title: Geometric protein localization cues in bacterial cells.
abstract: Bacterial cells are highly organized at a molecular level. Understanding how specific proteins localize to their proper subcellular address has been a major challenge in bacterial cell biology. One mechanism, which appears to be increasingly more common, is the use of 'geometric cues' for protein localization. In this model, certain shape-sensing proteins recognize, and preferentially embed into, either negatively or positively curved (concave or convex, respectively) membranes. Here, we review examples of bacterial proteins that reportedly localize by sensing geometric cues and highlight emerging mechanistic understandings of how proteins may recognize subtle differences in membrane curvature.
authors.affiliation: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Taylor B
authors.initials: TB
authors.lastname: Updegrove
authors.affiliation: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: ramamurthiks@mail.nih.gov.
authors.forename: Kumaran S
authors.initials: KS
authors.lastname: Ramamurthi
mesh_terms: D001419:Bacteria / Q000737:chemistry* / Q000166:cytology; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins