title: A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother.
abstract: The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.
authors.affiliation: Thrombosis Institute and National Hemophilia Center, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Assaf Arie
authors.initials: AA
authors.lastname: Barg
authors.affiliation: Thrombosis Institute and National Hemophilia Center, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Aviya Dvir
authors.initials: AD
authors.lastname: Ifrah
authors.affiliation: Department of Neonatology, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Tzipi
authors.initials: T
authors.lastname: Strauss
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center at Tel Hashomer, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Michal J
authors.initials: MJ
authors.lastname: Simchen
authors.affiliation: Department of Obstetrics & Gynecology, Infertility & IVF Unit, Sheba Medical Center at Tel Hashomer, Tel Aviv, Israel.
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
authors.affiliation: Thrombosis Institute and National Hemophilia Center, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Nurit
authors.initials: N
authors.lastname: Rosenberg
authors.affiliation: Thrombosis Institute and National Hemophilia Center, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gili
authors.initials: G
authors.lastname: Kenet
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D011247:Pregnancy; D060888:Real-Time Polymerase Chain Reaction; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000235:genetics*; D014019:Tissue Donors
chemical_list: D016824:Antigens, Human Platelet
keywords: HPA; Turner syndrome; neonatal thrombocytopenia; oocyte donor; surrogate pregnancy