title: Oxidation-Reduction Condensation of Diazaphosphites for Carbon-Heteroatom Bond Formation Based on Mitsunobu Mechanism.
abstract: An efficient oxidation-reduction condensation reaction of diazaphosphites with various nonacidic pronucleophiles in the presence of DIAD as a weak oxidant has been developed for carbon-heteroatom bond formation. This mild process affords structurally diverse tertiary amines, secondary amines, esters, ethers, and thioethers in moderate to excellent yields. The selective synthesis of secondary amines from primary amines has been achieved. Importantly, a practical application to the synthesis of antiparkinsonian agent piribedil has been demonstrated.
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 South Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.|Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , No. 30 Puzhu Road (S), Nanjing 211816, People's Republic of China.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 South Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Jun Yong
authors.identifier: 0000-0002-9732-1454
authors.initials: JY
authors.lastname: Kang