title: C-F Bond Cleavage Enabled Redox-Neutral [4+1] Annulation via C-H Bond Activation.
abstract: Using α,α-difluoromethylene alkyne as a nontraditional one-carbon reaction partner, a synthetically novel method for the construction of isoindolin-1-one derivatives via Rh(III)-catalyzed [4+1] annulation reaction is reported. The 2-fold C-F bond cleavage not only enables the generation of desired product under an overall oxidant-free condition but also results in a net migration of carbon-carbon triple bond. In addition, the present reaction protocol exhibits a tolerance of a wide spectrum of functional groups due to the mild reaction conditions employed.
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , Nanjing 211816, P. R. China.
authors.forename: Cheng-Qiang
authors.initials: CQ
authors.lastname: Wang
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , Nanjing 211816, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ye
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , Nanjing 211816, P. R. China.
authors.forename: Chao
authors.identifier: 0000-0003-4494-6845
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.|Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637616.
authors.forename: Teck-Peng
authors.identifier: 0000-0002-2936-337X
authors.initials: TP
authors.lastname: Loh