title: Synthetic Strategies for Peroxide Ring Construction in Artemisinin.
abstract: The present review summarizes publications on the artemisinin peroxide fragment synthesis from 1983 to 2016. The data are classified according to the structures of a precursor used in the key peroxidation step of artemisinin peroxide cycle synthesis. The first part of the review comprises the construction of artemisinin peroxide fragment in total syntheses, in which peroxide artemisinin ring resulted from reactions of unsaturated keto derivatives with singlet oxygen or ozone. In the second part, the methods of artemisinin synthesis based on transformations of dihydroartemisinic acid are highlighted.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, Moscow 119991, Russia. vil@ioc.ac.ru.|Faculty of Chemical and Pharmaceutical Technology and Biomedical Products, D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, Moscow 125047, Russia. vil@ioc.ac.ru.|All-Russian Research Institute for Phytopathology, 143050 B. Vyazyomy, Moscow Region, Russia. vil@ioc.ac.ru.
authors.forename: Vera A
authors.initials: VA
authors.lastname: Vil'
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, Moscow 119991, Russia. yaremenko@ioc.ac.ru.|Faculty of Chemical and Pharmaceutical Technology and Biomedical Products, D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, Moscow 125047, Russia. yaremenko@ioc.ac.ru.|All-Russian Research Institute for Phytopathology, 143050 B. Vyazyomy, Moscow Region, Russia. yaremenko@ioc.ac.ru.
authors.forename: Ivan A
authors.initials: IA
authors.lastname: Yaremenko
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, Moscow 119991, Russia. ilov@ioc.ac.ru.
authors.forename: Alexey I
authors.initials: AI
authors.lastname: Ilovaisky
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, Moscow 119991, Russia. alterex@yandex.ru.|Faculty of Chemical and Pharmaceutical Technology and Biomedical Products, D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, Moscow 125047, Russia. alterex@yandex.ru.|All-Russian Research Institute for Phytopathology, 143050 B. Vyazyomy, Moscow Region, Russia. alterex@yandex.ru.
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Terent'ev
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000266:history; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000266:history; D060326:Chemistry Techniques, Synthetic / Q000266:history / Q000379:methods*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010084:Oxidation-Reduction; D010126:Ozone / Q000737:chemistry; D010545:Peroxides / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D010545:Peroxides; C520462:dihydroartemisinic acid; D026082:Singlet Oxygen; D010126:Ozone
keywords: artemisinic acid; artemisinin; cycles; organic peroxide; peroxidation