title: Staphylococcus aureus screening and decolonization reduces the risk of surgical site infections in patients undergoing deep brain stimulation surgery.
abstract: In a controlled before-and-after study in a single centre, it was aimed to determine whether identification of Staphylococcus aureus nasal carriers followed by nasal mupirocin ointment and chlorhexidine soap reduced surgical site infections (SSIs) among 182 patients undergoing deep brain stimulation. In all, 119 patients were included in the control group and 63 in the screening group. There was a significant SSI decrease from 10.9% to 1.6% between the two groups (P<0.04; relative risk: 0.13; 95% confidence interval: 0.003-0.922). There were eight SSIs involving S. aureus in the control group, none in the screening group. No specific risk factors for SSI were identified.
authors.affiliation: Department of Neurosurgery, Pontchaillou University Hospital, Rennes, France. Electronic address: Jean.LEFEBVRE@chu-rennes.fr.
authors.forename: J
authors.initials: J
authors.lastname: Lefebvre
authors.affiliation: Department of Hospital Infection Control, Pontchaillou University Hospital, Rennes, France.
authors.forename: S
authors.initials: S
authors.lastname: Buffet-Bataillon
authors.affiliation: Department of Neurosurgery, Pontchaillou University Hospital, Rennes, France.
authors.forename: P L
authors.initials: PL
authors.lastname: Henaux
authors.affiliation: Department of Neurosurgery, Pontchaillou University Hospital, Rennes, France.
authors.forename: L
authors.initials: L
authors.lastname: Riffaud
authors.affiliation: Department of Neurosurgery, Pontchaillou University Hospital, Rennes, France.
authors.forename: X
authors.initials: X
authors.lastname: Morandi
authors.affiliation: Department of Neurosurgery, Pontchaillou University Hospital, Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Haegelen
mesh_terms: D000328:Adult; D000368:Aged; D002353:Carrier State / Q000175:diagnosis* / Q000188:drug therapy; D002710:Chlorhexidine / Q000008:administration & dosage; D065187:Controlled Before-After Studies; D046690:Deep Brain Stimulation; D004202:Disinfectants / Q000008:administration & dosage; D005260:Female; D006801:Humans; D017053:Infection Control / Q000379:methods*; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data; D008875:Middle Aged; D016712:Mupirocin / Q000008:administration & dosage; D011300:Preoperative Care / Q000379:methods*; D012915:Soaps / Q000008:administration & dosage; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D004202:Disinfectants; D012915:Soaps; D016712:Mupirocin; D002710:Chlorhexidine
keywords: Deep brain stimulation; Screening; Staphylococcus aureus; Surgical site infection