title: Convergence of interoception, emotion, and social cognition: A twofold fMRI meta-analysis and lesion approach.
abstract: Guided by indirect evidence, recent approaches propose a tripartite crosstalk among interoceptive signaling, emotional regulation, and low-level social cognition. Here we examined the neurocognitive convergence of such domains. First, we performed three meta-analyses of functional magnetic resonance imaging studies to identify which areas are consistently coactivated by these three systems. Multi-level Kernel Density Analysis (MKDA) revealed major overlaps in the right anterior insular and frontotemporal regions (viz., the orbitofrontal and inferior frontal gyri, the amygdala, and mid temporal lobe/subcortical structures). Second, we explored such domains in patients with fronto-insulo-temporal damage. Relative to controls, the patients showed behavioral impairments of interoception, emotional processing, and social cognition, with preservation of other cognitive functions. Convergent results from both studies offer direct support for a model of insular-frontotemporal regions integrating interoception, emotion, and social cognition.
authors.affiliation: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; Facultad de Artes y Ciencias Musicales (FAyCM), Universidad Católica Argentina (UCA), Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
authors.forename: Federico
authors.initials: F
authors.lastname: Adolfi
authors.affiliation: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
authors.forename: Blas
authors.initials: B
authors.lastname: Couto
authors.affiliation: Universität zu Köln, Department of Psychology, Cologne, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Richter
authors.affiliation: University of Chicago, Department of Psychology, Chicago, IL, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Decety
authors.affiliation: Universidad Santiago de Cali, Facultad de Salud, Cali, Colombia.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lopez
authors.affiliation: Universidad Torcuato DiTella, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
authors.forename: Mariano
authors.initials: M
authors.lastname: Sigman
authors.affiliation: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina; Centre of Excellence in Cognition and its Disorders, Australian Research Council (ACR), Sydney, Australia.
authors.forename: Facundo
authors.initials: F
authors.lastname: Manes
authors.affiliation: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina; Universidad Autónoma del Caribe, Barranquilla, Colombia; Centre of Excellence in Cognition and its Disorders, Australian Research Council (ACR), Sydney, Australia; Laboratory of Neuroscience, School of Psychology, Universidad Adolfo Ibañez, Santiago de Chile, Chile. Electronic address: aibanez@ineco.org.ar.
authors.forename: Agustín
authors.initials: A
authors.lastname: Ibáñez
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology; D004644:Emotions / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D065812:Interoception / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012938:Social Perception
keywords: Frontotemporal networks; Insula; Multi-level Kernel Density Analysis; Stroke