title: Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism.
abstract: According to the World Health Organization, around 20% of all cancers would be due to environmental factors. Among these factors, several chemicals are indeed well recognized carcinogens. The widespread contaminant benzo[a]pyrene (B[a]P), an often used model carcinogen of the polycyclic aromatic hydrocarbons' family, has been suggested to target most, if not all, cancer hallmarks described by Hanahan and Weinberg. It is classified as a group I carcinogen by the International Agency for Research on Cancer; however, the precise intracellular mechanisms underlying its carcinogenic properties remain yet to be thoroughly defined. Recently, the pH homeostasis, a well known regulator of carcinogenic processes, was suggested to be a key actor in both cell death and Warburg-like metabolic reprogramming induced upon B[a]P exposure. The present review will highlight those data with the aim of favoring research on the role of H+dynamics in environmental carcinogenesis.
authors.affiliation: Institut national de la santé et de la recherche médicale (Inserm), Institut de recherche en santé, environnement et travail (Irset - Inserm UMR 1085), F-35043 Rennes, France; Université de Rennes 1, Structure fédérative de recherche Biosit, UMS CNRS 3480/US Inserm 018, F 35043 Rennes, France.
authors.forename: Kévin
authors.initials: K
authors.lastname: Hardonnière
authors.affiliation: INRA UMR 1331 ToxAlim (Research Center in Food Toxicology), University of Toulouse ENVT, INP, UPS, 180 Chemin de Tournefeuille, F-31027, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Huc
authors.affiliation: Institut national de la santé et de la recherche médicale (Inserm), Institut de recherche en santé, environnement et travail (Irset - Inserm UMR 1085), F-35043 Rennes, France; Université de Rennes 1, Structure fédérative de recherche Biosit, UMS CNRS 3480/US Inserm 018, F 35043 Rennes, France.
authors.forename: Odile
authors.initials: O
authors.lastname: Sergent
authors.affiliation: Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Jørn A
authors.initials: JA
authors.lastname: Holme
authors.affiliation: Institut national de la santé et de la recherche médicale (Inserm), Institut de recherche en santé, environnement et travail (Irset - Inserm UMR 1085), F-35043 Rennes, France; Université de Rennes 1, Structure fédérative de recherche Biosit, UMS CNRS 3480/US Inserm 018, F 35043 Rennes, France. Electronic address: dominique.lagadic@univ-rennes1.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Lagadic-Gossmann
mesh_terms: D063646:Carcinogenesis; D002273:Carcinogens / Q000633:toxicity*; D004781:Environmental Exposure; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration
chemical_list: D002273:Carcinogens
keywords: Apoptosis; Benzo[a]pyrene; Na+/H+ exchanger; Warburg effect; pH and carcinogenesis