title: A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescencein situhybridization.
abstract: Acute promyelocytic leukemia (APL) is typified by t(15;17)(q22;q21), generating the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The PML-RARA fusion gene is believed to play a vital role in leukemogenesis. A sizeable minority of patients with complex variants of APL have been reported. The present study reports the case of a 33-year-old male with APL carrying a potential complex translocation. The initial symptom was bleeding gums. Chromosomal analysis of the bone marrow cells revealed an atypical 17q aberration. Fluorescencein situhybridization further indicated that 92% of analyzed cells were positive for the PML-RARA fusion gene. The patient experienced complete remission following treatment with arsenic trioxide and chemotherapy. The atypical translocations in acute promyelocytic leukemia require further investigation.
authors.affiliation: Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China; Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Xinguang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
authors.forename: Riming
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
authors.forename: Jiannong
authors.initials: J
authors.lastname: Cen
authors.affiliation: Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Chu
keywords: acute promyelocytic leukemia; complex translocation; t(3,15,17)