title: Protein aggregation, misfolding and consequential human neurodegenerative diseases.
abstract: Proteins are major components of the biological functions in a cell. Biology demands that a protein must fold into its stable three-dimensional structure to become functional. In an unfavorable cellular environment, protein may get misfolded resulting in its aggregation. These conformational disorders are directly related to the tissue damage resulting in cellular dysfunction giving rise to different diseases. This way, several neurodegenerative diseases such as Alzheimer, Parkinson Huntington diseases and amyotrophic lateral sclerosis are caused. Misfolding of the protein is prevented by innate molecular chaperones of different classes. It is envisaged that work on this line is likely to translate the knowledge into the development of possible strategies for early diagnosis and efficient management of such related human diseases. The present review deals with the human neurodegenerative diseases caused due to the protein misfolding highlighting pathomechanisms and therapeutic intervention.
authors.affiliation: a Centre for Interdisciplinary Research in Basic Sciences , Jamia Millia Islamia , New Delhi , India.
authors.forename: Neha
authors.initials: N
authors.lastname: Sami
authors.affiliation: b Department of Medical Biotechnology , Yeungnam University , Gyeongsan , South Korea.
authors.forename: Safikur
authors.initials: S
authors.lastname: Rahman
authors.affiliation: a Centre for Interdisciplinary Research in Basic Sciences , Jamia Millia Islamia , New Delhi , India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Kumar
authors.affiliation: a Centre for Interdisciplinary Research in Basic Sciences , Jamia Millia Islamia , New Delhi , India.
authors.forename: Sobia
authors.initials: S
authors.lastname: Zaidi
authors.affiliation: a Centre for Interdisciplinary Research in Basic Sciences , Jamia Millia Islamia , New Delhi , India.
authors.forename: Asimul
authors.initials: A
authors.lastname: Islam
authors.affiliation: a Centre for Interdisciplinary Research in Basic Sciences , Jamia Millia Islamia , New Delhi , India.
authors.forename: Sher
authors.initials: S
authors.lastname: Ali
authors.affiliation: a Centre for Interdisciplinary Research in Basic Sciences , Jamia Millia Islamia , New Delhi , India.
authors.forename: Faizan
authors.initials: F
authors.lastname: Ahmad
authors.affiliation: a Centre for Interdisciplinary Research in Basic Sciences , Jamia Millia Islamia , New Delhi , India.
authors.forename: Md Imtaiyaz
authors.identifier: http://orcid.org/0000-0002-3663-4940
authors.initials: MI
authors.lastname: Hassan
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D018832:Molecular Chaperones; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy*; D066263:Protein Aggregation, Pathological / Q000150:complications*; D057165:Proteostasis Deficiencies / Q000150:complications*; D033581:Stem Cell Transplantation / Q000379:methods*
chemical_list: D018832:Molecular Chaperones
keywords: Protein misfolding; aggregation; amyloids; amyotrophic lateral sclerosis; pathomechanisms; stem cell