title: Rethinking origin licensing.
abstract: Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
authors.affiliation: Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, United States.
authors.forename: Stephen P
authors.identifier: 0000-0002-2876-610X
authors.initials: SP
authors.lastname: Bell
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004268:DNA-Binding Proteins; D006801:Humans; D064110:Minichromosome Maintenance Proteins / Q000235:genetics; D051738:Origin Recognition Complex / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029867:Xenopus Proteins
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D051738:Origin Recognition Complex; D029867:Xenopus Proteins; D064110:Minichromosome Maintenance Proteins
keywords: CDC6; CDT1; DNA replication; MCM2-7; ORC; cell biology; human