title: Putting the brakes on transcription at damaged chromatin: Do Polycomb silencers do more than modify histones?
abstract: One of the cellular responses to DNA damage is to monitor and execute temporary arrest of RNA synthesis at chromatin lesions. The Polycomb silencer BMI1 is a well-known contributor to this process. We recently described a new mode of BMI1-mediated transcription arrest at lesions that involves UBR5 E3 ligase and FACT histone chaperon.
authors.affiliation: Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida , Tampa, FL, USA.
authors.forename: Younghoon
authors.initials: Y
authors.lastname: Kee
keywords: BMI1; FACT; Polycomb