title: PSMA-targeted contrast agents for intraoperative imaging of prostate cancer.
abstract: Prostate-specific membrane antigen (PSMA) can serve as a molecular cell surface target for the detection and treatment of prostate cancer. Near-infrared (NIR) fluorescence imaging enables highly sensitive, rapid, and non-radioactive imaging of PSMA, though specific targeting still remains a challenge because no optimized contrast agents exist.
authors.affiliation: Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA 02114, USA. hchoi12@mgh.harvard.edu.
authors.forename: Kai
authors.initials: K
authors.lastname: Bao
authors.forename: Jeong Heon
authors.initials: JH
authors.lastname: Lee
authors.forename: Homan
authors.initials: H
authors.lastname: Kang
authors.forename: G Kate
authors.initials: GK
authors.lastname: Park
authors.forename: Georges
authors.initials: G
authors.lastname: El Fakhri
authors.forename: Hak Soo
authors.initials: HS
authors.lastname: Choi
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D003287:Contrast Media / Q000032:analysis* / Q000737:chemistry; D043425:Glutamate Carboxypeptidase II / Q000032:analysis*; D006801:Humans; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging; D061848:Optical Imaging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D000954:Antigens, Surface; D003287:Contrast Media; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II