title: Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions.
abstract: The aim of this study was to evaluate retinal and choriocapillaris vessel density using optical coherence tomography angiography (OCTA) in eyes with central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) complicated by macular edema (ME). Sixty eyes of 60 patients with CRVO or BRVO and ME and 40 healthy subjects underwent measurements of superficial and deep foveal and parafoveal vessel density (FVD, PFVD) and choricapillary density using OCTA at baseline and 60 days after intravitreal dexamethasone implant (IVDEX). FVD and PFVD of the superficial plexus were not significantly lower in CRVO group compared to the controls while in the BRVO group overall PFVD were significantly lower compared to control group (p < 0.001). Overall PFVD of the deep plexus was significantly lower in CRVO and BRVO groups compared to the control group (p < 0.001). FVD and overall PFVD of choriocapillaris were significantly reduced compared to controls in CRVO group (p < 0.001) and PFVD of choriocapillaris was significantly reduced compared to controls in the affected hemi fields in BRVO groups (p < 0.001). OCTA showed vessel density reduction in BRVO and CRVO with main involvement of the deep retinal plexus compared to the superficial retinal plexus due to ischemia that did not recover after intravitreal dexamethasone implant.
authors.affiliation: Ophthalmology Clinic, Moorfields Eye Hospital, London, EC1V 2PD, UK.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mastropasqua
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, 66100, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Toto
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, 66100, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Di Antonio
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, 66100, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Borrelli
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, 66100, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Senatore
authors.affiliation: Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, Chieti, 66100, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Di Nicola
authors.affiliation: Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, Chieti, 66100, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Martino
authors.affiliation: Ophthalmology Clinic, University of l'Aquila, Aquila, 67100, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ciancaglini
authors.affiliation: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, 66100, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Carpineto