title: Spongelike Porous Silica Nanosheets: From "Soft" Molecular Trapping to DNA Delivery.
abstract: Spongelike porous silica nanosheets, with nanometer thicknesses and pores whose diameters are on the hundreds-of-nanometers scale, have been used as a novel carrier for molecular immobilization of different guests. Enhanced properties of encapsulation were shown for drug molecules of different dimensions due to "softness" caused by the specific nanometric features of the porous structure. The encapsulating effect of the structure results in sustained and stimuli-responsive release behavior of immobilized guest molecules. By studying the adsorption process of DNA molecules on spongelike porous nanosheets or on solid nanoparticles by use of a quartz crystal microbalance, we show that better elasticity of surfaces of the porous nanosheets over that of solid nanoparticles can improve the immobilization of guest molecules. The coating of porous silica nanosheets onto various substrates was also found to effectively mediate DNA delivery to mammalian cells.
authors.affiliation: Herbert Gleiter Institute of Nanoscience, Nanjing University of Science & Technology , 200 Xiaolingwei, Nanjing 210094, China.
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Ji
authors.affiliation: WPI Center for Materials Nanoarchitectonics, National Institute for Materials Science , 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Yamazaki
authors.affiliation: Herbert Gleiter Institute of Nanoscience, Nanjing University of Science & Technology , 200 Xiaolingwei, Nanjing 210094, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Sun
authors.affiliation: Faculty of Materials Science and Engineering, Warsaw University of Technology , Wołoska 141, Warsaw 02-507, Poland.
authors.forename: Żaneta
authors.initials: Ż
authors.lastname: Górecka
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University . No. 1 Sec. 4 Roosevelt Road, Taipei 10617, Taiwan.
authors.forename: Nien-Chi
authors.initials: NC
authors.lastname: Huang
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University . No. 1 Sec. 4 Roosevelt Road, Taipei 10617, Taiwan.
authors.forename: Shan-Hui
authors.initials: SH
authors.lastname: Hsu
authors.affiliation: WPI Center for Materials Nanoarchitectonics, National Institute for Materials Science , 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Lok Kumar
authors.initials: LK
authors.lastname: Shrestha
authors.affiliation: WPI Center for Materials Nanoarchitectonics, National Institute for Materials Science , 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Hill
authors.affiliation: WPI Center for Materials Nanoarchitectonics, National Institute for Materials Science , 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Ariga
mesh_terms: D000327:Adsorption; D000818:Animals; D004247:DNA; D053758:Nanoparticles; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D012822:Silicon Dioxide; D004247:DNA
keywords: DNA delivery; controlled release; nanosheet; porous; silica