title: The t(8;21) fusion protein RUNX1-ETO downregulates PKM2 in acute myeloid leukemia cells.
authors.affiliation: a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education , Shanghai Jiao Tong University School of Medicine , Shanghai , China.|b Department of Hematology of the Second Hospital of Dalian Medical University , Institute of Hematopoietic Stem Cell Transplantation of Dalian Medical University , Dalian , China.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Yan
authors.affiliation: c Department of Pathophysiology , Shanghai Second Military Medical University , Shanghai , China.
authors.forename: Yi-Dong
authors.initials: YD
authors.lastname: Li
authors.affiliation: b Department of Hematology of the Second Hospital of Dalian Medical University , Institute of Hematopoietic Stem Cell Transplantation of Dalian Medical University , Dalian , China.
authors.forename: Su-Hui
authors.initials: SH
authors.lastname: Liu
authors.affiliation: a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Yin
authors.affiliation: a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Liu
authors.affiliation: a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Li
authors.initials: L
authors.lastname: Xia
authors.affiliation: a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D009154:Mutation; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D000075142:RUNX1 Translocation Partner 1 Protein / Q000235:genetics / Q000378:metabolism*; D020218:Response Elements; D013963:Thyroid Hormones / Q000235:genetics* / Q000378:metabolism; D014178:Translocation, Genetic; D023041:Xenograft Model Antitumor Assays; D000097810:Thyroid Hormone-Binding Proteins
chemical_list: D002352:Carrier Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D008565:Membrane Proteins; D015514:Oncogene Proteins, Fusion; D000075142:RUNX1 Translocation Partner 1 Protein; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins; C493728:RUNX1 protein, human; C082222:RUNX1T1 protein, human