title: Peripheral blood CD34+cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis.
abstract: OBJECTIVE
  To evaluate the levels of peripheral blood CD34+cells in women who subsequently had a spontaneous miscarriage (SM).
  
  
  METHODS
  We enrolled 11 women who had SM, matching them for age, BMI and gestational age with 33 healthy pregnancies (controls). From a blood sample at 9th-11th weeks of pregnancy, we evaluated PAPP-A, free β-hCG, T (suppressor and helper), NK, B, CD34+cells.
  
  
  RESULTS
  In peripheral blood of women who had SM, PAPP-A and CD34+cells were significantly lower (p < 0.001) compared to control group.
  
  
  CONCLUSIONS
  CD34+cell low level in peripheral blood is associated with increased risk of SM.
authors.affiliation: a Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi" , University of Messina , Messina , Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Giordano
authors.affiliation: b Department of Experimental Medicine , University of Messina , Messina , Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Loddo
authors.affiliation: a Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi" , University of Messina , Messina , Italy.
authors.forename: Antonio Simone
authors.identifier: http://orcid.org/0000-0003-1543-2802
authors.initials: AS
authors.lastname: Laganà
authors.affiliation: c Nephrology and Dialysis Unit , "Pugliese-Ciaccio" Hospital of Catanzaro , Catanzaro , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Coppolino
authors.affiliation: a Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi" , University of Messina , Messina , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zoccali
authors.affiliation: b Department of Experimental Medicine , University of Messina , Messina , Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Di Benedetto
authors.affiliation: a Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi" , University of Messina , Messina , Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Santamaria
authors.affiliation: b Department of Experimental Medicine , University of Messina , Messina , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
authors.affiliation: a Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi" , University of Messina , Messina , Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: D'Anna
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood*; D000328:Adult; D018952:Antigens, CD34 / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D055815:Young Adult
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A
keywords: CD34; Hematopoietic stem cells; first trimester; miscarriage; peripheral blood