title: Vaccination against infectious bronchitis virus: A continuous challenge.
abstract: Infectious bronchitis virus (IBV) is a significant respiratory pathogen of commercial poultry that causes millions of dollars in lost revenue worldwide each year. Even though the poultry industry extensively vaccinates against IBV, emergence of new serotypes and variants continually occur, making control of the disease difficult. Current mass application strategies for IBV vaccines are inefficient and frequently result in vaccination failures. Novel vaccine technology development has been slow, and is hindered by the constraints of large-scale poultry production. Further complicating the situation is the lack of knowledge of IBV protein and host cell interactions, making targeted vaccine intervention strategies near impossible. Taken together, it is easy to see why this disease remains significant in poultry production. This review outlines the current situation as it relates to IBV control, including vaccination, vaccines, and development of immunity, and recent developments in vaccine technology that may provide better protection in the future.
authors.affiliation: Department of Population Health, Poultry Diagnostic and Research Center, College of Veterinary Medicine, The University of Georgia, 953 College Station Rd., Athens, GA, 30602, USA; Department of Poultry Science, College of Agricultural and Environmental Sciences, The University of Georgia, 210 Cedar St., Athens, GA, 30602, USA. Electronic address: brian89@uga.edu.
authors.forename: Brian
authors.initials: B
authors.lastname: Jordan
mesh_terms: D000818:Animals; D018352:Coronavirus Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D007109:Immunity; D001351:Infectious bronchitis virus / Q000276:immunology*; D011200:Poultry; D011201:Poultry Diseases / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014765:Viral Vaccines
keywords: Infectious bronchitis virus; Vaccination; Vaccine