title: Protein-templated synthesis of metal-based nanomaterials.
abstract: There is currently intense interest in using protein scaffolds to prepare uniform nanometre-sized clusters of metals or other inorganic material for use as sensors, imaging agents, drugs, magnetic materials or catalysts. Non-templated chemical synthesis of such clusters often results in a product of variable size and quality, but protein molecules have proved adept at nucleating and stabilizing precise nanoclusters of various kinds. Although much research has focused on natural proteins, such as the iron-storage protein ferritin, recent developments in protein design have allowed entirely novel, symmetrical proteins to be used as templates for the first time.
authors.affiliation: Laboratory of Biomolecular Modelling and Design, KU Leuven, Celestijnenlaan 200G, 3001 Heverlee, Belgium.
authors.forename: Arnout Rd
authors.initials: AR
authors.lastname: Voet
authors.affiliation: Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro, Yokohama, Kanagawa 230-0045, Japan. Electronic address: jtame@tsurumi.yokohama-cu.ac.jp.
authors.forename: Jeremy Rh
authors.initials: JR
authors.lastname: Tame
mesh_terms: D060328:Magnetic Phenomena; D008670:Metals / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D014780:Viruses / Q000378:metabolism
chemical_list: D008670:Metals; D011506:Proteins