title: Renoprotective Effects of Shout Camphor Medicinal Mushroom (Taiwanofungus camphorates, Basidiomycetes) Mycelia on Several Media in Mice with Chronic Kidney Disease.
abstract: Taiwanofungus camphoratus has been widely used in Taiwan as a folk medicine to prevent and treat liver diseases, diarrhea, abdominal pain, itchy skin, and hypertension. Recent studies have shown that T. camphoratus mycelia extracts exert anti-inflammatory and antioxidant effects on some types of renal disease, but the effect of T. camphoratus mycelia on chronic kidney disease (CKD) remains unclear. In this study we used the Bioresource Collection and Research Center (BCRC) medium and modified media (e.g., BCRC+A, HKS1, and HKS1+A media) to incubate T. camphorates mycelia and detect the feasible benefits of renal protection in mice with CKD. Five groups of mice with a partial nephrectomy (each mouse weighed approximately 30 g) received a daily administration of different media-treated T. camphoratus mycelia water solutions (3 mg dried mycelia dissolved in 0.3 mL water) by oral gavage for 30 days, while a control group received distilled water. The results show that progressive increased blood urea nitrogen and serum creatinine were significantly inhibited in the HKS1+A group on days 10 and 30. Plasma total protein was effectively increased in the HKS1 and HKS1+A groups. The BCRC and BCRC+A groups exhibited no obvious improvement in renal function. The results suggest that the HKS1+A medium provides the optimal effect in preventing the deterioration of kidney function and might have a renoprotective effect on CKD.
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Shu-Chi
authors.initials: SC
authors.lastname: Wang
authors.affiliation: Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Chih-Hui
authors.initials: CH
authors.lastname: Yang
authors.affiliation: Research Institute of the University of Bucharest, Life, Environmental and Earth Sciences, Bucharest, Romania.
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Lin
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Keng-Shiang
authors.initials: KS
authors.lastname: Huang
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Wang
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Su
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Cing-Yan
authors.initials: CY
authors.lastname: Jhang
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chung
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Jiun-Hua
authors.initials: JH
authors.lastname: Chou
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001691:Biological Therapy / Q000379:methods*; D055453:Coriolaceae; D003404:Creatinine / Q000097:blood; D004032:Diet / Q000379:methods*; D004195:Disease Models, Animal; D008297:Male; D008813:Mice, Inbred ICR; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D016896:Treatment Outcome; D014508:Urea / Q000097:blood
chemical_list: D014508:Urea; D003404:Creatinine