title: Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro.
abstract: Chicory inulin is a naturally occurring fructan that is conducive to glucose and lipid metabolism in patients with diabetes mellitus. This study aims to investigate the mechanism by which chicory inulin improves glucolipid metabolism in diabetic conditions.
  
  
  
  Rats were injected with streptozotocin and fed with high fat diet to induce diabetes, and then administrated with different doses of chicory inulin for 8 weeks. The glycometabolism and lipid metabolism parameters were determined, the activity of insulin receptor substrate (IRS) and mitogen-activated protein kinase (MAPK) pathways were examined by western blot. The effect of chicory inulin on glucose uptake of myoblast and hepatocyte were also measured in vitro. Data were analyzed by student's t-test or one-way analysis of variance followed by the Bonferroni post-hoc testing. The results showed that chicory inulin improved glucolipid metabolism, and it activated IRS but suppressed the MAPK pathways in vivo and in vitro.
  
  
  
  Our study demonstrates that chicory inulin, as a nutritional supplement, may be beneficial for the patients with type 2 diabetes mellitus, and the metabolism-modulatory effect seems to be related with the inhibition of JNK and P38 MAPK pathways.
authors.affiliation: College of Food Science, Shenyang Agricultural University, Shenyang, P. R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Ning
authors.affiliation: School of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, P. R. China.
authors.forename: Xiyao
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Food Science, Shenyang Agricultural University, Shenyang, P. R. China.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.affiliation: College of Food Science, Shenyang Agricultural University, Shenyang, P. R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Mu
authors.affiliation: College of Food Science, Shenyang Agricultural University, Shenyang, P. R. China.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Food Science, Shenyang Agricultural University, Shenyang, P. R. China.|College of Food Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, P. R. China.
authors.forename: Suwen
authors.initials: S
authors.lastname: Liu
authors.affiliation: College of Food Science, Shenyang Agricultural University, Shenyang, P. R. China.|Food Inspection Monitoring Center of Zhuanghe, Dalian, P. R. China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Zhu
authors.affiliation: College of Food Science, Shenyang Agricultural University, Shenyang, P. R. China.
authors.forename: Xianjun
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D018651:Cichorium intybus / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism; D019587:Dietary Supplements; D004789:Enzyme Activation / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D007444:Inulin / Q000494:pharmacology*; D048670:MAP Kinase Kinase 4 / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D008297:Male; D017207:Rats, Sprague-Dawley; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007444:Inulin; D048051:p38 Mitogen-Activated Protein Kinases; D048670:MAP Kinase Kinase 4
keywords: Chicory inulin; Diabetes; Glycometabolism; Lipid metabolism; Mitogen-activated protein kinase