title: Effect of Tramadol on Rabbit Uterine Contractile Activity Induced in Late Pregnancy.
abstract: Effect of Tramadol infusion (5 mg/ml) on oxytocin-induced uterine contractile activity was studied in chronic experiment on female rabbits with different degrees of biological readiness for parturition. In case of sufficient biological readiness for parturition, Tramadol did not change the number of uterine contractions, but increased the amplitude and duration of each contraction against the background of increased creatine phosphate consumption by the myometrium. At the same time, Tramadol infusion to females without biological readiness for partirition suppressed induced uterine contractile activity by reducing the amplitude of each uterine contraction.
authors.affiliation: D. O. Ott Research Institute of Obstetrics, Gynecology and Reproduction, St. Petersburg, Russia. barabulka875@gmail.com.
authors.forename: A A
authors.initials: AA
authors.lastname: Yakovleva
authors.affiliation: D. O. Ott Research Institute of Obstetrics, Gynecology and Reproduction, St. Petersburg, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Nazarova
authors.affiliation: D. O. Ott Research Institute of Obstetrics, Gynecology and Reproduction, St. Petersburg, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Prokopenko
authors.affiliation: D. O. Ott Research Institute of Obstetrics, Gynecology and Reproduction, St. Petersburg, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Pavlova
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport; D004576:Electromyography; D005260:Female; D007751:Labor, Induced / Q000379:methods; D009215:Myometrium / Q000187:drug effects* / Q000502:physiology; D010120:Oxytocics / Q000494:pharmacology*; D036801:Parturition / Q000187:drug effects* / Q000502:physiology; D010725:Phosphocreatine / Q000378:metabolism; D011247:Pregnancy; D011817:Rabbits; D014147:Tramadol / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology
chemical_list: D000701:Analgesics, Opioid; D010120:Oxytocics; D010725:Phosphocreatine; D014147:Tramadol
keywords: electromyography; female rabbits; induced parturition; phosphocreatine; tramadol