title: Production of water-soluble yellow pigments via high glucose stress fermentation of Monascus ruber CGMCC 10910.
abstract: Monascus pigments are secondary metabolites of Monascus species and are mainly composed of yellow pigments, orange pigments and red pigments. In this study, a larger proportion of Monascus yellow pigments could be obtained through the selection of the carbon source. Hydrophilic yellow pigments can be largely produced extracellularly by Monascus ruber CGMCC 10910 under conditions of high glucose fermentation with low oxidoreduction potential (ORP). However, keeping high glucose levels later in the culture causes translation or a reduction of yellow pigment. We presume that the mechanism behind this phenomenon may be attributed to the redox level of the culture broth and the high glucose stress reaction of M. ruber CGMCC 10910 during high glucose fermentation. These yellow pigments were produced via high glucose bio-fermentation without citrinin. Therefore, these pigments can act as natural pigments for applications as food additives.
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, People's Republic of China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, People's Republic of China.|Dongguan Tianyi Biotech. Co. Ltd., Dongguan, 523000, China.
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, People's Republic of China. btzhqwu@scut.edu.cn.
authors.forename: Zhenqiang
authors.initials: Z
authors.lastname: Wu
mesh_terms: D002244:Carbon / Q000378:metabolism; D005285:Fermentation; D005503:Food Additives / Q000737:chemistry; D005947:Glucose / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D032741:Monascus / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D010860:Pigments, Biological / Q000096:biosynthesis* / Q000737:chemistry*; D012995:Solubility; D013312:Stress, Physiological; D014867:Water / Q000737:chemistry*
chemical_list: D005503:Food Additives; D010860:Pigments, Biological; D014867:Water; D002244:Carbon; D005947:Glucose
keywords: High glucose stress; Monascus ruber; ORP; Water-soluble yellow pigment