title: Correlation between bone marrow dose volumes and acute hematological toxicity in postoperative gynecological cancer patients.
abstract: OBJECTIVE
  To identify the association between radiation dose volume and acute hematological toxicity (HT) in postoperative gynecological cancer patients receiving whole pelvic radiotherapy (RT) or intensity-modulated RT (IMRT), a principal component regression model was used to calculate HT.
  
  
  METHODS
  Women (n=100) receiving with or without chemotherapy RT were retrospectively analyzed, 52 of whom received chemotherapy (paclitaxel and nedaplatin). The pelvis and lumbar vertebrae, defined as the prolong-pelvic bone marrow, were divided into the (1) combined ilium, ischium and pubis and the (2) lumbar vertebrae and the sacrum. The V5-V40 of subsides was calculated. The complete blood counts were recorded weekly. The principal component analysis was performed on volumes which generated the principal components (PCs), followed by using a logistic regression model.
  
  
  RESULTS
  Forty-seven patients presented with grade 2-3 HT during RT. Chemotherapy increased the incidence of HT compared with RT alone (70.21% vs. 29.79%; p=0.001). Fifty-three patients with persistent HT developed more serious HT at an earlier stage of RT. The chemotherapy cycles and three PCs associated with grade 2-3 HT was identified to form the resulting principal logistic regression model.
  
  
  CONCLUSIONS
  A new method to calculate the NTCP was achieved by PCs logistic regression.
authors.affiliation: Qian Li, Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, No.42, Baiziting, Xuanwu District, Nanjing, 210009, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Ming-Hua Jiang, Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, No.42, Baiziting, Xuanwu District, Nanjing, 210009, China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Jiang
authors.affiliation: Jing Chen, Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, No.42, Baiziting, Xuanwu District, Nanjing, 210009, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Wei Liu, Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, No.42, Baiziting, Xuanwu District, Nanjing, 210009, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Bi-Qing Zhu, Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, No.42, Baiziting, Xuanwu District, Nanjing, 210009, China.
authors.forename: Bi-Qing
authors.initials: BQ
authors.lastname: Zhu
authors.affiliation: E-Mei Lu, Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, No.42, Baiziting, Xuanwu District, Nanjing, 210009, China.
authors.forename: E-Mei
authors.initials: EM
authors.lastname: Lu
keywords: Chemotherapy; Intensity-modulated radiotherapy; Principal component analysis; Whole pelvic radiotherapy