title: Relationship between IL-27 and coronary arterial lesions in children with Kawasaki disease.
abstract: Kawasaki disease (KD) arises due to the disorder of the inflammation response and faulty immune regulation. Interleukin-27 (IL-27) is a novel cytokine with both pro-inflammatory and anti-inflammatory effects. This study investigated the relationship between serum levels of IL-27, Interleukin-17A (IL-17A), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 81 children with KD before intravenous immunoglobulin (IVIG) therapy. Levels of IL-27, IL-17A, IL-10, IL-6, IL-1β and TNF-α were measured in 251 cases, including 4 groups: the normal control group, NC (n = 90), febrile control, FC (n = 80), KD without coronary arteries (n = 41) and KD with coronary arterial lesions (n = 40). White blood cells counts (WBC), red blood cells counts (RBC), hemoglobin, C-reactive protein (CRP), erythrocyte sedimentation rate and procalcitonin (PCT) were tested in all subjects. Levels of IL-27, IL-10, IL-17A, IL-6, IL-1β and TNF-α were significantly elevated, and RBC and hemoglobin significantly decreased in the group of KD group compared with febrile and control groups. IL-27, IL-6, IL-1β and TNF-α serum levels are even higher in KD children with CALs. There was positive relationship between serum levels of IL-27 and WBC, CRP, PCT, IL-10, IL-17A, IL-6 and TNF-α in children with KD. The up-regulation of IL-27 may be closely linked to up-regulation of systemic pro-inflammatory markers in acute KD. Morover, IL-27 may be involved in the development of CALs in acute KD.
authors.affiliation: Key Laboratory of Pediatrics in Chongqing, Chongqing, 400014, People's Republic of China.|Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, 400014, People's Republic of China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Si
authors.affiliation: Key Laboratory of Pediatrics in Chongqing, Chongqing, 400014, People's Republic of China.|Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, 400014, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Laboratory of Pediatrics in Chongqing, Chongqing, 400014, People's Republic of China.|Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, 400014, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Gao
authors.affiliation: Key Laboratory of Pediatrics in Chongqing, Chongqing, 400014, People's Republic of China.|Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, 400014, People's Republic of China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, People's Republic of China. boyboip@126.com.
authors.forename: Ruixi
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, People's Republic of China. qjyi2003@hotmail.com.
authors.forename: Qijian
authors.initials: Q
authors.lastname: Yi
mesh_terms: D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007378:Interleukins / Q000097:blood*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human
keywords: Coronary arterial lesion; Interleukin-10 (IL-10); Interleukin-17A (IL-17A); Interleukin-27 (IL-27); Kawasaki disease (KD)