title: Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs.
abstract: Maropitant, a neurokinin-1 receptor antagonist, may provide analgesic effects by blocking pharmacological action of substance P. Carprofen is a non-steroidal anti-inflammatory drug commonly used for pain control in dogs. The purpose of this study was to evaluate the effect of a combination of maropitant and carprofen on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Six healthy adult beagle dogs were anesthetized with sevoflurane four times with a minimum of 7-day washout period. On each occasion, maropitant (1 mg/kg) alone, carprofen (4 mg/kg) alone, a combination of maropitant (1 mg/kg) and carprofen (4 mg/kg), or saline (0.1 ml/kg) was subcutaneously administered at 1 hr prior to the first electrical stimulation for the sevoflurane MAC-BAR determination. The sevoflurane MAC-BAR was significantly reduced by maropitant alone (2.88 ± 0.73%, P=0.010), carprofen alone (2.96 ± 0.38%, P=0.016) and the combination (2.81 ± 0.51%, P=0.0003), compared with saline (3.37 ± 0.56%). There was no significant difference in the percentage of MAC-BAR reductions between maropitant alone, carprofen alone and the combination. The administration of maropitant alone and carprofen alone produced clinically significant sparing effects on the sevoflurane MAC-BAR in dogs. However, the combination of maropitant and carprofen did not produce any additive effect on the sevoflurane MAC-BAR reduction. Anesthetic premedication with a combination of maropitant and carprofen may not provide any further sparing effect on anesthetic requirement in dogs.
authors.affiliation: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8591, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Fukui
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ooyama
authors.forename: Jun
authors.initials: J
authors.lastname: Tamura
authors.forename: Mohammed Ahmed
authors.initials: MA
authors.lastname: Umar
authors.forename: Tomohito
authors.initials: T
authors.lastname: Ishizuka
authors.forename: Takaharu
authors.initials: T
authors.lastname: Itami
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sano
authors.forename: Kazuto
authors.initials: K
authors.lastname: Yamashita
mesh_terms: D000758:Anesthesia / Q000662:veterinary; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D002227:Carbazoles / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D064729:Neurokinin-1 Receptor Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D011292:Premedication; D011650:Pulmonary Alveoli / Q000187:drug effects*; D011812:Quinuclidines / Q000008:administration & dosage / Q000494:pharmacology*; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D008738:Methyl Ethers; D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines; D000077149:Sevoflurane; C518176:maropitant; C007005:carprofen