title: Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
abstract: OBJECTIVE
  The aim of this study was to discriminate mole pregnancies and invasive forms among cases with first trimester vaginal bleeding by the utilization of some complete blood count parameters conjunct to sonographic findings and beta human chorionic gonadotropin concentration.
  
  
  METHODS
  Consecutive 257 cases with histopathologically confirmed mole pregnancies and 199 women without mole pregnancy presented with first trimester vaginal bleeding who admitted to Zeynep Kamil Women and Children's Health Training Hospital between January 2012 and January 2016 were included in this cross-sectional study. The serum beta HCG level at presentation, and beta hCG levels at 1st, 2nd and 3rd weeks of postevacuation with some parameters of complete blood count were utilized to discriminate cases with molar pregnancy and cases with invasive mole among first trimester pregnants presented with vaginal bleeding and abnormal sonographic findings.
  
  
  RESULTS
  Levels of beta hCG at baseline (AUC = 0.700, p < 0.05) and 1st (AUC = 0.704, p < 0.05), 2nd (AUC = 0.870, p < 0.001) and 3rd (AUC = 0.916, p < 0.001) weeks of postevacuation period were significant predictors for the cases with persistent disease. While area under curve for mean platelet volume is 0.715, it means that mean platelet volume has 21.5% additional diagnostic value for predicting persistency in molar patients. For 8.55 cut-off point for mean platelet volume, sensitivity is 84.6% and specificity is 51.6%. Area under curve for platelet/lymphocyte ratio is 0.683 means that platelet/lymphocyte ratio has additional 18.3% diagnostic value. For 102.25 cut-off point sensitivity is 86.6% and specificity is 46.2.
  
  
  CONCLUSIONS
  Simple, widely available complete blood count parameters may be used as an adjunct to other risk factors to diagnose molar pregnancies and predict postevacuation trophoblastic disease.
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Abide Yayla
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Enis
authors.initials: E
authors.lastname: Özkaya
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Ilter
authors.initials: I
authors.lastname: Yenidede
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Eser
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Evrim Bostancı
authors.initials: EB
authors.lastname: Ergen
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Ahter Tanay
authors.initials: AT
authors.lastname: Tayyar
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Mehmet Baki
authors.initials: MB
authors.lastname: Şentürk
authors.affiliation: a Department of Obstetrics and Gynaecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , Istanbul , Turkey.
authors.forename: Ates
authors.initials: A
authors.lastname: Karateke
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000097:blood / Q000209:etiology; D014594:Uterine Neoplasms / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human
keywords: Mole pregnancy; gestational trophoblastic disease; mean platelet volume; white blood cell count