title: Small molecules remain on target for c-Myc.
abstract: Targeting the transcription factor c-Myc via one of its coactivator proteins is a promising strategy for cancer therapy.
authors.affiliation: CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, China.
authors.forename: Linchong
authors.initials: L
authors.lastname: Sun
authors.affiliation: CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Gao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001381:Azepines / Q000008:administration & dosage*; D018797:Cell Cycle Proteins; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D006801:Humans; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D015203:Reproducibility of Results; D014157:Transcription Factors / Q000235:genetics*; D014230:Triazoles / Q000008:administration & dosage*; D023041:Xenograft Model Antitumor Assays; D000092468:Bromodomain Containing Proteins
chemical_list: D001381:Azepines; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; D014230:Triazoles; C561695:(+)-JQ1 compound; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C489427:MYC protein, human
keywords: Reproducibility Project: Cancer Biology; bromodomain inhibitor; cancer biology; human; metascience; mouse; myeloma; replication; reproducibility