title: Specificity of Mechanisms of Memory Reconsolidation in Snails Trained for Rejection of Two Types of Food.
abstract: Specificity of behavioral and neuronal mechanisms of impairment of long-term memory reconsolidation was studied in edible snails trained for associative skill of rejection of two types of food: raw carrots (conditioned stimulus 1) and apple (conditioned stimulus 2). In 2 days after training, the snails received protein synthesis inhibitor cycloheximide and a reminder (conditioned stimulus 1 or 2). In 3 and 14 days after cycloheximide/reminder, we observed the absence of aversive responses to the conditioned stimulus used as the reminder and preserved responses to the conditioned stimulus not used as the reminder. Moreover, we observed specific suppression of synaptic responses of command neurons of snail defensive behavior induced by the conditioned stimulus used as the reminder after cycloheximide injection and preserved synaptic responses of neurons to the other conditioned stimulus. It was hypothesized that protein synthesis-dependent synapse-specific plasticity of command neurons can be a mechanism of selective preservation of conditioned food aversion memory in snails.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. nikitin.vp@mail.ru.
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Kozyrev
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Solntseva
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003513:Cycloheximide / Q000494:pharmacology; D018552:Daucus carota; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology*; D027845:Malus; D000069077:Memory Consolidation / Q000187:drug effects* / Q000502:physiology; D057567:Memory, Long-Term / Q000187:drug effects* / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide
keywords: amnesia; edible snail; memory reconsolidation; protein synthesis; synapse-specific plasticity