title: ADAMTS-4 in central nervous system pathologies.
abstract: ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs type 4) is a metalloproteinase specialized in the degradation of chondroitin sulfate proteoglycans, contributing to cartilage breakdown during arthritis. In this review, we first focus on the modifications of ADAMTS-4 expression during CNS physiological and pathological conditions, including chronic diseases and injuries. Then, we discuss the contributions of ADAMTS-4 to mechanisms mediating neuroplasticity, neuroinflammation and neurodegeneration during spinal cord injury, ischemic stroke, amyotrophic lateral sclerosis and Alzheimer's disease. Here, we provide an overview of ADAMTS-4 functions and effects in the CNS, and we discuss directions for future studies and treatments. Overall, this review highlights that ADAMTS-4 is a unique multifaceted metalloproteinase which influences various CNS disease pathophysiologies. © 2017 Wiley Periodicals, Inc.
authors.affiliation: A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. BOX 1627, 70211, Kuopio, Finland.
authors.forename: Sighild
authors.initials: S
authors.lastname: Lemarchant
authors.affiliation: A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. BOX 1627, 70211, Kuopio, Finland.
authors.forename: Sara
authors.initials: S
authors.lastname: Wojciechowski
authors.affiliation: INSERM, INSERM UMR-S 919, "Serine Proteases and Pathophysiology of the Neurovascular Unit", University of Caen Basse-Normandie, GIP Cyceron, Bd H. Becquerel, BP 5229, 14074, Caen Cedex, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Vivien
authors.affiliation: A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. BOX 1627, 70211, Kuopio, Finland.
authors.forename: Jari
authors.initials: J
authors.lastname: Koistinaho
mesh_terms: D000071121:ADAMTS4 Protein; D000818:Animals; D002493:Central Nervous System Diseases / Q000378:metabolism*; D006801:Humans
chemical_list: D000071121:ADAMTS4 Protein
keywords: ADAMTS-4; acute CNS injuries; amyotrophic lateral sclerosis; neurodegeneration; neuroinflammation; neuroplasticity