title: Pregnancy Outcomes After Direct Uterine Myoma Thermal Ablation: Review of the Literature.
abstract: The objective of this review is to describe the reproductive outcomes of women after radiofrequency volumetric thermal ablation (RFVTA) of myomas or magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU). This is a literature review of the current case reports of reproductive outcomes after direct myoma thermal ablation at multiple academic and private centers throughout the world. A literature search was performed using PubMed and Medline. All publications that included data of women who underwent radiofrequency myoma ablation or MRgHIFU of myomas and subsequently conceived were included. There were 122 pregnancies after direct uterine myoma thermal ablation, and 20 pregnancies were reported after RFVTA. Of these cases, there was 1 spontaneous abortion and 7 elective terminations. The remaining 12 pregnancies went on to have live full-term deliveries, 9 (75%) by cesarean section and 3 (25%) by vaginal delivery. There were no reports of uterine abnormalities at delivery and 1 delayed postpartum hemorrhage with expulsion of a degenerated myoma. There are 102 reported pregnancies after MRgHIFU. There were 21 spontaneous abortions and 22 elective terminations, 48 deliveries, and 11 ongoing pregnancies at the time of report. There was 1 preterm delivery at 36 weeks due to placenta previa, and the remaining deliveries were full term. The complications reported included vaginal spotting (12.5%), delayed placental separation (4%), and placenta previa (4%). There were no cases of uterine rupture. In summary, RFVTA and MRgHIFU are new minimally invasive alternatives for the treatment of myomas. Further investigation into the reproductive outcomes after these myoma therapies is crucial to determine whether these are appropriate treatment options for women with symptomatic myomas who desire future fertility.
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York. Electronic address: jkeltz@montefiore.org.
authors.forename: Julia
authors.initials: J
authors.lastname: Keltz
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Mark
authors.initials: M
authors.lastname: Levie
authors.affiliation: Stamford Hospital, Stamford, Connecticut.
authors.forename: Scott
authors.initials: S
authors.lastname: Chudnoff
mesh_terms: D000022:Abortion, Spontaneous; D017115:Catheter Ablation; D002585:Cesarean Section / Q000706:statistics & numerical data; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014594:Uterine Neoplasms / Q000601:surgery*
keywords: Myoma; Myoma thermal ablation; Pregnancy