title: Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans.
abstract: Bariatric surgery has been associated with bone remodeling changes. The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes.
  
  
  
  This study aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers after Roux-en-Y gastric bypass (RYGB). Anthropometric data, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BSAP), collagen type 1 C-telopeptide (CTX), 25-hydroxy vitamin D (25-OH-VitD), leptin, adiponectin, RANKL, OPG, and sclerostin of 30 menstruating women were measured preoperatively (Pre), and 3, 12, and 24 months (m) after RYGB.
  
  
  
  Leptin (34.4 (14.7; 51.9) vs. 22.5 (1.9; 52.7) ng/mL) and OPG (3.6 (1.1; 11.5) vs. 3.4 (1.5; 6) pmol/L) decreased, and adiponectin (7.4 (1.7; 18.4) vs. 13.8 (3.0; 34.6) μg/mL), CTX (0.2 (0.1; 2.2) vs. 0.6 (0.4; 6.0) ng/mL), RANKL (0.1 (0.0; 0.5) vs. 0.3 (0.0; 2.0) pmol/L), and sclerostin (21.7 (3.2; 75.1) vs. 34.8 (6.4; 80.5) pmol/L) increased after 3 m. BSAP increased after 12 m (10.1 (5.4; 18.9) vs. 13.9 (6.9; 30.2) μg/mL) (p < 0.005). CTX correlated positively with adiponectin at 24 m and inversely with leptin Pre; OPG at 3 m; weight, FM, FFM, and leptin at 24 m. RANKL correlated directly with weight at 3 m. Sclerostin correlated inversely with weight Pre and FM at 3 m. BSAP correlated negatively with 25-OH-VitD at 12 m, and positively with PTH at 24 m.
  
  
  
  RYGB induced weight loss, and biochemical, hormonal, and body composition changes are associated with higher bone remodeling.
authors.affiliation: Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil. mafebiagioni@yahoo.com.br.|Internal Medicine Department, Botucatu Medical School, São Paulo State University, FMB-Unesp, Rubião Júnior District, no number, Botucatu, SP, 18618-970, Brazil. mafebiagioni@yahoo.com.br.
authors.forename: Maria Fernanda G
authors.initials: MFG
authors.lastname: Biagioni
authors.affiliation: Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
authors.forename: Adriana L
authors.initials: AL
authors.lastname: Mendes
authors.affiliation: Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
authors.forename: Célia Regina
authors.initials: CR
authors.lastname: Nogueira
authors.affiliation: Surgery Department (CVL), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
authors.forename: Celso V
authors.initials: CV
authors.lastname: Leite
authors.affiliation: Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
authors.forename: Loraine
authors.initials: L
authors.lastname: Gollino
authors.affiliation: Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
authors.forename: Gláucia Mfs
authors.initials: GM
authors.lastname: Mazeto
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D017667:Adipocytes / Q000378:metabolism*; D054392:Adipokines / Q000097:blood / Q000378:metabolism*; D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis* / Q000097:blood; D016723:Bone Remodeling / Q000502:physiology*; D005260:Female; D015390:Gastric Bypass; D005819:Genetic Markers; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism / Q000601:surgery*; D053244:Osteoprotegerin / Q000096:biosynthesis* / Q000097:blood; D011446:Prospective Studies; D053245:RANK Ligand / Q000096:biosynthesis* / Q000097:blood; D015431:Weight Loss / Q000502:physiology; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D054392:Adipokines; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; D053244:Osteoprotegerin; D053245:RANK Ligand; C422903:SOST protein, human; C506030:TNFRSF11B protein, human
keywords: Bariatric surgery; Biomarkers; Bone remodeling; Cytokines; Wnt/β-catenin/LRPs