title: Preoperative MRI of the breast and ipsilateral breast tumor recurrence: Long-term follow up.
abstract: BACKGROUND
  Local recurrence after breast conserving surgery is reported in 5-10% of cases. This study aims to determine if preoperative MRI is associated with reduced IBTR rates in the longer term and evaluate IBTR rates of a high risk (TN and Her-2 positive) subgroup in those receiving MRI or not.
  
  
  METHODS
  Between 1999 and 2005, patients with invasive breast cancer undergoing BCS and radiation were identified. Primary endpoint was IBTR rate.
  
  
  RESULTS
  The cohort consisted of 470 cases: 27% underwent MRI and 73% did not. Median follow-up was 97 months. Overall 10-year IBTR rate was 3.6%. There was no significant difference in IBTR rate at 10 years between those receiving MRI or not (1.6% vs. 4.2% (P = 0.37). The TN and Her-2 positive combined subgroup had a higher IBTR rate than all others (9.8% vs. 1.7%, P = 0.001). In the group without MRI, the IBTR rate of the high risk group was 11.8% compared to 1.8% in the remainder (P = 0.002).
  
  
  CONCLUSIONS
  With 10-year follow-up, there was no significant difference in IBTR rate whether preoperative MRI is performed versus not. The high risk population showed an increased IBTR rate, this was more marked in those who did not receive MRI.
authors.affiliation: Department of Surgery, University of Toronto, Toronto, ON, Canada.
authors.forename: Mai-Kim
authors.initials: MK
authors.lastname: Gervais
authors.affiliation: Division of General Surgery, University Health Network, Toronto, ON, Canada.
authors.forename: Ellen
authors.initials: E
authors.lastname: Maki
authors.affiliation: Division of General Surgery, University of Alberta, Edmonton, AB, Canada.
authors.forename: Dan E
authors.initials: DE
authors.lastname: Schiller
authors.affiliation: Department of Radiology, Division of Breast Imaging, University Health Network, Toronto, ON, Canada.
authors.forename: Pavel
authors.initials: P
authors.lastname: Crystal
authors.affiliation: Department of Surgery, University of Toronto, Toronto, ON, Canada.|Division of General Surgery, University Health Network, Toronto, ON, Canada.
authors.forename: David R
authors.initials: DR
authors.lastname: McCready
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*
keywords: Her-2 positive; breast cancer; breast conserving surgery; triple negative