title: Incidences, risk factors and outcomes of neonatal thromboembolism.
abstract: BACKGROUND
  The incidences of thromboembolism (TE) in neonates were reported to be around 0.51 per 10,000 live births per year for overall TE and 24 per 10,000 NICU admissions per year. As the incidences of TE in children and adults are lower in Asian populations, the incidences, risk factors, and outcomes of neonatal TE may be different to those reports from other countries.
  
  
  OBJECTIVE
  To determine the incidences, risk factors, and outcomes of neonatal TE in a tertiary care hospital in Thailand.
  
  
  METHODS
  A retrospective study between the years 1998 and 2015.
  
  
  RESULTS
  From a total of 2463 neonatal admissions, 28 patients were diagnosed with TE. The female/male ratio was 1:1.2. The breakdown of diagnoses of neonatal TE were arterial ischemic stroke (AIS; 36%), arterial TE (ATE; 29%), deep vein thrombosis (DVT; 14%), cerebral venous sinus thrombosis (CVST; 11%), renal vein thrombosis (RVT; 3%), and purpura fulminans (2%). Underlying diseases were identified 57.1% of patients. The most common thrombophilic risk factor was protein C (PC) deficiency (14.3%). The overall mortality rate was 14.3%.
  
  
  CONCLUSIONS
  The most common TE was AIS. PC deficiency was the most prevalent inherited risk factor, especially in neonates without precipitating factors.
authors.affiliation: a Depatment of Pediatrics , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Nongnuch
authors.initials: N
authors.lastname: Sirachainan
authors.affiliation: a Depatment of Pediatrics , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Anchalee
authors.initials: A
authors.lastname: Limrungsikul
authors.affiliation: a Depatment of Pediatrics , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Ampaiwan
authors.initials: A
authors.lastname: Chuansumrit
authors.affiliation: a Depatment of Pediatrics , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Pracha
authors.initials: P
authors.lastname: Nuntnarumit
authors.affiliation: a Depatment of Pediatrics , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Lunliya
authors.initials: L
authors.lastname: Thampratankul
authors.affiliation: b Department of Pediatrics , Buddhachinaraj Hospital , Phitsanulok , Thailand.
authors.forename: Somporn
authors.initials: S
authors.lastname: Wangruangsathit
authors.affiliation: a Depatment of Pediatrics , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Werasak
authors.initials: W
authors.lastname: Sasanakul
authors.affiliation: a Depatment of Pediatrics , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Praguywan
authors.initials: P
authors.lastname: Kadegasem
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers; D013785:Thailand / Q000453:epidemiology; D013923:Thromboembolism / Q000453:epidemiology*
keywords: Neonate; outcome; protein C deficiency; risk factors; thromboembolism