title: Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability.
abstract: A dual redox and biorelevant triggered supramolecular system is developed through noncovalent supramolecular inclusion interactions between the ferrocene (Fc) modified on camptothecin (CPT) and β-cyclodextrin (β-CD) at the end of methoxy polyethylene glycol (mPEG). With these two segments, a stable noncovalent supramolecular structure, i.e., mPEG-β-CD/Fc-CPT, can be formed, and then self-assembled into micellar structures in water. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells. The cytotoxicity evaluation of mPEG-β-CD also indicated good biocompatibility. In vivo results revealed the mPEG-β-CD/Fc-CPT nanoparticles had higher in vivo efficacy without side effects. It is anticipated this supramolecular complex may serve as a new kind of promising alternative for drug delivery systems.
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, Sichuan, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Kang
authors.affiliation: State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institute of Sichuan University , Chengdu 610065, Sichuan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ju
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, Sichuan, China.
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institute of Sichuan University , Chengdu 610065, Sichuan, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, Sichuan, China.
authors.forename: Bang-Jing
authors.identifier: http://orcid.org/0000-0002-0405-6883
authors.initials: BJ
authors.lastname: Li
keywords: drug carrier; micelles; redox-responsive; self-assembly; supramolecular