title: Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin.
abstract: The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Xu
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.|Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, Guangzhou, China.
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Yang
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Lilan
authors.initials: L
authors.lastname: Wu
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Qi
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Yunshan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Yucui
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Lipeng
authors.initials: L
authors.lastname: Tang
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.|Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, Guangzhou, China.|Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, China.
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
mesh_terms: D002152:Calorimetry, Differential Scanning; D002479:Inclusion Bodies / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; D047392:beta-Cyclodextrins; C052983:patchouli alcohol