title: Association of biochemical markers with the severity of pre-eclampsia.
abstract: OBJECTIVE
  To assess the association between pre-eclampsia severity and biochemical and ultrasonography markers.
  
  
  METHODS
  A retrospective study was undertaken of women with severe pre-eclampsia (group 1, n=90), mild pre-eclampsia (group 2, n=90), or a normal pregnancy (group 3, n=90) who attended a hospital in Egypt in October 2013-April 2015. Associations between pre-eclampsia and biochemical, cardiotocography, and ultrasonography markers were investigated.
  
  
  RESULTS
  There were significant differences between the groups in C-reactive protein (331.44±112.38, 251.43±59.05, and 23.81±16.19 nmol/L; P≤0.05 for all), platelet count (113.40±36.72, 172.93±57.60, and 212.68±70.00×109/L; P≤0.05 for group 1 comparisons), alanine transaminase (52.24±14.83, 38.34±13.12, and 23.11±6.92 U/L; P≤0.05 for group 1 comparisons), and serum uric acid (600.80±117.19, 481.83±118.97, and 243.89±53.54 μmol/L; P=0.050 for group 3 comparisons). Cardiotocography score was worse among women with severe pre-eclampsia than among those in the other two groups (P=0.039 for both comparisons). Biophysical profile score and umbilical artery resistance index differed by group (P≤0.05 for all). Middle cerebral artery resistance index was lower among women with severe pre-eclampsia (P≤0.05).
  
  
  CONCLUSIONS
  The levels of C-reactive protein, blood urea nitrogen, serum uric acid, and alanine transaminase, and the platelet count were linked with the presence and severity of pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Maged
authors.affiliation: Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.
authors.forename: Gamal
authors.initials: G
authors.lastname: Aid
authors.affiliation: Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.
authors.forename: Nehal
authors.initials: N
authors.lastname: Bassiouny
authors.affiliation: Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.
authors.forename: Doaa S
authors.initials: DS
authors.lastname: Eldin
authors.affiliation: Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.
authors.forename: Sherif
authors.initials: S
authors.lastname: Dahab
authors.affiliation: Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.
authors.forename: Nevein K
authors.initials: NK
authors.lastname: Ghamry
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001806:Blood Urea Nitrogen; D002097:C-Reactive Protein / Q000032:analysis; D004534:Egypt; D005260:Female; D006801:Humans; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014463:Ultrasonography; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein; D000410:Alanine Transaminase
keywords: Biochemical markers; C-reactive protein; Maternal complications; Neonatal complications; Severe pre-eclampsia