title: Rattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer's β-Amyloid Aggregation.
abstract: Rose bengal (RB)-loaded upconverting nanocomposites are synthesized as a near-infrared (NIR)-responsive inhibitor of Aβ aggregation. Rattle-structured, organosilica shell (ROS) is deposited on NaYF4:Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aβ self-assembly under NIR irradiation by generating1O2. Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aβ-induced cytotoxicity.
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
authors.forename: Sukeun
authors.initials: S
authors.lastname: Kuk
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
authors.forename: Byung Il
authors.initials: BI
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
authors.forename: Joon Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000818:Animals; D016923:Cell Death; D007259:Infrared Rays; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017646:Organosilicon Compounds / Q000737:chemistry; D016716:PC12 Cells; D066329:Protein Aggregates; D051381:Rats; D012395:Rose Bengal
chemical_list: D016229:Amyloid beta-Peptides; D017646:Organosilicon Compounds; D066329:Protein Aggregates; D012395:Rose Bengal
keywords: near-infrared light; photosensitizers; self-assembly; upconversion nanoparticles; β-amyloid