title: A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years.
abstract: Autologous Matrix-Induced Chondrogenesis (AMIC®) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years.
  
  
  
  Forty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm2) were randomized and treated either with MFx, with sutured or glued AMIC®in a prospective multicentre clinical trial.
  
  
  
  After improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC®groups. At two and five years, MRI defect filling was more complete in the AMIC®groups. No treatment-related adverse events were reported.
  
  
  
  AMIC®is an effective cartilage repair procedure in the knee resulting in stable clinical results significantly better than the MFx group at five years.
authors.affiliation: Sportklinik Ravensburg, Ravensburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Volz
authors.affiliation: Department of Orthopedic Surgery, University of Regensburg, Asklepios Clinical Center Bad Abbach, Bad Abbach, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Schaumburger
authors.affiliation: Sportklinik Ravensburg, Ravensburg, Germany.
authors.forename: Hubert
authors.initials: H
authors.lastname: Frick
authors.affiliation: Department of Orthopedic Surgery, University of Regensburg, Asklepios Clinical Center Bad Abbach, Bad Abbach, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Grifka
authors.affiliation: Department of Orthopedic Surgery, University of Regensburg, Asklepios Clinical Center Bad Abbach, Bad Abbach, Germany. s.anders@asklepios.com.
authors.forename: Sven
authors.initials: S
authors.lastname: Anders
mesh_terms: D000328:Adult; D054544:Arthroplasty, Subchondral / Q000534:rehabilitation; D002357:Cartilage Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000601:surgery*; D020219:Chondrogenesis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000601:surgery*; D011446:Prospective Studies; D014182:Transplantation, Autologous / Q000534:rehabilitation; D016896:Treatment Outcome; D055815:Young Adult
keywords: Articular cartilage; Autologous Matrix-Induced Chondrogenesis (AMIC®); Chondro-Gide®; Knee surgery; Microfracture