title: In vivo response of AZ31 alloy as biliary stents: a 6 months evaluation in rabbits.
abstract: Mg-based metallic materials have been making continuing progress as vascular stents. However, the research of Mg-based materials as non-vascular stents is still at its primary stage. AZ31 stents hereby were implanted into the common bile duct of rabbits for 6 months. The results revealed an existence of 93.82 ± 1.36% and 30.89 ± 2.46% of the original volume after 1 and 3 month, respectively. Whole blood tests indicated an inflammation decreasing to normal level after 3 month implantation. A benign host response was observed via H&E staining. Nonuniform corrosion at the two ends of the stents was observed and considered the results of flow or local inflammation. Moreover, the application of Mg-based materials for different stenting treatment were reviewed and compared. Esophagus was hypothesized most destructive, whilst blood vessel and bile duct considered similar and less destructive. Trachea and nasal cavity were thought to be mildest.
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Shengmin
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Huahu
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
authors.forename: Jirun
authors.initials: J
authors.lastname: Peng
mesh_terms: D000497:Alloys / Q000633:toxicity*; D000818:Animals; D001662:Biliary Tract Surgical Procedures / Q000379:methods; D001774:Blood Chemical Analysis; D003135:Common Bile Duct / Q000473:pathology*; D006651:Histocytochemistry; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D011817:Rabbits; D015607:Stents / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000497:Alloys; C586533:Mg-Al-Zn-Mn-Si-Cu alloy