title: Low-Molecular-Weight Hydrophilic and Lipophilic Antioxidants in Nonmelanoma Skin Carcinomas and Adjacent Normal-Looking Skin.
abstract: Low-molecular-weight antioxidants are some of the most efficient agents of the skin defense mechanism against environmental factors, such as cosmic rays, smoke, and pollutants. The total skin concentrations of hydrophilic ascorbic and uric acids, as well as lipophilic α-tocopherol, β-carotene, and ubiquinol-10 antioxidants were determined by an HPLC-EC detector from 18 biopsies of human nonmelanoma skin carcinomas and 18 biopsies from skin areas adjacent to carcinomas. No significant differences in the concentrations of lipophilic antioxidants in both carcinomas and normal-looking skin areas adjacent to carcinomas were observed. On the contrary, ascorbic and uric acid concentrations were found to be 18 and 36% lower in carcinomas than in normal-looking skin areas, respectively. No statistical significance was observed between antioxidant concentrations and age, sex, phototype, profession, site of tumor, frequency, and time of UV light exposure either. Accordingly the antioxidant concentrations in both cancerous skin and adjacent normal-looking areas were found to be much higher than in normal skin, in contrast to literature data.
authors.affiliation: Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Grammenandi
authors.forename: Maria
authors.initials: M
authors.lastname: Kyriazi
authors.forename: Alexandra
authors.initials: A
authors.lastname: Katsarou-Katsari
authors.forename: Othon
authors.initials: O
authors.lastname: Papadopoulos
authors.forename: Ioanna
authors.initials: I
authors.lastname: Anastassopoulou
authors.forename: Georgios T
authors.initials: GT
authors.lastname: Papaioannou
authors.forename: Alexandros
authors.initials: A
authors.lastname: Sagriotis
authors.forename: Michail
authors.initials: M
authors.lastname: Rallis
authors.forename: Howard I
authors.initials: HI
authors.lastname: Maibach
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D001205:Ascorbic Acid / Q000737:chemistry / Q000378:metabolism*; D002280:Basal Cell Carcinoma / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D014527:Uric Acid / Q000737:chemistry / Q000378:metabolism*; D024502:alpha-Tocopherol / Q000737:chemistry / Q000378:metabolism*; D019207:beta Carotene / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D014451:Ubiquinone; D014527:Uric Acid; C026663:ubiquinol-10; D024502:alpha-Tocopherol; D001205:Ascorbic Acid