title: Use of biomarkers in pediatric sepsis: literature review.
abstract: Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.
authors.affiliation: Instituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.|Universidade Federal do Rio de Janeiro - Rio de Janeiro (RJ), Brasil.
authors.forename: Vanessa Soares
authors.initials: VS
authors.lastname: Lanziotti
authors.affiliation: NOVA Medical School, Universidade Nova de Lisboa - Lisboa, Portugal.|Unidade de Cuidados Intensivos Polivalente, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental - Lisboa, Portugal.
authors.forename: Pedro
authors.initials: P
authors.lastname: Póvoa
authors.affiliation: Instituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.
authors.forename: Márcio
authors.initials: M
authors.lastname: Soares
authors.affiliation: Universidade Federal do Rio de Janeiro - Rio de Janeiro (RJ), Brasil.
authors.forename: José Roberto Lapa E
authors.initials: JR
authors.lastname: Silva
authors.affiliation: Instituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.|Unidade de Cuidados Intensivos Polivalente, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental - Lisboa, Portugal.
authors.forename: Arnaldo Prata
authors.initials: AP
authors.lastname: Barbosa
authors.affiliation: Instituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.
authors.forename: Jorge Ibrain Figueira
authors.initials: JI
authors.lastname: Salluh
mesh_terms: D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D006801:Humans; D007223:Infant; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers