title: Sensitive and Fast Humidity Sensor Based on A Redox Conducting Supramolecular Ionic Material for Respiration Monitoring.
abstract: Real-time monitoring of respiratory rate (RR) is highly important for human health, clinical diagnosis, and fundamental scientific research. Exhaled humidity-based RR monitoring has recently attracted increased attention because of its accuracy and portability. Here, we report a new design of an exhaled humidity sensor for the real-time monitoring of the RR based on a synthetic redox conducting supramolecular ionic material (SIM). The humidity-dependent conducting SIM is prepared by ionic self-assembly in aqueous solutions of electroactive 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,10-bis(3-methylimidazolium-1-yl) decane (C10(mim)2). By taking full advantage of the high hygroscopicity and water stability arising from the ionic and hydrophobic interactions between two building blocks (i.e., ABTS and C10(mim)2), the SIM-based humidity sensor exhibits both high sensitivity (less than 0.1% relative humidity) and fast response time (∼37 ms). These excellent properties allow this humidity sensor to noninvasively monitor the RRs of not only humans but also rats that have a much faster RR and much smaller tidal volume than humans. Moreover, this sensor could also be efficiently used for the real-time monitoring of the recovery process of rats from anesthesia.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences (CAS) , Beijing 100190, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Yan
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences (CAS) , Beijing 100190, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences (CAS) , Beijing 100190, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences (CAS) , Beijing 100190, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Lanqun
authors.identifier: 0000-0001-8286-9321
authors.initials: L
authors.lastname: Mao
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D006801:Humans; D006813:Humidity; D057927:Hydrophobic and Hydrophilic Interactions; D007477:Ions / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry; D008297:Male; D008991:Monitoring, Physiologic; D010084:Oxidation-Reduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D056152:Respiratory Rate; D013997:Time Factors
chemical_list: D007477:Ions; D046911:Macromolecular Substances