title: [Clinical efficacy and safety of controlled-release dinoprostone insert: a multicenter retrospective study].
abstract: OBJECTIVE
  To analyze the effectiveness and safety of controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province.
  
  
  METHODS
  Twenty hospitals using controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province were stratified into provincial hospitals and municipal hospitals, and three hospitals of each level were selected as research units. According to the inclusion and exclusion criteria, 1390 pregnant women receiving term labor induction using controlled-release dinoprostone insert were retrospectively analyzed to evaluate the the effectiveness and safety with another 957 pregnant women with induced abortion using oxytocin as the control group.
  
  
  RESULTS
  Compared with the control group, the controlled-release dinoprostone insert group showed a significantly longer length of the latent phase of labor (4.06∓2.65 vs 3.20∓2.08 h, P=0.003, 95%CI [0.182, 0.920]) and shorter lengths of the active phase (1.73∓1.32 vs 2.22∓1.75 h, P=0.000, 95%CI [-0.795, -0.363]) and the second stage of labor (0.49∓0.37 vs 0.54∓0.43 h, P=0.003, 95%CI [-0.137, -0.028]). No significant differences were found in the length of the first stage of labor, the vaginal delivery rate, adverse reactions, or fetal outcomes between the two groups.
  
  
  CONCLUSIONS
  Controlled-release dinoprostone insert is effective and safe for labor induction at term.
authors.affiliation: Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: lixy8752@163.com.
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Li
authors.forename: Yue-Wen
authors.initials: YW
authors.lastname: Guo
authors.forename: Yan-Wen
authors.initials: YW
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
authors.forename: Xue-Xue
authors.initials: XX
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Wang
authors.forename: Dun-Jin
authors.initials: DJ
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: An
mesh_terms: D000028:Abortion, Induced; D000282:Administration, Intravaginal; D016022:Case-Control Studies; D003692:Delayed-Action Preparations; D015232:Dinoprostone / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007751:Labor, Induced; D007743:Labor, Obstetric / Q000187:drug effects; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003692:Delayed-Action Preparations; D010120:Oxytocics; D015232:Dinoprostone