title: Diagnostic Value of Urine Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Acute Kidney Injury: A Meta-Analysis.
abstract: BACKGROUND
  Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein-7 (IGFBP7) are both involved in renal tubular epithelial cell cycle arrest in acute kidney injury (AKI). Several recent studies showed that urine TIMP-2 times IGFBP7 ([TIMP-2]*[IGFBP7]) is a promising biomarker to predict AKI.
  
  
  METHODS
  The aim of this meta-analysis was to assess the diagnostic value of urine [TIMP-2]*[IGFBP7] for early diagnosis of AKI. Relevant studies were retrieved from the PubMed, EMBASE, and Cochrane Library databases. The sensitivity and specificity were determined, and summary receiver operating characteristic (SROC) curves were constructed.
  
  
  RESULTS
  Ten full-text prospective studies were included in this meta-analysis. The estimated sensitivity of urine [TIMP-2]*[IGFBP7] for the early diagnosis of AKI was 0.84 (95% CI = 0.80-0.88) and the specificity was 0.57 (95%CI = 0.55-0.60). The SROC analysis showed an area under the curve of 0.8813.
  
  
  CONCLUSIONS
  The limited number of included studies, small sample size, unpublished negative results and language limitation might have affected the evaluation.
  
  
  CONCLUSIONS
  Urine [TIMP-2]*[IGFBP7] is a promising candidate for early detection of AKI, especially in ruling-out AKI. However, the potential of this biomarker should be validated in larger studies with a broader spectrum of clinical settings.
authors.affiliation: Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Ultrasonography, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Gong
authors.affiliation: Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Liao
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000652:urine*; D011446:Prospective Studies; D012372:ROC Curve; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000652:urine*
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; C560823:TIMP2 protein, human; C102529:insulin-like growth factor binding protein-related protein 1; D019716:Tissue Inhibitor of Metalloproteinase-2