title: Importance of secreted bacterial RNA in bacterial-host interactions in the gut.
abstract: Bacteria are ubiquitous in nature and found to be associated with human. Humans are benefited significantly from these associated bacteria. Our understanding is quite limited about these beneficial associations and how bacteria communicate with the host. It is assumed that secreted bacterial products contribute in bacterial-host signaling. A few studies have shown that bacteria secrete RNA into their extracellular medium, and these secreted RNA are capable of altering the host immune response. Multiple studies in eukaryotes have confirmed that secreted RNA can influence the functioning of other cells and their role in the development of several diseases, although not much is known about the composition of secreted bacterial RNA, how they are trafficked and how they impact on the functioning of host cells. By uncovering the beneficial role of secreted bacterial RNA, it would be possible to improve the human health.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address: anubrata@mit.edu.
authors.forename: Anubrata
authors.initials: A
authors.lastname: Ghosal
mesh_terms: D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D012329:RNA, Bacterial / Q000378:metabolism*
chemical_list: D007155:Immunologic Factors; D012329:RNA, Bacterial
keywords: Bacterial-host interaction and gut; Secreted bacterial RNA