title: NK-DC Crosstalk in Immunity to Microbial Infection.
abstract: The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contacts and soluble factors. This interaction either in the periphery or in the secondary lymphoid organs acts as a key player linking innate and adaptive immune responses to microbial stimuli. This review focuses on the mechanisms of NK-DC interaction and their relevance in antimicrobial responses. We specifically aim to emphasize the ability of various microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response.
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5.
authors.forename: Rony
authors.initials: R
authors.lastname: Thomas
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5.
authors.forename: Xi
authors.identifier: 0000-0002-8831-7488
authors.initials: X
authors.lastname: Yang
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D010272:Parasitic Diseases / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*