title: Chin Symphysis Bone, Allograft, and Platelet-Rich Fibrin: Is the Combination Effective in Repair of Alveolar Cleft?
abstract: OBJECTIVE
  Secondary grafting of alveolar defects with iliac crest bone is a common treatment method in cleft patients. The aim of this study was to evaluate the effectiveness of the combination of symphysis bone, allograft, and platelet-rich fibrin in regeneration of alveolar defects compared with iliac bone graft.
  
  
  METHODS
  In this randomized clinical trial, patients with unilateral alveolar defects were divided randomly into two categories. Group A comprised patients in whom the combination of chin symphysis bone plus allogeneic bone material plus leukocyte- and platelet-rich fibrin was considered for treatment. Group B comprised patients in whom iliac bone graft was considered. Cone beam computed tomography before treatment and 1 year postoperatively was used for measurement of bone formation (bone volume in cubic centimeters). The data were analyzed by paired t and χ2tests via SPSS software (version 23; IBM, Armonk, NY). P < .05 was considered significant.
  
  
  RESULTS
  Each group included 10 patients (with 6 male patients in group A and 5 male patients in group B). The mean age of patients in groups A and B was 9.5 ± 1.5 years and 9.9 ± 1.9 years, respectively. The mean volume of alveolar defects was 0.89 ± 0.29 cm3in group A and 0.95 ± 0.27 cm3in group B. The percentage of bone regeneration in groups A and B was 69.5% and 73.8%, respectively.
  
  
  CONCLUSIONS
  It seems that chin symphysis bone plus allogeneic bone material plus platelet-rich fibrin is a proper combination for bone regeneration in alveolar defects with a small to moderate volume range.
authors.affiliation: Associated Professor, Torabinejad Dental Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Bijan
authors.initials: B
authors.lastname: Movahedian Attar
authors.affiliation: Postgraduate Student of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: 3n.navid.naghdi@gmail.com.
authors.forename: Navid
authors.initials: N
authors.lastname: Naghdi
authors.affiliation: Assistant professor, Dental Implants Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Milad
authors.initials: M
authors.lastname: Etemadi Sh
authors.affiliation: Associate Professor, Torabinejad Dental Research Center, Department of Oral and Maxillofacial Radiology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mojdeh
authors.initials: M
authors.lastname: Mehdizadeh
mesh_terms: D000293:Adolescent; D064591:Allografts; D000539:Alveolar Process / Q000002:abnormalities* / Q000601:surgery*; D001792:Blood Platelets; D001861:Bone Regeneration; D016025:Bone Transplantation; D002648:Child; D002680:Chin / Q000601:surgery*; D003131:Combined Modality Therapy; D000013:Congenital Abnormalities / Q000628:therapy; D005260:Female; D005337:Fibrin / Q000008:administration & dosage*; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D008297:Male; D016896:Treatment Outcome
chemical_list: D005337:Fibrin