title: Biodegradable Neuro-Compatible Peptide Hydrogel Promotes Neurite Outgrowth, Shows Significant Neuroprotection, and Delivers Anti-Alzheimer Drug.
abstract: A novel neuro-compatible peptide-based hydrogel has been designed and developed, which contains microtubule stabilizing and neuroprotective short peptide. This hydrogel shows strong three-dimensional cross-linked fibrillary networks, which can capture water molecules. Interestingly, this hydrogel serves as excellent biocompatible soft material for 2D and 3D (neurosphere) neuron cell culture and provides stability of key cytoskeleton filaments such as microtubule and actin. Remarkably, it was observed that this hydrogel slowly enzymatically degrades and releases neuroprotective peptide, which promotes neurite outgrowth of neuron cell as well as exhibits excellent neuroprotection against anti-NGF-induced toxicity in neuron cells. Further, it can encapsulate anti-Alzheimer and anticancer hydrophobic drug curcumin, releases slowly, and inhibits significantly the growth of a 3D spheroid of neuron cancer cells. Thus, this novel neuroprotective hydrogel can be used for both neuronal cell transplantation for repairing brain damage as well as a delivery vehicle for neuroprotective agents, anti-Alzheimer, and anticancer molecules.
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal India.
authors.forename: Anindyasundar
authors.initials: A
authors.lastname: Adak
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Das
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal India.
authors.forename: Surajit
authors.initials: S
authors.lastname: Barman
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus , 4 Raja S. C. Mullick Road, Kolkata 700032, India.
authors.forename: Saswat
authors.initials: S
authors.lastname: Mohapatra
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal India.
authors.forename: Debmalya
authors.initials: D
authors.lastname: Bhunia
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal India.
authors.forename: Batakrishna
authors.initials: B
authors.lastname: Jana
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal India.|Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus , 4 Raja S. C. Mullick Road, Kolkata 700032, India.
authors.forename: Surajit
authors.identifier: http://orcid.org/0000-0002-8203-8613
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000544:Alzheimer Disease; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D016501:Neurites; D000071446:Neuronal Outgrowth; D000066829:Neuroprotection; D010455:Peptides
chemical_list: D020100:Hydrogels; D010455:Peptides
keywords: 2D and 3D neuron cell culture; drug delivery; microtubule; neurite outgrowth; neuroprotection; peptide hydrogel