title: Changes in the cerebellar and cerebro-cerebellar circuit in type 2 diabetes.
abstract: Currently, 422 million adults suffer from diabetes worldwide, leading to tremendous disabilities and a great burden to families and society. Functional and structural MRIs have demonstrated that patients with type 2 diabetes mellitus (T2DM) exhibit abnormalities in brain regions in the cerebral cortex. However, the changes of cerebellar anatomical connections in diabetic patients remains unclear. In the current study, diffusion tensor imaging deterministic tractography and statistical analysis were employed to investigate abnormal cerebellar anatomical connections in diabetic patients. This is the first study to investigate the altered cerebellar anatomical connectivity in T2DM patients. Decreased anatomical connections were found in the cerebellar and cerebro-cerebellar circuits of T2DM patients, providing valuable new insights into the potential neuro-pathophysiology of diabetes-related motor and cognitive deficits.
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fang
authors.affiliation: Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Chinese Traditional Medicine, Guangzhou, Guangdong, 510405, China.
authors.forename: Jie
authors.initials: J
authors.lastname: An
authors.affiliation: Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Chinese Traditional Medicine, Guangzhou, Guangdong, 510405, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tan
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China.
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Zeng
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Chinese Traditional Medicine, Guangzhou, Guangdong, 510405, China. Electronic address: qiu-sj@163.com.
authors.forename: Shijun
authors.initials: S
authors.lastname: Qiu
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China. Electronic address: dwhu@nudt.edu.cn.
authors.forename: Dewen
authors.initials: D
authors.lastname: Hu
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000473:pathology
keywords: Cerebellar circuit; Cerebro-cerebellar circuit; Diffusion tensor imaging; Motor and cognitive deficit; Type 2 diabetes