title: A Case Report of Successful Kidney Donation After Brain Death Following Nicotine Intoxication.
abstract: Nicotine intoxication is a rare cause of death and can lead to brain death after respiratory arrest and hypoxic-ischemic encephalopathy. To our knowledge, no previous reports regarding organ donation after nicotine intoxication have been described. We present a successful case of kidney donation after brain death caused by subcutaneous nicotine overdose from liquid nicotine from an e-cigarette cartridge in an attempted suicide. Both kidneys were transplanted successfully with immediate graft function, and both recipients were discharged at postoperative day 9 with normal plasma creatinine levels. Graft function has remained excellent in follow-up. This case suggests that kidneys from a donor with fatal nicotine intoxication may be successfully used for kidney transplantation in the absence of other contraindications for donation.
authors.affiliation: Department of Transplant and Liver Surgery, Helsinki University Hospital, Helsinki, Finland. Electronic address: minna.rasanen@hus.fi.
authors.forename: M
authors.initials: M
authors.lastname: Räsänen
authors.affiliation: Department of Transplant and Liver Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: I
authors.initials: I
authors.lastname: Helanterä
authors.affiliation: Department of Anesthesiology and Intensive Care Unit, Tampere University Hospital, Tampere, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kalliomäki
authors.affiliation: Department of Transplant and Liver Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Savikko
authors.affiliation: Poison Information Centre, Department of Emergency Medicine, Helsinki University Hospital, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Parry
authors.affiliation: Department of Transplant and Liver Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Lempinen
mesh_terms: D000328:Adult; D001926:Brain Death; D046148:Donor Selection / Q000379:methods*; D062787:Drug Overdose / Q000209:etiology*; D066300:Electronic Nicotine Delivery Systems; D005260:Female; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D009392:Nephrectomy; D009538:Nicotine / Q000506:poisoning*; D018722:Nicotinic Agonists / Q000506:poisoning*; D020858:Tissue and Organ Harvesting / Q000379:methods; D009927:Tissue and Organ Procurement
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine