title: Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report.
abstract: Although everolimus, a mammalian target of rapamycin inhibitor, has been used as a potent immunosuppressive agent in organ transplantation, data regarding its adverse effect profile compared with that of sirolimus in clinical circumstances are limited. A 50-year-old man who underwent simultaneous liver and kidney transplantation 14 months previously was admitted with large pleural effusion, pericardial effusion, and ascites. Laboratory findings and cultures for possible infectious causes were all negative. Pericardial window surgery with drainage of the pericardial fluid was performed on day 3. Pleural and pericardial biopsy revealed non-specific inflammation without evidence of malignant cells. Everolimus was discontinued and replaced by mycophenolate mofetil on day 4. Significant clinical improvement was observed after discontinuation of everolimus, and follow-up echocardiography and chest radiography showed no recurrence of the pericardial or pleural effusion after discharge.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: K
authors.initials: K
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: D W
authors.initials: DW
authors.lastname: Jeong
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Y G
authors.initials: YG
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: K-H
authors.initials: KH
authors.lastname: Jeong
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: T W
authors.initials: TW
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: C-G
authors.initials: CG
authors.lastname: Ihm
authors.affiliation: Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Joo
authors.affiliation: Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: H-C
authors.initials: HC
authors.lastname: Park
authors.affiliation: Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea. Electronic address: lshkidney@khu.ac.kr.
authors.forename: S-H
authors.initials: SH
authors.lastname: Lee
mesh_terms: D001201:Ascites / Q000139:chemically induced; D003928:Diabetic Nephropathies / Q000150:complications; D004322:Drainage; D004452:Echocardiography; D000068338:Everolimus / Q000009:adverse effects*; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010493:Pericarditis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D010996:Pleural Effusion / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010998:Pleurisy / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012700:Serositis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D016559:Tacrolimus / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents; D000068338:Everolimus; D011239:Prednisolone; D016559:Tacrolimus