title: DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs.
abstract: "… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high-throughput screening centers …" Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.
authors.affiliation: The Scripps Research Institute, 10550 North Torrey Pines Road, MB-10, La Jolla, CA 92037, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lerner
authors.affiliation: The Scripps Research Institute, 10550 North Torrey Pines Road, MB-10, La Jolla, CA 92037, USA.
authors.forename: Sydney
authors.initials: S
authors.lastname: Brenner
mesh_terms: D004247:DNA / Q000737:chemistry / Q000378:metabolism; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000378:metabolism
chemical_list: D054852:Small Molecule Libraries; D004247:DNA