title: Visible-Light-Mediated Remote Aliphatic C-H Functionalizations through a 1,5-Hydrogen Transfer Cascade.
abstract: A redox-neutral, light-mediated functionalization of unactivated C(sp3)-H bonds via iminyl radicals is presented here. A 1,5-H transfer followed by the functionalization of a C(sp2)-H bond takes place in aqueous media producing a variety of elaborated fused ketones. Mechanistic investigations have revealed 1,5-H transfer as the reversible, rate-determining step in this transformation. Divergent scaffolds are also accessible via C(sp3)-N bond formation upon a careful choice of the reaction additives.
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
authors.forename: Wei
authors.initials: W
authors.lastname: Shu
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
authors.forename: Cristina
authors.initials: C
authors.lastname: Nevado
keywords: 1,5-H transfer; C−H functionalization; dihydro-2H-pyrrole; photoredox reactions; tetralone