title: In Vitro Gene Delivery with Large Porous Silicon Nanoparticles Fabricated Using Cost-Effective, Metal-Assisted Chemical Etching.
abstract: The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal-assisted stain-etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney (HEK293) cells is demonstrated, suggesting the possibility of using such material for targeted transfection and drug delivery.
authors.affiliation: Department of Biology, Texas Christian University, Fort Worth, TX, 76129, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Wareing
authors.affiliation: Department of Biology, Texas Christian University, Fort Worth, TX, 76129, USA.
authors.forename: Kyle
authors.initials: K
authors.lastname: Szymanski
authors.affiliation: Department of Biology, Texas Christian University, Fort Worth, TX, 76129, USA.
authors.forename: Giridhar R
authors.initials: GR
authors.lastname: Akkaraju
authors.affiliation: pSiMedica Ltd, Malvern Hills Science Park, Geraldine Road, Malvern, Worcestershire, WR14 3 SZ, UK.
authors.forename: Armando
authors.initials: A
authors.lastname: Loni
authors.affiliation: pSiMedica Ltd, Malvern Hills Science Park, Geraldine Road, Malvern, Worcestershire, WR14 3 SZ, UK.
authors.forename: Leigh T
authors.initials: LT
authors.lastname: Canham
authors.affiliation: Department of Chemistry, Texas Christian University, Fort Worth, TX, 76129, USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gonzalez-Rodriguez
authors.affiliation: Department of Chemistry, Texas Christian University, Fort Worth, TX, 76129, USA.
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Coffer
mesh_terms: D003362:Cost-Benefit Analysis; D016650:Fluorescein-5-isothiocyanate; D018014:Gene Transfer Techniques; D057809:HEK293 Cells; D006801:Humans; D008670:Metals / Q000737:chemistry*; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012825:Silicon / Q000737:chemistry*; D013010:Sonication
chemical_list: D008670:Metals; D016650:Fluorescein-5-isothiocyanate; D012825:Silicon
keywords: gene delivery; nanomedicine; porous silicon; stain etching; surface modification