title: Ductal Carcinoma in situ Detected during Prospective MR Imaging Screening of a Woman with a BRCA2 Mutation: The First Case Report in Japan.
abstract: The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. This case is significant and it verifies the importance of MRI screening in breast or ovarian cancer-free BRCA1/2 mutation carriers who do not exhibit positive mammographic or ultrasonographic findings.
authors.affiliation: Department of Radiology, Sagara Hospital Affiliated Breast Center.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tozaki
authors.affiliation: Division of Breast Surgical Oncology, Department of Surgery, Showa University School of Medicine.
authors.forename: Seigo
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Breast Surgical Oncology, Breast Oncology Center, Cancer Institute Hospital.
authors.forename: Dai
authors.initials: D
authors.lastname: Kitagawa
authors.affiliation: Breast Surgical Oncology, Breast Oncology Center, Cancer Institute Hospital.
authors.forename: Takuji
authors.initials: T
authors.lastname: Iwase
authors.affiliation: Division of Pathology, Cancer Institute Hospital.
authors.forename: Rie
authors.initials: R
authors.lastname: Horii
authors.affiliation: Division of Pathology, Cancer Institute Hospital.
authors.forename: Futoshi
authors.initials: F
authors.lastname: Akiyama
authors.affiliation: Department of Clinical Genetic Oncology, Cancer Institute Hospital.
authors.forename: Masami
authors.initials: M
authors.lastname: Arai
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009154:Mutation; D011446:Prospective Studies
keywords: BRCA2; ductal carcinoma in situ; hereditary breast and ovarian cancer syndrome; magnetic resonance imaging