title: Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach.
abstract: A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin towardStaphylococcus aureusbiofilms. Several compounds were found to effectively increase the susceptibility of staphylococcal biofilms toward this glycopeptide. The most active analogue identified in this study showed an EC50value of 0.26 μM.
authors.affiliation: Laboratory for Medicinal Chemistry, Ghent University , Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
authors.forename: Arno
authors.initials: A
authors.lastname: Vermote
authors.affiliation: Laboratory for Pharmaceutical Microbiology, Ghent University , Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
authors.forename: Gilles
authors.initials: G
authors.lastname: Brackman
authors.affiliation: Laboratory for Medicinal Chemistry, Ghent University , Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
authors.forename: Martijn D P
authors.initials: MD
authors.lastname: Risseeuw
authors.affiliation: Laboratory for Microbiology, Parasitology and Hygiene, University of Antwerp , Universiteitsplein 1 (S7), B-2610 Wilrijk, Belgium.
authors.forename: Davie
authors.initials: D
authors.lastname: Cappoen
authors.affiliation: Laboratory for Microbiology, Parasitology and Hygiene, University of Antwerp , Universiteitsplein 1 (S7), B-2610 Wilrijk, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
authors.affiliation: Laboratory for Pharmaceutical Microbiology, Ghent University , Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Coenye
authors.affiliation: Laboratory for Medicinal Chemistry, Ghent University , Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
authors.forename: Serge
authors.initials: S
authors.lastname: Van Calenbergh
keywords: Antibiotic potentiators; Staphylococcus aureus; biofilms; hamamelitannin analogues; quorum sensing