title: Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China.
abstract: Objective. To study the relationships between IR and glucose and lipid metabolism in far western China and these relationships' ethnic heterogeneity.Methods. From the baseline survey, 419 Uygur cases, 331 Kazak cases, and 220 Han cases were randomly selected, resulting in a total of 970 cases for study. FINS concentration was measured by radioimmunoassay.Results. (1) In the Kazak population, IR was correlated with hyperglycemia; high levels of TC, TG, and LDL-C; and low levels of HDL-C and abdominal obesity (allP< 0.05). (2) In the Uygur population, the influence of IR on hyperglycemia and abdominal obesity was the greatest. In the Kazak population, IR was associated with hyperglycemia most closely. In the Han population, IR may have had an impact on the incidence of low HDL-C levels. (3) After adjusting for sex, age, smoking status, and alcohol consumption, IR was still associated with anomalies in the metabolism of the Uygur, Kazak, and Han populations.Conclusion. IR was involved in the process of glucose and lipid metabolism, and its degree of involvement differed among the ethnicities studied. We could consider reducing the occurrence of abnormal glucose and lipid metabolism by controlling IR and aiming to reduce the prevalence of metabolic syndrome and related diseases.
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Yi-Zhong
authors.initials: YZ
authors.lastname: Yan
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Ru-Lin
authors.initials: RL
authors.lastname: Ma
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Jiao-Long
authors.initials: JL
authors.lastname: Ma
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Hong-Rui
authors.initials: HR
authors.lastname: Pang
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: La-Ti
authors.initials: LT
authors.lastname: Mu
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China; Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, China.
authors.forename: Yu-Song
authors.initials: YS
authors.lastname: Ding
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Liu
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Rui
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Preventive Medicine, University of Shihezi, Shihezi 832000, China; Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi 832000, China.
authors.forename: Shu-Xia
authors.identifier: 0000-0003-3227-0710
authors.initials: SX
authors.lastname: Guo
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D002681:China; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000208:ethnology; D007333:Insulin Resistance / Q000208:ethnology*; D007623:Kazakhstan / Q000208:ethnology; D050356:Lipid Metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood / Q000208:ethnology; D015995:Prevalence; D011863:Radioimmunoassay
chemical_list: D001786:Blood Glucose