title: Multifunctional Conjugated Polymer Nanoparticles for Image-Guided Photodynamic and Photothermal Therapy.
abstract: A multifunctional theranostic platform based on conjugated polymer nanoparticles (CPNs) with tumor targeting, fluorescence detection, photodynamic therapy (PDT), and photothermal therapy (PTT) is developed for effective cancer imaging and therapy. Two conjugated polymers, poly[9,9-bis(2-(2-(2-methoxyethoxy)ethoxy)-ethyl)fluorenyldivinylene]-alt-4,7-(2,1,3-benzothiadiazole) with bright red emission and photosensitizing ability and poly[(4,4,9,9-tetrakis(4-(octyloxy)phenyl)-4,9-dihydro-s-indacenol-dithiophene-2,7-diyl)-alt-co-4,9-bis(thiophen-2-yl)-6,7-bis(4-(hexyloxy)phenyl)-thiadiazolo-quinoxaline] with strong near-infrared absorption and excellent photothermal conversion ability are co-loaded into one single CPN via encapsulation approach using lipid-polyethylene glycol as the matrix. The obtained co-loaded CPNs show sizes of around 30 nm with a high singlet oxygen quantum yield of 60.4% and an effective photothermal conversion efficiency of 47.6%. The CPN surface is further decorated with anti-HER2 affibody, which bestows the resultant anti-HER2-CPNs superior selectivity toward tumor cells with HER2 overexpression both in vitro and in vivo. Under light irradiation, the PDT and PTT show synergistic therapeutic efficacy, which provides new opportunities for the development of multifunctional biocompatible organic materials in cancer therapy.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
authors.forename: Guangxue
authors.initials: G
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, 300071, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
authors.forename: Junlong
authors.initials: J
authors.lastname: Geng
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, 300071, P. R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ding
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.|Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, Innovis, 136834, Singapore.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging; D006801:Humans; D006979:Hyperthermia, Induced; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010778:Photochemotherapy; D010789:Phototherapy; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism
chemical_list: D011108:Polymers; D018809:Proliferating Cell Nuclear Antigen
keywords: bioimaging; conjugated polymers; nanoparticles; photodynamic therapy; photothermal therapy