title: Effect of IL-17 in the development of colon cancer in mice.
abstract: Cytokine therapy is commonly used for tumor immunotherapy. Although early studies focused directly on the tumor, current investigations are more attentive of the tumor microenvironment. Various immune cells and related cytokines in the tumor microenvironment play an important role in the occurrence and development of tumor. Interleukin (IL)-17 is the characteristic cytokine produced by Th17 cells. IL-17 has been associated with various immune responses. The results of previous studies showed that IL-17 can significantly reduce the size of transplanted tumors in tumor-bearing mice, albeit it has no effect on the survival time of mice. By investigating the effect of IL-17 in the number and distribution of lymphocyte infiltration in tumor tissues, the expression of cytokines and transcription factors associated with the subsets of CD4+T cells in tumor tissues, the distribution of subsets of spleen lymphocyte in tumor-bearing mice, a preliminary investigation of the possible antitumor mechanism of IL-17 was performed. In conclusion, the antitumor effect ofIL-17gene transfection in the colon cancer of mice may be associated with the mechanisms wherebyIL-17gene transfection can change the distribution of different subsets of spleen lymphocytes in mice.IL-17gene transfection can increase the number of lymphocyte infiltration in tumor tissues.IL-17gene transfection can promote the high expression of interferon-γ in tumor tissue, while reducing the expression of IL-10 and IL-13 factors, thus exerting an antitumor effect.
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China; The Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei 050017, P.R. China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of the Nuclear Medicine, The First Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: The Second Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Nursing, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Electroencephalogram, Xingtai People's Hospital, Xingtai, Hebei 054031, P.R. China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Pathogenic Biology and Immunology, Cangzhou Medical College, Cangzhou, Hebei 061001, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China; The Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei 050017, P.R. China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China.
authors.forename: Quanhai
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Qi
keywords: colon cancer; cytokine therapy; interleukin-17