title: Dimorphic placental stress: A repercussion of interaction between endocrine disrupting chemicals (EDCs) and fetal sex.
abstract: Placental homeostasis is critical for fetal development as it determines the health of mother and fetus during pregnancy and in later life. Interestingly even the fetus, in a sexually dimorphic manner, influences the pedantic growth and development of placenta. Although placenta is thought to act as a protective barrier against chemical exposures, certain endocrine disrupting chemicals (EDCs) that are circulating in mother's blood tend to cross placenta. These EDCs have been reported to cause changes in expression levels of certain genes, immunogenic factors and non-coding RNAs such as micro RNA (miRNA) and long non-coding RNA (lncRNA) leading to placental stress. We hypothesize that these changes in placenta occur in a sexually dimorphic manner as a result of interaction between EDC exposure and fetal sex. Therefore, we propose that the ability of placenta to respond and buffer EDC exposure depends on fetal sex and, hence the EDC associated disease susceptibility of one sex differs from the other.
authors.affiliation: Endocrine Disruptors and Reproductive Toxicology (EDART) Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India; Centre for Human Genetics (CHG), Biotech Park, Electronic City Phase 1, Bangalore 560100, Karnataka, India.
authors.forename: Surbhi
authors.initials: S
authors.lastname: Sood
authors.affiliation: Endocrine Disruptors and Reproductive Toxicology (EDART) Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India; Centre for Human Genetics (CHG), Biotech Park, Electronic City Phase 1, Bangalore 560100, Karnataka, India.
authors.forename: Sudhanshu
authors.initials: S
authors.lastname: Shekhar
authors.affiliation: Endocrine Disruptors and Reproductive Toxicology (EDART) Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India; P.G. Research Department of Advanced Zoology and Biotechnology, Government Arts and Science College for Men, Nandanam, Chennai 600035, Tamil Nadu, India. Electronic address: santoshmcc@yahoo.com.
authors.forename: Winkins
authors.initials: W
authors.lastname: Santosh
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000009:adverse effects*; D044127:Epigenesis, Genetic; D005260:Female; D047109:Fetal Development; D020022:Genetic Predisposition to Disease; D006706:Homeostasis; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D035683:MicroRNAs / Q000378:metabolism; D008962:Models, Theoretical; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D011256:Pregnancy Outcome; D022661:RNA, Untranslated / Q000378:metabolism; D012737:Sex Factors
chemical_list: D052244:Endocrine Disruptors; D035683:MicroRNAs; D022661:RNA, Untranslated
keywords: Disease susceptibility; Endocrine disrupting chemicals (EDCs); Fetal sex; Placental stress; Sexual dimorphism