title: The TGF-β Family inCaenorhabditis elegans.
abstract: Transforming growth factor β (TGF-β) and related ligands have potent effects on an enormous diversity of biological functions in all animals examined. Because of the strong conservation of TGF-β family ligand functions and signaling mechanisms, studies from multiple animal systems have yielded complementary and synergistic insights. In the nematodeCaenorhabditis elegans, early studies were instrumental in the elucidation of TGF-β family signaling mechanisms. Current studies inC. eleganscontinue to identify new functions for the TGF-β family in this organism as well as new conserved mechanisms of regulation.
authors.affiliation: Department of Biology, Queens College, and the Graduate Center, New York, New York 11367.
authors.forename: Cathy
authors.initials: C
authors.lastname: Savage-Dunn
authors.affiliation: Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854-8020.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Padgett
mesh_terms: D000375:Aging; D000818:Animals; D049628:Body Size; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology*; D019070:Cell Lineage; D004475:Ectoderm / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D008136:Longevity; D008648:Mesoderm / Q000502:physiology; D010766:Phosphorylation; D010802:Phylogeny; D055503:Protein Multimerization; D015398:Signal Transduction; D051785:Smad Proteins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D008024:Ligands; D051785:Smad Proteins; D016212:Transforming Growth Factor beta