title: p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker.
abstract: The p63 gene is often overexpressed in squamous cell carcinomas; however, how its overexpression contributes to tumor formation and expansion is still incompletely understood. Devos et al. report the development of a versatile mouse model demonstrating that p63 facilitates squamous cell carcinoma formation in skin and providing an excellent tool to dissect the relevance of its downstream signaling pathways in tumorigenesis.
authors.affiliation: CEINGE Biotecnologie Avanzate-Center for Genetic Engineering, Napoli, Italy; Department of Biology, University of Naples Federico II, Napoli, Italy. Electronic address: missero@ceinge.unina.it.
authors.forename: Caterina
authors.initials: C
authors.lastname: Missero
authors.affiliation: IRCCS SDN, Napoli, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Antonini
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell; D004268:DNA-Binding Proteins; D007150:Immunohistochemistry; D010750:Phosphoproteins; D013234:Stem Cells; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins