title: European consensus conference on faecal microbiota transplantation in clinical practice.
abstract: Faecal microbiota transplantation (FMT) is an important therapeutic option forClostridium difficileinfection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment ofC. difficileinfection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.
authors.affiliation: Department of Gastroenterological Area, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cammarota
authors.affiliation: Department of Gastroenterological Area, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ianiro
authors.affiliation: Department of Internal Medicine I, Gastroenterology, Endocrinology & Metabolism, Medical University, Innsbruck, Austria.
authors.forename: Herbert
authors.initials: H
authors.lastname: Tilg
authors.affiliation: Faculty of Technology and Metallurgy, Department of Biochemical Engineering and Biotechnology, University of Belgrade, Belgrade, Serbia.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Rajilić-Stojanović
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University, Graz, Austria.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Kump
authors.affiliation: Faculty of Medicine, Immunobiology Research Program, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
authors.forename: Reetta
authors.initials: R
authors.lastname: Satokari
authors.affiliation: Gastroenterology and Nutrition Department, AP-HP, French Group of Faecal Microbiota Transplantation (GFTF), Saint-Antoine Hospital and UPMC Paris 06, Paris, France.
authors.forename: Harry
authors.initials: H
authors.lastname: Sokol
authors.affiliation: Department of Clinic of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Perttu
authors.initials: P
authors.lastname: Arkkila
authors.affiliation: Tissues and Cells Area, Italian National Transplant Center (CNT), Rome, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Pintus
authors.affiliation: Department of Gastroenterology, St. Mark's Hospital, London, UK.
authors.forename: Ailsa
authors.initials: A
authors.lastname: Hart
authors.affiliation: Department of Gastroenterology, St. Mark's Hospital, London, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Segal
authors.affiliation: Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University, Rome, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Aloi
authors.affiliation: Laboratory of Microbiology, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Masucci
authors.affiliation: Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden.
authors.forename: Antonio
authors.initials: A
authors.lastname: Molinaro
authors.affiliation: Department of Gastroenterological Area, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Scaldaferri
authors.affiliation: Department of Gastroenterological Area, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gasbarrini
authors.affiliation: Gastroenterology and Hepatology Service, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Sanroman
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Link
authors.affiliation: Department of Internal Medicine, Academic University Medical Center, Amsterdam, The Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: de Groot
authors.affiliation: Faculty of Medicine, Immunobiology Research Program, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.|Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
authors.forename: Willem M
authors.initials: WM
authors.lastname: de Vos
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University, Graz, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Högenauer
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
authors.affiliation: Department of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Mattila
authors.affiliation: Clinic for Gastroenterology and Hepatology, University of Belgrade and School of Medicine, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Tomica
authors.initials: T
authors.lastname: Milosavljević
authors.affiliation: Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden.|Department of Internal Medicine, Academic University Medical Center, Amsterdam, The Netherlands.|Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Max
authors.initials: M
authors.lastname: Nieuwdorp
authors.affiliation: Laboratory of Microbiology, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sanguinetti
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Simren
authors.affiliation: Department of Gastroenterological Area, "A. Gemelli" Hospital, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
mesh_terms: D016360:Clostridioides difficile; D046148:Donor Selection; D004761:Enterocolitis, Pseudomembranous / Q000628:therapy*; D005060:Europe; D019317:Evidence-Based Medicine; D000069467:Fecal Microbiota Transplantation / Q000009:adverse effects / Q000379:methods / Q000592:standards; D006268:Health Facilities; D006757:Hospital Units / Q000458:organization & administration; D006801:Humans; D018579:Patient Selection; D013048:Specimen Handling / Q000379:methods*
keywords: CLINICAL DECISION MAKING; DIARRHOEAL DISEASE; ENTERIC BACTERIAL MICROFLORA