title: Prevalence and 3-year persistence of human papillomavirus serotypes in asymptomatic patients in Northern Mexico.
abstract: OBJECTIVE
  To investigate clinical outcomes and 3-year persistence of human papillomavirus (HPV) infections among women in Mexico.
  
  
  METHODS
  A prospective study enrolled sexually active women attending primary healthcare clinics in metropolitan Monterrey, Mexico, between June 3 and August 30, 2002. Baseline data were collected and participants underwent HPV screening. Patients with HPV infections were asked to attend a repeat screening appointment after 3 years, when the same screening data were gathered. Descriptive analyses were performed and the prevalence of cervical lesions and viral infections were examined.
  
  
  RESULTS
  In total, 1188 patients who underwent initial HPV screening were included. Cervical lesions were detected in 5 (0.4%) patients and 239 (20.1%) patients had HPV infections; 129 (54.0%) of these patients attended 3-year follow-up. Among the 357 HPV serotypes identified, the most prevalent serotypes were HPV-59, HPV-52, HPV-16, and HPV-56, detected 62 (17.4%), 38 (10.6%), 27 (7.6%), and 18 (5.0%) times, respectively. Of the 129 patients attending 3-year follow-up, 104 (80.6%) were clear from HPV infections, 13 (10.1%) patients had persistent HPV infections, and 12 (9.3%) had HPV infections with different HPV types.
  
  
  CONCLUSIONS
  The HPV prevalence was 20.1% in the present study; the most prevalent infections were HPV-59, HPV-52, HPV-16, and HPV-56. At 3-year follow-up, 25 (19.4%) patients had HPV infections.
authors.affiliation: Tecnologico de Monterrey, Escuela Nacional de Medicina y Ciencias de la Salud, Monterrey, Mexico.|Facultad de Medicina, Departamento de Bioquimica y Medicina Molecular, Universidad Autónoma de Nuevo Leon, San Nicolás de los Garza, Mexico.|Departamento de Ciencias Basicas, Universidad de Monterrey, San Pedro Garza García, Mexico.
authors.forename: Oscar R
authors.initials: OR
authors.lastname: Fajardo-Ramírez
authors.affiliation: Servicio de Anatomía Patológica y Citopatología, Hospital Universitario "José Eleuterio González", Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico.
authors.forename: María C
authors.initials: MC
authors.lastname: Barboza-Cerda
authors.affiliation: Tecnologico de Monterrey, Escuela Nacional de Medicina y Ciencias de la Salud, Monterrey, Mexico.|Centro de Investigación y Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo Leon, San Nicolás de los Garza, Mexico.
authors.forename: Rocío
authors.initials: R
authors.lastname: Ortiz-López
authors.affiliation: Tecnologico de Monterrey, Escuela Nacional de Medicina y Ciencias de la Salud, Monterrey, Mexico.|Centro de Investigación y Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo Leon, San Nicolás de los Garza, Mexico.
authors.forename: Augusto
authors.initials: A
authors.lastname: Rojas-Martínez
authors.affiliation: Facultad de Medicina, Departamento de Bioquimica y Medicina Molecular, Universidad Autónoma de Nuevo Leon, San Nicolás de los Garza, Mexico.
authors.forename: María L
authors.initials: ML
authors.lastname: Garza-Rodríguez
authors.affiliation: Centro Universitario contra el Cáncer, Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico.
authors.forename: Abel
authors.initials: A
authors.lastname: Sepúlveda-Flores
authors.affiliation: Centro Universitario contra el Cáncer, Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico.
authors.forename: Juan F
authors.initials: JF
authors.lastname: González-Guerrero
authors.affiliation: Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
authors.forename: Sofía
authors.initials: S
authors.lastname: Bernal-Silva
authors.affiliation: Facultad de Enfermeria, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico.
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Cerda-Flores
authors.affiliation: Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, CA, USA.
authors.forename: Itzel E
authors.initials: IE
authors.lastname: Calleja-Macías
authors.affiliation: Secretaría de Salud de Nuevo León, Monterrey, Mexico.
authors.forename: Socorro
authors.initials: S
authors.lastname: Rodríguez-Flores
authors.affiliation: Secretaría de Salud de Nuevo León, Monterrey, Mexico.
authors.forename: Esthela
authors.initials: E
authors.lastname: Sandoval-Guzmán
authors.affiliation: Secretaría de Salud de Nuevo León, Monterrey, Mexico.
authors.forename: Teresa
authors.initials: T
authors.lastname: Plascencia-Solis
authors.affiliation: Secretaría de Salud de Nuevo León, Monterrey, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Pérez-Reyes
authors.affiliation: Secretaría de Salud de Nuevo León, Monterrey, Mexico.
authors.forename: Jesús Z
authors.initials: JZ
authors.lastname: Villarreal
authors.affiliation: Facultad de Medicina, Departamento de Bioquimica y Medicina Molecular, Universidad Autónoma de Nuevo Leon, San Nicolás de los Garza, Mexico.
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Barrera-Saldaña
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008403:Mass Screening; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D011446:Prospective Studies; D065288:Serogroup; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology; D014626:Vaginal Smears; D055815:Young Adult
keywords: Cervical cancer; Cytological lesions; HPV; Persistent infection; Risk factors