title: Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series.
abstract: Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However, there is a paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM). This retrospective case series of five patients (mean age of 45 years) is the first study evaluating the use of sitagliptin in patients with β-TM and DM. Four patients responded well to sitagliptin, as evidenced by a decrease in fructosamine by 77 and 96μmol/L (equivalent reduction in HbA1c of 1.5% and 1.9%) observed in two patients and reduction in the frequency of hypoglycaemia without worsening glycaemic control in two others. One patient did not respond to sitagliptin. No patients reported significant side effects. This study provides evidence that sitagliptin may be considered, with caution, for use in patients with β-TM and DM, under the close monitoring of a Diabetologist.
authors.affiliation: Department of Diabetes, Whittington Hospital, Magdala Avenue, London, N19 5NF.
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Zonoozi
authors.affiliation: Department of Diabetes, Whittington Hospital, Magdala Avenue, London, N19 5NF.
authors.forename: Maria
authors.initials: M
authors.lastname: Barnard
authors.affiliation: Department of Haematology, Whittington Hospital, Magdala Avenue, London, N19 5NF.
authors.forename: Emma
authors.initials: E
authors.lastname: Prescott
authors.affiliation: Department of Diabetes, Whittington Hospital, Magdala Avenue, London, N19 5NF.
authors.forename: Romilla
authors.initials: R
authors.lastname: Jones
authors.affiliation: Department of Haematology, Whittington Hospital, Magdala Avenue, London, N19 5NF.
authors.forename: Farrukh T
authors.initials: FT
authors.lastname: Shah
authors.affiliation: Department of Diabetes, Whittington Hospital, Magdala Avenue, London, N19 5NF.
authors.forename: Ploutarchos
authors.initials: P
authors.lastname: Tzoulis
keywords: beta thalassaemia; diabetes; sitagliptin