title: Chrysin prevents brain damage caused by global cerebralischemia/reperfusion in a C57BL/J6 mouse model.
abstract: OBJECTIVE
  The present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model.
  
  
  METHODS
  A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days. In the CRS group, CRS (50 mg/kg) was given for 10 days without carotid occlusion. In the CRS + I/R group bilateral carotid arteries were clipped for 15 min and the mice were also treated with CRS (50 mg/kg) for 10 days. All of the rats were sacrificed under anesthesia on day 10, and neurodegenerative histological changes in the brain and tissue levels of oxidants and antioxidants were evaluated.
  
  
  RESULTS
  CRS treatment significantly reversed the oxidative effects of I/R and inhibited the development of neurodegenerative histopathologies. In the CRS + I/R group, the decrease in TBARS levels and increase in GSH levels were similar to those in the SH group.
  
  
  CONCLUSIONS
  Treatment with CRS can positively affect the neural system of mice and it can be used for the treatment of global cerebral I/R.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Durak
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Mustafa Namık
authors.initials: MN
authors.lastname: Öztanır
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy, İnönü University, Malatya, Turkey.
authors.forename: Neşe
authors.initials: N
authors.lastname: Başak Türkmen
authors.affiliation: Department of Pharmacy, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Çiftçi
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Taşlıdere
authors.affiliation: Department of Neurology, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tecellioğlu
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Önder
mesh_terms: D000818:Animals; D001921:Brain; D002545:Brain Ischemia; D005419:Flavonoids; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents; D018384:Oxidative Stress; D051381:Rats; D015427:Reperfusion Injury
chemical_list: D005419:Flavonoids; D018696:Neuroprotective Agents; C043561:chrysin
keywords: C57 BL /J6 mice; Chrysin; global ischemia/reperfusion; neuroprotection