title: Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis.
abstract: BACKGROUND
  Pneumonia is a common and serious infectious disease that can cause high mortality. The role of lung ultrasound (LUS) in the diagnosis of pneumonia is becoming more and more important.
  
  
  METHODS
  In the present study, we collected existing evidence regarding the use of LUS to diagnose pneumonia in adults and conducted a systematic review to summarize the technique's diagnostic accuracy. We specifically searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Embase databases and retrieved outcome data to evaluate the efficacy of LUS for the diagnosis of pneumonia compared with chest radiography or chest computed tomography. The pooled sensitivity (SEN) and specificity (SPE) were determined using the Mantel-Haenszel method, and the pooled diagnostic odds ratio (DOR) was determined using the DerSimonian-Laird method. We also assessed heterogeneity of sensitivity, specificity, and diagnostic odds ratio using the Q and I statistics.
  
  
  RESULTS
  Twelve studies containing 1515 subjects were included in our meta-analysis. The SEN and SPE were 0.88 (95% CI: 0.86-0.90) and 0.86 (95% CI: 0.83-0.88), respectively. The pooled negative likelihood ratio (LR) was 0.13 (95% CI: 0.08-0.23), the positive LR was 5.37 (95% CI: 2.76-10.43), and the DOR was 65.46 (95% CI: 29.24-146.56). The summary receiver operating characteristic curve indicated a relationship between sensitivity and specificity. The area under the curve for LUS was 0.95.
  
  
  CONCLUSIONS
  LUS can help to diagnose adult pneumonia with high accuracy.
authors.affiliation: Department of Intensive Care Unit, Hebei General Hospital, Hebei, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Long
authors.forename: Hao-Tian
authors.initials: HT
authors.lastname: Zhao
authors.forename: Zhi-Yang
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Wang
authors.forename: He-Ling
authors.initials: HL
authors.lastname: Zhao
mesh_terms: D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D011014:Pneumonia / Q000000981:diagnostic imaging*; D014463:Ultrasonography