title: New immunohistochemical markers in the differential diagnosisof nonsmall cell lung carcinoma.
abstract: OBJECTIVE
  The aim of this study was to investigate Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in the differential diagnosis and prognosis of nonsmall cell lung cancer.
  
  
  METHODS
  The expression of Napsin-A, NTRK-1, NTRK-2, and Desmoglein-3 was examined by immunohistochemistry in 50 squamous cell carcinomas and 50 adenocarcinomas. Desmocollin-3 was investigated in 29 squamous cell carcinoma and 29 adenocarcinoma cases. Associations between expression profiles of Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in lung cancers and clinicopathological variables were analyzed.
  
  
  RESULTS
  Napsin-A staining was statistically significant in detecting adenocarcinomas versus squamous cell carcinomas. The sensitivity of Napsin-A for adenocarcinomas was 96% and the specificity was 100%. NTRK-2 and Desmocollin-3 staining were statistically significant in detecting squamous cell carcinomas versus adenocarcinomas. Desmoglein-3, Napsin-A, and NTRK-2 had no effect on survival. Disease-free survival time was significantly shorter in cases that were moderately positive with NTRK-1.
  
  
  CONCLUSIONS
  Our data suggest that Napsin-A, NTRK-2, and Desmocollin-3 are useful markers in the differentiation of nonsmall cell lung cancer.
authors.affiliation: Department of Pathology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Ferda
authors.initials: F
authors.lastname: Bir
authors.affiliation: Department of Pathology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Çeliker
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Binnaz Fatma
authors.initials: BF
authors.lastname: Evyapan
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Yaren
authors.affiliation: Department of Family Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Edirne
mesh_terms: D000230:Adenocarcinoma; D016282:Aspartic Acid Endopeptidases; D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung; D002294:Carcinoma, Squamous Cell; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms
chemical_list: D014408:Biomarkers, Tumor; D016282:Aspartic Acid Endopeptidases
keywords: Desmocollin-3; Desmoglein-3; NTRK-1; NTRK-2; Napsin-A; lung cancer