title: Heat Shock Proteins in Multiple Sclerosis.
abstract: Multiple sclerosis (MS) is an immune-mediated and neurodegenerative central nervous system disease, mostly affect myelin sheaths. The MS pathogenesis is still under debate. It is influenced by genetic, environment factors. Heat shock proteins (HSPs) are highly conserved proteins seen in all organisms. Not only heat stress but also under many stress conditions they are overexpressed. Their roles in MS pathogenesis are highly correlated with their location (intracellular or extracellular). In this chapter, we will discuss the role of HSP in MS pathogenesis.
authors.affiliation: Division of Neurology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey. kurceren@hotmail.com.
authors.forename: Ortan
authors.initials: O
authors.lastname: Pinar
authors.affiliation: Division of İnternal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
authors.forename: Yildirim Akan
authors.initials: YA
authors.lastname: Ozden
authors.affiliation: Division of Biochemistry, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
authors.forename: Erkizan
authors.initials: E
authors.lastname: Omur
authors.affiliation: Division of Neurology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
authors.forename: Gedizlioglu
authors.initials: G
authors.lastname: Muhtesem
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D009186:Myelin Sheath / Q000378:metabolism* / Q000473:pathology
chemical_list: D006360:Heat-Shock Proteins
keywords: Heat shock proteins; Multiple sclerosis; Pathogenesis