title: Highly biocompatible chitosan with super paramagnetic calcium ferrite (CaFe2O4) nanoparticle for the release of ampicillin.
abstract: The CaFe2O4nanoparticles (CFNP) were synthesized using the solution combustion method. The CFNP-chitosan-ampicillin was prepared by the ionic gelation method using tripolyphosphate (TPP). The CFNP, chitosan-CFNP, chitosan-CFNP-ampicillin materials were characterized by XRD, FT-IR and TGA analysis in order to evaluate the particle nature and size, the presence of functional groups and their thermal stability. The FESEM and EDAX analysis were performed to understand the surface morphology of the materials and the presence of CFNP in the material, respectively. The vibrating sample magnetometer (VSM) analysis was performed to analyze the magnetic property of the chitosan-CFNP material. The squareness value of 0.1733 obtained by VSM measurements indicates the super paramagnetic nature of chitosan-CFNP. Taguchi orthogonal array method was applied to identify the significant impacting parameters for maximizing the drug encapsulation of chitosan-CFNP. The drug release studies showed that the drug was released rapidly in acidic medium as compared to the basic or neutral medium. The drug release kinetic data were fitted with different linear kinetic model equations and the best fit was obtained with Korsmeyer-Peppas model. The model drug ampicillin release from chitosan-CFNP was tested against staphylococcus epidermis bacteria through disc diffusion method for checking biocompatibility and antibacterial activity.
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli, 620 015 Tamilnadu, India.
authors.forename: Ram
authors.initials: R
authors.lastname: Bilas
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli, 620 015 Tamilnadu, India.
authors.forename: K
authors.initials: K
authors.lastname: Sriram
authors.affiliation: Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620 015 Tamilnadu, India.
authors.forename: P Uma
authors.initials: PU
authors.lastname: Maheswari
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli, 620 015 Tamilnadu, India. Electronic address: meerasheriffa@gmail.com.
authors.forename: K M Meera
authors.initials: KM
authors.lastname: Sheriffa Begum
mesh_terms: D000667:Ampicillin / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D004337:Drug Carriers; D005290:Ferric Compounds; C000617020:calcium ferrite; D000667:Ampicillin; D048271:Chitosan
keywords: Ampicillin; CaFe(2)O(4); Chitosan; Drug delivery; Optimization; Taguchi