title: A green one-pot three-component cascade reaction: the synthesis of 2-amino-5,8-dihydro-3H-pyrido[2,3-D]pyrimidin-4-ones in aqueous medium.
abstract: A one-pot three-component cascade reaction for the green synthesis of a new class of 2-amino-5,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-ones was developed from the condensation of aromatic aldehydes with 2,6-diaminopyrimidin-4(3H)-one and acetophenone derivatives or various cyclic ketones in the presence of a catalytic amount of sodium carbonate in a mixture of water and ethanol at 60  [Formula: see text]. This reaction led to the construction of two carbon-carbon bonds and one carbon-nitrogen bond in a single synthetic step.
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran. a-shaabani@sbu.ac.ir.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shaabani
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
authors.forename: Heshmatollah
authors.initials: H
authors.lastname: Sepahvand
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
authors.forename: Mahmoud Borjian
authors.initials: MB
authors.lastname: Boroujeni
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
authors.forename: Mohammad Tayeb
authors.initials: MT
authors.lastname: Faroghi
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D002384:Catalysis; D055772:Green Chemistry Technology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D011743:Pyrimidines; D012997:Solvents; D014867:Water; C038699:acetophenone
keywords: 2, 6-Diaminopyrimidin-4(3H)-one; Acetophenone; Dihydropyridopyrimidine; Green synthesis; MCR; Three-component reaction