title: Regional difference in sulcal infolding progression correlated with cerebral cortical expansion in cynomolgus monkey fetuses.
abstract: The present study aimed to specify the cerebral sulci developed by cortical expansion in cynomolgus monkey fetuses. The degree of sulcal infolding was evaluated by the gyrification index (GI), which was quantified using ex vivo magnetic resonance imaging. The correlation of cortical volume with the sulcal GI was most frequent during embryonic days (EDs) 100 to 120. Interestingly, the high correlation was marked during EDs 140 to 150 in restricted primary sulci in prefrontal, parietotemporal and medial temporal regions. The present results suggest that cortical expansion is involved in gyral demarcation by sulcal infolding, followed by the sulcal infolding progression in phylogenetically-newer cortices.
authors.affiliation: Department of Nutrition, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sawada
authors.affiliation: Department of Anatomy and Developmental Neurobiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Fukunishi
authors.affiliation: Shin Nippon Biomedical Laboratories, Kagoshima, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kashima
authors.affiliation: Shin Nippon Biomedical Laboratories, Kagoshima, Japan.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Imai
authors.affiliation: Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.|Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, Osaka University, Suita, Osaka, Japan.
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Saito
authors.affiliation: Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, QST, Chiba, Japan.
authors.forename: Ichio
authors.initials: I
authors.lastname: Aoki
authors.affiliation: Department of Anatomy and Developmental Neurobiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fukui
mesh_terms: D000818:Animals; D001931:Brain Mapping; D004622:Embryo, Mammalian; D005260:Female; D005333:Fetus; D007090:Image Interpretation, Computer-Assisted; D008252:Macaca fascicularis / Q000033:anatomy & histology* / Q000254:growth & development; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000254:growth & development; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000254:growth & development; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000254:growth & development
keywords: cerebral cortex; gyrification; magnetic resonance imaging; non-human primate; sulcus