title: Dietary Fat Consumption and Non-Hodgkin's Lymphoma Risk: A Meta-analysis.
abstract: Many studies suggest that high-fat diets are linked to the etiology of non-Hodgkin's lymphoma (NHL). However, the findings are inconsistent and therefore the association between fat and non-Hodgkin's lymphoma remains unclear. In this study, we aim to quantitatively assess the association between fat consumption and the risk for NHL.
  
  
  
  We reviewed 221 published cohort and case-control studies that reported relative risk (RRs) and corresponding 95% confidence intervals (CIs) of NHL and fat intake using PubMed, Cochrane, EMBASE, and Google Scholar databases. A random-effects model computed summary risk estimates.
  
  
  
  Based on our literature search, 10 of 221 studies (two cohort and eight case-control studies) were relevant to this meta-analysis. There was a significant association between total fat consumption and increased risk of NHL (RR = 1.26; 95% CI: 1.12-1.42); in addition, subgroup analysis showed a significant correlation with diffuse large B-cell lymphoma (RR = 1.41; 95% CI: 1.08-1.84) but not with follicular lymphoma (RR = 1.21; 95% CI: 0.97-1.52), small lymphocytic lymphoma/chronic lymphocytic leukemia (RR = 0.91; 95% CI: 0.68-1.23), nor with T cell lymphoma (RR = 1.12; 95% CI: 0.60-2.09). The funnel plot revealed no evidence for publication bias.
  
  
  
  Total fat consumption, particularly animal fat, increases the risk for NHL.
authors.affiliation: a Department of Hematology , Shandong Provincial Hospital, Shandong University , Tai'an , China.|b Department of Hematology , Tai'an Central Hospital , Tai'an , China.
authors.forename: Tian-Jie
authors.initials: TJ
authors.lastname: Han
authors.affiliation: c Department of Gastroenterology , Shandong Provincial Hospital, Shandong University , Tai'an , China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Li
authors.affiliation: d Department of Pathology , Tai'an Central Hospital , Tai'an , China.
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Luan
authors.affiliation: b Department of Hematology , Tai'an Central Hospital , Tai'an , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: a Department of Hematology , Shandong Provincial Hospital, Shandong University , Tai'an , China.
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Xu
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000473:pathology; D012307:Risk Factors; D014675:Vegetables
chemical_list: D004041:Dietary Fats