title: Association of a missense mutation in the positional candidate gene glutamate receptor-interacting protein 1 with backfat thickness traits in pigs.
abstract: OBJECTIVE
  Previously, we reported quantitative trait loci (QTLs) affecting backfat thickness (BFT) traits on pig chromosome 5 (SW1482-SW963) in an F2 intercross population between Landrace and Korean native pigs. The aim of this study was to evaluate glutamate receptor-interacting protein 1 (GRIP1) as a positional candidate gene underlying the QTL affecting BFT traits.
  
  
  METHODS
  Genotype and phenotype analyses were performed using the 1,105 F2progeny. A mixed-effect linear model was used to access association between these single nucleotide polymorphism (SNP) markers and the BFT traits in the F2intercross population.
  
  
  RESULTS
  Highly significant associations of two informative SNPs (c.2442 T>C, c.3316 C>G [R1106G]) inGRIP1with BFT traits were detected. In addition, the two SNPs were used to construct haplotypes that were also highly associated with the BFT traits.
  
  
  CONCLUSIONS
  The SNPs and haplotypes of theGRIP1gene determined in this study can contribute to understand the genetic structure of BFT traits in pigs.
authors.affiliation: Korea Zoonosis Research Institute (KoZRI), Chonbuk National University, Iksan 54531, Korea.
authors.forename: Jae-Bong
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Jeju 63242, Korea.
authors.forename: Hee-Bok
authors.initials: HB
authors.lastname: Park
authors.affiliation: Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea.
authors.forename: Chae-Kyoung
authors.initials: CK
authors.lastname: Yoo
authors.affiliation: Division of Applied Life Science (BK21 plus), Gyeongsang National University, Jinju 52828, Korea.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Jeju 63242, Korea.
authors.forename: In-Cheol
authors.initials: IC
authors.lastname: Cho
authors.affiliation: Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea.|Division of Applied Life Science (BK21 plus), Gyeongsang National University, Jinju 52828, Korea.
authors.forename: Hyun-Tae
authors.initials: HT
authors.lastname: Lim
keywords: Backfat; Glutamate Receptor-interacting Protein 1 (GRIP1); Korean Native Pigs; Landrace; Quantitative Trait Loci (QTL)