title: Comparison of wire-guided localization and radio-guided occult lesionlocalization in preoperative localization of nonpalpable breast lesions.
abstract: OBJECTIVE
  Breast lesions that are not palpable on physical examination but considered suspicious for malignancy on mammography or ultrasonography should be marked before surgery. Wire-guided localization (WGL) is the most frequently used method for preoperative marking of nonpalpable breast lesions (NPBLs). An alternative is marking by a radioactive agent (radio-guided occult lesion localization; ROLL). The present study aimed to compare WGL and ROLL for preoperative marking.
  
  
  METHODS
  The study included 25 patients marked by ROLL and 11 patients marked by WGL. The groups were compared in terms of patient and lesion characteristics, method-related characteristics, hospital stay duration, complications, cosmetic outcomes, and rate of correct marking.
  
  
  RESULTS
  Suspicious lesions were marked with a success rate of 95.6% by ROLL and 100% by WGL. Complications and pain sensation rates were found significantly lower in the ROLL group compared to WGL. Although ROLL was considered more advantageous in terms of hospital stay duration, positive surgical margins, cosmetic outcomes, and excision duration, the differences between the groups were not statistically significant.
  
  
  CONCLUSIONS
  ROLL, which is a simple, comfortable, and reliable method, could be used as an alternative to the WGL in preoperative marking of NPBLs.
authors.affiliation: Department of Nuclear Medicine, Mersin State Hospital, Mersin, Turkey.
authors.forename: Nazım Barış
authors.initials: NB
authors.lastname: Kanat
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Tuncel
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Acıbadem University, İstanbul, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Aksoy
authors.affiliation: Department of Anatomy, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Fırat
authors.affiliation: Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Demirkazık
authors.affiliation: Department of General Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Demirali
authors.initials: D
authors.lastname: Onat
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Çağlar Tuncalı
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Biray Emine
authors.initials: BE
authors.lastname: Caner
mesh_terms: D001940:Breast; D001943:Breast Neoplasms; D006801:Humans; D008327:Mammography; D019275:Radiopharmaceuticals; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals
keywords: Nonpalpable breast lesion; SPECT-CT; radio-guided occult lesion localization; wire-guided localization