title: Effects of periodontal treatment on primary sjȫgren's syndrome symptoms.
abstract: The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren's Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1β, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients.
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
authors.forename: Lucas Macedo Batitucci
authors.initials: LM
authors.lastname: Ambrósio
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
authors.forename: Emanuel da Silva
authors.initials: ES
authors.lastname: Rovai
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
authors.forename: Bruno Nunes de
authors.initials: BN
authors.lastname: França
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
authors.forename: Danilo Andrés
authors.initials: DA
authors.lastname: Balzarini
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
authors.forename: Ieda Santos
authors.initials: IS
authors.lastname: Abreu
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of General Pathology, São Paulo, SP, Brazil.
authors.forename: Sheyla Batista Bologna
authors.initials: SB
authors.lastname: Lopes
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of General Pathology, São Paulo, SP, Brazil.
authors.forename: Thaís Borguezan
authors.initials: TB
authors.lastname: Nunes
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of General Pathology, São Paulo, SP, Brazil.
authors.forename: Silvia Vanessa
authors.initials: SV
authors.lastname: Lourenço
authors.affiliation: )Universidade de São Paulo - USP, School of Medicine, Division of Rheumatology, São Paulo, SP, Brazil.
authors.forename: Sandra Gofinet
authors.initials: SG
authors.lastname: Pasoto
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Saraiva
authors.affiliation: Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
authors.forename: Marinella
authors.initials: M
authors.lastname: Holzhausen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D058491:Bacterial Load; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000209:etiology* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005883:Gingival Crevicular Fluid; D006801:Humans; D007378:Interleukins / Q000032:analysis; D008137:Longitudinal Studies; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012463:Saliva / Q000737:chemistry; D012472:Salivation / Q000502:physiology; D012636:Secretory Rate; D012859:Sjogren's Syndrome / Q000150:complications* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007378:Interleukins