title: Characterization of inclusion complexes of organic ions with hydrophilic hosts by ion transfer voltammetry with solvent polymeric membranes.
abstract: The quantitative characterization of inclusion complexes formed in aqueous phase between organic ions and hydrophilic hosts by ion-transfer voltammetry with solvent polymeric membrane ion sensors is studied, both in a theoretical and experimental way. Simple analytical solutions are presented for the determination of the binding constant of the complex from the variation with the host concentration of the electrochemical signal. These solutions are valid for any voltammetric technique and for solvent polymeric membrane ion sensors comprising one polarisable interface (1PI) and also, for the first time, two polarisable interfaces (2PIs). Suitable experimental conditions and data analysis procedures are discussed and applied to the study of the interactions of a common ionic liquid cation (1-octyl-3-metyl-imidazolium) and an ionisable drug (clomipramine) with two hydrophilic cyclodextrins: α-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. The experimental study is performed via square wave voltammetry with 2PIs and 1PI solvent polymeric membranes and in both cases the electrochemical experiments enable the detection of inclusion complexes and the determination of the corresponding binding constant.
authors.affiliation: Departamento de Química Física, Facultad de Química, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, 30100 Murcia, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Olmos
authors.affiliation: Departamento de Química Física, Facultad de Química, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, 30100 Murcia, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Laborda
authors.affiliation: Departamento de Química Analítica, Facultad de Química, Universidad de Murcia, 30100 Murcia, Spain.
authors.forename: Joaquín Ángel
authors.initials: JÁ
authors.lastname: Ortuño
authors.affiliation: Departamento de Química Física, Facultad de Química, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, 30100 Murcia, Spain. Electronic address: amolina@um.es.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Molina
keywords: Analytical solution; Cyclodextrins; Inclusion complexes; Ion-transfer voltammetry; Organic ions; Solvent polymeric membranes