title: Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina.
abstract: There are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins. Finally, toxic levels of swansonine were identified in the plant. The present investigation allowed to recognize S. rodrigoi Monteiro poisoning as a plant induced α-mannosidosis.
authors.affiliation: Grupo de Trabajo de Patología, Epidemiología e Investigación Diagnóstica, Área de Sanidad Animal-IIACS/INTA, Salta, Argentina; Facultad de Ciencias Veterinarias y Agrarias-UCASAL, Salta, Argentina. Electronic address: micheloud.juan@inta.gob.ar.
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Micheloud
authors.affiliation: Cátedra de Producción Bovina, Universidad Nacional de Jujuy, Jujuy, Argentina.
authors.forename: Raúl
authors.initials: R
authors.lastname: Marin
authors.affiliation: Grupo de Trabajo de Patología, Epidemiología e Investigación Diagnóstica, Área de Sanidad Animal-IIACS/INTA, Salta, Argentina; Facultad de Ciencias Veterinarias y Agrarias-UCASAL, Salta, Argentina.
authors.forename: Luis Adrián
authors.initials: LA
authors.lastname: Colque-Caro
authors.affiliation: Cátedra de Diversidad de las Plantas, Universidad Nacional de Salta, Salta, Argentina.
authors.forename: Olga Gladys
authors.initials: OG
authors.lastname: Martínez
authors.affiliation: Poisonous Plants Research Laboratory, U.S. Department of Agriculture, Agricultural Research Service, Logan, UT, USA.
authors.forename: Dale
authors.initials: D
authors.lastname: Gardner
authors.affiliation: Catedra de Patología General, Facultad de Ciencias Veterinarias-Universidad Nacional de La Plata, Bs As, Argentina.
authors.forename: Eduardo Juan
authors.initials: EJ
authors.lastname: Gimeno
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001118:Argentina; D001259:Ataxia / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary; D002490:Central Nervous System / Q000503:physiopathology; D004032:Diet / Q000662:veterinary; D015511:Goat Diseases / Q000175:diagnosis* / Q000209:etiology; D006041:Goats; D019660:Malvaceae / Q000737:chemistry*; D037121:Plant Lectins / Q000032:analysis; D010939:Plant Poisoning / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D010947:Plants, Toxic / Q000737:chemistry; D017026:Swainsonine / Q000633:toxicity*; D008363:alpha-Mannosidosis / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*
chemical_list: D037121:Plant Lectins; C033619:lentil lectin; D017026:Swainsonine
keywords: Argentinian Northeastern; Poisonous plants; Storage disease; Swainsonine