title: Left bundle branch block after sutureless, transcatheter, and stented biological aortic valve replacement for aortic stenosis.
abstract: OBJECTIVE
  Conventional aortic valve replacement (AVR), sutureless AVR (su-AVR) and transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) are associated with conduction abnormalities. The aim of the present study was to assess the incidence of left bundle branch block (LBBB) after su-AVR and TAVI, in comparison to conventional AVR.
  
  
  RESULTS
  A total of 501 patients (mean age 74±8 years, 53% male) without preoperative cardiac conduction disturbances who underwent AVR or TAVI were included in the study. Su-AVR patients and TAVI patients had a higher incidence of new-onset LBBB at hospital discharge (23% and 16%, respectively) compared to patients treated with conventional AVR (4%; p<0.001). On multivariate logistic regression analyses, the type of AVR was independently associated with complete LBBB, after correcting for age, preoperative QRS duration and heart rate (su-AVR and TAVI relative to the reference category conventional AVR: odds ratio [OR] 8.5, 95% confidence interval [CI]: 3.7-19.5; p<0.001, and OR 5.8, 95% CI: 2.4-14.1; p<0.001, respectively).
  
  
  CONCLUSIONS
  Su-AVR and TAVI were associated with higher risk of developing postoperative LBBB compared to conventional AVR, after adjusting for age, preoperative heart rate and QRS duration.
authors.affiliation: Heart Lung Center Leiden, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Madelien V
authors.initials: MV
authors.lastname: Regeer
authors.forename: Lisanne R
authors.initials: LR
authors.lastname: Merkestein
authors.forename: Arend
authors.initials: A
authors.lastname: de Weger
authors.forename: Vasileios
authors.initials: V
authors.lastname: Kamperidis
authors.forename: Frank
authors.initials: F
authors.lastname: van der Kley
authors.forename: Philippe J
authors.initials: PJ
authors.lastname: van Rosendael
authors.forename: Nina Ajmone
authors.initials: NA
authors.lastname: Marsan
authors.forename: Robert J M
authors.initials: RJ
authors.lastname: Klautz
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Schalij
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.forename: Victoria
authors.initials: V
authors.lastname: Delgado
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D001705:Bioprosthesis; D006328:Cardiac Catheterization / Q000379:methods; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors