title: The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging.
abstract: The hematopoietic system has the remarkable ability to provide a lifelong supply of mature cells that make up the entire blood and immune system. However, similar to other adult stem cell niches, the hematopoietic system is vulnerable to the detrimental effects of aging. This is a substantial health concern as the trend for population aging continues to increase. Identifying mechanisms that underlie hematopoietic aging is vital for understanding hematopoietic-related diseases. In this review, we first discuss the cellular hierarchy of the hematopoietic system and the components that make up the surrounding hematopoietic niche. We then provide an overview of the major phenotypes associated with hematopoietic aging and discuss recent research investigating cell-intrinsic and cell-extrinsic mechanisms of hematopoietic stem cell (HSCs) aging. We end by discussing the exciting new concept of possibly reversing the HSC aging process along with outstanding questions that remain to be answered.
authors.affiliation: Endocrine Metabolism Division, University of Rochester School of Medicine and Dentistry, Rochester NY.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Latchney
authors.affiliation: Endocrine Metabolism Division, University of Rochester School of Medicine and Dentistry, Rochester NY; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester NY. Electronic address: laura_calvi@urmc.rochester.edu.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Calvi
mesh_terms: D002454:Cell Differentiation; D016922:Cellular Senescence / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D010641:Phenotype
keywords: Aging; Cell-extrinsic; Cell-intrinsic; Hematopoietic stem cells; Microenvironment