title: Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease.
abstract: We recently compared results of fecal microbiota transplantation (FMT) in patients with refractory, recurrent Clostridium difficile infection (rCDI), with and without underlying inflammatory bowel disease (IBD). Here we extend this cohort and analyze outcomes in greater detail by subtype of IBD. We find that FMT is generally effective in breaking the cycle of CDI recurrence, but its effects on overall IBD progression are much less predictable. We discuss several challenges intrinsic to this complex clinical situation and outline the next steps that can address these challenges going forward.
authors.affiliation: a Department of Medicine , University of Minnesota , Minneapolis , Minnesota , USA.
authors.forename: Krista M
authors.initials: KM
authors.lastname: Newman
authors.affiliation: a Department of Medicine , University of Minnesota , Minneapolis , Minnesota , USA.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Rank
authors.affiliation: a Department of Medicine , University of Minnesota , Minneapolis , Minnesota , USA.
authors.forename: Byron P
authors.identifier: 0000-0001-5081-3761
authors.initials: BP
authors.lastname: Vaughn
authors.affiliation: a Department of Medicine , University of Minnesota , Minneapolis , Minnesota , USA.|b Center for Immunology and BioTechnology Institute , University of Minnesota , Twin Cities Campus, Minneapolis , Minnesota , USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Khoruts
mesh_terms: D000328:Adult; D003015:Clostridium Infections / Q000628:therapy*; D015331:Cohort Studies; D000069467:Fecal Microbiota Transplantation; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000628:therapy*; D007422:Intestines / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D055815:Young Adult
keywords: Crohn's disease; clostridium difficile; fecal microbiota transplantation; inflammatory bowel disease; ulcerative colitis