title: Effect of Probiotic Bacillus Coagulans and Lactobacillus Plantarum on Alleviation of Mercury Toxicity in Rat.
abstract: The objective of this study was to evaluate the efficiency of probiotics (Lactobacillus plantarum and Bacillus coagulans) against mercury-induced toxicity using a rat model. Mercury (Hg) is a widespread heavy metal and was shown to be associated with various diseases. Forty-eight adult male Wistar rats were randomly divided into six groups (control, mercury-only, each probiotic-only, and mercury plus each probiotic group). Hg-treated groups received 10 ppm mercuric chloride, and probiotic groups were administrated 1 × 109CFU of probiotics daily for 48 days. Levels of mercury were determined using cold vapor technique, and some biochemical factors (list like glutathione peroxidase (GPx), superoxide dismutase (SOD), creatinine, urea, bilirubin, alanine transaminase (ALT), and aspartate transaminase (AST)) were measured to evaluate changes in oxidative stress. Oral administration of either probiotic was found to provide significant protection against mercury toxicity by decreasing the mercury level in the liver and kidney and preventing alterations in the levels of GPx and SOD. Probiotic treatment generated marked reduction in the levels of creatinine, urea, bilirubin, ALT, and AST indicating the positive influence of the probiotics on the adverse effects of Hg in the body.
authors.affiliation: Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Majlesi
authors.affiliation: Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. shekar@shirazu.ac.ir.
authors.forename: Seyed Shahram
authors.initials: SS
authors.lastname: Shekarforoush
authors.affiliation: Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Ghaisari
authors.affiliation: Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Nazifi
authors.affiliation: Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Sajedianfard
authors.affiliation: Department of Food Science and Technology, College of Agriculture, Shiraz University, Shiraz, Iran.
authors.forename: Mohammad Hadi
authors.initials: MH
authors.lastname: Eskandari
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D000070000:Bacillus coagulans; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D048191:Lactiplantibacillus plantarum; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008628:Mercury / Q000633:toxicity*; D008630:Mercury Poisoning / Q000628:therapy*; D018384:Oxidative Stress; D019936:Probiotics; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D015415:Biomarkers; D003404:Creatinine; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008628:Mercury; D001663:Bilirubin
keywords: Bacillus coagulans; Lactobacillus plantarum; Mercury; Probiotic; Rat