title: Epithelial-mesenchymal transition in tumor metastasis.
abstract: The epithelial-mesenchymal transition (EMT) is a developmental program that enables stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells reactivate EMT to acquire molecular alterations that enable the partial loss of epithelial features and partial gain of a mesenchymal phenotype. Our understanding of the contribution of EMT to tumor invasion, migration, and metastatic outgrowth has evolved over the past decade. In this review, we provide a summary of both historic and recent studies on the role of EMT in the metastatic cascade from various experimental systems, including cancer cell lines, genetic mouse tumor models, and clinical human breast cancer tissues.
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.|Department of Medicine, University of California, San Diego, La Jolla, CA, USA.|Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Kay T
authors.initials: KT
authors.lastname: Yeung
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.|Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.|Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D002465:Cell Movement; D004195:Disease Models, Animal; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology*
keywords: cancer; circulating tumor cells; epithelial-mesenchymal transition; invasion; metastasis; progression