title: Right Ventricular Structure and Function Are Associated With Incident Atrial Fibrillation: MESA-RV Study (Multi-Ethnic Study of Atherosclerosis-Right Ventricle).
abstract: Right ventricular (RV) morphology has been associated with drivers of atrial fibrillation (AF) risk, including left ventricular and pulmonary pathology, systemic inflammation, and neurohormonal activation. The aim of this study was to investigate the association between RV morphology and risk of incident AF.
  
  
  
  We interpreted cardiac magnetic resonance imaging in 4204 participants free of clinical cardiovascular disease in the MESA (Multi-Ethnic Study of Atherosclerosis). Incident AF was determined using hospital discharge records, study electrocardiograms, and Medicare claims data. The study sample (n=3819) was 61±10 years old and 47% male with 47.2% current/former smokers. After adjustment for demographics and clinical factors, including incident heart failure, higher RV ejection fraction (hazard ratio, 1.16 per SD; 95% confidence interval, 1.03-1.32; P=0.02) and greater RV mass (hazard ratio, 1.25 per SD; 95% confidence interval, 1.08-1.44; P=0.002) were significantly associated with incident AF. After additional adjustment for the respective left ventricular parameter, higher RV ejection fraction remained significantly associated with incident AF (hazard ratio, 1.15 per SD; 95% confidence interval, 1.01-1.32; P=0.04), whereas the association was attenuated for RV mass (hazard ratio, 1.16 per SD; 95% confidence interval, 0.99-1.35; P=0.07). In a subset of patients with available spirometry (n=2540), higher RV ejection fraction and mass remained significantly associated with incident AF after additional adjustment for lung function (P=0.02 for both).
  
  
  
  Higher RV ejection fraction and greater RV mass were associated with an increased risk of AF in a multiethnic population free of clinical cardiovascular disease at baseline.
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Neal A
authors.initials: NA
authors.lastname: Chatterjee
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Ravi V
authors.initials: RV
authors.lastname: Shah
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Venkatesh L
authors.initials: VL
authors.lastname: Murthy
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Amy
authors.initials: A
authors.lastname: Praestgaard
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Sanjiv J
authors.initials: SJ
authors.lastname: Shah
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Corey E
authors.initials: CE
authors.lastname: Ventetuolo
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Richard
authors.initials: R
authors.lastname: Kronmal
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Joao A C
authors.initials: JA
authors.lastname: Lima
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Michael
authors.initials: M
authors.lastname: Jerosch-Herold
authors.affiliation: For the author affiliations, please see the Appendix.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Alonso
authors.affiliation: For the author affiliations, please see the Appendix. kawut@upenn.edu.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Kawut
mesh_terms: D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000208:ethnology / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000208:ethnology / Q000503:physiopathology*
keywords: atrial fibrillation; heart failure; heart ventricles; magnetic resonance imaging