title: Four-Step Total Synthesis of Selaginpulvilin D.
abstract: An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.
authors.affiliation: Research School of Chemistry, Australian National University , Canberra, ACT 2601, Australia.
authors.forename: Madison J
authors.initials: MJ
authors.lastname: Sowden
authors.affiliation: Research School of Chemistry, Australian National University , Canberra, ACT 2601, Australia.
authors.forename: Michael S
authors.identifier: 0000-0001-5098-0703
authors.initials: MS
authors.lastname: Sherburn