title: Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination.
abstract: Genetic and environmental factors, i.e. infections, have been proposed to contribute to disease induction and relapsing events in multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system (CNS). While research has mainly focused on virus associated autoimmune activation, less is known about prevention of autoimmunity, especially following resolving infections associated with CNS tissue damage. This review discusses novel insights on control of self-reactive (SR) T cells activated during neurotropic coronavirus-induced demyelination. A new concept is introduced that SR T cells can be dampened by distinct regulatory mechanisms in the periphery and the CNS, thereby preventing autoimmune disease.
authors.affiliation: Lerner Research Institute, Cleveland Clinic, Neuroscience Department NC-30, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: savaric@ccf.org.
authors.forename: Carine
authors.initials: C
authors.lastname: Savarin
authors.affiliation: Lerner Research Institute, Cleveland Clinic, Neuroscience Department NC-30, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Cornelia C
authors.initials: CC
authors.lastname: Bergmann
mesh_terms: D000818:Animals; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D017934:Coronavirus / Q000472:pathogenicity; D018352:Coronavirus Infections / Q000150:complications*; D003711:Demyelinating Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology; D006801:Humans; D008213:Lymphocyte Activation
keywords: Central nervous system (CNS); Multiple sclerosis; Regulatory T cells; Self-reactive (SR) CD4 T cells; Virus