title: CD36 gene polymorphism is associated with Alzheimer's disease.
abstract: CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
authors.affiliation: Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia. Electronic address: omarsery@sci.muni.cz.
authors.forename: Omar
authors.initials: O
authors.lastname: Šerý
authors.affiliation: Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.
authors.forename: Jana
authors.initials: J
authors.lastname: Janoutová
authors.affiliation: Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.
authors.forename: Laura
authors.initials: L
authors.lastname: Ewerlingová
authors.affiliation: Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.
authors.forename: Alice
authors.initials: A
authors.lastname: Hálová
authors.affiliation: Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia.
authors.forename: Jan
authors.initials: J
authors.lastname: Lochman
authors.affiliation: Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Janout
authors.affiliation: Physiologie de la Nutrition et Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, 6, Boulevard Gabriel, Dijon, 21000, France.
authors.forename: Naim A
authors.initials: NA
authors.lastname: Khan
authors.affiliation: Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia; Discipline Anatomy and Histology and Bosch Institute, School of Medical Sciences, Sydney Medical School, The University of Sydney, NSW, 2006, Australia.
authors.forename: Vladimir J
authors.initials: VJ
authors.lastname: Balcar
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D018955:CD36 Antigens / Q000235:genetics*; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D018955:CD36 Antigens; D002784:Cholesterol
keywords: ApoE; Association; CD36; Gene; MMSE; Polymorphism