title: Serum procalcitonin correlates with colonoscopy findings and can guide therapeutic decisions in postoperative ischemic colitis.
abstract: BACKGROUND
  Postoperative ischaemic colitis (POIC) is a life-threatening vascular gastrointestinal condition. Serum procalcitonin (PCT) levels be of value in the detection of necrosis.
  
  
  OBJECTIVE
  To evaluate the correlation between serum PCT levels and the colonoscopic assessment of the severity of POIC.
  
  
  METHODS
  Between January 2007 and November 2014, 150 patients with POIC and PCT data were included in the study. The main outcome measure was the correlation between serum PCT and the colonoscopy-based assessment of the severity of POIC (according to Favier's classification: stage 1/2 without multi-organ failure vs. stage 2/3 with multi-organ failure).
  
  
  RESULTS
  Eighty-five percent of the stage 1 cases (n=22) had a serum PCT level ≤2μg/L; 63% (n=19) of the stage 2 cases with multi-organ failure had a PCT level between 4 and 8μg/L, and 70% (n=52) of the stage 3 cases had a PCT level ≥8μg/L. The PCT level was strongly correlated with the Favier stage (Spearman's rho: 0.701; p<0.0001). PCT levels were similar in stage 2 cases with multi-organ failure and in stage 3 cases (16.06μg/L vs. 7.79μg/L, respectively; p=0.35).
  
  
  CONCLUSIONS
  Serum PCT is correlated with stage 2/3 POIC requiring surgery. If PCT ≥5μg/L, surgery should be considered.
authors.affiliation: Department of Digestive and Oncological Surgery, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France; INSERM U1088, Jules Verne University of Picardie, Amiens, France; Clinical Research Centre, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France.
authors.forename: C
authors.initials: C
authors.lastname: Cossé
authors.affiliation: Department of Digestive and Oncological Surgery, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France; INSERM U1088, Jules Verne University of Picardie, Amiens, France.
authors.forename: C
authors.initials: C
authors.lastname: Sabbagh
authors.affiliation: Department of Gastroenterology, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France.
authors.forename: M
authors.initials: M
authors.lastname: Fumery
authors.affiliation: Department of Anaesthesiology and Cardiovascular Intensive Care, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France.
authors.forename: E
authors.initials: E
authors.lastname: Zogheib
authors.affiliation: Department of Visceral Surgery, Beauvais General Hospital, Beauvais, France.
authors.forename: F
authors.initials: F
authors.lastname: Mauvais
authors.affiliation: Department of Visceral Surgery, Beauvais General Hospital, Beauvais, France.
authors.forename: F
authors.initials: F
authors.lastname: Browet
authors.affiliation: Department of Digestive and Oncological Surgery, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France.
authors.forename: L
authors.initials: L
authors.lastname: Rebibo
authors.affiliation: Department of Digestive and Oncological Surgery, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France; Clinical Research Centre, Amiens University Hospital, Jules Verne University of Picardie, Amiens, France; EA4294, Jules Verne University of Picardie, Amiens, France. Electronic address: regimbeau.jean-marc@chu-amiens.fr.
authors.forename: J M
authors.initials: JM
authors.lastname: Regimbeau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D017091:Colitis, Ischemic / Q000097:blood* / Q000150:complications / Q000628:therapy*; D003113:Colonoscopy; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000150:complications; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002116:Calcitonin
keywords: Colonoscopy; Favier stage; Ischaemic damage; Procalcitonin