title: Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease.
abstract: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD).
  
  
  
  Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]. The data were evaluated with SPSS using "Student t and Mann-Whitney U" tests.
  
  
  
  The study group children (n: 43) had higher LDL, Lp(a) and ox-LDL levels, ratios of TC/HDL, Apo-B/A, LDL/HDL and ox-LDL/HDL (p<0.05) than control group.
  
  
  
  These findings suggest that dyslipidemia and increased LDL, Lp(a) and ox-LDL levels are common in the offspring of patients with early onset CHD and account largely for their familial predisposition for CHD.
authors.affiliation: Pediatric Cardiologist in Pediatric Cardiology Clinic, Sultan Süleyman Education and Research Hospital, Istanbul, Turkey.
authors.forename: Helen
authors.initials: H
authors.lastname: Bornaun
authors.affiliation: Pediatric Cardiology Department, Yeni Yüzyıl University, Istanbul, Turkey.nacioner@yahoo.com.
authors.forename: Naci
authors.initials: N
authors.lastname: Öner
authors.affiliation: Pediatric Cardiology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Nişli
authors.affiliation: Pediatric Cardiologist in Pediatric Cardiology Clinic, Sultan Süleyman Education and Research Hospital, Istanbul, Turkey.
authors.forename: Kazım
authors.initials: K
authors.lastname: Öztarhan
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Okan University, Istanbul, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Yavuz
authors.affiliation: Pediatric Cardiology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Türkoğlu
authors.affiliation: Pediatric Cardiology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Aygün
authors.initials: A
authors.lastname: Dindar
authors.affiliation: Pediatric Cardiology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Rukiye
authors.initials: R
authors.lastname: Eker Ömeroglu
mesh_terms: D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010290:Parents; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D001053:Apolipoproteins; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D014280:Triglycerides
keywords: children; coronary artery disease; lipids; offspring; risk factors