title: Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake.
abstract: A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.
authors.affiliation: Univ. Grenoble Alpes , Département de Pharmacochimie Moléculaire, CNRS UMR 5063, ICMG FR 2607, 470 rue de la chimie, Grenoble 38041 Cedex 9, France.|Universidade Federal de Ouro Preto , Departamento de Química, ICEB, Campus Universitário Morro do Cruzeiro, 35400-000 Ouro Preto, Minas Gerais Brazil.|Universidade Federal de Minas Gerais , Depertamento de Química, UFMG, Av Pres Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Flaviane
authors.initials: F
authors.lastname: Francisco Hilário
authors.affiliation: Univ. Grenoble Alpes , Département de Pharmacochimie Moléculaire, CNRS UMR 5063, ICMG FR 2607, 470 rue de la chimie, Grenoble 38041 Cedex 9, France.|Univ. Grenoble Alpes , Département de Chimie Moléculaire, CNRS UMR 5250, ICMG FR 2607, 301 rue de la chimie, Grenoble 38041 Cedex 9, France.
authors.forename: Mohamed Dit Mady
authors.initials: MD
authors.lastname: Traoré
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , rue Michel Servet 1, 1211 Geneva, Switzerland.
authors.forename: Vincent
authors.initials: V
authors.lastname: Zwick
authors.affiliation: Laboratoire Dynamique des Interactions Membranaires Normales et Pathologiques, UMR5235, CNRS, University of Montpellier , Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Berry
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , rue Michel Servet 1, 1211 Geneva, Switzerland.
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Simões-Pires
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , rue Michel Servet 1, 1211 Geneva, Switzerland.
authors.forename: Muriel
authors.initials: M
authors.lastname: Cuendet
authors.affiliation: Univ. Grenoble Alpes , Département de Pharmacochimie Moléculaire, CNRS UMR 5063, ICMG FR 2607, 470 rue de la chimie, Grenoble 38041 Cedex 9, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fantozzi
authors.affiliation: Universidade Federal de Minas Gerais , Depertamento de Química, UFMG, Av Pres Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Rossimiriam
authors.initials: R
authors.lastname: Pereira de Freitas
authors.affiliation: Laboratoire Dynamique des Interactions Membranaires Normales et Pathologiques, UMR5235, CNRS, University of Montpellier , Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: Marjorie
authors.initials: M
authors.lastname: Maynadier
authors.affiliation: Laboratoire Dynamique des Interactions Membranaires Normales et Pathologiques, UMR5235, CNRS, University of Montpellier , Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: Sharon
authors.initials: S
authors.lastname: Wein
authors.affiliation: Laboratoire Dynamique des Interactions Membranaires Normales et Pathologiques, UMR5235, CNRS, University of Montpellier , Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Vial
authors.affiliation: Univ. Grenoble Alpes , Département de Pharmacochimie Moléculaire, CNRS UMR 5063, ICMG FR 2607, 470 rue de la chimie, Grenoble 38041 Cedex 9, France.
authors.forename: Yung-Sing
authors.identifier: 0000-0003-1038-9681
authors.initials: YS
authors.lastname: Wong
mesh_terms: D002462:Cell Membrane; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D010456:Peptides, Cyclic