title: Quantitative analysis combined with chromatographic fingerprint and antioxidant activities for the comprehensive evaluation of Compound Danshen Tablets.
abstract: The composition of traditional Chinese medicine is extremely complex, so it is difficult to ensure quality consistency. We took Compound Danshen Tablets as the object of the study, by using high-performance liquid chromatography to establish multiwavelength fusion fingerprints. Characteristic fingerprints of 30 batches of samples were generated at four wavelengths and evaluated by systematic quantified fingerprint method. An on-line antioxidant determination method was used for the determination of the antioxidant components in Compound Danshen Tablets. The fingerprint analysis of the marker compounds can reflect the content of the marker compounds, which were determined by using the external standard method. This study elucidated that multiwavelength fusion fingerprint profiles and multiple markers compound analysis in conjunction with the assay of antioxidant activity offered a reliable and efficient approach to quantitatively evaluate the quality consistency of the traditional Chinese medicine and herbal preparations.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P.R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P.R. China.
authors.forename: Jiayue
authors.initials: J
authors.lastname: Gao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P.R. China.
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Sun
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D008516:Medicine, Chinese Traditional; D011786:Quality Control; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D013607:Tablets
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D013607:Tablets
keywords: Compound Danshen tablets; content determination; multiwavelength fusion fingerprints; on-line antioxidation; traditional Chinese medicine