title: Hidradenitis suppurativa and perianal Crohn disease: differential diagnosis.
abstract: The first description of perianal fistulas and complications in Crohn disease was made 75 years ago by Penner and Crohn. Published studies have subsequently confirmed that perianal fistulas are the most common manifestations of fistulising Crohn disease. Hidradenitis suppurativa was described in 1854 by a French surgeon, Aristide Verneuil. It is a chronic, inflammatory, recurrent and debilitating disease of the pilosebaceous follicle, that usually manifests after puberty with deep, painful and inflamed lesions in the areas of the body with apocrine glands, usually the axillary, inguinal and anogenital regions. The differential diagnosis between hidradenitis suppurativa and Crohn disease can be challenging, especially when the disease is primarily perianal. When they occur simultaneously, hidradenitis suppurativa and Crohn disease show severe phenotypes and patients can respond to anti-tumour necrosis factor therapy, although adalimumab is currently the only treatment with demonstrated efficacy in hidradenitis suppurativa and Crohn disease. In addition, there is sometimes a need for different complementary surgical procedures.
authors.affiliation: Servei de Dermatologia, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España. Electronic address: julibassas@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Bassas-Vila
authors.affiliation: Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología y Hepatología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
authors.forename: Y
authors.initials: Y
authors.lastname: González Lama
mesh_terms: D000068879:Adalimumab / Q000627:therapeutic use; D001004:Anus Diseases / Q000209:etiology / Q000601:surgery; D001685:Biological Factors / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000209:etiology; D003113:Colonoscopy; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D017577:Cutaneous Fistula / Q000209:etiology / Q000601:surgery; D003937:Diagnosis, Differential; D017497:Hidradenitis Suppurativa / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007412:Intestinal Fistula / Q000209:etiology / Q000601:surgery; D009928:Organ Specificity; D010641:Phenotype; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D001685:Biological Factors; D014409:Tumor Necrosis Factor-alpha; D000068879:Adalimumab
keywords: Crohn disease; Diagnóstico diferencial; Differential diagnosis; Enfermedad de Crohn; Hidradenitis suppurativa; Hidradenitis supurativa