title: Comparison between solid component size on thin-section CT and pathologic lymph node metastasis and local invasion in T1 lung adenocarcinoma.
abstract: OBJECTIVE
  To correlate the tumor size and solid component size on thin-section CT (TS-CT) with pathological findings including lymph node (LN) metastasis and local invasion in T1 lung adenocarcinoma.
  
  
  METHODS
  188 patients with surgically resected T1 lung adenocarcinoma were retrospectively analyzed. Two chest radiologists measured the long-axis and short-axis dimensions of nodules and solid components with a lung and/or a mediastinal window setting (WS) on TS-CT. After analyzing interobserver agreement, average long-axis dimensions of the measured tumors and solid components were correlated with pathological findings.
  
  
  RESULTS
  Seven of 188 patients (3.7%) had pathologic LN-positive metastasis. In patients in whom the long axis of the solid component was <5 mm with a mediastinal WS or <8 mm with a lung WS on TS-CT, no LN metastases were observed, resulting in a positive predictive value (PPV) for predicting a pathologic LN-negative status of 100% with each WS. Based on the same diagnostic criteria, the PPVs for a pathological local invasion (LI)-negative status were 91 (40/44) and 90% (55/61), respectively.
  
  
  CONCLUSIONS
  Solid component size on TS-CT may have the potential to predict LN-negative or LI-negative status.
authors.affiliation: Unit of Translational Medicine, Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hayashi
authors.affiliation: Unit of Translational Medicine, Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. ashi@nagasaki.u.ac.jp.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Ashizawa
authors.affiliation: Department of Radiology, Nagasaki Prefectural Shimabara Hospital, Nagasaki, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ogihara
authors.affiliation: Department of Radiological Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Nishida
authors.affiliation: Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Yamasaki
authors.affiliation: Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagayasu
authors.affiliation: Unit of Translational Medicine, Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuda
authors.affiliation: Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Sumihisa
authors.initials: S
authors.lastname: Honda
authors.affiliation: Department of Radiological Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Uetani
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008867:Microtomy / Q000379:methods; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
keywords: Adenocarcinoma; CT; Ground-glass opacity; Lung neoplasms; Lymph node metastasis