title: Population genetic data of 38 insertion-deletion markers in six populations of the northern fringe of the Iberian Peninsula.
abstract: Insertion-deletions have been reported very useful markers for forensic purposes. To further deepen in this matter, 38 non-coding bi-allelic autosomal indels were analyzed in 575 individuals representing six populations from the northern fringe of the Iberian Peninsula. Autochthonous populations from the Basque Country, northern Navarre, the Pas Valley in Cantabria and Aragon were analyzed, together with non-autochthonous populations from the Basque Country and northern Navarre. At the intra-population level, all loci analyzed were in Hardy-Weinberg equilibrium except for marker rs33917182 in autochthonous Basques. Linkage disequilibrium (LD) test did not reveal statistically significant allelic association between the different loci pairs in all six populations. Forensic parameters proved to be highly informative in the six populations analyzed, even if a scenario with population substructure and local inbreeding was considered for match probability calculations, and the potential of this indels set to be used in combination with other genetic markers is remarkable. As for inter-population analyses, in general terms the six populations showed low but statistically significant genetic distances. However, though this indels set efficiently differentiate between main ancestries, it does not allow an accurate separation at a local level and, for the time being, their combination with other informative markers is needed to maximize the power to accurately differentiate populations with close genetic ancestry.
authors.affiliation: BIOMICs Research Group, Centro de Investigación "Lascaray" Ikergunea, Universidad del País Vasco UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Cardoso
authors.affiliation: Servicio de Patología - Gipuzkoa - del IVML (Instituto Vasco de Medicina Legal), Dpto. de la Administración de Justicia, Gobierno Vasco, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Sevillano
authors.affiliation: BIOMICs Research Group, Centro de Investigación "Lascaray" Ikergunea, Universidad del País Vasco UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Gamarra
authors.affiliation: Unidad de Medicina Legal, Facultad de Medicina, Universidad de Cantabria, Santander, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Santurtún
authors.affiliation: Departamento de Medicina Legal, Universidad de Zaragoza, Zaragoza, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Martínez-Jarreta
authors.affiliation: BIOMICs Research Group, Centro de Investigación "Lascaray" Ikergunea, Universidad del País Vasco UPV/EHU, Vitoria-Gasteiz, Spain. Electronic address: marian.mdepancorbo@ehu.es.
authors.forename: Marian M
authors.initials: MM
authors.lastname: de Pancorbo
mesh_terms: D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D016133:Polymerase Chain Reaction; D013030:Spain
chemical_list: D005819:Genetic Markers
keywords: Aragon; Autochthonous; Basques; Iberian Peninsula; Indels; Navarre; Pas valley