title: Development and characterization of morin hydrate loaded microemulsion for the management of Alzheimer's disease.
abstract: The aim of this study is to prepare and characterize intranasal delivery of morin hydrate loaded microemulsion for the management of Alzheimer's diseases. After intranasal delivery, brain and blood drug concentrations were found to be higher for optimized morin hydrate loaded microemulsion as compared to plain morin hydrate. Significant (P < 0.05) reduction in assessed pharmacodynamic parameters was observed after intranasal administration of morin hydrate loaded microemulsion as compared to sham control group. Daily chronic treatment with morin loaded microemulsion till the 21st day significantly increased the memory in wistar rats with STZ-induced dementia.
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Sharma
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Manpreet
authors.initials: M
authors.lastname: Singh
authors.affiliation: b Department of Pharmacology , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Punnet
authors.initials: P
authors.lastname: Kumar
authors.affiliation: c Head, Pharmacy , DMCH , Ludhiana , India.
authors.forename: Vir
authors.initials: V
authors.lastname: Vikram
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
mesh_terms: D000281:Administration, Intranasal; D000544:Alzheimer Disease / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004655:Emulsions; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D009821:Oils / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D047309:Flavones
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D005419:Flavonoids; D009821:Oils; D013501:Surface-Active Agents; C008548:morin; D047309:Flavones
keywords: Neurofibrillary tangles; amyloid β-peptide; blood–brain barrier; microemulsion; surfactant and cosurfactant ratio (Smix)