title: Five cases of acute Zika virus infection in French women of reproductive age returning from Central and South America.
abstract: BACKGROUND
  The favorable season for Aedes albopictus circulation has started in Europe and may lead to autochthonous transmission of Zika virus. Health care providers should be familiar with evocative clinical presentations and able to give updated information to women of reproductive age infected by Zika virus.
  
  
  METHODS
  We report five laboratory-confirmed Zika virus infections imported to metropolitan France from Central and South America between January and April, 2016. The five young women were not connected and not pregnant; common presentation combined a rash with persistent arthralgia. Zika virus was identified by RT-PCR from serum or urines, between two and eight days after the onset of the symptoms.
  
  
  CONCLUSIONS
  As the duration of potential materno-foetal infectivity is still unknown, we were unable to answer with certitude to the patients' questions about the time interval to respect before attempting a pregnancy: one of them became pregnant one month after the diagnosis.
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: pauline.penot@aphp.fr.
authors.forename: P
authors.initials: P
authors.lastname: Penot
authors.affiliation: Service de bactériologie, virologie, hygiène, hôpital Avicenne, 93000 Bobigny, France.
authors.forename: S
authors.initials: S
authors.lastname: Balavoine
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Leplatois
authors.affiliation: Service de bactériologie, virologie, hygiène, hôpital Avicenne, 93000 Bobigny, France.
authors.forename: S
authors.initials: S
authors.lastname: Brichler
authors.affiliation: Centre national de référence des arbovirus, hôpital d'instruction des armées Laveran, 13384 Marseille cedex 13, France.
authors.forename: I
authors.initials: I
authors.lastname: Leparc-Goffart
authors.affiliation: Service de bactériologie, virologie, hygiène, hôpital Avicenne, 93000 Bobigny, France.
authors.forename: A-C
authors.initials: AC
authors.lastname: Alloui
authors.affiliation: Centre national de référence des arbovirus, hôpital d'instruction des armées Laveran, 13384 Marseille cedex 13, France.
authors.forename: O
authors.initials: O
authors.lastname: Flusin
authors.affiliation: Centre de planification familiale, hôpital Saint-Louis, 75010 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Guilleminot
authors.affiliation: Centre de planification familiale, hôpital Saint-Louis, 75010 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Amellou
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Molina
mesh_terms: D000208:Acute Disease; D000328:Adult; D002489:Central America; D005076:Exanthema / Q000175:diagnosis* / Q000821:virology; D005260:Female; D005602:France; D006801:Humans; D016133:Polymerase Chain Reaction; D060728:Reproductive Health; D013020:South America; D014195:Travel; D000071244:Zika Virus / Q000235:genetics / Q000302:isolation & purification; D000071243:Zika Virus Infection / Q000175:diagnosis* / Q000635:transmission / Q000821:virology
keywords: Imported viral disease; Mother to child transmission; Sexually transmitted infections; Vector-borne infections; Zika virus