title: Synthesis of 2,2,2,-Trichloroethyl Aryl- and Vinyldiazoacetates by Palladium-Catalyzed Cross-Coupling.
abstract: An efficient and convenient synthesis of 2,2,2-trichloroethyl (TCE) aryl- and vinyldiazoacetates was achieved by palladium-catalyzed cross-coupling reactions between TCE diazoacetates and aryl or vinyl iodides. The broad substrate scope allows for rapid and facile formation of TCE aryl- and vinyldiazoacetates, which recently have emerged as versatile reagents for rhodium-carbene chemistry.
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, 30322, USA.
authors.forename: Liangbing
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, 30322, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Mighion
authors.affiliation: Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois, 60064, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Voight
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, 30322, USA.
authors.forename: Huw M L
authors.identifier: http://orcid.org/0000-0001-6254-9398
authors.initials: HM
authors.lastname: Davies
keywords: asymmetric cyclopropanation; cross-coupling; diazoacetates; donor/acceptor carbenes; palladium