title: Comprehensive preclinical evaluation of a multi-physics model of liver tumor radiofrequency ablation.
abstract: OBJECTIVE
  We aim at developing a framework for the validation of a subject-specific multi-physics model of liver tumor radiofrequency ablation (RFA).
  
  
  METHODS
  The RFA computation becomes subject specific after several levels of personalization: geometrical and biophysical (hemodynamics, heat transfer and an extended cellular necrosis model). We present a comprehensive experimental setup combining multimodal, pre- and postoperative anatomical and functional images, as well as the interventional monitoring of intra-operative signals: the temperature and delivered power.
  
  
  RESULTS
  To exploit this dataset, an efficient processing pipeline is introduced, which copes with image noise, variable resolution and anisotropy. The validation study includes twelve ablations from five healthy pig livers: a mean point-to-mesh error between predicted and actual ablation extent of 5.3 ± 3.6 mm is achieved.
  
  
  CONCLUSIONS
  This enables an end-to-end preclinical validation framework that considers the available dataset.
authors.affiliation: Université Côte d'Azur and Inria Sophia-Antipolis Méditerranée Asclepios team, Inria Sophia Antipolis, France. chloe.audigier@inria.fr.|Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA. chloe.audigier@inria.fr.
authors.forename: Chloé
authors.identifier: http://orcid.org/0000-0002-8443-1873
authors.initials: C
authors.lastname: Audigier
authors.affiliation: Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Mansi
authors.affiliation: Université Côte d'Azur and Inria Sophia-Antipolis Méditerranée Asclepios team, Inria Sophia Antipolis, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Delingette
authors.affiliation: Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA.
authors.forename: Saikiran
authors.initials: S
authors.lastname: Rapaka
authors.affiliation: Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA.
authors.forename: Tiziano
authors.initials: T
authors.lastname: Passerini
authors.affiliation: Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA.
authors.forename: Viorel
authors.initials: V
authors.lastname: Mihalef
authors.affiliation: Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Jolly
authors.affiliation: IHU - Institut de Chirugie Guidée Par L'Image, Strasbourg, France.
authors.forename: Raoul
authors.initials: R
authors.lastname: Pop
authors.affiliation: IHU - Institut de Chirugie Guidée Par L'Image, Strasbourg, France.
authors.forename: Michele
authors.initials: M
authors.lastname: Diana
authors.affiliation: IHU - Institut de Chirugie Guidée Par L'Image, Strasbourg, France.|IRCAD - Institut de Recherche Contre Les Cancers de L'Appareil Digestif, Strasbourg, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Soler
authors.affiliation: Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Kamen
authors.affiliation: Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA.
authors.forename: Dorin
authors.initials: D
authors.lastname: Comaniciu
authors.affiliation: Université Côte d'Azur and Inria Sophia-Antipolis Méditerranée Asclepios team, Inria Sophia Antipolis, France.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ayache
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D006439:Hemodynamics; D008099:Liver / Q000601:surgery*; D008113:Liver Neoplasms / Q000601:surgery*; D023421:Models, Animal; D009336:Necrosis / Q000601:surgery; D013552:Swine
keywords: Computational modeling; Preclinical evaluation; Radiofrequency ablation