title: Nanoparticles for siRNA-Based Gene Silencing in Tumor Therapy.
abstract: Gene silencing through RNA interference (RNAi) has emerged as a potential strategy in manipulating cancer causing genes by complementary base-pairing mechanism. Small interfering RNA (siRNA) is an important RNAi tool that has found significant application in cancer therapy. However due to lack of stability, poor cellular uptake and high probability of loss-of-function due to degradation, siRNA therapeutic strategies seek safe and efficient delivery vehicles for in vivo applications. The current review discusses various nanoparticle systems currently used for siRNA delivery for cancer therapy, with emphasis on liposome based gene delivery systems. The discussion also includes various methods availed to improve nanoparticle based-siRNA delivery with target specificity and superior efficiency. Further this review describes challenges and perspectives on the development of safe and efficient nanoparticle based-siRNA-delivery systems for cancer therapy.
authors.forename: Anish
authors.initials: A
authors.lastname: Babu
authors.forename: Ranganayaki
authors.initials: R
authors.lastname: Muralidharan
authors.forename: Narsireddy
authors.initials: N
authors.lastname: Amreddy
authors.forename: Meghna
authors.initials: M
authors.lastname: Mehta
authors.forename: Anupama
authors.initials: A
authors.lastname: Munshi
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Ramesh
mesh_terms: D000818:Animals; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000627:therapeutic use; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D034741:RNA, Small Interfering / Q000235:genetics*; D000067492:RNAi Therapeutics / Q000379:methods*
chemical_list: D008081:Liposomes; D034741:RNA, Small Interfering