title: Mathematical Modeling of Rotary Blood Pumps in a Pulsatile In Vitro Flow Environment.
abstract: Nowadays, sacrificing animals to develop medical devices and receive regulatory approval has become more common, which increases ethical concerns. Although in vivo tests are necessary for development and evaluation of new devices, nonetheless, with appropriate in vitro setups and mathematical models, a part of the validation process can be performed using these models to reduce the number of sacrificed animals. The main aim of this study is to present a mathematical model simulating the hydrodynamic function of a rotary blood pump (RBP) in a pulsatile in vitro flow environment. This model relates the pressure head of the RBP to the flow rate, rotational speed, and time derivatives of flow rate and rotational speed. To identify the model parameters, an in vitro setup was constructed consisting of a piston pump, a compliance chamber, a throttle, a buffer reservoir, and the CentriMag RBP. A 40% glycerin-water mixture as a blood analog fluid and deionized water were used in the hydraulic circuit to investigate the effect of viscosity and density of the working fluid on the model parameters. First, model variables were physically measured and digitally acquired. Second, an identification algorithm based on regression analysis was used to derive the model parameters. Third, the completed model was validated with a totally different set of in vitro data. The model is usable for both mathematical simulations of the interaction between the pump and heart and indirect pressure measurement in a clinical context.
authors.affiliation: University of Bern, Bern, Switzerland.
authors.forename: Tohid
authors.initials: T
authors.lastname: Pirbodaghi
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006353:Heart-Assist Devices; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011673:Pulsatile Flow
keywords: Dynamic identification; In-vitro study; Rotary blood pumps