title: Altered Liver Proteoglycan/Glycosaminoglycan Structure as a Manifestation of Extracellular Matrix Remodeling upon BCG-induced Granulomatosis in Mice.
abstract: Experimental BCG-induced granulomatosis in mice was used to study changes in the dynamics of individual liver proteoglycan components reflecting phasic extracellular matrix remodeling, determined by the host-parasite interaction and associated with granuloma development. In the early BCG-granulomatosis period, the increase in individual proteoglycan components promotes granuloma formation, providing conditions for mycobacteria adhesion to host cells, migration of phagocytic cells from circulation, and cell-cell interaction leading to granuloma development and fibrosis. Later, reduced reserve capacity of the extracellular matrix, development of interstitial fibrosis and granuloma fibrosis can lead to trophic shortage for cells within the granulomas, migration of macrophages out of them, and development of spontaneous necrosis and apoptosis typical of tuberculosis.
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia. lenkim@centercem.ru.
authors.forename: L B
authors.initials: LB
authors.lastname: Kim
authors.affiliation: Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.|Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupy
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Putyatina
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000096:biosynthesis* / Q000737:chemistry; D006099:Granuloma / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D022781:Hepatocytes / Q000737:chemistry / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D054884:Host-Pathogen Interactions; D008099:Liver / Q000737:chemistry / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000472:pathogenicity / Q000502:physiology; D011509:Proteoglycans / Q000096:biosynthesis* / Q000737:chemistry; D014386:Tuberculosis, Hepatic / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology
chemical_list: D006025:Glycosaminoglycans; D011509:Proteoglycans
keywords: liver; mouse; proteoglycans/glycosaminoglycans; remodeling of extracellular matrix; tuberculous granulomatosis