title: Iridium-Catalyzed Asymmetric Hydrogenation of Ketones with Accessible and Modular Ferrocene-Based Amino-phosphine Acid (f-Ampha) Ligands.
abstract: A series of tridentate ferrocene-based amino-phosphine acid (f-Ampha) ligands have been successfully developed. The f-Ampha ligands are extremely air stable and exhibited excellent performance in the Ir-catalyzed asymmetric hydrogenation of ketones (full conversions, up to >99% ee, and 500 000 TON). DFT calculations were performed to elucidate the reaction mechanism and the importance of the -COOH group. Control experiments also revealed that the -COOH group played a key role in this reaction.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Yu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Long
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen, Guangdong 518055, P. R. China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Weilong
authors.initials: W
authors.lastname: Wu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xue
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen, Guangdong 518055, P. R. China.
authors.forename: Lung Wa
authors.identifier: 0000-0001-9460-7812
authors.initials: LW
authors.lastname: Chung
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.|Department of Chemistry, South University of Science and Technology of China , Shenzhen, Guangdong 518055, P. R. China.
authors.forename: Xumu
authors.identifier: 0000-0001-5700-0608
authors.initials: X
authors.lastname: Zhang