title: Regional and subcellular distribution of GABACρ3 receptor in brain of R6/2 mouse model of Huntington's disease.
abstract: In the present study, we describe the distribution of GABACρ3 receptor immunoreactivity in the cortex, striatum and hippocampus of wild type (wt) and 11 weeks old HD transgenic (tg) R6/2 mouse brain. In the brain of wt mice, GABACρ3 immunoreactivity is well expressed in neuronal cells, nerve fibers and axonal processes. In comparison to wt, GABACρ3 receptor like immunoreactivity decreases significantly in all three brain regions of R6/2 mice. The altered distributional pattern and significant changes in GABACρ3 receptor immunoreactivity as seen in the R6/2 mouse brain might be a plausible molecular mechanism for excitotoxicity in HD pathogenesis due to the loss of inhibitory input.
authors.affiliation: Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada. Electronic address: ujkumar@mail.ubc.ca.
authors.forename: Ujendra
authors.initials: U
authors.lastname: Kumar
authors.affiliation: Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Heer
authors.affiliation: Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
authors.forename: Rishi K
authors.initials: RK
authors.lastname: Somvanshi
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006816:Huntington Disease / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism*; D009928:Organ Specificity; D018079:Receptors, GABA / Q000378:metabolism*
chemical_list: C000624191:GABA-C rho3 receptor, mouse; D018079:Receptors, GABA
keywords: Central nervous system; GABA; GABA(C) ρ3 receptor; Huntington’s disease; Immunohistochemistry; R6/2 mice