title: Wide field and highly sensitive angiography based on optical coherence tomography with akinetic swept source.
abstract: Wide-field vascular visualization in bulk tissue that is of uneven surface is challenging due to the relatively short ranging distance and significant sensitivity fall-off for most current optical coherence tomography angiography (OCTA) systems. We report a long ranging and ultra-wide-field OCTA (UW-OCTA) system based on an akinetic swept laser. The narrow instantaneous linewidth of the swept source with its high phase stability, combined with high-speed detection in the system enable us to achieve long ranging (up to 46 mm) and almost negligible system sensitivity fall-off. To illustrate these advantages, we compare the basic system performances between conventional spectral domain OCTA and UW-OCTA systems and their functional imaging of microvascular networks in living tissues. In addition, we show that the UW-OCTA is capable of different depth-ranging of cerebral blood flow within entire brain in mice, and providing unprecedented blood perfusion map of human finger invivo. We believe that the UW-OCTA system has promises to augment the existing clinical practice and explore new biomedical applications for OCT imaging.
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.
authors.forename: Jingjiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.
authors.forename: Shaozhen
authors.initials: S
authors.lastname: Song
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
keywords: (110.4500) Optical coherence tomography; (140.3600) Lasers, tunable; (170.0110) Imaging systems; (170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging