title: The nervous system of airways and its remodeling in inflammatory lung diseases.
abstract: Inflammatory lung diseases are associated with bronchospasm, cough, dyspnea and airway hyperreactivity. The majority of these symptoms cannot be primarily explained by immune cell infiltration. Evidence has been provided that vagal efferent and afferent neurons play a pivotal role in this regard. Their functions can be altered by inflammatory mediators that induce long-lasting changes in vagal nerve activity and gene expression in both peripheral and central neurons, providing new targets for treatment of pulmonary inflammatory diseases.
authors.affiliation: Institute of Anatomy and Cell Biology, Aulweg 123, 35385, Giessen, Germany.|German Center for Lung Research (DZL), Giessen, Germany.
authors.forename: Katrin Julia
authors.initials: KJ
authors.lastname: Audrit
authors.affiliation: Institute of Anatomy and Cell Biology, Aulweg 123, 35385, Giessen, Germany.|German Center for Lung Research (DZL), Giessen, Germany.
authors.forename: Lucas
authors.initials: L
authors.lastname: Delventhal
authors.affiliation: Institute of Anatomy and Cell Biology, Aulweg 123, 35385, Giessen, Germany.|German Center for Lung Research (DZL), Giessen, Germany.
authors.forename: Öznur
authors.initials: Ö
authors.lastname: Aydin
authors.affiliation: Institute of Anatomy and Cell Biology, Aulweg 123, 35385, Giessen, Germany. christina.nassenstein@anatomie.med.uni-giessen.de.|German Center for Lung Research (DZL), Giessen, Germany. christina.nassenstein@anatomie.med.uni-giessen.de.
authors.forename: Christina
authors.initials: C
authors.lastname: Nassenstein
mesh_terms: D056151:Airway Remodeling; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology*; D008168:Lung / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology*; D008171:Lung Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D009473:Neuronal Plasticity; D011984:Sensory Receptor Cells / Q000473:pathology
keywords: Allergic asthma; Central sensitization; Chronic obstructive lung disease (COPD); Nucleus tractus solitarii (NTS); Peripheral sensitization; Transient receptor potential ankyrin 1 (TRPA1); Transient receptor potential vanilloid 1 (TRPV1); Vagal ganglia