title: BDNF regains function in hippocampal long-term potentiation deficits caused by diencephalic damage.
abstract: Thiamine deficiency (TD), commonly associated with chronic alcoholism, leads to diencephalic damage, hippocampal dysfunction, and spatial learning and memory deficits. We show a decrease in the magnitude of long-term potentiation (LTP) and paired-pulse facilitation (PPF) at CA3-CA1 synapses, independent of sex, following diencephalic damage induced by TD in rats. Thus, despite a lack of extensive hippocampal cell loss, diencephalic brain damage down-regulates plastic processes within the hippocampus, likely contributing to impaired hippocampal-dependent behaviors. However, both measures of hippocampal plasticity (LTP, PPF) were restored with brain-derived neurotrophic factor (BDNF), revealing an avenue for neural and behavioral recovery following diencephalic damage.
authors.affiliation: Department of Psychology, Behavioral Neuroscience Program, Binghamton University, State University of New York, Binghamton, New York 13902, USA.
authors.forename: Lindsey C
authors.initials: LC
authors.lastname: Vedder
authors.affiliation: Department of Psychology, Behavioral Neuroscience Program, Binghamton University, State University of New York, Binghamton, New York 13902, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Savage
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000633:toxicity; D001930:Brain Injuries / Q000209:etiology*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism / Q000627:therapeutic use*; D004027:Diencephalon / Q000473:pathology*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D011745:Pyrithiamine / Q000633:toxicity; D051381:Rats; D013832:Thiamine Deficiency / Q000139:chemically induced / Q000150:complications* / Q000473:pathology
chemical_list: D000963:Antimetabolites; D019208:Brain-Derived Neurotrophic Factor; D011745:Pyrithiamine