title: Minocycline-Induced Hyperpigmentation Mimicking Aortic Dissection.
abstract: Minocycline-induced hyperpigmentation of tissues has been documented previously, but extensive cardiovascular involvement is rarely described in literature. We report a case of marked cardiovascular hyperpigmentation resulting from approximately 4 years of minocycline exposure. We will highlight how intraoperative differentiation of minocycline-induced hyperpigmentation from more sinister causes of discoloration led to the appropriate surgical management.
authors.affiliation: Department of Pathology, Hartford Hospital, Hartford, Connecticut. Electronic address: tinera.buckley@gmail.com.
authors.forename: Tinera
authors.initials: T
authors.lastname: Buckley
authors.affiliation: Department of Anesthesiology, Hartford Hospital, Hartford, Connecticut; Department of Anesthesiology, University of Connecticut School of Medicine, Farmington, Connecticut.
authors.forename: Justin
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology, Hartford Hospital, Hartford, Connecticut; Department of Anesthesiology, University of Connecticut School of Medicine, Farmington, Connecticut.
authors.forename: Keith E
authors.initials: KE
authors.lastname: Gipson
authors.affiliation: Department of Pathology, Hartford Hospital, Hartford, Connecticut.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Earle
mesh_terms: D000784:Aortic Dissection / Q000175:diagnosis*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D001014:Aortic Aneurysm / Q000175:diagnosis*; D001021:Aortic Valve / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000175:diagnosis; D007431:Intraoperative Complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery; D035583:Rare Diseases; D018570:Risk Assessment
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline