title: Genome scan linkage analysis identifies a major quantitative trait loci for fatty acid composition inlongissimus dorsimuscle in an F2intercross between Landrace and Korean native pigs.
abstract: OBJECTIVE
  This study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large F2intercross between Landrace and Korean native pigs.
  
  
  METHODS
  Eighteen FA composition traits were measured in more than 960 F2progeny. All experimental animals were genotyped with 165 microsatellite markers located throughout the pig autosomes.
  
  
  RESULTS
  We detected 112 QTLs for the FA composition; Forty seven QTLs reached the genome-wide significant threshold. In particular, we identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid on pig chromosome 12 (F-value = 97.2 under additive and dominance model, nominal p-value 3.6×10-39) accounted for 16.9% of phenotypic variance. In addition, four more QTLs for C18:1, C18:2, C20:4, and monounsaturated fatty acids on the similar position explained more than 10% of phenotypic variance.
  
  
  CONCLUSIONS
  Our findings of a major QTL for FA composition presented here could provide helpful information to locate causative variants to improve meat quality traits in pigs.
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.
authors.forename: Hee-Bok
authors.initials: HB
authors.lastname: Park
authors.affiliation: Educational Science Research Institute, Jeju National University, Jeju 63243, Korea.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Han
authors.affiliation: Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 52828, Korea.
authors.forename: Chae-Kyoung
authors.initials: CK
authors.lastname: Yoo
authors.affiliation: Korea Zoonosis Research Institute, Chonbuk National University, Iksan 54531, Korea.
authors.forename: Jae-Bong
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.
authors.forename: Ji-Hyang
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Baek
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.
authors.forename: Jun-Kyu
authors.initials: JK
authors.lastname: Son
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.
authors.forename: Sang-Min
authors.initials: SM
authors.lastname: Shin
authors.affiliation: Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 52828, Korea.|Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju 52828, Korea.
authors.forename: Hyun-Tae
authors.initials: HT
authors.lastname: Lim
authors.affiliation: Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration, Jeju 63242, Korea.
authors.forename: In-Cheol
authors.initials: IC
authors.lastname: Cho
keywords: Fatty Acid; Genome-wide Linkage Analysis; Korean Native Pigs; Landrace; Quantitative Trait Locus