title: Effect of Gender Differences on Transplant Kidney Function.
abstract: BACKGROUND
  Transplant kidney function is thought to be affected by sex differences, such as physical conditions including muscle volume, sex hormones, immune responses, and so forth. We examined the effect of sex differences on transplant kidney function.
  
  
  METHODS
  The subjects were selected from kidney transplant recipients, who received kidney transplantation on our hospital between January 2000 and August 2015. Cadaveric donors and parent-child pairs with an age difference were excluded, then we included 47 recipients whose sex was different from the sex of the donor. We compared transplant kidney function between male donors and female recipients group (M→F, n = 20) and female donors and male recipients group (F→M, n = 27).
  
  
  RESULTS
  Nadir creatinine value was higher in the F→M group than in the M→F group (1.09 mg/dL vs 0.76 mg/dL, P < .0001). The estimated glomerular filtration rate (eGFR) was significantly higher in the M→F group than in the F→M group (66.6 mL/min/1.73 m2vs 50.1 mL/min/1.73 m2, P = .002), and eGFR ratio (recipient to donor) was significantly higher in the M→F group than in the F→M group (1.13 vs 0.57, P < .0001). Multiple linear regression analysis showed that the only the sex of the recipient was significant prognostic factor of eGFR after renal transplantation (P = .037).
  
  
  CONCLUSIONS
  The short-term kidney function of the graft from male to female was better than that of the graft from female to male.
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan. Electronic address: uro-yone@naramed-u.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Yoneda
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iemura
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Onishi
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyake
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Anai
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Torimoto
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Aoki
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Saka
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012727:Sex Characteristics; D014019:Tissue Donors