title: Proteome wide identification of iron binding proteins of Xanthomonas translucens pv. undulosa: focus on secretory virulent proteins.
abstract: Xanthomonas translucens pv. undulosa (Xtu) causes Bacterial Leaf Streak disease in the staple food crops such as wheat and barley. The survival strategies of pathogen and host are determined by the complex interactions occurring between the host plants and the pathogenic microbes. Iron binding proteins are important in the plant-microbe interactions as they are indulged in enzyme catalysis, virulence, metabolic and transport activities. In the presented study, we have identified that ~9.8% of Xtu proteome possess iron binding sequence motifs. Further, the analysis of Xtu proteome for secretory iron binding virulent proteins (IBVPs) revealed the fact that iron co-regulate the function of secretory proteins in virulence. We have found 26 secretory IBVPs and observed that these proteins are diverse in their biological functions ranging from transport to antimicrobial resistance, Reactive oxygen species detoxification and carbohydrate catabolism. The inferences may instigate to design the new strategies to combat and control the microbial diseases of staple food crops.
authors.affiliation: Centre for Computational Biology and Bioinformatics, School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh, 176206, India.
authors.forename: Ankita
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Centre for Computational Biology and Bioinformatics, School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh, 176206, India.
authors.forename: Dixit
authors.initials: D
authors.lastname: Sharma
authors.affiliation: Centre for Computational Biology and Bioinformatics, School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh, 176206, India. skverma@cuhimachal.ac.in.
authors.forename: Shailender Kumar
authors.initials: SK
authors.lastname: Verma
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D050260:Carbohydrate Metabolism / Q000235:genetics; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D033862:Iron-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010935:Plant Diseases / Q000235:genetics / Q000382:microbiology; D018515:Plant Leaves / Q000737:chemistry / Q000235:genetics; D020543:Proteome / Q000235:genetics*; D014908:Triticum / Q000382:microbiology; D014974:Xanthomonas / Q000737:chemistry* / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D033862:Iron-Binding Proteins; D020543:Proteome; D007501:Iron
keywords: Iron binding proteins; Secretory iron binding virulent proteins; Ton-B dependent receptors; Xanthomonas translucens pv. undulosa