title: Diagnosis, treatment, and outcomes of infantile spasms in the Trisomy 21 population.
abstract: OBJECTIVE
  To determine if there are differences in the timing of diagnosis and response to treatment between infants with infantile spasms (IS) and Trisomy 21 (T21) and those with idiopathic IS.
  
  
  METHODS
  This was a retrospective study evaluating the time from onset of IS to diagnosis, treatment of IS, time from treatment to resolution of IS, and development of epilepsy in children with T21 and IS compared to children with idiopathic IS.
  
  
  RESULTS
  Thirteen children with T21 and IS were identified over a 10 year period and compared to 32 children in the control group. There was no significant difference in age of onset, time between onset and diagnosis, or acute response to treatment. However, the children with idiopathic IS were more likely to go on to develop epilepsy than those with T21 and IS (41% vs. 0, p=0.006).
  
  
  CONCLUSIONS
  The children with T21 and IS were diagnosed and treated similarly to those patients with idiopathic IS. There were no significant differences in the age of onset, time between the onset and diagnosis of IS, or acute treatment response of IS between the T21 and control groups. However those with T21 and IS had a lower risk of subsequent epilepsy following IS than those with idiopathic IS. IS in the T21 population appears to be inherently different from IS of unknown etiology.
authors.affiliation: Department of Neurology, University of Washington, Division of Pediatric Neurology, Seattle Children's Hospital, 4800 Sand Point Way NE, MB.7.420, Seattle, WA, 98105, USA. Electronic address: Christopher.Beatty@seattlechildrens.org.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Beatty
authors.affiliation: Department of Neurology, University of Washington, Division of Pediatric Neurology, Seattle Children's Hospital, 4800 Sand Point Way NE, MB.7.420, Seattle, WA, 98105, USA; Department of Pediatrics, Division of Pulmonary and Sleep Medicine, Seattle Children's Hospital, 4800 Sand Point Way NE, OC.7.720, Seattle, WA, 98105, USA. Electronic address: Joanna.Wrede@seattlechildrens.org.
authors.forename: Joanna E
authors.initials: JE
authors.lastname: Wrede
authors.affiliation: Department of Neurology, University of Washington, Division of Pediatric Neurology, Seattle Children's Hospital, 4800 Sand Point Way NE, MB.7.420, Seattle, WA, 98105, USA. Electronic address: Heidi.Blume@seattlechildrens.org.
authors.forename: Heidi K
authors.initials: HK
authors.lastname: Blume
mesh_terms: D000293:Adolescent; D002648:Child; D004314:Down Syndrome / Q000150:complications*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013036:Spasms, Infantile / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
keywords: Down syndrome; Epileptic spasms; Idiopathic infantile spasms; Infantile spasms; Trisomy 21; West syndrome