title: Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis.
abstract: OBJECTIVE
  To characterize the immunologic profile in aqueous humor (AqH) of HIV-infected individuals with cytomegalovirus retinitis (CMVr) or ocular syphilis and to assess if AqH and plasma represent independent cytokine compartments.
  
  
  METHODS
  Concentrations of 27 cytokines in AqH and plasma of HIV-infected individuals with CMVr (n = 23) or ocular syphilis (n = 16) were measured by multiplex assay. Cytokine profiles of both groups were compared.
  
  
  RESULTS
  Individuals with CMVr had higher plasma concentrations of interleukin (IL)-7, IL-8, IL-10, interferon (IFN)-γ, IFN-α2, G-CSF, IP-10 and IL-1α; as well as higher AqH concentrations of IL-1α, IP-10 and GM-CSF than those with ocular syphilis. AqH and plasma levels correlated only for IP-10 in both ocular infections.
  
  
  CONCLUSIONS
  Individuals with CMVr had higher plasma cytokine levels than those with ocular syphilis. The immunologic profiles in AqH and plasma are independent. Therefore, AqH cytokine concentrations cannot be inferred from plasma cytokine concentrations in the population studied.
authors.affiliation: a Centro de Investigación en Enfermedades Infecciosas , Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas , Ciudad de México , Mexico.
authors.forename: Matilde
authors.initials: M
authors.lastname: Ruiz-Cruz
authors.affiliation: a Centro de Investigación en Enfermedades Infecciosas , Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas , Ciudad de México , Mexico.
authors.forename: Santiago
authors.initials: S
authors.lastname: Ávila-Rios
authors.affiliation: a Centro de Investigación en Enfermedades Infecciosas , Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas , Ciudad de México , Mexico.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Ormsby
authors.affiliation: a Centro de Investigación en Enfermedades Infecciosas , Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas , Ciudad de México , Mexico.
authors.forename: Yuria
authors.initials: Y
authors.lastname: Ablanedo-Terrazas
authors.affiliation: a Centro de Investigación en Enfermedades Infecciosas , Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas , Ciudad de México , Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Alvarado-de la Barrera
authors.affiliation: a Centro de Investigación en Enfermedades Infecciosas , Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas , Ciudad de México , Mexico.
authors.forename: Leticia
authors.initials: L
authors.lastname: Kuri-Cervantes
authors.affiliation: a Centro de Investigación en Enfermedades Infecciosas , Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas , Ciudad de México , Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Reyes-Terán
mesh_terms: D000328:Adult; D001082:Aqueous Humor / Q000378:metabolism* / Q000821:virology; D018791:CD4 Lymphocyte Count; D016207:Cytokines / Q000097:blood*; D017726:Cytomegalovirus Retinitis / Q000097:blood*; D015818:Eye Infections, Bacterial / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000235:genetics; D013587:Syphilis / Q000097:blood*; D019562:Viral Load
chemical_list: D016207:Cytokines; D012367:RNA, Viral
keywords: AIDS; HIV; cytokines; cytomegalovirus retinitis; ocular syphilis