title: Oxytocin for frontotemporal dementia: a systematic review.
abstract: BACKGROUND
  The aim of this systematic review is to identify published randomized controlled trials (RCTs) that evaluated the use of oxytocin in individuals with frontotemporal dementia (FTD).
  
  
  METHODS
  A literature search was conducted of PubMed, MEDLINE, EMBASE, PsycINFO and Cochrane collaboration databases for RCTs in any language that evaluated the use of oxytocin in individuals with FTD. Bibliographic databases of published articles were also searched for additional studies.
  
  
  RESULTS
  A total of two RCTs that evaluated the use of oxytocin in individuals with FTD were identified. In one study, the use of oxytocin in individuals with FTD produced a reduction in identification of negative facial expressions (anger and fear) which can be hypothesized to improve trust and increase cooperation in these individuals. Both studies noted oxytocin was well tolerated and showed short term benefits on behavioral symptoms in individuals with FTD.
  
  
  CONCLUSIONS
  Oxytocin appears to improve social aspects of cognition and behavioral symptoms in individuals with FTD and is well tolerated. However, positive data from larger and longer duration RCTs are needed before the routine use of oxytocin in individuals with FTD can be recommended.
authors.affiliation: Vice Chairman for Education and Program Director, Department of Psychiatry, MetroHealth, 2500 MetroHealth Drive, Cleveland, Ohio, 44109, USA.
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Tampi
authors.affiliation: Department of Psychiatry, MetroHealth, Cleveland, Ohio, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Maksimowski
authors.affiliation: Department of Psychiatry, MetroHealth, Cleveland, Ohio, USA.
authors.forename: Mohsina
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Saint Francis Hospital and Medical Center, Hartford, Connecticut, USA.
authors.forename: Deena J
authors.initials: DJ
authors.lastname: Tampi
keywords: frontotemporal dementia; oxytocin; randomized controlled trials; systematic review