title: Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.
abstract: Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared with conventional NK cells. In this study, we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e-NK cells are tissue resident in the liver. Thus, these studies indicate that tissue-resident NK cells are evolutionarily conserved in humans and mice, providing a foundation to explore their role in human disease.
authors.affiliation: Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Han Xian
authors.initials: HX
authors.lastname: Aw Yeang
authors.affiliation: Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Sytse J
authors.identifier: 0000-0002-5379-3556
authors.initials: SJ
authors.lastname: Piersma
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Yiing
authors.identifier: 0000-0002-0317-7608
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.affiliation: Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Olga N
authors.initials: ON
authors.lastname: Malkova
authors.affiliation: Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Cathrine
authors.initials: C
authors.lastname: Miner
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110; and.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Krupnick
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: William C
authors.initials: WC
authors.lastname: Chapman
authors.affiliation: Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110; yokoyama@wustl.edu.|Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110.|Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Wayne M
authors.identifier: 0000-0002-0566-7264
authors.initials: WM
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D002196:Capillaries / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D039482:Integrin alpha5 / Q000235:genetics / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology*; D008099:Liver / Q000098:blood supply / Q000166:cytology* / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D014157:Transcription Factors
chemical_list: D039482:Integrin alpha5; D014157:Transcription Factors