title: Topical 0.1% Bromfenac Sodium for Intraoperative Miosis Prevention and Prostaglandin E2Inhibition in Femtosecond Laser-Assisted Cataract Surgery.
abstract: The purpose of this study was to evaluate the effect of topical 0.1% bromfenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), on intraoperative pupil dilation maintenance and prostaglandin E2(PGE2) inhibition during femtosecond laser-assisted cataract surgery.
  
  
  
  Sixty patients (30 each in study and control groups) were included in this study. The patients received 0.1% bromfenac ophthalmic solution or control placebo twice a day for 3 days before surgery. Pupil size was measured at the initiation of femtosecond laser pretreatment and phacoemulsification. Aqueous humor was collected at the beginning of routine cataract surgery. PGE2levels were measured with an enzyme-linked immunoassay. Laser flare photometry was measured preoperatively and at 1 day postoperatively.
  
  
  
  Compared with untreated patients, the change in pupil size and postoperative day 1 aqueous flare were significantly reduced throughout the operation in the patients treated with 0.1% bromfenac (P < 0.001). Mean PGE2concentrations were also significantly decreased by treatment with 0.1% bromfenac (P < 0.001). The reduction of the pupil area and postoperative day 1 aqueous flare were significantly correlated with PGE2levels (P < 0.001).
  
  
  
  NSAID treatment, when administered before femtosecond laser-assisted cataract surgery, was effective in maintaining intraoperative pupil dilation, preventing miosis, and reducing PGE2levels.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Haotian
authors.initials: H
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Wan
authors.initials: W
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Wu
authors.initials: W
authors.lastname: Xiang
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Weirong
authors.initials: W
authors.lastname: Chen
mesh_terms: D000287:Administration, Topical; D000368:Aged; D001577:Benzophenones / Q000008:administration & dosage / Q000494:pharmacology*; D001969:Bromobenzenes / Q000008:administration & dosage / Q000494:pharmacology*; D002386:Cataract / Q000150:complications / Q000378:metabolism*; D002387:Cataract Extraction; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D007834:Lasers; D008297:Male; D008875:Middle Aged; D015877:Miosis / Q000517:prevention & control*; D011446:Prospective Studies; D058307:Receptors, Prostaglandin E, EP2 Subtype / Q000037:antagonists & inhibitors*; D013997:Time Factors
chemical_list: D001577:Benzophenones; D001969:Bromobenzenes; D058307:Receptors, Prostaglandin E, EP2 Subtype; C053083:bromfenac
keywords: aqueous humor; cataract; prostaglandins; pupil