title: Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission.
abstract: Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4-6.1) in sepsis and 0.6 ng/ml (0.4-0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure.
authors.affiliation: Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Holst
authors.affiliation: Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. szakmanyt1@cardiff.ac.uk.|ACT Directorate, Cwm Taf University Health Board, Llantrisant, CF72 8XR, UK. szakmanyt1@cardiff.ac.uk.|Anaesthetic Directorate, Aneurin Bevan University Health Board, Newport, NP20 5UB, UK. szakmanyt1@cardiff.ac.uk.
authors.forename: Tamas
authors.identifier: http://orcid.org/0000-0003-3632-8844
authors.initials: T
authors.lastname: Szakmany
authors.affiliation: Division of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK.
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Raby
authors.affiliation: Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.|Anaesthetic Directorate, Aneurin Bevan University Health Board, Newport, NP20 5UB, UK.
authors.forename: Vincent
authors.initials: V
authors.lastname: Hamlyn
authors.affiliation: Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
authors.forename: Kimberley
authors.initials: K
authors.lastname: Durno
authors.affiliation: Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
authors.forename: Judith E
authors.initials: JE
authors.lastname: Hall
authors.affiliation: Division of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK. Labeta@cardiff.ac.uk.
authors.forename: Mario O
authors.initials: MO
authors.lastname: Labéta