title: Inner salt-shaped small molecular photosensitizer with extremely enhanced two-photon absorption for mitochondrial-targeted photodynamic therapy.
abstract: Herein, we experimentally and theoretically demonstrate an unprecedentedly enhanced two-photon absorption in a small organic molecule by a simple introduction of an inner salt-shaped structure. Moreover, such an inner salt-shaped small molecule also exhibits superior singlet oxygen quantum yield and fascinating structure-inherent mitochondrial-targeting ability for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway.
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China. iamqlfan@njupt.edu.cn.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Hu
authors.forename: Tingchao
authors.initials: T
authors.lastname: He
authors.forename: Rongcui
authors.initials: R
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.forename: Handong
authors.initials: H
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Quli
authors.initials: Q
authors.lastname: Fan
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D011789:Quantum Theory; D012492:Salts / Q000737:chemistry / Q000494:pharmacology; D026082:Singlet Oxygen / Q000737:chemistry; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D017319:Photosensitizing Agents; D012492:Salts; D054852:Small Molecule Libraries; D026082:Singlet Oxygen