title: Encapsulation of lemongrass oil with cyclodextrins by spray drying and its controlled release characteristics.
abstract: Inclusion of the two isomers of citral (E-citral and Z-citral), components of lemongrass oil, was investigated within the confines of various cyclodextrin (α-CD, β-CD and γ-CD) host molecules. Aqueous complex formation constants for E-citral with α-CD, β-CD and γ-CD were determined to be 123, 185, and 204 L/mol, respectively, whereas Z-citral exhibited stronger affinities (157, 206, and 253 L/mol, respectively). The binding trend γ-CD > β-CD > α-CD is a reflection of the more favorable geometrical accommodation of the citral isomers with increasing cavity size. Encapsulation of lemongrass oil within CDs was undertaken through shaking citral:CD (1:1, 1.5:1, and 2:1 molar ratio) mixtures followed by spray drying. Maximum citral retention occurred at a 1:1 molar ratio with β-CD and α-CD demonstrating the highest levels of total E-citral and Z-citral retention, respectively. Furthermore, the β-CD complex demonstrated the slowest release rate of all inclusion complex powders.
authors.affiliation: a Faculty of Engineering, Department of Chemical Engineering , Chulalongkorn University , Bangkok , Thailand.|b National Nanotechnology Center, National Science and Technology Development Agency , Patumthani , Thailand.
authors.forename: Sarunya
authors.initials: S
authors.lastname: Phunpee
authors.affiliation: b National Nanotechnology Center, National Science and Technology Development Agency , Patumthani , Thailand.
authors.forename: Uracha Rangsadthong
authors.initials: UR
authors.lastname: Ruktanonchai
authors.affiliation: c Department of Applied Biological Science , Kagawa University , Kagawa , Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Yoshii
authors.affiliation: a Faculty of Engineering, Department of Chemical Engineering , Chulalongkorn University , Bangkok , Thailand.
authors.forename: Suttichai
authors.initials: S
authors.lastname: Assabumrungrat
authors.affiliation: a Faculty of Engineering, Department of Chemical Engineering , Chulalongkorn University , Bangkok , Thailand.
authors.forename: Apinan
authors.initials: A
authors.lastname: Soottitantawat
mesh_terms: D000080462:Acyclic Monoterpenes; D003505:Cyclodextrins / Q000737:chemistry*; D003890:Desiccation; D039821:Monoterpenes / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry*; D011208:Powders / Q000737:chemistry; D012995:Solubility; D013729:Terpenes / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000080462:Acyclic Monoterpenes; D003505:Cyclodextrins; D039821:Monoterpenes; D010938:Plant Oils; D011208:Powders; D013729:Terpenes; D014867:Water; C052901:lemongrass oil; C007076:citral
keywords: citral; cyclodextrins; inclusion complex; lemongrass oil; spray drying