title: Targeting of herbal bioactives through folate receptors: a novel concept to enhance intracellular drug delivery in cancer therapy.
abstract: Targeted drug delivery through folate receptor (FR) has emerged as a most biocompatible, target oriented, and non-immunogenic cargoes for the delivery of anticancer drugs. FRs are highly overexpressed in many tumor cells (like ovarian, lung, breast, kidney, brain, endometrial, and colon cancer), and targeting them through conjugates bearing specific ligand with encapsulated nanodrug moiety is undoubtedly, a promising approach toward tumor targeting. Folate, being an endogenous ligand, can be exploited well to affect various cellular events occurring during the progress of tumor, in a more natural and definite way. Thus, the aim of the review lies in summarizing the advancements taken place in the drug delivery system of different therapeutics through FRs and to refine its role as an endogenous ligand, in targeting of synthetic as well as natural bioactives. The review also provides an update on the patents received on the folate-based drug delivery system.
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Anshita
authors.initials: A
authors.lastname: Gupta
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Chanchal Deep
authors.initials: CD
authors.lastname: Kaur
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Shailendra
authors.initials: S
authors.lastname: Saraf
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Swarnlata
authors.initials: S
authors.lastname: Saraf
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D058975:Folate Receptor 1 / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D005492:Folic Acid / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008024:Ligands; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry; D011956:Receptors, Cell Surface
chemical_list: D000970:Antineoplastic Agents; D058975:Folate Receptor 1; D008024:Ligands; D011956:Receptors, Cell Surface; D005492:Folic Acid
keywords: cancer; cargoes; conjugate; folate; targeted drug delivery