title: Integration of multiple active sites on large-pore mesoporous silica for enantioselective tandem reactions.
abstract: Facile construction of a multifunctional heterogeneous catalyst through the assembly of Au/carbene and chiral ruthenium/diamine dual complexes in large-pore mesoporous silica was developed. This enables an efficient one-pot hydration-asymmetric transfer hydrogenation enantioselective tandem reaction of haloalkynes, affording chiral halohydrins with up to 99% enantioselectivity. Combined multifunctionalities, such as substrate-promoted silanol-functionality, BF4-anion-bonding gold/carbene and covalent-bonding chiral ruthenium/diamine active centers, contributed cooperatively to the catalytic performance.
authors.affiliation: Key Laboratory of Resource Chemistry of Ministry of Education, Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China. ghliu@shnu.edu.cn.
authors.forename: Xuelin
authors.initials: X
authors.lastname: Xia
authors.forename: Jingjing
authors.initials: J
authors.lastname: Meng
authors.forename: Hanxin
authors.initials: H
authors.lastname: Wu
authors.forename: Tanyu
authors.initials: T
authors.lastname: Cheng
authors.forename: Guohua
authors.initials: G
authors.lastname: Liu