title: Affective and cognitive correlates of PTSD: Electrocortical processing of threat and perseverative errors on the WCST in combat-related PTSD.
abstract: PTSD is characterized by both affective and cognitive dysfunction. Affectively, PTSD is associated with both heightened emotional reactivity and disengagement. Cognitively, perseverative thinking is a core feature of the disorder. In order to assess the interactive effects of affective and cognitive correlates of PTSD symptoms, 47 OEF/OIF/OND veterans completed an emotional faces matching task while EEG (i.e., late positive potential; LPP) was recorded, and separately completed the Wisconsin Card Sorting Test (WCST) to assess perseverative errors. There was no relationship between PTSD symptoms and either perseverative errors or EEG reactivity to faces. However, an interaction was found such that high perseverative errors on the WCST and a relatively enhanced LPP to angry faces was associated with greater PTSD symptoms, while low errors on the WCST and a relatively blunted LPP to angry faces also related to greater PTSD symptoms. These findings suggest that emotion-cognition interactions are important for understanding PTSD, and that distinct emotion-cognition constellations interact with symptoms.
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA. Electronic address: jdigangi@psych.uic.edu.
authors.forename: Julia A
authors.initials: JA
authors.lastname: DiGangi
authors.affiliation: Department of Psychiatry, Pennsylvania State University, College of Medicine, 500 University Dr, Hershey, PA 17033, USA.
authors.forename: Autumn
authors.initials: A
authors.lastname: Kujawa
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA; College of Health & Human Services, Governors State University, 1 University Parkway, University Park, IL 60484, USA.
authors.forename: Darrin M
authors.initials: DM
authors.lastname: Aase
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Babione
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Schroth
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Levy
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Kennedy
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA.
authors.forename: Justin E
authors.initials: JE
authors.lastname: Greenstein
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Proescher
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Walters
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA.
authors.forename: Holly
authors.initials: H
authors.lastname: Passi
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Langenecker
authors.affiliation: Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Road, Chicago, IL 60608, USA; Departments of Psychology, Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood St., Chicago, IL 60612, USA.
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005145:Face; D006801:Humans; D054542:Iraq War, 2003-2011; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis* / Q000209:etiology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D013313:Stress Disorders, Post-Traumatic / Q000150:complications*; D014728:Veterans; D055815:Young Adult
keywords: EEG; Executive function; Late positive potential; Neuropsychology; PTSD; Veteran