title: Small animal models to understand pathogenesis of osteoarthritis and use of stem cell in cartilage regeneration.
abstract: Osteoarthritis (OA) is one of the most common diseases, which affect the correct functionality of synovial joints and is characterized by articular cartilage degradation. Limitation in the treatment of OA is mostly due to the very limited regenerative characteristic of articular cartilage once is damaged. Small animal models are of particular importance for mechanistic analysis to understand the processes that affect cartilage degradation. Combination of joint injury techniques with the use of stem cells has been shown to be an important tool for understanding the processes of cartilage degradation and regeneration. Implementation of stem cells and small animal models are important tools to help researchers to find a solution that could ameliorate and prevent the symptoms of OA.
authors.affiliation: Division of Trauma and Orthopaedic Surgery, Addenbrooke's Hospital, Cambridge, Cambridgeshire, UK.
authors.forename: Virginia
authors.initials: V
authors.lastname: Piombo
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology*; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D004195:Disease Models, Animal; D010003:Osteoarthritis / Q000473:pathology* / Q000628:therapy; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology
keywords: Cartilage regeneration; chondrocytes; joint surface defect; ligament transection; osteoarthritis; small animal models; stem cells; synovial joint