title: MicroRNA: Defining a new niche in Leukemia.
abstract: MicroRNAs (miRNAs) are endogenous short non-coding RNAs found to play key roles in the pathogenesis of leukemia. Apart from being traditionally identified as modulators of oncogenes, the potential roles of miRNAs seems to be growing with novel and recent findings among different subtypes of hematological malignancies. Leukemia is one of the earliest malignancies to be linked to abnormal expression of miRNAs. However, a clear understanding of the involvement of miRNAs in intricate mechanisms of leukemogenesis is still a necessity. This review summarizes the multiple roles of miRNAs in the pathogenesis of leukemia and highlights major research findings contributing to these aspects.
authors.affiliation: Hamad Medical Corporation, P.O. Box 4572, Doha, Qatar. Electronic address: queenie.fernandez@gmail.com.
authors.forename: Queenie
authors.initials: Q
authors.lastname: Fernandes
mesh_terms: D000818:Animals; D015415:Biomarkers; D015973:Gene Expression Regulation, Leukemic; D015316:Genetic Therapy / Q000379:methods; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D034622:RNA Interference; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Biomarkers; Leukemia; MicroRNAs