title: Applications of chemogenomic library screening in drug discovery.
abstract: The allure of phenotypic screening, combined with the industry preference for target-based approaches, has prompted the development of innovative chemical biology technologies that facilitate the identification of new therapeutic targets for accelerated drug discovery. A chemogenomic library is a collection of selective small-molecule pharmacological agents, and a hit from such a set in a phenotypic screen suggests that the annotated target or targets of that pharmacological agent may be involved in perturbing the observable phenotype. In this Review, we describe opportunities for chemogenomic screening to considerably expedite the conversion of phenotypic screening projects into target-based drug discovery approaches. Other applications are explored, including drug repositioning, predictive toxicology and the discovery of novel pharmacological modalities.
authors.affiliation: Medicine Design, Pfizer, 610 Main Street, Cambridge, Massachusetts 02139, USA.
authors.forename: Lyn H
authors.initials: LH
authors.lastname: Jones
authors.affiliation: Medicine Design, Pfizer, 610 Main Street, Cambridge, Massachusetts 02139, USA.|Present address: Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Bunnage
mesh_terms: D000818:Animals; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D058492:Drug Repositioning / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D010641:Phenotype; D054852:Small Molecule Libraries / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D054852:Small Molecule Libraries