title: Cancer cells activate damage-tolerant and error-prone DNA synthesis.
abstract: Trans-lesion synthesis (TLS) is a DNA damage-tolerant and error-prone mode of DNA replication. Recent work shows that many cancer cells coopt an aberrantly expressed germ cell protein, melanoma antigen-A4 (MAGE-A4), to activate TLS. MAGE-A4-induced "pathological TLS" provides a potential mechanism through which neoplastic cells can tolerate intrinsic and therapeutic genotoxicity while acquiring mutability.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Mutter-Rottmayer
authors.affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
authors.forename: Yanzhe
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Vaziri
keywords: Cancer-testes antigens (CTA); DNA damage; RAD18; genome maintenance; melanoma antigen-A4 (MAGE-A4); mutagenesis; trans-lesion synthesis (TLS)