title: Long-Latency Somatosensory Evoked Potentials of the Subthalamic Nucleus in Patients with Parkinson's Disease.
abstract: Somatosensory evoked potentials (SSEPs) are a viable way to measure processing of somatosensory information. SSEPs have been described at the scalp and the cortical level by electroencephalographic, magnetoencephalographic and intracranial cortical recordings focusing on short-latency (SL; latency<40 ms) and long-latency (LL; latency>40 ms) SSEPs as well as by deep brain stimulation (DBS) electrode studies targeting SL-SSEPs. Unfortunately, LL-SSEPs have not been addressed at the subcortical level aside from the fact that studies targeting the characteristics and generators of SSEPs have been neglected for the last ten years. To cope with these issues, we investigated LL-SSEPs of the subthalamic nucleus (STN) in twelve patients with Parkinson's disease (PD) that underwent deep brain stimulation (DBS) treatment. In a postoperative setting, LL-SSEPs were elicited by median nerve stimulation (MNS) to the patient's wrists. Ipsilateral or contralateral MNS was applied with a 3 s inter-stimulus interval. Here, we report about four distinctive LL-SSEPs ("LL-complex" consisting of P80, N100, P140 and N200 component), which were recorded by using monopolar/bipolar reference and ipsi/contralateral MNS. Phase reversal and/or maximum amplitude provided support for the generation of such LL-SSEPs within the STN, which also underscores a role of this subcortical structure in sensory processing.
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.|Department of Neurology, University Clinic, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Carlos
authors.initials: C
authors.lastname: Trenado
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.|Department of Neurology, University Clinic, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Saskia
authors.initials: S
authors.lastname: Elben
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Friggemann
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Gruhn
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.|Department of Neurology, University Clinic, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Stefan Jun
authors.initials: SJ
authors.lastname: Groiss
authors.affiliation: Department of Functional and Stereotactic Neurosurgery, University Clinic, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Vesper
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.|Department of Neurology, University Clinic, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.|Department of Neurology, University Clinic, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Wojtecki
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D013997:Time Factors