title: Prognostic Factors after Curative Resection for Single-Lesion Hepatocellular Carcinoma in Patients with Normal Liver Function: A Historical Cohort Study.
abstract: BACKGROUND
  Hepatic resection for hepatocellular carcinoma (HCC) is now established as the treatment most likely to yield the best outcome. We aimed to clarify the risk factors for HCC recurrence after curative resection of single HCC in patients with normal liver function (NLF).
  
  
  METHODS
  The clinical records of 105 patients with NFL and a single HCC less than 5 cm in diameter who had undergone curative liver resection between April 2000 and January 2013 were investigated. We analyzed risk factors for recurrence of HCC.
  
  
  RESULTS
  Forty of the 105 patients suffered recurrence of HCC, and median recurrence-free survival (RFS) was 22.0 (5.1-148.5) months after surgery, and the liver was the most frequent site of recurrence. Univariate analysis showed that limited resection (LR; p = 0.002), the indocyanine green retention rate at 15 min (p = 0.023), C-reactive protein value (p = 0.001), bilirubin value (p = 0.042), neutrophil to lymphocyte ratio (p = 0.042), operation time (p = 0.018), and amount of bleeding (p = 0.011) were associated with RFS. Multivariate analysis showed that LR (p = 0.007) was a significant risk factor associated with RFS.
  
  
  CONCLUSIONS
  LR is a risk factor for HCC recurrence in patients with single-lesion HCC and NLF.
authors.affiliation: Department of Gastroenterological Surgery, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan.
authors.forename: Mitsugi
authors.initials: M
authors.lastname: Shimoda
authors.forename: Kazuma
authors.initials: K
authors.lastname: Tago
authors.forename: Masato
authors.initials: M
authors.lastname: Kato
authors.forename: Taku
authors.initials: T
authors.lastname: Aoki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000368:Aged; D001663:Bilirubin / Q000097:blood; D016063:Blood Loss, Surgical; D002097:C-Reactive Protein / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D004396:Coloring Agents / Q000493:pharmacokinetics; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008113:Liver Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D018655:Lymphocyte Count; D008297:Male; D000072662:Margins of Excision; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009504:Neutrophils; D061646:Operative Time; D012307:Risk Factors; D047368:Tumor Burden
chemical_list: D004396:Coloring Agents; D002097:C-Reactive Protein; D007208:Indocyanine Green; D001663:Bilirubin
keywords: Anatomical resection; Hepatocellular carcinoma; Limited resection