title: Effects of Opioid Peptides on Changes in Lipid Metabolism in Rats Subjected to Swimming Stress.
abstract: Blood levels of nonesterified fatty acids, total cholesterol, triglycerides, and LDL increased in rats subjected to forced swimming stress. Administration of opioid peptides dynorphin A(1-13), DSLET, or DAGO reduced stress-induced disturbances in lipid metabolism. Dynorphin A(1-13) and DAGO produced the most pronounced effects and prevented an increase in concentrations of nonesterified fatty acids, triglycerides, total cholesterol, and LDL as soon as 39 h after treatment. Only DSLET increased HDL content in the plasma of stressed rats. The observed effects can be explained by the stress-limiting effects of opioids, e.g. attenuation of the effect of catecholamines on the adipose tissue and inhibition of the generation LPO products suppressing activity of the cholesterol metabolizing enzyme.
authors.affiliation: Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. medps@yandex.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Solin
authors.affiliation: Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Lyashev
authors.affiliation: Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
authors.forename: Yu D
authors.initials: YD
authors.lastname: Lyashev
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004399:Dynorphins / Q000494:pharmacology*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D013550:Swimming; D014280:Triglycerides / Q000097:blood
chemical_list: D000701:Analgesics, Opioid; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; D010446:Peptide Fragments; D014280:Triglycerides; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; C054641:dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)-; D004743:Enkephalin, Leucine; D004399:Dynorphins; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; D002784:Cholesterol
keywords: lipid metabolism; opioid peptides; swimming stress