title: Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats.
abstract: This study investigated the effect of saponins (20-100mg/kg) from Tithonia diversifolia leaf (STD) on the liver, kidney, heart, lipid profile and hematological parameters of normal rats. The results showed that STD (20-100mg/kg) though caused a slight increase in the liver, heart and kidney activity of ALT, AST, ALP and GGT (p<0.05), did not result in corresponding increase in the serum level of these enzymes. A significant reduction in the level of triglycerides, LDL and cholesterol, creatinine, urea, LDH, PCV and hemoglobin were observed with a concomitant increase in HDL, white blood cell and lymphocyte. These study demonstrated the role of STD in enhancing immune response and in reducing cholesterol and triglycerides in normal rats at studied dosages.
authors.affiliation: Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria; Department of Biochemistry, University of Ado-Ekiti, Ekiti State, Nigeria.
authors.forename: Oluwamodupe Cecilia
authors.initials: OC
authors.lastname: Ejelonu
authors.affiliation: Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria. Electronic address: olusola.elekofehinti@aaua.edu.ng.
authors.forename: Olusola Olalekan
authors.initials: OO
authors.lastname: Elekofehinti
authors.affiliation: Department of Biochemistry, University of Ado-Ekiti, Ekiti State, Nigeria.
authors.forename: Isaac Gbadura
authors.initials: IG
authors.lastname: Adanlawo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D019659:Asteraceae / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D006321:Heart / Q000187:drug effects; D007107:Immune System / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D012503:Saponins; D014280:Triglycerides; D014508:Urea; D002784:Cholesterol; D003404:Creatinine
keywords: Heart; Hematology; Kidney; Lipid profile; Liver; Tithonia diversifolia