title: Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva.
abstract: Squamous cell carcinoma of the vulva is predominantly a disease of the elderly, where the mainstay of treatment is radical surgery. Local vulval recurrence (LVR) is a significant problem for these patients, and the rates of recurrence have not improved over the last three decades. Disappointingly, we still lack an understanding of how LVRs develop, and the best approach to prevent and manage the condition. This review discusses recent insights into the key prognostic factors that influence the risk of recurrence, focusing on the role of tumour-adjacent non-neoplastic epithelial disorders, which are thought to play a causative role.
  
  
  CONCLUSIONS
  A review that discusses the key prognostic factors that influence local recurrence in vulval cancer.
authors.affiliation: Institute of Cancer and Genomic Sciences, College of Dental and Medical School, University of Birmingham, Edgbaston, UK.|Department of Obstetrics and Gynaecology, Birmingham City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
authors.forename: Jkw
authors.initials: J
authors.lastname: Yap
authors.affiliation: Department of Obstetrics and Gynaecology, Birmingham City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
authors.forename: D
authors.initials: D
authors.lastname: O'Neill
authors.affiliation: Department of Obstetrics and Gynaecology, Birmingham City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
authors.forename: S
authors.initials: S
authors.lastname: Nagenthiran
authors.affiliation: Institute of Cancer and Genomic Sciences, College of Dental and Medical School, University of Birmingham, Edgbaston, UK.
authors.forename: C W
authors.initials: CW
authors.lastname: Dawson
authors.affiliation: Institute of Cancer and Genomic Sciences, College of Dental and Medical School, University of Birmingham, Edgbaston, UK.|Department of Obstetrics and Gynaecology, Birmingham City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Luesley
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology; D011379:Prognosis; D012307:Risk Factors; D007724:Vulvar Lichen Sclerosus / Q000150:complications; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000821:virology
keywords: Lichen sclerosus; local disease recurrence; squamous cell carcinoma; vulva; vulvar intraepithelial neoplasia