title: Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy.
abstract: Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HA-SPIONs. When incubated with CD44 HA receptor-overexpressing MDA-MB-231 cells in vitro, HA-SPIONs exhibited significant specific cellular uptake and specific accumulation confirmed by Prussian blue staining. The in vitro and in vivo results of magnetic resonance imaging and photothermal ablation demonstrated that HA-SPIONs exhibited significant negative contrast enhancement on T2-weighted magnetic resonance imaging and photothermal effect targeted CD44 HA receptor-overexpressing breast cancer. All these results indicated that HA-SPIONs have great potential for effective diagnosis and treatment of cancer.
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
authors.forename: Rui-Meng
authors.initials: RM
authors.lastname: Yang
authors.affiliation: School of Materials Science and Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, China.
authors.forename: Chao-Ping
authors.initials: CP
authors.lastname: Fu
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
authors.forename: Jin-Zhi
authors.initials: JZ
authors.lastname: Fang
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Xu
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Wei
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Tang
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
authors.forename: Xin-Qing
authors.initials: XQ
authors.lastname: Jiang
authors.affiliation: School of Materials Science and Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D008807:Mice, Inbred BALB C; D000068936:Theranostic Nanomedicine / Q000379:methods; D023041:Xenograft Model Antitumor Assays
chemical_list: C497483:CD44 protein, human; D003287:Contrast Media; D003911:Dextrans; D018960:Hyaluronan Receptors; D058185:Magnetite Nanoparticles; D006820:Hyaluronic Acid; C065507:ferumoxides
keywords: bioactive glycosaminoglycan; breast carcinoma; cellular uptake; iron oxide nanoparticles; magnetic resonance imaging; surface functionalization