title: Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells.
abstract: Aristaless-like homeobox-4 (ALX4), a member of the Aristaless-like homeobox family, has been found to be involved in tumor cell proliferation, migration, and invasion. However, the role of ALX4 in hepatocellular carcinoma (HCC) remains largely unclear. Therefore, in this study we investigated the effects of ALX4 on HCC. The study results indicated that the expression of ALX4 was downregulated in HCC tissues and cell lines. Furthermore, we demonstrated that overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) in HCC cells. We also found that ALX4 had an inhibitory effect on the sonic hedgehog (Shh) signaling pathway. Taken together, the results suggest that ALX4 may be a promising target for HCC treatment.
authors.affiliation: Control of Nosocomial Infections, Hong-hui Hospital, Xian Jiaotong University College of MedicineXianP.R. China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Surgery, Hong-hui Hospital, Xian Jiaotong University College of MedicineXianP.R. China.
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Sun
authors.affiliation: Basic Medical College of Xian Jiaotong UniversityXianP.R. China.
authors.forename: Xiafen
authors.initials: X
authors.lastname: He
mesh_terms: D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics*; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C416676:ALX4 protein, human; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D053823:Hedgehog Proteins; C509239:SHH protein, human; D014157:Transcription Factors