title: Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population.
abstract: Keloid disease (KD) is a benign fibroproliferative scarring condition of unknown etiopathogenesis. Plasminogen activator inhibitor-1 (PAI-1) and vitamin D receptor (VDR) have been shown to play important roles in the progression of tissue fibrosis; therefore, both these genes are potential susceptibility genes for KD. We aimed to determine whether the gene expression levels of PAI-1 and VDR are altered in Chinese KD patients. We measured the expression of PAI and VDR in human peripheral blood lymphocytes in 236 patients with keloid and 219 age- and sex-matched healthy controls by quantitative real-time polymerase chain reaction. We found that PAI-1 expression in peripheral blood lymphocytes was significantly higher in patients with KD than in control individuals (p < 0.0001), while VDR expression was significantly lower in KD patients than in control individuals (p < 0.0001). High levels of PAI-1 and low levels of VDR expression were significantly associated with an increased risk for KD. PAI-1 and VDR might play important roles in keloid development. Gene expression levels of PAI-1 and VDR may, therefore, be used as potential markers for the prediction of keloid development after scarring.
authors.affiliation: Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Gong
authors.affiliation: Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China.
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Ji
authors.affiliation: Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China.
authors.forename: Tie
authors.initials: T
authors.lastname: Xiang
authors.affiliation: Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China.
authors.forename: Chang-Kai
authors.initials: CK
authors.lastname: Zhou
authors.affiliation: Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China.
authors.forename: Xuan-Liang
authors.initials: XL
authors.lastname: Pan
authors.affiliation: Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu Province, China. Electronic address: pxuanliang@sina.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D007627:Keloid / Q000097:blood / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000235:genetics*; D011379:Prognosis; D018167:Receptors, Calcitriol / Q000097:blood / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D018167:Receptors, Calcitriol; C051321:SERPINE1 protein, human; C579457:VDR protein, human
keywords: Chinese population; Keloid disease; Peripheral blood lymphocytes; Plasminogen activator inhibitor; Vitamin D receptor