title: Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal-Knorr Reaction.
abstract: A general and efficient method for accessing enantiomerically pure arylpyrroles by utilizing the catalytic asymmetric Paal-Knorr reaction has been developed for the first time. A wide range of axially chiral arylpyrroles were obtained in high yields with good to excellent enantioselectivities. The key to success is the use of the combined-acid catalytic system involving a Lewis acid and a chiral phosphoric acid for achieving effective enantiocontrol. Noteworthy is that an unexpected solvent-dependent inversion of the enantioselectivity was observed in the above-mentioned asymmetric reaction.
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.|Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University , Wuhan 430072, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Dao-Juan
authors.initials: DJ
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Bin
authors.identifier: 0000-0001-8219-9970
authors.initials: B
authors.lastname: Tan