title: Signal replication in a DNA nanostructure.
abstract: Logic circuits based on DNA strand displacement reaction are the basic building blocks of future nanorobotic systems. The circuits tethered to DNA origami platforms present several advantages over solution-phase versions where couplings are always diffusion-limited. Here we consider a possible implementation of one of the basic operations needed in the design of these circuits, namely, signal replication. We show that with an appropriate preparation of the initial state, signal replication performs in a reproducible way. We also show the existence of side effects concomitant to the high effective concentrations in tethered circuits, such as slow leaky reactions and cross-activation.
authors.affiliation: CBMN, UMR 5248, CNRS, Allée St Hilaire, Bât. B14, 33600 Pessac, France.
authors.forename: Oscar
authors.initials: O
authors.lastname: Mendoza
authors.affiliation: CBMN, UMR 5248, CNRS, Allée St Hilaire, Bât. B14, 33600 Pessac, France.
authors.forename: Said
authors.initials: S
authors.lastname: Houmadi
authors.affiliation: CBMN, UMR 5248, CNRS, Allée St Hilaire, Bât. B14, 33600 Pessac, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Aimé
authors.affiliation: CBMN, UMR 5248, CNRS, Allée St Hilaire, Bât. B14, 33600 Pessac, France.
authors.forename: Juan
authors.initials: J
authors.lastname: Elezgaray
mesh_terms: D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D004867:Equipment Design; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry; D049329:Nanostructures; D009693:Nucleic Acid Hybridization
chemical_list: D005456:Fluorescent Dyes; D004247:DNA