title: Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer.
abstract: Biocompatibility of intraocular lens (IOL) is critical to vision reconstruction after cataract surgery. Foldable hydrophobic acrylic IOL is vulnerable to the adhesion of extracellular matrix proteins and cells, leading to increased incidence of postoperative inflammation and capsule opacification. To increase IOL biocompatibility, we synthesized a hydrophilic copolymer P(MPC-MAA) and grafted the copolymer onto the surface of IOL through air plasma treatment. X-ray photoelectron spectroscopy, atomic force microscopy and static water contact angle were used to characterize chemical changes, topography and hydrophilicity of the IOL surface, respectively. Quartz crystal microbalance with dissipation (QCM-D) showed that P(MPC-MAA) modified IOLs were resistant to protein adsorption. Moreover, P(MPC-MAA) modification inhibited adhesion and proliferation of lens epithelial cells (LECs) in vitro. To analyze uveal and capsular biocompatibility in vivo, we implanted the P(MPC-MAA) modified IOLs into rabbits after phacoemulsification. P(MPC-MAA) modification significantly reduced postoperative inflammation and anterior capsule opacification (ACO), and did not affect posterior capsule opacification (PCO). Collectively, our study suggests that surface modification by P(MPC-MAA) can significantly improve uveal and capsular biocompatibility of hydrophobic acrylic IOL, which could potentially benefit patients with blood-aqueous barrier damage.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
authors.forename: Xuhua
authors.initials: X
authors.lastname: Tan
authors.affiliation: National Engineering Research Center for Human Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, 510006, China.|School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510641, China.
authors.forename: Jiezhao
authors.initials: J
authors.lastname: Zhan
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510641, China.|EYEGOOD Medicals Co., Ltd, Zhuhai, Guangdong, 519085, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Cao
authors.affiliation: National Engineering Research Center for Human Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, 510006, China.|School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510641, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Human Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, 510006, China.|School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510641, China.
authors.forename: Sa
authors.initials: S
authors.lastname: Liu
authors.affiliation: National Engineering Research Center for Human Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, 510006, China.|School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510641, China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University 54 South Xianlie Rd, Guangzhou, China.
authors.forename: Yingyan
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Cataract, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
authors.forename: Mingxing
authors.initials: M
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: National Engineering Research Center for Human Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, 510006, China.|School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510641, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ren
mesh_terms: D000327:Adsorption; D000818:Animals; D057866:Anterior Capsule of the Lens / Q000187:drug effects / Q000502:physiology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D002386:Cataract / Q000473:pathology; D002387:Cataract Extraction / Q000009:adverse effects; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007249:Inflammation / Q000209:etiology; D007910:Lenses, Intraocular; D008422:Materials Testing; D008689:Methacrylates / Q000494:pharmacology*; D018625:Microscopy, Atomic Force; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D057852:Posterior Capsule of the Lens / Q000187:drug effects; D011183:Postoperative Complications / Q000209:etiology; D011817:Rabbits; D013499:Surface Properties; D014602:Uvea / Q000187:drug effects / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D010767:Phosphorylcholine; C008384:methacrylic acid; C070638:2-methacryloyloxyethyl phosphorylcholine