title: Age-adjusted Charlson comorbidity index as a prognostic factor of hypopharyngeal cancer treated with chemoradiation therapy.
abstract: CONCLUSIONS
  The age-adjusted Charlson comorbidity index (ACCI) was associated with overall survival, disease-specific survival, and non-cancer death in patients treated with chemoradiation therapy (CRT) for hypopharyngeal cancer (HPC). Further studies using other CRT regimens are required.
  
  
  OBJECTIVE
  To investigate the impact of the ACCI on survival in patients with HPC.
  
  
  METHODS
  This study reviewed 128 patients with HPC who received CRT between 2004-2012. The survival rates and the cumulative incidence of non-cancer death according to the ACCI were estimated. A Cox proportional hazard model was used to assess the hazard ratio (HR) of the ACCI.
  
  
  RESULTS
  The disease-specific survival rates at 3 years for the low ACCI group, moderate group, and high group were 80.1%, 45.8%, and 54.8%, respectively (p = 0.007). The laryngectomy-free survival rates at 3 years were 61%, 39.7%, and 37.1%, respectively (p = 0.137). The cumulative incidences of non-HPC death were 5% for the low/moderate ACCI group and 15.5% for the high ACCI group (p = 0.031). The HRs compared to the low ACCI group for overall survival, disease-specific survival, and laryngectomy-free survival were 2.61 and 2.74, 2.55 and 2.27, and 1.75 and 1.97 in the moderate and high ACCI groups, respectively.
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Takenaka
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakahara
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Atshushi
authors.initials: A
authors.lastname: Hanamoto
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Fukusumi
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Michiba
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Takemoto
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Cho
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Inohara
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D002423:Cause of Death; D015897:Comorbidity; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
keywords: Hypopharynx; chemotherapy; head and neck; radiation; squamous cell cancer