title: Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.
abstract: A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.
authors.affiliation: Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Suga
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Narusawa
authors.affiliation: Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.|Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Iwatsuki
authors.affiliation: Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.|Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.affiliation: Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.|Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakashima
authors.affiliation: Institute for Genome Research, Tokushima University, Tokushima, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shinohara
authors.affiliation: Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, Ibaraki, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiotsuki
authors.affiliation: Faculty of Bioenvironmental Science, Kyoto Gakuen University, Kyoto, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Ichimaru
authors.affiliation: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyoshi
authors.affiliation: Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.|Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Asami
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ōmura
authors.affiliation: Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.|Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
mesh_terms: D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D001230:Aspergillus / Q000737:chemistry / Q000145:classification; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry* / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010575:Pesticides / Q000737:chemistry / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
chemical_list: D009281:Naphthalenes; D010575:Pesticides; C000618133:decatamariic acid; D000255:Adenosine Triphosphate