title: Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of the Strawberry: A Potent Supplementary Fruit.
abstract: The study was designed to assess the effect of different strawberry extracts on glucose levels, lipid profiles, and oxidative stress in nicotinamide-streptozotocin (NIC-STZ) induced diabetic rats. The associated changes were evaluated through biochemical, molecular, and histological assays. Diabetes was induced by intraperitoneal injection of STZ to albino Wistar rats after treatment with nicotinamide. Aqueous, hydroalcoholic, and alcoholic strawberry extracts were administrated orally to diabetic rats. Treatment of strawberry extracts improved lipid profile, liver function, and serum creatinine and led to a significant increase in antioxidant status in diabetic rats. Real-time PCR expression analysis of genes from the liver of animals treated with strawberry extracts exhibited downregulation of several fatty acid synthesis genes, transcription factors, such as Sterol regulatory Element Binding Transcription factor (SREBP) and Nuclear Factor-κβ (NF-κβ), and inflammatory markers, like Interleukin 6 (IL6) and Tumor Necrosis Factor-α (TNF-α). Strawberry extracts also upregulated liver Peroxisome Proliferator Activated Receptor-γ (PPAR-γ). Histological examination confirmed the nephroprotective and β-cell regeneration/protection effects of strawberry extracts. The present study demonstrates several beneficial effects of strawberry extracts along with its probable mechanism of action.
authors.affiliation: Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Katraj, Pune, Maharashtra 411043, India. mandavepallavi@gmail.com.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Mandave
authors.affiliation: Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Katraj, Pune, Maharashtra 411043, India. spkhadke@gmail.com.
authors.forename: Suresh
authors.initials: S
authors.lastname: Khadke
authors.affiliation: Department of Pathology, Bharati Vidyapeeth Medical College, Bharati Vidyapeeth Deemed University, Pune-Satara Road, Pune, Maharashtra 411043, India. manjiri.karandikar@bharatividyapeeth.edu.
authors.forename: Manjiri
authors.initials: M
authors.lastname: Karandikar
authors.affiliation: Department of Pharmacology, Bharati Vidyapeeth Medical College, Bharati Vidyapeeth Deemed University, Pune-Satara Road, Pune, Maharashtra 411043, India. vijaya.pandit@bharatividyapeeth.edu.
authors.forename: Vijaya
authors.initials: V
authors.lastname: Pandit
authors.affiliation: Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Katraj, Pune, Maharashtra 411043, India. pranjekar@gmail.com.
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Ranjekar
authors.affiliation: Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Katraj, Pune, Maharashtra 411043, India. aniket.kuvalekar@bharatividyapeeth.edu.
authors.forename: Aniket
authors.initials: A
authors.lastname: Kuvalekar
authors.affiliation: School of Science, RMIT University, Melbourne 3000, Australia. nitin.mantri@rmit.edu.au.
authors.forename: Nitin
authors.initials: N
authors.lastname: Mantri
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental; D019587:Dietary Supplements; D004195:Disease Models, Animal; D031985:Fragaria / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D018836:Inflammation Mediators; D008055:Lipids; D010936:Plant Extracts; D020011:Protective Agents
keywords: antihyperglycemic activity; normolipidemic activity; oxidative stress; strawberry; β-cell regeneration/protection effects