title: Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography.
abstract: In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy ofin situporcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young's modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young's modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties.
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA; Contributed equally to the present work.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Singh
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA; Contributed equally to the present work.
authors.forename: Jiasong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Zhaolong
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Raksha
authors.initials: R
authors.lastname: Raghunathan
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Achuth
authors.initials: A
authors.lastname: Nair
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Salavat
authors.initials: S
authors.lastname: Aglyamov
authors.affiliation: School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Twa
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA; Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, Russia; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030 USA.
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Larin
keywords: (170.4460) Ophthalmic optics and devices; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography; (170.6935) Tissue characterization