title: Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice.
abstract: Multiple sclerosis (MS) is a progressive condition affecting the central nervous system (CNS), and is characterized by the development of demyelinated lesions and plaques in the brain and spinal cord. Exercise is beneficial against dementia in elderly patients, so we investigated the effects of exercise on memory in relation to hippocampal demyelination and neuroplasticity in a mouse model of MS (experimental autoimmune encephalomyelitis [EAE]). Mice were randomly divided into three groups: Sham, EAE, and EAE and exercise (EAE+EX). EAE+EX mice exercised five times a week for 4weeks, and all mice performed step-down avoidance tasks in order to verify memory ability. We analyzed changes in myelin basic protein (MBP), 2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNPase), 5-bromo-2'-deoxyuridine (brdU), doublecortin (DCX), bcl-2, bax, TUNEL, caspase-3, and brain derived neurotrophic factor (BDNF) via immunoassay or histological staining. We found decreased memory ability in EAE mice, accompanied by impaired myelination, increased apoptosis and cell proliferation, and decreased BDNF in the hippocampus. The memory decline and changes in demyelination, apoptosis, BDNF, and cell proliferation were partially reversed in EAE+EX mice. Our findings suggest that in patients with MS, regular exercise may benefit cognitive function by rescuing some hippocampal cellular and molecular impairments.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Tae-Woon
authors.initials: TW
authors.lastname: Kim
authors.affiliation: Department of Physical Therapy, College of Health Sciences, Kyungnam University, Changwon, Gyeongsangnam-do, South Korea. Electronic address: sungpt97@kyungnam.ac.kr.
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Sung
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D002454:Cell Differentiation; D049109:Cell Proliferation; D000089662:Doublecortin Protein; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology* / Q000517:prevention & control / Q000523:psychology*; D005081:Exercise Therapy; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D008568:Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D009103:Multiple Sclerosis / Q000503:physiopathology / Q000517:prevention & control / Q000523:psychology; D009186:Myelin Sheath / Q000378:metabolism; D009473:Neuronal Plasticity; D010805:Physical Conditioning, Animal
keywords: BDNF; exercise; memory; multiple sclerosis