title: Electrospun nanofibre bundles and yarns for tissue engineering applications: A review.
abstract: Nanofibre membranes produced through the electrospinning process have been studied extensively over the past decade for a number of high demand applications including use as tissue engineered scaffolds. Despite possessing desirable properties including high surface area to volume ratios and enhanced mechanical properties, they ultimately suffer from a lack of cellular infiltration. Variations on the process include the production of highly aligned filaments of electrospun fibres referred to as bundles and yarns. Nanofibre bundle and yarn-based scaffolds have been shown to demonstrate superior cell infiltration rates compared to traditional electrospun nonwovens while also offering the capability to be incorporated into a wider array of post-processing technologies. In this review, fibre collection techniques currently employed within the literature for the fabrication of electrospun bundles and yarns along with their applications in the field of tissue engineering will be discussed.
authors.affiliation: Centre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin, Ireland.
authors.forename: Richard A
authors.initials: RA
authors.lastname: O'Connor
authors.affiliation: Centre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin, Ireland.
authors.forename: Garrett B
authors.initials: GB
authors.lastname: McGuinness
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry; D002478:Cells, Cultured; D006801:Humans; D008422:Materials Testing; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D023822:Tissue Engineering / Q000379:methods*
keywords: Tissue engineering; bundles; cell infiltration; electrospinning; nanofibres; yarns