title: Sleep Problems in Children With Agenesis of the Corpus Callosum.
abstract: Very little is known about sleep habits in children with agenesis of the corpus callosum (ACC). The purpose of this investigation was to evaluate sleep problems in children with ACC and examine the association with quality of life.
  
  
  
  We performed a cross-sectional, anonymous, internet-based survey offered to parents of children with ACC, aged five to 18 years. The Children's Sleep Habits Questionnaire (CSHQ) and pediatric quality of life (PedsQL) were used to assess sleep habits and quality of life, respectively. Associations between the total and all subdomains of CSHQ and PedsQL were tested.
  
  
  
  The final sample included 66 parents of children with ACC. Overall, 78% of the children had clinically significant sleep problems, using a cutoff score of 41 on the CSHQ. Compared with a prior national sample of typically developing children, children with ACC scored significantly higher overall and in all subdomains of the CSHQ. The overall CSHQ and PedsQL were moderately correlated (r = -0.485, P < 0.001), indicating that children with more sleep problems had worse quality of life. In addition, the total CSHQ correlated with all subdomains of the pediatric quality of life, including emotional (r = -0.515, P < 0.01), social (r = -0.394, P < 0.01), physical (r = -0.263, P < 0.01), and school (r = -0.362, P < 0.01). These associations remained statistically significant in multivariable regression models controlling for age and gender.
  
  
  
  Sleep problems are common and associated with lower quality of life in children with ACC.
authors.affiliation: Division of Pulmonary and Sleep Medicine, Children's Mercy Hospital, Kansas City, Missouri. Electronic address: dgingram@cmh.edu.
authors.forename: David G
authors.initials: DG
authors.lastname: Ingram
authors.affiliation: Department of Family and Child Nursing, University of Washington, Seattle, Washington.
authors.forename: Shervin S
authors.initials: SS
authors.lastname: Churchill
mesh_terms: D000293:Adolescent; D061085:Agenesis of Corpus Callosum / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020407:Internet; D008297:Male; D015999:Multivariate Analysis; D015995:Prevalence; D011788:Quality of Life; D012044:Regression Analysis; D012893:Sleep Wake Disorders / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D011795:Surveys and Questionnaires
keywords: agenesis of the corpus callosum; quality of life; sleep habits