title: ASSESSMENT OF RETINAL BLOOD FLOW IN DIABETIC RETINOPATHY USING DOPPLER FOURIER-DOMAIN OPTICAL COHERENCE TOMOGRAPHY.
abstract: OBJECTIVE
  To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT).
  
  
  METHODS
  Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the optic nerve head were obtained. Doppler OCT scans and accessory imaging data were imported into Doppler OCT of Retinal Circulation grading software to calculate TRBF and vascular parameters (e.g., venous and arterial cross-sectional area). Measurements were compared between cases and controls using independent t-tests.
  
  
  RESULTS
  Mean TRBF was 44.98 ± 9.80 (range: 30.18-64.58) µL/minute for normal eyes, 35.80 ± 10.48 (range: 20.69-49.56) µL/minute for eyes with severe NPDR, and 34.79 ± 10.61 (range: 16.77-48.9) µL/minute for eyes with PDR. Mean TRBF was significantly lower in eyes with severe NPDR (P = 0.01) and PDR (P = 0.003) than in normal eyes.
  
  
  CONCLUSIONS
  Total retinal blood flow was significantly lower in eyes with severe NPDR and PDR compared with normal eyes. Retinal blood flow determined by Doppler OCT may be a useful parameter for evaluating patients with DR.
authors.affiliation: *Doppler OCT Reading Center, Doheny Eye Institute, Los Angeles, California; †Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; ‡Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma; §Department of Ophthalmology, Northwestern University, Chicago, Illinois; and ¶Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Srinivas
authors.forename: Ou
authors.initials: O
authors.lastname: Tan
authors.forename: Muneeswar G
authors.initials: MG
authors.lastname: Nittala
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Wu
authors.forename: Amani A
authors.initials: AA
authors.lastname: Fawzi
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.forename: SriniVas R
authors.initials: SR
authors.lastname: Sadda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology*; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology*; D012160:Retina / Q000473:pathology / Q000503:physiopathology*; D012171:Retinal Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*