title: Evaluation of epidemiological characteristics and risk factors affecting mortality in patients with candidemia.
abstract: OBJECTIVE
  The aim of this study was to determine epidemiologic characters of patients with candidemia and to evaluate risk factors that can affect mortality rates among these patients.
  
  
  METHODS
  Patients admitted to the İstanbul Medeniyet University Göztepe Training Hospital between 2009 and 2011 who had a positive blood culture for Candida spp. during hospitalization were studied retrospectively for demographic characteristics and risk factors. Statistical comparisons were estimated with the Stata 12 package. Independent variables associated with mortality were estimated by Cox regression analyses.
  
  
  RESULTS
  A total of 89 patients were identified with a positive blood culture. Of the isolates, 72% (64/89) were C. albicans and 10% (9/89) were non-albicans Candida, while 18% (16/89) were unidentified. C. parapsilosis was the most frequently isolated species among non-albicans Candida. The crude mortality rate among candidemia cases was 30% (27/89). By univariate analysis, being in the ICU and age (≥50 or ≥60) were found to be statistically significant, whereas by multivariate analysis only age of ≥50 years was independently more associated with mortality (OR, 2.7; CI, 1.05-6.73).
  
  
  CONCLUSIONS
  Candidemia is associated with high mortality rates. Patients older than 50 years are found to be at considerable risk in terms of adverse outcomes.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Yılmaz Karadağ
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Ergen
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Aydın
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Doğru
authors.affiliation: Department of Microbiology and Clinical Microbiology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Berrin
authors.initials: B
authors.lastname: Tanıdır
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Mustafa Haluk
authors.initials: MH
authors.lastname: Vahaboğlu
mesh_terms: D000935:Antifungal Agents; D002175:Candida; D058387:Candidemia; D006785:Hospitals, University; D006801:Humans; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents
keywords: Candidemia; epidemiology; mortality; risk factors