title: [Epidemiological characteristics of children aged 1-4 years without timely birth dose of hepatitis B vaccine vaccination in China, 2014].
abstract: Objective:To evaluate the epidemiological characteristics of the children aged 1-4 years without timely birth dose of hepatitis B vaccine (HepB(1)) vaccination.Methods:Based on the data from 160 disease surveillance points in 31 provinces of China, two-stage cluster random sampling was used to select the target population aged 1-4 years. A standard questionnaire was used to collect the information about the birth date, gender, ethnic group, place of birth, HepB immunization history of the children selected. A blood sample (3 ml) was taken from each subject for HBsAg testing. SAS software (Version 9.4) was used in our study. We analyzed the age, gender, ethnic group, area specific distributions of the children aged 1-4 years without timely HepB(1) vaccination and the influencing factors, and the relationship between the HepB(1) vaccination time and HBsAg prevalence rate.Results:A total of 12 587 children aged 1-4 years were analyzed and the non-timely HepB(1) vaccination rate was 10.12%. The place of birth, ethnic group, urban/rural area, eastern/central/western area, age were the main influencing factor of the non-timely HepB(1) vaccination. The non-timely HepB(1) vaccination rate was higher in 3-4 years old children (11.13%) than in 1-2 years old children (8.97%), in rural area (12.05%) than in urban area (8.19%), in western area (13.41%) than in central area (9.27%) and eastern area (7.72%), in minority ethnic group (18.06%) than in Han ethnic group (8.77%) and in children born outside hospital (57.66%) than in children born in hospital (9.27%). The HBsAg prevalence rate among 1-4 years children was 0.31%. The HBsAg prevalence rate of the children with timely HepB(1) vaccination (0.25%) was lower than that of the children without timely HepB(1) vaccination (0.89%).Conclusions:In China, the HBsAg prevalence rate among 1-4 years children with HepB vaccination decreased to <0.5%and the timely HepB(1) vaccination rate reached to 90%. We should strengthen the timely HepB(1) vaccination for the children in minority ethnic groups, in western area, in rural area as well as those born outside hospitals.
authors.affiliation: Division 2 of Epidemiology, National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Wang
authors.affiliation: Division 2 of Epidemiology, National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: G M
authors.initials: GM
authors.lastname: Zhang
authors.affiliation: National Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Shen
authors.affiliation: Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Division 2 of Epidemiology, National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: H
authors.initials: H
authors.lastname: Zheng
authors.affiliation: National Institute of Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Division 2 of Epidemiology, National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: N
authors.initials: N
authors.lastname: Miao
authors.affiliation: Division 2 of Epidemiology, National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Sun
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Liang
authors.affiliation: Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: F Q
authors.initials: FQ
authors.lastname: Cui
mesh_terms: D002648:Child; D002681:China / Q000453:epidemiology; D004334:Drug Administration Schedule; D005260:Female; D006301:Health Services Needs and Demand; D006509:Hepatitis B / Q000208:ethnology* / Q000276:immunology* / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D017589:Immunization Programs; D008297:Male; D015995:Prevalence; D012424:Rural Population; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D014505:Urban Population; D014611:Vaccination
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: Hepatitis B surface antigen; Hepatitis B vaccine; Timely birth dose