title: Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity.
abstract: An efficient synthesis of ergot alkaloid lysergol and its analogues is described, providing compounds for functional evaluation at the human 5-HT1A, 5-HT2A, 5-HT2B, or 5-HT2Creceptors. Key features of the synthesis include the development of a tandem reaction to construct the multifunctionalized piperidine skeleton and use of a rhodium-catalyzed [3 + 2] annulation in the late-stage indole formation.
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, and ‡Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871, China.
authors.forename: Haosen
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, and ‡Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871, China.
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, and ‡Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871, China.
authors.forename: Tuoping
authors.identifier: 0000-0003-2156-3198
authors.initials: T
authors.lastname: Luo
mesh_terms: D004873:Ergolines / Q000138:chemical synthesis*; D015394:Molecular Structure; D011985:Receptors, Serotonin
chemical_list: D004873:Ergolines; D011985:Receptors, Serotonin; C061884:lysergol