title: 18F-FLT and18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats.
abstract: The present study aimed to evaluate the early therapeutic effects of chemotherapy on Walker 256 tumor-bearing Wistar rats via F-18-fluoro-3'-deoxy-3'-L-fluorothymidine (18F-FLT) and F-18-fluoro-deoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) imaging. Walker 256 tumor-bearing Wistar rats were subjected to18F-FLT and18F-FDG PET-CT imaging prior to and 24 and 48 h after epirubicin chemotherapy.18F-FLT and18F-FDG uptake [tumor/muscle (T/M)], the percentage of injected dose per gram (% ID/g), and the Ki-67 labeling index (LI-Ki-67) were quantitatively determined for each rat prior to and following epirubicin chemotherapy. The correlation between % ID/g and tumor LI-Ki-67 was analyzed. Both18F-FLT and18F-FDG tumor uptake decreased significantly at 24 and 48 h after chemotherapy (P<0.01 and P<0.05, respectively). LI-Ki-67 also significantly reduced 24 and 48 h after chemotherapy (P<0.001). Furthermore,18F-FLT and18F-FDG T/M tumor uptake correlated positively with LI-Ki-67 before and after chemotherapy (r=0.842 and 0.813, respectively). During the early post-chemotherapy stage,18F-FLT and18F-FDG uptake in Walker 256 tumors reduced significantly, which correlated positively with the tumor cell proliferative activity.
authors.affiliation: Department of Nuclear Medicine, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors.forename: Weina
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Nuclear Medicine, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors.forename: Shupeng
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xin
authors.affiliation: Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Guo
keywords: F-18-fluoro-3′-deoxy-3′-L-fluorothymidine; F-18-fluoro-deoxyglucose; Ki-67; chemotherapy; positron emission tomography-computed tomography; proliferation