title: The intriguing role of soluble urokinase receptor in inflammatory diseases.
abstract: Inflammation is a key player in the development of an increasing amount of diseases. The soluble urokinase plasminogen activator receptor (suPAR) is a highly flexible molecule with intrinsic chemotactic properties. This glycoprotein has been evaluated as a biomarker of inflammation, immune activation, organ damage and clinical outcome in several pathologies, including cardiovascular disease, hepatitis, renal disorders and rheumatic pathologies. The use of this early warning inflammatory biomarker could potentially improve the prediction of the severity of these diseases and mortality. In the present paper, we describe the general characteristics of suPAR and its intriguing role as a biomarker in different inflammatory diseases.
authors.affiliation: a Department of Nephrology and.
authors.forename: S
authors.initials: S
authors.lastname: Desmedt
authors.affiliation: a Department of Nephrology and.
authors.forename: V
authors.initials: V
authors.lastname: Desmedt
authors.affiliation: b Department of Clinical Chemistry , Ghent University Hospital , Gent , Belgium.
authors.forename: J R
authors.initials: JR
authors.lastname: Delanghe
authors.affiliation: b Department of Clinical Chemistry , Ghent University Hospital , Gent , Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Speeckaert
authors.affiliation: a Department of Nephrology and.
authors.forename: M M
authors.initials: MM
authors.lastname: Speeckaert
mesh_terms: D000818:Animals; D015415:Biomarkers; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007249:Inflammation; D051379:Mice; D018448:Models, Immunological; D055293:Receptors, Urokinase Plasminogen Activator
chemical_list: D015415:Biomarkers; D055293:Receptors, Urokinase Plasminogen Activator
keywords: Biomarker; chemotaxis; immune activation; inflammation; soluble urokinase plasminogen activator receptor