title: Gray Matter Atrophy within the Default Mode Network of Fibromyalgia: A Meta-Analysis of Voxel-Based Morphometry Studies.
abstract: Over the years, studies have demonstrated morphological changes in the brain of fibromyalgia (FMS). We aimed to conduct a coordinate-based meta-analytic research through systemic review on voxel-based morphometry (VBM) imaging results to identify consistent gray matter (GM) difference between FMS patients and healthy subjects. We performed a comprehensive literature search in PubMed (January 2000-December 2015) and included six VBM publication on FMS. Stereotactic data were extracted from 180 patients of FMS and 123 healthy controls. By means of activation likelihood estimation (ALE) technique, regional GM reduction in left medial prefrontal cortex and right dorsal posterior cingulate cortex was identified. Both regions are within the default mode network. In conclusion, the gray matter deficit is related to the both affective and nonaffective components of pain processing. This result also provided the neuroanatomical correlates for emotional and cognitive symptoms in FMS.
authors.affiliation: Department of Psychiatry, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chemin
authors.identifier: 0000-0001-6889-4686
authors.initials: C
authors.lastname: Lin
authors.affiliation: College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Shwu-Hua
authors.identifier: 0000-0001-5606-1118
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Radiology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Diagnostic Radiology, Chiayi Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Chiayi, Taiwan; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan; Department of Psychology, National Chung Cheng University, Chiayi, Taiwan; Department of Imaging Physics, Division of Diagnostic Imaging, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Hsu-Huei
authors.identifier: 0000-0002-2020-8912
authors.initials: HH
authors.lastname: Weng
mesh_terms: D005260:Female; D005356:Fibromyalgia / Q000473:pathology / Q000503:physiopathology; D066128:Gray Matter / Q000473:pathology / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology