title: Formation of diverse polycyclic spirooxindoles via three-component reaction of isoquinolinium salts, isatins and malononitrile.
abstract: The triethylamine promoted three-component reaction of N-(4-nitrobenzyl), N-ethoxycarbonylmethylisoquinolinium bromide, isatins and malononitrile in ethanol afforded spiro[indoline-3,2'-pyrrolo[2,1-a]isoquinolines] in good yields and with high diastereoselectivity. The similar reaction of N-cyanomethylisoquinolinium chloride mainly gave complex indolo[2″,3″:2',3']pyrrolo[3',4':4,5]pyrrolo[2,1-a]isoquinoline derivatives. However, the three-component reaction of N-cyanomethylisoquinolinium chloride, isatins and ethyl cyanoacetate mainly resulted in functionalized spiro[indoline-3,8'-pyrido[2',3':4,5]pyrrolo[2,1-a]isoquinolines].
authors.affiliation: College of Chemistry &Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: College of Chemistry &Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Shen
authors.affiliation: College of Chemistry &Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: College of Chemistry &Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan