title: The effect of dexpanthenol on experimentally induced ovarian ischaemia/reperfusion injury: a biochemical and histopathological evaluation.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of two different doses of dexpanthenol (Dxp) onexperimentally induced ovarian ischaemia/reperfusion (I/R) injury ina rat model.
  
  
  METHODS
  Forty female rats were randomly divided into fivegroups: Group 1: sham operation; Group 2: 3-h ischaemia; Groups 3: 3-h ischaemia, 3-h reperfusion (I/R); Group 4: I/R + 300 mg/kg Dxp intraperitoneally (i.p) Group 5: I /R + 500 mg/kg Dxpi.p. Total anti-oxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tissue malondialdehyde (MDA) and activities of glutathione peroxidase and catalase were calculated. Ovarian tissue damage was assessed using a histopathological scoring system.
  
  
  RESULTS
  The TOS and OSI values were significantly lower in Group 5, as compared to Groups 2 and 3 (p < 0.05). The MDA levels in Group 1 and Group 5 were significantly lower than those in Group 3 (p < 0.05). CAT and GSH-Px activity was higher in Group 5 than in Group 2 and Group 3 (p = 0.00). Tissue damage scores were elevated in all the groups compared with sham group, but the treatment with the different doses of Dxp before reperfusion ameliorated the tissue damage scores.
  
  
  CONCLUSIONS
  The results showed that Dxp reduced ovarian I/R injury.
authors.affiliation: Department of Obstetrics and Gynaecology, Mustafa Kemal University Faculty of Medicine, Antakya, Hatay, Turkey. oyakarapinar@hotmail.com.|, Ürgenpaşa Mahallesi, 41. Sokak, Esen Apartmani, Daire 7, Antakya, Hatay, Turkey. oyakarapinar@hotmail.com.
authors.forename: Oya
authors.initials: O
authors.lastname: Soylu Karapinar
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Pinar
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey.
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Özcan
authors.affiliation: Department of Pathology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Atik Doğan
authors.affiliation: Department of Medical Microbiology, Çukurova University Faculty of Medicine, Adana, Turkey.
authors.forename: Suphi
authors.initials: S
authors.lastname: Bayraktar
authors.affiliation: Department of Obstetric and Gynaecology, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hanifi
authors.initials: H
authors.lastname: Şahin
authors.affiliation: Department of Obstetrics and Gynaecology, Mustafa Kemal University Faculty of Medicine, Antakya, Hatay, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Dolapçioğlu
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D010205:Pantothenic Acid; C007288:dexpanthenol; D002374:Catalase; D005979:Glutathione Peroxidase
keywords: Dexpanthenol; Ischaemia/reperfusion; Ovarian torsion; Oxidative stress