title: Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study.
abstract: The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Chul-Hyun
authors.initials: CH
authors.lastname: Cho
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Ahn
authors.affiliation: Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Se Joo
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Seoul National University Bundang Hospital, College of Medicine, Seongnam, Republic of Korea.
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Ha
authors.affiliation: Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hong Jin
authors.initials: HJ
authors.lastname: Jeon
authors.affiliation: Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.
authors.forename: Boseok
authors.initials: B
authors.lastname: Cha
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Busan, Republic of Korea.
authors.forename: Eunsoo
authors.initials: E
authors.lastname: Moon
authors.affiliation: Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
authors.forename: Dong Yeon
authors.initials: DY
authors.lastname: Park
authors.affiliation: Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Psychiatry, Chonnam National University College of Medicine, Gwangju, Republic of Korea.
authors.forename: Hee-Ju
authors.initials: HJ
authors.lastname: Kang
authors.affiliation: Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
authors.forename: Vin
authors.initials: V
authors.lastname: Ryu
authors.affiliation: Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hyonggin
authors.initials: H
authors.lastname: An
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
keywords: Bipolar disorder; Cohort study; Early mood disorders; MDCRC; Major depressive disorder