title: Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease.
abstract: OBJECTIVE
  Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography.
  
  
  METHODS
  A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI.
  
  
  RESULTS
  Analysis of covariance revealed a significant relationship between the PPAB2B (β - 0.85; 95 CI -1.85--0.16, p < 0.02), WDR12 (β - 1.31; 95 CI -2.19--0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16-0.31, p < 0.01).
  
  
  CONCLUSIONS
  In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.
authors.affiliation: a Department of Pharmacology , Medical University of Gdansk , Gdansk , Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Wirtwein
authors.affiliation: b Department of Clinical Sciences , Lund University , Malmö , Sweden.
authors.forename: Olle
authors.initials: O
authors.lastname: Melander
authors.affiliation: b Department of Clinical Sciences , Lund University , Malmö , Sweden.
authors.forename: Marketa
authors.initials: M
authors.lastname: Sjőgren
authors.affiliation: c Department of Hypertension and Diabetology , Medical University of Gdansk , Gdansk , Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Hoffmann
authors.affiliation: c Department of Hypertension and Diabetology , Medical University of Gdansk , Gdansk , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Narkiewicz
authors.affiliation: d 1st Department of Cardiology , Medical University of Gdansk , Gdansk , Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Gruchala
authors.affiliation: d 1st Department of Cardiology , Medical University of Gdansk , Gdansk , Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Sobiczewski
mesh_terms: D000071118:ADAMTS7 Protein / Q000235:genetics; D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D003971:Diastole; D005260:Female; D015870:Gene Expression; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D049368:Receptors, Lysophosphatidic Acid / Q000235:genetics*; D012107:Research Design; D012189:Retrospective Studies; D012306:Risk; D013599:Systole
chemical_list: D049368:Receptors, Lysophosphatidic Acid; D000071118:ADAMTS7 Protein; C121534:ADAMTS7 protein, human
keywords: DNA polymorphism; coronary artery disease; dipping; hypertension