title: Neurochemical and metabolic effects of acute and chronic alcohol in the human brain: Studies with positron emission tomography.
abstract: The use of Positron emission tomography (PET) to study the effects of acute and chronic alcohol on the human brain has enhanced our understanding of the mechanisms underlying alcohol's rewarding effects, the neuroadaptations from chronic exposure that contribute to tolerance and withdrawal, and the changes in fronto-striatal circuits that lead to loss of control and enhanced motivation to drink that characterize alcohol use disorders (AUD). These include studies showing that alcohol's reinforcing effects may result not only from its enhancement of dopaminergic, GABAergic and opioid signaling but also from its caloric properties. Studies in those suffering from an AUD have revealed significant alterations in dopamine (DA), GABA, cannabinoids, opioid and serotonin neurotransmission and in brain energy utilization (glucose and acetate metabolism) that are likely to contribute to compulsive alcohol taking, dysphoria/depression, and to alcohol-associated neurotoxicity. Studies have also evaluated the effects of abstinence on recovery of brain metabolism and neurotransmitter function and the potential value of some of these measures to predict clinical outcomes. Finally, PET studies have started to provide insights about the neuronal mechanisms by which certain genes contribute to the vulnerability to AUD. These findings have helped identify new strategies for prevention and treatment of AUD. This article is part of the Special Issue entitled "Alcoholism".
authors.affiliation: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States; National Institute on Alcohol Abuse and Alcoholism, Laboratory of Neuroimaging, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: nvolkow@nida.nih.gov.
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
authors.affiliation: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Corinde E
authors.initials: CE
authors.lastname: Wiers
authors.affiliation: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Shokri-Kojori
authors.affiliation: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Dardo
authors.initials: D
authors.lastname: Tomasi
authors.affiliation: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Gene-Jack
authors.initials: GJ
authors.lastname: Wang
authors.affiliation: National Institute on Alcohol Abuse and Alcoholism, Laboratory of Neuroimaging, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Ruben
authors.initials: R
authors.lastname: Baler
mesh_terms: D000437:Alcoholism / Q000000981:diagnostic imaging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D063388:Endocannabinoids / Q000378:metabolism; D006801:Humans; D049268:Positron-Emission Tomography; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D063388:Endocannabinoids; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine
keywords: Alcoholism; Brain imaging; Brain metabolism; Dopamine D2 receptors; Frontal activity; Striatum