title: A systematic review on ethnomedicines of anti-cancer plants.
abstract: Cancer is a serious health problem and the second leading cause of death around the globe. Present review is an attempt to provide utmost information based on ethno-pharmacological and toxicological aspects of anti-cancer plants of the world. A total of 276 articles published in English journals and containing maximum ethnomedicinal information were reviewed using several data sources such as; Google scholar, Web of Science, Scopus, PubMed and floras of different countries. A total of 199 anti-cancer plants were recorded in present review and results indicated that traditional medicines are mostly being use in developing countries for cancer treatment. Traditionally and scientifically skin and breast cancer types gained more focus. Seventy plants were reportedly analyzed for in-vitro activities while 32 plants were having in-vivo reports. Twenty nine pure compounds (mostly phenolic) were reportedly isolated from anti-cancer plants and tested against different cancer cell lines. Inspite having better efficiency of ethnomedicines as compared to synthetic drugs, several plants have also shown toxic effects on living system. Therefore, we invite researchers attention to carry out detailed ethno-pharmacological and toxicological studies on un-explored anti-cancer plants in order to provide reliable knowledge to the patients and develop novel anti-cancer drugs. Copyright © 2017 John Wiley & Sons, Ltd.
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Akash
authors.initials: A
authors.lastname: Tariq
authors.affiliation: College of life sciences, Beijing Normal University, Beijing, China.
authors.forename: Sehrish
authors.initials: S
authors.lastname: Sadia
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Pan
authors.affiliation: Center for Agricultural Resources Research, Chinese Academy of Sciences, Shijiazhuang, Hebei, China.
authors.forename: Ihteram
authors.initials: I
authors.lastname: Ullah
authors.affiliation: Department of Botany, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Sakina
authors.initials: S
authors.lastname: Mussarat
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.|University of Chinese Academy of Sciences, Beijing, China.|Department of Botany, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
authors.forename: Olatunji Olusanya
authors.initials: OO
authors.lastname: Abiodun
authors.affiliation: Institute of Botany, Chinese Academy of Sciences, Beijing, China.
authors.forename: Altanzagas
authors.initials: A
authors.lastname: Batbaatar
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Dagang
authors.initials: D
authors.lastname: Song
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Qinli
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Chemistry, Government College Ara Khel, Frontier Region Kohat, Pakistan.
authors.forename: Riaz
authors.initials: R
authors.lastname: Ullah
authors.affiliation: Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Suliman
authors.initials: S
authors.lastname: Khan
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.|Central Department of Biotechnology, Tribhuvan University, Kathmandu, Nepal.
authors.forename: Buddha Bahadur
authors.initials: BB
authors.lastname: Basnet
authors.affiliation: Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Brawin
authors.initials: B
authors.lastname: Kumar
authors.affiliation: Department of Crop Physiology and Ecology, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh.|Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Rabiul
authors.initials: R
authors.lastname: Islam
authors.affiliation: Department of Botany, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Adnan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020834:Ethnopharmacology / Q000379:methods*; D006801:Humans; D008519:Medicine, Traditional / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer; ethnomedicines; pharmacology; phytocompounds; toxicology