title: 3,4 Dihydroxycinnamic acid stimulates immune system function by modifying the humoral antibody response - An in vivo study.
abstract: The immunomodulatory property of 3,4-Dihydroxy-cinnamic acid (DCA) was studied under the normal and cyclophosphamide induced immunosuppressive conditions in animal models. The immunomodulatory activity was evaluated by studying the haematological parameters, humoral antibody, based on the plaque forming cell count, the bone marrow cellularity, the α-esterase's producing active cells, delayed type hypersensitive assay, phagocytic index assays. The chemopreventive effect of DCA was determined by cyclophosphamide induced immunosuppression in animals. From the response, DCA exhibits significant immunomodulatory activity by enhancing the humoral immune response. The histopathological investigation revealed the protective effect of DCA against cyclophosphamide induced immunosuppression. From the result it is observed that the DCA boosts up the immune system activity in a positive manner.
authors.affiliation: Department of Bioscience and Technology, School of Engineering and Technology, Karunya University, Karunya Nagar, Coimbatore 641114, India.
authors.forename: M
authors.initials: M
authors.lastname: Ishwarya
authors.affiliation: Department of Bioscience and Technology, School of Engineering and Technology, Karunya University, Karunya Nagar, Coimbatore 641114, India. Electronic address: bionaren_phd@yahoo.co.in.
authors.forename: R T
authors.initials: RT
authors.lastname: Narendhirakannan
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D003373:Coumaric Acids / Q000737:chemistry / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D019610:Cytoprotection; D064420:Drug-Related Side Effects and Adverse Reactions / Q000188:drug therapy*; D006968:Hypersensitivity, Delayed / Q000188:drug therapy*; D007107:Immune System / Q000187:drug effects*; D056724:Immunity, Humoral / Q000187:drug effects*; D007155:Immunologic Factors / Q000627:therapeutic use*; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects
chemical_list: D000906:Antibodies; D003373:Coumaric Acids; D007155:Immunologic Factors; D003520:Cyclophosphamide
keywords: 3,4 Dihydroxy-cinnamic acid; Humoral antibody; Hypersensitivity; Immunomodulatory