title: Current Bioengineering and Regenerative Strategies for the Generation of Kidney Grafts on Demand.
abstract: Currently in the USA, one name is added to the organ transplant waiting list every 15 min. As this list grows rapidly, fewer than one-third of waiting patients can receive matched organs from donors. Unfortunately, many patients who require a transplant have to wait for long periods of time, and many of them die before receiving the desired organ. In the USA alone, over 100,000 patients are waiting for a kidney transplant. However, it is a problem that affects around 6% of the word population. Therefore, seeking alternative solutions to this problem is an urgent work. Here, we review the current promising regenerative technologies for kidney function replacement. Despite many approaches being applied in the different ways outlined in this work, obtaining an organ capable of performing complex functions such as osmoregulation, excretion or hormone synthesis is still a long-term goal. However, in the future, the efforts in these areas may eliminate the long waiting list for kidney transplants, providing a definitive solution for patients with end-stage renal disease.
authors.affiliation: Instituto de Ciencia y Tecnología Animal, Universidad Politécnica de Valencia, C/Camino de Vera s/n, 46022, Valencia, Spain.
authors.forename: Ximo
authors.initials: X
authors.lastname: García-Domínguez
authors.affiliation: Instituto de Ciencia y Tecnología Animal, Universidad Politécnica de Valencia, C/Camino de Vera s/n, 46022, Valencia, Spain.
authors.forename: Jose S
authors.initials: JS
authors.lastname: Vicente
authors.affiliation: Servicio de Urología, Hospital Universitari i Politècnic La Fe, Avinguda de Fernando Abril Martorell, 106, 46026, Valencia, Spain.
authors.forename: Cesar D
authors.initials: CD
authors.lastname: Vera-Donoso
authors.affiliation: Instituto de Ciencia y Tecnología Animal, Universidad Politécnica de Valencia, C/Camino de Vera s/n, 46022, Valencia, Spain. fmarco@dca.upv.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Marco-Jimenez
mesh_terms: D000818:Animals; D057005:Bioengineering / Q000379:methods; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D012038:Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells
keywords: Blastocyst complementation; Decellularization; Kidney disease; Kidney engineering; Kidney regeneration; Stem cells