title: Formulation and Optimization of Lansoprazole Pellets Using Factorial Design Prepared by Extrusion-Spheronization Technique Using Carboxymethyl Tamarind Kernel Powder.
abstract: BACKGROUND
  In the present study, Lansoprazole pellets were prepared employing a novel excipient Carboxymethyl tamarind kernel powder (CMTKP) using extrusion-spheronization technique. Various research studies including patents have been carried out on this polymer. Pellet formulation was optimized for formulation parameters (concentration of microcrystalline cellulose, CMTKP, croscarmellose sodium and isopropyl alcohol).
  
  
  METHODS
  Process parameters (speed and duration of spheronization) were optimized using factorial design. The pellets were evaluated for yield, bulk and tapped density, particle size, hardness, drug content, disintegration time and drug release.
  
  
  RESULTS
  The optimized batch showed 93.53% yield, 0.307 kg/cm2 hardness, 2.15 mm average particle size, 292 sec disintegration time and 90.46% drug content.
  
  
  CONCLUSIONS
  Drug release of the optimized batch (2F7) and marketed formulation (LANZOL cap) was found to be 82.33% and 80.07%, respectively. An accelerated study indicated that optimized formulation was stable.
authors.affiliation: Dept. of Pharmaceutics, D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune University, Pimpri, Pune, Maharashtra, India.
authors.forename: Sagar Sopanrao
authors.initials: SS
authors.lastname: Muley
authors.affiliation: Departmment of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra 411018, India.
authors.forename: Tanaji
authors.initials: T
authors.lastname: Nandgude
authors.affiliation: Departmment of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra 411018, India.
authors.forename: Sushilkumar
authors.initials: S
authors.lastname: Poddar
mesh_terms: D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D064747:Lansoprazole / Q000737:chemistry*; D010316:Particle Size; D010330:Patents as Topic; D029861:Tamarindus / Q000737:chemistry*
chemical_list: D005079:Excipients; D064747:Lansoprazole; D002482:Cellulose
keywords: Pelletization; carboxymethyl tamarind kernel powder; extrusion-spheronization; lansoprazole