title: [Acquired, non-amyloid related factor X deficiency: A first case associated with atypical chronic lymphocytic leukemia and literature review].
abstract: BACKGROUND
  Acquired factor X deficiency is in most cases associated with AL amyloidosis. Acquired non-amyloid related factor X deficiency (DNAA-FX) has been exceptionally reported in the literature.
  
  
  METHODS
  We report the first case of acquired, non-amyloid related factor X deficiency associated with atypical chronic lymphoid leukemia in a 66-year-old patient with spontaneous hematomas. After therapeutic failure with polyclonal intravenous immunoglobulins, specific lymphoid malignancy treatment allowed symptoms and coagulation disorder resolution.
  
  
  CONCLUSIONS
  DNAA-FX should be considered in case of bleeding events or coagulation disorders during low-grade hematological malignancies. Its occurrence can be considered as a treatment indication to prevent potentially fatal bleeding complications.
authors.affiliation: Service de médecine interne- oncologie, hôpital d'instruction des armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France; École du Val-de-Grâce, boulevard Port-Royal, 75005 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Boudin
authors.affiliation: Service de médecine interne- oncologie, hôpital d'instruction des armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France; École du Val-de-Grâce, boulevard Port-Royal, 75005 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Patient
authors.affiliation: Service de médecine interne- oncologie, hôpital d'instruction des armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France.
authors.forename: E
authors.initials: E
authors.lastname: Roméo
authors.affiliation: Service de médecine interne- oncologie, hôpital d'instruction des armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France.
authors.forename: J-S
authors.initials: JS
authors.lastname: Bladé
authors.affiliation: Service de médecine interne- oncologie, hôpital d'instruction des armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France.
authors.forename: O
authors.initials: O
authors.lastname: Gisserot
authors.affiliation: Service de médecine interne- oncologie, hôpital d'instruction des armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France; École du Val-de-Grâce, boulevard Port-Royal, 75005 Paris, France. Electronic address: oncologie@sainteanne.org.
authors.forename: J-P
authors.initials: JP
authors.lastname: de Jauréguiberry
mesh_terms: D000368:Aged; D005171:Factor X Deficiency / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male
keywords: Acquired factor X deficiency; Chronic lymphocytic leukemia; Déficit acquis en facteur X; Hémopathie lymphoïde; Leucémie lymphoïde chronique; Lymphoid malignancies