title: The regulatory role of long noncoding RNAs in cancer.
abstract: With the advances in genomic analysis technologies, especially next-generation RNA sequencing, a large number of new transcripts have been discovered, leading to better understanding of long noncoding RNAs (lncRNAs). Recent investigations have provided firm evidence for the critical roles of lncRNAs in chromatin modification, gene transcription, RNA splicing, RNA transport and translation. In vitro and in vivo studies have also proven that aberrant lncRNA expression is essential for the initiation and progression of cancers. Due to their unique tissue- and cancer-specific expression profiles, aberrant expression of lncRNAs can be used as reliable prognostic markers for cancer diagnoses and treatment stratification, and lncRNAs are novel therapeutic targets with high therapeutic windows.
authors.affiliation: Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia; The Electron Microscopy Laboratory, Kunming Medical University, 1168 Chunrongxi Road, Chenggong District, Kunming, Yunnan Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia.
authors.forename: Belamy B
authors.initials: BB
authors.lastname: Cheung
authors.affiliation: Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia.
authors.forename: Bernard
authors.initials: B
authors.lastname: Atmadibrata
authors.affiliation: Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia.
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Marshall
authors.affiliation: Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, UNSW Medicine, UNSW Australia, Darlinghurst, NSW 2010, Australia.
authors.forename: Marcel E
authors.initials: ME
authors.lastname: Dinger
authors.affiliation: Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia. Electronic address: tliu@unsw.edu.au.
authors.forename: Pei Y
authors.initials: PY
authors.lastname: Liu
authors.affiliation: Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia; UNSW Centre for Childhood Cancer Research, UNSW Australia, Kensington, Sydney, NSW 2052, Australia. Electronic address: pliu@unsw.edu.au.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
mesh_terms: D015870:Gene Expression; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: Cancer; Gene expression; Long noncoding RNA