title: Analgesic effect of quetiapine in a mouse model of cancer-induced bone pain.
abstract: OBJECTIVE
  Cancer-induced bone pain (CIBP) is one of the most common pains in patients with advanced neoplasms. Because of treatment-associated side effects, more than half of cancer patients are reported to have inadequate and undermanaged pain control. New mechanism-based therapies must be developed to reduce cancer pain. Quetiapine is a commonly used atypical antipsychotic drug. We report a study of the potential analgesic effects of quetiapine in a mouse model of CIBP and examine the mechanism of bone pain by analyzing the expression of various nociceptors.
  
  
  METHODS
  Fifteen male C3H/HeN mice were arbitrarily divided into five groups: control and, CIBP with no treatment, quetiapine treatment, opioid treatment, and melatonin treatment. The mice were tested for mechanical hyperalgesia by determining the nociceptive hind paw withdrawal pressure threshold. Tissues from tibia were removed and subjected to quantitative and qualitative evaluations of transient receptor potential vanilloid 1 (TRPV1), TRPV4, acid-sensing ion channel 1 (ASIC1), ASIC2, and ASIC3 expression.
  
  
  RESULTS
  Paw withdrawal pressure threshold was improved in the quetiapine treatment group compared with the CIBP group. Expression of TRPV1, TRPV4, ASIC1, ASIC2, and ASIC3 in the CIBP with quetiapine treatment group was significantly lower than that in the CIBP group.
  
  
  CONCLUSIONS
  Our results suggest an analgesic effect of quetiapine in the CIBP animal model and implicate TRPV and ASICs as potential targets for cancer pain management.
authors.affiliation: Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Mi Hwa
authors.initials: MH
authors.lastname: Heo
authors.affiliation: Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Pathology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Ilseon
authors.initials: I
authors.lastname: Hwang
authors.affiliation: Department of Pain Research Center, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Ha
authors.affiliation: Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.|Department of Keimyung University Kidney Institute, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Keon Uk
authors.initials: KU
authors.lastname: Park
mesh_terms: D062565:Acid Sensing Ion Channels / Q000378:metabolism; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008297:Male; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000150:complications* / Q000378:metabolism; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000069348:Quetiapine Fumarate / Q000627:therapeutic use*
chemical_list: D062565:Acid Sensing Ion Channels; D014150:Antipsychotic Agents; D000069348:Quetiapine Fumarate
keywords: Mice; Neoplasms; Nociceptors; Pain; Quetiapine fumarate