title: [Immune response and digestive cancers: Prognostic and therapeutic implications].
abstract: The aim of this article is to emphasize the impact of the immune response in digestive cancers, especially from colorectal (CRC) origin. In this setting, an adaptive lymphocytic infiltrate underlines the prognostic impact of the immune response, because it is associated to a favorable outcome. The next challenge will be to validate, in a prospective therapeutic trial, the integration of the immune response as decisional parameter for adjuvant therapy. The immune response is also a predictive parameter in microsatellite instable metastatic CRC, characterized by an adaptive lymphocytic infiltrate, leading to a very high response rate to immune therapies. However, prognostic and predictive biomarkers still need to be optimized in order to better select patients. These data are also valuable for digestive non-colorectal cancers, which are briefly analyzed. The methodology for the assessment of these prognostic and predictive biomarkers, which represents an important issue in precision medicine, is also discussed.
authors.affiliation: Service d'anatomie et cytologie pathologiques, Unicaen, CHU de Caen, université de Caen, 14003 Caen, France. Electronic address: bibeau-f@chu-caen.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bibeau
authors.affiliation: Service d'anatomie et cytologie pathologiques, Unicaen, CHU de Caen, université de Caen, 14003 Caen, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Bazille
authors.affiliation: Service d'anatomie et cytologie pathologiques, AP-HP, hôpitaux universitaires Est-Parisien, hôpital Saint-Antoine, 75012 Paris, France; Université Pierre-et-Marie-Curie - Paris 6, 75005 Paris, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Svrcek
authors.affiliation: Service de pathologie, institut du cancer de Montpellier, 34298 Montpellier, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Pierson
authors.affiliation: Service d'anatomie et cytologie pathologiques, hôpital européen Georges-Pompidou, université Paris Descartes, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Lagorce-Pagès
authors.affiliation: Service d'anatomie et cytologie pathologiques, AP-HP, hôpitaux universitaires Est-Parisien, hôpital Saint-Antoine, 75012 Paris, France; Université Pierre-et-Marie-Curie - Paris 6, 75005 Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Cohen
authors.affiliation: Service d'anatomie et cytologie pathologiques, AP-HP, hôpitaux universitaires Est-Parisien, hôpital Saint-Antoine, 75012 Paris, France; Université Pierre-et-Marie-Curie - Paris 6, 75005 Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: André
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy; D004067:Digestive System Neoplasms / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007167:Immunotherapy / Q000379:methods*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D053842:Microsatellite Instability; D009154:Mutation; D009363:Neoplasm Proteins / Q000502:physiology; D057285:Precision Medicine; D011379:Prognosis; D059467:Transcriptome
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
keywords: Cancers colorectaux; Cancers digestifs; Colorectal cancer; Digestive cancer; Immune response; Prediction; Prognostic; Pronostic; Prédiction; Réponse immune