title: Spanish version of the Actinic Keratosis Quality of Life questionnaire.
abstract: BACKGROUND
  Patient-reported outcome measures are very important outcomes. For specific diseases, health-related quality of life-instruments (HRQoL) are increasingly used to provide data on patients' overall perceptions of the course of a given disease. Actinic keratoses (AKs) are common keratotic lesions that occur on chronically sunlight-exposed skin. Only few studies regarding HRQoL in AKs have been made.
  
  
  OBJECTIVE
  In order to be able to compare HRQoL among different countries and cultures, we aimed to translate and validate the Actinic Keratosis Quality of Life (AKQoL) questionnaire into Spanish and quantify the impairment caused by AKs in Spanish patients.
  
  
  METHODS
  The AKQoL was translated. Then, 15 patients with AKs were interviewed to ensure cultural adaption before it was tested in one hundred patients with AK lesions at the Melanoma Unit of Hospital Clinic in Barcelona.
  
  
  RESULTS
  Validation showed high interitem correlations, as well as a high correlation of each item and the total score. Internal consistency (Cronbach's coefficient alpha) was also high at 0.91 and an alpha value of 0.90 at retest. The test-retest correlation was 0.96, and the intraclass coefficient was 0.98.
  
  
  CONCLUSIONS
  The presented data support the AKQoL Spanish version as a valid and reliable HRQoL questionnaire for the description of AK-related QoL and may provide a method for comparison of AK specific QoL between different cultures and countries.
authors.affiliation: Melanoma Unit, Dermatology Department, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer), Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Alarcon
authors.affiliation: Department of Dermatology, University Hospital Zealand, University of Copenhagen, Roskilde, Denmark.|Department of Dermato-Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: G R
authors.initials: GR
authors.lastname: Vinding
authors.affiliation: Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
authors.forename: K B
authors.initials: KB
authors.lastname: Christensen
authors.affiliation: Department of Dermatology, University Hospital Zealand, University of Copenhagen, Roskilde, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Esmann
authors.affiliation: Melanoma Unit, Dermatology Department, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer), Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Malvehy
authors.affiliation: Melanoma Unit, Dermatology Department, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer), Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Puig
authors.affiliation: Department of Dermatology, University Hospital Zealand, University of Copenhagen, Roskilde, Denmark.
authors.forename: G B E
authors.initials: GBE
authors.lastname: Jemec
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D055623:Keratosis, Actinic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires