title: One Ring to Fight Them All: The Sulfazecin Story.
abstract: In this issue of Cell Chemical Biology, Li et al. (2017) report on the biosynthesis of the monobactam sulfazecin by Pseudomonas acidophila and hypothesize a novel mechanism of β-lactam ring formation. As monobactam antibiotics are unaffected by some emerging resistance mechanisms (particularly metallo-β-lactamases), this discovery opens prospects to engineer β-lactam antibiotics against multi-drug resistant pathogens.
authors.affiliation: Junior Research Group Synthetic Microbiology, Friedrich Schiller University at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstr.11a, 07745 Jena, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Braga
authors.affiliation: Junior Research Group Synthetic Microbiology, Friedrich Schiller University at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstr.11a, 07745 Jena, Germany. Electronic address: gerald.lackner@uni-jena.de.
authors.forename: Gerald
authors.initials: G
authors.lastname: Lackner
mesh_terms: D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D015394:Molecular Structure; D008997:Monobactams / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D011549:Pseudomonas / Q000378:metabolism*; D047090:beta-Lactams / Q000378:metabolism
chemical_list: D008997:Monobactams; D047090:beta-Lactams; C028547:sulfazecin