title: Is the Assessment of 5 Meters of Gait with a Single Body-Fixed-Sensor Enough to Recognize Idiopathic Parkinson's Disease-Associated Gait?
abstract: Quantitative assessment of gait in patients with Parkinson's disease (PD) is an important step in addressing motor symptoms and improving clinical management. Based on the assessment of only 5 meters of gait with a single body-fixed-sensor placed on the lower back, this study presents a method for the identification of step-by-step kinematic parameters in 14 healthy controls and in 28 patients at early-to-moderate stages of idiopathic PD. Differences between groups in step-by-step kinematic parameters were evaluated to understand gait impairments in the PD group. Moreover, a discriminant model between groups was built from a subset of significant and independent parameters and based on a 10-fold cross-validated model. The discriminant model correctly classified a total of 89.5% participants with four kinematic parameters. The sensitivity of the model was 95.8% and the specificity 78.6%. The results indicate that the proposed method permitted to reasonably recognize idiopathic PD-associated gait from 5-m walking assessments. This motivates further investigation on the clinical utility of short episodes of gait assessment with body-fixed-sensors.
authors.affiliation: MOVE Research Institute Amsterdam, Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. m.e.micoamigo@vu.nl.|McRoberts B.V., Raamweg 43, 2596 HN, The Hague, The Netherlands. m.e.micoamigo@vu.nl.
authors.forename: M E
authors.initials: ME
authors.lastname: Micó-Amigo
authors.affiliation: MOVE Research Institute Amsterdam, Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: Kingma
authors.affiliation: MOVE Research Institute Amsterdam, Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
authors.forename: G S
authors.initials: GS
authors.lastname: Faber
authors.affiliation: McRoberts B.V., Raamweg 43, 2596 HN, The Hague, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Kunikoshi
authors.affiliation: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tübingen, Tübingen, Germany.|DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany.
authors.forename: J M T
authors.initials: JMT
authors.lastname: van Uem
authors.affiliation: MOVE Research Institute Amsterdam, Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.|McRoberts B.V., Raamweg 43, 2596 HN, The Hague, The Netherlands.
authors.forename: R C
authors.initials: RC
authors.lastname: van Lummel
authors.affiliation: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tübingen, Tübingen, Germany.|DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Maetzler
authors.affiliation: MOVE Research Institute Amsterdam, Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: van Dieën
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*
keywords: Accelerometers; Gyroscopes; Short gait episodes; Step-by-step gait analysis