title: The elucidation of non-classical MHC class II antigen processing through the study of viral antigens.
abstract: By convention, CD4+T cells are activated predominantly by Major Histocompatibility Complex class II-bound peptides derived from extracellular (exogenous) antigens. It has been known for decades that alternative sources of antigen, particularly those synthesized within the antigen-presenting cell, can also supply peptides but the impact on TCD4+responses, sometimes considerable, has only recently become appreciated. This review focuses on the contributions that studies of viral antigen have made to this shift in perspective, concluding with discussions of relevance to rational vaccine design, autoimmunity and cancer immunotherapy.
authors.affiliation: Department of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia Research Institute and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States.
authors.forename: Asha Purnima
authors.initials: AP
authors.lastname: Veerappan Ganesan
authors.affiliation: Department of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia Research Institute and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States. Electronic address: eisenlc@mail.med.upenn.edu.
authors.forename: Laurence C
authors.initials: LC
authors.lastname: Eisenlohr
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000956:Antigens, Viral / Q000276:immunology* / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans
chemical_list: D000956:Antigens, Viral; D000949:Histocompatibility Antigens Class II