title: Bioprospecting of antimicrobial activity of extracts of endophytic fungi from Bauhinia guianensis.
abstract: Antibiotic resistance results in higher medical costs, prolonged hospital stays and increased mortality and is rising to dangerously high levels in all parts of the world. Therefore, this study aims to search for new antimicrobial agents through bioprospecting of extracts of endophytic fungi from Bauhinia guianensis, a typical Amazonian plant used in combating infections. Seventeen (17) fungi were isolated and as result the methanolic extract of the fungus Exserohilum rostratum showed good activity against the bacteria tested. The polyketide monocerin was isolated by the chromatographic technique, identified by NMR and MS, showing broad antimicrobial spectrum.
authors.affiliation: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
authors.forename: Eduardo A A
authors.initials: EA
authors.lastname: Pinheiro
authors.affiliation: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
authors.forename: Jeferson R S
authors.initials: JR
authors.lastname: Pina
authors.affiliation: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
authors.forename: André O
authors.initials: AO
authors.lastname: Feitosa
authors.affiliation: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
authors.forename: Josiwander M
authors.initials: JM
authors.lastname: Carvalho
authors.affiliation: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
authors.forename: Fábio C
authors.initials: FC
authors.lastname: Borges
authors.affiliation: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
authors.forename: Patrícia S B
authors.initials: PS
authors.lastname: Marinho
authors.affiliation: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil. Electronic address: andrey@ufpa.br.
authors.forename: Andrey M R
authors.initials: AM
authors.lastname: Marinho
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D036481:Bauhinia; D065132:Bioprospecting; D007887:Fabaceae; D005658:Fungi; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents
keywords: Actividad antimicrobiana; Antimicrobial activity; Bauhinia guianensis; Endophytic fungi; Hongos endófitos; Monocerin