title: Design and synthesis of 28-hydroxy protopanaxadiol as a novel probe template.
abstract: To explore the antitumour mechanism of 20(S)-protopanaxadiol (PPD) while maintaining its uncovered pharmacological active site 3-hydroxyl, 28-hydroxy protopanaxadiol (17), a small molecular probe template of PPD was first designed and synthesised based on the Baldwin's reaction. Thus, 28-hydroxyl of 17 was built successfully as a derivatized site of molecular probe's functional and report groups. The important intermediates and final product were confirmed by ESI-MS and nuclear magnetic resonance spectra with good yield. These studies provided a valuable basis for probe research of PPD.
authors.affiliation: a School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong , Yantai University , Yantai , China.
authors.forename: Ze-Yun
authors.initials: ZY
authors.lastname: Liu
authors.affiliation: b State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry , China Pharmaceutical University , Nanjing , China.
authors.forename: Heng-Yuan
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: a School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong , Yantai University , Yantai , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Bi
authors.affiliation: a School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong , Yantai University , Yantai , China.
authors.forename: Xian-Xuan
authors.initials: XX
authors.lastname: Liu
authors.affiliation: a School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong , Yantai University , Yantai , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: a School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong , Yantai University , Yantai , China.
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Zhang
authors.affiliation: b State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry , China Pharmaceutical University , Nanjing , China.
authors.forename: Jin-Yi
authors.initials: JY
authors.lastname: Xu
authors.affiliation: c Tang Center for Herbal Medicine Research , University of Chicago , Chicago , IL , USA.|d Department of Anesthesia and Critical Care , University of Chicago , Chicago , IL , USA.
authors.forename: Chong-Zhi
authors.initials: CZ
authors.lastname: Wang
authors.affiliation: c Tang Center for Herbal Medicine Research , University of Chicago , Chicago , IL , USA.|d Department of Anesthesia and Critical Care , University of Chicago , Chicago , IL , USA.
authors.forename: Chun-Su
authors.initials: CS
authors.lastname: Yuan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D020134:Catalytic Domain; D015335:Molecular Probes / Q000138:chemical synthesis*; D012502:Sapogenins / Q000138:chemical synthesis*; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D015335:Molecular Probes; D012502:Sapogenins; C062916:protopanaxadiol
keywords: 28-Hydroxy protopanaxadiol; Baldwin’s reaction; probe template; synthesis