title: Nitrogen Oxide, Endothelin-1, and Serotonin in the Blood of Immature Spontaneously Hypertensive Rats.
abstract: Endothelial function is an early and sensitive marker of subclinical increase of BP in children and adolescents. It is associated with an imbalance of the key vasoactive factors (NO, endothelin-1, and serotonin). Immature spontaneously hypertensive rats (SHR line) are characterized by increased plasma concentrations of NO and endothelin-1 (by 14.7% and 2.9 times, respectively) and increased serotonin content in the plasma and platelets (by 2.7 and 2.3 times, respectively) in comparison with Wistar-Kyoto rats. Platelet count in the blood of SHR rats is by 50% higher than in Wistar-Kyoto rats.
authors.affiliation: Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
authors.forename: M D
authors.initials: MD
authors.lastname: Chibireva
authors.affiliation: Kazan State Medical Academy, Ministry of Health of the Russian Federation, Kazan, Tatarstan Republic, Russia.
authors.forename: G N
authors.initials: GN
authors.lastname: Aflyatumova
authors.affiliation: Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Matveeva
authors.affiliation: Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
authors.forename: D F
authors.initials: DF
authors.lastname: Bilalova
authors.affiliation: Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Kuz'mina
authors.affiliation: Kazan State Medical Academy, Ministry of Health of the Russian Federation, Kazan, Tatarstan Republic, Russia.
authors.forename: D I
authors.initials: DI
authors.lastname: Sadykova
authors.affiliation: Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia. razinar@mail.ru.
authors.forename: R R
authors.initials: RR
authors.lastname: Nigmatullina
mesh_terms: D000367:Age Factors; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology; D001794:Blood Pressure; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D010976:Platelet Count; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012701:Serotonin / Q000097:blood*
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide; D012701:Serotonin
keywords: blood; endothelin-1; immature spontaneously hypertensive rats; nitrogen oxide; serotonin