title: Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms.
abstract: Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis byHelicobacter pylori.Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize thatH. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells.
authors.affiliation: Department of Medical Oncology.
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Villa Guzmán
authors.affiliation: Department of Medical Oncology.
authors.forename: J
authors.initials: J
authors.lastname: Espinosa
authors.affiliation: Department of Medical Oncology.
authors.forename: R
authors.initials: R
authors.lastname: Cervera
authors.affiliation: Department of Pathology.
authors.forename: M
authors.initials: M
authors.lastname: Delgado
authors.affiliation: Department of Gastroenterology.
authors.forename: R
authors.initials: R
authors.lastname: Patón
authors.affiliation: Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Cordero García
keywords: H. pylori; chemokines; gastrointestinal metastases; lobular carcinoma