title: Molecular genetics of human obesity: A comprehensive review.
abstract: Obesity and its related health complications is a major problem worldwide. Hypothalamus and their signalling molecules play a critical role in the intervening and coordination with energy balance and homeostasis. Genetic factors play a crucial role in determining an individual's predisposition to the weight gain and being obese. In the past few years, several genetic variants were identified as monogenic forms of human obesity having success over common polygenic forms. In the context of molecular genetics, genome-wide association studies (GWAS) approach and their findings signified a number of genetic variants predisposing to obesity. However, the last couple of years, it has also been noticed that alterations in the environmental and epigenetic factors are one of the key causes of obesity. Hence, this review might be helpful in the current scenario of molecular genetics of human obesity, obesity-related health complications (ORHC), and energy homeostasis. Future work based on the clinical discoveries may play a role in the molecular dissection of genetic approaches to find more obesity-susceptible gene loci.
authors.affiliation: Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, 632014 Vellore, India.
authors.forename: Rajan Kumar
authors.initials: RK
authors.lastname: Singh
authors.affiliation: Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, 632014 Vellore, India.
authors.forename: Permendra
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, 632014 Vellore, India. Electronic address: kmahalingam@vit.ac.in.
authors.forename: Kulandaivelu
authors.initials: K
authors.lastname: Mahalingam
mesh_terms: D004734:Energy Metabolism / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005826:Genetics, Medical; D055106:Genome-Wide Association Study; D006801:Humans; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000378:metabolism
keywords: Energy homeostasis; Epigenetics; GWAS; ORHC; Obesity