title: How Presentation of Drug Detection Results Changed Reports of Product Adherence in South Africa, Uganda and Zimbabwe.
abstract: Accurate estimates of study product use are critical to understanding and addressing adherence challenges in HIV prevention trials. The VOICE trial exposed a significant gap between self-reported adherence and drug detection. The VOICE-D qualitative study was designed to better understand non-adherence during VOICE, and was conducted in 2 stages: before (stage 1) and after (stage 2) drug detection results were provided to participants. Transcripts from 44 women who participated in both stages were analysed to understand the effect of presenting drug detection data on narratives of product use. Thirty-six women reported high adherence in stage 1, yet admitted non-use in stage 2, three reported high adherence in both stages (contrary to their drug detection results) and five had consistent responses across both stages and drug results. Presenting objective measures of use may facilitate more accurate product use reporting and should be evaluated in future prevention trials.
authors.affiliation: University of Zimbabwe-University of California San Francisco Collaborative Research Programme, 15 Phillips, Belgravia, Harare, Zimbabwe. petina@uz-ucsf.co.zw.
authors.forename: Petina
authors.identifier: 0000-0001-9668-4344
authors.initials: P
authors.lastname: Musara
authors.affiliation: Women's Global Health Imperative; RTI International, San Francisco, CA, USA.
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Montgomery
authors.affiliation: University of Zimbabwe-University of California San Francisco Collaborative Research Programme, 15 Phillips, Belgravia, Harare, Zimbabwe.
authors.forename: Nyaradzo M
authors.initials: NM
authors.lastname: Mgodi
authors.affiliation: HIV Prevention Research Unit, South African Medical Research Council, Cape Town, South Africa.
authors.forename: Kubashni
authors.initials: K
authors.lastname: Woeber
authors.affiliation: Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
authors.forename: Carolyne A
authors.initials: CA
authors.lastname: Akello
authors.affiliation: Women's Global Health Imperative; RTI International, San Francisco, CA, USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Hartmann
authors.affiliation: Women's Global Health Imperative; RTI International, San Francisco, CA, USA.
authors.forename: Helen
authors.initials: H
authors.lastname: Cheng
authors.affiliation: FHI-360, Durham, NC, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Levy
authors.affiliation: Women's Global Health Imperative; RTI International, San Francisco, CA, USA.
authors.forename: Ariana
authors.initials: A
authors.lastname: Katz
authors.affiliation: DAIDS/NIH/NIMH, Bethesda, MD, USA.
authors.forename: Cynthia I
authors.initials: CI
authors.lastname: Grossman
authors.affiliation: University of Zimbabwe-University of California San Francisco Collaborative Research Programme, 15 Phillips, Belgravia, Harare, Zimbabwe.
authors.forename: Z Mike
authors.initials: ZM
authors.lastname: Chirenje
authors.affiliation: Women's Global Health Imperative; RTI International, San Francisco, CA, USA.|Center for AIDS Prevention Studies, UCSF, San Francisco, CA, USA.
authors.forename: Ariane
authors.initials: A
authors.lastname: van der Straten
authors.affiliation: Population Council, New York, NY, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Mensch
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D006801:Humans; D055118:Medication Adherence; D065129:Pre-Exposure Prophylaxis; D036301:Qualitative Research; D057566:Self Report; D013019:South Africa / Q000453:epidemiology; D014454:Uganda / Q000453:epidemiology; D015030:Zimbabwe / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents
keywords: Adherence measures; Drug detection results; HIV prevention; Microbicides; Pre-exposure prophylaxis