title: Seminal Tract Amyloidosis: Synchronous Amyloidosis of the Seminal Vesicles, Deferent Ducts and Ejaculatory Ducts.
abstract: Senile Seminal Vesicle Amyloidosis (SSVA) increases with age. Involvement of the whole seminal tract, i.e. the seminal vesicles, ejaculatory and deferent ducts was first reported by us in the International Symposium on Amyloidosis 1998. Since then we encountered four more cases of SSVA. In all these cases the ejaculatory and deferent ducts were also involved by amyloid. The amyloid was located mostly sub-epithelially, stained positively with Congo red, gave green birefringence under polarized light and was permanganate sensitive, slightly positive for lactoferrin immunostaining and negative for all known amyloid types. In recent years the amyloid was found to be derived from Semenogelin I, a major constituent of the seminal fluid which is present in the epithelial cells of the seminal vesicle and vas deference. This would explain the deposition of amyloid not only in the seminal vesicles but also in the deferent an ejaculatory ducts which transport the seminal fluid. In a review of the literature we found three more articles on SSVA in which the amyloid was not limited to the seminal vesicles alone. We propose to designate this type of amyloid as "Senile seminal Tract Amyloidosis" (SSTA) instead of "Senile Seminal Vesicle Amyloidosis (SSVA)".
authors.affiliation: Department of Pathology Hasharon Hospital, Petah-Tiqva, Israel.|Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Lea
authors.initials: L
authors.lastname: Rath-Wolfson
authors.affiliation: Medicine Program, St. George's University of London, University of Nicosia, 93 Agiou Nikolau Street, Egnomi 2408, Nicosia, Cyprus. bubisgolan@gmail.com.
authors.forename: Golan
authors.initials: G
authors.lastname: Bubis
authors.affiliation: Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Shtrasburg
authors.affiliation: Department of Urology, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Asaf
authors.initials: A
authors.lastname: Shvero
authors.affiliation: Department of Pathology Hasharon Hospital, Petah-Tiqva, Israel.|Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Rumelia
authors.initials: R
authors.lastname: Koren
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000473:pathology*; D004543:Ejaculatory Ducts / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012669:Seminal Vesicles / Q000473:pathology*; D014649:Vas Deferens / Q000473:pathology*
keywords: Ejaculatory duct amyloidosis; Senile seminal tract amyloidosis (SSTA); Senile seminal vesicle amyloidosis (SSVA); Spermatic duct amyloidosis