title: Simulation and evaluation of rupturable coated capsules by finite element method.
abstract: The objective of this study was to simulate and evaluate the burst behavior of rupturable coated capsules by finite element method (FEM). Film and coated capsules were prepared by dip-coating method and their dimensions were determined by stereomicroscope. Mechanical properties of the film were measured by tensile test and used as material properties of FEM models. Swelling pressure was determined by restrained expansion method and applied to the internal surface of FEM models. Water uptake of coated capsules was determined to study the formation of internal pressure. Burst test and in vitro dissolution was used to verify the FEM models, which were used to study and predict the coating burst behavior. Simulated results of coating burst behavior were well agreed with the experiment results. Swelling pressure, material properties and dimensions of coating had influence on the maximum stress. Burst pressure and critical L-HPC content were calculated for burst prediction and formulation optimization. FEM simulation was a feasible way to simulate and evaluate the burst behavior of coated capsules.
authors.affiliation: School of Pharmacy, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fang
authors.affiliation: School of Pharmacy, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Shen
authors.affiliation: School of Pharmacy, Zhejiang University of Technology, Hangzhou, China. Electronic address: tianranyaowu@zjut.edu.cn.
authors.forename: Weiguang
authors.initials: W
authors.lastname: Shan
mesh_terms: D002214:Capsules / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003198:Computer Simulation; D020342:Finite Element Analysis; D008962:Models, Theoretical; D011312:Pressure; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D002214:Capsules; D014867:Water
keywords: Burst behavior; Coated capsules; Finite element method; Mechanical properties; Pulsatile drug release; Swelling pressure