title: A tailored-guided internet-based cognitive-behavioral intervention for patients with rheumatoid arthritis as an adjunct to standard rheumatological care: results of a randomized controlled trial.
abstract: For patients with chronic pain conditions such as rheumatoid arthritis (RA), who experience elevated levels of distress, tailored-guided internet-based cognitive-behavioral treatment may be effective in improving psychological and physical functioning, and reducing the impact of RA on daily life. A multicenter, randomized controlled trial was conducted for RA patients with elevated levels of distress as assessed by a disease-specific measure. The control group (n = 71) received standard care and the intervention group (n = 62) additionally received an internet-based tailored cognitive-behavioral intervention. Main analyses were performed using a linear mixed model estimating differences between the intervention and control groups in scores of psychological functioning, physical functioning, and impact of RA on daily life at preassesment and postassessment, and at 3, 6, 9, and 12 months. Patients who received the internet-based intervention reported a larger improvement in psychological functioning compared with the control group, indicating less depressed mood (P < 0.001, d = 0.54), negative mood (P = 0.01, d = 0.38), and anxiety (P < 0.001, d = 0.48) during the course of the 1-year follow-up period. Regarding physical functioning, a trend was found for the intervention group reporting less fatigue than the control group (P = 0.06, d = 0.24), whereas no effect was found on pain. No effects were found for the impact of RA on daily life, except for the intervention group experiencing fewer role limitations due to emotional problems (P < 0.001, d = 0.53). Offering guided internet-based cognitive-behavioral therapy is a promising development to aid patients with psychological distress particularly in improving psychological functioning. Further research on adherence and specific intervention ingredients is warranted.
authors.affiliation: Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.|Departments of Medical Psychology and.
authors.forename: Maaike
authors.initials: M
authors.lastname: Ferwerda
authors.affiliation: Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.|Departments of Medical Psychology and.
authors.forename: Sylvia
authors.initials: S
authors.lastname: van Beugen
authors.affiliation: Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.|Departments of Medical Psychology and.
authors.forename: Henriët
authors.initials: H
authors.lastname: van Middendorp
authors.affiliation: Departments of Medical Psychology and.
authors.forename: Saskia
authors.initials: S
authors.lastname: Spillekom-van Koulil
authors.affiliation: Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: A Rogier T
authors.initials: ART
authors.lastname: Donders
authors.affiliation: Department of Rheumatology, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Henk
authors.initials: H
authors.lastname: Visser
authors.affiliation: Department of Psychology, Health and Technology, Arthritis Centre Twente, University of Twente, Enschede, the Netherlands.
authors.forename: Erik
authors.initials: E
authors.lastname: Taal
authors.affiliation: Department of Rheumatology, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, the Netherlands.
authors.forename: Marjonne C W
authors.initials: MCW
authors.lastname: Creemers
authors.affiliation: Scientific Institute for Quality of Healthcare, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Piet C L M
authors.initials: PCLM
authors.lastname: van Riel
authors.affiliation: Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.|Departments of Medical Psychology and.
authors.forename: Andrea W M
authors.initials: AWM
authors.lastname: Evers
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000523:psychology / Q000628:therapy; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology* / Q000534:rehabilitation*; D009426:Netherlands; D017063:Outcome Assessment, Health Care; D010147:Pain Measurement; D010808:Physical Examination; D011569:Psychiatric Status Rating Scales; D013997:Time Factors