title: Breaking the ice: urine proteomics of medullary sponge kidney disease.
abstract: Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinically compatible enzyme-linked immunosorbent assay. The neglected issue of stone pathogenesis was also evidenced. This commentary discusses several considerations in biomarker validation, and how urinary proteomics breaks new ground in MSK research.
authors.affiliation: Pediatric Translational Research Unit, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand. Electronic address: schuti.rama@gmail.com.
authors.forename: Somchai
authors.initials: S
authors.lastname: Chutipongtanate
mesh_terms: D015415:Biomarkers; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007691:Medullary Sponge Kidney; D040901:Proteomics
chemical_list: D015415:Biomarkers
keywords: biomarker; medullary sponge kidney; renal stone; urine