title: Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis.
abstract: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare hyperinflammatory disorder caused by an aberrant immune response to a number of infectious or inflammatory conditions. Successful treatment of this potentially fatal condition requires early recognition and prompt therapy directed at the underlying trigger. In this report, we describe the clinical presentation, diagnostic findings, management, and outcome of a child with Lemierre's syndrome-associated sHLH. This is the first reported association of these 2 rare conditions and expands the number of known triggers for sHLH.
authors.affiliation: *Department of Pediatrics †Division of Pediatric Hematology-Oncology ‡Department of Pathology §Division of Pediatric Infectious Diseases, University of Virginia, Charlottesville, VA.
authors.forename: Abigail V W
authors.initials: AVW
authors.lastname: Kumral
authors.forename: William C
authors.initials: WC
authors.lastname: Petersen
authors.forename: Christopher
authors.initials: C
authors.lastname: Heitz
authors.forename: Linda A
authors.initials: LA
authors.lastname: Waggoner-Fountain
authors.forename: Brian C
authors.initials: BC
authors.lastname: Belyea
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D019468:Disease Management; D005260:Female; D006801:Humans; D057831:Lemierre Syndrome / Q000150:complications*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome