title: Diagnosis, classification, and therapeutic interventions for sinopulmonary Aspergillosis.
abstract: Sinopulmonary aspergillosis represents a diverse collection of allergic, invasive, and chronic sinus and respiratory conditions. These diseases can affect patients with and without immune impairment and in some cases may be life-threatening. Areas covered: We review the diagnosis, classification, and therapeutic options available to treat sinopulmonary aspergillosis and look ahead to emerging diagnostic and therapeutic options that may soon play an important role in clinical practice. Expert commentary: Histopathology and tissue culture remain the gold standard for the diagnosis of invasive sinopulmonary aspergillosis, but several new molecular detection methods have recently emerged, including various PCR-based platforms, MALDI-TOF, and lateral flow assays. We examine these methodologies as well as the barriers associated with the standardization, validation, and implementation. We also explore the pipeline of antifungal agents in development to treat sinopulmonary aspergillosis.
authors.affiliation: a Hospital Medicine , Joan and Sanford I Weill Medical College of Cornell University Ringgold standard institution , New York , NY , USA.
authors.forename: Matthew William
authors.initials: MW
authors.lastname: McCarthy
authors.affiliation: b Transplantation-Oncology Infectious Diseases Program , Weill Cornell Medical Center of Cornell University , New York , NY , USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Aguilar-Zapata
authors.affiliation: b Transplantation-Oncology Infectious Diseases Program , Weill Cornell Medical Center of Cornell University , New York , NY , USA.
authors.forename: Vidmantas
authors.initials: V
authors.lastname: Petraitis
authors.affiliation: c Transplantation-Oncology Infectious Diseases Program , Weill Cornell Medical Center , New York , NY , USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D006801:Humans; D055732:Pulmonary Aspergillosis / Q000145:classification / Q000175:diagnosis* / Q000628:therapy*; D012852:Sinusitis / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*
chemical_list: D000935:Antifungal Agents
keywords: PCR; allergic bronchopulmonary aspergillosis; isavuconazole; lateral flow assay; magnetic resonance; voriconazole