title: Interplay between Myeloid Cells and Humoral Innate Immunity.
abstract: The innate immune system represents the first line of defense against pathogens and comprises both a cellular and a humoral arm. Fluid-phase pattern recognition molecules (PRMs), which include collectins, ficolins, and pentraxins, are key components of the humoral arm of innate immunity and are expressed by a variety of cells, including myeloid, epithelial, and endothelial cells, mainly in response to infectious and inflammatory conditions. Soluble PRMs share basic multifunctional properties including activation and regulation of the complement cascade, opsonization of pathogens and apoptotic cells, regulation of leukocyte extravasation, and fine-tuning of inflammation. Therefore, soluble PRMs are part of the immune response and retain antibody-like effector functions. Here, we will review the expression and general function of soluble PRMs, focusing our attention on the long pentraxin PTX3.
authors.affiliation: Humanitas Clinical Research Center.|Humanitas University, 20089, Rozzano (Milano), Italy.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Jaillon
authors.affiliation: Humanitas Clinical Research Center.|*Present address: Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4QL, United Kingdom.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bonavita
authors.affiliation: Humanitas Clinical Research Center.|Humanitas University, 20089, Rozzano (Milano), Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
authors.affiliation: Humanitas Clinical Research Center.|Humanitas University, 20089, Rozzano (Milano), Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate; D037102:Lectins / Q000378:metabolism*; D022423:Myeloid Cells / Q000276:immunology*
chemical_list: D037102:Lectins; D002097:C-Reactive Protein