title: Molecular Targeted Therapy in Modern Oncology: Imaging Assessment of Treatment Response and Toxicities.
abstract: Oncology is a rapidly evolving field with a shift toward personalized cancer treatment. The use of therapies targeted to the molecular features of individual tumors and the tumor microenvironment has become much more common. In this review, anti-angiogenic and other molecular targeted therapies are discussed, with a focus on typical and atypical response patterns and imaging manifestations of drug toxicities.
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Krajewski
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Marta
authors.initials: M
authors.lastname: Braschi-Amirfarzan
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: DiPiro
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Jyothi P
authors.initials: JP
authors.lastname: Jagannathan
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Atul B
authors.initials: AB
authors.lastname: Shinagare
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000235:genetics; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents
keywords: Anaplastic lymphoma kinase; Epidermal growth factor receptor; Human epidermal growth factor receptor 2; Mammalian target of rapamycin; Response Evaluation Criteria in Solid Tumors; Vascular endothelial growth factor