title: The role of nuclear factor of activated T cells in pulmonary arterial hypertension.
abstract: Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor about 3 decades ago and was not well studied until the development of immunosuppressant. Numerous studies confirm that calcineurin/NFAT signaling is very important in the development of vasculature and cardiovascular system during embryogenesis and is involved in the development of vascular diseases such as hypertension, atherosclerosis and restenosis. Recent studies demonstrated that NFAT proteins also regulate immune response and vascular cells in the pulmonary microenvironment. In this review, we will discuss how different NFAT isoforms contribute to pulmonary vascular remodeling and potential new therapeutic targets for treating pulmonary arterial hypertension.
authors.affiliation: a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.affiliation: a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
authors.forename: Jinchuan
authors.initials: J
authors.lastname: Yan
authors.affiliation: a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
authors.forename: Peijing
authors.initials: P
authors.lastname: Liu
authors.affiliation: a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
authors.forename: Zhongqun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Wang
authors.affiliation: a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.affiliation: a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
authors.forename: Liangjie
authors.initials: L
authors.lastname: Xu
mesh_terms: D000818:Animals; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism* / Q000503:physiopathology; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D050778:NFATC Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D066253:Vascular Remodeling
chemical_list: D050778:NFATC Transcription Factors
keywords: NFAT; calcineurin; hypoxia; proliferation; pulmonary arterial hypertension; vascular remodeling