title: A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical.
abstract: Different solid state forms of the research chemical fasoracetam, which counters the effects of Alzheimer's disease, have been subjected to a thermal and structural analysis. Single crystals were obtained from solution evaporation and from the melt. Single-crystal X-ray analyses of the crystals show the existence of 2 hydrated and 1 non-hydrated crystalline form of fasoracetam. Under ambient conditions, the hydrate form I is found to be the most stable form, showing a melting point of 57C. This low melting point, combined with possible water losses could cause problems when formulating the hydrated form and impact the storage conditions of the compound.
authors.affiliation: Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
authors.forename: Bram
authors.initials: B
authors.lastname: Harmsen
authors.affiliation: Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
authors.forename: Koen
authors.initials: K
authors.lastname: Robeyns
authors.affiliation: Namur Institute for Life Sciences (Narilis), University of Namur, Namur, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Wouters
authors.affiliation: Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Louvain-la-Neuve, Belgium. Electronic address: Tom.Leyssens@uclouvain.be.
authors.forename: Tom
authors.initials: T
authors.lastname: Leyssens
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D003460:Crystallization; D018697:Nootropic Agents / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D010880:Piperidines / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D014961:X-Ray Diffraction / Q000379:methods*
chemical_list: C106626:5-oxo-D-prolinepiperidinamide monohydrate; D018697:Nootropic Agents; D004364:Pharmaceutical Preparations; D010880:Piperidines; D011392:Proline
keywords: Alzheimer’s disease; calorimetry (DSC); crystal structure; hydrate; polymorphism; solvent evaporation; thermogravimetric analysis