title: Computed Tomography in Cystic Fibrosis: Combining Low-Dose Techniques and Iterative Reconstruction.
abstract: OBJECTIVE
  The aim of the study was to evaluate the impact of iterative reconstruction (IR) and low-kilovolt technique on dose reduction and image quality of chest computed tomography scans obtained in patients with cystic fibrosis (CF).
  
  
  METHODS
  A total of 124 CF patients were examined; group A (n = 63) was examined with a dose reduction protocol using IR and group B (n = 61) with a standard protocol using filtered back projection. Further subgroups with tube voltage modulations were established. Quantitative and qualitative image quality was assessed.
  
  
  RESULTS
  The radiation dose in groups with comparable image quality was approximately 40% lower using IR compared with filtered back projection. The IR protocol combined with 80-kV tube voltage showed adequate image quality with a mean effective dose of only 0.47 mSv.
  
  
  CONCLUSIONS
  Iterative reconstruction helps extensively reduce radiation dose by improving image quality. It permits the use of low-kilovolt protocols without significantly degrading image reading ability in the monitoring of the predominantly young patients with CF.
authors.affiliation: From the Departments of *Radiology, and †Radiation Oncology and Radiotheraphy Charité - Universitätsmedizin Berlin, Berlin; ‡Department of Radiology, University of Jena, Jena; and §Department of Pediatrics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Kahn
authors.forename: David
authors.initials: D
authors.lastname: Kaul
authors.forename: Ulrich
authors.initials: U
authors.lastname: Grupp
authors.forename: Georg
authors.initials: G
authors.lastname: Böning
authors.forename: Diane
authors.initials: D
authors.lastname: Renz
authors.forename: Doris
authors.initials: D
authors.lastname: Staab
authors.forename: Vera
authors.initials: V
authors.lastname: Schreiter
authors.forename: Florian
authors.initials: F
authors.lastname: Streitparth
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D011829:Radiation Dosage; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult