title: A meta-analysis of three identified single nucleotide polymorphisms at 1p13.3 and 1q41 and their associations with lipid levels and coronary artery disease.
abstract: The aim of this meta-analysis was to detect whether three identified single nucleotide polymorphisms (SNPs) (rs646776, rs599839, and rs17465637) at 1p13.3 and 1q41 are associated with lipid levels and the risk of coronary artery disease (CAD). Databases of MEDLINE, EMBASE, the Cochrane Library, and BIOSIS were systematically searched. The pooled effects were expressed as odds ratio or standardized mean difference or mean difference with 95% confidence intervals. A total of 14 studies with 57,916 patients were included in the meta-analysis. Pooled effects showed that the AA group of 1p13.3 rs599839 had higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC), and lower high-density lipoprotein cholesterol (HDLC) levels than the GA/GG group, and the CAD group had higher AA genotype frequency than the control group. The TT group of 1p13.3 rs646776 had higher TC and LDLC levels and lower HDLC levels than the CT/CC group. The CAD group also had higher CC genotype frequency of 1q41 rs17465637 than the control group. The SNPs of 1p13 rs599839 and rs646776 were associated with serum lipid levels. The genetic variants of 1p13 rs599839 and 1q41 rs17465637 SNPs were prominently related to CAD, and the genetic variants of chromosome 1p13 promote the risk of CAD by increased TC and LDLC levels and decreased HDLC levels.
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.
authors.forename: Qian-Chao
authors.initials: QC
authors.lastname: He
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Hu
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.
authors.forename: Qing-Ping
authors.initials: QP
authors.lastname: Zhang
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Tan
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.
authors.forename: Tai
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.
authors.forename: Yue-Qiang
authors.initials: YQ
authors.lastname: Hu
authors.affiliation: Department of Internal Medicine, Affiliated Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China. Electronic address: liangnisci@126.com.
authors.forename: Ni
authors.initials: N
authors.lastname: Liang
mesh_terms: D000368:Aged; D000483:Alleles; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002878:Chromosomes, Human, Pair 1 / Q000737:chemistry*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
keywords: Coronary artery disease; Meta-analysis; Polymorphisms; Serum lipid levels; Three SNPs at 1p13.3 and 1q41