title: A novel starch-based stimuli-responsive nanosystem for theranostic applications.
abstract: The aim of this study was to synthesis and characterization of a novel stimuli-responsive polymeric nanosystem for theranostic applications. For this purpose, starch was modified by itaconic anhydride to afford an itaconat-functionalized starch macromonomer (starch-IA). This macromonomer with carboxylic functional groups was subsequently adsorbed onto the surface of iron oxide nanoparticles (Fe3O4NPs), and then copolymerized with N-isopropylacrylamide (NIPAAm) monomer via a 'free' radical initiated polymerization technique to produce a temperature-responsive magnetic nanohydrogel (MNHG). The chemical structures of all samples as representatives were characterized by means of Fourier transform infrared (FTIR) spectroscopy. The lower critical solution temperature (LCST), thermal responsibility, morphology, elemental composition, thermal stability, and magnetic properties of the synthesized MNHG were investigated. In addition, the methotrexate (MTX)-loading capacity (∼74%) and stimuli-responsive drug release ability of the synthesized MNHG were also evaluated. As results, we envision that the synthesized starch-g-PNIPAAm/Fe3O4MNHG may be find theranostic applications, in part due to its smart physicochemical properties.
authors.affiliation: Department of Chemistry, Payame Noor University, P.O. BOX: 19395-3697, Tehran, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Poorgholy
authors.affiliation: Department of Chemistry, Payame Noor University, P.O. BOX: 19395-3697, Tehran, Iran. Electronic address: b_massoumi@pnu.ac.ir.
authors.forename: Bakhshali
authors.initials: B
authors.lastname: Massoumi
authors.affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, P.O. BOX: 51656-65811, Tabriz, Iran. Electronic address: m_jaymand@yahoo.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Jaymand
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D060328:Magnetic Phenomena; D053758:Nanoparticles / Q000737:chemistry*; D013213:Starch / Q000737:chemistry*; D013696:Temperature; D000068936:Theranostic Nanomedicine
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D005290:Ferric Compounds; D020100:Hydrogels; C000499:ferric oxide; C052970:poly-N-isopropylacrylamide; D013213:Starch
keywords: Itaconic anhydride; Magnetic nanoparticles; Poly(N-isopropylacrylamide); Starch; Stimuli-responsive systems; Theranostic application