title: Pulmonary intravascular large B-cell lymphoma successfully treated with rituximab, cyclophosphamide, vincristine, doxorubicin and prednisolone immunochemotherapy: Report of a patient surviving for over 1 year.
abstract: A 73-year-old man with a history of lethargy, fever and dyspnea was admitted to Tottori University Hospital. A computed tomography (CT) scan revealed splenomegaly and diffusely spreading ground-glass opacities (GGOs) in both lungs. A video-assisted thoracoscopic surgery (VATS)-guided lung biopsy revealed intravascular proliferation of large atypical lymphoid cells in the arteries, veins and alveolar walls. The patient was diagnosed with intravascular large B-cell lymphoma (IVLBCL); he received 6 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) immunochemotherapy and has remained in complete remission for >1 year. Although IVLBCL is a rare disease, it should be considered in the differential diagnosis of pulmonary diffuse lesions that present with GGOs on CT scans.
authors.affiliation: Department of Hematology, Tottori University Hospital, Yonago, Tottori 683-8504, Japan; Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Nishii-Ito
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Izumi
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Touge
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takeda
authors.affiliation: Department of Hematology, Tottori University Hospital, Yonago, Tottori 683-8504, Japan; Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Hosoda
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamasaki
authors.affiliation: Division of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwamoto
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
authors.affiliation: Department of Hematology, Tottori University Hospital, Yonago, Tottori 683-8504, Japan; Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Motokura
keywords: ground-glass opacities; intravascular large B-cell lymphoma; rituximab