title: Potential importance of B cells in aging and aging-associated neurodegenerative diseases.
abstract: Our understanding of B cells as merely antibody producers is slowly changing. Alone or in concert with antibody, they control outcomes of seemingly different diseases such as cancer, rheumatoid arthritis, diabetes, and multiple sclerosis. While their role in activation of effector immune cells is beneficial in cancer but bad in autoimmune diseases, their immunosuppressive and regulatory subsets (Bregs) inhibit autoimmune and anticancer responses. These pathogenic and suppressive functions are not static and appear to be regulated by the nature and strength of inflammation. Although aging increases inflammation and changes the composition and function of B cells, surprisingly, little is known whether the change affects aging-associated neurodegenerative disease, such as Alzheimer's disease (AD). Here, by analyzing B cells in cancer and autoimmune and neuroinflammatory diseases, we elucidate their potential importance in AD and other aging-associated neuroinflammatory diseases.
authors.affiliation: Immunoregulation section, National Institute on Aging, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA. biragyna@mail.nih.gov.
authors.forename: Arya
authors.initials: A
authors.lastname: Biragyn
authors.affiliation: Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Aliseychik
authors.affiliation: Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, USA.|Department of Genomics and Human Genetics, Russian Academy of Sciences, Institute of General Genetics, Moscow, Russia.|Center for Brain Neurobiology and Neurogenetics, Siberian Branch of the Russian Academy of Sciences, Institute of Cytology and Genetics, Novosibirsk, Russia.
authors.forename: Evgeny
authors.initials: E
authors.lastname: Rogaev
mesh_terms: D000375:Aging / Q000276:immunology* / Q000378:metabolism*; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D007249:Inflammation / Q000150:complications; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D007136:Immunoglobulins
keywords: Alzheimer’s disease; B-cell; Bregs; Neurodegeneration