title: Copper(i)/TF-BiphamPhos catalyzed asymmetric nitroso Diels-Alder reaction.
abstract: A highly efficient enantioselective nitroso Diels-Alder reaction of 6-methyl-2-nitroso pyridine with various 1,3-dienes was successfully developed using a Cu(i)/(S)-TF-BiphamPhos complex as the catalyst. For most of the cyclic dienes, synthetically important heterocyclic 3,6-dihydro-1,2-oxazines were obtained in high yields with excellent regio-, diastereo- and enantioselectivities. Acyclic 2-silyloxy-1,3-diene also worked well in the reaction.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. cjwang@whu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tao
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang