title: Cyclodextrins as inhibitors of the precipitation of riboflavin-5'-phosphate due to presence of zinc chloride: A NMR investigation.
abstract: Several cyclodextrins (CDs) were probed in order to counteract the precipitation of riboflavin-5'-phosphate (or flavin mononucleotide, FMN-P) due to the presence of divalent cations, by exploiting Nuclear Magnetic Resonance (NMR) spectroscopy both for quantitative analyses and stereochemical characterizations. Among CDs, β-cyclodextrin (β-CD) showed the best solubilizing power in virtue of the formation of a 1-2 FMN-P/β-CD complex, the stereochemistry of which was ascertained by ROESY (Rotating-frame Overhauser Enhanced SpectroscopY) measurements.
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, via G. Moruzzi 13, 56124 Pisa, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Aiello
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, via G. Moruzzi 13, 56124 Pisa, Italy. Electronic address: gloria.uccello.barretta@unipi.it.
authors.forename: Gloria
authors.initials: G
authors.lastname: Uccello-Barretta
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, via G. Moruzzi 13, 56124 Pisa, Italy.
authors.forename: Niccolò
authors.initials: N
authors.lastname: Falugiani
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, via G. Moruzzi 13, 56124 Pisa, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Nardelli
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Pisa, via G. Moruzzi 13, 56124 Pisa, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Balzano
mesh_terms: D002712:Chlorides; D003505:Cyclodextrins; D005486:Flavin Mononucleotide; D009682:Magnetic Resonance Spectroscopy; D010710:Phosphates; D012995:Solubility; D017967:Zinc Compounds
chemical_list: D002712:Chlorides; D003505:Cyclodextrins; D010710:Phosphates; D017967:Zinc Compounds; D005486:Flavin Mononucleotide; C016837:zinc chloride
keywords: Complexation phenomena; Cyclodextrins; Nuclear magnetic resonance; Riboflavin 5’-phosphate; Solubility