title: Antibiotic Coating of the Artificial Urinary Sphincter (AMS 800): Is it Worthwhile?
abstract: To investigate the impact of the antibiotic coating InhibiZone on the infection and explantation rates of the AMS 800 in comparison to the AMS 800 without InhibiZone.
  
  
  
  We retrospectively identified 305 patients with an AMS 800 in a multicenter cohort study. Patients were subsequently divided into InhibiZone and without InhibiZone-coated groups. Infection and explantation rates were analyzed by univariate and consecutively by multivariate logistic regression adjusted to variable risk factors. The infection-free interval was estimated by Kaplan-Meier plot and compared by the log-rank test. A P value below .05 was considered statistically significant.
  
  
  
  We identified 47 patients with InhibiZone and 258 without InhibiZone coating. In univariate analysis, we could not identify a significant difference in infection (P = .932) or explantation (P = .715) rates between the groups. In multivariate analysis, impaired wound healing (P = .008) and urethral erosion (P < .001) were independent predictors for infection. The InhibiZone coating neither demonstrated significant influence on the infection rate (P = .534) nor on the explantation rate (P = .214). There was no significant difference in estimated infection-free survival between the groups (P = .265).
  
  
  
  The antibiotic coating of the AMS 800 had no significant impact on infection or explantation rates in our cohort.
authors.affiliation: Department of Urology and Pediatric Urology, University Medical Center of Johannes Gutenberg University, Mainz, Germany. Electronic address: tanja.huesch@unimedizin-mainz.de.
authors.forename: Tanja
authors.initials: T
authors.lastname: Hüsch
authors.affiliation: Department of Urology, Ludwig-Maximilians-University, Campus Großhadern, Munich, Germany; Vancouver Prostate Center, University of British Columbia, Vancouver, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kretschmer
authors.affiliation: Department of Urology, University Hospital Frankfurt, Frankfurt, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Thomsen
authors.affiliation: Department of Urology, University Hospital Frankfurt, Frankfurt, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Kronlachner
authors.affiliation: Department of Urology and Pediatric Urology, University Medical Center of Johannes Gutenberg University, Mainz, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Kurosch
authors.affiliation: Department of Urology, St. Bernward Hospital Hildesheim, Hildesheim, Germany.
authors.forename: Alice
authors.initials: A
authors.lastname: Obaje
authors.affiliation: Department of Urology and Pediatric Urology, University Hospital Bonn, Bonn, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Anding
authors.affiliation: Department of Urology, Asklepios Hospital West Hamburg, Hamburg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Pottek
authors.affiliation: Department of Urology and Pediatric Urology, Helios Hospital Duisburg, Duisburg, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Rose
authors.affiliation: Department of Urology, Hospital Lüneburg, Lüneburg, Germany.
authors.forename: Roberto
authors.initials: R
authors.lastname: Olianas
authors.affiliation: Department of Urology, Göttlicher Heiland Vienna, Vienna, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Friedl
authors.affiliation: Department of Urology, Hospital Weinviertel Korneuburg, Korneuburg, Austria.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Hübner
authors.affiliation: Department of Urology and Pediatric Urology, St. Barbara Hospital Hamm GmbH, Hamm, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Homberg
authors.affiliation: Department of Urology, Evangelic Hospital Bielefeld, Bielefeld, Germany.
authors.forename: Jesco
authors.initials: J
authors.lastname: Pfitzenmaier
authors.affiliation: Department of Urology and Pediatric Urology, Helios Hospital Schwelm, Schwelm, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Grein
authors.affiliation: Department of Urology, University Hospital Muenster, Muenster, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Queissert
authors.affiliation: Department of Urology and Pediatric Urology, University Hospital Kiel, Kiel, Germany.
authors.forename: Carsten M
authors.initials: CM
authors.lastname: Naumann
authors.affiliation: Department of Urology and Pediatric Urology, Catholic Hospital St. Johann Nepomuk, Erfurt, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Schweiger
authors.affiliation: Department of Urology, Diakonie Hospital Stuttgart, Stuttgart, Germany.
authors.forename: Carola
authors.initials: C
authors.lastname: Wotzka
authors.affiliation: Department of Urology and Pediatric Urology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Joanne
authors.initials: J
authors.lastname: Nyarangi-Dix
authors.affiliation: Department of Urology, Diakonie Hospital Schwäbisch Hall, Schwäbisch Hall, Germany.
authors.forename: Torben
authors.initials: T
authors.lastname: Hofmann
authors.affiliation: Institute of medical Statistic and Epidemiology, Technical University Munich, Munich, Germany.
authors.forename: Kurt
authors.initials: K
authors.lastname: Ulm
authors.affiliation: Department of Urology, Ludwig-Maximilians-University, Campus Großhadern, Munich, Germany.
authors.forename: Ricarda M
authors.initials: RM
authors.lastname: Bauer
authors.affiliation: Department of Urology and Pediatric Urology, University Medical Center of Johannes Gutenberg University, Mainz, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Haferkamp
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D000069451:Long Term Adverse Effects / Q000175:diagnosis / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000517:prevention & control; D018570:Risk Assessment; D012307:Risk Factors; D014549:Urinary Incontinence / Q000628:therapy; D016741:Urinary Sphincter, Artificial / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible