title: In vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L.
abstract: Diospyros lotus L. possesses different therapeutic activities such as antioxidant, anti-proliferative, anti-microbial and sedative. However, no studies on the sedative-hypnotic activity of 7-methyljuglone are reported. In the present study, we have evaluated in vivo the anxiolytic-hypnotic like effects of 7-methyljuglone in mice with open field and phenobarbitone-induced sleeping time tests. We have also assessed in silico the involvement of GABAA, GABABand 5HT1 neurotransmission in its mechanism of action. The intraperitoneal administration of 7-methyljuglone (2.5-10mg/kg) reduce significantly the number of crossed lines in mice open field test and concomitantly it shown a significant activity in term of onset of sleeping time and also in its duration. Moreover, 7-methyljuglone demonstrated in silico an interesting interaction with GABAAbut not GABABand 5HT1binding sites. All of these results, taken together, 7-methyljuglone may be an innovative candidate for designing new pharmaceutical and therapeutic applications.
authors.affiliation: Department of Chemistry, University of Swabi, Swabi, Anbar, 23561 Khyber Pakhtunkhwa, Pakistan. Electronic address: mashaljcs@yahoo.com.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.affiliation: Deparment of Biology, University of Selcuk, Konya, Turkey.
authors.forename: Sengul
authors.initials: S
authors.lastname: Uysal
authors.affiliation: LCMS laboratory, Univesity of Mohamed 1st, Faculty of Sciences, Oujda 60000, Morocco.
authors.forename: Taibi Ben
authors.initials: TB
authors.lastname: Hadda
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
authors.forename: Ghias
authors.initials: G
authors.lastname: Uddin
authors.affiliation: Department of Bio-Technology, Shaheed Benazir Bhutto University Sheringal Dir (Upper), KP, Pakistan.
authors.forename: Muhammad Asif
authors.initials: MA
authors.lastname: Nawaz
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Bina S
authors.initials: BS
authors.lastname: Siddiqui
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Muslim
authors.initials: M
authors.lastname: Raza
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Saudi Arabia.
authors.forename: Saud
authors.initials: S
authors.lastname: Bawazeer
authors.affiliation: Deparment of Biology, University of Selcuk, Konya, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Zengin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D029788:Diospyros / Q000737:chemistry*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009285:Naphthoquinones / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: C517013:7-methyljuglone; D000975:Antioxidants; D006993:Hypnotics and Sedatives; D009285:Naphthoquinones; D010936:Plant Extracts
keywords: 7-methyljuglone; Diospyros lotus L.; Docking study; Gaba; Medicinal plants; Sedative-hypnotic activity