title: A clean photometric method for the determination of losartan potassium in pharmaceuticals exploiting light scattering effect and employing a multicommuted flow analysis approach.
abstract: This paper describes an environmentally friendly procedure for the determination of losartan potassium (Los-K) in pharmaceuticals. The photometric method was based on the light scattering effect due to particles suspension, which were formed by the reaction of Los-K with Cu (II) ions. The method was automated employing a multicommuted flow analysis approach, implemented using solenoid mini-pumps for fluid propelling and a homemade LED based photometer. Under the optimized experimental conditions, the procedure showed a linear relationship in the concentration range of 23.2-417.6mgL-1(r=0.9997, n=6), a relative standard deviation of 1.61% (n=10), a limit of detection (3.3*σ) estimated to be 12.1mgL-1, and a sampling rate of 140 determinations per hour. Each determination consumed 12µg of copper (II) acetate and generated 0.54mL of waste.
authors.affiliation: Centro de energia Nuclear na Agricultura - Universidade de São Paulo, Avenida Centenário, 303, CEP 13416-000 Piracicaba, SP, Brazil.
authors.forename: Manoel J A
authors.initials: MJA
authors.lastname: Lima
authors.affiliation: Centro de energia Nuclear na Agricultura - Universidade de São Paulo, Avenida Centenário, 303, CEP 13416-000 Piracicaba, SP, Brazil. Electronic address: reis@cena.usp.br.
authors.forename: Boaventura F
authors.initials: BF
authors.lastname: Reis
mesh_terms: D003300:Copper / Q000737:chemistry; D008027:Light; D019808:Losartan / Q000032:analysis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010783:Photometry / Q000379:methods*; D012542:Scattering, Radiation
chemical_list: D004364:Pharmaceutical Preparations; D003300:Copper; D019808:Losartan
keywords: Green chemistry; LED photometer; Losartan potassium; Multicommuted flow analysis; Pharmaceutical samples; Spectrophotometry