 1, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France; Neurology Department, Pontchaillou Hospital, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France; Adult Psychiatry Department, Guillaume Régnier Hospital, 108 avenue du Général Leclerc, 35703 Rennes, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Dondaine
authors.affiliation: 'Behavior and Basal Ganglia' Research Unit (EA 4712), University of Rennes 1, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France; Neurology Department, Pontchaillou Hospital, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Vérin
authors.affiliation: 'Behavior and Basal Ganglia' Research Unit (EA 4712), University of Rennes 1, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France; Physiology Department, Pontchaillou Hospital, Rennes University Hospital, rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Sauleau
authors.affiliation: 'Neuroscience of Emotion and Affective Dynamics' Laboratory, Department of Psychology & Swiss Center for Affective Sciences, University of Geneva, 40 bd du Pont d'Arve, 1205 Geneva, Switzerland; Neuropsychology Unit, Department of Neurology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.
authors.forename: Didier
authors.initials: D
authors.lastname: Grandjean
mesh_terms: D000786:Anger / Q000502:physiology; D046690:Deep Brain Stimulation / Q000379:methods; D004644:Emotions / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006240:Happiness; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology*; D010775:Photic Stimulation / Q000379:methods; D020531:Subthalamic Nucleus / Q000503:physiopathology*
keywords: Deep brain stimulation; Emotional prosody; Local field potentials; Parkinson’s disease; Subthalamic nucleus