title: Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells.
abstract: Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
authors.affiliation: Korea Institute of Science and Technology (KIST), Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Seoul 136-791, South Korea. yunkyungkim@kist.re.kr.
authors.forename: Sungsu
authors.initials: S
authors.lastname: Lim
authors.forename: Md Mamunul
authors.initials: MM
authors.lastname: Haque
authors.forename: Dongdong
authors.initials: D
authors.lastname: Su
authors.forename: Dohee
authors.initials: D
authors.lastname: Kim
authors.forename: Jun-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000032:analysis* / Q000737:chemistry; D002460:Cell Line; D004195:Disease Models, Animal; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D015394:Molecular Structure; D009474:Neurons / Q000378:metabolism* / Q000473:pathology*; D061848:Optical Imaging; D066329:Protein Aggregates; D016875:tau Proteins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D066329:Protein Aggregates; D016875:tau Proteins