title: Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography.
abstract: The choriocapillaris plays an important role in supporting the metabolic demands of the retina. Studies of the choriocapillaris in disease states with optical coherence tomography angiography (OCTA) have proven insightful. However, image artifacts complicate the identification and quantification of the choriocapillaris in degenerative diseases such as choroideremia. Here, we demonstrate a supervised machine learning approach to detect intact choriocapillaris based on training with results from an expert grader. We trained a random forest classifier to evaluateen facestructural OCT and OCTA information along with spatial image features. Evaluation of the trained classifier using previously unseen data showed good agreement with manual grading.
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Gao
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA.
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Patel
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA; Department of Ophthalmology, Emory University, 1365B Clifton Rd, Atlanta, GA 30322, USA.
authors.forename: Nieraj
authors.initials: N
authors.lastname: Jain
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Weleber
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA.
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Pennesi
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97205, USA.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
keywords: (100.0100) Image processing; (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170.4470) Ophthalmology