title: Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice.
abstract: The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC.
authors.affiliation: a IRCCS A.O.U. S. Martino-IST University Hospital , Genova , Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Astigiano
authors.affiliation: b Department of Experimental Medicine , University of Genova , Genova , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Puglisi
authors.affiliation: a IRCCS A.O.U. S. Martino-IST University Hospital , Genova , Italy.|c Department of Surgical and Diagnostic Science , University of Genova , Genova , Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Mastracci
authors.affiliation: d Department of Therapeutic Research and Medicines Evaluation , Istituto Superiore di Sanità (National Institute of Health) , Roma , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fais
authors.affiliation: a IRCCS A.O.U. S. Martino-IST University Hospital , Genova , Italy.|b Department of Experimental Medicine , University of Genova , Genova , Italy.
authors.forename: Ottavia
authors.initials: O
authors.lastname: Barbieri
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011471:Prostatic Neoplasms / Q000473:pathology*; D053219:Receptors, Tumor Necrosis Factor, Member 25 / Q000235:genetics; D059016:Tumor Microenvironment
chemical_list: D053219:Receptors, Tumor Necrosis Factor, Member 25; C506034:Tnfrsf25 protein, mouse
keywords: Alkalinisation; TRAMP mice; chemoprevention; prostate tumour; tumour microenvironment