title: Capsule endoscopy and single-balloon enteroscopy in small bowel diseases: Competing or complementary?
abstract: OBJECTIVE
  To evaluate diagnostic yields of capsule endoscopy (CE) and/or single-balloon enteroscopy (SBE) in patients with suspected small bowel diseases.
  
  
  METHODS
  We retrospectively analyzed 700 patients with suspected small bowel diseases from September 2010 to March 2016. CE, SBE, or SBE with prior CE was performed in 401, 353, and 47 patients, respectively. Data from clinical and endoscopy records were collected for analysis. Indications, procedure times, diagnostic yields, and complications were summarized and evaluated.
  
  
  RESULTS
  The overall diagnostic yield for the CE group was 57.6%. The diagnostic yield of CE in patients with obscure gastrointestinal bleeding (OGIB) was significantly greater than that in patients with no bleeding (70.5%vs43.8%,P< 0.01). The overall diagnostic yield of SBE was 69.7%. There was no difference in the diagnostic yield of SBE between patients with OGIB and those with no bleeding (72.5%vs68.9%,P= 0.534). Forty-seven patients underwent CE prior to SBE. Among them, the diagnostic yield of SBE with positive findings on prior CE was 93.3%. In addition, SBE detected two cases with superficial ulcer and erosive lesions in the small bowel, which were missed by CE. However, one case with lymphoma and two with Crohn's disease were not confirmed by SBE. The rate of capsule retention was 2.0%. There were no significant complications during or after SBE examinations.
  
  
  CONCLUSIONS
  SBE is a safe and effective technique for diagnosing small bowel diseases. SBE with prior CE seemed to improve the diagnostic yield of small bowel diseases.
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Ma
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Xu
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jie-Wen
authors.initials: JW
authors.lastname: Su
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Jiang
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jian-Xia
authors.initials: JX
authors.lastname: Jiang
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Dao-Quan
authors.initials: DQ
authors.lastname: Zhang
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ding
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Xu
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Tao
authors.affiliation: Jing-Jing Ma, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053704:Capsule Endoscopy; D003424:Crohn Disease / Q000175:diagnosis; D004381:Duodenal Ulcer / Q000175:diagnosis; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis*; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis*; D007414:Intestinal Neoplasms / Q000175:diagnosis; D007421:Intestine, Small / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000071085:Single-Balloon Enteroscopy; D055815:Young Adult
keywords: Balloon-assisted enteroscopy; Capsule endoscopy; Diagnosis; Single-balloon enteroscopy; Small bowel diseases