title: Transient symptomatic worsening by atropine in opsoclonus-myoclonus syndrome.
abstract: Opsoclonus-myoclonus syndrome (OMS) is characterized by abnormal eye and systemic involuntary movements, as well as cerebellar ataxia. Some sedatives and anesthetics worsen movements associated with OMS, while there is no known report of a negative effect of atropine. We report on sedation in two patients with OMS. Involuntary movements were transiently worsened after using atropine with midazolam or thiamylal in both, but were not seen when atropine was not used. We speculated that atropine has the potential to exacerbate involuntary movements in OMS due to vulnerability to this agent via unknown mechanisms.
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Hirotsugu
authors.identifier: http://orcid.org/0000-0002-1375-5344
authors.initials: H
authors.lastname: Miyoshi
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakamura
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Yamaga
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Haraki
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Yasuda
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamada
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamoto
mesh_terms: D000759:Adjuvants, Anesthesia / Q000009:adverse effects*; D000927:Anticonvulsants / Q000627:therapeutic use; D001285:Atropine / Q000009:adverse effects*; D002675:Child, Preschool; D002998:Clonazepam / Q000627:therapeutic use; D054810:Deep Sedation / Q000009:adverse effects / Q000379:methods; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D053578:Opsoclonus-Myoclonus Syndrome / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D000759:Adjuvants, Anesthesia; D000927:Anticonvulsants; D005938:Glucocorticoids; D002998:Clonazepam; D001285:Atropine; D011239:Prednisolone
keywords: anticholinergic syndrome; atropine; opsoclonus-myoclonus syndrome