title: Association of Dietary Patterns With Global and Domain-Specific Cognitive Decline in Chinese Elderly.
abstract: BACKGROUND
  Significant differences exist between eastern and western diets, and the way in which Chinese dietary intake relates to specific cognitive domains remains unclear. We aimed to assess the association between dietary patterns (DPs) and cognitive decline in Chinese elderly.
  
  
  METHODS
  Participants were recruited from the elderly health checkup program of a teaching hospital in Taipei, Taiwan.
  
  
  METHODS
  A total of 475 elders (age ≥65) were included in this prospective cohort study.
  
  
  METHODS
  The outcome comprised the decline of global and domain-specific cognition between baseline (2011-2013) and follow-up (2013-2015). Dietary data from the previous year were collected via a food frequency questionnaire at baseline, and a factor analysis was performed to identify DPs. Multivariable linear regression and logistic regression models were used to assess associations between Chinese DPs and cognitive decline over 2 years adjusting for selected covariates.
  
  
  RESULTS
  Three DPs (vegetable, meat, and traditional) were identified. Moderate- or high-score "vegetable" DP significantly protected against decline of logical memory (recall I: β = 0.16-0.18, odds ratio (OR) = 0.42-0.48; recall II: β = 0.17-0.21); while high-score DP increased executive function decline (β = -0.22). A high-score "meat" DP was related to decline of verbal fluency-total score (β = -0.19); while moderate- or high-score "meat" DP protected against attention decline (β = 0.20-0.22). High-score "traditional" DP protected against decline of logical memory-recall I (β = 0.18). No significant association was observed for global cognition.
  
  
  CONCLUSIONS
  These findings suggest that three DPs identified in Chinese elderly were associated with different cognitive domains. Further research is needed to explore the efficacy of dietary interventions in reducing cognitive decline in older adults.
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.|Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.|Research Center for Genes, Environment, and Human Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Yen-Ching
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Chien-Cheng
authors.initials: CC
authors.lastname: Jung
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.|Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Jen-Hau
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
authors.forename: Jeng-Min
authors.initials: JM
authors.lastname: Chiou
authors.affiliation: Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Ta-Fu
authors.initials: TF
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Ya-Fang
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Sung-Chun
authors.initials: SC
authors.lastname: Tang
authors.affiliation: Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Shin-Joe
authors.initials: SJ
authors.lastname: Yeh
authors.affiliation: Department of Public Health, School of Public Health, National Defense Medical College, Taipei, Taiwan.
authors.forename: Meei-Shyuan
authors.initials: MS
authors.lastname: Lee
mesh_terms: D044466:Asian People; D003071:Cognition; D003072:Cognition Disorders; D004032:Diet / Q000706:statistics & numerical data*; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013624:Taiwan
keywords: cognitive decline; dietary pattern; elderly