title: Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence.
abstract: Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. This review will highlight the current progress in PpIX-mediated FGR and discuss technical challenges in intraoperative quantification of intracellular PpIX fluorescence during FGR of brain tumor.
authors.affiliation: Fujian Normal University , MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, 8 Shangsan Road, Fuzhou 350007, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Fujian Medical University , Union Hospital, Department of Neurosurgery, 29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Songsheng
authors.initials: S
authors.lastname: Shi
authors.affiliation: Chinese PLA General Hospital , Department of Laser Medicine, 28 Fuxing Road, Beijing 100039, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Affiliated Hospital of Academy of Military Medical Sciences , Department of Neurosurgery, 8 Dongda Avenue, Beijing 100071, China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Li
authors.affiliation: Fujian Normal University , MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, 8 Shangsan Road, Fuzhou 350007, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zou
authors.affiliation: The Second Affiliated Hospital of Harbin Medical University , Department of Neurosurgery, 246 Xuefu Road, Harbin 150001, China.
authors.forename: Shaoshan
authors.initials: S
authors.lastname: Hu
keywords: aminolevulinic acid; brain tumor; fluorescence; fluorescence-guided resection; protoporphyrin IX; quantification