title: Environmental Chemicals and Aging.
abstract: Innovations in agriculture and medicine as well as industrial and domestic technologies are essential for the growing and aging global population. These advances generally require the use of novel natural or synthetic chemical agents with the potential to affect human health. Here, we attempt to highlight environmental chemicals and select drugs with the potential to exacerbate aging by directly affecting molecular aging cascades focusing particular attention on the brain. Finally, we call attention to some potential fruitful areas of research, particularly with advanced molecular profiling that could aid in prevention or mitigation of environmental chemical toxic influences in the periphery and the brain.
  
  
  
  We briefly summarize new research and highlight a recent study designed to prospectively identify agrochemicals with the potential to induce neurological diseases and place these discoveries into the already rich neurodegeneration and aging literature. Collectively, the research reviewed briefly here highlight chemicals with the true potential to accelerate aging, particularly in the brain, by eliciting elevated free radical stress and mitochondrial dysfunction. We make general recommendations about improved methodological approaches toward identification and regulation of chemicals that are gerontogenic to the brain.
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Sigmund-Freud Str 27, 53127, Bonn, Germany. brandon.pearson@dzne.de.
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Pearson
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Sigmund-Freud Str 27, 53127, Bonn, Germany.
authors.forename: Dan
authors.initials: D
authors.lastname: Ehninger
mesh_terms: D000375:Aging / Q000502:physiology*; D004781:Environmental Exposure; D004787:Environmental Pollution / Q000009:adverse effects*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D018384:Oxidative Stress / Q000502:physiology*
keywords: Aging; Brain; Environmental chemicals; Gerontogen; Mitochondria; Oxidative stress