title: Open-Label Study Evaluating the Anti-Aging Effects of a 3-Product, 2-Step Retinol-Rejuvenation System Following 3 Months of Treatment in Subjects With Photodamage.
abstract: BACKGROUND
  Photodamage to the skin occurs with exposure to sunlight (UVA or UVB) either intentionally or unintentionally, and can present in a variety of ways. It typically occurs on areas of chronic UV exposure, including the face, ears, and neck.
  
  
  METHODS
  We evaluated the effects of a 3-product, 2-step retinol-rejuvenation system containing an exfoliating cleanser, a 0.5% retinol emollient cream, and SPF 30 moisturizing sunscreen used daily for 3 months on the appearance of mild-to-moderate facial photodamage in female subjects.
  
  
  RESULTS
  Significant improvements in facial appearance could be observed as early as 2 weeks, with continued improvement over the duration of the study. There were no adverse events reported that were related to study product and reports of cutaneous tolerability issues were rare.
  
  
  CONCLUSIONS
  A 3-product, 2-step retinol-rejuvenation system provides significant improvements in signs of photodamage and overall skin appearance, and is well-tolerated. <em>J Drugs Dermatol. 2017;16(1):23-28.</em>.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Bruce
authors.forename: Sylvia
authors.initials: S
authors.lastname: Barkovic
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012060:Rejuvenation / Q000502:physiology*; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*; D017592:Skin Care / Q000379:methods*; D013473:Sunscreening Agents / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014801:Vitamin A / Q000008:administration & dosage*
chemical_list: D013473:Sunscreening Agents; D014801:Vitamin A