title: Effects of Deltorphin II and Its Retroenantio Analog on Cardiac Tolerance to Ischemia and Reperfusion.
abstract: Selective agonist of δ2-opioid receptors deltorphin II and its retroenantio analog (0.12 mg/kg intravenously) were preventively injected to male Wistar rats 15 min prior to 45-min coronary occlusion or 5 min before 120-min reperfusion. Administration of deltorphin II before artery occlusion and before reperfusion decreased the infarct size/area at risk ratio. Deltorphin II prevented the appearance of ischemia-provoked ventricular arrhythmias and exerted no effect on HR and BP (systolic and diastolic). The retroenantio analog of deltorphin II produced no antiarrhythmic or infarct-limiting effects, but reduced HR without affecting BP. Deltorphin II can be viewed as a promising prototype for a medicinal remedy to treat acute myocardial infarction.
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Mukhomedzyanov
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia. maslov@cardio-tomsk.ru.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.affiliation: Peptide Synthesis Company, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ovchinnikov
authors.affiliation: Peptide Synthesis Company, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Sidorova
authors.affiliation: Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors.forename: J M
authors.initials: JM
authors.lastname: Pei
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Tsibul'nikov
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Tsepokina
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Khutornaya
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kutikhin
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002561:Cerebrovascular Disorders; D003331:Coronary Vessels / Q000601:surgery; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000701:Analgesics, Opioid; D002316:Cardiotonic Agents; D009842:Oligopeptides; D017465:Receptors, Opioid, delta; C060209:deltorphin II, Ala(2)-
keywords: heart; ischemia; opioid peptides; reperfusion