title: MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
abstract: BACKGROUND
  Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
  
  
  METHODS
  Retrospective analysis of 184 benign adnexal tumors (140 eccrine/apocrine, 40 follicular and 10 sebaceous), and 30 malignant adnexal tumors was performed with MYB, SOX-10 and CD117 immunostaining.
  
  
  RESULTS
  In the benign adnexal tumors, 16% (23/140) significantly expressed MYB. MYB expression was limited to cylindromas and to a lesser extent, spiradenomas in the benign cohort. Elevated MYB expression was detected in mucinous carcinoma, endocrine mucin-producing sweat gland carcinoma and 1 and 4 cases of extramammary Paget's disease (EMPD) in the malignant cohort. CD117 and SOX-10 had similar overall positivity rates in benign apocrine and eccrine tumors (45% and 68% respectively), and were generally negative in other benign and malignant adnexal tumors.
  
  
  CONCLUSIONS
  Expression of MYB appears limited to a small number of cutaneous adnexal tumors, including cylindromas, spiradenomas, ACCs, mucinous carcinoma, endocrine mucin-producing sweat gland carcinoma and some cases of EMPD.
authors.affiliation: Departments of Dermatology and Pathology, University of California, San Francisco, California.
authors.forename: Mara Therese P
authors.identifier: http://orcid.org/0000-0001-9250-916X
authors.initials: MT
authors.lastname: Evangelista
authors.affiliation: Departments of Dermatology and Pathology, University of California, San Francisco, California.
authors.forename: Jeffrey P
authors.identifier: http://orcid.org/0000-0003-3973-5314
authors.initials: JP
authors.lastname: North
mesh_terms: D000291:Adnexal Diseases / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis*; D020598:Proto-Oncogene Proteins c-myb / Q000096:biosynthesis*; D012189:Retrospective Studies; D055757:SOXE Transcription Factors / Q000096:biosynthesis*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D020598:Proto-Oncogene Proteins c-myb; C527923:SOX10 protein, human; D055757:SOXE Transcription Factors; D019009:Proto-Oncogene Proteins c-kit
keywords: CD117; MYB; SOX-10; cutaneous adnexal tumors