title: Accumulation of DNA damage in the aged hematopoietic stem cell compartment.
abstract: Aging is associated with loss of functional potential of multiple tissue systems, and there has been significant interest in understanding how tissue-specific cells contribute to this decline. DNA damage accumulation has been widely associated with aging in differentiated cell types. However, tissue-specific stem cells were once thought to be a geno-protected population, as damage accrued in a stem cell population has the potential to be inherited by differentiated progeny, as well as propagated within the stem cell compartment through self-renewal divisions. This review will discuss the evidence for DNA damage accumulation in the aged HSC compartment, potential drivers, and finally the consequences of the acquired damage.
authors.affiliation: Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD. Electronic address: isabel.beerman@nih.gov.
authors.forename: Isabel
authors.initials: I
authors.lastname: Beerman
mesh_terms: D002454:Cell Differentiation; D016922:Cellular Senescence / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans
keywords: Aging; DNA damage; HSC; Hematopoietic stem cells