title: Two cases of serious rhabdomyolysis during linezolid treatment.
abstract: Linezolid is an oxazolidinone antibiotic with activity against gram-positive organisms, particularly methicillin-resistant Staphylococcus aureus (MRSA). To the best of our knowledge, there are only two case reports on rhabdomyolysis in patients treated with linezolid. Here, we describe two cases of serious rhabdomyolysis: one in a patient with septic community-acquired (CA)-MRSA pneumonia and a second case in a patient with suspected catheter-related blood stream infection.
authors.affiliation: Division Medizinische Mikrobiologie, Paracelsus Medizinische Universität Salzburg, Universitätsinstitut für Medizinisch-Chemische Labordiagnostik, Muellner Hauptstrasse 48, 5020, Salzburg, Austria. a.lechner@salk.at.
authors.forename: Arno M
authors.initials: AM
authors.lastname: Lechner
authors.affiliation: Landesapotheke Salzburg, Muellner Hauptstrasse 50, 5020, Salzburg, Austria. e.past@salk.at.
authors.forename: Eva
authors.initials: E
authors.lastname: Past
authors.affiliation: Landesapotheke Salzburg, Muellner Hauptstrasse 50, 5020, Salzburg, Austria.
authors.forename: Ulla
authors.initials: U
authors.lastname: Porsche
authors.affiliation: Division Medizinische Mikrobiologie, Paracelsus Medizinische Universität Salzburg, Universitätsinstitut für Medizinisch-Chemische Labordiagnostik, Muellner Hauptstrasse 48, 5020, Salzburg, Austria.
authors.forename: Jan M
authors.initials: JM
authors.lastname: Kern
authors.affiliation: Paracelsus Medizinische Universität Salzburg, Universitätsklinik für Innere Medizin II, Muellner Hauptstrasse 48, 5020, Salzburg, Austria.
authors.forename: Uta
authors.initials: U
authors.lastname: Hoppe
authors.affiliation: Paracelsus Medizinische Universität Salzburg, Universitätsklinik für Innere Medizin II, Muellner Hauptstrasse 48, 5020, Salzburg, Austria.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Pretsch
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001317:Austria; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007194:India; D000069349:Linezolid / Q000633:toxicity*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000502:physiology; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000069349:Linezolid
keywords: Linezolid; MRSA pneumonia; MRSA sepsis; Rhabdomyolysis