title: Aminoaciduria Caused by Fanconi Syndrome in a Heifer.
abstract: A case study of renal tubular dysfunction consistent with idiopathic Fanconi syndrome is reported in an 18-month-old Holstein heifer. The clinical, biochemical, and histopathological features are described. The heifer had clinical signs of growth retardation, wasting, and persistent diarrhea. Biochemical blood analysis identified hypokalemia, hyponatremia, and hypochloremia. Urinalysis identified glycosuria, proteinuria, and acidic pH. Histological examination of the kidney disclosed mild tubular necrosis with proteinaceous casts in the lumina of renal tubules. We performed LC-HRMS on urine to confirm Fanconi syndrome. Using this technique, we identified severe generalized aminoaciduria suggestive of idiopathic renal Fanconi syndrome in this heifer.
authors.affiliation: Clinic for Ruminants, Oniris - Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire-Atlantique, France.|Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), INRA, Oniris - Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire-Atlantique, France.
authors.forename: N
authors.initials: N
authors.lastname: Cesbron
authors.affiliation: Clinic for Ruminants, Oniris - Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire-Atlantique, France.
authors.forename: L
authors.initials: L
authors.lastname: Dorso
authors.affiliation: Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), INRA, Oniris - Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire-Atlantique, France.
authors.forename: A-L
authors.initials: AL
authors.lastname: Royer
authors.affiliation: Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), INRA, Oniris - Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire-Atlantique, France.
authors.forename: G
authors.initials: G
authors.lastname: Dervilly-Pinel
authors.affiliation: Laboratoire d'Immuno-Endocrinologie Cellulaire et Moléculaire, INRA, Oniris - Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire-Atlantique, France.
authors.forename: J
authors.initials: J
authors.lastname: Hervé
mesh_terms: D000596:Amino Acids / Q000652:urine*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology / Q000473:pathology*; D005198:Fanconi Syndrome / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007673:Kidney Cortex Necrosis / Q000209:etiology / Q000662:veterinary; D000608:Renal Aminoacidurias / Q000209:etiology / Q000652:urine / Q000662:veterinary*
chemical_list: D000596:Amino Acids
keywords: Cattle; high-resolution mass spectrometry; liquid chromatography; renal tubular dysfunction