title: PVA matches human liver in needle-tissue interaction.
abstract: Medical phantoms can be used to study needle-tissue interaction and to train medical residents. The purpose of this research is to study the suitability of polyvinyl alcohol (PVA) as a liver tissue mimicking material in terms of needle-tissue interaction. Insertions into ex-vivo human livers were used for reference. Six PVA samples were created by varying the mass percentage of PVA to water (4m% and 7m%) and the number of freeze-thaw cycles (1, 2 and 3 cycles, 16hours of freezing at -19°C, 8hours of thawing). The inner needle of an 18 Gauge trocar needle with triangular tip was inserted 13 times into each of the samples, using an insertion velocity of 5 mm/s. In addition, 39 insertions were performed in two ex-vivo human livers. Axial forces on the needle were captured during insertion and retraction and characterized by friction along the needle shaft, peak forces, and number of peak forces per unit length. The concentration of PVA and the number of freeze-thaw cycles both influenced the mechanical interaction between needle and specimen. Insertions into 4m% PVA phantoms with 2 freeze-thaw cycles were comparable to human liver in terms of estimated friction along the needle shaft and the number of peak forces. Therefore, these phantoms are considered to be suitable liver mimicking materials for image-guided needle interventions. The mechanical properties of PVA hydrogels can be influenced in a controlled manner by varying the concentration of PVA and the number of freeze-thaw cycles, to mimic liver tissue characteristics.
authors.affiliation: BioMechanical Engineering Department, Delft University of Technology, 2628 CD Delft, The Netherlands. Electronic address: T.L.deJong@tudelft.nl.
authors.forename: Tonke L
authors.initials: TL
authors.lastname: de Jong
authors.affiliation: BioMechanical Engineering Department, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: Loes H
authors.initials: LH
authors.lastname: Pluymen
authors.affiliation: BioMechanical Engineering Department, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: van Gerwen
authors.affiliation: Neurosciences Department, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands.
authors.forename: Gert-Jan
authors.initials: GJ
authors.lastname: Kleinrensink
authors.affiliation: BioMechanical Engineering Department, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: Jenny
authors.initials: J
authors.lastname: Dankelman
authors.affiliation: BioMechanical Engineering Department, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: John J
authors.initials: JJ
authors.lastname: van den Dobbelsteen
mesh_terms: D059985:Cryogels; D005615:Freezing; D006801:Humans; D008099:Liver / Q000601:surgery*; D009339:Needles; D019047:Phantoms, Imaging; D011142:Polyvinyl Alcohol
chemical_list: D059985:Cryogels; D011142:Polyvinyl Alcohol
keywords: Medical phantoms; Needle-tissue interaction; Polyvinyl alcohol (PVA) hydrogel; Radiologic liver interventions; Tissue mimicking material