title: sta-1is repressed bymir-58family inCaenorhabditis elegans.
abstract: The miR-58 family comprises 6 microRNAs with largely shared functions, and with an overall high expression, because one of its members, miR-58, is the most abundant microRNA inCaenorhabditis elegans. We recently found that 2 TGF-β signaling pathways, Sma/Mab and Dauer, responsible for body size and dauer formation respectively, among other phenotypes, are downregulated by the miR-58 family. Here, we further explore this family by showing that it also acts through thesta-13'UTR.sta-1encodes a transcription factor, homologous to mammalian STATs, that inhibits dauer formation in association with the TGF-β Dauer pathway. We also observe that mutants with a constitutively active TGF-β Dauer pathway express higher levels ofsta-1mRNA. Our results reinforce the view of the miR-58 family and STA-1 as regulators of dauer formation in coordination with the TGF-β Dauer pathway.
authors.affiliation: Unidad Funcional de Investigación de Enfermedades Crónicas, Instituto de Salud Carlos III , Majadahonda, Madrid, Spain.
authors.forename: Encarnación
authors.initials: E
authors.lastname: Lozano
authors.affiliation: Unidad Funcional de Investigación de Enfermedades Crónicas, Instituto de Salud Carlos III , Majadahonda, Madrid, Spain.
authors.forename: María Pilar
authors.initials: MP
authors.lastname: de Lucas
authors.affiliation: Unidad Funcional de Investigación de Enfermedades Crónicas, Instituto de Salud Carlos III , Majadahonda, Madrid, Spain.
authors.forename: Alberto G
authors.initials: AG
authors.lastname: Sáez
keywords: Dauer; TGF-β Dauer; microRNAs; mir-58; sta-1