title: Mononuclear phagocyte subpopulations in the mouse kidney.
abstract: Mononuclear phagocytes are the most common cells in the kidney associated with immunity and inflammation. Although the presence of these cells in the kidney has been known for decades, the study of mononuclear phagocytes in the context of kidney function and dysfunction is still at an early stage. The purpose of this review is to summarize the present knowledge regarding classification of these cells in the mouse kidney and to identify relevant questions that would further advance the field and potentially lead to new opportunities for treatment of acute kidney injury and other kidney diseases.
authors.affiliation: Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.|Department of Nephrology Research and Training Center; University of Alabama at Birmingham, Birmingham, Alabama; and.
authors.forename: James F
authors.initials: JF
authors.lastname: George
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.|Department of Nephrology Research and Training Center; University of Alabama at Birmingham, Birmingham, Alabama; and.
authors.forename: Jeremie M
authors.initials: JM
authors.lastname: Lever
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; agarwal@uab.edu.|Department of Nephrology Research and Training Center; University of Alabama at Birmingham, Birmingham, Alabama; and.|Department of Veterans Affairs, Birmingham, Alabama.
authors.forename: Anupam
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D058186:Acute Kidney Injury / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D000066670:Cell Plasticity; D005355:Fibrosis; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007668:Kidney / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009393:Nephritis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010586:Phagocytes / Q000145:classification / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D011971:Receptors, Immunologic
keywords: acute kidney injury; inflammation; ischemia-reperfusion; macrophages; renal fibrosis