title: PERIPAPILLARY RETINAL NERVE FIBER THICKNESS CHANGES AFTER VITRECTOMY FOR EPIRETINAL MEMBRANE IN EYES WITH AND WITHOUT VITREOUS DETACHMENT.
abstract: OBJECTIVE
  To compare the changes in postoperative peripapillary retinal nerve fiber layer (p-RNFL) thickness after vitrectomy for epiretinal membrane in eyes with preexisting posterior vitreous detachment (PVD) and eyes with surgically induced PVD.
  
  
  METHODS
  This study included consecutive patients who underwent 25-gauge vitrectomy for epiretinal membrane. Eyes were divided, according to intraoperative PVD status, into a preexisting PVD group and surgically induced PVD group. Best-corrected visual acuity, p-RNFL thickness, and central retinal thickness were performed before and at 1, 3, and 6 months after surgery.
  
  
  RESULTS
  One hundred and twenty eyes of 120 patients were enrolled: 64 eyes in the preexisting PVD group and 56 eyes in the surgically induced PVD group. In the preexisting PVD group at 6 months, the mean global p-RNFL thickness did not change, whereas it was reduced in the temporal sector (P = 0.034). In the surgically induced PVD group at 6 months, significant decreases were observed in global p-RNFL thickness (P = 0.027), temporal (P = 0.021), temporal inferior (P = 0.030), and nasal inferior sectors (P = 0.010). At 6 months, the two groups differed significantly in temporal (P < 0.001) and temporal inferior sectors (P = 0.004). The preoperative mean best-corrected visual acuity improved significantly at 6 months in both groups.
  
  
  CONCLUSIONS
  Postoperative p-RNFL thickness after vitrectomy for epiretinal membrane tended to decrease in the temporal sector in all eyes and in the temporal inferior and nasal inferior sectors in eyes with surgically induced PVD.
authors.affiliation: Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Mariotti
authors.affiliation: Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Nicolai
authors.affiliation: Department of Ophthalmology, University of Catania, Catania, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Longo
authors.affiliation: Eye Clinic, University Hospital "Ospedali Riuniti," Ancona, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Viti
authors.affiliation: Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Bambini
authors.affiliation: Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Saitta
authors.affiliation: Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Pirani
authors.affiliation: Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Orsini
authors.affiliation: Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Baruffa
authors.affiliation: Department of Ophthalmology, University of Catania, Catania, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Reibaldi
mesh_terms: D000368:Aged; D019773:Epiretinal Membrane / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk; D011184:Postoperative Period; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D014821:Vitrectomy / Q000295:instrumentation*; D020255:Vitreous Detachment / Q000150:complications / Q000175:diagnosis / Q000601:surgery*