title: Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord.
abstract: Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography. Treatment with L-NAME during the acute period of traumatic injury to the spinal cord sharply reduced the intensity of evoked motor responses and more pronounced increase in excitability of peripheral motor structures. The results suggest that NO system is a factor of regulation of the stress-induced and adaptive responses of the body at the early stage of spinal cord injury.
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia.|Republican Clinical Hospital, Ministry of Health of Tatarstan Republic, Kazan, Russia.|Kazan Physical-Technical Institute, Kazan Research Center of the Russian Academy of Sciences, Kazan, Tatarstan Republic, Russia.
authors.forename: G G
authors.initials: GG
authors.lastname: Yafarova
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia.|Kazan Physical-Technical Institute, Kazan Research Center of the Russian Academy of Sciences, Kazan, Tatarstan Republic, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Andrianov
authors.affiliation: Republican Clinical Hospital, Ministry of Health of Tatarstan Republic, Kazan, Russia.
authors.forename: R Kh
authors.initials: RK
authors.lastname: Yagudin
authors.affiliation: Republican Clinical Hospital, Ministry of Health of Tatarstan Republic, Kazan, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Shaikhytdinov
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia. kh_gainutdinov@mail.ru.|Kazan Physical-Technical Institute, Kazan Research Center of the Russian Academy of Sciences, Kazan, Tatarstan Republic, Russia. kh_gainutdinov@mail.ru.
authors.forename: Kh L
authors.initials: KL
authors.lastname: Gainutdinov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D004576:Electromyography; D004578:Electron Spin Resonance Spectroscopy; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D013119:Spinal Cord Injuries / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; D019331:NG-Nitroarginine Methyl Ester
keywords: L-NAME blocker; electron paramagnetic resonance; electroneuromyography; nitrogen oxide; spinal cord