title: Application of 3D and 2D quantitative shear wave elastography (SWE) to differentiate between benign and malignant breast masses.
abstract: As breast cancer tissues are stiffer than normal tissues, shear wave elastography (SWE) can locally quantify tissue stiffness and provide histological information. Moreover, tissue stiffness can be observed on three-dimensional (3D) colour-coded elasticity maps. Our objective was to evaluate the diagnostic performances of quantitative features in differentiating breast masses by two-dimensional (2D) and 3D SWE. Two hundred ten consecutive women with 210 breast masses were examined with B-mode ultrasound (US) and SWE. Quantitative features of 3D and 2D SWE were assessed, including elastic modulus standard deviation (ESDE) measured on SWE mode images and ESDUmeasured on B-mode images, as well as maximum elasticity (Emax). Adding quantitative features to B-mode US improved the diagnostic performance (p < 0.05) and reduced false-positive biopsies (p < 0.0001). The area under the receiver operating characteristic curve (AUC) of 3D SWE was similar to that of 2D SWE for ESDE(p = 0.026) and ESDU(p = 0.159) but inferior to that of 2D SWE for Emax(p = 0.002). Compared with ESDU, ESDEshowed a higher AUC on 2D (p = 0.0038) and 3D SWE (p = 0.0057). Our study indicates that quantitative features of 3D and 2D SWE can significantly improve the diagnostic performance of B-mode US, especially 3D SWE ESDE, which shows considerable clinical value.
authors.affiliation: Ultrasound Department, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Ultrasound Department, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Qianqi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Ultrasound Department, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Ultrasound Department, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xing
authors.affiliation: Endocrinology Department, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Zhuowen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Ultrasound Department, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Changjun
authors.initials: C
authors.lastname: Wu
mesh_terms: D000328:Adult; D001940:Breast / Q000000981:diagnostic imaging* / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*