title: Sevoflurane Alters Spatiotemporal Functional Connectivity Motifs That Link Resting-State Networks during Wakefulness.
abstract: Background:The spatiotemporal patterns of correlated neural activity during the transition from wakefulness to general anesthesia have not been fully characterized. Correlation analysis of blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI) allows segmentation of the brain into resting-state networks (RSNs), with functional connectivity referring to the covarying activity that suggests shared functional specialization. We quantified the persistence of these correlations following the induction of general anesthesia in healthy volunteers and assessed for a dynamic nature over time.Methods:We analyzed human fMRI data acquired at 0 and 1.2% vol sevoflurane. The covariance in the correlated activity among different brain regions was calculated over time using bounded Kalman filtering. These time series were then clustered into eight orthogonal motifs using a K-means algorithm, where the structure of correlated activity throughout the brain at any time is the weighted sum of all motifs.Results:Across time scales and under anesthesia, the reorganization of interactions between RSNs is related to the strength of dynamic connections between member pairs. The covariance of correlated activity between RSNs persists compared to that linking individual member pairs of different RSNs.Conclusions:Accounting for the spatiotemporal structure of correlated BOLD signals, anesthetic-induced loss of consciousness is mainly associated with the disruption of motifs with intermediate strength within and between members of different RSNs. In contrast, motifs with higher strength of connections, predominantly with regions-pairs from within-RSN interactions, are conserved among states of wakefulness and sevoflurane general anesthesia.
authors.affiliation: Department of Electrical and Systems Engineering, Washington University in St. Louis St. Louis, MO, USA.
authors.forename: MohammadMehdi
authors.initials: M
authors.lastname: Kafashan
authors.affiliation: Department of Electrical and Systems Engineering, Washington University in St. LouisSt. Louis, MO, USA; Division of Biology and Biomedical Science, Washington University in St. LouisSt. Louis, MO, USA.
authors.forename: ShiNung
authors.initials: S
authors.lastname: Ching
authors.affiliation: Department of Anesthesiology, Washington University School of Medicine in St. Louis St. Louis, MO, USA.
authors.forename: Ben J A
authors.initials: BJ
authors.lastname: Palanca
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology*; D063132:Connectome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology*; D000077149:Sevoflurane; D014851:Wakefulness
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane
keywords: Kalman filtering; dynamic functional connectivity; resting-state functional MRI; sevoflurane; spatiotemporal analysis