title: A Complete Profile on Blind-your-eye MangroveExcoecaria AgallochaL. (Euphorbiaceae): Ethnobotany, Phytochemistry, and Pharmacological Aspects.
abstract: Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances. This article provides a comprehensive review of the complete profile of an important mangrove plantExcoecaria agallochaL. (Euphorbiaceae) and elaborately describing the ethnobotany, phytochemistry, and pharmacological properties. It is used traditionally in the treatment of various diseases such as epilepsy, ulcers, leprosy, rheumatism, and paralysis. The latex obtained from the bark is poisonous in nature and may cause temporary blindness, thus it is also known as the blind-your-eye mangrove plant. Many phytoconstituents were isolated from the plant, which were mainly diterpenoids, triterpenoids, flavonoids, sterols, and few other compounds. The plant also showed many pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory, analgesic, antiulcer, anticancer, antireverse transcriptase, antihistamine-release, antifilarial, DNA damage protective, antidiabetic, and antitumor protecting activities. Hence, this review could help guide researchers anticipating to undertake further investigations in these directions.
authors.affiliation: Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Sumanta
authors.initials: S
authors.lastname: Mondal
authors.affiliation: Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Debjit
authors.initials: D
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
authors.forename: K
authors.initials: K
authors.lastname: Ramakrishna
keywords: Diterpenoids; Euphorbiaceae; Excoecaria agallocha; mangrove; pharmacology; phytoconstituents