title: Comparative pharmacokinetics of diaveridine in pigs and chickens following single intravenous and oral administration.
abstract: Comparative pharmacokinetic profiles of diaveridine following single intravenous and oral dose of 10 mg/kg body weight in healthy pigs and chickens were investigated, respectively. Concentrations of diaveridine in plasma samples were determined using a validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method. The concentration-time data were subjected to noncompartmental kinetic analysis by WinNonlin program. The corresponding pharmacokinetic parameters in pigs or chickens after single intravenous administration were as follows, respectively: t1/2β(elimination half-life) 0.74 ± 0.28 and 3.44 ± 1.07 h; Vd(apparent volume of distribution) 2.70 ± 0.99 and 3.86 ± 0.92 L/kg; ClB(body clearance) 2.59 ± 0.62 and 0.80 ± 0.14 L/h/kg; and AUC0-∞(area under the blood concentration vs. time curve) 4.11 ± 1.13 and 12.87 ± 2.60 μg∙h/mL. The corresponding pharmacokinetic parameters in pigs or chickens after oral administration were as follows, respectively: t1/2β1.78 ± 0.41 and 2.91 ± 0.57 h; Cmax(maximum concentration) 0.43 ± 0.24 and 1.45 ± 0.57 μg/mL; Tmax(time to reach Cmax) 1.04 ± 0.67 and 3.25 ± 0.71 h; and AUC0-∞1.33 ± 0.55 and 9.28 ± 2.69 μg∙h/mL. The oral bioavailability (F) of diaveridine in pigs or chickens was determined to be 34.6% and 72.2%, respectively. There were significant differences between the pharmacokinetics profiles in these two species.
authors.affiliation: Public Monitoring Center for Agro-product of Guangdong Academy of Agricultural Sciences, Guangzhou, China.|College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Guo
authors.affiliation: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
authors.forename: F
authors.identifier: http://orcid.org/0000-0001-8847-1031
authors.initials: F
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China.
authors.forename: L-G
authors.initials: LG
authors.lastname: Zhou
authors.affiliation: College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China.
authors.forename: X-H
authors.initials: XH
authors.lastname: Huang
authors.affiliation: College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China.
authors.forename: H-Z
authors.initials: HZ
authors.lastname: Ding
authors.affiliation: College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China.
authors.forename: Z-L
authors.initials: ZL
authors.lastname: Zeng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002645:Chickens / Q000378:metabolism*; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D011743:Pyrimidines / Q000493:pharmacokinetics*; D013552:Swine / Q000378:metabolism*
chemical_list: D011743:Pyrimidines; C033222:diaveridine