title: Dabigatran etexilate in a vitamin-K antagonist non responder patient during Heartware HVAD support.
abstract: We report a case of a patient supported with a HeartWare left ventricular assist device for idiopathic cardiomyopathy who was resistance to vitamin-K antagonists three months after implantation. The patient initially started low-molecular-weight heparin therapy and then, after the onset of an ischemic stroke, switched to dabigatran etexilate (DE). The patient had progressive recovery of cardiac function for which the device was explanted. No thrombotic or bleeding events occurred during DE therapy.
authors.affiliation: Division of Cardiac Surgery, San Giovanni Battista Hospital "Molinette", University of Turin, Turin, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Baronetto
authors.affiliation: Division of Cardiac Surgery, San Giovanni Battista Hospital "Molinette", University of Turin, Turin, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Centofanti
authors.affiliation: Division of Cardiac Surgery, San Giovanni Battista Hospital "Molinette", University of Turin, Turin, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Attisani
authors.affiliation: Division of Cardiac Surgery, San Giovanni Battista Hospital "Molinette", University of Turin, Turin, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Boffini
authors.affiliation: Division of Cardiac Surgery, San Giovanni Battista Hospital "Molinette", University of Turin, Turin, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Ricci
authors.affiliation: Division of Cardiac Surgery, San Giovanni Battista Hospital "Molinette", University of Turin, Turin, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Simonato
authors.affiliation: Division of Cardiac Surgery, San Giovanni Battista Hospital "Molinette", University of Turin, Turin, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Rinaldi
mesh_terms: D000368:Aged; D000991:Antithrombins / Q000008:administration & dosage; D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D000069604:Dabigatran / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006353:Heart-Assist Devices / Q000009:adverse effects; D006801:Humans; D011182:Postoperative Care / Q000379:methods*; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000991:Antithrombins; D014812:Vitamin K; D000069604:Dabigatran
keywords: dabigatran etexilate; heart failure; ventricular assist device