title: Effects of pre-germinated brown rice treatment high-fat diet-induced metabolic syndrome in C57BL/6J mice.
abstract: To investigate using pre-germinated brown rice (PGBR) to treat metabolic syndrome, we fed one group of mice standard-regular-diet (SRD) for 20 weeks and another group of mice high-fat-diet (HFD) for 16 weeks. We subdivided them into HFD group and HFD + PGBR group whose dietary carbohydrate was replaced with PGBR for 4 weeks. The HFD group gained more weight, had higher blood pressure, heart rate, blood glucose and lipids, liver levels of TG, feces TG and bile acid, lower adipose levels of adipocytokine, lower skeletal muscle IR, IRS-1, IRS-2, PI3 K, Akt/PKB, GLUT-1, GLUT-4, GCK and PPAR-γ; higher liver SREBP-1, SCD-1, FAS, HMGCR, LDLR, CYP7α1 and PPAR-α, and higher adipose SREBP-1, SCD-1, FAS, and lower adipose PPAR-α and adiponectin. The HFD + PGBR group had clearly improved blood pressure, biochemical parameters and above proteins expressions. PGBR successful treatment of metabolic syndrome was achieved through improvements in glucose and lipid synthesis and metabolism.
authors.affiliation: a Division of Cardiology, Department of Internal Medicine , Kaohsiung Medical University Hospital , Kaohsiung , Taiwan.
authors.forename: Hsueh-Wei
authors.initials: HW
authors.lastname: Yen
authors.affiliation: b Department of Food Science and Nutrition , Meiho University , Pingtung , Taiwan.
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Lin
authors.affiliation: c Division of Cardiology, Department of Internal Medicine , Pingtung Christian Hospital , Pingtung , Taiwan.
authors.forename: Chi-Long
authors.initials: CL
authors.lastname: Hao
authors.affiliation: d Department of Chemistry , National Cheng-Kung University , Tainan , Taiwan.
authors.forename: Fu-Chih
authors.initials: FC
authors.lastname: Chen
authors.affiliation: e MS program for Applied Health and Biotechnology , Meiho University , Pingtung , Taiwan.
authors.forename: Chun-Yun
authors.initials: CY
authors.lastname: Chen
authors.affiliation: e MS program for Applied Health and Biotechnology , Meiho University , Pingtung , Taiwan.
authors.forename: Jia-Hao
authors.initials: JH
authors.lastname: Chen
authors.affiliation: f Department of Nursing , Meiho University , Pingtung , Taiwan.
authors.forename: Kuo-Ping
authors.initials: KP
authors.lastname: Shen
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects*; D005243:Feces / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects; D018525:Germination; D006339:Heart Rate / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D024821:Metabolic Syndrome / Q000097:blood / Q000139:chemically induced* / Q000178:diet therapy* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D012275:Oryza; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D054392:Adipokines; D001647:Bile Acids and Salts; D001786:Blood Glucose; D014280:Triglycerides
keywords: C57BL/6J mice; glucose and lipid synthesis and metabolism; metabolic syndrome; pre-germinated brown rice