title: The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research.
abstract: While significant medical breakthroughs have been achieved through using animal models, our experience shows that often there is surplus material remaining that is frequently never revisited but could be put to good use by other scientists. Recognising that most scientists are willing to share this material on a collaborative basis, it makes economic, ethical, and academic sense to explore the option to utilise this precious resource before generating new/additional animal models and associated samples. To bring together those requiring animal tissue and those holding this type of archival material, we have devised a framework called Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) with the aim of making remaining material derived from animal studies in biomedical research more visible and accessible to the scientific community. We encourage journals, funding bodies, and scientists to unite in promoting a new way of approaching animal research by adopting the SEARCH framework.
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom.
authors.forename: Bethny
authors.initials: B
authors.lastname: Morrissey
authors.affiliation: Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
authors.forename: Karen
authors.initials: K
authors.lastname: Blyth
authors.affiliation: Barts Cancer Institute, London, United Kingdom.
authors.forename: Phil
authors.initials: P
authors.lastname: Carter
authors.affiliation: Barts Cancer Institute, London, United Kingdom.
authors.forename: Claude
authors.initials: C
authors.lastname: Chelala
authors.affiliation: Barts Cancer Institute, London, United Kingdom.
authors.forename: Louise
authors.initials: L
authors.lastname: Jones
authors.affiliation: Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Ingunn
authors.initials: I
authors.lastname: Holen
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom.
authors.forename: Valerie
authors.initials: V
authors.lastname: Speirs
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D035843:Biomedical Research / Q000639:trends; D006801:Humans; D020407:Internet; D011795:Surveys and Questionnaires; D006113:United Kingdom; D023041:Xenograft Model Antitumor Assays