title: Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy.
abstract: Herpes simplex encephalitis (HSE) can be complicated by adverse events in the acute phase. We herein present the case of a 71-year-old woman with HSE complicated by cerebral hemorrhage. She presented with acute deterioration of consciousness and fever and was diagnosed with HSE based on the detection of herpes simplex virus-1 in the cerebrospinal fluid by a polymerase chain reaction. The cerebral hemorrhage developed during acyclovir therapy; however, its diagnosis was delayed for 2 days. After the conservative treatment of the cerebral hemorrhage, the patient made a near-complete recovery. Cerebral hemorrhage should be considered as an acute-phase complication of HSE.
authors.affiliation: Department of Internal Medicine, Nagano Chuo Hospital, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Harada
authors.forename: Yuuta
authors.initials: Y
authors.lastname: Hara
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D020803:Encephalitis, Herpes Simplex / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000209:etiology; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D006801:Humans; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir