title: Preventive effect of Eucommia leaf extract on aortic media hypertrophy in Wistar-Kyoto rats fed a high-fat diet.
abstract: Eucommia ulmoides Oliver leaf extract (ELE) has been shown to have anti-hypertensive and anti-obesity effects in rats that are fed a high-fat diet (HFD). To explore the effects of chronic administration of ELE on body weight, blood pressure and aortic media thickness, 7-week-old male Wistar-Kyoto (WKY) rats were orally administered a normal diet, a 30% HFD, or a 5% ELE plus HFD ad libitum for 10 weeks. The HFD treatment caused mild obesity and hypertension in the normotensive rats, while rats receiving both ELE and the HFD had significantly lower body weights, less visceral and perirenal fat, lower blood pressure and thinner aortic media than the control rats receiving the HFD only. The plasma adiponectin/leptin ratio also improved in ELE-treated rats. Although plasma leptin levels were elevated in all HFD rats, adiponectin levels increased only in the ELE-treated rats. Anti-hypertensive and anti-obesity effects may be caused by the geniposidic acid (GEA) and/or asperuloside present in ELE. These findings suggest that chronic ELE administration prevents aortic media hypertrophy in early-stage obesity with hypertension. Long-term administration of ELE might inhibit the development of arteriosclerosis.
authors.affiliation: R&D Center, Kobayashi Pharmaceutical Co., Ltd, Osaka, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Hosoo
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Nagano, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koyama
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Nagano, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Nagano, Japan.
authors.forename: Ryuya
authors.initials: R
authors.lastname: Ishida
authors.affiliation: R&D Center, Kobayashi Pharmaceutical Co., Ltd, Osaka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hirata
authors.affiliation: R&D Center, Kobayashi Pharmaceutical Co., Ltd, Osaka, Japan.
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Yamaguchi
authors.affiliation: R&D Center, Kobayashi Pharmaceutical Co., Ltd, Osaka, Japan.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yamasaki
authors.affiliation: Department of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Wada
authors.affiliation: Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Higashi
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Nagano, Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D054392:Adipokines / Q000097:blood; D052436:Adipose Tissue, White / Q000187:drug effects; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology; D001018:Aortic Diseases / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D031283:Eucommiaceae; D006984:Hypertrophy / Q000517:prevention & control; D008297:Male; D008518:Medicine, East Asian Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011921:Rats, Inbred WKY; D017539:Tunica Intima / Q000187:drug effects*
chemical_list: D054392:Adipokines; D010936:Plant Extracts