title: Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism.
abstract: To evaluate the microRNA-219 and NMDA expression in brain tissue and blood of animals subjected to cerebral ischemia associated with alcoholism.
  Fifty Wistar rats were divided into groups: control, sham, ischemic, alcoholic, and ischemic plus alcoholic. The expression of microRNA-219 and NMDA were analyzed by real-time PCR.
  When compared to the control group, the microRNA-219 in brain tissue was less expressed in the ischemic, alcoholic, and ischemic plus alcoholic groups. In the blood, this microRNA had lower expression in alcoholic and ischemic plus alcoholic groups. In the brain tissue the NMDA gene expression was greater in the ischemic, alcoholic, and ischemic plus alcoholic groups.
  A possible modulation of NMDA by microRNA-219 was observed with an inverse correlation between them.
authors.affiliation: Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil.
authors.forename: Cristiane Iozzi
authors.initials: CI
authors.lastname: Silva
authors.affiliation: Universidade de Marília, Departamento de Odontologia, Marília SP, Brasil.
authors.forename: Paulo Cézar
authors.initials: PC
authors.lastname: Novais
authors.affiliation: Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil.
authors.forename: Andressa Romualdo
authors.initials: AR
authors.lastname: Rodrigues
authors.affiliation: Universidade Federal de Alagoas, Instituto de Ciências Biológicas e da Saúde, Maceió AL, Brasil.
authors.forename: Camila A M
authors.initials: CA
authors.lastname: Carvalho
authors.affiliation: Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil.
authors.forename: Benedicto Oscar
authors.initials: BO
authors.lastname: Colli
authors.affiliation: Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil.
authors.forename: Carlos Gilberto
authors.initials: CG
authors.lastname: Carlotti
authors.affiliation: Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil.
authors.forename: Luís Fernando
authors.initials: LF
authors.lastname: Tirapelli
authors.affiliation: Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil.
authors.forename: Daniela P C
authors.initials: DP
authors.lastname: Tirapelli
mesh_terms: D000437:Alcoholism / Q000150:complications*; D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: C000591851:MIRN219 microRNA, rat; D035683:MicroRNAs; D016194:Receptors, N-Methyl-D-Aspartate