title: Direct N-H/α,α,β,β-C(sp3)-H functionalization of piperidine via an azomethine ylide route: synthesis of spirooxindoles bearing 3-substituted oxindoles.
abstract: A protocol for the direct functionalization of N-H/α,α,β,β-C(sp3)-H of piperidine without any metal or external oxidants is reported. This reaction is promoted by 4-(trifluoromethyl)benzoic acid via an azomethine ylide intermediate. This is a simple method for the synthesis of spirooxindoles bearing 3-substituted oxindole moieties.
authors.affiliation: Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering Tianjin University of Technology, Tianjin 300384, P. R. China. aiminyu@tjut.edu.cn mengxiangtai23@mail.nankai.edu.cn.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Du
authors.affiliation: Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering Tianjin University of Technology, Tianjin 300384, P. R. China. aiminyu@tjut.edu.cn mengxiangtai23@mail.nankai.edu.cn.
authors.forename: Aimin
authors.initials: A
authors.lastname: Yu
authors.affiliation: Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering Tianjin University of Technology, Tianjin 300384, P. R. China. aiminyu@tjut.edu.cn mengxiangtai23@mail.nankai.edu.cn.
authors.forename: Jiru
authors.initials: J
authors.lastname: Jia
authors.affiliation: Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering Tianjin University of Technology, Tianjin 300384, P. R. China. aiminyu@tjut.edu.cn mengxiangtai23@mail.nankai.edu.cn.
authors.forename: Youquan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering Tianjin University of Technology, Tianjin 300384, P. R. China. aiminyu@tjut.edu.cn mengxiangtai23@mail.nankai.edu.cn.
authors.forename: Xiangtai
authors.identifier: http://orcid.org/0000-0003-2713-0078
authors.initials: X
authors.lastname: Meng