title: Transcriptional dynamics of tail regeneration in Xenopus tropicalis.
abstract: In contrast to humans, many amphibians are able to rapidly and completely regenerate complex tissues, including entire appendages. Following tail amputation, Xenopus tropicalis tadpoles quickly regenerate muscle, spinal cord, cartilage, vasculature and skin, all properly patterned in three dimensions. To better understand the molecular basis of this regenerative competence, we performed a transcriptional analysis of the first 72 h of tail regeneration using RNA-Seq. Our analysis refines the windows during which many key biological signaling processes act in regeneration, including embryonic patterning signals, immune responses, bioelectrical signaling and apoptosis. Our work provides a deep database for researchers interested in appendage regeneration, and points to new avenues for further study.
authors.affiliation: Department of Genetics, Stanford University, Stanford, California, 94305.
authors.forename: Jessica
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Genetics, Stanford University, Stanford, California, 94305.|Department of Obstetrics and Gynecology, Stanford University, Stanford, California, 94305.
authors.forename: Julie
authors.initials: J
authors.lastname: Baker
authors.affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, 98195.
authors.forename: Andrea
authors.identifier: 0000-0003-3647-8105
authors.initials: A
authors.lastname: Wills
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D007814:Larva / Q000235:genetics* / Q000254:growth & development; D012038:Regeneration / Q000235:genetics*; D017423:Sequence Analysis, RNA; D015398:Signal Transduction / Q000235:genetics; D013623:Tail / Q000254:growth & development; D014158:Transcription, Genetic; D014981:Xenopus / Q000235:genetics* / Q000254:growth & development
keywords: Amphibian; genomics; organism; process; transcription