title: Association between previous spontaneous abortion and pre-eclampsia during a subsequent pregnancy.
abstract: OBJECTIVE
  To determine the impact of a history of spontaneous abortion on pre-eclampsia during a subsequent pregnancy.
  
  
  METHODS
  A cross-sectional study enrolled pregnant women admitted to obstetrics and gynecology wards at 103 hospitals in Tehran, Iran for delivery between July 6 and July 21, 2015. Consenting participants were interviewed by midwives; data were collected using a five-part questionnaire and patients' medical records were retrieved. Patient data were analyzed by multiple logistic regression to identify variables associated with increased odds of pre-eclampsia.
  
  
  RESULTS
  In total, 5170 patients were interviewed and 252 had experienced pre-eclampsia. The number of previous spontaneous abortions was found to be associated with pre-eclampsia, and a higher number of previous spontaneous abortions was associated with increased odds of patients having experienced pre-eclampsia (adjusted odds ratio 1.28, 95% confidence interval 1.03-1.59; P=0.025).
  
  
  CONCLUSIONS
  A history of spontaneous abortion was associated with increased odds of pre-eclampsia during a subsequent pregnancy.
authors.affiliation: Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Sepidarkish
authors.affiliation: Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Almasi-Hashiani
authors.affiliation: Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
authors.forename: Saman
authors.initials: S
authors.lastname: Maroufizadeh
authors.affiliation: Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
authors.forename: Samira
authors.initials: S
authors.lastname: Vesali
authors.affiliation: Division of Perinatology, Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Reihaneh
authors.initials: R
authors.lastname: Pirjani
authors.affiliation: Division of Perinatology, Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Reza O
authors.initials: RO
authors.lastname: Samani
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects*; D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006761:Hospitals; D006801:Humans; D007492:Iran; D016015:Logistic Models; D016017:Odds Ratio; D010298:Parity; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
keywords: Adverse perinatal outcomes; Pre-eclampsia; Spontaneous abortion