title: Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound.
abstract: This systematic experimental investigation reveals that high-frequency ultrasound irradiation (550 kHz) induced oxidation of D-glucose to glucuronic acid in excellent yield without assistance of any (bio)catalyst. Oxidation is induced thanks to the in situ production of radical species in water. Experiments show that the dissolved gases play an important role in governing the nature of generated radical species and thus the selectivity for glucuronic acid. Importantly, this process yields glucuronic acid instead of glucuronate salt typically obtained via conventional (bio)catalyst routes, which is of huge interest in respect of downstream processing. Investigations using disaccharides revealed that radicals generated by high frequency ultrasound were also capable of promoting tandem hydrolysis/oxidation reactions.
authors.affiliation: INCREASE (FR CNRS 3707), ENSIP, 1 rue Marcel Doré, TSA41105, 86073 Poitiers Cedex 9, France.
authors.forename: Prince N
authors.initials: PN
authors.lastname: Amaniampong
authors.affiliation: Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers, CNRS, ENSIP, 1 rue Marcel Doré, TSA41105, 86073 Poitiers Cedex 9, France.
authors.forename: Ayman
authors.initials: A
authors.lastname: Karam
authors.affiliation: Cambridge Centre for Advanced Research and Education in Singapore (CARES), Nanyang Technological University, 1 Create Way, 138602, Singapore.
authors.forename: Quang Thang
authors.initials: QT
authors.lastname: Trinh
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.
authors.forename: Hajime
authors.initials: H
authors.lastname: Hirao
authors.affiliation: INCREASE (FR CNRS 3707), ENSIP, 1 rue Marcel Doré, TSA41105, 86073 Poitiers Cedex 9, France.|Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers, CNRS, ENSIP, 1 rue Marcel Doré, TSA41105, 86073 Poitiers Cedex 9, France.
authors.forename: François
authors.initials: F
authors.lastname: Jérôme
authors.affiliation: INCREASE (FR CNRS 3707), ENSIP, 1 rue Marcel Doré, TSA41105, 86073 Poitiers Cedex 9, France.|Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers, CNRS, ENSIP, 1 rue Marcel Doré, TSA41105, 86073 Poitiers Cedex 9, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Chatel
mesh_terms: D002241:Carbohydrates / Q000737:chemistry; D002384:Catalysis / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D005947:Glucose / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000528:radiation effects*; D012996:Solutions; D000069453:Ultrasonic Waves
chemical_list: D002241:Carbohydrates; D012996:Solutions; D020723:Glucuronic Acid; D005947:Glucose