title: The Effect of Sodium Hyaluronate on Ligamentation and Biomechanical Property of Tendon in Repair of Achilles Tendon Defect with Polyethylene Terephthalate Artificial Ligament: A Rabbit Tendon Repair Model.
abstract: The Achilles tendon is the most common ruptured tendon of human body. Reconstruction with polyethylene terephthalate (PET) artificial ligament is recommended in some serious cases. Sodium hyaluronate (HA) is beneficial for the healing of tendon injuries. We aimed to determine the effect of sodium hyaluronate in repair of Achilles tendon defect with PET artificial ligament in an animal tendon repair model. Sixteen New Zealand White rabbits were divided into two groups. Eight rabbits repaired with PET were assigned to PET group; the other eight rabbits repaired with PET along with injection of HE were assigned to HA-PET group. All rabbits were sacrificed at 4 and 8 weeks postoperatively for biomechanical and histological examination. The HA-PET group revealed higher biomechanical property compared with the PET group. Histologically, more collagen tissues grew into the HA-PET group compared with PET group. In conclusion, application of sodium hyaluronate can improve the healing of Achilles tendon reconstruction with polyethylene terephthalate artificial ligament.
authors.affiliation: Department of Sports Medicine, Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
authors.forename: Shengkun
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Sports Medicine, Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
authors.forename: Kui
authors.identifier: 0000-0002-1133-2479
authors.initials: K
authors.lastname: Ma
authors.affiliation: Department of Sports Medicine, Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
authors.forename: Hong
authors.identifier: 0000-0003-1243-5960
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Sports Medicine, Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Sports Medicine, Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
authors.forename: Shiyi
authors.initials: S
authors.lastname: Chen
mesh_terms: D000125:Achilles Tendon / Q000293:injuries* / Q000601:surgery; D000818:Animals; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D020007:Implants, Experimental; D008297:Male; D011093:Polyethylene Terephthalates / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D011093:Polyethylene Terephthalates; D006820:Hyaluronic Acid