title: Coincidence of Inflamed Conjunctival Carcinoma in situ and Primary Pterygium.
abstract: BACKGROUND
  We report a rare case of carcinoma in situ (CIS) in conjunction with a primary pterygium that exhibited characteristic angiographic and histopathological findings.
  
  
  METHODS
  A 78-year-old man presented with a pterygium and a whitish tumor adjacent to the pterygium in his right eye. Indocyanine green angiography displayed that feeder vessels within the primary pterygium spread to the whitish tumor. The tumor and pterygial tissues were surgically removed. Histologically, the resected tissue contained CIS as well as squamous metaplasia. There was a marked inflammatory cell infiltration within the tumor and beneath the epithelium. Topical interferon alfa-2b was given 4 times per day for 2 months. The patient has been well without local recurrence of tumor or distal metastases to 54 follow-up months after surgery.
  
  
  CONCLUSIONS
  Because CIS can occur adjacent to pterygial tissues, long-term follow-up is necessary in patients with pterygia.
authors.affiliation: Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Endo
authors.affiliation: Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan; Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kase
authors.affiliation: Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kase
keywords: Carcinoma in situ; Histopathology; Interferon alfa-2b; Pterygium