title: Association between glycemic variability and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome during 30-day follow-up.
abstract: BACKGROUND
  We explored the association between glycemic variability and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome (ACS) during 30-day follow-up.
  
  
  METHODS
  From May 2013 to April 2015, a total of 864 patients with ACS were divided to high glycemic variability group (H group) (n=285) and low glycemic variability group (L group) (n=579). The primary end point was a 30-day incidence of MACCE. Secondary end points were the incidence of atrial fibrillation (AF) during hospitalization and length of hospital stay.
  
  
  RESULTS
  The primary end point occurred in 15.2% of patients in H group and in 9.7% in L group (p=0.03). The incidence of AF during hospitalization was 14.5% in H group and 8.9% in L group (p=0.02). Compared with the L group, the H group extended the length of hospital stay. Multivariable analysis suggested that high glycemic variability conferred a 57% risk increment of 30-day MACCE (odds ratio 1.97, 95% confidence interval 1.32-6.86; p=0.02).
  
  
  CONCLUSIONS
  The trial shows that higher blood glucose variability was correlated with higher incidence of MACCE, AF and longer length of stay.
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Jinggang
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Boyu
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Hengjian
authors.initials: H
authors.lastname: Hao
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.. Electronic address: yinclmail@gmail.com.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Yin
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.. Electronic address: xudheart@aliyun.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications*; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000209:etiology; D001786:Blood Glucose / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000097:blood / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008875:Middle Aged
chemical_list: D001786:Blood Glucose
keywords: Acute coronary syndrome; Diabetes mellitus; Glucose fluctuation; MACCE