title: Could post-weaning dietary chia seed mitigate the development of dyslipidemia, liver steatosis and altered glucose homeostasis in offspring exposed to a sucrose-rich diet from utero to adulthood?
abstract: The present work analyzes the effects of dietary chia seeds during postnatal life in offspring exposed to a sucrose-rich diet (SRD) from utero to adulthood. At weaning, chia seed (rich in α-linolenic acid) replaced corn oil (rich in linoleic acid) in the SRD. At 150 days of offspring life, anthropometrical parameters, blood pressure, plasma metabolites, hepatic lipid metabolism and glucose homeostasis were analyzed. Results showed that chia was able to prevent the development of hypertension, liver steatosis, hypertriglyceridemia and hypercholesterolemia. Normal triacylglycerol secretion and triacylglycerol clearance were accompanied by an improvement of de novo hepatic lipogenic and carnitine-palmitoyl transferase-1 enzymatic activities, associated with an accretion of n-3 polyunsaturated fatty acids in the total composition of liver homogenate. Glucose homeostasis and plasma free fatty acid levels were improved while visceral adiposity was slightly decreased. These results confirm that the incorporation of chia seed in the diet in postnatal life may provide a viable therapeutic option for preventing/mitigating adverse outcomes induced by an SRD from utero to adulthood.
authors.affiliation: Departamento de Ciencias Biológicas, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, El Pozo, CC 242, 3000 Santa Fe, Argentina.
authors.forename: M A
authors.initials: MA
authors.lastname: Fortino
authors.affiliation: Departamento de Ciencias Biológicas, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, El Pozo, CC 242, 3000 Santa Fe, Argentina.
authors.forename: M E
authors.initials: ME
authors.lastname: Oliva
authors.affiliation: Departamento de Ciencias Biológicas, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, El Pozo, CC 242, 3000 Santa Fe, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Rodriguez
authors.affiliation: Departamento de Ciencias Biológicas, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, El Pozo, CC 242, 3000 Santa Fe, Argentina.
authors.forename: Y B
authors.initials: YB
authors.lastname: Lombardo
authors.affiliation: Departamento de Ciencias Biológicas, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, El Pozo, CC 242, 3000 Santa Fe, Argentina. Electronic address: achicco@fbcb.unl.edu.ar.
authors.forename: A
authors.initials: A
authors.lastname: Chicco
mesh_terms: D000818:Animals; D019422:Dietary Sucrose / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology; D050171:Dyslipidemias / Q000517:prevention & control*; D002523:Edible Grain / Q000737:chemistry; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000517:prevention & control*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D027544:Salvia / Q000737:chemistry*; D014886:Weaning; D017962:alpha-Linolenic Acid / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D019422:Dietary Sucrose; D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D017962:alpha-Linolenic Acid; D005947:Glucose
keywords: Blood pressure; Chia-seed; Dyslipidemia; Glucose homeostasis; Liver steatosis; α-linolenic acid (ALA)