title: Pleiotrophin is a driver of vascular abnormalization in glioblastoma.
abstract: In a recent report by Zhanget al., pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory , Uppsala, Sweden.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory , Uppsala, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Dimberg
keywords: ALK; GL261; VEGF; glioblastoma; pleiotrophin; vascular abnormalization