title: Acute effects of a beverage containing bitter melon extract (CARELA) on postprandial glycemia among prediabetic adults.
abstract: Acute ingestion of bitter melon (BM) has been shown to suppress the postprandial glycemic response in diabetics, but its impact on glucose regulation among individuals with impaired glucose tolerance is unclear. Moreover, one's glucose tolerance level may influence the effectiveness of BM. This study aimed to examine the acute effects of a beverage containing BM extract on blood glucose regulation during an oral glucose tolerance test (OGTT) among prediabetics.
  
  
  
  Ten prediabetic adults completed two OGTTs-glucose only (D2) and glucose+BM (D3). Responders were identified as subjects whose area under the glucose curve (AUCglu) during D3 was lower than D2. To compare the acute effects of the beverage among individuals with varying glucose tolerance levels, subjects were grouped by their glucose response pattern-Fastpeak(peak glucose (Glupeak) at 30 min postglucose (30P)) and Slowpeak(Glupeakafter 30P).
  
  
  
  During D3, responders (n=5) experienced a 13.2% reduction in AUCglu(95% confidence interval (CI): -18.1% to -8.3%), 12.2% reduction in mean glucose (95% CI: -17.3% to -7.0%) and 10.6% reduction in Glupeak(95% CI: -17.5% to -3.7%); plasma glucose was reduced by 9.1% at 30P (95% CI: -15.6% to -2.6%), -24.0% at 60P (95% CI: -36.8% to -11.2%) and -20.0% at 90P (95% CI: -35.8% to -4.2%) during D3. No between-trial differences were noted for Fastpeakor Slowpeak.
  
  
  
  Acute ingestion of BM prior to the second OGTT (D3) led to a reduced postprandial glucose response in 50% of the subjects but did not affect the insulin response. Furthermore, the effectiveness of the beverage was seemingly uninfluenced by the subjects' glucose tolerance level. Although BM has shown to aid blood glucose management in diabetics, it remains uncertain why only a portion of subjects responded positively to the BM extract in the current study.
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Boone
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Stout
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Gordon
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Redd
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Church
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.|Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, FL, USA.
authors.forename: L P
authors.initials: LP
authors.lastname: Oliveira
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Fukuda
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Hoffman
mesh_terms: D000368:Aged; D001628:Beverages; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029777:Momordica charantia; D010936:Plant Extracts / Q000008:administration & dosage*; D019518:Postprandial Period / Q000187:drug effects* / Q000502:physiology; D011236:Prediabetic State / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts