title: Registration and Summation of Respiratory-Gated or Breath-Hold PET Images Based on Deformation Estimation of Lung from CT Image.
abstract: Lung motion due to respiration causes image degradation in medical imaging, especially in nuclear medicine which requires long acquisition times. We have developed a method for image correction between the respiratory-gated (RG) PET images in different respiration phases or breath-hold (BH) PET images in an inconsistent respiration phase. In the method, the RG or BH-PET images in different respiration phases are deformed under two criteria: similarity of the image intensity distribution and smoothness of the estimated motion vector field (MVF). However, only these criteria may cause unnatural motion estimation of lung. In this paper, assuming the use of a PET-CT scanner, we add another criterion that is the similarity for the motion direction estimated from inhalation and exhalation CT images. The proposed method was first applied to a numerical phantom XCAT with tumors and then applied to BH-PET image data for seven patients. The resultant tumor contrasts and the estimated motion vector fields were compared with those obtained by our previous method. Through those experiments we confirmed that the proposed method can provide an improved and more stable image quality for both RG and BH-PET images.
authors.affiliation: Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan; Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
authors.forename: Hideaki
authors.identifier: 0000-0001-7157-4309
authors.initials: H
authors.lastname: Haneishi
authors.affiliation: Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanai
authors.affiliation: St. Hill Hospital, Ube 755-0155, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tamai
authors.affiliation: St. Hill Hospital, Ube 755-0155, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakohira
authors.affiliation: St. Hill Hospital, Ube 755-0155, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Suga
mesh_terms: D016477:Artifacts; D062485:Breath Holding; D003198:Computer Simulation; D003287:Contrast Media / Q000737:chemistry; D045853:Exhalation; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009038:Motion; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D012119:Respiration; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18