title: Paradigms for single-patient multimodality treatment for cerebral aneurysms: single-center eleven-year experience.
abstract: Endovascular and surgical techniques are conventional options for treating intracranial aneurysms, but criteria for selecting an optimal approach for individual patients remain variable across practitioners and institutions. While endovascular and surgical approaches are generally used alone, both modalities combined in single patients can produce efficacious outcomes. The aim of this study was to evaluate outcomes of combined, concomitant endovascular and surgical modalities in the treatment of multiple and/or complex aneurysms in single patients. Indications, sequencing rationale, and categorization for multimodality treatments are reviewed. All intracranial aneurysms treated at our institution from 2004 to 2014 were reviewed. Single patients who had undergone concomitant endovascular and surgical treatments were eligible for participation in our study. Demographic data and clinical presentation parameters, including location, size, and morphological features of lesions, treatment sequencing, and outcomes were recorded. Our cohort consisted of 27 patients with 57 aneurysms who received concomitant endovascular and surgical treatment of their aneurysm(s). One patient arrived to us after he had an aneurysm clipped at an outside institution and then required treatment for a contralateral ruptured aneurysm. 66.7% of patients were diagnosed with subarachnoid hemorrhage. These were subdivided according to therapeutic approach: clipping and coiling (CL+CO), clipping and stenting (CL+ST), bypass and endovascular parent vessel occlusion (PVO) (BY+PVO), attempted clipping then stenting, and bypass followed by stenting. Glasgow Outcome Scale was as follows: CL-CO-Multiple, 4.17 (five in unruptured patients, 3.75 in ruptured); CO-CL-Multiple, five (all patients had a ruptured aneurysm); CL-CO-Single, three (all patients had a ruptured aneurysm); CO-CL-Single, five (all patients had a ruptured aneurysm). No patients suffered a new neurological deficit as a result of treatment. A total of two mortalities were documented. Concomitant, mutimodality endovascular and surgical therapy may offer a safe and potentially more effective paradigm than single modality approaches for the management of multiple, complex, or "failed" aneurysm treatments in selected patients.
authors.affiliation: Department of Neurosurgery, Hofstra Northwell School of Medicine, and Northwell Health, 300 Community Drive, 9 Tower, Manhasset, NY, USA.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alobaid
authors.affiliation: Division of Neurosurgery, Maimonides Medical Center, Brooklyn, NY, USA.
authors.forename: Erez
authors.initials: E
authors.lastname: Nossek
authors.affiliation: Department of Neurosurgery, Hofstra Northwell School of Medicine, and Northwell Health, 300 Community Drive, 9 Tower, Manhasset, NY, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Wagner
authors.affiliation: Department of Neurosurgery, Hofstra Northwell School of Medicine, and Northwell Health, 300 Community Drive, 9 Tower, Manhasset, NY, USA.
authors.forename: Avi
authors.initials: A
authors.lastname: Setton
authors.affiliation: Department of Neurosurgery, Hofstra Northwell School of Medicine, and Northwell Health, 300 Community Drive, 9 Tower, Manhasset, NY, USA.
authors.forename: Amir R
authors.initials: AR
authors.lastname: Dehdashti
authors.affiliation: Department of Neurosurgery, Hofstra Northwell School of Medicine, and Northwell Health, Lenox-Hill Hospital, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Langer
authors.affiliation: Department of Neurosurgery, Hofstra Northwell School of Medicine, and Northwell Health, 300 Community Drive, 9 Tower, Manhasset, NY, USA. dchalif@nshs.edu.
authors.forename: David
authors.initials: D
authors.lastname: Chalif
mesh_terms: D000328:Adult; D000368:Aged; D002340:Carotid Artery Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D002533:Cerebral Angiography; D015331:Cohort Studies; D003131:Combined Modality Therapy / Q000379:methods*; D057510:Endovascular Procedures; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D009886:Ophthalmoplegia / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D015607:Stents; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Aneurysm; Brain; Bypass; Clipping; Coiling; Endovascular: microsurgery; Subarachnoid hemorrhage