title: Key Structural Elements for Cellular Uptake of Acinetobactin, a Major Siderophore of Acinetobacter baumannii.
abstract: Acinetobactin is a major siderophore utilized by the human pathogen Acinetobacter baumannii. The rapid acquisition of drug resistance by A. baumannii has garnered concern globally. Herein, acinetobactin and systematically generated analogues were prepared and characterized; the binding and cellular delivery of Fe(III) by the analogues were evaluated. This investigation not only led to the clarification of the physiologically relevant acinetobactin structure but also revealed several key structural elements for its functionality as a siderophore.
authors.affiliation: Department of Chemistry, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors.forename: Woon Young
authors.initials: WY
authors.lastname: Song
authors.affiliation: Department of Chemistry, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors.forename: Dawa
authors.initials: D
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors.forename: Jimin
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors.forename: Min Wook
authors.initials: MW
authors.lastname: Lee
authors.affiliation: Department of Nanobiomedical Science, Dankook University , Cheonan 31116, Republic of Korea.
authors.forename: Man Hwan
authors.initials: MH
authors.lastname: Oh
authors.affiliation: Department of Chemistry, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors.forename: Hak Joong
authors.identifier: 0000-0002-3213-2230
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D040981:Acinetobacter baumannii; D005290:Ferric Compounds; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D017262:Siderophores
chemical_list: D005290:Ferric Compounds; D007093:Imidazoles; D010080:Oxazoles; D017262:Siderophores; C091186:acinetobactin