title: Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis.
abstract: The present study was designed to assess the dynamic patterns of pro-inflammatory cytokines, including IFN-γ, TNF-α, IL-4, IL-6, acute phase protein (α1-acid-glycoprotein, AGP), and an inflammation associated factor (adenosine deaminase; ADA) following experimental caprine coccidiosis. Ten kids aging from 2 to 4 months were infected orally with 5×104sporulated oocysts and 10 animals served as controls. Blood samples were collected in both groups before infection and at days 3, 7, 14, 21, 28, and 35 post-infection (PI), and the levels of above-mentioned factors were measured. IFN-γ, TNF-α, IL-4, IL-6, AGP, and ADA activities were significantly higher in infected animals from day 7 PI (P<0.05). In conclusion, the circulatory levels of most systemic inflammatory markers, including pro-inflammatory cytokines (IFN-γ, TNF-α, IL-4, IL-6), AGP, and ADA increased significantly starting from day 3 to day 7 PI in caprine coccidiosis.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Shiraz University, 1731, Shiraz 71345, Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Tadayon
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Shiraz University, 1731, Shiraz 71345, Iran.
authors.forename: Seyed Mostafa
authors.initials: SM
authors.lastname: Razavi
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, 1731, Shiraz 71345, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Nazifi
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D003048:Coccidiosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D015511:Goat Diseases / Q000276:immunology / Q000473:pathology*; D006041:Goats; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000097:blood*; D013997:Time Factors
chemical_list: D007155:Immunologic Factors
keywords: Eimeria arloingi; Eimeria caprina; Eimeria ninakohlyakimovae; caprine coccidiosis; inflammatory factor; systemic innate immunity