title: Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms.
abstract: Heat stroke is characterized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose of quercetin (30 mg/kg) or vehicle (normal saline 1 ml/kg) was administered to the experimental groups of rats. Additional injection was administered immediately after the onset of heat stroke. Immediately after the onset of heat stroke. Vehicle-treated rats displayed (i) hyperthermia; (ii) suppressed left ventricular function; (iii) decreased contents of cardiac total antioxiant capacity (e.g., superoxide dismutase, glutathione peroxidase, catalase); (iv) increased contents of cardiac oxidative capacity malondialdehyde and thiobarbituric acid reactive substances; (v) increased cardiac levels of pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6; and (vi) decreased cardiac levels of an anti-inflammatory cytokine interleukin 10. Histopathologic and survival observation provided supportive evidence for biochemical analyses. These heat stroke reactions all can be significantly attenuated by quercetin therapy. Our data suggest that quercetin therapy might improve outcomes of heat stroke in rats by attenuating excessive hyperthermia as well as myocardial injury. The protective effects of quercetin could be attributed to anti-lipid peroxidative, anti-oxidant, and anti-inflammatory properties.
authors.affiliation: Department of Spinal Cord Injury and Repair, Trauma and Orthopedics, Institute of Chinese PLA, General Hospital of Jinan Military Region, Shandong, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Leisure and Tourism Management, Southern Taiwan University of Science and Technology, Tainan, Taiwan, ROC.
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Orthopedics, Shandong Cancer Hospital, Shandong University, Shandong, China. Electronic address: doctorzhaotingbao@163.com.
authors.forename: Tingbao
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Trauma and Orthopedics Center of Chinese PLA, General Hospital of Guangzhou Military Region, Guangdong Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zuo
authors.affiliation: Trauma and Orthopedics Center of Chinese PLA, General Hospital of Guangzhou Military Region, Guangdong Province, China.
authors.forename: Zhujun
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Sanatorium of Guangzhou Military Region, Guangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan, ROC. Electronic address: 891201@mail.chimei.org.tw.
authors.forename: Mao-Tsun
authors.initials: MT
authors.lastname: Lin
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D016207:Cytokines / Q000378:metabolism; D018883:Heat Stroke / Q000150:complications*; D006439:Hemodynamics; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D011794:Quercetin
keywords: Heat stroke; Inflammation; Myocardial injury; Oxidative stress; Quercetin