title: Intrahepatic cholangiocarcinoma.
abstract: Cholangiocarcinoma, also referred to as cholangiocellular carcinoma (particularly in Japan), develops along the biliary tract. The tumor may be intra- or extrahepatic and have different features with specific treatments based on the site of origin. Guidelines for diagnosis and management of cholangiorcarcinoma, such as those proposed by EASL (European Association for the Study of the Liver)1and the Mayo Clinic2classify the tumor into intrahepatic, perihilar, and distal cholangiocarcinoma. There are three main macroscopic patterns of growth of cholangiocarcinoma: mass-forming, periductal-infiltrating and intraductal. A combination of mass-forming and periductal infiltrating tumors have been shown to have a poor prognosis.3Intrahepatic cholangiocarcinoma (ICC) comprises two microscopic subtypes: bile duct and cholangiolar.4The bile duct subtype has tall columnar cells that form large glands, whereas cholangiolar tumors are composed of cuboidal and low columnar cells. Patients with cholangiolar tumors, referred to as cholangiolocellular carcinoma, reportedly have a better 5-year survival rate than those with the bile duct type.4.
authors.affiliation: Division of Diagnostic Pathology, Shonan Fujisawa Tokushuukai Hospita, Japan. Electronic address: m-nakano@ctmc.jp.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakano
authors.affiliation: Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Japan.
authors.forename: Shun-Ichi
authors.initials: SI
authors.lastname: Ariizumi
authors.affiliation: Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male
chemical_list: D014408:Biomarkers, Tumor
keywords: Cholangiolocellular carcinoma; Infiltrating cholangiocarcinoma; Mass forming cholangiocarcinoma; Periductal cholangiocarcinoma; Victoria blue stain