title: Coumarin to Isocoumarin: One-Pot Synthesis of 3-Substituted Isocoumarins from 4-Hydroxycoumarins and Benzyne Precursors.
abstract: A novel transition-metal-free direct synthesis of 3-substituted isocoumarin from 4-hydroxycoumarin and a benzyne precursor is developed. This synthetic strategy proceeds via C-O and C-C bond cleavage as well as C-O and C-C bond formations in a single reaction vessel by simple treatment with CsF in the absence of catalyst. This methodology affords moderate to good yields of 3-substituted isocoumarins and is tolerant of a variety of functional groups including halide.
authors.affiliation: Applied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology , Jorhat 785006, India.
authors.forename: Kashmiri
authors.initials: K
authors.lastname: Neog
authors.affiliation: Applied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology , Jorhat 785006, India.
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Dutta
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
authors.forename: Babulal
authors.initials: B
authors.lastname: Das
authors.affiliation: Applied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology , Jorhat 785006, India.
authors.forename: Pranjal
authors.identifier: 0000-0003-0711-0328
authors.initials: P
authors.lastname: Gogoi