title: Takayasu's Arteritis with Isolated Pulmonary Artery Involvement in a Middle-Aged Asian Woman with Hepatitis B and Latent Tuberculosis Infection.
abstract: We report a rare case of Takayasu's arteritis with isolated pulmonary artery stenosis in the presence of active hepatitis B and latent Mycobacterium tuberculosis infection in a middle-aged Asian woman who initially presented with severe dyspnea on exertion and recurrent syncope, occasional burning chest pains, and fatigue. Therapy of the active hepatitis B and latent M. tuberculosis infection together with a course of methotrexate led to a slight reversal of the symptoms, as angioplasty with or without stenting was not an option. The constellation described here hints at the possible link between hepatitis B and M. tuberculosis infection and the development of Takayasu's arteritis. The case also supports the little evidence available indicating that treatment of active hepatitis B infection could positively influence the course of Takayasu's arteritis.
authors.affiliation: Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Felix
authors.initials: F
authors.lastname: Liebscher
authors.forename: Thomas
authors.initials: T
authors.lastname: Pfammatter
authors.forename: Antonios
authors.initials: A
authors.lastname: Kolios
authors.forename: Matthias
authors.initials: M
authors.lastname: Greutmann
authors.forename: Daniel
authors.initials: D
authors.lastname: Franzen
mesh_terms: D015901:Angiography, Digital Subtraction; D000995:Antitubercular Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D019788:Fluorodeoxyglucose F18; D005938:Glucocorticoids / Q000627:therapeutic use; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007538:Isoniazid / Q000627:therapeutic use; D055985:Latent Tuberculosis / Q000150:complications* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011651:Pulmonary Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals; D012008:Recurrence; D000071079:Stenosis, Pulmonary Artery / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013625:Takayasu Arteritis / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D000998:Antiviral Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C413685:entecavir; D006147:Guanine; D001379:Azathioprine; D007538:Isoniazid; D008727:Methotrexate