title: In VitroActivity of Ceftolozane-Tazobactam against Multidrug-Resistant Nonfermenting Gram-Negative Bacilli Isolated from Patients with Cystic Fibrosis.
abstract: Ceftolozane-tazobactam was tested against 58 multidrug-resistant nonfermenting Gram-negative bacilli (35Pseudomonas aeruginosa, 11Achromobacter xylosoxydans, and 12Stenotrophomonas maltophiliaisolates) isolated from cystic fibrosis patients and was compared to ceftolozane alone, ceftazidime, meropenem, and piperacillin-tazobactam. Ceftolozane-tazobactam was the most active agent againstP. aeruginosabut was inactive againstA. xylosoxydansandS. maltophiliaIn time-kill experiments, ceftolozane-tazobactam had complete bactericidal activity against 2/6 clinical isolates (33%).
authors.affiliation: Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Grohs
authors.affiliation: Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: Gary
authors.initials: G
authors.lastname: Taieb
authors.affiliation: Service de Bactériologie, Assistance Publique-Hôpitaux de Paris, GH Cochin-Hôtel Dieu-Broca, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Morand
authors.affiliation: Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: Iheb
authors.initials: I
authors.lastname: Kaibi
authors.affiliation: Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Podglajen
authors.affiliation: Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, France.|INSERM, UMR S 1138, Centre de Recherche des Cordeliers, Equipe 12, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Lavollay
authors.affiliation: Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, France.|INSERM, UMR S 1138, Centre de Recherche des Cordeliers, Equipe 12, Paris, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Mainardi
authors.affiliation: Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France fabrice.compain@aphp.fr.|Université Paris Descartes, Sorbonne Paris Cité, France.|INSERM, UMR S 1138, Centre de Recherche des Cordeliers, Equipe 12, Paris, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Compain
mesh_terms: D042441:Achromobacter denitrificans / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D000077725:Piperacillin, Tazobactam Drug Combination; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D020615:Stenotrophomonas maltophilia / Q000187:drug effects; D000078142:Tazobactam; D013845:Thienamycins / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013845:Thienamycins; D000077725:Piperacillin, Tazobactam Drug Combination; C519491:ceftolozane; D010397:Penicillanic Acid; D002442:Ceftazidime; D000077731:Meropenem; D000078142:Tazobactam; D010878:Piperacillin
keywords: Achromobacter; Pseudomonas; Stenotrophomonas; bactericidal activity; ceftolozane; cystic fibrosis