title: Neutrophils in Homeostasis, Immunity, and Cancer.
abstract: Neutrophils were among the first leukocytes described and visualized by early immunologists. Prominent effector functions during infection and sterile inflammation classically placed them low in the immune tree as rapid, mindless aggressors with poor regulatory functions. This view is currently under reassessment as we uncover new aspects of their life cycle and identify transcriptional and phenotypic diversity that endows them with regulatory properties that extend beyond their lifetime in the circulation. These properties are revealing unanticipated roles for neutrophils in supporting homeostasis, as well as complex disease states such as cancer. We focus this review on these emerging functions in order to define the true roles of neutrophils in homeostasis, immunity, and disease.
authors.affiliation: Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 20829, Spain.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Nicolás-Ávila
authors.affiliation: Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 20829, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Adrover
authors.affiliation: Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 20829, Spain; Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich 80539, Germany. Electronic address: ahidalgo@cnic.es.
authors.forename: Andrés
authors.initials: A
authors.lastname: Hidalgo
mesh_terms: D000818:Animals; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*