title: Unprecedented Access to β-Arylated Selenophenes through Palladium-Catalysed Direct Arylation.
abstract: Several reported methods allow access to α-arylated selenophenes, whereas the synthesis of β-arylated selenophenes remains very challenging. Here, the Pd-catalysed coupling of benzenesulfonyl chlorides with selenophenes affording regiospecific β-arylated selenophenes is reported. The reaction proceeds with easily accessible catalyst, base and substrates, and tolerates a variety of substituents both on the benzene and selenophene moieties. This transformation allows the programmed synthesis of polyarylated selenophenes with potential applications in pharmaceutical and materials chemistry, as the installation of aryl groups at the desired positions can be achieved.
authors.affiliation: Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS-, Université de Rennes 1, "Organométalliques: Matériaux et Catalyse", Campus de Beaulieu, 35042, Rennes, France.|Laboratoire de Chimie Organique Physique (UR 11ES74), Université de Sfax, Faculté des Sciences de Sfax, Route de la Soukra km 4, 3038, SFax, Tunisia.
authors.forename: Aymen
authors.initials: A
authors.lastname: Skhiri
authors.affiliation: Laboratoire de Chimie Organique Physique (UR 11ES74), Université de Sfax, Faculté des Sciences de Sfax, Route de la Soukra km 4, 3038, SFax, Tunisia.
authors.forename: Ridha Ben
authors.initials: RB
authors.lastname: Salem
authors.affiliation: Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS-, Université de Rennes 1, "Organométalliques: Matériaux et Catalyse", Campus de Beaulieu, 35042, Rennes, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Soulé
authors.affiliation: Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS-, Université de Rennes 1, "Organométalliques: Matériaux et Catalyse", Campus de Beaulieu, 35042, Rennes, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Doucet
keywords: C−H functionalization; benzenesulfonyl chlorides; homogeneous catalysis; palladium; selenophenes