title: Autogenous bone particle/titanium fiber composites for bone regeneration in a rabbit radius critical-size defect model.
abstract: OBJECTIVE
  To explore the effects of autogenous bone particle/titanium fiber composites on repairing segmental bone defects in rabbits.
  
  
  METHODS
  A model of bilateral radial bone defect was established in 36 New Zealand white rabbits which were randomly divided into 3 groups according to filling materials used for bilaterally defect treatment: in group C, 9 animal bone defect areas were prepared into simple bilateral radius bone defect (empty sham) as the control group; 27 rabbits were used in groups ABP and ABP-Ti. In group ABP, left defects were simply implanted with autogenous bone particles; meanwhile, group ABP-Ti animals had right defects implanted with autogenous bone particle/titanium fiber composites. Animals were sacrificed at 4, 8, and 12 weeks, respectively, after operation.
  
  
  RESULTS
  Micro-CT showed that group C could not complete bone regeneration. Bone volume to tissue volume values in group ABP-Ti were better than group ABP. From histology and histomorphometry Groups ABP and ABP-Ti achieved bone repair, the bone formation of group ABP-Ti was better. The mechanical strength of group ABP-Ti was superior to that of other groups.
  
  
  CONCLUSIONS
  These results confirmed the effectiveness of autologous bone particle/titanium fiber composites for promoting bone regeneration and mechanical strength.
authors.affiliation: a Department of Orthopaedic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Xie
authors.affiliation: a Department of Orthopaedic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ji
authors.affiliation: b Department of Stomatology, Zhaochunyu Dental Clinic , Harbin , China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Tian
authors.affiliation: a Department of Orthopaedic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Xintao
authors.initials: X
authors.lastname: Wang
authors.affiliation: c Department of Orthopaedic Surgery, the Second Affiliated Hospital of Qiqihar Medical College , Qiqihar , China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: d Department of Orthopaedic Surgery, Harbin the First Hospital , Harbin , China.
authors.forename: Yicai
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Department of Orthopaedic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: a Department of Orthopaedic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Nanxiang
authors.initials: N
authors.lastname: Wang
authors.affiliation: a Department of Orthopaedic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Jinglong
authors.initials: J
authors.lastname: Yan
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000378:metabolism; D016025:Bone Transplantation / Q000379:methods; D008297:Male; D010012:Osteogenesis / Q000502:physiology*; D011884:Radius / Q000166:cytology*; D017207:Rats, Sprague-Dawley; D054457:Tissue Scaffolds; D014025:Titanium / Q000378:metabolism*
chemical_list: D018786:Bone Substitutes; C101914:titanium fiber; D014025:Titanium
keywords: Autogenous bone particles; bone regeneration; fiber reinforcement; titanium fiber