title: Vascular Adaptations to Habitual Exercise in Older Adults: Time for the Sex Talk.
abstract: Regular exercise is promoted as a therapeutic strategy for age-associated endothelial dysfunction. Improvements in endothelial function are observed with endurance exercise in older men, but are diminished or absent in older women. This article examines the hypothesis that sex hormones modulate vascular adaptations to exercise training by influencing antioxidant defense systems, mitochondrial function, oxidative stress, and intracellular signaling.
authors.affiliation: 1Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora; 2Denver Veterans Administration Medical Center, Geriatric Research, Education and Clinical Center, Denver, CO; and 3Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL.
authors.forename: Kerrie L
authors.initials: KL
authors.lastname: Moreau
authors.forename: Cemal
authors.initials: C
authors.lastname: Ozemek
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000502:physiology*; D004967:Estrogens / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D012737:Sex Factors
chemical_list: D004967:Estrogens; D012739:Gonadal Steroid Hormones