title: Investigation of the Tiger Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes), as an Antiulcer Agent.
abstract: The aim of this study was to determine the antiulcer activity of Lignosus rhinocerotis in rats. A total of 48 Sprague-Dawley rats were used in ethanol-induced, aspirin-induced, and water immersion-restraint stress-induced ulcer models. Rats were equally divided into 4 groups for each model and orally administered 5 mL/kg distilled water, 20 mg/kg omeprazole, as well as 250 and 500 mg/kg of L. rhinocerotis powder. L. rhinocerotis powder at both 250 and 500 mg/kg doses demonstrated significant (P < 0.05) protection against gastric ulceration in all the induced ulcer models. Histological studies revealed severe damage and hemorrhage of gastric mucosa in the negative control group for all ulcer-induced models. The study suggests that L. rhinocerotis powder possesses dose-dependent antiulcer activity in the gastric mucosa, as ascertained grossly and histologically, compared with the negative control groups.
authors.affiliation: Department of Food Science with Nutrition, Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia.
authors.forename: Kar Lin
authors.initials: KL
authors.lastname: Nyam
authors.affiliation: Department of Food Science with Nutrition, Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia.
authors.forename: Chia Yoong
authors.initials: CY
authors.lastname: Chang
authors.affiliation: Malaysian Agricultural Research and Development Institute (MARDI), Selangor, Malaysia.
authors.forename: Chon Seng
authors.initials: CS
authors.lastname: Tan
authors.affiliation: Ligno Biotech Sdn. Bhd., Balakong Jaya, Selangor, Malaysia.
authors.forename: Szu Ting
authors.initials: ST
authors.lastname: Ng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D004032:Diet / Q000379:methods*; D008297:Male; D011124:Polyporaceae; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents