title: Synthesis and Reactivity of18F-Labeled α,α-Difluoro-α-(aryloxy)acetic Acids.
abstract: In this work, we describe the18F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-18F-fluorination functionalization. Protodecarboxylation offers a new entry to18F-difluoromethoxyarene, and the value of this approach is further demonstrated with coupling processes leading to representative18F-labeled TRPV1 inhibitors and TRPV1 antagonists.
authors.affiliation: Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Tanatorn
authors.initials: T
authors.lastname: Khotavivattana
authors.affiliation: Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Samuel
authors.initials: S
authors.lastname: Calderwood
authors.affiliation: Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Stefan
authors.initials: S
authors.lastname: Verhoog
authors.affiliation: Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Lukas
authors.initials: L
authors.lastname: Pfeifer
authors.affiliation: Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Sean
authors.initials: S
authors.lastname: Preshlock
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital , 55 Fruit Street, Boston 02114, United States.|Department of Radiology, Harvard Medical School , 55 Fruit Street, Boston 02114, United States.
authors.forename: Neil
authors.initials: N
authors.lastname: Vasdev
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital , 55 Fruit Street, Boston 02114, United States.|Department of Radiology, Harvard Medical School , 55 Fruit Street, Boston 02114, United States.|Advion BioSystems, 10 Brown Road, Suite 101, Ithaca, New York 14850, United States.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Collier
authors.affiliation: Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Véronique
authors.identifier: 0000-0001-8638-5308
authors.initials: V
authors.lastname: Gouverneur