title: Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia.
abstract: The primary goal of this study was to determine the median effective dose (ED50) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 μg sufentanil in 7 ml saline. Effective analgesia was defined as a score ≤ 10 mm within 15 min on a 100-mm visual analogue pain scale. Using the isotonic regression estimator method, the ED50of chloroprocaine for the spinal component of a combined spinal-epidural for labour was calculated to be median (95%CI) 12.0 (9.3-17.0) mg.
authors.affiliation: Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Coppens
authors.affiliation: Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Anssens
authors.affiliation: Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Parashchanka
authors.affiliation: Department of Uro-Gynaecology, Ghent University Hospital, Ghent, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Roelens
authors.affiliation: Biostatistics Unit, Department of Public Health, Ghent University Hospital, Ghent, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Deschepper
authors.affiliation: Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: De Hert
authors.affiliation: Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: P F
authors.initials: PF
authors.lastname: Wouters
mesh_terms: D000293:Adolescent; D000328:Adult; D015360:Analgesia, Epidural / Q000379:methods*; D016362:Analgesia, Obstetrical / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D008875:Middle Aged; D010147:Pain Measurement; D011247:Pregnancy; D011343:Procaine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D011343:Procaine; C004616:chloroprocaine
keywords: chloroprocaine metabolism; combined spinal-epidural; labour analgesia; median effective dose