title: Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region.
abstract: Depolymerizing actin in the amygdala through nonmuscle myosin II inhibition (NMIIi) produces a selective, lasting, and retrieval-independent disruption of the storage of methamphetamine-associated memories. Here we report a similar disruption of memories associated with amphetamine, but not cocaine or morphine, by NMIIi. Reconsolidation appeared to be disrupted with cocaine. Unlike in the amygdala, methamphetamine-associated memory storage was not disrupted by NMIIi in the hippocampus, nucleus accumbens, or orbitofrontal cortex. NMIIi in the hippocampus did appear to disrupt reconsolidation. Identification of the unique mechanisms responsible for NMII-mediated, amygdala-dependent disruption of memory storage associated with the amphetamine class may enable induction of retrieval-independent vulnerability to other pathological memories.
authors.affiliation: Department of Metabolism & Aging, The Scripps Research Institute, Jupiter, Florida 33458, USA.|Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
authors.forename: Sherri B
authors.initials: SB
authors.lastname: Briggs
authors.affiliation: Department of Metabolism & Aging, The Scripps Research Institute, Jupiter, Florida 33458, USA.|Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Blouin
authors.affiliation: Department of Metabolism & Aging, The Scripps Research Institute, Jupiter, Florida 33458, USA.|Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
authors.forename: Erica J
authors.initials: EJ
authors.lastname: Young
authors.affiliation: Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
authors.forename: Gavin
authors.initials: G
authors.lastname: Rumbaugh
authors.affiliation: Department of Metabolism & Aging, The Scripps Research Institute, Jupiter, Florida 33458, USA.|Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA.
authors.forename: Courtney A
authors.initials: CA
authors.lastname: Miller
mesh_terms: D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D049229:Dendritic Spines / Q000187:drug effects / Q000648:ultrastructure; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006576:Heterocyclic Compounds, 4 or More Rings / Q000633:toxicity*; D008569:Memory Disorders / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D011939:Mental Recall / Q000187:drug effects*; D008694:Methamphetamine / Q000008:administration & dosage; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008845:Microinjections; D009022:Morphine Derivatives / Q000008:administration & dosage / Q000494:pharmacology; D024462:Myosin Type II / Q000378:metabolism*
chemical_list: D000779:Anesthetics, Local; D000697:Central Nervous System Stimulants; D006576:Heterocyclic Compounds, 4 or More Rings; D009022:Morphine Derivatives; D049452:Green Fluorescent Proteins; C472645:blebbistatin; D008694:Methamphetamine; D024462:Myosin Type II; D003042:Cocaine