title: Understanding the Property-Activity Relationships of Polyhedral Cuprous Oxide Nanocrystals in Terms of Reactive Crystallographic Facets.
abstract: The property-activity relationship is usually established to understand the toxicity mechanism of nanomaterials. In the present study, different morphological Cu2O nanocrystals, octahedrons, truncated octahedrons, cuboctahedrons, and cubes, were synthesized to precisely tuning the {100} and {111} facet percentages in purpose of systematically investigating the toxicity role of crystallographic facets in BEAS-2B and RAW 264.7 cells. It was found that the toxicity of polyhedral Cu2O nanocrystals was highly dependent on the exposed {100} surface after short-term exposure because {100} facets could produce more reactive oxygen species (ROS) than {111} facets; however, after long-term exposure, their toxicity showed again the correlation with total surface property because toxic copper ions were largely released from the whole nanocrystal surface irrespective of {100} or {111} facet and this copper dissolution caused the collapse of surface crystals and the vanishing of ROS. This study reveals the potential hazard of crystallographic facets based on ROS and metal dissolution mechanism at the different exposure time.
authors.affiliation: Laboratory of Chemical Biology, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.|University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Laboratory of Chemical Biology, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.|University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Laboratory of Chemical Biology, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Sun
authors.affiliation: Laboratory of Chemical Biology, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.affiliation: Laboratory of Chemical Biology, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: School of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, PR China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Laboratory of Chemical Biology, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Changchun 130022, PR China.|University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Haiyuan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry* / Q000633:toxicity*; D003461:Crystallography; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity*; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D003300:Copper; C000520:cuprous oxide
keywords: Cu2O nanocrystals; facets; metal dissolution.; surface reactivity; toxicity