title: Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy.
abstract: We analyzed quantitative maps ofT1andT2relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age-range-matched healthy volunteer boys. The cardiac-optimized sequences detected fatty infiltration and edema in the upper arm skeletal muscles but not the myocardium in these Duchenne muscular dystrophy boys who had normal ejection fraction. Imaging the heart and skeletal muscle using the same magnetic resonance imaging methods during a single scan may be useful in assessing relative disease status and therapeutic response in clinical trials of Duchenne muscular dystrophy.
authors.affiliation: Advanced Cardiovascular Imaging National Heart, Lung and Blood Institute Bethesda Maryland; Present address: Pediatric Cardiology The Johns Hopkins Hospital Baltimore Maryland.
authors.forename: Lasya
authors.initials: L
authors.lastname: Gaur
authors.affiliation: Advanced Cardiovascular Imaging National Heart, Lung and Blood Institute Bethesda Maryland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hanna
authors.affiliation: Advanced Cardiovascular Imaging National Heart, Lung and Blood Institute Bethesda Maryland.
authors.forename: W Patricia
authors.initials: WP
authors.lastname: Bandettini
authors.affiliation: Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Fischbeck
authors.affiliation: Advanced Cardiovascular Imaging National Heart, Lung and Blood Institute Bethesda Maryland.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Arai
authors.affiliation: Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland.
authors.forename: Ami
authors.initials: A
authors.lastname: Mankodi