title: Use of antipsychotics, benzodiazepine derivatives, and dementia medication among older people with intellectual disability and/or autism spectrum disorder and dementia.
abstract: BACKGROUND
  Although people with intellectual disability (ID) and people with dementia have high drug prescription rates, there is a lack of studies investigating drug use among those with concurrent diagnoses of ID and dementia.
  
  
  OBJECTIVE
  To investigate the use of antipsychotics, benzodiazepine derivatives, and drugs recommended for dementia treatment (anticholinesterases [AChEIs] and memantine) among people with ID and dementia.
  
  
  METHODS
  Having received support available for people with ID and/or autism spectrum disorder (ASD) was used as a proxy for ID. The ID cohort consisted of 7936 individuals, aged at least 55 years in 2012, and the referent cohort of age- and sex-matched people from the general population (gPop). People with a specialists' diagnosis of dementia during 2002-2012 were identified (ID, n=180; gPop, n=67), and data on prescription of the investigated drugs during the period 2006-2012 were collected.
  
  
  RESULTS
  People with ID/ASD and dementia were more likely than people with ID/ASD but without dementia to be prescribed antipsychotics (50% vs 39% over the study period; odds ratio (OR) 1.85, 95% confidence interval 1.13-30.3) and benzodiazepine derivatives (55% vs 36%; OR 2.42, 1.48-3.98). They were also more likely than people with dementia from the general population to be prescribed antipsychotics (50% vs 25%; OR 3.18, 1.59-6.34), but less likely to be prescribed AChEIs (28% vs 45%; OR 0.32, 0.16-0.64).
authors.affiliation: Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, SE 221 00 Lund, Sweden. Electronic address: anna.axmon@med.lu.se.
authors.forename: Anna
authors.initials: A
authors.lastname: Axmon
authors.affiliation: Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden. Electronic address: jimmie.kristensson@med.lu.se.
authors.forename: Jimmie
authors.initials: J
authors.lastname: Kristensson
authors.affiliation: Department of Health Sciences, Lund University, SE 221 00 Lund, Sweden. Electronic address: gerd.ahlstrom@med.lu.se.
authors.forename: Gerd
authors.initials: G
authors.lastname: Ahlström
authors.affiliation: Center for Primary Health Care Research, Department of Clinical Sciences in Malmö, Lund University, SE 221 00 Lund, Sweden. Electronic address: patrik.midlov@med.lu.se.
authors.forename: Patrik
authors.initials: P
authors.lastname: Midlöv
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000067877:Autism Spectrum Disorder / Q000188:drug therapy* / Q000523:psychology; D001569:Benzodiazepines / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D015331:Cohort Studies; D003704:Dementia / Q000188:drug therapy* / Q000523:psychology; D015259:Dopamine Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008559:Memantine / Q000627:therapeutic use; D008875:Middle Aged; D016017:Odds Ratio; D000066553:Problem Behavior / Q000523:psychology; D012042:Registries; D013548:Sweden
chemical_list: D014150:Antipsychotic Agents; D002800:Cholinesterase Inhibitors; D015259:Dopamine Agents; D001569:Benzodiazepines; D008559:Memantine
keywords: Anticholinesterases; Drug prescription; Drug use; Memantine; Registry study; Sweden