title: Synthesis, pH dependent photometric and electrochemical investigation, redox mechanism and biological applications of novel Schiff base and its metallic derivatives.
abstract: A novel Schiff base, 1-((2, 4-dimethylphenylimino)methyl)naphthalen-2-ol abbreviated as (HL) and its four metallic complexes were synthesized and confirmed by1H and13C NMR, FTIR, TGA and UV-Visible spectroscopy. Schiff base was also characterized by X-ray analysis. The photometric and electrochemical responses of all the synthesized compounds were investigated in a wide pH range. Structures of the compounds were optimized computationally for the evaluation of different physico-chemical parameters. On the basis of electrochemical results the redox mechanistic pathways of the compounds were proposed. The cytotoxicity analysis on Hela cells revealed that HL and its complexes inhibit cell growth as revealed from their IC50 values (HL):106.7μM, (L2VO): 40.66μM, (L2Sn): 5.92μM, (L2Zn): 42.82 and (L2Co): 107.68μM. The compounds were tested for anti-diabetic, triglyceride, cholesterol, anti-microbial, anti-fungal and enzyme inhibition activities. The results revealed that HL and its complexes are promising new therapeutic options as these compounds exhibit strong activity against cancer cells, diabetics, fungal and microbial inhibition.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan. Electronic address: afzals_qau@yahoo.com.
authors.forename: Afzal
authors.initials: A
authors.lastname: Shah
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Abdul Aziz
authors.initials: AA
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: aamir@nanoctr.cn.
authors.forename: Aamir Hassan
authors.initials: AH
authors.lastname: Shah
authors.affiliation: Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
authors.forename: Rashda
authors.initials: R
authors.lastname: Abbasi
authors.affiliation: Department of Animal Sciences, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Irfan Zia
authors.initials: IZ
authors.lastname: Qureshi
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Saqib
authors.initials: S
authors.lastname: Ali
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D004563:Electrochemistry / Q000379:methods*; D004583:Electrons; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D057230:Limit of Detection; D008297:Male; D008670:Metals / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008670:Metals; D012545:Schiff Bases; D000469:Alkaline Phosphatase
keywords: Biological activities; Charge transfer; Metal-Schiff base complexes; Redox mechanism; Schiff base