title: Relationship between the uptake of18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs.
abstract: OBJECTIVE
  The purpose of this study was to determine the distribution of 4-borono-2-18F-fluoro-phenylalanine (18F-BPA) and L-[methyl-11C] methionine (11C-Met) in normal organs and tumors and to evaluate the usefulness of11C-Met/PET in screening potential candidates for boron neutron capture therapy (BNCT).
  
  
  METHODS
  Seven patients who had at least one histologically confirmed head and neck tumor were included in this study. They underwent both whole-body18F-BPA-PET/CT and11C-Met-PET/CT within a span of 6 months. Uptake was evaluated using the maximum standardized uptake value (SUVmax). Regions of interest (ROIs) were placed within the tumors and target organs of brain, thyroid, submandibular gland, lung, liver, esophagus, stomach pancreas, spleen, muscle, and bone marrow.
  
  
  RESULTS
  The tumor SUVmax of FBPA and11C-Met showed strong correlation (r2= 0.72, P = 0.015). Although18F-BPA and11C-Met showed markedly different uptake in some organs (submandibular gland, liver, heart, stomach pancreas, spleen, and bone marrow), the uptake of11C-Met was consistently higher than that of18F-BPA in these cases.
  
  
  CONCLUSIONS
  11C-Met PET/CT might be used instead of18F-BPA PET/CT to predict the accumulation of10B in tumors and to select candidates for BNCT. However, it would not be suitable for evaluating accumulation in some normal organs. Therefore, the18F-BPA-PET study remains a prerequisite for BNCT. This is the first report of the correlation between18F-BPA and11C-Met accumulation.
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.|Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. hikurihancc@gmail.com.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Itami
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Hyogo, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Sasaki
authors.affiliation: Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Arai
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugimura
mesh_terms: D000328:Adult; D000368:Aged; D001896:Boron Compounds / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005632:Fructose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008715:Methionine / Q000493:pharmacokinetics*; D008875:Middle Aged; D058958:Organs at Risk / Q000528:radiation effects*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D011879:Radiotherapy Dosage; D014018:Tissue Distribution; D055815:Young Adult
chemical_list: C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005632:Fructose; D008715:Methionine