title: Modes of Hypotensive Action of Dihydroquercetin in Arterial Hypertension.
abstract: We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change. In in vitro experiments, dihydroquercetin (10-8-10-6M) induced relaxation of the isolated thoracic aorta rings in a dose-dependent manner. Hence, the antihypertensive effect of dihydroquercetin results from the decrease in blood viscosity and vasodilation.
authors.affiliation: Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. mbp2001@mail.ru.
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.affiliation: Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.affiliation: Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sidekhmenova
authors.affiliation: Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Shamanaev
authors.affiliation: Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Anishchenko
authors.affiliation: Department of Biophysics and Functional Diagnostics, Siberian State Medical University, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Nosarev
authors.affiliation: Department of Biophysics and Functional Diagnostics, Siberian State Medical University, Tomsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Pushkina
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D065570:Gastric Absorption; D006352:Heart Ventricles / Q000187:drug effects* / Q000503:physiopathology; D006400:Hematocrit; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D046509:Tissue Culture Techniques; D014664:Vasodilation / Q000187:drug effects*; D014783:Viscosity / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D011794:Quercetin; C003377:taxifolin
keywords: SHR rats; arterial hypertension; dihydroquercetin; rheological indices; vascular tone of isolated preparation