title: Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients.
abstract: The presented article studies the role of selected inflammatory and anti-inflammatory serum markers of psoriatic patients in the pathogenesis of metabolic syndrome (MS) and psoriasis. The study is based on the comparison between the group of psoriatic patients (74) and the control group (65). We found significantly higher BMI (p< 0.05) and diastolic blood pressure (p< 0.05) in the psoriatic patients. The values of waist circumference and BMI were significantly higher (p< 0.05) in the male patients compared to the men in the control group. The analysis revealed significantly higher CRP (p< 0.001), Lp-PLA2 (p< 0.001), leptin (p< 0.01), and resistin (p< 0.01) levels in the psoriatic patients. Significantly higher levels of CRP (p< 0.01), Lp-PLA2 (p< 0.001), leptin (p< 0.01), and resistin (p< 0.05) were found in the patients with MS compared to the controls with MS. The level of adiponectin was significantly lower (p< 0.01) in the patients with MS. Finally, we found significantly higher level of Lp-PLA2 (p< 0.001) in the group of patients without MS compared to the controls without MS. In conclusion, observed inflammatory and anti-inflammatory markers (CRP, adiponectin, leptin, resistin, and Lp-PLA2) are involved in both pathogenesis of MS and pathogenesis of psoriasis. The level of Lp-PLA2 indicates the presence of subclinical atherosclerosis (cardiovascular risk) in psoriatic patients.
authors.affiliation: Department of Dermatology and Venereology, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic.
authors.forename: Simona
authors.initials: S
authors.lastname: Vachatova
authors.affiliation: Institute of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
authors.affiliation: Institute of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
authors.forename: Jan
authors.identifier: 0000-0003-2778-6800
authors.initials: J
authors.lastname: Krejsek
authors.affiliation: Department of Dermatology and Venereology, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic.
authors.forename: Miloslav
authors.initials: M
authors.lastname: Salavec
authors.affiliation: Department of Dermatology and Venereology, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Ettler
authors.affiliation: Department of Transfusion Medicine, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic.
authors.forename: Vit
authors.initials: V
authors.lastname: Rehacek
authors.affiliation: Department of Medical Biophysics, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Cermakova
authors.affiliation: Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
authors.forename: Andrea
authors.initials: A
authors.lastname: Malkova
authors.affiliation: Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
authors.forename: Zdenek
authors.identifier: 0000-0001-9978-5757
authors.initials: Z
authors.lastname: Fiala
authors.affiliation: Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic.
authors.forename: Lenka
authors.identifier: 0000-0002-8580-1485
authors.initials: L
authors.lastname: Borska
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000276:immunology / Q000473:pathology*; D052243:Resistin / Q000097:blood*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D052243:Resistin; D002097:C-Reactive Protein; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase