title: Antiepileptic Drugs-induced Stevens-Johnson syndrome: A case Series.
abstract: Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with carbamazepine, oxcarbazepine, and phenytoin. To manage the reaction, the clinician withdrew the drug in all 8 cases, and in 1 case, the patient was shifted to valproate and symptomatic treatment was provided. There is still a controversy whether or not all AEDs can cause SJS. Recent studies have investigated the role of genetic factors - HLAB*502 allele in the development of AED-induced SJS in patients of Asian ancestry.
authors.affiliation: Department of Pharmacology, Smt. NHL Municipal Medical College, VS General Hospital, Ahmedabad, Gujarat, India.
authors.forename: Bhavi S
authors.initials: BS
authors.lastname: Trivedi
authors.affiliation: Department of Pharmacology, Smt. NHL Municipal Medical College, VS General Hospital, Ahmedabad, Gujarat, India.
authors.forename: Nishita H
authors.initials: NH
authors.lastname: Darji
authors.affiliation: Department of Pharmacology, Smt. NHL Municipal Medical College, VS General Hospital, Ahmedabad, Gujarat, India.
authors.forename: Supriya D
authors.initials: SD
authors.lastname: Malhotra
authors.affiliation: Department of Pharmacology, Smt. NHL Municipal Medical College, VS General Hospital, Ahmedabad, Gujarat, India.
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Patel
keywords: Adverse drug reactions; Stevens–Johnson syndrome; antiepileptic drug