title: Arterial Spin-Labeling to Discriminate Pediatric Cervicofacial Soft-Tissue Vascular Anomalies.
abstract: Differentiating major subtypes of cervicofacial vascular lesions is crucial for appropriate management. The aim of our study was to evaluate the performance of an MR imaging arterial spin-labeling perfusion sequence in discriminating pediatric cervicofacial soft-tissue vascular anomalies.
  
  
  
  We conducted a retrospective analysis of data from a prospectively maintained registry including pediatric patients at a tertiary pediatric center between January 2012 and January 2014. We included pediatric patients with a final diagnosis of soft-tissue vascular anomalies and an MR imaging, including an arterial spin-labeling sequence at presentation. We performed an analysis of lesion perfusion, blinded to clinical data, by using concurrent spiral 3D pseudocontinuous arterial spin-labeling (1.5T magnet; spiral matrix, 512 × 8 mm; postlabeling delay, 1025 ms). Lesional flow was recorded with calibrated intralesional ROIs. Perfusion characteristics were compared among lesion subtypes with the Mood Median test.
  
  
  
  Among 840 patients screened, 46 matched the inclusion criteria and were included (median age, 1.45 years; interquartile range, 0.4-5.1 years; 27 females). Hemangiomas, including infantile hemangiomas (n= 18 patients) and noninvoluting (n= 2) and rapidly involuting (n= 1) congenital types, demonstrated marked hyperperfusion (median flow, 436 mL/min/100 g; interquartile range, 212.5-603 mL/min/100 g), significantly higher than that of lymphatic malformations (median, 22.5 mL/min/100 g; interquartile range, 16-60 mL/min/100 g;P< .001) or venous malformations (median, 25 mL/min/100 g; interquartile range, 15-66.5 mL/min/100 g;P= .003).
  
  
  
  MR imaging arterial spin-labeling is a valuable tool for the assessment of soft-tissue vascular anomaly hemodynamics and for the classification of major lesion subtypes.
authors.affiliation: From the Department of Pediatric Radiology (G.B., V.D.-R., N.B., O.N., F.B.) gregoireboulouis@gmail.com.|Institut National de la Santé et de la Recherche Médicale U894 (G.B., O.N.), Descartes University, Paris, France.|Department of Neuroradiology (G.B., O.N.), Centre Hospitalier Sainte Anne, Paris, France.
authors.forename: G
authors.identifier: 0000-0001-8422-9205
authors.initials: G
authors.lastname: Boulouis
authors.affiliation: From the Department of Pediatric Radiology (G.B., V.D.-R., N.B., O.N., F.B.).|Institut National de la Santé et de la Recherche Médicale U1000 (V.D.-R., N.B., F.B.).
authors.forename: V
authors.identifier: 0000-0003-1260-5886
authors.initials: V
authors.lastname: Dangouloff-Ros
authors.affiliation: Departments of Pediatric Dermatology (O.B.).|Pediatric Oto-Rhino-Laryngology (O.B., N.G., V.C.).|Pediatric Maxillo-Facial and Plastic Surgery (O.B., V.S., A.P., O.N.), Necker Children's Hospital, Descartes University, Paris, France.|Centre de Référence des Malformations Rares de la Face de la Cavite Buccale (O.B., V.S., A.P.), Maxillofacial Malformation Reference Center, Paris, France.|Faculté de Médecine Paris-Descartes (O.B., N.G., V.S., A.P., V.C., N.B., F.B.), Université Paris 5, Paris, France.
authors.forename: O
authors.identifier: 0000-0003-3508-2539
authors.initials: O
authors.lastname: Boccara
authors.affiliation: Pediatric Oto-Rhino-Laryngology (O.B., N.G., V.C.).|Faculté de Médecine Paris-Descartes (O.B., N.G., V.S., A.P., V.C., N.B., F.B.), Université Paris 5, Paris, France.
authors.forename: N
authors.identifier: 0000-0002-4419-2257
authors.initials: N
authors.lastname: Garabedian
authors.affiliation: Pediatric Maxillo-Facial and Plastic Surgery (O.B., V.S., A.P., O.N.), Necker Children's Hospital, Descartes University, Paris, France.|Centre de Référence des Malformations Rares de la Face de la Cavite Buccale (O.B., V.S., A.P.), Maxillofacial Malformation Reference Center, Paris, France.|Faculté de Médecine Paris-Descartes (O.B., N.G., V.S., A.P., V.C., N.B., F.B.), Université Paris 5, Paris, France.
authors.forename: V
authors.identifier: 0000-0001-7206-5442
authors.initials: V
authors.lastname: Soupre
authors.affiliation: Pediatric Maxillo-Facial and Plastic Surgery (O.B., V.S., A.P., O.N.), Necker Children's Hospital, Descartes University, Paris, France.|Centre de Référence des Malformations Rares de la Face de la Cavite Buccale (O.B., V.S., A.P.), Maxillofacial Malformation Reference Center, Paris, France.|Faculté de Médecine Paris-Descartes (O.B., N.G., V.S., A.P., V.C., N.B., F.B.), Université Paris 5, Paris, France.
authors.forename: A
authors.identifier: 0000-0002-9679-6060
authors.initials: A
authors.lastname: Picard
authors.affiliation: Pediatric Oto-Rhino-Laryngology (O.B., N.G., V.C.).|Faculté de Médecine Paris-Descartes (O.B., N.G., V.S., A.P., V.C., N.B., F.B.), Université Paris 5, Paris, France.
authors.forename: V
authors.identifier: 0000-0002-6480-5903
authors.initials: V
authors.lastname: Couloigner
authors.affiliation: From the Department of Pediatric Radiology (G.B., V.D.-R., N.B., O.N., F.B.).|Institut National de la Santé et de la Recherche Médicale U1000 (V.D.-R., N.B., F.B.).|Faculté de Médecine Paris-Descartes (O.B., N.G., V.S., A.P., V.C., N.B., F.B.), Université Paris 5, Paris, France.|Unite Mixte de Recherche 1163 (N.B., F.B.), Institut Imagine, Paris, France.
authors.forename: N
authors.identifier: 0000-0003-0991-7774
authors.initials: N
authors.lastname: Boddaert
authors.affiliation: From the Department of Pediatric Radiology (G.B., V.D.-R., N.B., O.N., F.B.).|Institut National de la Santé et de la Recherche Médicale U894 (G.B., O.N.), Descartes University, Paris, France.|Pediatric Maxillo-Facial and Plastic Surgery (O.B., V.S., A.P., O.N.), Necker Children's Hospital, Descartes University, Paris, France.|Department of Neuroradiology (G.B., O.N.), Centre Hospitalier Sainte Anne, Paris, France.
authors.forename: O
authors.identifier: 0000-0002-9544-379X
authors.initials: O
authors.lastname: Naggara
authors.affiliation: From the Department of Pediatric Radiology (G.B., V.D.-R., N.B., O.N., F.B.).|Institut National de la Santé et de la Recherche Médicale U1000 (V.D.-R., N.B., F.B.).|Faculté de Médecine Paris-Descartes (O.B., N.G., V.S., A.P., V.C., N.B., F.B.), Université Paris 5, Paris, France.|Unite Mixte de Recherche 1163 (N.B., F.B.), Institut Imagine, Paris, France.
authors.forename: F
authors.identifier: 0000-0002-6763-6877
authors.initials: F
authors.lastname: Brunelle
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005145:Face / Q000098:blood supply; D005260:Female; D006391:Hemangioma / Q000151:congenital* / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D008208:Lymphatic System / Q000002:abnormalities; D008279:Magnetic Resonance Imaging; D008297:Male; D012042:Registries; D012189:Retrospective Studies; D013113:Spin Labels; D054079:Vascular Malformations / Q000000981:diagnostic imaging*; D014680:Veins / Q000002:abnormalities / Q000000981:diagnostic imaging; D014711:Vertebral Artery / Q000002:abnormalities / Q000000981:diagnostic imaging
chemical_list: D013113:Spin Labels