title: Chronic myelomonocytic leukemia with double-mutations in DNMT3A and FLT3-ITD treated with decitabine and sorafenib.
abstract: Chronic myelomonocytic leukemia (CMML) is a heterogeneous neoplastic hematologic disorder with worse overall survival. Half of CMML have mutations, but case with concomitant mutations of DNA methyltransferase 3A (DNMT3A) and Internal tandem duplications of the juxtamembrane domain of FLT3 (FLT3-ITD) in CMML was not reported before. We reported a 51-year-old man who had CMML with concomitant mutations in DNMT3A and FLT3-ITD.The patient received decitabine and sorafenib combined treatment. In this report, we reviewed DNMT3A mutation and FLT3 mutation, and we reviewed treatment of decitabine and sorafenib. This report is significant. First: This is the first report on CMML with double-mutations of DNMT3A and FLT3-ITD. Second: It shows the importance of targeted drug in combined treatment of CMML.
authors.affiliation: a Department of Hematology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Da Dao, Wuhan , P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Gu
authors.affiliation: a Department of Hematology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Da Dao, Wuhan , P. R. China.
authors.forename: Zhiqiong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Department of Hematology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Da Dao, Wuhan , P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Xiao
authors.affiliation: a Department of Hematology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Da Dao, Wuhan , P. R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Mao
authors.affiliation: a Department of Hematology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Da Dao, Wuhan , P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.affiliation: a Department of Hematology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Da Dao, Wuhan , P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Department of Hematology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Da Dao, Wuhan , P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D001374:Azacitidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics* / Q000378:metabolism; D000090205:DNA Methyltransferase 3A; D000077209:Decitabine; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D000077157:Sorafenib; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics* / Q000378:metabolism
chemical_list: C000717967:DNMT3A protein, human; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077209:Decitabine; D000077157:Sorafenib; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D001374:Azacitidine
keywords: CMML; DNMT3A; FLT3-ITD; double-mutations; sorafenib