title: Palladium(II)-Catalyzed Intramolecular Oxidative C-H/C-H Cross-Coupling Reaction of C3,N-Linked Biheterocycles: Rapid Access to Polycyclic Nitrogen Heterocycles.
abstract: A Pd(II)-catalyzed intramolecular oxidative C-H/C-H cross-coupling has been developed for the direct construction of valuable polycyclic heteroarene scaffolds. From a retrosynthetic point of view, the strategic formation of a C-C bond via C(sp2)-H/C(sp2)-H dehydrogenative coupling across C3,N-linked biheterocyclic precursors may be useful in de novo syntheses of indole-derived natural products and pharmaceuticals. The reaction exhibited good functional group/heterocycle tolerance, and a proposed mechanism involving an azoylpalladium complex is also supported.
authors.affiliation: Department of Biomolecular Sciences, Section of Organic Chemistry and Organic Natural Compounds, University of Urbino "Carlo Bo" , Via I Maggetti 24, 61029 Urbino, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Mantenuto
authors.affiliation: Department of Biomolecular Sciences, Section of Organic Chemistry and Organic Natural Compounds, University of Urbino "Carlo Bo" , Via I Maggetti 24, 61029 Urbino, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Ciccolini
authors.affiliation: Department of Biomolecular Sciences, Section of Chemistry, University of Urbino "Carlo Bo" , Piazza Rinascimento 6, 61029 Urbino, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Lucarini
authors.affiliation: Department of Biomolecular Sciences, Section of Chemistry, University of Urbino "Carlo Bo" , Piazza Rinascimento 6, 61029 Urbino, Italy.
authors.forename: Giovanni
authors.identifier: 0000-0003-0418-7143
authors.initials: G
authors.lastname: Piersanti
authors.affiliation: Department of Biomolecular Sciences, Section of Organic Chemistry and Organic Natural Compounds, University of Urbino "Carlo Bo" , Via I Maggetti 24, 61029 Urbino, Italy.
authors.forename: Gianfranco
authors.identifier: 0000-0003-3112-819X
authors.initials: G
authors.lastname: Favi
authors.affiliation: Department of Biomolecular Sciences, Section of Organic Chemistry and Organic Natural Compounds, University of Urbino "Carlo Bo" , Via I Maggetti 24, 61029 Urbino, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Mantellini