title: Simamycin (5'-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp.
abstract: A new nucleoside modified by prenylation, simamycin (1), was isolated from the culture broth of a soil-derived Streptomyces sp. Its structure was determined by spectroscopic analysis and chemical synthesis as 5'-O-geranyluridine. Compound 1 induced differentiation of preadipocytes into matured adipocytes.
authors.affiliation: Department of Biotechnology, Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.affiliation: Department of Biotechnology, Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kyoso
authors.affiliation: Department of Biotechnology, Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
authors.forename: Youngju
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Nutritional Biochemistry, School of Nutrition and Dietetics, Kanagawa University of Human Services, Kanagawa, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oikawa
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D006801:Humans; D051379:Mice; D009705:Nucleosides / Q000302:isolation & purification / Q000494:pharmacology*; D054876:Prenylation; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D009705:Nucleosides; C000620673:simamycin