title: Thermodynamic and Kinetic Stabilities of G-Quadruplexes in Apolar Solvents.
abstract: In contrast to more polar media, G-quadruplex assembly reveals remarkably high thermodynamic and kinetic stability in toluene solutions. Depending on the substituents installed at the lipophilic guanosine, either a dodecamer or an octamer complex is formed in the presence of K+or Na+salts that resist conditions of high dilution and elevated temperatures without exhibiting significant dissociation. Moreover, kinetic exchange between complexed and uncomplexed G is slow enough in NMR to monitor G-quadruplex formation along a day time scale.
authors.affiliation: Organic Chemistry Department, Universidad Autónoma de Madrid , 28049 Madrid, Spain.|Department of Chemistry, Sharif University of Technology , P.O. Box 11155-9516, Tehran, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Fadaei
authors.affiliation: Organic Chemistry Department, Universidad Autónoma de Madrid , 28049 Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Martín-Arroyo
authors.affiliation: Department of Chemistry, Sharif University of Technology , P.O. Box 11155-9516, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Tafazzoli
authors.affiliation: Organic Chemistry Department, Universidad Autónoma de Madrid , 28049 Madrid, Spain.|Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid , 28049 Madrid, Spain.
authors.forename: David
authors.identifier: 0000-0002-2651-4566
authors.initials: D
authors.lastname: González-Rodríguez