title: Isoindolinones via Copper-Catalyzed Intramolecular Benzylic C-H Sulfamidation.
abstract: 2-Benzyl-N-tosylbenzamides and related substrates undergo copper-catalyzed intramolecular sulfamidation at the benzylic methylene to give N-arylsuflonyl-1-arylisoindolinones, which can be N-deprotected using samarium iodide to generate the free 1-arylisoindolinones. Preliminary mechanistic studies indicate that the rate-determining step is not C-H bond cleavage but are instead consistent with slow oxidation of a copper π-arene intermediate.
authors.affiliation: School of Chemistry, University of Bristol , Bristol BS8 1TS, U.K.
authors.forename: Robin B
authors.identifier: 0000-0002-8021-8768
authors.initials: RB
authors.lastname: Bedford
authors.affiliation: School of Chemistry, University of Bristol , Bristol BS8 1TS, U.K.
authors.forename: John G
authors.initials: JG
authors.lastname: Bowen
authors.affiliation: School of Chemistry, University of Bristol , Bristol BS8 1TS, U.K.
authors.forename: Carolina
authors.initials: C
authors.lastname: Méndez-Gálvez