title: The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds.
abstract: Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing processes of pharmaceutical compounds, in accordance with recent regulatory, economical and quality guidances. The chemical and technical knowledge gained during these studies is considerable; nevertheless, connecting several individual chemical transformations and the attached analytics and purification holds hidden traps. In this review, we summarize innovative solutions for these challenges, in order to benefit chemists aiming to exploit flow chemistry systems for the synthesis of biologically active molecules.
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Bana
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary.
authors.forename: Róbert
authors.initials: R
authors.lastname: Örkényi
authors.affiliation: Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary.
authors.forename: Klára
authors.initials: K
authors.lastname: Lövei
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Lakó
authors.affiliation: Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary.
authors.forename: György István
authors.initials: GI
authors.lastname: Túrós
authors.affiliation: Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Éles
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary; MTA-BME Organic Chemical Technology Research Group, Budafoki út 8, H-1111 Budapest, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Faigl
authors.affiliation: Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary. Electronic address: i.greiner@richter.hu.
authors.forename: István
authors.initials: I
authors.lastname: Greiner
mesh_terms: D005740:Gases / Q000737:chemistry; D015386:Hazardous Substances / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D005740:Gases; D015386:Hazardous Substances; D004364:Pharmaceutical Preparations; D012997:Solvents
keywords: Active pharmaceutical ingredient; Continuous flow processing; Continuous purification; In-line analytics; Multistep flow synthesis; Telescoping