title: Early Motor Fluctuations in a Patient with Striatonigral Degeneration.
abstract: We report a 44-year-old female with striatonigral degeneration (SND) who showed wearing-off oscillations after 4 months of levodopa treatment. The patient presented with asymmetric left-side dominant rigidity, and levodopa was effective at first. However, she began to show wearing-off oscillations of motor symptoms, which gradually worsened thereafter. Fluid-attenuated inversion recovery sequence magnetic resonance imaging (MRI) showed linear lateral putamen hyperintensities, and positron emission tomography (PET) studies using18F-fluorodopa (FD) and11C-N-methylspiperon (NMSP) showed a marked decrease of radioactivity in the right putamen, especially in the posterior putamen. The results of MRI and 2 PET studies with FD and NMSP were well consistent with the diagnosis of SND.
authors.affiliation: Department of Neurology, Tokai University Oiso Hospital, Oiso, Japan.
authors.forename: Fumihito
authors.initials: F
authors.lastname: Yoshii
authors.affiliation: Department of Neurology, Tokai University Oiso Hospital, Oiso, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Moriya
authors.affiliation: Department of Neurology, Tokai University Oiso Hospital, Oiso, Japan.
authors.forename: Tomohide
authors.initials: T
authors.lastname: Ohnuki
authors.affiliation: Department of Neurology, Tokai University Oiso Hospital, Oiso, Japan.
authors.forename: Wakoh
authors.initials: W
authors.lastname: Takahashi
authors.affiliation: Department of Neurology, Tokai University Oiso Hospital, Oiso, Japan.
authors.forename: Masafuchi
authors.initials: M
authors.lastname: Ryo
keywords: Magnetic resonance imaging; Motor fluctuations; Positron emission tomography; Striatonigral degeneration