title: Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging.
abstract: BACKGROUND
  The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. OCTA images were analyzed for alterations in retinochoroidal microvasculature.
  
  
  RESULTS
  Thirty-four eyes (24 patients; 10 with VKH and 14 with CSC) were included. OCTA en face images showed apparent areas of choriocapillaris flow void due to shadowing effect from overlying subretinal fluid and pigment epithelial detachment in CSC. However, eyes with VKH showed presence of true choriocapillaris flow void on OCTA that corresponded to choriocapillaris ischemia on ICGA.
  
  
  CONCLUSIONS
  OCTA is a useful tool to assess choriocapillaris ischemia in VKH and is helpful to differentiate it from CSC in the acute stage.
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
authors.forename: Kanika
authors.initials: K
authors.lastname: Aggarwal
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.|Ocular Imaging Research and Reading Center (OIRRC), Omaha, NE, 68105, USA.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
authors.forename: Ankit
authors.initials: A
authors.lastname: Deokar
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
authors.forename: Sarakshi
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Singh
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
authors.forename: Reema
authors.initials: R
authors.lastname: Bansal
authors.affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
authors.forename: Aman
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
authors.forename: Mangat R
authors.initials: MR
authors.lastname: Dogra
authors.affiliation: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India. vishalisara@yahoo.co.in.
authors.forename: Vishali
authors.initials: V
authors.lastname: Gupta
keywords: Central serous chorioretinopathy; EDI-OCT; Indocyanine green angiography; Multimodal imaging; Optical coherence tomography angiography; Vogt-Koyanagi-Harada syndrome