title: Beneficial Effects of Ozone Therapy on Oxidative Stress, Cardiac Functions and Clinical Findings in Patients with Heart Failure Reduced Ejection Fraction.
abstract: The aim of study was to determine the effects of ozone therapy on the oxidative stress, cardiac functions and clinical findings in patients with heart failure reduced ejection fraction (HFrEF). A total of 40 patients with New York Heart Association 2 and 3 HF with left ventricular ejection fraction (LVEF) <35%, and 40 subjects without HF as control group were included in the study. Patients with HFrEF were given additional ozone therapy of major and minor administrations along with conventional HF treatment for 5 weeks. Before and after ozone therapy, left ventricular end-systolic and end-diastolic volumes (LVESV, LVEDV) and the 6 minute walk distance (6MWD) and blood levels of the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GSHPx), malondialdehyde (MDA), nitric oxide (NO) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured. Ozone therapy significantly reduced the serum levels of NO and MDA (p < 0.001, respectively) and significantly increased the levels of SOD, CAT, GSH and GSHPx (p < 0.001, respectively). LVEDV and LVESV were found to be significantly reduced; however, LVEF was not found to be significantly increased (p = 0.567). As the biochemical improvement marker of HF, NT-proBNP was significantly reduced (p < 0.001). The clinical HF improvement marker of 6 minute walk distance was also modestly increased (p < 0.001). Ozone therapy might be beneficial in terms of activating antioxidant system and merit further therapeutic potential to conventional HF treatment in patients with HFrEF.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Erzincan University, 24500, Erzincan, Turkey. mutlubuyuklu@gmail.com.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Buyuklu
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, 25000, Erzurum, Turkey.
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Kandemir
authors.affiliation: Department of Family Physician, Faculty of Medicine, Karadeniz Technical University, 61000, Trabzon, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Set
authors.affiliation: Department of Cardiology, Faculty of Medicine, Erzincan University, 24500, Erzincan, Turkey.
authors.forename: Eftal Murat
authors.initials: EM
authors.lastname: Bakırcı
authors.affiliation: Department of Cardiology, Faculty of Medicine, Erzincan University, 24500, Erzincan, Turkey.
authors.forename: Husnu
authors.initials: H
authors.lastname: Degirmenci
authors.affiliation: Department of Cardiology, Faculty of Medicine, Erzincan University, 24500, Erzincan, Turkey.
authors.forename: Hikmet
authors.initials: H
authors.lastname: Hamur
authors.affiliation: Department of Cardiology, Faculty of Medicine, Erzincan University, 24500, Erzincan, Turkey.
authors.forename: Ergun
authors.initials: E
authors.lastname: Topal
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, 25000, Erzurum, Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Kucukler
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, 42000, Konya, Turkey.
authors.forename: Kultigin
authors.initials: K
authors.lastname: Turkmen
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010126:Ozone / Q000008:administration & dosage*; D013318:Stroke Volume / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D010126:Ozone
keywords: Antioxidant system; Heart failure; Oxidative stress; Ozone therapy