title: Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy.
abstract: OBJECTIVE
  Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of pre-eclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women.
  
  
  METHODS
  This study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women (gestational age >20 weeks) were included in the study with distribution as Preeclampsia (PE=86), Eclampsia (E=74) and control (N=74). Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay (ELISA) technique. SPSS version 19 was used for statistical analysis. Student's t test was performed to evaluate the mean differences in patients and control.
  
  
  RESULTS
  Serum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control (P value<0.001).: Comparisons of mean value of visfatin with age group of 21-40 years, body mass index (BMI), primary parous and parity 2-4, gestational age of >36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control (p value<0.001).
  
  
  CONCLUSIONS
  Pregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women.
authors.affiliation: Dr. Asmat Shaheen, BDS, M.Phil. Assistant Professor of Biochemistry, Institute of Medical Sciences, Khyber Medical University (KMU), Kohat, Pakistan.
authors.forename: Asmat
authors.initials: A
authors.lastname: Shaheen
authors.affiliation: Dr. Rubina Nazli, MBBS, PhD. Professor of Biochemistry, Institute of Basic Medical Sciences (IBMS), Khyber Medical University, Peshawar, Pakistan.
authors.forename: Rubina
authors.initials: R
authors.lastname: Nazli
authors.affiliation: Dr. Sadia Fatima, MBBS, PhD. Assistant Professor of Biochemistry, Institute of Basic Medical Sciences (IBMS), Khyber Medical University, Peshawar, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Fatima
authors.affiliation: Dr. Roshan Ali, PhD. Assistant Professor of Biochemistry, Institute of Basic Medical Sciences (IBMS), Khyber Medical University, Peshawar, Pakistan.
authors.forename: Roshan
authors.initials: R
authors.lastname: Ali
authors.affiliation: Ihsanuullah Khan, M.Phil, Institute of Basic Medical Sciences (IBMS), Khyber Medical University, Peshawar, Pakistan.
authors.forename: Ihsanullah
authors.initials: I
authors.lastname: Khan
authors.affiliation: Dr. Salim Khattak, MBBS, FCPS. Department of Surgery, Institute of Medical Sciences, Khyber Medical University (KMU), Kohat, Pakistan.
authors.forename: Salim
authors.initials: S
authors.lastname: Khattak
keywords: Eclampsia; Hypertension; Normotensive pregnant women; Pre-eclampsia; Pregnancy; Visfatin