title: Hepatitis B virus in drug users in France: prevalence and vaccination history, ANRS-Coquelicot Survey 2011-2013.
abstract: People who use drugs (PWUD) are a key population for hepatitis B virus (HBV) vaccination and screening. We aimed to estimate the seroprevalence of HBs antigen (HBsAg) and self-reported HBV vaccination history in French PWUD attending harm reduction centres using data from the ANRS-Coquelicot multicentre survey conducted in 2011-2013 in 1718 PWUD. Self-fingerprick blood samples were collected on dried blood spots to detect the presence of HBsAg. HBsAg seroprevalence was estimated at 1·4% [95% confidence interval (CI) 0·8-2·5]. It varied between PWUD born in high (7·6%, 95% CI 2·7-19·1), moderate (2·2%, 95% CI 0·8-5·7) and low (0·7%, 95% CI 0·3-1·5) endemic zones. Factors independently associated with HBsAg carriage were being born in a moderate or high endemic zone or reporting precarious housing. Self-reported HBV vaccination history varied from 47·4% in high endemic zones, to 59·3% and 62·6% for moderate and low endemic zones, respectively. Our results suggest that drug use plays a small and substantial role, respectively, in HBsAg carriage in PWUD born in high/moderate and low endemic zones.
authors.affiliation: Santé publique France,Direction des Maladies Infectieuses,Saint-Maurice,France.
authors.forename: C
authors.initials: C
authors.lastname: Brouard
authors.affiliation: Santé publique France,Direction des Maladies Infectieuses,Saint-Maurice,France.
authors.forename: J
authors.initials: J
authors.lastname: Pillonel
authors.affiliation: Université Paris Descartes,Paris,France.
authors.forename: P
authors.initials: P
authors.lastname: Sogni
authors.affiliation: Cermes3,Inserm U988,UMR CNRS 8211,Université Paris Descartes,EHESS,Paris,France.
authors.forename: A
authors.initials: A
authors.lastname: Chollet
authors.affiliation: Centre for Health and Infectious Disease Research and WHO Collaborating Centre on HIV and Viral Hepatitis,Rigshospitalet,University of Copenhagen,Copenhagen,Denmark.
authors.forename: J V
authors.initials: JV
authors.lastname: Lazarus
authors.affiliation: Cermes3,Inserm U988,UMR CNRS 8211,Université Paris Descartes,EHESS,Paris,France.
authors.forename: X
authors.initials: X
authors.lastname: Pascal
authors.affiliation: Inserm U966,Centre National de Référence du VIH,CHU Bretonneau,Université François-Rabelais,Tours,France.
authors.forename: F
authors.initials: F
authors.lastname: Barin
authors.affiliation: Santé publique France,Direction des Maladies Infectieuses,Saint-Maurice,France.
authors.forename: M
authors.initials: M
authors.lastname: Jauffret-Roustide
keywords: Estimating; France; hepatitis B; people who use drugs (PWUD); prevalence of disease; vaccination (immunization)