title: Effects of prenatal iron status on child neurodevelopment and behavior: A systematic review.
abstract: Iron deficiency and iron-deficiency anemia are the main worldwide nutritional disorders. A good level of prenatal iron is essential for the correct child neurodevelopment but this association has been poorly investigated. To gather the scientific evidence on the relation between prenatal iron status and child neurodevelopment. To emphasize the importance of personalize the dose and type of supplementation. Wide search strategy was performed in electronic databases for English language articles with no limitations as regards the language or date of publication. Additional studies were selected by hand search. The inclusion criteria were pregnant women without high-risk pregnancy and their children as study population and neurodevelopment as the main outcome. Six RCTs and 13 observational studies were included. The majority concluded that deficit or excess iron during pregnancy injures the mental and psychomotor development of child. Other authors found no association of low iron level with troubles in neurodevelopment, recommended multi-micronutrients instead of iron alone and/or showed inconsistent results. Both iron deficiency as its excess are harmful for the child neurodevelopment. The prenatal iron supplementation should be adjusted for each woman, taking into account the iron stores, some genetic mutation and other health habits.
authors.affiliation: a Unit of Preventive Medicine and Public Health, Faculty of Medicine and Health Science , Universitat Rovira I Virgili , Reus , Spain.
authors.forename: Lucía
authors.identifier: http://orcid.org/0000-0001-7131-4144
authors.initials: L
authors.lastname: Iglesias
authors.affiliation: b Unit of Psychology, Faculty of Medicine and Health Science , Universitat Rovira I Virgili , Reus , Spain.
authors.forename: Josefa
authors.identifier: http://orcid.org/0000-0002-6209-9558
authors.initials: J
authors.lastname: Canals
authors.affiliation: a Unit of Preventive Medicine and Public Health, Faculty of Medicine and Health Science , Universitat Rovira I Virgili , Reus , Spain.
authors.forename: Victoria
authors.identifier: http://orcid.org/0000-0002-1758-0975
authors.initials: V
authors.lastname: Arija
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000209:etiology*; D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D002657:Child Development / Q000187:drug effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D000090463:Iron Deficiencies; D019266:Iron, Dietary / Q000008:administration & dosage*; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena
chemical_list: D019266:Iron, Dietary
keywords: Neurodevelopment; children; iron; mental; psychomotor; supplementation