title: Nuclear reprogramming of cancer stem cells: Corrupting the epigenetic code of cell identity with oncometabolites.
abstract: Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epigenetic codes that govern cell identity. We recently identified how archetypal oncometabolites, without altering the baseline expression of endogenous stem cell maintenance genes but endowing cells with epigenetic states refractory to differentiation, considerably enhance the global kinetic efficiency of nuclear reprogramming processes that generate CSC-like statesde novo. This study highlights that metabolo-epigenetic axes of communication can direct the development and maintenance of CSCs during the natural history of cancer diseases.
authors.affiliation: ProCURE (Program Against Cancer Therapeutic Resistance), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Catalonia, Spain; Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Salt, Catalonia, Spain.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Menendez
authors.affiliation: Computational & Mathematical Biology Research Group, Center de Recerca Matemàtica, Barcelona, Catalonia, Spain; ICREA (Institució Catalana d'Estudis i Recerca Avançats), Barcelona, Spain; Departament de Matemàtiques, Universitat Autónoma de Barcelona, Barcelona, Spain; Barcelona Graduate School of Mathematics (BGSMath), Barcelona, Spain.
authors.forename: Tomás
authors.initials: T
authors.lastname: Alarcón
keywords: Cancer stem cells; epigenetics; nuclear reprogramming; oncometabolites