title: Electrodiagnosis of reversible conduction failure in Guillain-Barré syndrome.
abstract: BACKGROUND
  In this study we propose electrodiagnostic criteria for early reversible conduction failure (ERCF) in axonal Guillain-Barré syndrome (GBS) and apply them to a cohort of GBS patients.
  
  
  METHODS
  Serial nerve conduction studies (NCS) were retrospectively analyzed in 82 GBS patients from 3 centers. The criteria for the presence of ERCF in a nerve were: (i) a 50% increase in amplitude of distal compound muscle action potentials or sensory nerve action potentials; or (ii) resolution of proximal motor conduction block with an accompanying decrease in distal latencies or compound muscle action potential duration or increase in conduction velocities.
  
  
  RESULTS
  Of 82 patients from 3 centers, 37 (45%) had ERCF, 21 (26%) had a contrasting evolution pattern, and 8 (10%) had both. Sixteen patients did not show an amplitude increase of at least 50%.
  
  
  CONCLUSIONS
  Our proposed criteria identified a group of patients with a characteristic evolution of NCS abnormality that is consistent with ERCF. Muscle Nerve 56: 919-924, 2017.
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.|Division of Neurology, University Medicine Cluster, National University Hospital, NUHS Tower Block, Level 10, 119228, Singapore.
authors.forename: Yee-Cheun
authors.initials: YC
authors.lastname: Chan
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Aubrey M
authors.initials: AM
authors.lastname: Punzalan-Sotelo
authors.affiliation: Division of Neurology, University Medicine Cluster, National University Hospital, NUHS Tower Block, Level 10, 119228, Singapore.
authors.forename: Therimadasamy A
authors.initials: TA
authors.lastname: Kannan
authors.affiliation: Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Nortina
authors.initials: N
authors.lastname: Shahrizaila
authors.affiliation: National Neuroscience Institute, Singapore.
authors.forename: Thirugnanam
authors.initials: T
authors.lastname: Umapathi
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Eunice J H
authors.initials: EJH
authors.lastname: Goh
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fukami
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Einar
authors.identifier: http://orcid.org/0000-0003-3402-7503
authors.initials: E
authors.lastname: Wilder-Smith
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D001323:Autoantibodies / Q000097:blood; D004568:Electrodiagnosis; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007391:International Cooperation; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology*; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D005732:Gangliosides
keywords: Guillain-Barré syndrome; acute inflammatory demyelinating polyneuropathy; acute motor axonal neuropathy; conduction block; electrodiagnostic criteria; reversible conduction failure