title: Relationship key factor of inflammation and the development of complications in the late period of myocardial infarction in patients with visceral obesity.
abstract: Cytokines play an significant role in regulating non-specific inflammatory response involved in many pathological processes. The current study tested the hypothesis that myocardial infarction in patients with obesity can lead to increased production of proinflammatory cytokines and unfavorable course of the pathological process.
  
  
  
  The study recruited 232 male patients with ST-elevated myocardial infarction. The mean age of the patients was 58.7 (52.2-69.9) years. All the patients were assigned to two groups according to the computed tomography findings: 1 (n = 160) patients with visceral obesity (VO), and 2 (n = 72) patients without VO. Interleukins were measured in blood serum on days 1 and 12 after MI.
  
  
  
  All patients with MI demonstrated elevated levels of proinflammatory markers and reduced anti-inflammatory markers in the in-hospital period. The results suggested that among all studied inflammatory markers IL-6 (OR 1.9; 95% CI (1.6-2.8) and CRP (OR 1.3; 95% CI (1.1-1.8) were closely related to VO. One year after MI adverse cardiovascular outcome frequently occurred in patients with VO. There were two cardiac deaths (3.1%), 6 cases (9.3%) of recurrent MI, 19 cases (29.6%) of repeated hospitalizations for unstable angina, whereas only 2 patients without VO (6.6%) were hospitalized for unstable angina. The results of the logistic regression analysis demonstrated that IL-6, IL-12, and IL-10 had the highest predictive value for occurrence of adverse cardiovascular events in patients with VO.
  
  
  
  Cytokine profile in MI patients with VO is characterized by an imbalance caused by elevated pro-inflammatory interleukins and decreased anti-inflammatory interleukins. Obesity in patients was associated with a marked increase in IL-6 and CRP levels.
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Gruzdeva
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia. evg.uchasova@yandex.ru.
authors.forename: Evgenya
authors.identifier: 0000-0003-4321-8977
authors.initials: E
authors.lastname: Uchasova
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Dyleva
authors.affiliation: Federal State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Ministry of Healthcare of the Russian Federation, Tomsk, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Akbasheva
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Vera
authors.initials: V
authors.lastname: Matveeva
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Karetnikova
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kokov
authors.affiliation: Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Barbarash
mesh_terms: D050154:Adiposity; D000368:Aged; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D018836:Inflammation Mediators / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D050152:Intra-Abdominal Fat / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D009765:Obesity / Q000150:complications* / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology; D016017:Odds Ratio; D010359:Patient Readmission; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D007378:Interleukins