title: Thromboelastography in Dogs with Chronic Hepatopathies.
abstract: BACKGROUND
  The coagulation status of dogs with liver disease is difficult to predict using conventional coagulation testing.
  
  
  OBJECTIVE
  To evaluate thromboelastography (TEG) results and associations with conventional coagulation results and indicators of disease severity and prognosis in dogs with chronic hepatopathies (CH).
  
  
  METHODS
  Twenty-one client-owned dogs.
  
  
  METHODS
  Dogs with CH were prospectively (10 dogs) and retrospectively (11 dogs) enrolled from 2008 to 2014. Kaolin-activated TEG was performed and compared with reference intervals by t-tests or Mann-Whitney tests. Correlation coefficients for TEG results and conventional coagulation and clinicopathologic results were determined. Significance was set at P < .05.
  
  
  RESULTS
  Dogs with CH had significant increases in R (5.30 min vs 4.33 min), K (3.77 min vs 2.11 min), and LY30 (4.77% vs 0.68%) and decreased angles (55.3° vs 62.4°). G value defined 9 of 21, 7 of 21, and 5 of 21 dogs as normocoagulable, hypercoagulable, and hypocoagulable, respectively. G and MA were correlated with fibrinogen (r = 0.68, 0.83), prothrombin time (PT; r = -0.51, -0.53), and activated partial thromboplastin time (aPTT; r = -0.50, -0.50). K was correlated with PT (r = 0.75) and protein C activity (r = -0.92). Angle was correlated with aPTT (r = -0.63). Clinical score was correlated with PT (r = 0.60), MA (r = -0.53), and R (r = -0.47). Dogs with hyperfibrinolysis (LY30 > 3.04%; 5 of 21) had significantly higher serum transaminase activities. Dogs with portal hypertension had significantly lower G, MA, and angle and prolonged, K, R, and PT.
  
  
  CONCLUSIONS
  Dogs with CH have variable TEG results. Negative prognostic indicators in CH correlate with hypocoagulable parameters on TEG. Hyperfibrinolysis in dogs with CH is associated with high disease activity.
authors.affiliation: Massachusetts Veterinary Referral Hospital, Woburn, MA.
authors.forename: W
authors.initials: W
authors.lastname: Fry
authors.affiliation: Ocean State Veterinary Specialists, East Greenwich Rhode Island.
authors.forename: C
authors.initials: C
authors.lastname: Lester
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: N M
authors.initials: NM
authors.lastname: Etedali
authors.affiliation: Department of Clinical Science, Cummings School of Veterinary Medicine at Tufts University, Grafton, MA.
authors.forename: S
authors.initials: S
authors.lastname: Shaw
authors.affiliation: Department of Clinical Science, Cummings School of Veterinary Medicine at Tufts University, Grafton, MA.
authors.forename: A
authors.initials: A
authors.lastname: DeLaforcade
authors.affiliation: Department of Clinical Science, Cummings School of Veterinary Medicine at Tufts University, Grafton, MA.
authors.forename: C R L
authors.initials: CR
authors.lastname: Webster
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D001780:Blood Coagulation Tests / Q000379:methods / Q000662:veterinary; D002908:Chronic Disease; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D008107:Liver Diseases / Q000097:blood / Q000150:complications / Q000662:veterinary*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D013916:Thrombelastography / Q000379:methods / Q000662:veterinary
keywords: Coagulation; Fibrinolysis; Hemostasis; Liver