title: Mass Spectrometry Imaging in Oncology Drug Discovery.
abstract: Over the last decade mass spectrometry imaging (MSI) has been integrated in to many areas of drug discovery and development. It can have significant impact in oncology drug discovery as it allows efficacy and safety of compounds to be assessed against the backdrop of the complex tumour microenvironment. We will discuss the roles of MSI in investigating compound and metabolite biodistribution and defining pharmacokinetic -pharmacodynamic relationships, analysis that is applicable to all drug discovery projects. We will then look more specifically at how MSI can be used to understand tumour metabolism and other applications specific to oncology research. This will all be described alongside the challenges of applying MSI to industry research with increased use of metrology for MSI.
authors.affiliation: Mass Spectrometry Imaging Group, Pathology Sciences, Drug Safety & Metabolism, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom. Electronic address: Richard.Goodwin@astrazeneca.com.
authors.forename: R J A
authors.initials: RJ
authors.lastname: Goodwin
authors.affiliation: National Physical Laboratory, Teddington, United Kingdom; School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Bunch
authors.affiliation: DMPK, Oncology IMED, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom.
authors.forename: D F
authors.initials: DF
authors.lastname: McGinnity
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D055808:Drug Discovery; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents
keywords: PK/PD; drug delivery; microenvironment