title: Current Concepts in Non-Gastrointestinal Stromal Tumor Soft Tissue Sarcomas: A Primer for Radiologists.
abstract: Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist.
authors.affiliation: Department of Radiology, Tata Memorial Centre, Mumbai 400012, India.
authors.forename: Akshay D
authors.initials: AD
authors.lastname: Baheti
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Jyothi P
authors.initials: JP
authors.lastname: Jagannathan
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Ailbhe
authors.initials: A
authors.lastname: O'Neill
authors.affiliation: Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
authors.forename: Harika
authors.initials: H
authors.lastname: Tirumani
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Sree Harsha
authors.initials: SH
authors.lastname: Tirumani
mesh_terms: D006801:Humans; D007890:Leiomyosarcoma / Q000145:classification / Q000000981:diagnostic imaging / Q000235:genetics; D008080:Liposarcoma / Q000145:classification / Q000000981:diagnostic imaging / Q000235:genetics; D012509:Sarcoma / Q000145:classification / Q000000981:diagnostic imaging* / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000235:genetics; D014057:Tomography, X-Ray Computed; D014944:World Health Organization
keywords: Leiomyosarcoma; Liposarcoma; Soft tissue sarcomas; World Health Organization classification