title: [Risk factors for acute rejection in living-donor kidney transplant recipients in China: a subgroup analysis of a multi-center, registry study].
abstract: Objective:To evaluate pre-and early post-transplantation risk factors for acute rejection(AR) in kidney recipients.Methods:This subgroup analysis of a multi-center registry study was conducted on living-donor kidney transplant recipients in China with 10 years of follow-up. This study analyzed 1 255 recipients including 921 males(73.4%) and with a mean age of (33±10)years. Data from patients were first analyzed with univariate analysis and then multivariate analysis was used for finding out the potential risk factors of AR.Results:A total of 106(8.4%) patients were suspected with AR after kidney transplantation, while 1 149 patients were considered as non-AR. Multivariable analysis demonstrated a significant influence of recipient age and cold ischemia time(CIT) on the occurrence of AR(OR:0.956, 95%CI:0.923-0.990;OR:1.006, 95%CI:1.002-1.011, respectively). The frequency of severe infection was significantly higher in the AR group than non-AR group(38.7% vs 10.8%;P<0.000 1). The occurrence of new-onset diabetes mellitus and tumors was similar in the two groups.Conclusions:Recipient age and CIT are risk factors for AR after living-donor kidney transplantation. Reducing CIT and intensive management of younger recipient could benefit kidney transplant patients.
authors.affiliation: Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: X P
authors.initials: XP
authors.lastname: Hu
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
authors.forename: T Y
authors.initials: TY
authors.lastname: Zhu
authors.forename: J H
authors.initials: JH
authors.lastname: Chen
authors.forename: C X
authors.initials: CX
authors.lastname: Wang
authors.forename: X T
authors.initials: XT
authors.lastname: Li
authors.forename: W J
authors.initials: WJ
authors.lastname: Xue
authors.forename: T
authors.initials: T
authors.lastname: Lin
authors.forename: L K
authors.initials: LK
authors.lastname: Peng
authors.forename: J M
authors.initials: JM
authors.lastname: Tan
authors.forename: G W
authors.initials: GW
authors.lastname: Feng
authors.forename: Z S
authors.initials: ZS
authors.lastname: Chen
authors.forename: W K
authors.initials: WK
authors.lastname: Han
authors.forename: J
authors.initials: J
authors.lastname: Dong
authors.forename: Y
authors.initials: Y
authors.lastname: Fan
authors.forename: X D
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000328:Adult; D002681:China; D003920:Diabetes Mellitus; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D015999:Multivariate Analysis; D012042:Registries; D012307:Risk Factors; D055815:Young Adult