title: Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography.
abstract: Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speeden faceimaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we present a multimodal ophthalmic imaging system using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (SS-SESLO-OCT) forin vivohuman retinal imaging. SESLO reduces the complexity ofen faceimaging systems by multiplexing spatial positions as a function of wavelength. SESLO image quality benefited from single-mode illumination and multimode collection through a prototype double-clad fiber coupler, which optimized scattered light throughput and reduce speckle contrast while maintaining lateral resolution. Using a shared 1060 nm swept-source, shared scanner and imaging optics, and a shared dual-channel high-speed digitizer, we acquired inherently co-registereden faceretinal images and OCT cross-sections simultaneously at 200 frames-per-second.
authors.affiliation: Current Affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Previous Affiliation: Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Malone
authors.affiliation: Current Affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Previous Affiliation: Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Mohamed T
authors.initials: MT
authors.lastname: El-Haddad
authors.affiliation: Current Affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Previous Affiliation: Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Bozic
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Logan A
authors.initials: LA
authors.lastname: Tye
authors.affiliation: Castor Optics, Montreal, QC H3T 2B1, Canada.
authors.forename: Lucas
authors.initials: L
authors.lastname: Majeau
authors.affiliation: Castor Optics, Montreal, QC H3T 2B1, Canada; Centre d'Optique Photonique et Lasers, Polytechnique Montreal, Department of Engineering Physics, Montreal, QC H3C 3A7, Canada.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Godbout
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
authors.affiliation: Castor Optics, Montreal, QC H3T 2B1, Canada; Centre d'Optique Photonique et Lasers, Polytechnique Montreal, Department of Engineering Physics, Montreal, QC H3C 3A7, Canada.
authors.forename: Caroline
authors.initials: C
authors.lastname: Boudoux
authors.affiliation: Current Affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Joos
authors.affiliation: Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Shriji N
authors.initials: SN
authors.lastname: Patel
authors.affiliation: Current Affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Previous Affiliation: Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Yuankai K
authors.initials: YK
authors.lastname: Tao
keywords: (110.4500) Optical coherence tomography; (170.4460) Ophthalmic optics and devices; (170.5755) Retina scanning