title: The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis.
abstract: BACKGROUND
  Genetic factors play an important role in the pathogenesis of coronary heart disease (CHD). Kinesin-like protein 6 (KIF6) is a new candidate gene for CHD, since it has been identified as a potential risk factor. The aim of this study was to perform a systematic review and meta-analysis of previously published association studies between the Trp719Arg polymorphism of KIF6 and the development of CHD.
  
  
  METHODS
  Studies and abstracts investigating the relationship between the Trp719Arg polymorphism of KIF6 and subsequent risk for development of CHD were reviewed. Electronic search from Pubmed and EBSCO databases was performed between 1993 and 2014 to identify studies that fulfilled the inclusion criteria. To analyze the association we used the models: allelic, additive, dominant and recessive. Moreover, we conducted a sub-analysis by populations using the same four models.
  
  
  RESULTS
  Twenty-three studies were included in the meta-analysis. The Trp719Arg polymorphism showed a significant association with CHD when the analysis comprised the population with myocardial infarction (MI) and the additive genetic model was used. Moreover, this polymorphism showed a protective association with CHD when the analysis comprised the whole population using the recessive genetic model.
  
  
  CONCLUSIONS
  Our findings indicate that the Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing MI and that allele 719Arg may have a protective association to present CHD in all populations.
  CRD42015024602.
authors.affiliation: División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Ruiz-Ramos
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km. 1, Col. La Esmeralda, C.P. 86690 Cunduacán, Tabasco Mexico.
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Hernández-Díaz
authors.affiliation: División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco Mexico.
authors.forename: Carlos Alfonso
authors.initials: CA
authors.lastname: Tovilla-Zárate
authors.affiliation: División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco Mexico.
authors.forename: Isela
authors.initials: I
authors.lastname: Juárez-Rojop
authors.affiliation: Hospital General de Yajalón. Secretaría de Salud, Yajalón, Chiapas Mexico.
authors.forename: María Lilia
authors.initials: ML
authors.lastname: López-Narváez
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km. 1, Col. La Esmeralda, C.P. 86690 Cunduacán, Tabasco Mexico.
authors.forename: Thelma Beatriz
authors.initials: TB
authors.lastname: González-Castro
authors.affiliation: Hospital de Alta Especialidad "Juan Graham Casasús", Villahermosa, Tabasco Mexico.
authors.forename: Manuel Eduardo
authors.initials: ME
authors.lastname: Torres-Hernández
authors.affiliation: Hospital de Alta Especialidad "Juan Graham Casasús", Villahermosa, Tabasco Mexico.
authors.forename: Manuel Alfonso
authors.initials: MA
authors.lastname: Baños-González
mesh_terms: D000483:Alleles; D003327:Coronary Disease / Q000235:genetics*; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People
chemical_list: C526774:KIF6 protein, human; D016547:Kinesins
keywords: Cardiovascular disease; KIF6; Meta-analysis; Systematic review; Trp719Arg polymorphism