title: The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents.
abstract: This study aimed to determine antiradical (DPPH•and•OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against•OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
authors.affiliation: a Faculty of Sciences, Department of Biology and Ecology.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Janjušević
authors.affiliation: a Faculty of Sciences, Department of Biology and Ecology.
authors.forename: Maja
authors.initials: M
authors.lastname: Karaman
authors.affiliation: b Department of Chemistry and Biochemistry , University of Novi Sad , Novi Sad , Serbia.
authors.forename: Filip
authors.initials: F
authors.lastname: Šibul
authors.affiliation: c CNR-ICB , National Research Council of Italy, Institute of Biomolecular Chemistry , Pozzuoli (Naples) , Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Tommonaro
authors.affiliation: c CNR-ICB , National Research Council of Italy, Institute of Biomolecular Chemistry , Pozzuoli (Naples) , Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Iodice
authors.affiliation: d Centre of Chemistry , Institute of Chemistry, Technology and Metallurgy, University of Belgrade , Belgrade , Serbia.
authors.forename: Dragica
authors.initials: D
authors.lastname: Jakovljević
authors.affiliation: e Department of Life Sciences , Institute for Multidisciplinary Research - IMSI, University of Belgrade , Belgrade , Serbia.
authors.forename: Boris
authors.initials: B
authors.lastname: Pejin
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D016166:Free Radical Scavengers / Q000494:pharmacology*; D053719:Tandem Mass Spectrometry; D055454:Trametes / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D016166:Free Radical Scavengers; D000110:Acetylcholinesterase
keywords: AChE inhibitory activity; Alzheimer’s disease; Trametes versicolor; anti •OH activity; water extract