title: Bedside Contribution of Electrical Impedance Tomography to Setting Positive End-Expiratory Pressure for Extracorporeal Membrane Oxygenation-treated Patients with Severe Acute Respiratory Distress Syndrome.
abstract: Optimal positive end-expiratory pressure (PEEP) is unknown in patients with severe acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation receiving mechanical ventilation with very low tidal volume.
  
  
  
  To evaluate the ability of electrical impedance tomography (EIT) to monitor a PEEP trial and to derive from EIT the best compromise PEEP in this setting.
  
  
  
  A decremental PEEP trial (20-0 cm H2O) in 5 cm H2O steps was monitored by EIT, with lung images divided into four ventral-to-dorsal horizontal regions of interest. The EIT-based PEEP providing the best compromise between overdistention and collapsed zones was arbitrarily defined as the lowest pressure able to limit EIT-assessed collapse to less than or equal to 15% with the least overdistention. Driving pressure was maintained constant at 14 cm H2O in pressure controlled mode.
  
  
  
  Tidal volume, static compliance, tidal impedance variation, end-expiratory lung impedance, and their respective regional distributions were visualized at each PEEP level in 15 patients on extracorporeal membrane oxygenation. Low tidal volume (2.9-4 ml/kg ideal body weight) and poor compliance (12.1-18.7 ml/cm H2O) were noted, with significantly higher tidal volume and compliance at PEEP10and PEEP5than PEEP20. EIT-based best compromise PEEPs were 15, 10, and 5 cm H2O for seven, six, and two patients, respectively, whereas PEEP20and PEEP0were never selected.
  
  
  
  The broad variability in optimal PEEP observed in these patients with severe ARDS under extracorporeal membrane oxygenation reinforces the need for personalized titration of ventilation settings. EIT may be an interesting noninvasive bedside tool to provide real-time monitoring of the PEEP impact in these patients.
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Franchineau
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bréchot
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|3 Cardiac Surgery Department, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lebreton
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Hekimian
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Ania
authors.initials: A
authors.lastname: Nieszkowska
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Trouillet
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|3 Cardiac Surgery Department, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Leprince
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Jean
authors.initials: J
authors.lastname: Chastre
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Charles-Edouard
authors.initials: CE
authors.lastname: Luyt
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Alain
authors.initials: A
authors.lastname: Combes
authors.affiliation: 1 INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Université Pierre et Marie Curie Univ Paris 06, Paris, France; and.|2 Medical Intensive Care Unit and.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017097:Electric Impedance; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D019095:Point-of-Care Systems; D011175:Positive-Pressure Respiration / Q000379:methods*; D015203:Reproducibility of Results; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D013990:Tidal Volume; D014054:Tomography / Q000379:methods*; D055815:Young Adult
keywords: acute respiratory distress syndrome; electrical impedance tomography; extracorporeal membrane oxygenation; mechanical ventilation; positive end-expiratory pressure