title: Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients.
abstract: OBJECTIVE
  Flavin-containing monooxygenase (FMO) variants were potentially involved in tacrolimus metabolism in kidney transplantion. The influences of FMO3 genotypes on tacrolimus elimination in Chinese liver transplant patients remained unclear.
  
  
  METHODS
  FMO3 SNPs and CYP3A5 rs776746 were analyzed in 110 Chinese patients.
  
  
  RESULTS
  Donor FMO3 rs1800822 allele T and rs909530 allele T were associated with fast tacrolimus elimination. Combination of polymorphisms of donor FMO3 rs1800822 and rs909530 genotype impacted on tacrolimus elimination (p = 0.0221). The number of donor rs1800822 allele T and rs909530 allele T was confirmed to be an independent predictor of the tacrolimus concentration-to-dose ratios for weeks 2, 3 and 4 in the multivariate analysis.
  
  
  CONCLUSIONS
  Donor's FMO3 polymorphisms might affect tacrolimus elimination.
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, Shandong Qianfoshan Hospital, Shandong University, Jinan 250014, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ren
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, Shandong Qianfoshan Hospital, Shandong University, Jinan 250014, China.
authors.forename: Mujian
authors.initials: M
authors.lastname: Teng
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Shengying
authors.initials: S
authors.lastname: Qin
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Fan
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood; D016031:Liver Transplantation / Q000639:trends; D008297:Male; D008875:Middle Aged; D010105:Oxygenases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016559:Tacrolimus / Q000097:blood*; D014019:Tissue Donors
chemical_list: D007166:Immunosuppressive Agents; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); D016559:Tacrolimus
keywords: CYP-450 3A5; FMO3; pharmacogenomics; tacrolimus