title: Clinical outcomes for couples containing a reciprocal chromosome translocation carrier without preimplantation genetic diagnosis.
abstract: OBJECTIVE
  To evaluate the pregnancy outcomes of couples containing a carrier of a reciprocal chromosome translocation (RCT) after assisted reproductive technology without preimplantation genetic diagnosis.
  
  
  METHODS
  A retrospective study was performed using data for couples with an RCT carrier and control couples with a normal karyotype (1:4 ratio) who underwent assisted reproductive technology cycles at a Chinese fertility center in 2010-2011. The embryos were fertilized via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Only the first pick-up cycles were used for analysis. Clinical variables were compared.
  
  
  RESULTS
  Compared with the control group (n=164), the RCT group (n=41) had a marginally lower clinical pregnancy rate (46.3% [19/41] vs 54.3% [89/164]), implantation rate (21.7% [23/106] vs 26.9% [118/438]), multiple-gestation pregnancy rate (21.1% [4/19] vs 32.6% [29/89]), and delivery rate (36.6% [15/41] vs 47.6% [78/164]), whereas the spontaneous abortion rate was slightly higher (21.1% [4/19] vs 12.4% [11/89]). However, none of these differences were significant.
  
  
  CONCLUSIONS
  The clinical outcomes for RCT carriers were acceptable after IVF/ICSI without performing preimplantation genetic diagnosis, indicating that this approach might comprise a feasible alternative fertility treatment for RCT carriers.
authors.affiliation: The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Yin
authors.affiliation: Shenzhen Key Laboratory for Reproductive Immunology of Preimplantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.|Key Laboratory in Health Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China.
authors.forename: Yuanchang
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Shenzhen Key Laboratory for Reproductive Immunology of Preimplantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
authors.forename: Tonghua
authors.initials: T
authors.lastname: Wu
authors.affiliation: Shenzhen Key Laboratory for Reproductive Immunology of Preimplantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
authors.forename: Shuqiu
authors.initials: S
authors.lastname: Shen
authors.affiliation: Shenzhen Key Laboratory for Reproductive Immunology of Preimplantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Liang
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D002681:China; D005260:Female; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D007246:Infertility / Q000628:therapy*; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple / Q000706:statistics & numerical data*; D019836:Preimplantation Diagnosis; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014178:Translocation, Genetic
keywords: Assisted reproductive technology; Genetic counseling; Karyotype; Preimplantation genetic diagnosis; Reciprocal chromosome translocation