title: Aminoleveulinate photodynamic therapy (ALA-PDT) for Bowen's disease in a SLE patient: Case report and literature review.
abstract: We reported a rare case of topical 5-aminolevulinic acid (ALA)-photodynamic therapy (PDT) in the treatment of a systemic lupus erythematosus (SLE) patient with lower limb multiple Bowen's disease (BD). At the end of the treatment, an excellent clinical response was observed and no recurrence of rash after 2 months of treatment. The recovery time was prolonged only after the first treatment, however, no photosensitive phenomena were observed during and after the treatment. This is the first report to describe ALA-PDT for patient-confirmed photosensitivity in an Asian patient. Whether PDT is contraindicated for SLE remains to be discussed, although our findings show that PDT can be used as an alternative therapy for SLE patients with BD who cannot tolerate surgery.
authors.affiliation: Tongji University School of Medicine, Shanghai 200092, PR China; Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lv
authors.affiliation: Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China.
authors.forename: Jie-Chen
authors.initials: JC
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Miao
authors.affiliation: Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China. Electronic address: hongweiwang2005@aliyun.com.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Wang
mesh_terms: D021542:Amino Acids, Neutral / Q000008:administration & dosage*; D001913:Bowen's Disease / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D021542:Amino Acids, Neutral; D017319:Photosensitizing Agents; C013809:5-aminovaleric acid
keywords: Bowen’s disease; Lupus erythematosus; Photodynamic therapy; Photosensitive