title: Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity.
abstract: Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. cyy412@126.com.
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. jonathan.moloney@stcatz.ox.ac.uk.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Moloney
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. kirsten.christensen@chem.ox.ac.uk.
authors.forename: Kirsten E
authors.initials: KE
authors.lastname: Christensen
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. mark.moloney@chem.ox.ac.uk.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney
keywords: annulation; antibacterial; heteroaromatic; polyheterocycle; tetramate