title: A Case-Based Approach to Evaluate the Potential Risks Associated with Fluoroquinolones and Steroids.
abstract: Fluoroquinolones (FQs) are a frequently prescribed class of antibacterial agents. FQs are widely used but may carry serious side effects particularly pronounced in older adults, and the Food and Drug Administration recently suggested FQs should not be routinely used in certain conditions if alternative options are available. Research has demonstrated that the risk of tendinitis and tendon rupture associated with FQs is one of the highest in older adults who are concurrently treated with steroids. Health care providers and pharmacists involved in the treatment of older adults should be aware of this potential drug interaction, which may lead to serious side effects and safety concerns.
authors.forename: Timothy
authors.initials: T
authors.lastname: Nguyen
authors.forename: Karin
authors.initials: K
authors.lastname: Gelband
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D019338:Polypharmacy; D011241:Prednisone / Q000009:adverse effects*; D012307:Risk Factors; D012422:Rupture, Spontaneous; D013256:Steroids / Q000009:adverse effects*; D052256:Tendinopathy / Q000139:chemically induced* / Q000175:diagnosis; D013708:Tendon Injuries / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000900:Anti-Bacterial Agents; D013256:Steroids; D002939:Ciprofloxacin; D011241:Prednisone