title: Design, synthesis and biological evaluation of six dinuclear platinum(II) complexes.
abstract: Six dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R,1'R,2R,2'R)-N1,N1'-(1,4-phenylenebis(methylene))dicyclohexane-1,2-diamine, have been designed, synthesized and characterized. In vitro cytotoxicity evaluation of these metal complexes against human A549, HCT-116, MCF-7 and HepG-2 cell lines have been carried out. All compounds showed antitumor activity to HepG-2, HCT-116 and A549. Particularly, compounds A1 and A2 exhibited significant better activity than other four compounds and A2 even showed comparable cytotoxicity to cisplatin against HepG-2 cell line.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Congtao
authors.initials: C
authors.lastname: Yu
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: gczasd@163.com.
authors.forename: Chuanzhu
authors.initials: C
authors.lastname: Gao
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Linkui
authors.initials: L
authors.lastname: Bai
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Zhuxin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China; Engineering Laboratory for Advanced Battery and Material of Yunnan Province, Kunming 650500, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; Department of Cardiovascular Medicine, Wenshan People's Hospital, Wenshan 663000, China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Li
authors.affiliation: Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China; Engineering Laboratory for Advanced Battery and Material of Yunnan Province, Kunming 650500, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Dong
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; Department of Cardiovascular Medicine, Wenshan People's Hospital, Wenshan 663000, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Sun
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Yunxu
authors.initials: Y
authors.lastname: Qian
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017671:Platinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds
keywords: Anticancer; Cytotoxicity; DNA insertion group; Dinuclear platinum(II) complexes