title: Chlorogenic acid rescues sensorineural auditory function in a diabetic animal model.
abstract: Recently, many studies have reported that sensorineural hearing impairment related to neurological disorders may be caused by diabetes mellitus. However, to date, only a small number of studies have investigated the treatment of sensorineural hearing impairment. In the present study, the effects of chlorogenic acid on diabetic auditory pathway impairment were evaluated by neuro-electrical physiological measurements and morphological investigations. We have shown that CA efficiently prevents the progression of auditory pathway dysfunction caused by DM using auditory brainstem responses and auditory middle latency responses in mice. Additionally, using transient-evoked otoacoustic emissions measurement and scanning electron microscope observation of hair cells in DM mice, we found that CA may aid in the recovery from outer hair cell and otic hair cell damage. In conclusion, CA has beneficial effects for the management of diabetic sensorineural auditory dysfunction.
authors.affiliation: College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea; Department of Audiology, Nambu University, Gwangju 506-706, Republic of Korea.
authors.forename: Bin Na
authors.initials: BN
authors.lastname: Hong
authors.affiliation: College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea; Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 446-701, Republic of Korea.
authors.forename: Youn Hee
authors.initials: YH
authors.lastname: Nam
authors.affiliation: College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea; Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 446-701, Republic of Korea.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Woo
authors.affiliation: College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea; Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 446-701, Republic of Korea. Electronic address: panjae@khu.ac.kr.
authors.forename: Tong Ho
authors.initials: TH
authors.lastname: Kang
mesh_terms: D000496:Alloxan; D000818:Animals; D017209:Apoptosis; D001306:Auditory Pathways / Q000187:drug effects / Q000503:physiopathology; D002726:Chlorogenic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D003056:Cochlear Nerve / Q000187:drug effects / Q000503:physiopathology; D048909:Diabetes Complications / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007814:Larva / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D015027:Zebrafish
chemical_list: D007004:Hypoglycemic Agents; D002726:Chlorogenic Acid; D000496:Alloxan
keywords: Chlorogenic acid; Diabetic mellitus; Mice; Sensorineural auditory function