title: Magnetic Resonance Volumetry: Prediction of Subjective Memory Complaints and Mild Cognitive Impairment, and Associations with Genetic and Cardiovascular Risk Factors.
abstract: OBJECTIVE
  Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzheimer's disease. Our aims were to see if fully automated cerebral MR volume measurements could distinguish subjects with SMC and MCI from controls, and if probable parental late-onset Alzheimer's disease (LOAD), apolipoprotein E ε4 genotype, total plasma homocysteine, and cardiovascular risk factors were associated with MR volumetric findings.
  
  
  METHODS
  198 stroke-free subjects comprised the control (n = 58), the SMC (n = 25) and the MCI (n = 115) groups. Analysis of covariance and receiver operating characteristic curve was used to see if MR volumetry distinguished subjects with SMC and MCI from controls.
  
  
  RESULTS
  Subjects with SMC and MCI had significantly larger lateral ventricles and smaller hippocampal volumes than controls. The area under the curve in subjects with SMC and MCI compared to that of controls was less than 0.68 for all volumes of intracranial structures. There was an interaction between sex and probable parental LOAD for hippocampal volume, with a significant association between probable parental LOAD and hippocampal volume in women.
  
  
  CONCLUSIONS
  Fully automated MR volumetry can distinguish subjects with SMC and MCI from controls in a general population, but insufficiently to assume a clear clinical role. Research on sporadic LOAD might benefit from a sex-specific search for genetic risk factors.
authors.affiliation: Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
authors.forename: Sigbjørn
authors.initials: S
authors.lastname: Rogne
authors.affiliation: Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway; Department of Radiology, University Hospital of North Norway, Tromsø, Norway.
authors.forename: Torgil
authors.initials: T
authors.lastname: Vangberg
authors.affiliation: Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway; Department of Radiology, University Hospital of North Norway, Tromsø, Norway.
authors.forename: Petter
authors.initials: P
authors.lastname: Eldevik
authors.affiliation: Department of Radiology, University Hospital of North Norway, Tromsø, Norway.
authors.forename: Gry
authors.initials: G
authors.lastname: Wikran
authors.affiliation: Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway; Department of Neurology and Neurophysiology, University Hospital of North Norway, Tromsø, Norway.
authors.forename: Ellisiv B
authors.initials: EB
authors.lastname: Mathiesen
authors.affiliation: Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway; Department of Cardiology, Division of Cardiothoracic and Respiratory Disease, University Hospital of North Norway, Tromsø, Norway.
authors.forename: Henrik
authors.initials: H
authors.lastname: Schirmer
keywords: Alzheimer's disease; Apolipoprotein E4; Cardiovascular risk factors; Family history; Gender; Homocysteine; Magnetic resonance imaging; Mild cognitive impairment; Subjective memory complaints