title: A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease.
abstract: This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease. A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples. The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture. Our results confirm the potentially important role of human demographic history when performing epidemiological studies.
authors.affiliation: Faculty of Biology, Department of Evolutionary Biology, Ecology and Environmental Sciences, Biodiversity Research Institute, University of Barcelona,Barcelona, Spain.
authors.forename: Miguel M
authors.initials: MM
authors.lastname: Álvarez-Álvarez
authors.affiliation: Faculty of Biology, Department of Evolutionary Biology, Ecology and Environmental Sciences, Biodiversity Research Institute, University of Barcelona,Barcelona, Spain.
authors.forename: Daniela
authors.initials: D
authors.lastname: Zanetti
authors.affiliation: Faculty of Biology, Department of Evolutionary Biology, Ecology and Environmental Sciences, Biodiversity Research Institute, University of Barcelona,Barcelona, Spain.
authors.forename: Robert
authors.initials: R
authors.lastname: Carreras-Torres
authors.affiliation: Faculty of Biology, Department of Evolutionary Biology, Ecology and Environmental Sciences, Biodiversity Research Institute, University of Barcelona,Barcelona, Spain.
authors.forename: Pedro
authors.identifier: 0000-0001-5072-5892
authors.initials: P
authors.lastname: Moral
authors.affiliation: Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
authors.forename: Georgios
authors.initials: G
authors.lastname: Athanasiadis
mesh_terms: D017954:Africa South of the Sahara; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D051456:Gene Flow; D056426:Genetic Loci; D006801:Humans; D015810:Linkage Disequilibrium; D019083:Mediterranean Region; D020641:Polymorphism, Single Nucleotide