title: AAZTA: An Ideal Chelating Agent for the Development of44Sc PET Imaging Agents.
abstract: Unprecedented fast and efficient complexation of ScIIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the44Sc(AAZTA)-chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
authors.affiliation: Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.|University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Nagy
authors.affiliation: Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.|University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
authors.forename: Dezső
authors.initials: D
authors.lastname: Szikra
authors.affiliation: Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.|University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Trencsényi
authors.affiliation: University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
authors.forename: Anikó
authors.initials: A
authors.lastname: Fekete
authors.affiliation: Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Garai
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, 28100, Novara, Italy.
authors.forename: Arianna M
authors.initials: AM
authors.lastname: Giani
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, 28100, Novara, Italy.
authors.forename: Roberto
authors.identifier: 0000-0002-6792-8992
authors.initials: R
authors.lastname: Negri
authors.affiliation: Dipartimento di Scienza e Alta Tecnologia and To.Sca.Lab, Università degli Studi dell'Insubria, via Valleggio 11, 22100, Como, Italy.
authors.forename: Norberto
authors.identifier: 0000-0001-9921-2350
authors.initials: N
authors.lastname: Masciocchi
authors.affiliation: Bracco Imaging spa, Bracco Research Centre, Via Ribes 5, 10010, Colleretto Giacosa (TO), Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Maiocchi
authors.affiliation: Bracco Imaging spa, Bracco Research Centre, Via Ribes 5, 10010, Colleretto Giacosa (TO), Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Uggeri
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Debrecen, 4032, Debrecen, Egyetem tér 1, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Tóth
authors.affiliation: Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Centro di Imaging Molecolare e Preclinico, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
authors.affiliation: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, 28100, Novara, Italy.|CAGE Chemicals srl, Via Bovio 6, 28100, Novara, Italy.
authors.forename: Giovanni B
authors.identifier: 0000-0001-7117-0347
authors.initials: GB
authors.lastname: Giovenzana
authors.affiliation: Bracco Imaging spa, Bracco Research Centre, Via Ribes 5, 10010, Colleretto Giacosa (TO), Italy.|Department of Inorganic and Analytical Chemistry, University of Debrecen, 4032, Debrecen, Egyetem tér 1, Hungary.
authors.forename: Zsolt
authors.identifier: 0000-0001-6844-7974
authors.initials: Z
authors.lastname: Baranyai
keywords: PET; kinetics; radiopharmaceuticals; scandium; thermodynamics