title: Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia.
authors.affiliation: Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yoshida
authors.affiliation: Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.|Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakaguchi
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Muramatsu
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.|Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
authors.forename: Y
authors.identifier: 0000-0003-3139-9272
authors.initials: Y
authors.lastname: Okuno
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, USA.
authors.forename: C
authors.initials: C
authors.lastname: Song
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Dovat
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shimada
authors.affiliation: Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ozeki
authors.affiliation: Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ohnishi
authors.affiliation: Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Teramoto
authors.affiliation: Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukao
authors.affiliation: Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kojima
mesh_terms: D000818:Animals; D018450:Disease Progression; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics*; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000473:pathology; D007223:Infant; D051379:Mice; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D051881:Receptor, Notch1 / Q000235:genetics
chemical_list: C497239:IKZF1 protein, human; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1; D051740:Ikaros Transcription Factor