title: Post-Translational Modifications of the TAK1-TAB Complex.
abstract: Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors and cytokines such as TGF-β, IL-1β, and TNF-α, and mediates a wide range of biological processes through activation of the nuclear factor-κB (NF-κB) and the mitogen-activated protein (MAP) kinase signaling pathways. It is well established that activation status of TAK1 is tightly regulated by forming a complex with its binding partners, TAK1-binding proteins (TAB1, TAB2, and TAB3). Interestingly, recent evidence indicates the importance of post-translational modifications (PTMs) of TAK1 and TABs in the regulation of TAK1 activation. To date, a number of PTMs of TAK1 and TABs have been revealed, and these PTMs appear to fine-tune and coordinate TAK1 activities depending on the cellular context. This review therefore focuses on recent advances in the understanding of the PTMs of the TAK1-TAB complex.
authors.affiliation: Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. y-hirata@m.tohoku.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirata
authors.affiliation: Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. miki.t@dc.tohoku.ac.jp.
authors.forename: Miki
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. tmrst.1119@gmail.com.
authors.forename: Tohru
authors.initials: T
authors.lastname: Morishita
authors.affiliation: Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. noguchi@m.tohoku.ac.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Noguchi
authors.affiliation: Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. matsushi@m.tohoku.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Matsuzawa
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism*; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D000099151:MAP Kinase Kinase Kinase 7
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D020930:MAP Kinase Kinase Kinases; D000099151:MAP Kinase Kinase Kinase 7
keywords: MAP kinase; NF-κB; TAB1; TAB2; TAB3; TAK1; post-translational modification