title: Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence: A Pooled Analysis.
abstract: No studies have evaluated the association between the dietary inflammatory index (DII) and colorectal adenoma recurrence. DII scores were calculated from a baseline food frequency questionnaire. Participants (n = 1727) were 40-80 years of age, enrolled in two Phase III clinical trials, who had ≥1 colorectal adenoma(s) removed within 6 months of study registration, and a follow-up colonoscopy during the trial. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). No statistically significant associations were found between DII and odds of colorectal adenoma recurrence [ORs (95% CIs) = 0.93 (0.73, 1.18) and 0.95 (0.73, 1.22)] for subjects in the second and third DII tertiles, respectively, compared to those in the lowest tertile (Ptrend= 0.72). No associations were found for recurrent colorectal adenoma characteristics, including advanced recurrent adenomas, large size, villous histology, or anatomic location. While our study did not support an association between a proinflammatory diet and colorectal adenoma recurrence, future studies are warranted to elucidate the role of a proinflammatory diet on the early stages of colorectal carcinogenesis.
authors.affiliation: a Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , New York , USA.|b Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center , New York , New York , USA.|c Department of Occupational Medicine, Epidemiology, and Prevention , Hofstra Northwell School of Medicine , Hempstead , New York , USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Sardo Molmenti
authors.affiliation: d Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.|e Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Steck
authors.affiliation: f University of Arizona Cancer Center , Tucson , Arizona , USA.|g Mel and Enid Zuckerman College of Public Health, University of Arizona , Tucson , Arizona , USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Thomson
authors.affiliation: h Department of Preventive Medicine , Feinburg School of Medicine, Northwestern University , Chicago, Illinois , USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Hibler
authors.affiliation: a Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , New York , USA.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.affiliation: d Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.|e Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.|i Connecting Health Innovations , LLC , Columbia , South Carolina , USA.
authors.forename: N
authors.initials: N
authors.lastname: Shivappa
authors.affiliation: a Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , New York , USA.|b Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center , New York , New York , USA.
authors.forename: H
authors.initials: H
authors.lastname: Greenlee
authors.affiliation: d Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.|e Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.|i Connecting Health Innovations , LLC , Columbia , South Carolina , USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Wirth
authors.affiliation: a Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , New York , USA.|b Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center , New York , New York , USA.
authors.forename: A I
authors.initials: AI
authors.lastname: Neugut
authors.affiliation: f University of Arizona Cancer Center , Tucson , Arizona , USA.|g Mel and Enid Zuckerman College of Public Health, University of Arizona , Tucson , Arizona , USA.
authors.forename: E T
authors.initials: ET
authors.lastname: Jacobs
authors.affiliation: d Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.|e Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.|i Connecting Health Innovations , LLC , Columbia , South Carolina , USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Hébert
mesh_terms: D000236:Adenoma / Q000209:etiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017326:Clinical Trials, Phase III as Topic; D015179:Colorectal Neoplasms / Q000209:etiology*; D004032:Diet / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D016032:Randomized Controlled Trials as Topic