title: Maternal c-reactive protein and oxidative stress markers as predictors of delivery latency in patients experiencing preterm premature rupture of membranes.
abstract: OBJECTIVE
  To evaluate the usefulness of maternal serum c-reactive protein (CRP), lipid peroxide, and oxygen radical absorbance capacity (ORAC), to predict the interval between membrane rupture and delivery in patients with preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  The present prospective study included patients with singleton pregnancies experiencing PPROM at earlier than 34 weeks of pregnancy who underwent spontaneous vaginal delivery between August 1, 2010 and July 31, 2013 at Chonnam National University Hospital, Republic of Korea. Patients were categorized based on whether delivery occurred within 3 days of PPROM or after. CRP levels, lipid peroxide (using malondialdehyde levels), ORAC, protein carbonyl, and other potential risk factors were compared between the groups.
  
  
  RESULTS
  There were 72 patients included. Maternal serum CRP levels, malondialdehyde levels, and Bishop Score were higher in patients who underwent delivery within 3 days (all P<0.05); ORAC levels were lower among these patients (P=0.002). A receiver operating characteristic curve analysis showed that CRP, malondialdehyde, and ORAC levels were predictive of delivery within 3 days after PPROM.
  
  
  CONCLUSIONS
  Maternal serum CRP, malondialdehyde, and ORAC levels at admission were useful in predicting the latent period in patients with PPROM.
authors.affiliation: Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Hyun Kyung
authors.initials: HK
authors.lastname: Ryu
authors.affiliation: Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Moon
authors.affiliation: Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Hyun Ji
authors.initials: HJ
authors.lastname: Heo
authors.affiliation: Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Jong Woon
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Yoon Ha
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000328:Adult; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis*; D036861:Delivery, Obstetric; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis*; D005865:Gestational Age; D006801:Humans; D016015:Logistic Models; D008315:Malondialdehyde / Q000097:blood*; D015999:Multivariate Analysis; D018384:Oxidative Stress; D000072257:Oxygen Radical Absorbance Capacity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011446:Prospective Studies; D012372:ROC Curve; D056910:Republic of Korea; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D002097:C-Reactive Protein
keywords: C-reactive protein; Latent period; Lipid peroxide; Oxidative stress; Oxygen radical absorbance capacity; Premature rupture of membranes