title: Reduced effects of age on dopamine D2 receptor levels in physically active adults.
abstract: Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.
authors.affiliation: Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA. Electronic address: linh.dang@vanderbilt.edu.
authors.forename: Linh C
authors.initials: LC
authors.lastname: Dang
authors.affiliation: Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA.
authors.forename: Jaime J
authors.initials: JJ
authors.lastname: Castrellon
authors.affiliation: Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA.
authors.forename: Scott F
authors.initials: SF
authors.lastname: Perkins
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA.
authors.forename: Nam T
authors.initials: NT
authors.lastname: Le
authors.affiliation: Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Ave South, Nashville, TN 37212, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA.
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Cowan
authors.affiliation: Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA; Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Ave South, Nashville, TN 37212, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Zald
authors.affiliation: Department of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, CT 06520, USA. Electronic address: g.samanezlarkin@duke.edu.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Samanez-Larkin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001549:Benzamides; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development / Q000502:physiology; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2 / Q000378:metabolism / Q000502:physiology*; D050637:Receptors, Dopamine D3 / Q000378:metabolism; D055815:Young Adult
chemical_list: D001549:Benzamides; C581293:DRD2 protein, human; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C574003:fallypride
keywords: Aging; Dopamine; Physical activity