title: Resveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.
abstract: The results of human clinical trials have revealed that the effects of resveratrol on adipokines are inconsistent. Our objective was to elucidate the role of resveratrol supplementation on adipokines through a systematic review and a meta-analysis of available randomized placebo-controlled trials (RCTs).1The search included PubMed-MEDLINE, SCOPUS and ISI web of sciences database till up to 6th November 2016. Weight mean differences (WMD)2were calculated for net changes in adipokines using fixed-effects or random-effects models; meta-regression analysis and publication bias were conducted in accordance with standard methods. Nine RCTs with 11 treatment arms were eligible for inclusion in this systematic review and meta-analysis. Meta-analysis of data from 10 treatment arms showed a significant change in plasma adiponectin concentrations following resveratrol supplementation (WMD: 1.10μg/ml, 95%CI: 0.88, 1.33, p<0.001); Q=11.43, I2=21.29%, p=0.247). There was a significant greater adiponectin-reducing effect in trials with higher than or equal to 100mg/day (WMD: 1.11μg/ml, 95%CI: 0.88, 1.34, p<0.001), versus those with less than 100 mg/day dosage (WMD: 0.84μg/ml, 95%CI: -0.62, 2.31, p=0.260). Meta-analysis of data from 5 treatment arms did not find any significant change in plasma leptin concentrations following resveratrol supplementation (WMD: 3.77ng/ml, 95% CI: -2.28, 9.83, p=0.222; Q=8.00, I2=50.01%). Resveratrol significantly improves adiponectin but does not affect leptin concentrations. Additional studies are required to further evaluate the potential benefits of resveratrol on adipokines in humans.
authors.affiliation: Department of Clinical Nutrition, Shiraz University of Medical Sciences, School of Nutrition and Food Sciences, Shiraz, Iran. Electronic address: Mohsen.nut85@yahoo.com.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mohammadi-Sartang
authors.affiliation: Department of Clinical Nutrition, Shiraz University of Medical Sciences, School of Nutrition and Food Sciences, Iran. Electronic address: Zohreh.mazloom@gmail.com.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mazloom
authors.affiliation: Department of Community Nutrition, Shiraz University of Medical Sciences, School of Nutrition and Food Sciences, Iran. Electronic address: Zahra_2043@yahoo.com.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sohrabi
authors.affiliation: Department of Clinical Nutrition, Shiraz University of Medical Sciences, School of Nutrition and Food Sciences, Shiraz, Iran. Electronic address: Saeedsherafatmanesh@gmail.com.
authors.forename: Saeed
authors.initials: S
authors.lastname: Sherafatmanesh
authors.affiliation: Department of Community Nutrition, Shiraz University of Medical Sciences, School of Nutrition and Food Sciences, Shiraz, Iran. Electronic address: Reza93barati@gmail.com.
authors.forename: Reza
authors.initials: R
authors.lastname: Barati-Boldaji
mesh_terms: D054392:Adipokines / Q000097:blood*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use*; D019587:Dietary Supplements; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D054392:Adipokines; D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D000077185:Resveratrol
keywords: Adipokines; Adiponectin; Leptin; Resveratrol