title: [The individual and combined antioxidant effects of citicoline and ethylmethylhydroxypyridini succinas].
abstract: OBJECTIVE
  To study the antioxidant status of patients with chronic cerebral ischemia (CCI) during the individual treatment with 2-ethyl-6-methyl-3-hydroxypyridine-succinate (neurox) and in the combination with citicoline (neipilept).
  
  
  METHODS
  A study included 40 patients, 18 men and 22 women, aged from 54 to 72 years, with CCI, stage 2, at the decompensation stage complicated with the hypertensive crisis and/or arrhythmia.
  
  
  CONCLUSIONS
  A significant increase in the serum superoxide dismutase activity after the complex therapy with neurox and neipilept was demonstrated compared to patients treated with neurox. A study of reduced sulfur-hydroxy groups in patients treated with 2-ethyl-6-methyl-3-hydroxypyridine-succinate and patients treated with the combination of 2-ethyl-6-methyl-3-hydroxypyridine-succinate and citicoline, revealed a significant increase in the number of reduced SH- groups after the treatment with neurox compared to the combined use of neurox and neipilept.
authors.affiliation: Pirogov Russian National Research Medical University.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Solovyeva
authors.affiliation: Pirogov Russian National Research Medical University.
authors.forename: A N
authors.initials: AN
authors.lastname: Karneev
authors.affiliation: Pirogov Russian National Research Medical University.
authors.forename: A V
authors.initials: AV
authors.lastname: Chekanov
authors.affiliation: Pirogov Russian National Research Medical University.
authors.forename: O A
authors.initials: OA
authors.lastname: Baranova
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018697:Nootropic Agents; D010847:Picolines / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D018697:Nootropic Agents; D010847:Picolines; C070020:emoxypine succinate; D003566:Cytidine Diphosphate Choline