title: Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study.
abstract: Colorectal cancer is the third most common cancer worldwide, and many risk factors for colorectal cancer have been established. However, it remains uncertain whether psychological stress contributes to the onset of colorectal cancer. Therefore, we conducted a large-scale prospective cohort study to confirm the association between perceived stress and colorectal cancer incidence. We identified 680 cases of colon cancer and 330 cases of rectal cancer during a maximum of 21-year follow-up of 61,563 Japanese men and women. Cox regression analysis adjusted for potential confounders revealed a significant association of perceived stress with rectal cancer incidence but not with colon cancer incidence. This finding is partly consistent with that from only one previous study that addressed an association between perceived stress and the risk of colorectal cancer. However, studies on this topic are sparse and warrant further exploration.
authors.affiliation: Clinical Study Support, Inc., Nagoya, 460-0003, Japan.|Department of Public Health, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
authors.forename: Norimasa
authors.initials: N
authors.lastname: Kikuchi
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishiyama
authors.affiliation: Clinical Study Support, Inc., Nagoya, 460-0003, Japan.|Department of Public Health, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sawada
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
authors.forename: Chaochen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, 602-8566, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000523:psychology*; D003299:Cooperative Behavior; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D013315:Stress, Psychological / Q000150:complications*