title: Present and Future of Interventional Treatment of Resistant Hypertension.
abstract: The increasing prevalence of hypertension, a significant cause of disability and premature death throughout the world, is a major public health concern. This is especially true for the subset of patients who suffer from resistant hypertension, which is associated with a fourfold greater risk of cardiovascular events as compared to those hypertensive patients able to achieve target blood pressure. Though quite daunting in number and ill effect, hypertension remains the most common and the most important modifiable risk factor for coronary heart disease, congestive heart failure, peripheral vascular disease, stroke, and chronic kidney disease. Therefore, the ongoing development of novel therapies for the management of hypertension is of utmost importance. This review evaluates the present and future of interventional treatment of resistant hypertension, most of which remains investigational and warrants critical assessment.
authors.affiliation: University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Yoruk
authors.affiliation: University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Sinan S
authors.initials: SS
authors.lastname: Tankut
authors.affiliation: University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Gassler
authors.affiliation: University of Rochester Medical Center, Rochester, NY, USA. john_bisognano@urmc.rochester.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Bisognano
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic / Q000209:etiology; D012307:Risk Factors
keywords: Hypertension; Resistant hypertension; Sympathetic Nervous System