title: Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides.
abstract: A photoredox catalytic method has been developed for the direct C2 alkylation of pyridine N-oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2-alkylated pyridine N-oxides under mild conditions. Mechanistic studies are consistent with the generation of a radical intermediate along the reaction pathway.
authors.affiliation: School of Biological and Medical Engineering, Hefei University of Technology , Hefei 230009, China.
authors.forename: Wen-Man
authors.initials: WM
authors.lastname: Zhang
authors.affiliation: School of Biological and Medical Engineering, Hefei University of Technology , Hefei 230009, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Dai
authors.affiliation: School of Biological and Medical Engineering, Hefei University of Technology , Hefei 230009, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Biological and Medical Engineering, Hefei University of Technology , Hefei 230009, China.
authors.forename: Hua-Jian
authors.identifier: 0000-0002-0789-3484
authors.initials: HJ
authors.lastname: Xu