title: Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae).
abstract: A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3',4', 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1-6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50of 4.6 μM on HeLa.
authors.affiliation: a Faculty of Science, Department of Organic Chemistry , University of Yaoundé I , Yaoundé , Cameroon.
authors.forename: Ghislain Wabo
authors.initials: GW
authors.lastname: Fotso
authors.affiliation: a Faculty of Science, Department of Organic Chemistry , University of Yaoundé I , Yaoundé , Cameroon.
authors.forename: Justin
authors.initials: J
authors.lastname: Kamga
authors.affiliation: b Faculty of Medicine and Biomedical Science, Department of Pharmacognosy and Pharmaceutical Sciences , University of Yaoundé I , Yaoundé , Cameroon.
authors.forename: Bathelemy
authors.initials: B
authors.lastname: Ngameni
authors.affiliation: c Laboratory of chemical Biology, The United Graduate School of Agricultural Sciences , Iwate University , Morioka , Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Uesugi
authors.affiliation: c Laboratory of chemical Biology, The United Graduate School of Agricultural Sciences , Iwate University , Morioka , Japan.
authors.forename: Misa
authors.initials: M
authors.lastname: Ohno
authors.affiliation: c Laboratory of chemical Biology, The United Graduate School of Agricultural Sciences , Iwate University , Morioka , Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Kimura
authors.affiliation: d Research and Analytical Center for giant Molecules, Graduate School of Science , Tohoku University , Sendai , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Momma
authors.affiliation: d Research and Analytical Center for giant Molecules, Graduate School of Science , Tohoku University , Sendai , Japan.
authors.forename: Eunsang
authors.initials: E
authors.lastname: Kwon
authors.affiliation: e Green Asia Education Center , Kyushu University , Fukuoka , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furuno
authors.affiliation: f Faculty of Agriculture, Department of Food, Life, and Environmental Science , Yamagata University , Tsuruoka , Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shiono
authors.affiliation: g Faculty of Science, Department of Chemistry , University of Dschang , Dschang , Cameroon.
authors.forename: Simo K
authors.initials: SK
authors.lastname: Ingrid
authors.affiliation: h Faculty of Science, Department of Chemistry , University of Botswana , Gaborone , Botswana.
authors.forename: Samuel O
authors.initials: SO
authors.lastname: Yeboah
authors.affiliation: a Faculty of Science, Department of Organic Chemistry , University of Yaoundé I , Yaoundé , Cameroon.|b Faculty of Medicine and Biomedical Science, Department of Pharmacognosy and Pharmaceutical Sciences , University of Yaoundé I , Yaoundé , Cameroon.
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
mesh_terms: D031289:Albizzia / Q000737:chemistry / Q000378:metabolism*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D064210:Secondary Metabolism; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D005419:Flavonoids; D013256:Steroids; C000623393:albiziaflavan B; C000623394:chondrillasterol; C051437:butin; C522894:fustin
keywords: Albizia glaberrima var glabrescens Oliv.; Albiziaflavan B; antiproliferative effects; butin; chondrillasterone; fustin