title: Improved Arousal and Motor Function Using Zolpidem in a Patient With Space-Occupying Intracranial Lesions: A Case Report.
abstract: Patients with disorders of consciousness (DOC) have profound functional limitations with few treatment options for improving arousal and quality of life. Zolpidem is a nonbenzodiazepine hypnotic used to treat insomnia that has also been observed to paradoxically improve arousal in those with DOC, such as the vegetative or minimally conscious states. Little information exists on its use in patients with DOC who have intracranial space-occupying lesions. We present a case of a 24-year-old man in a minimally conscious state due to central nervous system lymphoma who was observed to have increased arousal and improved motor function after the administration of zolpidem.
  
  
  METHODS
  V.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Michigan, 325 E. Eisenhower Pkwy, Ste 100, Ann Arbor, MI 48108(∗). Electronic address: mbomalas@med.umich.edu.
authors.forename: Martin Nicholas
authors.initials: MN
authors.lastname: Bomalaski
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI(†).
authors.forename: Sean Robinson
authors.initials: SR
authors.lastname: Smith
mesh_terms: D001143:Arousal / Q000187:drug effects; D001932:Brain Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D003244:Consciousness Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000209:etiology; D005500:Follow-Up Studies; D058785:GABA-A Receptor Agonists / Q000008:administration & dosage*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D018458:Persistent Vegetative State / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011725:Pyridines / Q000008:administration & dosage*; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult; D000077334:Zolpidem
chemical_list: D058785:GABA-A Receptor Agonists; D011725:Pyridines; D000077334:Zolpidem