title: Mild to moderate dysplasia at surgical margin is a significant indicator of survival in patients with oral cancer.
abstract: OBJECTIVE
  The objective of this study was to investigate the significance of mild and moderate dysplasia at the surgical margin with regard to survival and locoregional recurrence.
  
  
  METHODS
  We investigated cases of primary oral squamous cell carcinoma with negative margins retrospectively from the database of a tertiary cancer hospital. All patients had been treated between January 2010 and December 2012, and margin dysplasia was investigated in a multivariate analysis for locoregional recurrence and overall survival.
  
  
  RESULTS
  Of a total of 425 patients who fulfilled the inclusion criteria, 28 patients had mild dysplasia, and 29 patients had moderate dysplasia; median period of follow-up was 46.63 ± 10.04 (standard deviation) months. Most of the patients with mild and moderate dysplasia in the margin were tobacco users (P = .007). Univariate analysis showed lower rates of survival among the patients with margin dysplasia (mild + moderate) (P = .043), and the multivariate cox regression revealed moderate dysplasia at the margin as an independent significant factor for survival (P < .0001) when adjusted with other cofounders.
  
  
  CONCLUSIONS
  Patients with mild or moderate dysplasia at surgical margin were often tobacco users, and moderate dysplasia in the margin is an independent significant indicator for survival of patients with oral cancer in this single-institution, retrospective study.
authors.affiliation: Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India. Electronic address: sandhyagokavarapu@gmail.com.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Gokavarapu
authors.affiliation: Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
authors.forename: Nagendra
authors.initials: N
authors.lastname: Parvataneni
authors.affiliation: Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
authors.forename: Sreenivasa
authors.initials: S
authors.lastname: Pavagada
authors.affiliation: Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
authors.forename: L M
authors.initials: LM
authors.lastname: Chandrasekhara Rao
authors.affiliation: Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
authors.forename: K V
authors.initials: KV
authors.lastname: Raju
authors.affiliation: Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
authors.forename: T Subramaneshwar
authors.initials: TS
authors.lastname: Rao
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery*; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis