title: CYD-TDV dengue vaccine: systematic review and meta-analysis of efficacy, immunogenicity and safety.
abstract: BACKGROUND
  Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia®) was the first vaccine to gain regulatory approval to try and address this problem.
  
  
  OBJECTIVE
  Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine.
  
  
  METHODS
  Meta-analysis and systematic review.
  
  
  RESULTS
  The best and worst immunogenicity results were for DENV4 and DENV1, respectively. Vaccine efficacy of 60% was derived from studies with participants aged 2-16 years old, with DENV4 and DENV2 presenting the best and worst results, respectively. Erythema and swelling were more frequent with CYD-TDV. No differences were detected for systemic adverse events.
  
  
  CONCLUSIONS
  CYD-TDV showed moderate efficacy in children and adolescents. From the immunogenicity results in adults, we can expect satisfactory efficacy from vaccination in this population.
authors.affiliation: Programa de Pós-graduação em Medicamentos e Assistência Farmacêutica, sala 1023, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.|SUS Collaborating Centre for Technology Assessment & Excellence in Health, sala 1042, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
authors.forename: Isabella Piassi
authors.initials: IP
authors.lastname: Godói
authors.affiliation: SUS Collaborating Centre for Technology Assessment & Excellence in Health, sala 1042, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
authors.forename: Livia Lovato Pires
authors.initials: LL
authors.lastname: Lemos
authors.affiliation: Faculdade de Odontologia, Instituto de Ciências Biológicas e da Saúde, Pontifícia Universidade Católica de Minas Gerais, Av. Dom José Gaspar, 500 Coração Eucaristíco, Belo Horizonte, Minas Gerais, CEP 30535-901, Brazil.
authors.forename: Vânia Eloisa
authors.initials: VE
authors.lastname: de Araújo
authors.affiliation: Programa de Pós-graduação em Medicamentos e Assistência Farmacêutica, sala 1023, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
authors.forename: Braúlio Cesar
authors.initials: BC
authors.lastname: Bonoto
authors.affiliation: University of Strathclyde Glasgow, Institute of Pharmacy & Biomedical Sciences, Pharmacoepidemiology, 161 Cathedral Street, Glasgow G4 0RE, UK.|Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, SE-141 86, Stockholm, Sweden.
authors.forename: Brian
authors.initials: B
authors.lastname: Godman
authors.affiliation: Programa de Pós-graduação em Medicamentos e Assistência Farmacêutica, sala 1023, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.|SUS Collaborating Centre for Technology Assessment & Excellence in Health, sala 1042, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
authors.forename: Augusto Afonso
authors.initials: AA
authors.lastname: Guerra Júnior
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000276:immunology / Q000517:prevention & control*; D053059:Dengue Vaccines; D005260:Female; D006801:Humans; D000071497:Immunogenicity, Vaccine; D008297:Male; D061214:Patient Safety; D016896:Treatment Outcome
chemical_list: C000603176:CYD-TDV vaccine; D053059:Dengue Vaccines
keywords: CYD-TDV; dengue; meta-analysis; systematic review; vaccines