title: Effects ofMorinda officinalisPolysaccharide on Experimental Varicocele Rats.
abstract: Morinda officinalisis a traditional Chinese herbal medicine, which has been used to tonify the kidney and strengthen yang for a long time in China. In this study, the effects ofM. officinalisPolysaccharide (MOP) on experimental varicocele adolescent rats were investigated. The result showed that varicocele destroyed the structure of the seminiferous epithelium and decreased the TJ protein expression (Occludin, Claudin-11, and ZO-1), testosterone (T) concentration in the left testicular tissue and serum, and serum levels of inhibin B (INHB), while increasing the levels of cytokines (TGF-β3 and TNF-α) in the left testicular tissue, as well as serum levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and antisperm antibody (AsAb). MOP repaired the damaged seminiferous epithelium and TJ and reduced the levels of cytokines (TGF-β3 and TNF-α) as well as serum levels of GnRH, FSH, LH, and AsAb, while upregulating TJ protein expression, T level in the left testicular tissue and serum, and serum INHB levels. In summary, we conclude that MOP promotes spermatogenesis and counteracts the varicocele-induced damage to the seminiferous epithelium and TJ, probably via decreasing cytokines (TGF-β3 and TNF-α) levels and regulating the abnormal sex hormones levels in experimental varicocele rats.
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China; Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China; Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China.
authors.forename: Xiaozhen
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China; Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China; Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China; Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China.
authors.forename: Wei
authors.identifier: 0000-0003-2630-8145
authors.initials: W
authors.lastname: Wang