title: Pyrimidine non-nucleoside analogs: A direct synthesis of a novel class of N-substituted amino and N-sulfonamide derivatives of pyrimidines.
abstract: A convenient method for the regioselective synthesis of pyrimidine non-nucleoside analogs was developed. This study reports a novel and efficient method for the synthesis of a new type of N-substituted amino methylsulfanylpyrimidines and the corresponding pyrazolo[3,4-d]pyrimidines. This series of compounds was designed through the reaction of dimethyl N-cyanodithioiminocarbonate with 2-cyano-N'-(thiophen-2-yl-, furan-2-yl- and pyridin-4-ylmethylene)acetohydrazide and N'-(2-cyanoacetyl)arylsulfonohydrazides. The scope and limitation of the method are demonstrated. The antibacterial and antifungal activities of the synthesized compounds were also evaluated.
authors.affiliation: a Chemistry Department , Faculty of Science, Helwan University , Helwan , Cairo , Egypt.
authors.forename: Galal H
authors.initials: GH
authors.lastname: Elgemeie
authors.affiliation: a Chemistry Department , Faculty of Science, Helwan University , Helwan , Cairo , Egypt.
authors.forename: Ali M
authors.initials: AM
authors.lastname: Salah
authors.affiliation: a Chemistry Department , Faculty of Science, Helwan University , Helwan , Cairo , Egypt.|b Chemistry Department , Faculty of Science, Taibah University , Saudi Arabia.
authors.forename: Nermeen S
authors.initials: NS
authors.lastname: Abbas
authors.affiliation: c Photochemistry Department, National Research Center , Dokki , Cairo , Egypt.
authors.forename: Hoda A
authors.initials: HA
authors.lastname: Hussein
authors.affiliation: c Photochemistry Department, National Research Center , Dokki , Cairo , Egypt.
authors.forename: Reham A
authors.initials: RA
authors.lastname: Mohamed
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis*; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011743:Pyrimidines; D013449:Sulfonamides
keywords: 2-cyano-N′-(thiophen-2-yl-, furan-2-yl- and pyridin-4-ylmethylene)acetohydrazide; N-substituted amino methylsulfanylpyrimidines; N′-(2-cyanoacetyl)arylsul-fonohydrazides; antibacterial and antifungal activities; dimethyl N-cyanodithioiminocarbonate; pyrazolo[3,4-d]pyrimidines, purine analogs