title: NKG2D Signaling: The Immune Subversive Side of HDAC3.
abstract: Natural killer (NK) cells are alerted to infected and transformed cells by local upregulation of ligands for the NK-activating receptor NKG2D. In a recent report, Greene et al. unveil a new mechanism that induces the expression of the NKG2D ligand retinoic acid early-inducible (RAE-1) in response to murine cytomegalovirus (MCMV) infection through inhibition of casein kinase 2 (CK2), an activator of the repressor histone deacetylase HDAC3.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
authors.forename: Alicia R
authors.initials: AR
authors.lastname: Folgueras
authors.affiliation: Departamento de Biología Funcional, Inmunología, Facultad de Medicina, IUOPA, Universidad de Oviedo, 33006 Oviedo, Spain.
authors.forename: Segundo
authors.initials: S
authors.lastname: Gonzalez
authors.affiliation: Departamento de Biología Funcional, Inmunología, Facultad de Medicina, IUOPA, Universidad de Oviedo, 33006 Oviedo, Spain; Hospital Universitario Central de Asturias (HUCA), Fundación para la Investigación e Innovación Biosanitaria en el Principado de Asturias (FINBA), 33006 Oviedo, Spain. Electronic address: lopezsalejandro@uniovi.es.
authors.forename: Alejandro
authors.initials: A
authors.lastname: López-Soto
mesh_terms: D000818:Animals; D047390:Casein Kinase II / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D044127:Epigenesis, Genetic; D057809:HEK293 Cells; D006566:Herpesviridae Infections / Q000276:immunology*; D006655:Histone Deacetylases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018146:Muromegalovirus / Q000276:immunology*; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D051705:Sp3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D000099186:Histone Deacetylase 3
chemical_list: D047390:Casein Kinase II; D006655:Histone Deacetylases; D008565:Membrane Proteins; D055655:NK Cell Lectin-Like Receptor Subfamily K; D051705:Sp3 Transcription Factor; D000099186:Histone Deacetylase 3; C584972:Raet1e protein, mouse