title: Chemical and structural effects of base modifications in messenger RNA.
abstract: A growing number of nucleobase modifications in messenger RNA have been revealed through advances in detection and RNA sequencing. Although some of the biochemical pathways that involve modified bases have been identified, research into the world of RNA modification - the epitranscriptome - is still in an early phase. A variety of chemical tools are being used to characterize base modifications, and the structural effects of known base modifications on RNA pairing, thermodynamics and folding are being determined in relation to their putative biological roles.
authors.affiliation: Department of Chemistry, Wellesley College, Wellesley, Massachusetts 02481, USA.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Harcourt
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305, USA.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Kietrys
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305, USA.
authors.forename: Eric T
authors.initials: ET
authors.lastname: Kool
mesh_terms: D000818:Animals; D006801:Humans; D013058:Mass Spectrometry; D015394:Molecular Structure; D012333:RNA, Messenger / Q000032:analysis* / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017423:Sequence Analysis, RNA; D059467:Transcriptome / Q000235:genetics
chemical_list: D012333:RNA, Messenger