title: Mechanochemically synthesized Ag-based nanohybrids with unprecedented low toxicity in biomedical applications.
abstract: A simple and innovative mechanochemical approach was employed to synthesize Ag-polysaccharide nanohybrid materials that were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized Ag nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SY5Y as compared to similarly reported Ag nanomaterials due to the stability and low release of Ag+and high biocompatibility of the nanohybrids.
authors.affiliation: Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Edificio Marie Curie, E-14014 Cordoba, Spain.
authors.forename: Rick A D
authors.initials: RAD
authors.lastname: Arancon
authors.affiliation: Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Edificio Marie Curie, E-14014 Cordoba, Spain.
authors.forename: Alina M
authors.initials: AM
authors.lastname: Balu
authors.affiliation: Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Edificio Marie Curie, E-14014 Cordoba, Spain.
authors.forename: Antonio A
authors.initials: AA
authors.lastname: Romero
authors.affiliation: Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Edificio Marie Curie, E-14014 Cordoba, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ojeda
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain. Electronic address: mariamercedes.gomez@urv.cat.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Gomez
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Blanco
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Domingo
authors.affiliation: Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Edificio Marie Curie, E-14014 Cordoba, Spain. Electronic address: q62alsor@uco.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Luque
mesh_terms: D000072283:A549 Cells; D001697:Biomedical and Dental Materials / Q000627:therapeutic use* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D003603:Cytotoxins / Q000627:therapeutic use* / Q000633:toxicity*; D006801:Humans; D049329:Nanostructures / Q000627:therapeutic use* / Q000633:toxicity*; D012834:Silver / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity*; D013499:Surface Properties; D018675:Toxicity Tests
chemical_list: D001697:Biomedical and Dental Materials; D003603:Cytotoxins; D012834:Silver
keywords: Ag nanoparticles; Biomaterials; Cytotoxicity; Mechanochemistry; Nanocomposites; Polysaccharides