title: The endoplasmic reticulum-mitochondria coupling in health and disease: Molecules, functions and significance.
abstract: The close apposition between endoplasmic reticulum (ER) and mitochondria represents a key platform, capable to regulate different fundamental cellular pathways. Among these, Ca2+signaling and lipid homeostasis have been demonstrated over the last years to be deeply modulated by ER-mitochondria cross-talk. Given its importance in cell life/death decisions, increasing evidence suggests that alterations of the ER-mitochondria axis could be responsible for the onset and progression of several diseases, including neurodegeneration, cancer and obesity. However, the molecular identity of the proteins controlling this inter-organelle apposition is still debated. In this review, we summarize the main cellular pathways controlled by ER-mitochondria appositions, focusing on the principal molecules reported to be involved in this interplay and on those diseases for which alterations in organelles communication have been reported.
authors.affiliation: Department of Biomedical Sciences, University of Padova, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Filadi
authors.affiliation: Department of Biomedical Sciences, University of Padova, Italy.
authors.forename: Pierre
authors.initials: P
authors.lastname: Theurey
authors.affiliation: Department of Biomedical Sciences, University of Padova, Italy; Neuroscience Institute, National Research Council (CNR), Padova, Italy. Electronic address: paola.pizzo@unipd.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Pizzo
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism
chemical_list: D002118:Calcium
keywords: Calcium (Ca(2+)); ER-mitochondria tethering; Endoplasmic reticulum (ER); Inter-organelle contacts; Mitochondria; Mitochondria-Associated Membranes (MAMs); Mitofusin 2