title: MDM2 gene polymorphisms and risk of classic Kaposi's sarcoma among Iranian patients.
abstract: A single-nucleotide polymorphism (SNP) in the promoter region of MDM2 (SNP309T>G, rs2279744) has been shown to increase the expression of the MDM2 protein in various cancer types. However, only one study has analyzed the role of the MDM2 polymorphism in the development of Kaposi's sarcoma (KS). The association of MDM2 SNP309 with classic KS risk was evaluated in 79 Iranian patients with classic KS and 123 healthy controls. The MDM2 SNP309 was genotyped using PCR and restriction fragment length polymorphism methods. No significant correlation was found between the SNP309 polymorphism in MDM2 promoter and classic KS risk. There was no significant correlation between gender and disease stage. However, a significant association was found between SNP309 GG genotype and younger age (≤50 years) (odds ratio 9.5, 95% confidence intervals 1.5-60, p = 0.03). Our findings support no major role for the MDM2 SNP309 in KS development although it might influence the clinical outcome of KS in younger patients.
authors.affiliation: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran.
authors.forename: Sajad
authors.initials: S
authors.lastname: Varmazyar
authors.affiliation: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran.
authors.forename: Sayed Mahdi
authors.initials: SM
authors.lastname: Marashi
authors.affiliation: Department of Virology, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Zabihollah
authors.initials: Z
authors.lastname: Shoja
authors.affiliation: Molecular Biology and Viral Oncology Division, Department of Research, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Napoli, Italy.
authors.forename: Maria Lina
authors.initials: ML
authors.lastname: Tornesello
authors.affiliation: Molecular Biology and Viral Oncology Division, Department of Research, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Napoli, Italy.
authors.forename: Franco M
authors.initials: FM
authors.lastname: Buonaguro
authors.affiliation: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran.|Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahmahmoodi
authors.affiliation: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Safaie-Naraghi
authors.affiliation: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran. sjalilvand@tums.ac.ir.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Jalilvand
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D016679:Genome, Viral; D005838:Genotype; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012306:Risk; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000235:genetics* / Q000821:virology
chemical_list: D051736:Proto-Oncogene Proteins c-mdm2
keywords: Kaposi’s sarcoma; MDM2; Risk factor; Single-nucleotide polymorphism