title: CDK11p58 Promotes Microglia Activation via Inducing Cyclin D3 Nuclear Localization.
abstract: Microglia activation has been implicated in the pathogenesis of many neurological diseases. These reactive microglia are capable of producing a variety of proinflammatory mediators and potentially neurotoxic compounds. The increase of cell number and expression of CD11b are the main features of activated microglia. In this study, we examined the suppressive effects of CDK11p58 on microglia activation induced by lipopolysaccharide (LPS) in vitro. We found that in the activated microglia, the expression of CDK11p58 increased and the overexpression of CDK11p58 could reduce the increased proliferation and CD11b expression in LPS-activated microglia. Such suppressive effects might be resulted from the interaction with cyclin D3 which promoted CDK11p58 nuclear localization. Our results suggested that CDK11p58 acted to regulate microglia activation through CDK11p58 and cyclin D3 interaction.
authors.affiliation: Deapartment of Nursing, The second affiliated Hospital of Nantong University, Nantong, China. shenbiyu@126.com.|Department of Spine Surgery, The Second Affiliated Hospital of Nantong University, Nantong, China. shenbiyu@126.com.
authors.forename: Biyu
authors.initials: B
authors.lastname: Shen
authors.affiliation: Deapartment of Nursing, The second affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Gu
authors.affiliation: Deapartment of Nursing, The second affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Haoyang
authors.initials: H
authors.lastname: Chen
authors.affiliation: Deapartment of Nursing, The second affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Deapartment of Nursing, The second affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: Deapartment of Nursing, The second affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Deapartment of Nursing, The second affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Wengting
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of Spine Surgery, The Second Affiliated Hospital of Nantong University, Nantong, China. czmspine@163.coms.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Cui
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D039481:CD11b Antigen / Q000378:metabolism; D049109:Cell Proliferation; D002478:Cells, Cultured; D056743:Cyclin D3 / Q000032:analysis / Q000378:metabolism* / Q000502:physiology; D007165:Immunosuppression Therapy; D017628:Microglia / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D039481:CD11b Antigen; C534698:Ccnd3 protein, rat; D056743:Cyclin D3
keywords: CDK11p58; activation; cyclin D3; lipopolysaccharide; microglia