title: Failing Systemic Right Ventricles With Persistent Pulmonary Hypertension: Candidates for Ventricular Assist Devices as Destination Therapy?
abstract: Dysfunction of the systemic right ventricle is common after the atrial switch procedure for transposition of the great arteries. Cardiac transplantation remains the only long-term solution in terminal systemic right ventricular (RV) failure, but concomitant pulmonary hypertension (PHT) may preclude it. The increasing number of such patients, together with the concerns related to combined heart-lung transplantation (HLTx), urge us to consider other therapeutic options.
authors.affiliation: Department of Cardiac Surgery, University Hospital, Bern, Switzerland. Electronic address: ophelie.loup2@insel.ch.
authors.forename: Ophelie
authors.initials: O
authors.lastname: Loup
authors.affiliation: Department of Cardiology, University Hospital, Bern, Switzerland; Department of Grown-Up Congenital Heart Disease, University Hospital, Bern, Switzerland.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Wustmann
authors.affiliation: Department of Cardiology, University Hospital, Bern, Switzerland; Department of Heart Failure and Transplantation, University Hospital, Bern, Switzerland.
authors.forename: Michele Vittorio
authors.initials: MV
authors.lastname: Martinelli
authors.affiliation: Department of Cardiology, University Hospital, Bern, Switzerland; Department of Grown-Up Congenital Heart Disease, University Hospital, Bern, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Schwerzmann
authors.affiliation: Department of Cardiology, University Hospital, Bern, Switzerland; Department of Heart Failure and Transplantation, University Hospital, Bern, Switzerland.
authors.forename: Paul
authors.initials: P
authors.lastname: Mohacsi
authors.affiliation: Department of Cardiac Surgery, University Hospital, Bern, Switzerland.
authors.forename: Thierry Pierre
authors.initials: TP
authors.lastname: Carrel
authors.affiliation: Department of Cardiac Surgery, University Hospital, Bern, Switzerland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kadner
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000601:surgery; D000328:Adult; D000069278:Arterial Switch Operation / Q000009:adverse effects; D000066491:Clinical Decision-Making; D004374:Ductus Arteriosus, Patent / Q000601:surgery; D017548:Echocardiography, Transesophageal / Q000379:methods; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery; D006353:Heart-Assist Devices; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D014188:Transposition of Great Vessels / Q000601:surgery; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery*