title: Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates.
abstract: We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates.
authors.affiliation: Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia. niveen.khashab@kaust.edu.sa.
authors.forename: P A T
authors.initials: PA
authors.lastname: Martins
authors.affiliation: Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia. niveen.khashab@kaust.edu.sa.
authors.forename: S
authors.initials: S
authors.lastname: Alsaiari
authors.affiliation: Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia. niveen.khashab@kaust.edu.sa.
authors.forename: K
authors.initials: K
authors.lastname: Julfakyan
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
authors.forename: Z
authors.identifier: http://orcid.org/0000-0001-9639-905X
authors.initials: Z
authors.lastname: Nie
authors.affiliation: Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia. niveen.khashab@kaust.edu.sa.
authors.forename: N M
authors.identifier: http://orcid.org/0000-0003-2728-0666
authors.initials: NM
authors.lastname: Khashab
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000648:ultrastructure; D003474:Curcumin / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007259:Infrared Rays; D008027:Light; D008074:Lipoproteins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010446:Peptide Fragments / Q000032:analysis* / Q000648:ultrastructure; D066329:Protein Aggregates / Q000528:radiation effects; D013050:Spectrometry, Fluorescence / Q000379:methods; D013696:Temperature
chemical_list: D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D008074:Lipoproteins; D010446:Peptide Fragments; D066329:Protein Aggregates; C075222:amyloid beta-protein (1-42); D006046:Gold; D003474:Curcumin