title: Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage.
abstract: Two dimeric diterpenoids, taxodikaloids A (1) and B (2), have been identified from the seeds of Taxodium ascendens. The diterpenoid structures were established on the basis of comprehensive spectroscopic analysis, and the absolute configuration of taxodikaloid A (1) was further confirmed by single-crystal X-ray diffraction. Both structures feature an unprecedented oxazoline ring linkage connecting two abietane diterpenoid monomers. A plausible biosynthetic pathway for compounds 1 and 2 is proposed. Both compounds show potential neuroprotective activity against Aβ25-35-induced damage in SH-SY5Y cells.
authors.affiliation: University of Chinese Academy of Sciences , No. 19A Yuquan Road, Beijing 100049, China.
authors.forename: Xing-Hao
authors.initials: XH
authors.lastname: Huang
authors.forename: Ling-Xue
authors.initials: LX
authors.lastname: Tao
authors.forename: Chang-Qiang
authors.initials: CQ
authors.lastname: Ke
authors.forename: Chunping
authors.initials: C
authors.lastname: Tang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, ShanghaiTech University , Shanghai 201203, China.
authors.forename: Yang
authors.identifier: 0000-0003-1316-5915
authors.initials: Y
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macau, China.
authors.forename: Li-Gen
authors.initials: LG
authors.lastname: Lin
authors.forename: Sheng
authors.initials: S
authors.lastname: Yao
mesh_terms: D045784:Abietanes; D004224:Diterpenes; D015394:Molecular Structure; D032489:Taxodium / Q000737:chemistry*
chemical_list: D045784:Abietanes; D004224:Diterpenes