title: Ameloblastic carcinoma of the maxilla: A case report and an updated review of the literature.
abstract: Ameloblastic carcinoma (AC) is an uncommon malignant odontogenic tumor that can be difficult to differentiate from ameloblastoma and can arise directly as an undifferentiated lesion or from a pre-existing benign lesion. The current study presents a novel case of primary maxillary AC and review the literature on AC of the maxilla. The review of the literature indicates that secondary tumors and posterior localization are associated with a higher tendency for recurrence and, often, multiple recurrences. Surgical therapy, eventually followed by radiotherapy, is the treatment modality most frequently applied, while the role of chemotherapy remains unclear. Several new cases of maxillary AC have been recently described in literature, making this pathology more frequent than previously considered; this is perhaps an indication of an increased diagnostic sensibility, rather than a real increase in the incidence of the disease itself.
authors.affiliation: Maxillofacial Surgery Unit, Faculty of Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, I-00168 Rome.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Moro
authors.affiliation: Maxillofacial Surgery Unit, Faculty of Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, I-00168 Rome.
authors.forename: Enrico
authors.initials: E
authors.lastname: Foresta
authors.affiliation: Maxillofacial Surgery Unit, Faculty of Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, I-00168 Rome.
authors.forename: Giulio
authors.initials: G
authors.lastname: Gasparini
authors.affiliation: Maxillofacial Surgery Unit, Faculty of Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, I-00168 Rome.
authors.forename: Sandro
authors.initials: S
authors.lastname: Pelo
authors.affiliation: Maxillofacial Surgery Unit, Faculty of Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, I-00168 Rome.
authors.forename: Mario
authors.initials: M
authors.lastname: Forcione
authors.affiliation: Pathological Anatomy Service, Foligno Hospital, I-06034 Foligno, Italy.
authors.forename: Enrico Giuseppe
authors.initials: EG
authors.lastname: Cristallini
authors.affiliation: Pathological Anatomy Service, Foligno Hospital, I-06034 Foligno, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Toraldo
authors.affiliation: Private Practitioner, I-06034 Foligno, Italy.
authors.forename: Cardarelli
authors.initials: C
authors.lastname: Lorenzo
authors.affiliation: Department of Maxillofacial Surgery, Foligno Hospital, I-06034 Foligno, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Falchi
authors.affiliation: Maxillofacial Surgery Unit, Faculty of Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, I-00168 Rome.
authors.forename: Gianmarco
authors.initials: G
authors.lastname: Saponaro
keywords: ameloblastic carcinoma; ameloblastoma; malignant ameloblastoma; maxillary tumor; odontogenic tumor