title: T1 mapping using saturation recovery single-shot acquisition at 3-tesla magnetic resonance imaging in hypertrophic cardiomyopathy: comparison to late gadolinium enhancement.
abstract: OBJECTIVE
  We evaluated the T1 values of segments and slices and the reproducibility in healthy controls, using saturation recovery single-shot acquisition (SASHA) at 3T magnetic resonance imaging. Moreover, we examined the difference in T1 values between hypertrophic cardiomyopathy (HCM) and healthy controls, and compared those with late gadolinium enhancement (LGE).
  
  
  METHODS
  Twenty-one HCM patients and 10 healthy controls underwent T1 mapping before and after contrast administration. T1 values were measured in 12 segments.
  
  
  RESULTS
  Native T1 values were significantly longer in HCM than in healthy controls [1373 ms (1312-1452 ms) vs. 1279 ms (1229-1326 ms); p < 0.0001]. Even in HCM segments without LGE, native T1 values were significantly longer than in healthy control segments [1366 ms (1300-1439 ms) vs. 1279 ms (1229-1326 ms); p < 0.0001]. Using a cutoff value of 1327 ms for septal native T1 values, we differentiated between HCM and healthy controls with 95% sensitivity, 90% specificity, 94% accuracy, and an area under the curve of 0.95.
  
  
  CONCLUSIONS
  Native T1 values using a SASHA at 3T could differentiate HCM from healthy controls. Moreover, native T1 values have the potential to detect abnormal myocardium that cannot be identified adequately by LGE in HCM.
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. ogawa.ryo.th@ehime-u.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Ogawa
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kido
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Teruhito
authors.initials: T
authors.lastname: Kido
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kurata
authors.affiliation: Department of Cardiovascular Internal Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Uetani
authors.affiliation: Department of Cardiovascular Internal Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Ogimoto
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Miyagawa
authors.affiliation: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D005682:Gadolinium
keywords: 3-Tesla magnetic resonance imaging; Hypertrophic cardiomyopathy; Native T1; Saturation recovery single-shot acquisition; T1 mapping