title: Smoking Status and the Incidence of Pancreatic Cancer Concomitant With Intraductal Papillary Mucinous Neoplasm.
abstract: The effect of smoking status on the incidence of pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN) has not been clarified. This study investigated the association of smoking status with PDAC concomitant with IPMN.
  
  
  
  The subjects were 124 consecutive patients undergoing resection of IPMNs (intraductal papillary mucinous adenoma (IPMA): N = 77, invasive IPMN: N = 31, and PDAC with IPMN: N = 16) between April 2008 and October 2015. The associations between smoking status (never/former/current smoker) or cumulative pack-years (0-19/20-39/≥40) and the incidence of PDAC concomitant with IPMN or invasive IPMN were evaluated.
  
  
  
  Current smoking, not former smoking, was associated with the incidence of PDAC concomitant with IPMN (PDAC with IPMN vs IPMN alone; P = 0.004, PDAC with IPMN vs IPMA; P = 0.004, PDAC with IPMN vs invasive IPMN; P = 0.04, respectively), but not that of invasive IPMN (invasive IPMN vs IPMA; P = 0.85). Cumulative pack-years were higher in patients who had PDAC concomitant with IPMN than in patients with invasive IPMN (P = 0.04). Cumulative pack-years were not associated with smoking status (current vs former).
  
  
  
  Current smoking, not former smoking, was associated with the incidence of PDAC concomitant with IPMN. Cessation of smoking may be recommended for patients with IPMN.
authors.affiliation: From the *Division of Gastroenterology, Department of Internal Medicine, †Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, ‡Division of Diagnostic Pathology, §Department of Radiology, Kobe University Graduate School of Medicine, Hyogo; and ∥Center for Clinical Research and Advanced Medicine Establishment, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Masuda
authors.forename: Hirochika
authors.initials: H
authors.lastname: Toyama
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Shiomi
authors.forename: Yoh
authors.initials: Y
authors.lastname: Zen
authors.forename: Keitaro
authors.initials: K
authors.lastname: Sofue
authors.forename: Mamoru
authors.initials: M
authors.lastname: Takenaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yagi
authors.forename: Kodai
authors.initials: K
authors.lastname: Yamanaka
authors.forename: Masaru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Arisaka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okabe
authors.forename: Hiromu
authors.initials: H
authors.lastname: Kutsumi
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukumoto
authors.forename: Yonson
authors.initials: Y
authors.lastname: Ku
authors.forename: Takeshi
authors.initials: T
authors.lastname: Azuma
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology* / Q000601:surgery; D000231:Adenocarcinoma, Papillary / Q000453:epidemiology* / Q000601:surgery; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000453:epidemiology* / Q000601:surgery; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000601:surgery; D012907:Smoking