title: The effects of 6-Gingerol on reproductive improvement, liver functioning and Cyclooxygenase-2 gene expression in estradiol valerate - Induced polycystic ovary syndrome in Wistar rats.
abstract: 6-Gingerol is the major pungent ingredient of ginger with anti-inflammatory and antioxidant properties. In this study, we evaluate the effects of 6-gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats. Thirty six female Wistar rats were divided into 4 groups: control, received normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6-gingerol (200 μg/kgand 400 μg/kg) for 14 days. The administration of EV led to increase body and ovarian weights, abnormality in serum sex steroid profile, decrease in antioxidant activity and increase in COX-2 gene expression. 6-gingerol treatments, particularly the 400 μg/kgdose, markedly attenuated these alterations. 6-gingerol showed beneficial effects in the EV induced PCOS rats via decreased expression of COX-2, restored biochemical parameters to normal and decreased of cysts in the ovaries.
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Parisa Sadat
authors.initials: PS
authors.lastname: Pournaderi
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: parichehrehyaghmaei@gmail.com.
authors.forename: Parichehreh
authors.initials: P
authors.lastname: Yaghmaei
authors.affiliation: Department of Animal Sciences, Islamic Azad University, Golpayegan Branch, Isfahan, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Khodaei
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Noormohammadi
authors.affiliation: Skin Disease and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Seyed Hossein
authors.initials: SH
authors.lastname: Hejazi
mesh_terms: D000818:Animals; D002396:Catechols / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000633:toxicity; D005233:Fatty Alcohols / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*
chemical_list: D002396:Catechols; D005233:Fatty Alcohols; D004958:Estradiol; C007845:gingerol; D051546:Cyclooxygenase 2
keywords: 6-Gingerol; COX-2; Estradiol valerate; PCOS; Rat