title: Chiral bidentate [N,S]-ferrocene ligands based on a thiazoline framework. Synthesis and use in palladium-catalyzed asymmetric allylic alkylation.
abstract: An efficient method to obtain chiral 1,2-disubstituted ferrocenyl ligands has been developed. The introduction of planar chirality was accomplished by using 2-thiazoline as an ortho-directing lithiation group, and moreover, these kinds of ligands possess a central chirality from the amino alcohol used in their synthesis. The X-ray analysis and DFT calculations confirmed the diastereoselectivity of ortho-lithiation and the configuration of the planar chirality. The ability of these new bidentate [N,S]-ferrocene ligands to act in Pd-catalyzed asymmetric allylic alkylation has also been demonstrated and compared with their oxazoline counterparts.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, CdMx, Mexico. jglcvdw@unam.mx.
authors.forename: E P
authors.initials: EP
authors.lastname: Sánchez-Rodríguez
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, CdMx, Mexico. jglcvdw@unam.mx.
authors.forename: F
authors.initials: F
authors.lastname: Hochberger-Roa
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, CdMx, Mexico. jglcvdw@unam.mx.
authors.forename: R
authors.initials: R
authors.lastname: Corona-Sánchez
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, CdMx, Mexico. jglcvdw@unam.mx.
authors.forename: J E
authors.initials: JE
authors.lastname: Barquera-Lozada
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, CdMx, Mexico. jglcvdw@unam.mx.
authors.forename: R A
authors.initials: RA
authors.lastname: Toscano
authors.affiliation: CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, 31077 Toulouse, France. gouygou@lcc-toulouse.fr and Université de Toulouse, UPS, INPT, 31077 Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Urrutigoïty
authors.affiliation: CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, 31077 Toulouse, France. gouygou@lcc-toulouse.fr and Université de Toulouse, UPS, INPT, 31077 Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Gouygou
authors.affiliation: Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, CdMx, Mexico.
authors.forename: M C
authors.initials: MC
authors.lastname: Ortega-Alfaro
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, CdMx, Mexico. jglcvdw@unam.mx.
authors.forename: J G
authors.identifier: http://orcid.org/0000-0002-4508-117X
authors.initials: JG
authors.lastname: López-Cortés