title: Comparison of Drug-Eluting Balloon and Standard Balloon Angioplasty for Infrapopliteal Arterial Diseases in Diabetic Patients.
abstract: OBJECTIVE
  To consider the clinical outcomes and restenosis rates of drug-eluting balloons (DEBs) and percutaneous transluminal angioplasty (PTA) in diabetic patients with infrapopliteal (IP) arterial disease.
  
  
  METHODS
  This retrospective, single-center study included 51 patients (37 males; mean age: 63.43 ± 9.81 years) with diabetes mellitus having IP arterial disease, from October 2012 to September 2014. Twenty-two patients were treated with PTA, and 29 patients were treated with DEBs. After intervention, the patients were evaluated in the first week and every 3 months, clinically and radiologically. Univariate and multivariate analyses were used to evaluate the clinical outcomes of diabetic patients with IP arterial disease who were treated with either DEBs or PTA.
  
  
  RESULTS
  There were no statistically significant differences between the groups in terms of age and gender, risk factors, characteristics of lesions, or the diameters or length of the balloons ( P > .05). Primary patency was higher in the DEB group than in the PTA group (97.8% vs 81.1%, P = .020) in the first 3 months. However, there was no statistically significant difference at 1-year follow-up (68.2% vs 48.5%, P = .131). At the 12-month follow-up, there was no difference in clinical improvement between the groups ( P = .193).
  
  
  CONCLUSIONS
  The findings of this study reveal that DEB is a safe alternative treatment method for IP arterial disease in diabetic patients.
authors.affiliation: 1 Department of Radiology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Ibrahim Ilker
authors.initials: II
authors.lastname: Oz
authors.affiliation: 2 Department of Radiology, Bagcilar Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Serifoglu
authors.affiliation: 3 Department of Internal Medicine, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Bilici
authors.affiliation: 4 Department of Radiology, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Namik Kemal
authors.initials: NK
authors.lastname: Altinbas
authors.affiliation: 5 Department of Anesthesiology and Reanimation, Zonguldak State Hospital, Zonguldak, Turkey.
authors.forename: Evrim Bozay
authors.initials: EB
authors.lastname: Oz
authors.affiliation: 6 Department of Radiology, School of Medicine, Saint Louis University, St Louis, MO, USA.
authors.forename: Ece Isin
authors.initials: EI
authors.lastname: Akduman
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000295:instrumentation*; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D020099:Coated Materials, Biocompatible; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017239:Paclitaxel / Q000008:administration & dosage*; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey; D062666:Vascular Access Devices; D014654:Vascular Patency
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible; D017239:Paclitaxel
keywords: diabetes mellitus; drug-eluting balloon; infrapopliteal arterial disease; percutaneous transluminal angioplasty