title: Distant spread of a supratentorial glioblastoma to the spinal cord.
abstract: Extracranial spread from a glioblastoma is rare. We present a case of a 48year-old man with a previously radiologically-stable left temporal lobe glioblastoma presenting with symptoms referrable to the spinal cord. MRI revealed a spinal cord lesion, with the differential including transverse myelitis and tumour. Open surgical biopsy revealed high-grade astrocytoma. Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour.
authors.affiliation: Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Krishnan
authors.initials: K
authors.lastname: Ravindran
authors.affiliation: Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Radiology, The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Frank
authors.initials: F
authors.lastname: Gaillard
authors.affiliation: Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Monash Imaging, Monash Health, Clayton, VIC, Australia. Electronic address: arian.lasocki@petermac.org.
authors.forename: Arian
authors.initials: A
authors.lastname: Lasocki
mesh_terms: D005909:Glioblastoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D015173:Supratentorial Neoplasms / Q000175:diagnosis* / Q000473:pathology
keywords: Extra-cranial; Glioblastoma; Metastasis; Spinal