title: Reversible and Selective Encapsulation of Dextromethorphan and β-Estradiol Using an Asymmetric Molecular Capsule Assembled via the Weak-Link Approach.
abstract: An allosterically regulated, asymmetric receptor featuring a binding cavity large enough to accommodate three-dimensional pharmaceutical guest molecules as opposed to planar, rigid aromatics, was synthesized via the Weak-Link Approach. This architecture is capable of switching between an expanded, flexible "open" configuration and a collapsed, rigid "closed" one. The structure of the molecular receptor can be completely modulated in situ through the use of simple ionic effectors, which reversibly control the coordination state of the Pt(II) metal hinges to open and close the molecular receptor. The substantial change in binding cavity size and electrostatic charge between the two configurations is used to explore the capture and release of two guest molecules, dextromethorphan and β-estradiol, which are widely found as pollutants in groundwater.
authors.affiliation: Department of Chemistry and International Institute for Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Jose
authors.initials: J
authors.lastname: Mendez-Arroyo
authors.affiliation: Department of Chemistry and International Institute for Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Andrea I
authors.initials: AI
authors.lastname: d'Aquino
authors.affiliation: Department of Chemistry and International Institute for Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Alyssa B
authors.initials: AB
authors.lastname: Chinen
authors.affiliation: Department of Chemistry and International Institute for Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Yashin D
authors.identifier: 0000-0003-2710-6457
authors.initials: YD
authors.lastname: Manraj
authors.affiliation: Department of Chemistry and International Institute for Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Chad A
authors.identifier: 0000-0002-6634-7627
authors.initials: CA
authors.lastname: Mirkin
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D003915:Dextromethorphan / Q000737:chemistry*; D004958:Estradiol / Q000737:chemistry*; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*; D011789:Quantum Theory; D055672:Static Electricity
chemical_list: D056831:Coordination Complexes; D010984:Platinum; D004958:Estradiol; D003915:Dextromethorphan