title: [A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis].
abstract: Acute rhinosinusitis is leading in frequency of antibiotic prescribing all over the world. At the same time the problem of antibiotic resistance and safety of antimicrobial drugs becomes more relevant and international. The article describes the basic mechanisms of bacterial resistance and growth of side effects when using macrolides, respiratory fluoroquinilones and β-lactam antibiotics of different types. Formation of IgE-mediated cephalosporin allergy is associated with the side R1 chain. The R1 structure of cephalosporins I and II generations is similar to penicillins, thus creating conditions for cross-allergy progression. R1 of cephalosporins III and IV generations is represented by a qualitatively different chemical compound (aminothiazol-oxime group) that increases the level of tolerance to these antibiotic types. The data of surveillance study are given to evaluate the efficacy and safety of the new drug Spectracef (active substance is cephalosporin of III generation Cefditoren) when treating acute bacterial rhinosinusitis on an outpatient basis.
authors.affiliation: Central State Medical Academy of Department for Presidential Affairs of the Russian Federation, Moscow, Russia, 121359.
authors.forename: E L
authors.initials: EL
authors.lastname: Savlevich
authors.affiliation: Central State Medical Academy of Department for Presidential Affairs of the Russian Federation, Moscow, Russia, 121359.
authors.forename: V S
authors.initials: VS
authors.lastname: Kozlov
authors.affiliation: Polyclinic #5 of Department for Presidential Affairs of the Russian Federation, Moscow, Russia, 119121.
authors.forename: M A
authors.initials: MA
authors.lastname: Zharkykh
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012220:Rhinitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C057710:cefditoren pivoxil