title: Regression of intracranial meningioma following treatment with nivolumab: Case report and review of the literature.
abstract: The treatment of refractory meningiomas remains a challenge for both neurosurgeons and neuro-oncologists. There have been no clinical reports of the use or effects of anti-PD-1 therapy in patients with meningioma. We describe a patient whose intracranial meningioma decreased significantly in size after treatment with nivolumab, a monoclonal antibody targeting PD-1, for a concomitant advanced lung cancer. This is the first clinical report suggesting that antibodies targeting PD-1 are effective in treating meningioma. It should encourage further research into the use of checkpoint inhibitors in meningioma.
authors.affiliation: Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Efrat
authors.initials: E
authors.lastname: Gelerstein
authors.affiliation: Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Assaf
authors.initials: A
authors.lastname: Berger
authors.affiliation: Imaging Division, Neuroradiology Unit, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Tali
authors.initials: T
authors.lastname: Jonas-Kimchi
authors.affiliation: Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Ido
authors.initials: I
authors.lastname: Strauss
authors.affiliation: Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Kanner
authors.affiliation: Neuro-oncology Service, Division of Oncology, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Deborah T
authors.initials: DT
authors.lastname: Blumenthal
authors.affiliation: Oncology Department, Meir Medical Center, Kfar Saba, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Gottfried
authors.affiliation: Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Nevo
authors.initials: N
authors.lastname: Margalit
authors.affiliation: Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors.forename: Zvi
authors.initials: Z
authors.lastname: Ram
authors.affiliation: Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel. Electronic address: talsh5@gmail.com.
authors.forename: Tal
authors.initials: T
authors.lastname: Shahar
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008579:Meningioma / Q000188:drug therapy*; D000077594:Nivolumab
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000077594:Nivolumab
keywords: Anti-PD-1; Brain tumor; Checkpoint inhibitor; Meningioma; Nivolumab