title: The McGill Interactive Pediatric OncoGenetic Guidelines: An approach to identifying pediatric oncology patients most likely to benefit from a genetic evaluation.
abstract: Identifying cancer predisposition syndromes in children with tumors is crucial, yet few clinical guidelines exist to identify children at high risk of having germline mutations. The McGill Interactive Pediatric OncoGenetic Guidelines project aims to create a validated pediatric guideline in the form of a smartphone/tablet application using algorithms to process clinical data and help determine whether to refer a child for genetic assessment. This paper discusses the initial stages of the project, focusing on its overall structure, the methodology underpinning the algorithms, and the upcoming algorithm validation process.
authors.affiliation: Division of Hematology/Oncology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.|Division of Hematology/Oncology, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Catherine
authors.identifier: http://orcid.org/0000-0003-0670-3121
authors.initials: C
authors.lastname: Goudie
authors.affiliation: Division of Hematology/Oncology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.|Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
authors.forename: Hallie
authors.initials: H
authors.lastname: Coltin
authors.affiliation: Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
authors.forename: Leora
authors.initials: L
authors.lastname: Witkowski
authors.affiliation: Division of Hematology/Oncology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Mourad
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Malkin
authors.affiliation: Department of Human Genetics, McGill University, Montreal, Quebec, Canada.|Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada.|Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
mesh_terms: D000465:Algorithms; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D063731:Mobile Applications; D009369:Neoplasms / Q000235:genetics*
keywords: cancer genetics; cancer predisposition syndrome; familial cancer; germline mutation; pediatric