title: Effect of Axial Eye Length on Retinal Vessel Parameters in 6 to 12-Year-Old Malay Girls.
abstract: OBJECTIVE
  Retinal vessel analysis is affected by both systemic and ocular factors. Malays are the major ethnicity in South East Asia. Data on the retinal microvasculature in Malays is limited, especially among children. We aim to evaluate the influence of ocular biometry on retinal vessel parameters in young Malay girls.
  
  
  METHODS
  This was a cross-sectional, hospital-based study involving 86 Malay girls aged 6 to 12 years old in Hospital Universiti Sains Malaysia from 2015-2016. Ocular examination, refraction, biometry, retinal photography, and anthropometric measurements were performed. The central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and overall fractal dimension (Df) were measured using validated computer-based methods (Singapore I vessel analyzer, SIVA version 3.0, Singapore). The associations of ocular biometry and CRAE, CRVE and Df were analyzed using multivariable analysis.
  
  
  RESULTS
  The mean CRAE, CRVE and Df in Malay girls were 171.40 (14.40) um, 248.02 (16.95) um and 1.42 (0.05) respectively. Each 1 mm increase in axial length was associated with a reduction of 4.25 um in the CRAE (p = 0.03) and a reduction of 0.02 in the Df (p = 0.02), after adjustment for age, blood pressure and body mass index. No association was observed between axial length and CRVE. Anterior chamber depth and corneal curvature had no association with CRAE, CRVE or Df.
  
  
  CONCLUSIONS
  Axial length affects retinal vessel measurements. Narrower retinal arterioles and reduced retinal fractal dimension were observed in Malay girls with longer axial lengths.
authors.affiliation: Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.|Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: Evelyn Li Min
authors.initials: EL
authors.lastname: Tai
authors.affiliation: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.|Duke-NUS Medical School, Singapore.
authors.forename: Ling-Jun
authors.initials: LJ
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.|Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: Wan Hitam
authors.initials: WH
authors.lastname: Wan-Hazabbah
authors.affiliation: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.|Duke-NUS Medical School, Singapore.|Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.
authors.forename: Tien-Yin
authors.initials: TY
authors.lastname: Wong
authors.affiliation: Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.|Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors.forename: Ismail
authors.initials: I
authors.lastname: Shatriah
mesh_terms: D000886:Anthropometry; D002648:Child; D003430:Cross-Sectional Studies; D005123:Eye / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008296:Malaysia; D012171:Retinal Vessels / Q000033:anatomy & histology*