title: The pretreatment thrombocytosis may predict prognosis of patients with colorectal cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Recently, several studies have reported that thrombocytosis may be associated with the poor prognosis of colorectal cancer (CRC). Nevertheless, their conclusions were still controversial. Results & methodology: We searched PubMed, Embase, Cochrane Library and Web of Science up to April 2016. A total of 30 studies including 9129 patients were included in this meta-analysis. Thrombocytosis had a close relationship with the poor overall survival of CRC compared with normal platelet counts, with the pooled hazard ratios being 1.89 (95% CI: 1.45-2.47; p < 0.00001) and 1.83 (95% CI: 1.33-2.53; p = 0.0002), with univariate and multivariate analyses, respectively.
  
  
  CONCLUSIONS
  This meta-analysis indicated that thrombocytosis may be a cost-effective and noninvasive indicator for poor prognosis of patients with CRC, especially for overall survival.
authors.affiliation: Department of General Surgery, The First People's Hospital of Xi'ning City, Xi'ning 810000, Qinghai Province, PR China.|Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Wang
authors.affiliation: The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.|Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Deng
authors.affiliation: Department of General Surgery, The First People's Hospital of Xi'ning City, Xi'ning 810000, Qinghai Province, PR China.
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Yang
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.affiliation: The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Jian-Meng
authors.initials: JM
authors.lastname: Zhao
authors.affiliation: The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.|Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Guang-Tao
authors.initials: GT
authors.lastname: Min
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Xu
authors.affiliation: The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Peng-Ying
authors.initials: PY
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Hong-Peng
authors.initials: HP
authors.lastname: Wang
authors.affiliation: The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D016208:Databases, Factual; D018572:Disease-Free Survival; D006801:Humans; D015999:Multivariate Analysis; D016017:Odds Ratio; D010976:Platelet Count; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D015996:Survival Rate; D013922:Thrombocytosis / Q000150:complications / Q000628:therapy*
keywords: colorectal cancer; meta-analysis; platelet counts; prognosis; thrombocytosis