title: Lipoblastoma in children: Review of 12 cases.
abstract: BACKGROUND
  Lipoblastoma is a rare benign mesenchymal tumor of infancy and early childhood. Symptoms vary depending on localization, and signs of compression of adjacent organs may be seen.
  
  
  METHODS
  A total of 12 children with pathologically proven lipoblastoma from 2000 to 2014 were reviewed retrospectively for their clinical features, treatment and follow up.
  
  
  RESULTS
  There were seven boys and five girls between 7.5 months and 7.5 years of age. The most common symptom was painless rapid-growing mass. The tumors were located in the neck, the abdomen, the groin, pelvis, axilla, glutea, labium majus, thigh and trunk. The largest tumor was in a retroperitoneal location and was 13 × 10 cm in size. Complete resection was performed in 10 patients. All of these patients were followed without any evidence of recurrence. Subtotal excision was performed in two patients. At a median follow up of 38 months (range, 1.8 months-10 years), all patients were disease free.
  
  
  CONCLUSIONS
  Lipoblastoma should be considered in the differential diagnosis of rapidly growing mass in patients <3 years of age. Total excision is the treatment of choice with preservation of vital organs. The prognosis is excellent despite large tumor size and local invasion. Recurrence rate is high in incompletely resected tumors. Regular follow up is important for early detection of recurrence.
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hilal
authors.initials: H
authors.lastname: Susam-Sen
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Bilgehan
authors.initials: B
authors.lastname: Yalcin
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Tezer
authors.initials: T
authors.lastname: Kutluk
authors.affiliation: Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Feridun
authors.initials: F
authors.lastname: Cahit Tanyel
authors.affiliation: Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mithat
authors.initials: M
authors.lastname: Haliloglu
authors.affiliation: Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Diclehan
authors.initials: D
authors.lastname: Orhan
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Burca
authors.initials: B
authors.lastname: Aydin
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kurucu
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Varan
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Akyuz
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D062689:Lipoblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: adipose tumor; children; lipoblastoma