title: Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with increased morbidity and mortality. Atrial fibrosis augments recurrence rate following AF catheter ablation. Osteopontin is a multifunctional molecule involved in several pathophysiological pathways, including fibrosis. Presently described is investigation of relationship between serum osteopontin level and AF recurrence after AF cryoablation.
  
  
  METHODS
  The study was designed to be prospective and observational; 60 patients with paroxysmal (n=47) and persistent (n=13) AF were included. Osteopontin level was measured both before and 6 months after AF ablation with cryoballoon.
  
  
  RESULTS
  Preprocedure and postprocedure osteopontin level did not differ between the 2 groups of AF patients (p=0.286, p=0.493, respectively). Postprocedure osteopontin level was significantly higher compared with preprocedure value (32.18 ng/mL vs 15.58 ng/mL; p=<0.001). Left atrial diameter, AF type, and preprocedure osteopontin level were related to AF recurrence (p≤0.05). An age-adjusted multivariate logistic regression analysis was conducted to determine independent predictors of AF recurrence. Among these, AF type (ß=2.211; p=0.004; odds ratio [OR]: 9.124; 95% confidence interval [CI]: 2.026-41.094) was found to be the most important factor related to AF recurrence. Preprocedure osteopontin level also predicted AF recurrence independently (ß=0.059; p=0.048; OR: 1.061; 95% CI 1.001-1.125).
  
  
  CONCLUSIONS
  Study results revealed persistency of AF and high preprocedure osteopontin level independently predicted AF recurrence in patients undergoing cryoballoon AF ablation. Association of a biochemical marker with AF recurrence might be beneficial to selection of appropriate patients for cryoballoon procedure and assessment of long-term procedural success.
authors.affiliation: Department of Cardiology, İstanbul Medipol University Faculty of Medicine, İstanbul, Turkey. dr_muratgunes@hotmail.com.
authors.forename: Hacı Murat
authors.initials: HM
authors.lastname: Güneş
authors.forename: Gamze
authors.initials: G
authors.lastname: Babur Güler
authors.forename: Ekrem
authors.initials: E
authors.lastname: Güler
authors.forename: Gültekin Günhan
authors.initials: GG
authors.lastname: Demir
authors.forename: Filiz
authors.initials: F
authors.lastname: Kızılırmak Yılmaz
authors.forename: Mehmet Onur
authors.initials: MO
authors.lastname: Omaygenç
authors.forename: Ayşe
authors.initials: A
authors.lastname: İstanbullu Tosun
authors.forename: Taylan
authors.initials: T
authors.lastname: Akgün
authors.forename: Bilal
authors.initials: B
authors.lastname: Boztosun
authors.forename: Fethi
authors.initials: F
authors.lastname: Kılıçarslan
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D001281:Atrial Fibrillation / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D006328:Cardiac Catheterization; D003452:Cryosurgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D015415:Biomarkers; D053495:Osteopontin