title: Potassium Iodate Differently Regulates the Proliferation, Migration, and Invasion of Human Thyroid Cancer Cells via Modulating miR-146a.
abstract: The effects of different doses of potassium iodate (KIO3) on the malignancy of thyroid cancer were investigated. Results showed that the proliferation, migration, and invasion of SW579 thyroid cancer cells were improved by 10-6M KIO3, which was associated with microRNA(miR)-146a deficit; 10-2M KIO3significantly enhanced miR-146a level and suppressed SW579 cell proliferation, migration, and invasion. The diverse effects of KIO3on SW579 cells were associated with the expression changes in miR-146a targets, Bcl-2, Bax, and caspase-3. Our study concludes that different doses of KIO3have counteracting effects on the malignancy of thyroid cancer through modulating miR-146a level.
authors.affiliation: a Department of Oncology , The Fourth Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: b Guilin Medical College , Guilin , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: c Department of General Surgery , 303 Hospital of People's Liberation Army , Nanning , China.
authors.forename: Jiayue
authors.initials: J
authors.lastname: Zhang
authors.affiliation: d Department of Biochemistry and Molecular Biology , Harbin Medical University , Harbin , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
mesh_terms: D053148:Caspase 3 / Q000096:biosynthesis / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007452:Iodates / Q000494:pharmacology*; D035683:MicroRNAs / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D017680:Potassium Compounds / Q000494:pharmacology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis / Q000235:genetics
chemical_list: C494826:BAX protein, human; D007452:Iodates; C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D017680:Potassium Compounds; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein; D053148:Caspase 3; C039693:potassium iodate
keywords: Thyroid cancer; miR-146a; potassium iodate