title: Antibody-secreting plasma cells persist for decades in human intestine.
abstract: Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19+PC subset was dynamically exchanged, whereas of two CD19-PC subsets, CD45+PCs exhibited little and CD45-PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45-PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19-PC subsets support selection and maintenance of protective PCs for life in human intestine.
authors.affiliation: Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway ole.jorgen.bjarnason.landsverk@rr-research.no frode.lars.jahnsen@rr-research.no.
authors.forename: Ole J B
authors.identifier: 0000-0002-1367-2397
authors.initials: OJ
authors.lastname: Landsverk
authors.affiliation: Department of Immunology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
authors.forename: Omri
authors.initials: O
authors.lastname: Snir
authors.affiliation: Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
authors.forename: Raquel Bartolomé
authors.identifier: 0000-0002-8966-9047
authors.initials: RB
authors.lastname: Casado
authors.affiliation: Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
authors.forename: Lisa
authors.identifier: 0000-0002-0769-619X
authors.initials: L
authors.lastname: Richter
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
authors.forename: Jeff E
authors.identifier: 0000-0003-2195-2978
authors.initials: JE
authors.lastname: Mold
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.|Center for Neuroscience and Cell Biology, University of Coimbra, 3000-213 Coimbra, Portugal.
authors.forename: Pedro
authors.initials: P
authors.lastname: Réu
authors.affiliation: Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
authors.forename: Rune
authors.identifier: 0000-0002-8034-7877
authors.initials: R
authors.lastname: Horneland
authors.affiliation: Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
authors.forename: Vemund
authors.identifier: 0000-0003-1303-3250
authors.initials: V
authors.lastname: Paulsen
authors.affiliation: Department of Gastrointestinal Surgery, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
authors.forename: Sheraz
authors.identifier: 0000-0002-5696-2319
authors.initials: S
authors.lastname: Yaqub
authors.affiliation: Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.|Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
authors.forename: Einar Martin
authors.initials: EM
authors.lastname: Aandahl
authors.affiliation: Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway.
authors.forename: Ole M
authors.identifier: 0000-0001-6615-3542
authors.initials: OM
authors.lastname: Øyen
authors.affiliation: Department of Informatics, University of Oslo, 0313 Oslo, Norway.
authors.forename: Hildur Sif
authors.initials: HS
authors.lastname: Thorarensen
authors.affiliation: Department of Physics and Astronomy, Ion Physics, Uppsala University, 752 36 Uppsala, Sweden.
authors.forename: Mehran
authors.identifier: 0000-0003-2787-8801
authors.initials: M
authors.lastname: Salehpour
authors.affiliation: Department of Physics and Astronomy, Ion Physics, Uppsala University, 752 36 Uppsala, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Possnert
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
authors.forename: Jonas
authors.identifier: 0000-0001-5819-458X
authors.initials: J
authors.lastname: Frisén
authors.affiliation: Department of Immunology, Centre for Immune Regulation and KG Jebsen Coeliac Disease Research Centre, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
authors.forename: Ludvig M
authors.initials: LM
authors.lastname: Sollid
authors.affiliation: Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway.
authors.forename: Espen S
authors.identifier: 0000-0002-5890-9108
authors.initials: ES
authors.lastname: Baekkevold
authors.affiliation: Department of Pathology, Centre for Immune Regulation, Oslo University Hospital-Rikshospitalet and The University of Oslo, 0372 Oslo, Norway ole.jorgen.bjarnason.landsverk@rr-research.no frode.lars.jahnsen@rr-research.no.
authors.forename: Frode L
authors.initials: FL
authors.lastname: Jahnsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000921:Antibody-Producing Cells / Q000276:immunology; D018941:Antigens, CD19 / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D007422:Intestines / Q000276:immunology*; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology*
chemical_list: D018941:Antigens, CD19; C000604811:CD19 molecule, human; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human