title: Modes of invasion during tumour dissemination.
abstract: Cancer cell migration and invasion underlie metastatic dissemination, one of the major problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly, cancer cells can switch between invasion modes in order to cope with challenging environments. This ability to switch migratory modes or plasticity highlights the challenges behind antimetastasis therapy design. In this Review, we present current knowledge on different tumour invasion strategies, the determinants controlling plasticity and arising therapeutic opportunities. We propose that targeting master regulators controlling plasticity is needed to hinder tumour dissemination and metastasis.
authors.affiliation: Tumour Plasticity Team, Randall Division of Cell and Molecular Biophysics, King's College London, UK.
authors.forename: Pahini
authors.initials: P
authors.lastname: Pandya
authors.affiliation: Tumour Plasticity Team, Randall Division of Cell and Molecular Biophysics, King's College London, UK.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Orgaz
authors.affiliation: Tumour Plasticity Team, Randall Division of Cell and Molecular Biophysics, King's College London, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Sanz-Moreno
mesh_terms: D000205:Actomyosin / Q000378:metabolism; D000818:Animals; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000205:Actomyosin; D020741:rho GTP-Binding Proteins
keywords: Rho GTPases; actomyosin contractility; cancer metastasis; invasion; plasticity