title: Altered motion repulsion in Alzheimer's disease.
abstract: Recent research in Alzheimer's disease (AD) indicates that perceptual impairments may occur before the onset of cognitive declines, and can thus serve as an early noninvasive indicator for AD. In this study, we focused on visual motion processing and explored whether AD induces changes in the properties of direction repulsion between two competing motions. We used random dot kinematograms (RDKs) and measured the magnitudes of direction repulsion between two overlapping RDKs moving different directions in three groups of participants: an AD group, an age-matched old control group, and a young control group. We showed that motion direction repulsion was significantly weaker in AD patients as comparing to both healthy controls. More importantly, we found that the magnitude of motion repulsion was predictive of the assessment of clinical severity in the AD group. Our results implicate that AD pathology is associated with altered neural functions in visual cortical areas and that motion repulsion deficit is a behavioral biomarker for the tracking of AD development.
authors.affiliation: Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang City, 471000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan City, 250021, China.
authors.forename: Shougang
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan City, 250021, China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First People's Hospital of Jinan City, Shandong Province, 250011, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009039:Motion Perception; D014793:Visual Cortex / Q000503:physiopathology*; D014796:Visual Perception; D055815:Young Adult