title: [Etoposide and Carboplatin Effective for Treatment of Small Cell Carcinoma of Prostate : A Report of Two Cases].
abstract: Case 1 : A 76-year-old man consulted a physician because of pollakisuria, decline of urinary stream. A high level of serum prostate specific antigen (PSA) was detected and he came to our hospital. He was diagnosed to have prostate cancer, cT3aN0M1b, and was treated with combined androgen blockage (CAB). Two years and nine months later, postrenal failure appeared and serum level of neuron-specific enolase (NSE) was 162 ng/ml. We performed re-biopsy of prostate, and pathological examination indicated small cell carcinoma of the prostate. We treated him with combination chemotherapy comprised of etoposide and carboplatin, which was effective. Serum level of NSE was decreased and computed tomography showed reduction of the prostate volume and metastasis. Case 2 : An 84-year-old man was treated at a hospital with radiation therapy and CAB, because of prostate cancer. He came to our hospital with bladder tamponade. We performed transurethral coagulation and transurethral biopsy. Pathologically it proved to be small cell carcinoma of the prostate. The stage was cT4N1M1a, NSE and pro-gastrin-releasing peptide (Pro-GRP) levels were high. The same treatment given to him as in case 1, effectively decreased the metastasis and the level of serum NSE.
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Satoru
authors.initials: S
authors.lastname: Yumiba
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Asakura
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Okada
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Mototaka
authors.initials: M
authors.lastname: Satoh
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Mikio
authors.initials: M
authors.lastname: Nin
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Masao
authors.initials: M
authors.lastname: Tsujihata
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D005047:Etoposide; D016190:Carboplatin