title: MoO3-xquantum dots for photoacoustic imaging guided photothermal/photodynamic cancer treatment.
abstract: A theranostic system of image-guided phototherapy is considered as a potential technique for cancer treatment because of the ability to integrate diagnostics and therapies together, thus enhancing accuracy and visualization during the treatment. In this work, we realized photoacoustic (PA) imaging-guided photothermal (PT)/photodynamic (PD) combined cancer treatment just via a single material, MoO3-xquantum dots (QDs). Due to their strong NIR harvesting ability, MoO3-xQDs can convert incident light into hyperthermia and sensitize the formation of singlet oxygen synchronously as evidenced by in vitro assay, hence, they can behave as both PT and PD agents effectively and act as a "dual-punch" to cancer cells. In a further study, elimination of solid tumors from HeLa-tumor bearing mice could be achieved in a MoO3-xQD mediated phototherapeutic group without obvious lesions to the major organs. In addition, the desired PT effect also makes MoO3-xQDs an exogenous PA contrast agent for in vivo live-imaging to depict tumors. Compared with previously reported theranostic systems that put several components into one system, our multifunctional agent of MoO3-xQDs is exempt from unpredictable mutual interference between components and ease of leakage of virtual components from the composited system.
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn and School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Ding
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn and School of Life and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn.
authors.forename: Chongshen
authors.identifier: http://orcid.org/0000-0002-8000-7434
authors.initials: C
authors.lastname: Guo
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn and School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Jianzhe
authors.initials: J
authors.lastname: Sun
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn and School of Life and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Zheng
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn and School of Life and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn.
authors.forename: Mei
authors.initials: M
authors.lastname: Yan
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. chongshenguo@hit.edu.cn and School of Life and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Shaoqin
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D005260:Female; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008982:Molybdenum / Q000737:chemistry*; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000628:therapy; D010087:Oxides / Q000737:chemistry*; D061088:Photoacoustic Techniques; D010789:Phototherapy; D045663:Quantum Dots; D000068936:Theranostic Nanomedicine
chemical_list: D010087:Oxides; C082290:molybdenum trioxide; D008982:Molybdenum