title: Development of a Reference Image Collection Library for Histopathology Image Processing, Analysis and Decision Support Systems Research.
abstract: Histopathology image processing, analysis and computer-aided diagnosis have been shown as effective assisting tools towards reliable and intra-/inter-observer invariant decisions in traditional pathology. Especially for cancer patients, decisions need to be as accurate as possible in order to increase the probability of optimal treatment planning. In this study, we propose a new image collection library (HICL-Histology Image Collection Library) comprising 3831 histological images of three different diseases, for fostering research in histopathology image processing, analysis and computer-aided diagnosis. Raw data comprised 93, 116 and 55 cases of brain, breast and laryngeal cancer respectively collected from the archives of the University Hospital of Patras, Greece. The 3831 images were generated from the most representative regions of the pathology, specified by an experienced histopathologist. The HICL Image Collection is free for access under an academic license at http://medisp.bme.teiath.gr/hicl/ . Potential exploitations of the proposed library may span over a board spectrum, such as in image processing to improve visualization, in segmentation for nuclei detection, in decision support systems for second opinion consultations, in statistical analysis for investigation of potential correlations between clinical annotations and imaging findings and, generally, in fostering research on histopathology image processing and analysis. To the best of our knowledge, the HICL constitutes the first attempt towards creation of a reference image collection library in the field of traditional histopathology, publicly and freely available to the scientific community.
authors.affiliation: Medical Image and Signal Processing Laboratory (MEDISP), Department of Biomedical Engineering, Technological Educational Institute of Athens, Ag. Spyridonos Street, 122 10, Egaleo, Athens, Greece.
authors.forename: Spiros
authors.initials: S
authors.lastname: Kostopoulos
authors.affiliation: Department of Pathology, University Hospital of Patras, Rio, 265 04, Patras, Greece.
authors.forename: Panagiota
authors.initials: P
authors.lastname: Ravazoula
authors.affiliation: Medical Image and Signal Processing Laboratory (MEDISP), Department of Biomedical Engineering, Technological Educational Institute of Athens, Ag. Spyridonos Street, 122 10, Egaleo, Athens, Greece.
authors.forename: Pantelis
authors.initials: P
authors.lastname: Asvestas
authors.affiliation: Medical Image and Signal Processing Laboratory (MEDISP), Department of Biomedical Engineering, Technological Educational Institute of Athens, Ag. Spyridonos Street, 122 10, Egaleo, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kalatzis
authors.affiliation: Medical Image and Signal Processing Laboratory (MEDISP), Department of Biomedical Engineering, Technological Educational Institute of Athens, Ag. Spyridonos Street, 122 10, Egaleo, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Xenogiannopoulos
authors.affiliation: Medical Image and Signal Processing Laboratory (MEDISP), Department of Biomedical Engineering, Technological Educational Institute of Athens, Ag. Spyridonos Street, 122 10, Egaleo, Athens, Greece.
authors.forename: Dionisis
authors.initials: D
authors.lastname: Cavouras
authors.affiliation: Medical Image and Signal Processing Laboratory (MEDISP), Department of Biomedical Engineering, Technological Educational Institute of Athens, Ag. Spyridonos Street, 122 10, Egaleo, Athens, Greece. dimglo@teiath.gr.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Glotsos
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D020000:Decision Support Systems, Clinical; D003936:Diagnosis, Computer-Assisted; D005103:Expert Systems; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012984:Software
keywords: Brain cancer; Breast cancer; Cancer; Computer-aided diagnosis; Histology image collection; Laryngeal cancer; Microscopy