title: Correlations between theMEG-A3gene and incidence of breast cancer.
abstract: The aim of the present study was to examine the interrelations betweenMEG-A3gene and incidence of breast cancer. The expression ofMEG-A3gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same patient was measured at different time-points (1, 3, 6, 8, 12 and 24 months), and the protein expression levels were determined using western blotting. The results showed that, the mRNA level inMEG-A3gene of samples of patients with breast cancer was significantly higher than that of normal women (p<0.05). TheMEG-A3gene expression increased apparently with the prolongation and aggravation of the disease. In conclusion, there is a close correlation betweenMEG-A3gene and the incidence of breast cancer; thus,MEG-A3gene contributes to the occurrence and deterioration of breast cancer to some extent. It provides a theoretical basis for later disease treatment.
authors.affiliation: Department of Thyroid and Breast Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Thyroid and Breast Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Guo
authors.affiliation: Department of Thyroid and Breast Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Sun
keywords: MED-A3 gene; RT-PCR; breast cancer; interrelation; western blotting