title: Medication Adherence in Hematopoietic Stem Cell Transplantation: A Review of the Literature.
abstract: Adherence to oral medications has been repeatedly shown to fall below the recommended 80% to 95% in pediatric and adult cancer populations. The purpose of this review is to report the state of the science about oral medication adherence during the acute phase of hematopoietic stem cell transplantation across the lifespan. An exhaustive search of the literature yielded 5 records for inclusion in the review. Two studies examined adherence in pediatrics, 2 in adults, and 1 included both pediatric and adult patients. Three studies were descriptive and 2 were interventional in design. The rate of adherence to oral medications ranged from 33% to 94.7%. Adherence decreased over time in all studies except in 1 pharmacist-led intervention study. Different methods were used to measure adherence, but most relied on self-report. Further research is needed in medication adherence in hematopoietic stem cell transplantation to better understand facilitators, barriers, and relationships to health outcomes.
authors.affiliation: Center for the Promotion of Adherence and Self-Management, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address: caroline.morrison@cchmc.org.
authors.forename: Caroline F
authors.initials: CF
authors.lastname: Morrison
authors.affiliation: College of Nursing, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Donna M
authors.initials: DM
authors.lastname: Martsolf
authors.affiliation: College of Nursing, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Nicole
authors.initials: N
authors.lastname: Wehrkamp
authors.affiliation: College of Nursing, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Tehan
authors.affiliation: Center for the Promotion of Adherence and Self-Management, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Patient and Family Wellness Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio.
authors.forename: Ahna L H
authors.initials: ALH
authors.lastname: Pai
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D010595:Pharmacists; D055815:Young Adult; D016903:Drug Monitoring
keywords: Acute phase; Adherence; Hematopoietic stem cell transplantation; Medication; Treatment