title: Lactols in an asymmetric aldol-desymmetrization sequence: access to tetrahydro-4H-furo[2,3-b]pyran-2-one and tetrahydro-4H-furo[2,3-b]furan-2-one derivatives.
abstract: An asymmetric aldol-desymmetrization sequence was developed which provided highly efficient access to important bicyclic oxygen-containing scaffolds with multiple chiral centers and one is a quaternary stereogenic center containing a free hydroxy group. Moreover, starting from racemic precursors, the final products were obtained as two separable diastereomers by flash chromatography. Several other heterocycles could also be easily generated with this strategy.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, and Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, People's Republic of China.
authors.forename: Ji-Yao
authors.initials: JY
authors.lastname: Li
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, People's Republic of China. liuyankai@ouc.edu.cn.
authors.forename: Ke-Wei
authors.initials: KW
authors.lastname: Yu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, and Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, People's Republic of China.
authors.forename: Chao-Chao
authors.initials: CC
authors.lastname: Xie
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, People's Republic of China. liuyankai@ouc.edu.cn.
authors.forename: Yan-Kai
authors.identifier: http://orcid.org/0000-0002-6559-2348
authors.initials: YK
authors.lastname: Liu