title: Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life.
abstract: OBJECTIVE
  To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years).
  
  
  METHODS
  None.
  
  
  METHODS
  Body mass index (BMI), waist circumference, blood pressure, glucose, insulin, cholesterol, lipoproteins, triglycerides and high-sensitivity C-reactive protein.
  
  
  RESULTS
  Both normo- and hyperandrogenic women with PCOS were more obese, especially abdominally. They had increased serum levels of insulin (fasting and in oral glucose tolerance tests), triglycerides, low-density lipoprotein, and total cholesterol, higher blood pressure, and lower high-density lipoprotein levels independently from BMI compared with the control population as early as from young adulthood until menopause. The prevalence of metabolic syndrome was two- to fivefold higher in women with PCOS compared with control women, depending on age and phenotype, and the highest prevalence was observed in hyperandrogenic women with PCOS at late reproductive age.
  
  
  CONCLUSIONS
  When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland; University of Oulu and Medical Research Center Oulu, Oulu, Finland.
authors.forename: Pekka
authors.initials: P
authors.lastname: Pinola
authors.affiliation: University of Oulu and Medical Research Center Oulu, Oulu, Finland; Nordlab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland.
authors.forename: Katri
authors.initials: K
authors.lastname: Puukka
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland; University of Oulu and Medical Research Center Oulu, Oulu, Finland.
authors.forename: Terhi T
authors.initials: TT
authors.lastname: Piltonen
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland; University of Oulu and Medical Research Center Oulu, Oulu, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Puurunen
authors.affiliation: Institute of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; Department of Obstetrics and Gynecology, St. Olav's University Hospital Trondheim, Trondheim, Norway.
authors.forename: Eszter
authors.initials: E
authors.lastname: Vanky
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: Inger
authors.initials: I
authors.lastname: Sundström-Poromaa
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Stener-Victorin
authors.affiliation: Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Angelica
authors.initials: A
authors.lastname: Lindén Hirschberg
authors.affiliation: Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark.
authors.forename: Pernille
authors.initials: P
authors.lastname: Ravn
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
authors.forename: Marianne
authors.initials: M
authors.lastname: Skovsager Andersen
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
authors.forename: Dorte
authors.initials: D
authors.lastname: Glintborg
authors.affiliation: Section of Reproductive Medicine, Department of Gynecology, Women's Division, Oslo University Hospital, Oslo, Norway.
authors.forename: Jan Roar
authors.initials: JR
authors.lastname: Mellembakken
authors.affiliation: University of Oulu and Medical Research Center Oulu, Oulu, Finland; Nordlab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland.
authors.forename: Aimo
authors.initials: A
authors.lastname: Ruokonen
authors.affiliation: University of Oulu and Medical Research Center Oulu, Oulu, Finland; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Juha S
authors.initials: JS
authors.lastname: Tapanainen
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland; University of Oulu and Medical Research Center Oulu, Oulu, Finland. Electronic address: lmp@cc.oulu.fi.
authors.forename: Laure C
authors.initials: LC
authors.lastname: Morin-Papunen
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology; D005260:Female; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000453:epidemiology; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D013058:Mass Spectrometry; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D055432:Metabolomics / Q000379:methods; D056128:Obesity, Abdominal / Q000453:epidemiology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D060728:Reproductive Health; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D013739:Testosterone / Q000097:blood / Q000172:deficiency; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D013739:Testosterone; D002097:C-Reactive Protein
keywords: PCOS; hyperandrogenism; metabolism; obesity