title: Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives.
abstract: Molecularly imprinted polymers (MIPs) are biomimetics which can selectively bind to analytes of interest. One of the most interesting areas where MIPs have shown the biggest potential is food analysis. MIPs have found use as sorbents in sample preparation attributed to the high selectivity and high loading capacity. MIPs have been intensively employed in classical solid-phase extraction and solid-phase microextraction. More recently, MIPs have been combined with magnetic bead extraction, which greatly simplifies sample handling procedures. Studies have consistently shown that MIPs can effectively minimize complex food matrix effects, and improve recoveries and detection limits. In addition to sample preparation, MIPs have also been viewed as promising alternatives to bio-receptors due to the inherent molecular recognition abilities and the high stability in harsh chemical and physical conditions. MIPs have been utilized as receptors in biosensing platforms such as electrochemical, optical and mass biosensors to detect various analytes in food. In this review, we will discuss the current state-of-the-art of MIP synthesis and applications in the context of food analysis. We will highlight the imprinting methods which are applicable for imprinting food templates, summarize the recent progress in using MIPs for preparing and analysing food samples, and discuss the current limitations in the commercialisation of MIPs technology. Finally, future perspectives will be given.
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: Jon
authors.initials: J
authors.lastname: Ashley
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: Mohammad-Ali
authors.initials: MA
authors.lastname: Shahbazi
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: Krishna
authors.initials: K
authors.lastname: Kant
authors.affiliation: Laboratory of Applied Micro and Nanotechnology (LAMINATE), National Food Institute, Technical University of Denmark (DTU-Food), Denmark.
authors.forename: Vinayaka Aaydha
authors.initials: VA
authors.lastname: Chidambara
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, DK-2800 Kgs, Lyngby, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Wolff
authors.affiliation: Laboratory of Applied Micro and Nanotechnology (LAMINATE), National Food Institute, Technical University of Denmark (DTU-Food), Denmark.
authors.forename: Dang Duong
authors.initials: DD
authors.lastname: Bang
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, DK-2800 Kgs, Lyngby, Denmark. Electronic address: sun.yi@nanotech.dtu.dk.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D005504:Food Analysis / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D054802:Molecular Imprinting / Q000295:instrumentation / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods
chemical_list: D011108:Polymers
keywords: Biosensors; Food analysis; Molecularly imprinted polymers; Sample preparation