title: Radiosynthesis of no-carrier-addedmeta-[124I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma.
abstract: Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [124I] for a proof of concept study to assess the diagnostic accuracy of [124I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling ofmIBG was achieved via the iododesilylation reaction between [124I]sodium iodide andmeta-trimethylsilylbenzylguanidine. [124I]mIBG was produced in 62-70 % radioiodide incorporation yield from [124I]sodium iodide. The average amount of formulated [124I]mIBG was 359 MBq (range 344-389 MBq) with an average specific radioactivity of 4.1 TBq μmol-1(range 1.8-5.9 TBq μmol-1) at end of synthesis.
authors.affiliation: Wolfson Molecular Imaging Centre, University of Manchester, Manchester, M20 3LJ UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Green
authors.affiliation: Wolfson Molecular Imaging Centre, University of Manchester, Manchester, M20 3LJ UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lowe
authors.affiliation: Wolfson Molecular Imaging Centre, University of Manchester, Manchester, M20 3LJ UK.
authors.forename: Manikandan
authors.identifier: 0000-0003-4443-0785
authors.initials: M
authors.lastname: Kadirvel
authors.affiliation: Wolfson Molecular Imaging Centre, University of Manchester, Manchester, M20 3LJ UK.
authors.forename: Adam
authors.initials: A
authors.lastname: McMahon
authors.affiliation: Cancer Research UK, Angel Building, London, EC1V 4AD UK.
authors.forename: Nigel
authors.initials: N
authors.lastname: Westwood
authors.affiliation: The Institute of Cancer Research, Sutton, London, Surrey SM2 5NG UK.
authors.forename: Sue
authors.initials: S
authors.lastname: Chua
authors.affiliation: Wolfson Molecular Imaging Centre, University of Manchester, Manchester, M20 3LJ UK.
authors.forename: Gavin
authors.initials: G
authors.lastname: Brown
keywords: Meta-iodobenzylguanidine; Neuroblastoma; Positron emission tomography; Radiochemistry; [124I]; mIBG