title: Neuropsychological outcome following frontal lobectomy for pharmacoresistant epilepsy in adults.
abstract: OBJECTIVE
  This retrospective cohort study characterized cognitive and motor outcomes in a large sample of adults who underwent frontal lobe resections for treatment of pharmacoresistant epilepsy.
  
  
  METHODS
  Ninety patients who underwent unilateral frontal lobe resection for epilepsy (42 language-dominant hemisphere/48 nondominant hemisphere) between 1989 and 2014 completed comprehensive preoperative and postoperative neuropsychological evaluations that included measures of verbal and nonverbal intellectual functioning, attention/working memory, processing speed, language, executive functioning, verbal and visual memory, and motor functioning. Objective methods were used to assess meaningful change across a wide range of abilities and to identify factors associated with neuropsychological decline following frontal lobectomy. Detailed postoperative neuroimaging analysis was conducted to characterize region, extent, and volume of resection.
  
  
  RESULTS
  Forty-eight percent of patients did not demonstrate meaningful postoperative declines in cognition and an additional 42% demonstrated decline in 1 or 2 cognitive domains. When cognitive decline was observed, it usually occurred on measures of intelligence, visuomotor processing speed, or executive functioning. Side and site of resection were unrelated to cognitive outcome, but played a role in decline of contralateral manual dexterity following supplementary motor area resection. Higher preoperative ability, older age at surgery, absence of a malformation of cortical development on MRI, and poor seizure outcome were related to cognitive decline on some measures, but had poor sensitivity in identifying at-risk patients.
  
  
  CONCLUSIONS
  The vast majority of patients who undergo frontal lobectomy for treatment of pharmacoresistant epilepsy demonstrate good cognitive and motor outcomes.
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH. buschr@ccf.org.
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Busch
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: Darlene P
authors.initials: DP
authors.lastname: Floden
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: Lisa
authors.initials: L
authors.lastname: Ferguson
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: Shamseldeen
authors.initials: S
authors.lastname: Mahmoud
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: Audrina
authors.initials: A
authors.lastname: Mullane
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: Stephen
authors.initials: S
authors.lastname: Jones
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: Lara
authors.initials: L
authors.lastname: Jehi
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: William
authors.initials: W
authors.lastname: Bingaman
authors.affiliation: From the Epilepsy Center (R.M.B., L.F., S.J., L.J., W.B., I.M.N.), Psychiatry & Psychology (R.M.B., D.P.F., L.F., A.M.), Center for Neurological Restoration (D.P.F.), and Diagnostic Radiology (S.M., S.J.), Neurological Institute, Cleveland Clinic, OH.
authors.forename: Imad M
authors.initials: IM
authors.lastname: Najm
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition; D000069279:Drug Resistant Epilepsy / Q000523:psychology* / Q000601:surgery*; D005260:Female; D005625:Frontal Lobe / Q000601:surgery*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000009:adverse effects; D011184:Postoperative Period; D057234:Preoperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult