title: Plasma phospholipid changes are associated with response to chemotherapy in non-Hodgkin lymphoma patients.
abstract: Limited studies have been performed to associate abnormal phospholipid (PL) profile and disease activity in hematological malignancies, including non-Hodgkin lymphoma (NHL). The aim of his study was to evaluate the levels of plasma PL fractions in NHL patients, in response to chemotherapy. Forty non-treated patients with NHL and 25 healthy individuals were recruited. Blood samples from patients were taken before chemotherapy, after 3 cycles and after the end of the treatment, and PL fractions were resolved by one-dimensional thin-layer chromatography. To assess potential relationship between plasma PL profile and response to therapy, patients were divided according to clinical outcome in 3 groups: complete remission (CR), stable disease (SD) and progression (PG). Despite significant differences between NHL patients and healthy controls, no differences were found at baseline among patients divided according to clinical outcome. During and after chemotherapy important alterations in PL profile were observed. Levels of total PLs and all PL fractions decreased in patients with PG while in patients who responded to therapy (CR, SD) PLs significantly increased. Results of our study suggest that changes of total PLs and PL fractions during the therapy are associated with the effects of therapy and clinical outcome in patients with NHL.
authors.affiliation: Department of Hematology, Clinical Hospital Center Zemun, Vukova 9, 11080 Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Dr Subotića 8, 11000 Belgrade, Serbia.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Cvetković
authors.affiliation: Department of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, 11000 Belgrade, Serbia. Electronic address: mmilosevic@vin.bg.ac.rs.
authors.forename: Maja
authors.initials: M
authors.lastname: Milošević
authors.affiliation: Department of Urology, Clinical Hospital Center Zemun, Vukova 9, 11080 Belgrade, Serbia.
authors.forename: Bora
authors.initials: B
authors.lastname: Cvetković
authors.affiliation: Department of Physical Chemistry, Vinca Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, 11000 Belgrade, Serbia.
authors.forename: Romana
authors.initials: R
authors.lastname: Masnikosa
authors.affiliation: Institute for Medical Research, Department for Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, 11129 Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Arsić
authors.affiliation: Institute for Medical Research, Department for Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, 11129 Belgrade, Serbia.
authors.forename: Snježana
authors.initials: S
authors.lastname: Petrović
authors.affiliation: Institute for Medical Research, Department for Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, 11129 Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Vučić
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D010743:Phospholipids
keywords: Chemotherapy; Non-Hodgkin lymphoma; Plasma phospholipid profile