title: Organobase-catalyzed [1,2]-Brook rearrangement of silyl glyoxylates.
abstract: A highly efficient [1,2]-Brook rearrangement of silyl glyoxylates has been developed using DBU as the organobase-catalyst. This [1,2]-Brook rearrangement is applicable to a number of thiols and secondary phosphine oxides containing acidic protons. These nucleophiles afford the corresponding Brook products in high yields. Using this methodology, a formal synthesis of anti-HIV drug compound lamivudine was realized.
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China. hanmy10@126.com.
authors.forename: Man-Yi
authors.identifier: http://orcid.org/0000-0001-7448-8924
authors.initials: MY
authors.lastname: Han
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China. hanmy10@126.com.
authors.forename: Fei-Yan
authors.initials: FY
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China. hanmy10@126.com.
authors.forename: Di
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Faculty for Materials and Energy, Southwest University, Chongqing 400715, P.R. China.
authors.forename: Zhigang
authors.identifier: http://orcid.org/0000-0003-1805-5061
authors.initials: Z
authors.lastname: Xu