title: Folate-Engineered Microvesicles for Enhanced Target and Synergistic Therapy toward Breast Cancer.
abstract: As an ideal nanovector candidate, microvesicles (MVs) have been gradually utilized for packaging kinds of functional molecules for effective tumor diagnosis and therapy; however, the deficiency of their tumor targeting influenced their therapy efficacy. Through a facile phospholipid substitution strategy, MVs-based drug delivery system (DDS) was apparently endowed with high tumor targeting toward breast cancer thanks to the modified folate onto the membrane of MVs, simultaneously possessing a synergistic antitumor effect, and in vivo tumor imaging attributed to the SA-QDs labeling. Tumor killing effect could be improved up to 15 percentages with the help of the improved tumor targeting ability.
authors.affiliation: College of Chemistry and Molecular Sciences, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Wuhan University , Wuhan 430072, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhu
authors.affiliation: College of Chemistry and Molecular Sciences, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Wuhan University , Wuhan 430072, China.
authors.forename: Di
authors.initials: D
authors.lastname: Dong
authors.affiliation: School and Hospital of Stomatology, Key Laboratory of Oral Biomedicine (Ministry of Education) and Department of Oral and Maxillofacial Surgery, Wuhan University , Wuhan 430079, China.
authors.forename: Zi-Li
authors.initials: ZL
authors.lastname: Yu
authors.affiliation: School and Hospital of Stomatology, Key Laboratory of Oral Biomedicine (Ministry of Education) and Department of Oral and Maxillofacial Surgery, Wuhan University , Wuhan 430079, China.
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Molecular Sciences, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Wuhan University , Wuhan 430072, China.
authors.forename: Dai-Wen
authors.initials: DW
authors.lastname: Pang
authors.affiliation: College of Chemistry and Molecular Sciences, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Wuhan University , Wuhan 430072, China.
authors.forename: Zhi-Ling
authors.identifier: http://orcid.org/0000-0001-7807-2264
authors.initials: ZL
authors.lastname: Zhang
mesh_terms: D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D055252:Cell-Derived Microparticles; D016503:Drug Delivery Systems; D005492:Folic Acid; D006801:Humans
chemical_list: D005492:Folic Acid
keywords: in vivo imaging; microvesicles; phospholipid substitution; synergistic therapy; tumor targeting