title: Functional effector memory T cells contribute to protection from superinfection with heterologous simian immunodeficiency virus or simian-human immunodeficiency virus isolates in Chinese rhesus macaques.
abstract: Many studies have revealed a protective effect of infection of an individual with an immunodeficiency virus against subsequent infection with a heterologous strain. However, the extent of protection against superinfection conferred by the first infection and the biological consequences of superinfection are not well understood. Here, we report that a rhesus monkey model of mucosal superinfection was established to investigate the protective immune response. Protection against superinfection was shown to correlate with the extent of the polyfunctionality of CD4+effector memory T cells, whereas neutralizing antibody responses did not protect against superinfection in this model. Notably, immunodeficiency-virus-associated effector memory T-cell responses might significantly contribute to the suppression of virus superinfection. This provides a potential theoretical basis for the development of an HIV/AIDS vaccine.
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Sun
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Huiwen
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Molecular Microbiology and Technology, College of Life Sciences, Ministry of Education, Nankai University, Tianjin, 300071, China.
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Bingxiang
authors.initials: B
authors.lastname: Li
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Haiting
authors.initials: H
authors.lastname: Long
authors.affiliation: Key Laboratory of Molecular Microbiology and Technology, College of Life Sciences, Ministry of Education, Nankai University, Tianjin, 300071, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Guo
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Ruotong
authors.initials: R
authors.lastname: Ning
authors.affiliation: Key Laboratory of Molecular Microbiology and Technology, College of Life Sciences, Ministry of Education, Nankai University, Tianjin, 300071, China. yueli@nankai.edu.cn.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming, China. longdingl@gmail.com.
authors.forename: Longding
authors.initials: L
authors.lastname: Liu
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007156:Immunologic Memory / Q000276:immunology*; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000473:pathology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000302:isolation & purification; D015163:Superinfection / Q000276:immunology* / Q000517:prevention & control / Q000821:virology*; D019562:Viral Load
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral