title: [18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.
abstract: The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease-modifying therapies. Here, we demonstrate that binding of the tau radioligand [18F]AV-1451 was significantly abnormal in both magnitude and distribution in a patient with familial frontotemporal dementia due to a MAPT 10 + 16C>T gene mutation, recapitulating the pattern of neuropathology seen in her father. Given the genetic diagnosis and the non-Alzheimer's pathology, these findings suggest that [18F]AV-1451 might be a useful biomarker in primary tauopathies. Largerscale in vivo andpost-mortemstudies will be needed to assess the technique's specificity.
authors.affiliation: Department of Psychiatry University of Cambridge Cambridge UK.
authors.forename: W Richard
authors.initials: WR
authors.lastname: Bevan Jones
authors.affiliation: Department of Clinical Neurosciences University of Cambridge Cambridge UK.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Cope
authors.affiliation: Department of Psychiatry University of Cambridge Cambridge UK.
authors.forename: Luca
authors.initials: L
authors.lastname: Passamonti
authors.affiliation: Department of Clinical Neurosciences University of Cambridge Cambridge UK.
authors.forename: Tim D
authors.initials: TD
authors.lastname: Fryer
authors.affiliation: Department of Clinical Neurosciences University of Cambridge Cambridge UK.
authors.forename: Young T
authors.initials: YT
authors.lastname: Hong
authors.affiliation: Wolfson Brain Imaging Centre University of Cambridge Cambridge UK.
authors.forename: Franklin
authors.initials: F
authors.lastname: Aigbirhio
authors.affiliation: Discipline of Pathology University of Sydney Sydney Australia.
authors.forename: Jillian J
authors.initials: JJ
authors.lastname: Kril
authors.affiliation: Discipline of Pathology University of Sydney Sydney Australia.
authors.forename: Shelley L
authors.initials: SL
authors.lastname: Forrest
authors.affiliation: Department of Neuropathology Addenbrooke's Hospital Cambridge UK.
authors.forename: Kieren
authors.initials: K
authors.lastname: Allinson
authors.affiliation: Wolfson Brain Imaging Centre University of Cambridge Cambridge UK; Division of Anaesthesia, University of Cambridge Cambridge UK.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Coles
authors.affiliation: Department of Clinical Neurosciences University of Cambridge Cambridge UK.
authors.forename: P
authors.initials: P
authors.lastname: Simon Jones
authors.affiliation: Department of Clinical Neurosciences University of Cambridge Cambridge UK.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Spillantini
authors.affiliation: University of New South Wales Sydney Australia.
authors.forename: John R
authors.initials: JR
authors.lastname: Hodges
authors.affiliation: Department of Psychiatry University of Cambridge Cambridge UK.
authors.forename: John T
authors.initials: JT
authors.lastname: O'Brien
authors.affiliation: Department of Clinical Neurosciences University of Cambridge Cambridge UK; Medical Research Council Cognition and Brain Sciences Unit Cambridge UK.
authors.forename: James B
authors.initials: JB
authors.lastname: Rowe