title: Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARγ, proinflammatory cytokines and oxidative stress.
abstract: Cinnamon has a history of use for medicinal purposes and its major benefits have been linked to cinnamaldehyde. The present study aimed to investigate the hypoglycemic action of cinnamaldehyde against fatty-sucrosed diet/streptozotocin (FSD/STZ)-rat model of gestational diabetes. Female albino rats were divided into three groups. Group I fed with normal diet (ND) while group II and III were fed with FSD for eight weeks (five weeks pre-gestational and three weeks gestational). Rats of group III were administered with a daily oral dose of 20mg/kg cinnamaldehyde one week before mating onward. At the 7th day of gestation, FSD-fed rats were injected intraperitoneally with STZ (25mg/kg b.wt.) to induce gestational diabetes. Pre-mating treatment of cinnamaldehyde controls hyperphagia and glucose intolerance during the gestational period than in diabetic rats. It also reduced levels of fructosamine, total cholesterols, triglycerides, leptin, tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA) and nitric oxide (NO), while it significantly increased levels of high-density lipoprotein (HDL)-cholesterol, adiponectin, liver glycogen, reduced glutathione (GSH) and catalase activity at term pregnancy. In addition, cinnamaldehyde administration up-regulated the mRNA expression of peroxisome proliferated activated receptor-gamma (PPARγ) and also ameliorated the number of viable fetuses, implantation loss sites, fetal glucose and insulin levels. In conclusion, cinnamaldehyde has safe hypoglycemic action on gestational diabetes by potentiating insulin secretion and sensitivity through activating the antioxidant defense system, suppressing pro-inflammatory cytokines production, upregulating PPARγ gene expression and alleviating the reproductive performance.
authors.affiliation: Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, 62511 Beni-Suef, Egypt.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Hosni
authors.affiliation: Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, 62511 Beni-Suef, Egypt. Electronic address: adel_men2020@yahoo.com.
authors.forename: A Adel
authors.initials: AA
authors.lastname: Abdel-Moneim
authors.affiliation: Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, 62511 Beni-Suef, Egypt.
authors.forename: Eman S
authors.initials: ES
authors.lastname: Abdel-Reheim
authors.affiliation: Biochemistry Department, Theodor Bilharz Research Institute, 12411 Giza, Egypt.
authors.forename: Samah M
authors.initials: SM
authors.lastname: Mohamed
authors.affiliation: Clinical Pathology Department, Faculty of Veterinary Medicine, Beni-Suef University, 62511 Beni-Suef, Egypt.
authors.forename: Hamdi
authors.initials: H
authors.lastname: Helmy
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000378:metabolism; D019270:Fructosamine / Q000097:blood; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008099:Liver / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D018836:Inflammation Mediators; D007328:Insulin; D020738:Leptin; D047495:PPAR gamma; D012333:RNA, Messenger; D014280:Triglycerides; D019270:Fructosamine; D000171:Acrolein; D006003:Glycogen; D002784:Cholesterol; C012843:cinnamaldehyde
keywords: Cinnamaldehyde; Cinnamomum zeylanicum; Gestational diabetes; Maternal outcome; Oxidative stress; Pro-inflammatory cytokines