title: Lack of effects of an equine chorionic gonadotropin (eCG) administration between days 9 and 15 postpartum on reproductive performance in a Holstein dairy herd.
abstract: Recently, it has been demonstrated that administration of equine chorionic gonadotropin (eCG) in the postpartum period in dairy cows can enhance follicle growth, reduce the interval from calving to first ovulation and increase plasma estradiol concentrations, and, thus, could enhance reproductive performance in a dairy herd when administered on day 6 postpartum. The aim of this study was to investigate the effects of a single dose of eCG between days 9 and 15 postpartum on parameters of reproductive performance in dairy cows. German Holstein cows (n = 1937; primiparous cows: n = 748; pluriparous cows: n = 1189) in a commercial dairy farm were randomly assigned to three experimental groups. Animals within the group eCG received a single dose of 600 IU eCG intramuscularly (i.m.) between days 9 and 15 postpartum followed by an i.m. administration of 500 μg cloprostenol after 14 days. Those of treatment group PG received cloprostenol only between days 23 and 29 postpartum. Cows of the control group remained untreated. Starting on day 49 postpartum, cows were subjected to a Presynch-Ovsynch protocol and inseminated artificially. The impact of application time (days postpartum) of eCG on the intervals calving to first service and calving to conception was statistically not significant. Outcomes of reproductive performance (i.e. first service conception rate, proportion of pregnant cows until 100 and 150 days in milk [DIM], number of inseminations until 150 DIM, calving to first service interval and calving to conception interval) did not differ significantly between treatment group eCG and group PG compared to control group. Regarding postpartum eCG administration, significant interactions between treatment and parity, season, milk yield, and early puerperal disorders, respectively, could not be shown. In conclusion, an eCG treatment of dairy cows between days 9 and 15 postpartum to increase reproductive performance cannot be recommended under the given circumstances.
authors.affiliation: Veterinary Practice Zettlitz, Zettlitz, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Freick
authors.affiliation: Veterinary Practice Zettlitz, Zettlitz, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Passarge
authors.affiliation: Veterinary Practice Zettlitz, Zettlitz, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Weber
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D003008:Cloprostenol / Q000008:administration & dosage / Q000494:pharmacology; D003612:Dairying; D005260:Female; D005298:Fertility / Q000187:drug effects; D006064:Gonadotropins, Equine / Q000008:administration & dosage / Q000494:pharmacology*; D007315:Insemination, Artificial / Q000662:veterinary*; D007774:Lactation; D049590:Postpartum Period; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D006064:Gonadotropins, Equine; D003008:Cloprostenol
keywords: cattle; equine chorionic gonadotropin; fertility; metritis; prostaglandin; puerperium