title: Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies.
abstract: The p75 neurotrophin receptor (p75NTR) is a single membrane-spanning receptor in the tumor necrosis factor (TNF) death domain containing receptor family. p75NTR has multiple faces of biological or pathogenic functions by partnering with the three major neurotrophin receptors, including tropomyosin receptor kinase (Trk), sortilin and Nogo receptors. By partnering with different co-receptors, p75NTR regulates the binding of mature or pro-neurotrophins and activation of different signaling pathways, resulting in outcomes ranging from growth and survival to cell death or apoptosis. In this review, we summarized the role of p75NTR in maintaining the hemostasis of the brain, and briefly introduced its participation in the pathogenesis of several neurodegenerative diseases. The complexity of p75NTR enables it to be a potent therapeutic target of many diseases by modulating functions of the receptor.
authors.affiliation: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors.forename: Changyue
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Dayu
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors.forename: Huadong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors.forename: Yanjiang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*
chemical_list: D020800:Receptor, Nerve Growth Factor
keywords: apoptosis; brain; neurogensis; p75 neurotrophin receptor; sortilin