title: Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents.
abstract: A supramolecular, polymer-dot-based ensemble has been developed for the ratiometric detection of lectins and targeted delivery of glycoprobes. Self-assembly between a blue-emitting polymer dot and a red-emitting glycoprobe, results in an ensemble that shows red emission upon excitation of the polymer dot because of Förster resonance energy transfer. Resulting in ratiometric detection of lectins in buffer solution as well as targeted delivery of the glycoprobe to cells that highly express a sugar receptor. Unlike conventional systems where both the agent and vector are codelivered intracellularly, our ensemble developed here shows a receptor-controlled dissociation on the cell membrane.
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Chang-Zheng
authors.initials: CZ
authors.lastname: Wang
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.|National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shoujing Road, Shanghai 201203, PR China.
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Chen
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University , Changchun 130012, PR China.
authors.forename: Ying
authors.identifier: http://orcid.org/0000-0002-1105-9003
authors.initials: Y
authors.lastname: Tang
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shoujing Road, Shanghai 201203, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zang
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of Bath , Bath BA2 7AY, United Kingdom.
authors.forename: Tony D
authors.identifier: http://orcid.org/0000-0002-4095-2191
authors.initials: TD
authors.lastname: James
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shoujing Road, Shanghai 201203, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University , Changchun 130012, PR China.
authors.forename: Changfeng
authors.initials: C
authors.lastname: Wu
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: He
mesh_terms: D002352:Carrier Proteins; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes; D037102:Lectins; D011108:Polymers / Q000737:chemistry*
chemical_list: D002352:Carrier Proteins; D005456:Fluorescent Dyes; D037102:Lectins; D011108:Polymers
keywords: cell imaging; glycoprobe; polymer dot; probe; ratiometric