title: Transition-Metal-Free Amination of Pyridine-2-sulfonyl Chloride and Related N-Heterocycles Using Magnesium Amides.
abstract: A new transition-metal-free amination of pyridine-2-sulfonyl chloride and related N-heterocycles using magnesium amides of type R2NMgCl·LiCl is reported. Additionally, the directed ortho-magnesiation of pyridine-2-sulfonamides using TMPMgCl·LiCl was investigated. Reaction of the magnesium intermediates with various electrophiles and subsequent amination using magnesium amides led to a range of 2,3-functionalized pyridines. Also, cyclization reactions providing an aza-indole and an aza-carbazole were carried out.
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Balkenhohl
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Cyril
authors.initials: C
authors.lastname: François
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Sustac Roman
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Pauline
authors.initials: P
authors.lastname: Quinio
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F, 81377 Munich, Germany.
authors.forename: Paul
authors.identifier: 0000-0001-7913-4332
authors.initials: P
authors.lastname: Knochel