title: MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes.
abstract: Gestational diabetes mellitus (GDM) is glucose intolerance detected during pregnancy. The MTNR1B gene is the genetic locus associated with type 2 diabetes, that may affect insulin secretion and pancreatic glucose sensing. In this study, we examined the association between MTNR1A (rs2119882) and MTNR1B (rs10830963, rs4753426) gene polymorphisms and the risk of GDM. According to the results of their oral glucose tolerance test (OGTT), the women were divided into two groups: 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). There were no statistically significant differences in the distribution of MTNR1A rs2119882 and MTNR1B rs4753426 genotypes and alleles between women with GDM and healthy pregnant women. With regard to the MTNR1B rs10830963 polymorphism, we observed a statistically significant prevalence of GG and CG genotypes and the G allele among pregnant women with GDM (GG + CG vs CC, OR 1.50, 95% CI 1.02-2.22, p = 0.04; G vs C, OR 1.43, 95% CI 1.07-1.90, p = 0.016). In a multivariate logistic regression analysis, a higher number of MTNR1B rs10830963 G alleles was an independent significant predictor of a higher risk of GDM. The results of our study indicate that MTNR1B rs10830963 polymorphism is associated with GDM susceptibility, and women with a higher number of G alleles have an increased risk of GDM development.
authors.affiliation: a Department of Physiology , Pomeranian Medical University , Szczecin , Poland and.
authors.forename: Maciej
authors.initials: M
authors.lastname: Tarnowski
authors.affiliation: a Department of Physiology , Pomeranian Medical University , Szczecin , Poland and.
authors.forename: Damian
authors.initials: D
authors.lastname: Malinowski
authors.affiliation: b Department of Biochemistry and Medical Chemistry , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.affiliation: b Department of Biochemistry and Medical Chemistry , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.affiliation: a Department of Physiology , Pomeranian Medical University , Szczecin , Poland and.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
mesh_terms: D000328:Adult; D001786:Blood Glucose; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005951:Glucose Tolerance Test; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D044122:Receptor, Melatonin, MT1 / Q000235:genetics*; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; C000610981:MTNR1A protein, human; C573871:MTNR1B protein, human; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2
keywords: Gestational diabetes; melatonin receptors; polymorphisms