title: Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies.
abstract: OBJECTIVE
  To compare serum humanin concentrations in pregnant women with and without pre-eclampsia (PE).
  
  
  METHODS
  A case-control study where pregnant women (PE group, n = 37; control group, n = 34) studied through history parameters (gynecological, obstetrical, personal, and family), physical and sonographic examination parameters [body mass index (BMI), blood pressure obstetrical ultrasound], and biochemical/hormonal assays [creatinine, urea, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), uric acid, platelets, urinary protein, and humanin].
  
  
  RESULTS
  There was no difference in basic characteristics between women with PE and control, except in parity and gravidity. Humanin concentrations were higher in women with PE compared to controls (422.2 ± 33.5 vs. 319.1 ± 28.1 pg/ml, p = 0.023). In a binary logistic analysis, humanin was associated with the presence of PE [odds ratio 1.003, 95% confidence interval (CI); 1.000-1.006]. The ability of humanin to discriminate between women with PE and controls was evaluated by receiver operation characteristics (ROC) analysis [area under the curve (AUC) 0.639, 95% CI; 0.510-0.768, p = 0.045].
  
  
  CONCLUSIONS
  Serum humanin concentrations are increased in women with PE, compared to women with uncomplicated pregnancies, suggesting a potential protective role of humanin against the oxidative stress and endothelial dysfunction occurring in PE.
authors.affiliation: a First Department of Obstetrics and Gynecology , Medical School, Aristotle University of Thessaloniki , Thessaloniki, Greece.|b Department of Gynecology , 424 Military General Hospital , Thessaloniki , Greece.
authors.forename: Panagiotis
authors.identifier: http://orcid.org/0000-0001-8220-3087
authors.initials: P
authors.lastname: Nikolakopoulos
authors.affiliation: c Laboratory of Biological Chemistry , Medical School, Aristotle University of Thessaloniki , Thessaloniki, Thessaloniki, Greece.
authors.forename: Georgios
authors.identifier: http://orcid.org/0000-0001-8339-9800
authors.initials: G
authors.lastname: Tzimagiorgis
authors.affiliation: a First Department of Obstetrics and Gynecology , Medical School, Aristotle University of Thessaloniki , Thessaloniki, Greece.
authors.forename: Dimitrios G
authors.identifier: http://orcid.org/0000-0002-5005-1995
authors.initials: DG
authors.lastname: Goulis
authors.affiliation: c Laboratory of Biological Chemistry , Medical School, Aristotle University of Thessaloniki , Thessaloniki, Thessaloniki, Greece.
authors.forename: Fani
authors.identifier: http://orcid.org/0000-0003-4695-5753
authors.initials: F
authors.lastname: Chatzopoulou
authors.affiliation: a First Department of Obstetrics and Gynecology , Medical School, Aristotle University of Thessaloniki , Thessaloniki, Greece.
authors.forename: Leonidas
authors.identifier: http://orcid.org/0000-0001-6282-1013
authors.initials: L
authors.lastname: Zepiridis
authors.affiliation: a First Department of Obstetrics and Gynecology , Medical School, Aristotle University of Thessaloniki , Thessaloniki, Greece.
authors.forename: Dimitrios
authors.identifier: http://orcid.org/0000-0001-7768-1818
authors.initials: D
authors.lastname: Vavilis
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C427211:humanin
keywords: Humanin; apoptosis; endothelial dysfunction; oxidative stress; pre-eclampsia