title: Relationship of Muscle Mass Determined by DEXA with Spirometric Results in Healthy Individuals.
abstract: BACKGROUND
  Muscle mass maybe a determining factor in the variability of spirometry results in individuals of the same sex and age who have similar anthropometric characteristics. The aim of this study was to determine the association between spirometric results from healthy individuals and their muscle mass assessed by dual energy X-ray absorptiometry (DEXA).
  
  
  METHODS
  A sample of 161 women and 144 men, all healthy non-smokers, was studied. Ages ranged from18 to77years. For each subject, spirometry results and total and regional lean mass values obtained by full body DEXA were recorded. A descriptive analysis of the variables and a regression analysis were performed to study the relationship between spirometric variables and lean body mass, correcting for age and body mass index (BMI).
  
  
  RESULTS
  In both sexes all muscle mass variables correlated positively and significantly with spirometric variables, and to a greater extent in men. After partial adjustment of correlations by age and BMI, the factor which best explains the spirometric variables is the total lean body mass in men, and trunk lean body mass in women.
  
  
  CONCLUSIONS
  In men, muscle mass in the lower extremities is most closely associated with spirometric results. In women, it is the muscle mass of the trunk. In both sexes muscle mass mainly affects FEV1.
authors.affiliation: Departamento de Cirugía y Ciencias Médico Sociales, Unidad docente de Anatomía y Embriología humanas, Facultad de Medicina, Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, España. Electronic address: rafael.martin@uah.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Martín Holguera
authors.affiliation: Departamento de Cirugía y Ciencias Médico Sociales, Unidad docente de Anatomía y Embriología humanas, Facultad de Medicina, Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, España; Departamento de Medicina Interna, Servicio de ESI-Reumatología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Turrión Nieves
authors.affiliation: Departamento de Cirugía y Ciencias Médico Sociales, Unidad docente de Anatomía y Embriología humanas, Facultad de Medicina, Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, España.
authors.forename: Rosa
authors.initials: R
authors.lastname: Rodríguez Torres
authors.affiliation: Departamento de Física y Matemáticas, Unidad docente de Matemáticas, Edificio Politécnico, Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, España.
authors.forename: María Concepción
authors.initials: MC
authors.lastname: Alonso
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000033:anatomy & histology*; D009929:Organ Size; D025341:Principal Component Analysis; D012016:Reference Values; D013147:Spirometry; D013851:Thinness; D055815:Young Adult
keywords: Absorciometría dual fotónica de rayos X; Dual energy X-ray absorptiometry; Espirometría; Fat-free soft tissue mass; Lean body mass; Spirometry; Tejido blando no graso; Tejido magro