title: Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium.
abstract: Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O2·-) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.
authors.affiliation: a Department for Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
authors.forename: Aida
authors.initials: A
authors.lastname: Begic
authors.affiliation: a Department for Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Djuric
authors.affiliation: b Institute for Medical Research, Military Medical Academy , Belgrade , Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Ninkovic
authors.affiliation: b Institute for Medical Research, Military Medical Academy , Belgrade , Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Stevanovic
authors.affiliation: b Institute for Medical Research, Military Medical Academy , Belgrade , Serbia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Djurdjevic
authors.affiliation: c Department for Reproduction, Fertility and Artificial Insemination, Faculty of Veterinarian Medicine , University of Belgrade , Belgrade , Serbia.
authors.forename: Milos
authors.initials: M
authors.lastname: Pavlovic
authors.affiliation: d Department for Pathology and Forensic Medicine , Military Medical Academy , Belgrade , Serbia.
authors.forename: Katarina
authors.initials: K
authors.lastname: Jelic
authors.affiliation: e Department for Applied Chemistry, Faculty of Chemistry , University of Belgrade , Belgrade , Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Pantelic
authors.affiliation: f Department for Food Technology, Faculty of Agriculture , University of Belgrade , Belgrade , Serbia.
authors.forename: Goran
authors.initials: G
authors.lastname: Zebic
authors.affiliation: g Military Medical Center Karaburma , Belgrade , Serbia.
authors.forename: Bratislav
authors.initials: B
authors.lastname: Dejanovic
authors.affiliation: b Institute for Medical Research, Military Medical Academy , Belgrade , Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Stanojevic
authors.affiliation: b Institute for Medical Research, Military Medical Academy , Belgrade , Serbia.
authors.forename: Danilo
authors.initials: D
authors.lastname: Vojvodic
authors.affiliation: b Institute for Medical Research, Military Medical Academy , Belgrade , Serbia.
authors.forename: Petar
authors.initials: P
authors.lastname: Milosavljevic
authors.affiliation: a Department for Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy , University of Belgrade , Belgrade , Serbia.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Djukic
authors.affiliation: h Department of Physiology and Pharmacology, Sapienza University , Rome , Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Saso
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004221:Disulfiram / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002104:Cadmium; D004221:Disulfiram
keywords: Cadmium; disulfiram; essential metals; hepatotoxicity; oxidative stress