title: MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and adrenocortical tumors?
abstract: Sporadic tumors of the pituitary, parathyroids and adrenal cortex are unique, as their benign forms are very common, but malignant forms are exceptionally rare. Hereditary forms of these tumors occur in multiple endocrine neoplasia syndrome type 1 (MEN1). We hypothesize that the pathogenic link among the sporadic tumors of these organs of different germ layers might be represented by common molecular pathways involving the MEN1 gene and microRNAs (miR). miR-24 might be a microRNA linking the three tumor entities, but other candidates such as miR-142-3p and microRNAs forming the DLK1-MEG3 miRNA cluster might also be of importance.
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Nagy
authors.affiliation: National Institutes of Health/NCI/DCTD/BRP, 9609 Medical Center Dr Bethesda MD, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Szabó
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary; "Lendület-2013" Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary.
authors.forename: V K
authors.initials: VK
authors.lastname: Grolmusz
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Perge
authors.affiliation: Department of Gastroenterology, Szt Imre Teaching Hospital Budapest, Budapest, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Igaz
authors.affiliation: "Lendület-2013" Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary; Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Patócs
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary. Electronic address: igaz.peter@med.semmelweis-univ.hu.
authors.forename: P
authors.initials: P
authors.lastname: Igaz
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000235:genetics*; D002135:Calcium-Binding Proteins; D002471:Cell Transformation, Neoplastic; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics*; D008962:Models, Theoretical; D005810:Multigene Family; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics*; D009154:Mutation; D010282:Parathyroid Neoplasms / Q000235:genetics*; D010902:Pituitary Gland / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics; D051900:Smad3 Protein / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; C498907:MEG3 non-coding RNA, human; C105373:MEN1 protein, human; C555159:MIRN142 microRNA, human; C543845:MIRN24 microRNA, human; D008565:Membrane Proteins; D035683:MicroRNAs; D011518:Proto-Oncogene Proteins; D062085:RNA, Long Noncoding; C497790:SMAD3 protein, human; D051900:Smad3 Protein; D016212:Transforming Growth Factor beta
keywords: Adrenal cortex; MEN1; MicroRNA; Parathyroid; Pituitary; Tumor