title: Peritoneal Dialysis in Class 2-3 Obesity-A Single-Center Experience.
abstract: Extreme obesity may hamper successful peritoneal dialysis (PD) delivery. Among our PD patients, we have identified 15 markedly obese (class 2-3 obesity: body mass index [BMI] ≥35kg/m2) and 20 lean (BMI: 20-25kg/m2) dialysis patients and reviewed multiple clinical, laboratory and dialysis-related parameters. Extreme outliers of obesity (BMI > 40; 6 subjects) received detailed review. Although weight (P < 0.0001) and BMI (P < 0.0001) differed significantly, weekly Kt/V (obese versus lean: 2.05 ± 0.51 versus 2 ± 0.36), creatinine clearance (86.8 ± 44.8 versus 70 ± 30.4L/1.73m2) or residual renal functions were not statistically different. Total daily PD exchange volumes were similar (11.2 ± 2.5L versus 10.4 ± 2.5L, P = 0.378). Serum albumin, calcium, phosphorus, hemoglobin and parathyroid hormone levels did not differ, either. Analogous results have been obtained for extremely obese subjects (BMI 44.3 ± 4.2kg/m2; range: 40.2-51.6). Our study shows only limited effect of class ≥2 obesity for successful PD in this predominantly African American cohort.
authors.affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
authors.forename: Yougandhar V
authors.initials: YV
authors.lastname: Akula
authors.affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi. Electronic address: tiborfulop.nephro@gmail.com.
authors.forename: Tibor
authors.initials: T
authors.lastname: Fülöp
authors.affiliation: Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi.
authors.forename: Mehul P
authors.initials: MP
authors.lastname: Dixit
mesh_terms: D000328:Adult; D001741:Black or African American; D015992:Body Mass Index; D001835:Body Weight; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D010530:Peritoneal Dialysis
chemical_list: D003404:Creatinine
keywords: African American; Anthropometrics; Body mass index; Dialysis adequacy; End-stage renal disease