title: Positive Airway Pressure Therapies and Hospitalization in Chronic Obstructive Pulmonary Disease.
abstract: Hospitalization of patients with chronic obstructive pulmonary disease creates a huge healthcare burden. Positive airway pressure therapy is sometimes used in patients with chronic obstructive pulmonary disease, but the possible impact on hospitalization risk remains controversial. We studied the hospitalization risk of patients with chronic obstructive pulmonary disease before and after initiation of various positive airway pressure therapies in a "real-world" bioinformatics study.
  
  
  
  We performed a retrospective analysis of administrative claims data of hospitalizations in patients with chronic obstructive pulmonary disease who received or did not receive positive airway pressure therapy: continuous positive airway pressure, bilevel positive airway pressure, and noninvasive positive pressure ventilation using a home ventilator.
  
  
  
  The majority of 1,881,652 patients with chronic obstructive pulmonary disease (92.5%) were not receiving any form of positive airway pressure therapy. Prescription of bilevel positive airway pressure (1.5%), continuous positive airway pressure (5.6%), and noninvasive positive pressure ventilation (<1%) in patients with chronic obstructive pulmonary disease demonstrated geographic-, sex-, and age-related variability. After adjusting for confounders and propensity score, noninvasive positive pressure ventilation (odds ratio [OR], 0.19; 95% confidence interval [CI], 0.13-0.27), bilevel positive airway pressure (OR, 0.42; 95% CI, 0.39-0.45), and continuous positive airway pressure (OR, 0.70; 95% CI, 0.67-0.72) were individually associated with lower hospitalization risk in the 6 months post-treatment when compared with the 6 months pretreatment but not when compared with the baseline period between 12 and 6 months before treatment initiation. Stratified analysis suggests that comorbid sleep-disordered breathing, chronic respiratory failure, heart failure, and age less than 65 years were associated with greater benefits from positive airway pressure therapy.
  
  
  
  Initiation of positive airway pressure therapy was associated with reduction in hospitalization among patients with chronic obstructive pulmonary disease, but the causality needs to be determined by randomized controlled trials.
authors.affiliation: Arizona Respiratory Center, University of Arizona, Tucson.
authors.forename: Monica M
authors.initials: MM
authors.lastname: Vasquez
authors.affiliation: Dornsife School of Public Health, Drexel University, Philadelphia, Pa.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: McClure
authors.affiliation: Arizona Respiratory Center, University of Arizona, Tucson.
authors.forename: Duane L
authors.initials: DL
authors.lastname: Sherrill
authors.affiliation: Department of Medicine, University of Pittsburgh, Pa.
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Patel
authors.affiliation: Office of Health Affairs at the University of Illinois Hospital & Health Sciences System, Chicago.
authors.forename: Jerry
authors.initials: J
authors.lastname: Krishnan
authors.affiliation: Arizona Respiratory Center, University of Arizona, Tucson; Department of Medicine, University of Arizona, Tucson; CREAL Centre and Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Stefano
authors.initials: S
authors.lastname: Guerra
authors.affiliation: Department of Medicine, University of Arizona, Tucson; UAHS Center for Sleep & Circadian Sciences, University of Arizona, Tucson. Electronic address: Spartha1@email.arizona.edu.
authors.forename: Sairam
authors.initials: S
authors.lastname: Parthasarathy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D045422:Continuous Positive Airway Pressure; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000628:therapy*; D012131:Respiratory Insufficiency / Q000150:complications / Q000628:therapy; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000628:therapy; D055815:Young Adult
keywords: Artificial respiration; Chronic obstructive pulmonary disease; Continuous positive airway pressure; Hospitalization; Positive airway pressure therapy; Sleep; Sleep apnea; Sleep-disordered breathing