title: [Alterations of serum neurospecific proteins concentrations in patients with metabolic syndrome].
abstract: OBJECTIVE
  Metabolic syndrome (MS) - is a complex of metabolic, hormonal and clinical disorders which are risk factors for cardiovascular disease. The study aimed to determine the markers NSE, GFAP, MMP-9 in patients with MS and to assess their prognostic value in the development of acute stroke.
  
  
  METHODS
  A cross-sectional analytical studyincluded 157 patients stratified into 4groups (control group, patients with MS, patients with ischemic stroke and patients with ischemic stroke and MS). Laboratory examinations included measurements of MS parameters(total cholesterol, blood glucose, cholesterol, HDL and LDL, triglycerides) and concentrations of neurospecific markers NSE, GFAP and MMP-9 by ELISA.
  
  
  CONCLUSIONS
  A relationship between MS and increased concentration of NSE is found. This indicates the presence of neuronal brain injury in patients with metabolic syndrome. There were no changesin the concentrations of GFAP and MMP-9 in patients with MS.
authors.affiliation: Karaganda State Medical University, Karaganda, Kazakhstan.
authors.forename: I A
authors.initials: IA
authors.lastname: Kadyrova
authors.affiliation: Karaganda State Medical University, Karaganda, Kazakhstan.
authors.forename: A S
authors.initials: AS
authors.lastname: Kadyrov
mesh_terms: D000328:Adult; D015415:Biomarkers; D001786:Blood Glucose; D002318:Cardiovascular Diseases / Q000097:blood*; D002784:Cholesterol; D003430:Cross-Sectional Studies; D005904:Glial Fibrillary Acidic Protein / Q000097:blood; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D012307:Risk Factors; D020521:Stroke; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C000628670:GFAP protein, human; D005904:Glial Fibrillary Acidic Protein; D014280:Triglycerides; D002784:Cholesterol; D020780:Matrix Metalloproteinase 9; D010751:Phosphopyruvate Hydratase