title: Bronchial thermoplasty in severe asthma in Australia.
abstract: BACKGROUND
  Bronchial thermoplasty (BT) is an approved bronchoscopic intervention for the treatment of severe asthma. However, limited published experience exists outside of clinical trials regarding patient selection and outcomes achieved.
  
  
  OBJECTIVE
  To evaluate the effectiveness and safety of BT in patients with severe asthma encountered in clinical practice.
  
  
  METHODS
  This is a retrospective analysis of the first 'real world' data from Australia. The following outcomes were measured prior to, and 6 months following BT: spirometry, Asthma Control Questionnaire-5 (ACQ-5) score, reliever and preventer medication use and exacerbation history.
  
  
  RESULTS
  Twenty patients were treated from June 2014 to December 2015 at three university teaching hospitals. All subjects met the European Respiratory Society/American Thoracic Society definition of severe asthma. Mean pre-bronchodilator forced expiratory volume in 1 s was 62.8 ± 16.6% predicted (range: 33-95%). All patients were being treated with high dose inhaled corticosteroids, long-acting beta2agonists and long-acting muscarinic antagonists. Ten patients (50%) were taking maintenance oral prednisolone. Most subjects also required at least one of montelukast (65%), omalizumab (30%) and methotrexate (20%). ACQ-5 improved from 3.6 ± 1.1 at baseline to 1.6 ± 1.2 at 6 months, P < 0.001. Short-acting reliever use decreased from a median of 8.0-0.25 puffs/day, P < 0.001, and exacerbations requiring corticosteroids also significantly reduced. Five of 10 patients completely discontinued maintenance oral corticosteroids. Ten patients with a baseline forced expiratory volume in 1 s of <60% predicted significantly improved from 49.2 ± 9.6% to 61.8 ± 17.6%, P < 0.05. Only two procedures required hospitalisation beyond the planned overnight admission.
  
  
  CONCLUSIONS
  BT is a safe procedure which can achieve clinical improvement in those with uncontrolled symptoms and severe airflow obstruction.
authors.affiliation: Department of Thoracic Medicine, Frankston Hospital, Melbourne, Victoria, Australia.|Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Langton
authors.affiliation: Department of Thoracic Medicine, Frankston Hospital, Melbourne, Victoria, Australia.
authors.forename: Joy
authors.initials: J
authors.lastname: Sha
authors.affiliation: Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
authors.forename: Alvin
authors.initials: A
authors.lastname: Ing
authors.affiliation: Department of Thoracic Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Fielding
authors.affiliation: Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia.
authors.forename: Erica
authors.initials: E
authors.lastname: Wood
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D001315:Australia / Q000453:epidemiology; D000074060:Bronchial Thermoplasty / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000639:trends; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index
keywords: airflow obstruction; asthma; asthma management; bronchial thermoplasty; bronchoscopy