title: Childhood trauma, depression and negative symptoms are independently associated with impaired quality of life in schizophrenia. Results from the national FACE-SZ cohort.
abstract: Depression and negative symptoms have been associated with impaired Quality of life (QoL) in schizophrenia (SZ). However, childhood trauma may influence both QoL and depression in SZ patients, with consequences for the management of impaired QoL in SZ patients. The aim of the present study was to determine if childhood trauma was associated with impaired QoL in schizophrenia.
  
  
  
  A sample of 544 community-dwelling stabilized SZ patients enrolled in FACE-SZ cohort were utilized in this study (74.1% males, mean aged 32.3years, mean illness duration 10.6years). QoL was self-reported with the S-QoL18 questionnaire. Childhood trauma was self-reported with the Childhood Trauma Questionnaire. Depression was measured by the Calgary Depression Rating Scale for Schizophrenia. Psychotic severity was measured by the Positive and Negative Syndrome Scale for Schizophrenia (PANSS). Other clinical factors, treatments, comorbidities, functioning and sociodemographical variables were also recorded, with validated scales.
  
  
  
  Overall, 151 participants (27.8%) had a current major depressive episode and 406 (82.5%) reported at least one episode of historical childhood trauma. In multivariate analyses, lower QoL total score was associated with a history of childhood trauma (β=-0.21, p<0.0001), psychotic negative symptoms (β=-0.11, p=0.04), current depression (β=-0.0.38, p<0.0001) and male gender (β=-0.16, p<0.0001).
  
  
  
  Impaired QoL is independently associated with negative symptoms, depression and childhood trauma in schizophrenia.
authors.affiliation: Fondation FondaMental, Créteil, France; INSERM U955, Translational Psychiatry team, Créteil, France, Université Paris-Est Créteil (UPEC), AP-HP, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Andrianarisoa
authors.affiliation: Fondation FondaMental, Créteil, France; Pôle psychiatrie universitaire, CHU Sainte-Marguerite, F-13274 Marseille cedex 09, France.
authors.forename: L
authors.initials: L
authors.lastname: Boyer
authors.affiliation: Fondation FondaMental, Créteil, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France, INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Godin
authors.affiliation: Fondation FondaMental, Créteil, France; INSERM U955, Translational Psychiatry team, Créteil, France, Université Paris-Est Créteil (UPEC), AP-HP, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France.
authors.forename: L
authors.initials: L
authors.lastname: Brunel
authors.affiliation: Fondation FondaMental, Créteil, France; INSERM U955, Translational Psychiatry team, Créteil, France, Université Paris-Est Créteil (UPEC), AP-HP, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France.
authors.forename: E
authors.initials: E
authors.lastname: Bulzacka
authors.affiliation: Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens, F-33076 Bordeaux, France; Université de Bordeaux, France; Inserm, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France.
authors.forename: B
authors.initials: B
authors.lastname: Aouizerate
authors.affiliation: Fondation FondaMental, Créteil, France; Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Berna
authors.affiliation: Fondation FondaMental, Créteil, France; Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France.
authors.forename: D
authors.initials: D
authors.lastname: Capdevielle
authors.affiliation: Fondation FondaMental, Créteil, France; AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Dorey
authors.affiliation: Fondation FondaMental, Créteil, France; AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France.
authors.forename: C
authors.initials: C
authors.lastname: Dubertret
authors.affiliation: Fondation FondaMental, Créteil, France; Assistance Publique des Hôpitaux de Marseille (AP-HM), pôle universitaire de psychiatrie, Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Dubreucq
authors.affiliation: Fondation FondaMental, Créteil, France; Assistance Publique des Hôpitaux de Marseille (AP-HM), pôle universitaire de psychiatrie, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Faget
authors.affiliation: Fondation FondaMental, Créteil, France; Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble, France.
authors.forename: F
authors.initials: F
authors.lastname: Gabayet
authors.affiliation: Fondation FondaMental, Créteil, France; CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France.
authors.forename: P M
authors.initials: PM
authors.lastname: Llorca
authors.affiliation: Fondation FondaMental, Créteil, France; AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France.
authors.forename: J
authors.initials: J
authors.lastname: Mallet
authors.affiliation: Fondation FondaMental, Créteil, France; CNRS UMR 5287-INCIA, France; CNRS UMR 5287-INCIA, France.
authors.forename: D
authors.initials: D
authors.lastname: Misdrahi
authors.affiliation: Fondation FondaMental, Créteil, France; Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier Pole Est BP 300 39 - 95 bd Pinel - 69678 BRON Cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Rey
authors.affiliation: Fondation FondaMental, Créteil, France; Assistance Publique des Hôpitaux de Marseille (AP-HM), pôle universitaire de psychiatrie, Marseille, France.
authors.forename: R
authors.initials: R
authors.lastname: Richieri
authors.affiliation: Fondation FondaMental, Créteil, France; Service de psychiatrie d'adulte, Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles, France.
authors.forename: C
authors.initials: C
authors.lastname: Passerieux
authors.affiliation: Fondation FondaMental, Créteil, France; Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Schandrin
authors.affiliation: CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France; Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier Pole Est BP 300 39 - 95 bd Pinel - 69678 BRON Cedex, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Tronche
authors.affiliation: Fondation FondaMental, Créteil, France; Service de psychiatrie d'adulte, Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles, France.
authors.forename: M
authors.initials: M
authors.lastname: Urbach
authors.affiliation: Fondation FondaMental, Créteil, France; Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Vidailhet
authors.affiliation: Fondation FondaMental, Créteil, France; INSERM U955, Translational Psychiatry team, Créteil, France, Université Paris-Est Créteil (UPEC), AP-HP, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France.
authors.forename: F
authors.initials: F
authors.lastname: Schürhoff
authors.affiliation: Fondation FondaMental, Créteil, France; Clinique Jeanne d'Arc, hôpital Privé Parisien, 55 rue du commandant Mouchotte, F-94160 Saint-Mandé, France; CHU Carémeau, Nîmes, France. Electronic address: guillaume.fond@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Fond
mesh_terms: D000328:Adult; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D015331:Cohort Studies; D003863:Depression / Q000209:etiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D011795:Surveys and Questionnaires
keywords: Childhood trauma; Depression; Negative symptoms; Quality of life; Schizophrenia