title: Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes.
abstract: Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixed meal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with15O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with presurgery, the mixed meal induced a greater increase in plasma glucose, insulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of pancreatic and intestinal BF responses. GIP infusion decreased pancreatic but increased small intestinal BF similarly in all groups both before and after surgery. Taken together, these results demonstrate that bariatric surgery leads to enhanced splanchnic vascular responses as a likely consequence of rapid glucose appearance and GIP hypersecretion.
authors.affiliation: Turku PET Centre, University of Turku, Turku, Finland.
authors.forename: Henri
authors.initials: H
authors.lastname: Honka
authors.affiliation: Turku PET Centre, University of Turku, Turku, Finland.|Department of Gastroenterology, Turunmaa Hospital, Turku, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Koffert
authors.affiliation: Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.
authors.forename: Saila
authors.initials: S
authors.lastname: Kauhanen
authors.affiliation: Turku PET Centre, University of Turku, Turku, Finland.
authors.forename: Jarmo
authors.initials: J
authors.lastname: Teuho
authors.affiliation: Department of Biostatistics, University of Turku, Turku, Finland.
authors.forename: Saija
authors.initials: S
authors.lastname: Hurme
authors.affiliation: Institute of Neuroscience, National Research Council, Padua, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mari
authors.affiliation: Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lindqvist
authors.affiliation: Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.
authors.forename: Nils
authors.initials: N
authors.lastname: Wierup
authors.affiliation: Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.
authors.forename: Leif
authors.initials: L
authors.lastname: Groop
authors.affiliation: Turku PET Centre, University of Turku, Turku, Finland pirjo.nuutila@utu.fi.|Department of Endocrinology, Turku University Hospital, Turku, Finland.
authors.forename: Pirjo
authors.initials: P
authors.lastname: Nuutila
mesh_terms: D050110:Bariatric Surgery; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007422:Intestines / Q000098:blood supply; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D010104:Oxygen Radioisotopes; D010179:Pancreas / Q000098:blood supply; D049268:Positron-Emission Tomography; D019518:Postprandial Period; D013152:Splanchnic Circulation / Q000187:drug effects / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010104:Oxygen Radioisotopes; D005749:Gastric Inhibitory Polypeptide