title: Electrophysiological changes in 12-year-old children born MLP: reduced VEP amplitude in MLP children.
abstract: To study the electrophysiological changes in relation to fundus morphology in moderate-to-late preterm (MLP) children with no previous history of retinopathy of prematurity.
  
  
  
  Visual acuity (VA), refraction and fundus variables measured by optical coherence tomography, pattern reversal visual evoked potentials and full-field electroretinography (ff-ERG) were obtained from 22 twelve-year-old MLP children (11 male, 11 female) and 21 full-term controls.
  
  
  
  There were no significant differences between the MLP and control groups in VA, refraction or optic disc parameters. There was a trend for thinner papillary retinal nerve fibre layer in the MLP group. Visual evoked potential amplitudes (P100) were lower in the MLP group than in controls, that is, right eye p=0.0027, left eye p=0.0037. No differences in latencies were found. After Bonferroni adjustment for multiple testing, no ff-ERG differences were noted between MLP and controls. Lower gestational age was correlated with smaller light-adapted 3.0 b-wave amplitudes (p=0.0076, r=0.565).
  
  
  
  Our results indicate that moderate premature birth may affect visual evoked potential amplitudes without clear retinal structural changes in MLP children at 12 years of age.
authors.affiliation: Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.|Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
authors.forename: Lina H
authors.initials: LH
authors.lastname: Raffa
authors.affiliation: Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Josefin
authors.initials: J
authors.lastname: Nilsson
authors.affiliation: Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
authors.forename: Jovanna
authors.initials: J
authors.lastname: Dahlgren
authors.affiliation: Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
authors.forename: Marita Andersson
authors.initials: MA
authors.lastname: Grönlund
mesh_terms: D001724:Birth Weight; D002648:Child; D002657:Child Development; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007234:Infant, Premature; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D009898:Optic Disk / Q000033:anatomy & histology; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
keywords: Electrophysiology; Imaging; Optic Nerve; Visual pathway