title: Study on expression of CDH4 in lung cancer.
abstract: BACKGROUND
  The human CDH4 gene, which encodes the R-cadherin protein, has an important role in cell migration and cell adhesion, sorting, tissue morphogenesis, and tumor genesis. This study analyzed the relationship of CDH4 mRNA expression with lung cancer.
  
  
  METHODS
  Real time PCR was applied to detect CDH4 mRNA transcription in 142 paired cases of lung cancer and noncancerous regions.
  
  
  RESULTS
  No correlation was identified between CDH4 mRNA expression and gender, age, lymphnode metastasis, TNM stage, family history, smoking state, drinking state (P > 0.05), but grade and histotype (P < 0.05). The relative CDH4 mRNA value was remarkably decreased in lung cancer tissues compared with noncancerous tissues (P = 0.001).
  
  
  CONCLUSIONS
  We found that CDH4 mRNA expression was associated with grade and histotype. What is more, the relative CDH4 mRNA value was decreased in the lung cancer tissues. Our results suggested that CDH4 might be a putative tumor suppressor gene (TSG) in lung cancer.
authors.affiliation: Department of Cardiothoracic Surgery, Shaoxing People's Hospital, 568 Zhongxin Road, Shaoxing, Zhejiang, China.
authors.forename: Zhupeng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Cancer Research Institute, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou, Zhejiang, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Su
authors.affiliation: Cancer Research Institute, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou, Zhejiang, China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Ying
authors.affiliation: Department of Cardiothoracic Surgery, Shaoxing People's Hospital, 568 Zhongxin Road, Shaoxing, Zhejiang, China.
authors.forename: Guangmao
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou, Zhejiang, 310022, China. mwm1218@126.com.
authors.forename: Weimin
authors.initials: W
authors.lastname: Mao
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000556:secondary / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000556:secondary / Q000601:surgery; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D055752:Small Cell Lung Carcinoma / Q000235:genetics* / Q000556:secondary / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; C083970:R-cadherin
keywords: CDH4; Lung cancer; Tumor suppressor gene