title: Does Body Mass Index Predict Premature Cardiomyopathy Onset for Duchenne Muscular Dystrophy?
abstract: Duchenne muscular dystrophy leads to cardiomyopathy. The objective of this study was to estimate the association of body mass index with cardiomyopathy onset. Cardiomyopathy was defined as left ventricular ejection fraction <55% or left ventricular fractional shortening <28%. Overall, 48% met the criteria for cardiomyopathy. We were unable to demonstrate an association between body mass index Z score and age of cardiomyopathy onset (hazard ratio 0.79, 95% confidence interval 0.57-1.11, P = .17) after adjusting for covariates. Duration of corticosteroid use ( P = .01), but not loss of ambulatory ability ( P = .47), was associated with age of cardiomyopathy onset. We were unable to detect a significant difference in median body mass index Z scores in corticosteroid-treated boys compared with corticosteroid-naïve boys (1.11, 95% confidence interval 0.25-1.95, vs 1.05, 95% confidence interval 0.01-1.86, P = .69). No association was detected between the body mass index Z scores of Duchenne muscular dystrophy subjects and age of cardiomyopathy onset.
authors.affiliation: 1 Thomas P. Graham Division of Pediatric Cardiology Monroe Carell Jr Children's Hospital at Vanderbilt University, Nashville, TN, USA.
authors.forename: Meghann
authors.initials: M
authors.lastname: McKane
authors.affiliation: 1 Thomas P. Graham Division of Pediatric Cardiology Monroe Carell Jr Children's Hospital at Vanderbilt University, Nashville, TN, USA.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Soslow
authors.affiliation: 2 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.affiliation: 2 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Saville
authors.affiliation: 2 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Slaughter
authors.affiliation: 3 Division of Neurology, Department of Pediatrics, Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, TN, USA.
authors.forename: W Bryan
authors.initials: WB
authors.lastname: Burnette
authors.affiliation: 1 Thomas P. Graham Division of Pediatric Cardiology Monroe Carell Jr Children's Hospital at Vanderbilt University, Nashville, TN, USA.
authors.forename: Larry W
authors.initials: LW
authors.lastname: Markham
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015992:Body Mass Index; D009202:Cardiomyopathies / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000150:complications* / Q000503:physiopathology; D011379:Prognosis; D055815:Young Adult
keywords: Duchenne muscular dystrophy; body mass index; cardiomyopathy