title: Synthesis and solution stability of water-soluble κ2N,κO-bis(3,5-dimethylpyrazolyl)ethanol manganese(i) tricarbonyl bromide (CORM-ONN1).
abstract: The reaction of (OC)5MnBr with bis(3,5-dimethyl-1-pyrazolyl)methane yields [{(PzMe2)2CH2}Mn(CO)3Br] (1). The use of tridentate heteroscorpionates such as bis(3,5-dimethyl-1-pyrazolyl)acetic acid and 2,2-bis(3,5-dimethyl-1-pyrazolyl)ethanol leads to the formation of mononuclear [(OC)3Mn{(PzMe2)2CH-CO2}] (2) and [(OC)3Mn{(PzMe2)2CH-CH2OH}]Br (3, CORM-ONN1). Salt-like photoCORM 3 is soluble in aqueous media up to a concentration of 200 μM, non-toxic up to an approx. 65 μM solution and releases all carbonyl ligands upon irradiation. The molecular complexes 1 and 2 are insoluble in aqueous solutions. CORM-ONN1 (3) slowly degrades in methanol yielding iCORM 4, consisting of the complex cation [{(PzMe2)2CH-CH2OH}{(PzMe2)2CH-CH2O}Mn]+and the [Mn(CO)5]-counter anion with the cations linked to a dimeric unit by intermolecular hydrogen bridges between the alcohol and alkoxide functionalities.
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University (FSU), Humboldstraße 8, D-07743 Jena, Germany. m.we@uni-jena.de.
authors.forename: Ralf
authors.initials: R
authors.lastname: Mede
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University (FSU), Humboldstraße 8, D-07743 Jena, Germany. m.we@uni-jena.de.
authors.forename: Juliane
authors.initials: J
authors.lastname: Traber
authors.affiliation: Institute of Physical Chemistry, Friedrich Schiller University Jena, Helmholtzweg 4, D-07743 Jena, Germany and Leibniz Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, D-07745 Jena, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Klein
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University (FSU), Humboldstraße 8, D-07743 Jena, Germany. m.we@uni-jena.de.
authors.forename: Helmar
authors.initials: H
authors.lastname: Görls
authors.affiliation: Center for Molecular Biomedicine (CMB), Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Straße 2, D-07745 Jena, Germany.
authors.forename: Guido
authors.initials: G
authors.lastname: Gessner
authors.affiliation: Leibniz Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, D-07745 Jena, Germany and Center for Sepsis Control and Care (CSCC), Jena University Hospital, Am Klinikum 1, D-07747 Jena, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hoffmann
authors.affiliation: Institute of Physical Chemistry, Friedrich Schiller University Jena, Helmholtzweg 4, D-07743 Jena, Germany and Leibniz Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, D-07745 Jena, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Schmitt
authors.affiliation: Institute of Physical Chemistry, Friedrich Schiller University Jena, Helmholtzweg 4, D-07743 Jena, Germany and Leibniz Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, D-07745 Jena, Germany and Center for Sepsis Control and Care (CSCC), Jena University Hospital, Am Klinikum 1, D-07747 Jena, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Popp
authors.affiliation: Center for Molecular Biomedicine (CMB), Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Straße 2, D-07745 Jena, Germany.
authors.forename: Stefan H
authors.initials: SH
authors.lastname: Heinemann
authors.affiliation: Institute of Physical Chemistry, Friedrich Schiller University Jena, Helmholtzweg 4, D-07743 Jena, Germany and Leibniz Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, D-07745 Jena, Germany and Center for Sepsis Control and Care (CSCC), Jena University Hospital, Am Klinikum 1, D-07747 Jena, Germany.
authors.forename: Ute
authors.initials: U
authors.lastname: Neugebauer
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University (FSU), Humboldstraße 8, D-07743 Jena, Germany. m.we@uni-jena.de.
authors.forename: Matthias
authors.identifier: http://orcid.org/0000-0002-1520-2401
authors.initials: M
authors.lastname: Westerhausen