title: Long non-coding RNAs: a rising biotarget in colorectal cancer.
abstract: Colorectal cancer (CRC) is a common gastrointestinal cancer, with a high incidence and high mortality. Long non-coding RNAs (lncRNAs) are involved in the development, invasion and metastasis, early diagnosis, prognosis, the chemoresistance and radioresistance of CRC through interference with mRNA activity, directly combining with proteins to regulate their activity or alter their localization, influencing downstream gene expression by inhibiting RNA polymerase and regulating gene expression as competing endogenous RNAs. Recent progress in next generation sequencing and transcriptome analysis has revealed that tissue and cancer-type specific lncRNAs could be useful prognostic markers. Here, the CRC-associated lncRNAs from recent studies until October 2016 are reviewed and multiple studies that have confirmed CRC-associated lncRNAs are summarized. This review may be helpful in understanding the overall relationships between the lncRNAs involved in CRC.
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Qu
authors.affiliation: Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha, P. R. China.
authors.forename: Dong-Kai
authors.initials: DK
authors.lastname: Wu
authors.affiliation: Department of Pathology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P. R. China.
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Lu
authors.affiliation: Department of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, P. R. China.
authors.forename: Yue-Sheng
authors.initials: YS
authors.lastname: Sun
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Qu
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: colorectal cancer; epithelial-mesenchymal transition; invasion; long non-coding RNAs