title: Changing Epidemiology of Human Brucellosis, China, 1955-2014.
abstract: Brucellosis, a zoonotic disease, was made statutorily notifiable in China in 1955. We analyzed the incidence and spatial-temporal distribution of human brucellosis during 1955-2014 in China using notifiable surveillance data: aggregated data for 1955-2003 and individual case data for 2004-2014. A total of 513,034 brucellosis cases were recorded, of which 99.3% were reported in northern China during 1955-2014, and 69.1% (258, 462/374, 141) occurred during February-July in 1990-2014. Incidence remained high during 1955-1978 (interquartile range 0.42-1.0 cases/100,000 residents), then decreased dramatically in 1979-1994. However, brucellosis has reemerged since 1995 (interquartile range 0.11-0.23 in 1995-2003 and 1.48-2.89 in 2004-2014); the historical high occurred in 2014, and the affected area expanded from northern pastureland provinces to the adjacent grassland and agricultural areas, then to southern coastal and southwestern areas. Control strategies in China should be adjusted to account for these changes by adopting a One Health approach.
authors.forename: Shengjie
authors.initials: S
authors.lastname: Lai
authors.forename: Hang
authors.initials: H
authors.lastname: Zhou
authors.forename: Weiyi
authors.initials: W
authors.lastname: Xiong
authors.forename: Marius
authors.initials: M
authors.lastname: Gilbert
authors.forename: Zhuojie
authors.initials: Z
authors.lastname: Huang
authors.forename: Jianxing
authors.initials: J
authors.lastname: Yu
authors.forename: Wenwu
authors.initials: W
authors.lastname: Yin
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.forename: Qiulan
authors.initials: Q
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Di
authors.initials: D
authors.lastname: Mu
authors.forename: Lingjia
authors.initials: L
authors.lastname: Zeng
authors.forename: Xiang
authors.initials: X
authors.lastname: Ren
authors.forename: Mengjie
authors.initials: M
authors.lastname: Geng
authors.forename: Zike
authors.initials: Z
authors.lastname: Zhang
authors.forename: Buyun
authors.initials: B
authors.lastname: Cui
authors.forename: Tiefeng
authors.initials: T
authors.lastname: Li
authors.forename: Dali
authors.initials: D
authors.lastname: Wang
authors.forename: Zhongjie
authors.initials: Z
authors.lastname: Li
authors.forename: Nicola A
authors.initials: NA
authors.lastname: Wardrop
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Tatem
authors.forename: Hongjie
authors.initials: H
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002006:Brucellosis / Q000453:epidemiology* / Q000266:history / Q000382:microbiology / Q000635:transmission; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D018563:Disease Notification; D004197:Disease Reservoirs; D005260:Female; D062305:Geographic Mapping; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012621:Seasons; D062211:Spatio-Temporal Analysis; D055815:Young Adult; D015047:Zoonoses / Q000453:epidemiology
keywords: Brucella; Brucellosis; China; bacteria; epidemiology; humans; zoonoses