title: Development of patient-specific phantoms for verification of stereotactic body radiation therapy planning in patients with metallic screw fixation.
abstract: A new technique for manufacturing a patient-specific dosimetric phantom using three-dimensional printing (PSDP_3DP) was developed, and its geometrical and dosimetric accuracy was analyzed. External body contours and structures of the spine and metallic fixation screws (MFS) were delineated from CT images of a patient with MFS who underwent stereotactic body radiation therapy for spine metastasis. Contours were converted into a STereoLithography file format using in-house program. A hollow, four-section PSDP was designed and manufactured using three types of 3DP to allow filling with a muscle-equivalent liquid and insertion of dosimeters. To evaluate the geometrical accuracy of PSDP_3DP, CT images were obtained and compared with patient CT data for volume, mean density, and Dice similarity coefficient for contours. The dose distribution in the PSDP_3DP was calculated by applying the same beam parameters as for the patient, and the dosimetric characteristics of the PSDP_3DP were compared with the patient plan. The registered CT of the PSDP_3DP was well matched with that of the real patient CT in the axial, coronal, and sagittal planes. The physical accuracy and dosimetric characteristics of PSDP_3DP were comparable to those of a real patient. The ability to manufacture a PSDP representing an extreme patient condition was demonstrated.
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Dongryul
authors.initials: D
authors.lastname: Oh
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Chae-Seon
authors.initials: CS
authors.lastname: Hong
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Sang Gyu
authors.initials: SG
authors.lastname: Ju
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Minkyu
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Bum Yong
authors.initials: BY
authors.lastname: Koo
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: SungBack
authors.initials: S
authors.lastname: Choi
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Hee Chul
authors.initials: HC
authors.lastname: Park
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Doo Ho
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Department of Radiation Oncology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
authors.forename: Hongryull
authors.initials: H
authors.lastname: Pyo
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D001863:Bone Screws; D006801:Humans; D019047:Phantoms, Imaging; D066330:Printing, Three-Dimensional; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D013131:Spine / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed