title: 3D bioprinting and its in vivo applications.
abstract: The purpose of 3D bioprinting technology is to design and create functional 3D tissues or organs in situ for in vivo applications. 3D cell-printing, or additive biomanufacturing, allows the selection of biomaterials and cells (bioink), and the fabrication of cell-laden structures in high resolution. 3D cell-printed structures have also been used for applications such as research models, drug delivery and discovery, and toxicology. Recently, numerous attempts have been made to fabricate tissues and organs by using various 3D printing techniques. However, challenges such as vascularization are yet to be solved. This article reviews the most commonly used 3D cell-printing techniques with their advantages and drawbacks. Furthermore, up-to-date achievements of 3D bioprinting in in vivo applications are introduced, and prospects for the future of 3D cell-printing technology are discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 444-459, 2018.
authors.affiliation: Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
authors.forename: Nhayoung
authors.initials: N
authors.lastname: Hong
authors.affiliation: Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
authors.forename: Gi-Hoon
authors.initials: GH
authors.lastname: Yang
authors.affiliation: Department of Food Science and Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
authors.forename: JaeHwan
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
authors.forename: GeunHyung
authors.initials: G
authors.lastname: Kim
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000295:instrumentation / Q000379:methods; D062028:Bioprinting / Q000295:instrumentation / Q000379:methods; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D006801:Humans; D066330:Printing, Three-Dimensional / Q000295:instrumentation*
keywords: 3D bioprinting; clinical application; tissue engineering