title: [Research progress of miRNAs targeting GSK-3β in regulation of hepatocellular carcinoma invasion and metastasis].
abstract: Invasion and metastasis are key factors contributing to the high mortality rate of patients with hepatocellular carcinoma (HCC) involving a complex mechanism. In the invasion and metastasis of HCC, miRNAs can serve as either oncogenes or tumor suppressor genes to regulate the differentiation and proliferation of tumor cells being and play important roles in tumorigenesis, angiogenesis, invasion and metastasis. This review summarizes the recent progress in research of the molecular mechanisms by which miRNAs targeting GSK-3β regulate HCC invasion and metastasis and examines the roles of miRNAs in hepatocellular carcinoma cell proliferation, apoptosis, invasion, metastasis, and GSK-3β regulation.
authors.affiliation: College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Song-Qi
authors.initials: SQ
authors.lastname: He
authors.forename: Bin
authors.initials: B
authors.lastname: Wen
authors.forename: Guan-Xin
authors.initials: GX
authors.lastname: Chen
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Sun
authors.forename: Jia-Ling
authors.initials: JL
authors.lastname: Sun
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Yang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000473:pathology* / Q000556:secondary*; D002454:Cell Differentiation / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D000071679:Glycogen Synthase Kinase 3 beta