title: A highly sensitive SERS-based platform for Zn(ii) detection in cellular media.
abstract: We report a highly sensitive and selective surface-enhanced Raman scattering (SERS)-based detection of aqueous Zn(ii) ions (limit of detection 10-14M). Spectral changes for a silver nanoparticle-bound Raman reporter upon Zn(ii) chelation constitutes the assay, which is applied to drinking water and to measurements of cellular uptake of Zn(ii).
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. limin@ihep.ac.cn yaozy@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. limin@ihep.ac.cn yaozy@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. limin@ihep.ac.cn yaozy@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Xiangchun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: ISIS & icFRC, University of Strasbourg and CNRS, 8 allée Gaspard Monge, 67000 Strasbourg, France and School of Chemistry and Bio21 Institute, University of Melbourne, Victoria 3010, Australia.
authors.forename: James A
authors.initials: JA
authors.lastname: Hutchison
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. limin@ihep.ac.cn yaozy@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Zhu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. limin@ihep.ac.cn yaozy@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Zhiyi
authors.identifier: http://orcid.org/0000-0003-2322-8166
authors.initials: Z
authors.lastname: Yao
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. limin@ihep.ac.cn yaozy@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. limin@ihep.ac.cn yaozy@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Min
authors.identifier: http://orcid.org/0000-0003-2959-9080
authors.initials: M
authors.lastname: Li
mesh_terms: D003470:Culture Media / Q000737:chemistry* / Q000378:metabolism; D060766:Drinking Water / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D015032:Zinc / Q000032:analysis* / Q000378:metabolism
chemical_list: D003470:Culture Media; D060766:Drinking Water; D012834:Silver; D015032:Zinc