title: Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases.
abstract: OBJECTIVE
  This study aimed to evaluate the progress of future liver remnant volume (FLRV) in patients with liver metastases after portal vein embolization (PVE) with the application of hematopoietic stem cells (HSCs) and compare it with a patients control group after PVE only.
  
  
  METHODS
  Twenty patients (group 1) underwent PVE with contralateral HSC application. Subsequently, CT volumetry with the determination of FLRV was performed at weekly intervals, in total three weeks. A sample of twenty patients (group 2) who underwent PVE without HSC application was used as a control group.
  
  
  RESULTS
  The mean of FLRV increased by 173.2 mL during three weeks after the PVE/HSC procedure, whereas by 98.9 mL after PVE only (p = 0.015). Furthermore, the mean daily growth of FLRV by 7.6 mL in group 1 was significantly higher in comparison with 4.1 mL in group 2 (p = 0.007).
  
  
  CONCLUSIONS
  PVE with the application of HSC significantly facilitates growth of FLRV in comparison with PVE only. This method could be one of the new suitable approaches to increase the resectability of liver tumours.
authors.affiliation: Department of Imaging Methods, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic. ludvikj@fnplzen.cz.|, alej Svobody 80, 30460, Plzeň, Czech Republic. ludvikj@fnplzen.cz.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Ludvík
authors.affiliation: Department of Imaging Methods, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Duras
authors.affiliation: Department of Surgery, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Třeška
authors.affiliation: Department of Imaging Methods, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Táňa
authors.initials: T
authors.lastname: Matoušková
authors.affiliation: Department of Surgery, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Brůha
authors.affiliation: Department of Surgery, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichtl
authors.affiliation: Department of Haemato-Oncology, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lysák
authors.affiliation: Department of Imaging Methods, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Ferda
authors.affiliation: Department of Imaging Methods, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Baxa
mesh_terms: D000368:Aged; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy*; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
keywords: CT liver volumetry; Future liver remnant volume; Hematopoietic stem cells; Liver resection; Portal vein embolization