title: Divergent Synthesis of Quinolone Natural Products fromPseudonocardiasp. CL38489.
abstract: Two divergent synthetic routes are reported offering access to four quinolone natural products fromPseudonocardiasp. CL38489. Key steps to the natural products involved a regioselective epoxidation, an intramolecular Buchwald-Hartwig amination and a final acid-catalysed 1,3-allylic-alcohol rearrangement to give two of the natural products in one step. This study completes the synthesis of all eight antibacterial quinolone natural products reported in the family. In addition, this modular strategy enables an improved synthesis towards two natural products previously reported.
authors.affiliation: Department of Chemistry University of Cambridge Lensfield Road CB2 1EW Cambridge UK.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Geddis
authors.affiliation: Department of Chemistry University of Cambridge Lensfield Road CB2 1EW Cambridge UK.
authors.forename: Laura
authors.identifier: 0000-0002-2093-2222
authors.initials: L
authors.lastname: Carro
authors.affiliation: Department of Chemistry University of Cambridge Lensfield Road CB2 1EW Cambridge UK.
authors.forename: James T
authors.initials: JT
authors.lastname: Hodgkinson
authors.affiliation: Department of Chemistry University of Cambridge Lensfield Road CB2 1EW Cambridge UK.
authors.forename: David R
authors.identifier: 0000-0001-7355-2824
authors.initials: DR
authors.lastname: Spring
keywords: Antibacterial agents; Cross‐coupling; Michael addition; Natural products; Quinolones