title: Benefit of Leukocyte- and Platelet-Rich Plasma in Operative Wound Closure in Oral and Maxillofacial Surgery.
abstract: This article reports the influence of an autologous leukocyte- and platelet-rich plasma (L-PRP) injection as a minimally invasive method on supporting wound healing processes after a mandibular odontogenic cystectomy and double mandibular fracture fixation. 113 patients were enrolled into a control group (received no L-PRP injection) and 102 patients were enrolled into an L-PRP group with an oral mucosa incision. 18 patients after a double mandibular fracture were operated on using 2 external submandibular approaches receiving no fluids in the right site (a control group) and an L-PRP injection in the left incision (L-PRP group). Clinical observations showed that the oral mucosa healed faster in patients treated with L-PRP, in comparison to cases where inductive biomaterial was not added. Pain at the L-PRP injection site was relieved within few hours after an operation in patients with double mandibular fractures. However, there were no differences observed in the progression of the healing process. L-PRP possesses inductive properties that could stimulate healing processes and it seems to be one of the most promising methods in the future for the treatment of soft tissue defects.
authors.affiliation: Department of Maxillofacial Surgery, Medical University of Silesia, Sosnowiec, Poland.
authors.forename: Agata
authors.identifier: 0000-0003-1111-2967
authors.initials: A
authors.lastname: Cieślik-Bielecka
authors.affiliation: Burn Wound Unit, Burn Center, Siemianowice Slaskie, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Glik
authors.affiliation: Orthopedic Surgery and Traumatology Department, Medical University of Białystok, Białystok, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Skowroński
authors.affiliation: Department and Clinic of Orthopaedics, Trauma and Reconstructive Surgery, Trauma Center St. Barbara Hospital, Medical University of Silesia, Sosnowiec, Poland.
authors.forename: Tomasz
authors.identifier: 0000-0003-1712-7203
authors.initials: T
authors.lastname: Bielecki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001861:Bone Regeneration / Q000187:drug effects; D005260:Female; D005592:Fracture Fixation; D006801:Humans; D017708:Leukocyte Transfusion; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma / Q000378:metabolism*; D011183:Postoperative Complications / Q000473:pathology / Q000628:therapy*; D013515:Surgery, Oral; D058106:Wound Closure Techniques; D014945:Wound Healing / Q000187:drug effects*