title: NMOSD triggered by yellow fever vaccination - An unusual clinical presentation with segmental painful erythema.
abstract: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an immune-mediated disease of the central nervous system with the presence of aquaporin 4-antibodies (AQP4-abs) in most cases. We describe a patient who developed NMOSD after a yellow fever vaccination. He presented to us with an unusual painful erythema Th7-9 triggered by touch in the respective skin area due to a cervical spinal cord lesion affecting the dorsolateral parts of C6/7. To our knowledge, this is the first case of NMOSD with such a clinical presentation expanding the clinical spectrum of NMOSD. It is important to be aware of that a yellow fever vaccination can trigger NMOSD.
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University, Munich, Germany; German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University, Munich, Germany. Electronic address: Florian.Schoeberl@med.uni-muenchen.de.
authors.forename: F
authors.initials: F
authors.lastname: Schöberl
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University, Munich, Germany. Electronic address: Endy.Csanadi@med.uni-muenchen.de.
authors.forename: E
authors.initials: E
authors.lastname: Csanadi
authors.affiliation: German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University, Munich, Germany. Electronic address: Ozan.Eren@med.uni-muenchen.de.
authors.forename: O
authors.initials: O
authors.lastname: Eren
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University, Munich, Germany; German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University, Munich, Germany; SyNergy, Munich Cluster for Systems Neurology, Munich, Germany. Electronic address: Marianne.Dieterich@med.uni-muenchen.de.
authors.forename: M
authors.initials: M
authors.lastname: Dieterich
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University, Munich, Germany; Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Munich, Germany. Electronic address: Tania.Kuempfel@med.uni-muenchen.de.
authors.forename: T
authors.initials: T
authors.lastname: Kümpfel
mesh_terms: D001933:Brain Stem / Q000000981:diagnostic imaging; D004890:Erythema / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D010146:Pain / Q000209:etiology; D012867:Skin / Q000473:pathology; D013116:Spinal Cord / Q000000981:diagnostic imaging; D014611:Vaccination / Q000009:adverse effects; D015004:Yellow Fever / Q000517:prevention & control*; D022341:Yellow Fever Vaccine / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D022341:Yellow Fever Vaccine
keywords: Devic's syndrome; NMOSD; Painful erythema; Transverse myelitis; Yellow fever vaccination