title: MALDI-imaging enables direct observation of kinetic and thermodynamic products of mixed peptide fiber assembly.
abstract: Controlling the self-assembly of multicomponent systems provides a key to designing new materials and understanding the molecular complexity of biology. Here, we demonstrate the first use of MALDI-imaging to characterize a multicomponent self-assembling peptide fiber. Observations of mixed peptide systems over time demonstrate how simple sequence variation can change the balance between kinetic and thermodynamic products.
authors.affiliation: School of Chemical Sciences, Auckland University, Symonds St., Auckland 1010, New Zealand. k.medini@auckland.ac.nz j.gerrard@auckland.ac.nz.
authors.forename: Karima
authors.initials: K
authors.lastname: Medini
authors.forename: Brandi
authors.initials: B
authors.lastname: West
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
authors.forename: Juliet A
authors.initials: JA
authors.lastname: Gerrard
mesh_terms: D007700:Kinetics; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013816:Thermodynamics
chemical_list: D010455:Peptides