title: Fc-fusion Proteins in Therapy: An Updated View.
abstract: Fc-fusion proteins are composed of Fc region of IgG antibody (Hinge-CH2-CH3) and a desired linked protein. Fc region of Fc-fusion proteins can bind to neonatal Fc receptor (FcRn) thereby rescuing it from degradation. The first therapeutic Fc-fusion protein was introduced for the treatment of AIDS. The molecular designing is the first stage in production of Fc-fusion proteins. The amino acid residues in the Fc region and linked protein are very important in the bioactivity and affinity of the fusion proteins. Although, therapeutic monoclonal antibodies are the top selling biologics but the application of therapeutic Fc-fusion proteins in clinic is in progress and among these medications Etanercept is the most effective in therapy. At present, eleven Fc-fusion proteins have been approved by FDA. There are novel Fc-fusion proteins which are in pre-clinical and clinical development. In this article, we review the molecular and biological characteristics of Fc-fusion proteins and then further discuss the features of novel therapeutic Fc-fusion proteins.
authors.affiliation: Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Jafari
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz. Iran.
authors.forename: Naime M
authors.initials: NM
authors.lastname: Zolbanin
authors.affiliation: Inflammation and Inflammatory Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.
authors.forename: Houshang
authors.initials: H
authors.lastname: Rafatpanah
authors.affiliation: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz. Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Majidi
authors.affiliation: Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, P.O. Box: 5165683146, Tabriz. Iran.
authors.forename: Tohid
authors.initials: T
authors.lastname: Kazemi
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy*; D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry* / Q000276:immunology / Q000627:therapeutic use*; D011961:Receptors, Fc / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D007141:Immunoglobulin Fc Fragments; D011961:Receptors, Fc; C100688:Fc receptor, neonatal
keywords: Fc region; Fc-fusion proteins; FcRn; antibody; immunotherapy