title: The short-term effects of air pollutants on respiratory disease mortality in Wuhan, China: comparison of time-series and case-crossover analyses.
abstract: Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants and respiratory disease mortality with both time-series and time-stratified-case-crossover designs. The generalized additive model (GAM) and the conditional logistic regression model were used to assess the short-term effects of air pollutants on respiratory disease mortality. Stratified analyses were performed by age, sex, and diseases. A 10 μg/m3increment in SO2level was associated with an increase in relative risk for all respiratory disease mortality of 2.4% and 1.9% in the case-crossover and time-series analyses in single pollutant models, respectively. Strong evidence of an association between NO2and daily respiratory disease mortality among men or people older than 65 years was found in the case-crossover study. There was a positive association between air pollutants and respiratory disease mortality in Wuhan, China. Both time-series and case-crossover analyses consistently reveal the association between three air pollutants and respiratory disease mortality. The estimates of association between air pollution and respiratory disease mortality from the case-crossover analysis displayed greater variation than that from the time-series analysis.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Ren
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Duke Kunshan University, 8# Duke Avenue, Kunshan, 215316, China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
authors.forename: Yisi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Chu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, Luoyu Road 129, Wuhan 430079, China.|College of Information Science and Engineering, Wuchang Shouyi University, Wuhan 430064, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, Luoyu Road 129, Wuhan 430079, China.
authors.forename: Liqiao
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xiang
mesh_terms: D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D002681:China / Q000453:epidemiology; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D006813:Humidity; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000032:analysis; D052638:Particulate Matter / Q000032:analysis; D012140:Respiratory Tract Diseases / Q000401:mortality*; D013458:Sulfur Dioxide / Q000032:analysis; D013696:Temperature; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D013458:Sulfur Dioxide; D009585:Nitrogen Dioxide