title: Research and development on lactoferrin and its derivatives in China from 2011-2015.
abstract: Lactoferrin (Lf), a multifunctional glycoprotein, is an important antimicrobial and immune regulatory protein present in neutrophils and most exocrine secretions of mammals. Lactoferricin (Lfcin) is located in the N-terminal region of this protein. In this review, the current state of research into Lf and Lfcin in China is described. Searching with HistCite software in Web Sci located 118 papers published by Chinese researchers from 2011-2015, making China one of the top 3 producers of Lf research and development in the world. The biological functions of Lf and Lfcin are discussed, including antibacterial, antiviral, antifungal, anticarcinogenic, and anti-inflammatory activities; targeted drug delivery, induction of neurocyte, osteoblast, and tenocyte growth, and possible mechanisms of action. The preparation and heterologous expression of Lf in animals, bacteria, and yeast are discussed in detail. Five Lf-related food additive factories and 9 Lf-related health food production companies are certified by the China Food and Drug Administration (CFDA). The latest progress in the generation of transgenic livestock in China, the safety of the use of transgenic animals, and future prospects for the uses of Lf and Lfcin are also covered.
authors.affiliation: a Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, P.R. China.|b Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, P.R. China.|b Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
authors.forename: Xiumin
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, P.R. China.|b Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Hao
authors.affiliation: a Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, P.R. China.|b Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
authors.forename: Da
authors.initials: D
authors.lastname: Teng
authors.affiliation: a Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, P.R. China.|b Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D035843:Biomedical Research; D002417:Cattle; D002681:China; D006801:Humans; D007781:Lactoferrin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; C082171:lactoferricin B; D007781:Lactoferrin
keywords: application; biological function; expression; fonction biologique; lactoferricin; lactoferricine; lactoferrin; lactoferrine