title: Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance.
abstract: OBJECTIVE
  To study the expression of RUNX3 in colorectal adenocarcinoma tissues and its correlation with microvessel density (MVD), and investigate the clinical pathological prognostic significance of RUNX3 and MVD in patients with colorectal cancer.
  
  
  METHODS
  The expression value of RUNX3 and MVD in 70 specimens' colorectal adenocarcinoma tissues were detected by immunohistochemistry staining technique. The correlation between their expression and the clinicopathologic features was also investigated.
  
  
  RESULTS
  The expression value of RUNX3 and the positive rates of RUNX3 in colorectal adenocarcinoma tissues were 3.25 ± 1.14 and 25.71% (18/70). The expression value of MVD in colorectal adenocarcinoma tissues was 13.14 ± 3.23. Expression of RUNX3 and MVD value were correlated with CEA, serosal invasion, liver metastasis, lymph node metastasis, and TNM stage (P < 0.01). The expression value of RUNX3 had negative correlations with that of MVD.
  
  
  CONCLUSIONS
  The high expression of RUNX3 could inhibit tumor microvascular generation in order to have negative control response on invasion and distant metastasis.
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China. Electronic address: yfyxuejun@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Xue
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Xue-Liang
authors.initials: XL
authors.lastname: Wu
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Huang
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Qu
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Sun
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Zhang
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, HeBei, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Pan
keywords: Clinical significance; Colorectal neoplasms; Microvessel density; RUNX3