title: Resisting the Urge to Act: DREADDs Modifying Habits.
abstract: Recently, Meyer and Bucci used chemogenetic technology - artificial excitatory and inhibitory receptors - to modulate neuronal activity in two connected brain regions in opposite directions simultaneously. This innovative manipulation revealed that the two regions studied, orbitofrontal cortex and nucleus accumbens, are not sequentially dependent during contextual decision-making.
authors.affiliation: Section on Neural Coding and Computation, Laboratory of Neuropsychology, Bldg 49, Rm 1B80, NIMH/NIH/DHHS, Bethesda, MD, USA. Electronic address: Mark.Eldridge@nih.gov.
authors.forename: Mark A G
authors.initials: MAG
authors.lastname: Eldridge
authors.affiliation: Section on Neural Coding and Computation, Laboratory of Neuropsychology, Bldg 49, Rm 1B80, NIMH/NIH/DHHS, Bethesda, MD, USA. Electronic address: Barry.Richmond@nih.gov.
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Richmond
mesh_terms: D000818:Animals; D006801:Humans; D003657:Decision Making / Q000502:physiology; D006184:Habits; D009415:Nerve Net / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology; D012201:Reward