title: Photoredox-catalysed redox-neutral trifluoromethylation of vinyl azides for the synthesis of α-trifluoromethylated ketones.
abstract: A redox-neutral, mild, and simple protocol is developed for the synthesis of α-trifluoromethylated ketones from vinyl azides under transition-metal-free conditions. In the presence of organic photoredox catalyst N-methyl-9-mesityl acridinium and sodium trifluoromethanesulfinate, a broad range of substituted vinyl azides were found to react smoothly upon visible-light irradiation, readily furnishing the corresponding products in satisfied yields.
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People's Republic of China. fliu2@suda.edu.cn.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Qin
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Wu
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Liu