title: Pharmacological Evaluation ofChrozophora tinctoriaas Wound Healing Potential in Diabetic Rat's Model.
abstract: Objective. The study was designed to evaluate pharmacological potential of hydroalcoholic leaves extract ofChrozophora tinctoriaintended for wound healing in diabetic rats' model.Methods. The method used to evaluate the pharmacological potential of hydroalcoholic leave extract was physical incision rat model. In this model, cutting of the skin and/or other tissues with a sharp blade has been made and the rapid disruption of tissue integrity with minimal collateral damage was observed shortly. Animals used in the study were divided into four groups that consist of six animals in each group. Group I serves as normal control, Group II serves as disease control, Group III was used as standard treatment (Povidone iodine 50 mg/kg b.w.), and Group IV was used for test drug (C. tinctoria50 mg/kg b.w.).Result. The hydroalcoholic leave extract ofChrozophora tinctoriahas been significantly observed to heal the wound (98%) in diabetic rats within 21 days, while standard drug (Povidone iodine) healed the wound about 95% in the same condition. The oral dose (50 mg/kg b.w.) ofChrozophora tinctoriawas also found to improve the elevated blood glucose level in comparison to disease control group, which increased after the oral administration of Streptozotocin.Conclusion.TheChrozophora tinctoriahas significant wound healing potential in the animal having physically damaged tissue in diabetic condition.
authors.affiliation: Siddhartha Institute of Pharmacy, Sahastradhara Road, Dobachi, Dehradun 248001, India.
authors.forename: Harikesh
authors.identifier: 0000-0002-6198-0909
authors.initials: H
authors.lastname: Maurya
authors.affiliation: Siddhartha Institute of Pharmacy, Sahastradhara Road, Dobachi, Dehradun 248001, India.
authors.forename: Monika
authors.initials: M
authors.lastname: Semwal
authors.affiliation: Siddhartha Institute of Pharmacy, Sahastradhara Road, Dobachi, Dehradun 248001, India.
authors.forename: Susheel Kumar
authors.initials: SK
authors.lastname: Dubey
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D013311:Streptozocin / Q000633:toxicity; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D013311:Streptozocin