title: Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications.
abstract: Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity toward several cancerous cell lines. In particular, enhanced anticancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs. Finally, attractive two-photon absorbing properties further underlined the great significance of this PS for mitochondria targeted PDT applications in deep tissue cancer therapy.
authors.affiliation: Max-Planck-Institute for Polymer Research , Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Chakrabortty
authors.affiliation: Max-Planck-Institute for Polymer Research , Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Bikram Keshari
authors.initials: BK
authors.lastname: Agrawalla
authors.forename: Anne
authors.initials: A
authors.lastname: Stumper
authors.forename: Naidu M
authors.initials: NM
authors.lastname: Vegi
authors.forename: Stephan
authors.initials: S
authors.lastname: Fischer
authors.affiliation: Department of Functional Interfaces, Leibniz Institute of Photonic Technology (IPHT) Jena , Albert-Einstein-Straße 9, 07745 Jena, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Reichardt
authors.forename: Michael
authors.initials: M
authors.lastname: Kögler
authors.affiliation: Department of Functional Interfaces, Leibniz Institute of Photonic Technology (IPHT) Jena , Albert-Einstein-Straße 9, 07745 Jena, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dietzek
authors.affiliation: Department of Internal Medicine III, University Hospital Ulm , Albert-Einstein Allee 23, 89081, Ulm, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Feuring-Buske
authors.forename: Christian
authors.initials: C
authors.lastname: Buske
authors.forename: Sven
authors.initials: S
authors.lastname: Rau
authors.affiliation: Max-Planck-Institute for Polymer Research , Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Tanja
authors.identifier: 0000-0002-5906-7205
authors.initials: T
authors.lastname: Weil