title: White Matter Abnormalities in Two Different Subtypes of Amnestic Mild Cognitive Impairment.
abstract: White matter (WM) degeneration has been found during the course of cognitive decline in both Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), however, it is unclear whether there are different WM microstructural abnormalities between two subtypes of aMCI, including single domain aMCI (aMCI-s) and multiple domain aMCI (aMCI-m). Thirty-two patients of aMCI single-domain (aMCI-s), twenty-three patients of aMCI multiple-domain (aMCI-m) and twenty-three healthy normal controls (NC) participated in this study. Neuropsychological measures and diffusion tensor imaging (DTI) data were acquired from each subject and tract-based spatial statistics (TBSS) was implemented. It was found that both aMCI groups showed significantly reduced fractional anisotropy (FA) in the right superior longitudinal fasciculus (SLF) than NC. It was also identified that, as compared to aMCI-m, aMCI-s showed significantly decreased FA in the left SLF, left uncinate fasciculus (UF) and left inferior longitudinal fasciculus (ILF), while significantly increased FA in the left anterior thalamic radiation (ATR). The correlation analysis showed that FA values in the regions with group difference were significantly correlated with cognitive functions as measured by Boston naming test and trail making test. These results suggested that the variations of aMCI may be differentiated by FA indexes and DTI may help to understand why specific signs and symptoms occur in patients.
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, China.|Beijing Key Lab of MRI and Brain Informatics, Beijing, China.
authors.forename: Peipeng
authors.initials: P
authors.lastname: Liang
authors.affiliation: Department of Pharmacology, Xuan Wu Hospital, Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Shu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Tengda
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Fangyu
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhilian
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, China.|Beijing Key Lab of MRI and Brain Informatics, Beijing, China.
authors.forename: Kuncheng
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.|Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
mesh_terms: D000368:Aged; D000647:Amnesia / Q000150:complications* / Q000523:psychology; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*