title: Zeolite-Based Organic Synthesis (ZeoBOS) of Acortatarin A: First Total Synthesis Based on Native and Metal-Doped Zeolite-Catalyzed Steps.
abstract: Similarly to polymer-supported assisted synthesis (PSAS), organic synthesis could be envisaged being performed by using zeolites, native or metal-doped, as heterogeneous catalysts. To illustrate this unprecedented Zeolite-Based Organic Synthesis (ZeoBOS), the total synthesis of acortatarin A was achieved through a novel strategy and using five out of eleven synthetic steps catalyzed by H- or metal-doped zeolites as catalysts. Notably, the formation of an yne-pyrrole intermediate with a copper-doped zeolite and the spiroketalization of an alkyne diol with a silver-doped zeolite have been developed as key steps of the synthesis.
authors.affiliation: Laboratoire de Synthèse, Réactivité Organiques et Catalyse, UMR 7177 associé au CNRS, Institut de Chimie, Université de Strasbourg, 4 rue Blaise Pascal, 67070, Strasbourg, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Wimmer
authors.affiliation: Laboratoire de Synthèse, Réactivité Organiques et Catalyse, UMR 7177 associé au CNRS, Institut de Chimie, Université de Strasbourg, 4 rue Blaise Pascal, 67070, Strasbourg, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Borghèse
authors.affiliation: Laboratoire de Synthèse, Réactivité Organiques et Catalyse, UMR 7177 associé au CNRS, Institut de Chimie, Université de Strasbourg, 4 rue Blaise Pascal, 67070, Strasbourg, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Blanc
authors.affiliation: Laboratoire de Synthèse, Réactivité Organiques et Catalyse, UMR 7177 associé au CNRS, Institut de Chimie, Université de Strasbourg, 4 rue Blaise Pascal, 67070, Strasbourg, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Bénéteau
authors.affiliation: Laboratoire de Synthèse, Réactivité Organiques et Catalyse, UMR 7177 associé au CNRS, Institut de Chimie, Université de Strasbourg, 4 rue Blaise Pascal, 67070, Strasbourg, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Pale
keywords: copper; doped-zeolite; silver; spiroketalization; ynamide formation