title: Pinus DensifloraBark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue.
abstract: PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, antiinflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-week-old male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group (p< 0.05 andp< 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and low-density lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group (p< 0.01). Acetyl CoA carboxylase (p< 0.01), elongase of very long chain fatty acids 6 (p< 0.01), stearoyl CoA desaturase 1 (p< 0.05), microsomal triglyceride transfer protein (p< 0.01), and sterol regulatory element-binding protein 1 (p< 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAATenhancer-binding protein alpha (p< 0.05), peroxisome proliferator-activated receptor gamma (p< 0.001), and perilipin (p< 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue.
authors.affiliation: Department of Foods and Nutrition, Kookmin University, Seoul 02707, Republic of Korea.
authors.forename: Hyemyoung
authors.initials: H
authors.lastname: Ahn
authors.affiliation: Department of Foods and Nutrition, Kookmin University, Seoul 02707, Republic of Korea.
authors.forename: Gwang-Woong
authors.initials: GW
authors.lastname: Go
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects*; D052436:Adipose Tissue, White / Q000187:drug effects*; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D059305:Diet, High-Fat; D015536:Down-Regulation; D005227:Fatty Acids / Q000737:chemistry; D050155:Lipogenesis / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000517:prevention & control; D047495:PPAR gamma / Q000378:metabolism; D000070778:Perilipin-1 / Q000378:metabolism; D028223:Pinus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D022762:CCAAT-Enhancer-Binding Proteins; D008078:Cholesterol, LDL; D005227:Fatty Acids; D047495:PPAR gamma; D000070778:Perilipin-1; D010936:Plant Extracts; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D002784:Cholesterol; D000103:Acetyl-CoA Carboxylase
keywords: PineXol; adipogenesis; anti-obesity; hepatic lipogenesis