title: OBTAIN A: Outcome Benefits of Tranexamic Acid in Hip Arthroplasty. A Randomized Double-Blinded Controlled Trial.
abstract: We examined whether the blood conserving effect of tranexamic acid (TXA) in total hip arthroplasty using the direct anterior approach, translates to an effect on functional outcomes in the perioperative period.
  
  
  
  We conducted a single-center, randomized, double-blinded, placebo-controlled trial. One hundred one patients were randomized to receive either TXA or an equivalent volume of normal saline. The primary outcome measure was thigh swelling. Secondary outcome measures included, visual analogue pain score, timed up and go test, a 10 meter walk test, and length of stay. Blood loss and the incidence of blood transfusions were also recorded.
  
  
  
  There were no statistically significant differences between the primary outcome of thigh swelling or the secondary outcome measures of postoperative pain nor mobility. There was a significant reduction in length of stay for those that received TXA 3.58 days (0.84) compared with the control group 4.27 days (0.98) (P < .001). There was significantly less intraoperative blood loss observed in the TXA group (0.460L SD 0.228) compared with the control group (0.687L SD 0.283L) (P < .001). The estimated blood loss was also significantly less in the TXA group (1.084L SD 0.440) compared with the control group (1.394 L SD 0.426).
  
  
  
  TXA is an effective agent in reducing blood loss in total hip arthroplasty using the anterior approach. The blood conserving effect of TXA was not associated with improved postoperative recovery across the measures of pain and mobility. Administration of TXA may have a positive effect on reducing the duration of inpatient stays.
authors.affiliation: Western Health, Orthopaedics, Footscray, VIC, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Fraval
authors.affiliation: St Vincents Private, East Melbourne, Fitzroy, VIC, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Effeney
authors.affiliation: St Vincents Private, East Melbourne, Fitzroy, VIC, Australia.
authors.forename: Lena
authors.initials: L
authors.lastname: Fiddelaers
authors.affiliation: St Vincents Private, East Melbourne, Fitzroy, VIC, Australia.
authors.forename: Belinda
authors.initials: B
authors.lastname: Smith
authors.affiliation: St Vincents Private, East Melbourne, Fitzroy, VIC, Australia.
authors.forename: Ben
authors.initials: B
authors.lastname: Towell
authors.affiliation: Western Health, Orthopaedics, Footscray, VIC, Australia; St Vincents Private, East Melbourne, Fitzroy, VIC, Australia.
authors.forename: Phong
authors.initials: P
authors.lastname: Tran
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation / Q000379:methods*; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011184:Postoperative Period; D014148:Tranexamic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: anterior approach; blood loss; post operative outcomes; total hip arthroplasty; tranexamic acid