title: Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake.
abstract: Extracellular vesicles (EVs), lipid bilayer-enclosed structures that contain a variety of biological molecules shed by cells, are increasingly becoming appreciated as a major form of cell-to-cell communication. Indeed, EVs have been shown to play important roles in several physiological processes, as well as diseases such as cancer. EVs dock on to the surfaces of recipient cells where they transmit signals from the cell surface and/or transfer their contents into cells to elicit functional responses. EV docking and uptake by cells represent critical, but poorly understood processes. Here, we focus on the mechanisms by which EVs dock and transfer their contents to cells. Moreover, we highlight how these findings may provide new avenues for therapeutic intervention.
authors.affiliation: Department of Molecular Medicine, Cornell University, Ithaca, NY 14850, United States.
authors.forename: Kinsley C
authors.initials: KC
authors.lastname: French
authors.affiliation: Department of Molecular Medicine, Cornell University, Ithaca, NY 14850, United States.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Antonyak
authors.affiliation: Department of Molecular Medicine, Cornell University, Ithaca, NY 14850, United States. Electronic address: rac1@cornell.edu.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Cerione
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001692:Biological Transport; D022461:Caveolins / Q000235:genetics / Q000378:metabolism; D002450:Cell Communication; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism; D021962:Membrane Microdomains / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D059470:Tetraspanins / Q000235:genetics / Q000378:metabolism; D059016:Tumor Microenvironment / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D022461:Caveolins; D016326:Extracellular Matrix Proteins; D016023:Integrins; D059470:Tetraspanins
keywords: Cancer; Docking; Exosomes; Extracellular vesicles; Intercellular communication; Metastasis; Microvesicles; Targeting; Uptake