title: The clinical implementation of primary HPV screening.
abstract: OBJECTIVE
  To evaluate, from a gynecology perspective, the transition from cytology-based HPV screening to primary HPV screening.
  
  
  METHODS
  Studies examining switching from cytology-based screening to primary HPV-DNA testing with triaging of patients with positive test results were retrieved and reviewed, with a particular focus on screening in an Italian setting.
  
  
  RESULTS
  The increased complexity of patient-management decisions when implementing HPV-based screening was a critical issue discussed in the literature. The change in strategy represents a paradigm shift in moving from a medical perspective of identifying the disease in individual patients, to a public-healthcare perspective of excluding HPV from the healthy population and identifying a small sub-group of individuals at increased risk of HPV.
  
  
  CONCLUSIONS
  With knowledge about HPV screening evolving rapidly, new programs and related algorithms need to be sufficiently flexible to be adjusted according to ongoing research and the validation of new assays. The establishment of a national working group (including epidemiologists, gynecologists, pathologists, and healthcare providers) will be necessary to properly implement and govern this important technical and cultural transition.
authors.affiliation: HPV Unit, Department of Gynecologic Oncology, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Mariani
authors.affiliation: Preventive Gynaecology Unit, European Institute of Oncology, Milan, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Igidbashian
authors.affiliation: Laboratory Medicine Division, European Institute of Oncology, Milan, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Sandri
authors.affiliation: Department of Medical Oncology B, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Vici
authors.affiliation: Preventive Gynaecology Unit, European Institute of Oncology, Milan, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Landoni
mesh_terms: D003127:Colposcopy; D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D014626:Vaginal Smears
keywords: Cervical cancer screening; HPV test; Primary HPV screening