title: [A Case of Giant Prostate Carcinoma Effectively Treated with External-Beam Radiation Therapy].
abstract: We present a case of gigantic prostate tumor in a patient with castration-resistant prostate cancer with successful local control by external-beam radiation therapy. A 71-year-old man was shown to have a prostate specific antigen (PSA)level of 24.5 ng/ml, Gleason 9, cT2N1M1a, prostate adenocarcinoma with an estimated prostate volume of 26.9 g. He achieved a PSA nadir at 4 months after the initial androgen deprivation therapy and was diagnosed with castration-resistant prostate cancer three years later. Eight months after the diagnosis of castration-resistant prostate cancer, he visited our hospital due to urinary retention. Abdominal computed tomography scan showed a gigantic prostatic mass occupying the whole pelvic cavity along with multiple lymph node, bone and liver metastases. The estimated volume of the prostate was 878 g. A tumor needle biopsy revealed a histological finding similar to the initial prostate biopsy which was adenocarcinoma with Gleason 9. He underwent external beam radiation therapy (60 Gy) to the prostate, which brought about excellent local control with a 96.7% shrinkage of tumor at 2 months after radiation therapy. He had no complaints of urinary symptoms and no need for urethral catheterization until he died of prostate cancer metastases.
authors.affiliation: The Department of Urology, Yuri Kumiai General Hospital.
authors.forename: Sohei
authors.initials: S
authors.lastname: Kanda
authors.affiliation: The Department of Urology, Akita University School of Medicine.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Narita
authors.affiliation: The Department of Urology, Yuri Kumiai General Hospital.
authors.forename: Naoki
authors.initials: N
authors.lastname: Komine
authors.affiliation: The Department of Urology, Yuri Kumiai General Hospital.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Kitajima
authors.affiliation: The Department of Pathology, Yuri Kumiai General Hospital.
authors.forename: Misa
authors.initials: M
authors.lastname: Yamauchi
authors.affiliation: The Department of Pathology, Yuri Kumiai General Hospital.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sugita
authors.affiliation: The Department of Radiology, Yuri Kumiai General Hospital.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.affiliation: The Department of Urology, Akita University School of Medicine.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D000368:Aged; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D061766:Proton Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D016055:Urinary Retention / Q000209:etiology