title: Relationship between HLA haplotype and BMI change in Japanese slowly progressive type 1 diabetes patients.
abstract: We investigated the association between susceptible HLA and BMI change rate from diagnosis of diabetes to diagnosis of slowly progressive type 1 diabetes in Japanese diabetic patients. Subjects with the HLA DRB1*04:05-DQB1*04:01 haplotype were more likely to show weight loss than those without. This HLA haplotype might affect weight loss.
authors.affiliation: Diabetes Center, Tokyo Women's Medical University School of Medicine, Japan.
authors.forename: Sari
authors.initials: S
authors.lastname: Hoshina
authors.affiliation: Diabetes Center, Tokyo Women's Medical University School of Medicine, Japan. Electronic address: jmiura.dmc@twmu.ac.jp.
authors.forename: Junnosuke
authors.initials: J
authors.lastname: Miura
authors.affiliation: Diabetes Center, Tokyo Women's Medical University School of Medicine, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Uchigata
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D015431:Weight Loss / Q000235:genetics
chemical_list: D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains
keywords: BMI; GAD autoantibody; HLA; Slowly progressive type 1 (insulin-dependent) diabetes mellitus (SPIDDM)