title: Clinicopathological features, diagnosis, and treatment of IgA nephropathy with minimal change disease related to exposure to mercury-containing cosmetics: a case report .
abstract: OBJECTIVE
  Membranous nephropathy and minimal change disease (MCD) have been involved in mercury-induced nephrotic syndrome. IgA nephropathy is not known to be a common pathological type. In the present article, we report a case of IgA nephropathy with MCD following exposure to mercury-containing skin lightening cream.
  
  
  METHODS
  The patient was a 39-year-old woman who presented with nephrotic syndrome. She had a 6-month history of using as many as 8 kinds of skin-lightening creams, and urinary mercury excretion was high. Renal biopsy revealed IgA nephropathy with MCD. The use of cosmetics was stopped and chelation therapy was given. After 4 courses (1 month) of chelation therapy, there was a complete remission of proteinuria and hematuria, and urine tests remained normal during the 5-year follow-up period.
  
  
  CONCLUSIONS
  The unique clinical and pathological features of IgA nephropathy with MCD had raised the controversial question of whether MCD and IgA deposition are separate entities or a common pathophysiology. Repeated renal biopsy and similar cases were helpful and should be carried out as far as possible. .
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Niu
authors.forename: Shen-Heng
authors.initials: SH
authors.lastname: Li
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Li
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Chen
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Liu
authors.forename: Pei-Lin
authors.initials: PL
authors.lastname: Li
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Long
mesh_terms: D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use; D005260:Female; D005922:Glomerulonephritis, IGA / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D008630:Mercury Poisoning / Q000150:complications* / Q000188:drug therapy; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D009404:Nephrotic Syndrome / Q000209:etiology / Q000628:therapy; D011507:Proteinuria / Q000209:etiology; D012074:Remission Induction; D062327:Skin Lightening Preparations / Q000737:chemistry / Q000506:poisoning*; D014494:Unithiol / Q000627:therapeutic use
chemical_list: D002614:Chelating Agents; D062327:Skin Lightening Preparations; D014494:Unithiol