title: Postocclusive Hyperemia Measured with Laser Doppler Flowmetry and Transcutaneous Oxygen Tension in the Diagnosis of Primary Raynaud's Phenomenon: A Prospective, Controlled Study.
abstract: The aim of this study was to measure the sensitivity and specificity of transcutaneous oxygen tension and postocclusive hyperemia testing using laser Doppler flowmetry in patients with primary Raynaud's phenomenon. One hundred patients and one hundred controls were included in the study. Baseline microvascular blood flow and then time to peak flow following occlusion were measured using laser Doppler flowmetry. Afterwards, the transcutaneous oxygen tension was recorded. The sensitivities of baseline microvascular blood flow, postocclusive time to peak flow, and transcutaneous oxygen tension were 79%, 79%, and 77%, respectively. The postocclusive time peak flow had a superior specificity of 90% and area under the curve of 0.92 as compared to 66% and 0.80 for baseline microvascular flow and 64% and 0.76 for transcutaneous oxygen tension. Time to postocclusive peak blood flow measured by laser Doppler flowmetry is a highly accurate test for differentiating patients with primary Raynaud's phenomenon from healthy controls.
authors.affiliation: Department of Angiology, Jagiellonian University Medical College, 8 Skawińska Street, 31-066 Krakow, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Maga
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, 12 Kopernika Street, 31-034 Krakow, Poland.
authors.forename: Brandon Michael
authors.initials: BM
authors.lastname: Henry
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, 12 Kopernika Street, 31-034 Krakow, Poland.
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Kmiotek
authors.affiliation: Department of Pediatric Dentistry, Institute of Dentistry, Jagiellonian University Medical College, 4 Montelupich Street, 31-155 Krakow, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Gregorczyk-Maga
authors.affiliation: Department of Angiology, Jagiellonian University Medical College, 8 Skawińska Street, 31-066 Krakow, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Kaczmarczyk
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, 12 Kopernika Street, 31-034 Krakow, Poland.
authors.forename: Krzysztof A
authors.identifier: 0000-0001-5077-6948
authors.initials: KA
authors.lastname: Tomaszewski
authors.affiliation: Department of Angiology, Jagiellonian University Medical College, 8 Skawińska Street, 31-066 Krakow, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Niżankowski
mesh_terms: D000293:Adolescent; D000328:Adult; D001785:Blood Gas Monitoring, Transcutaneous / Q000379:methods; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000097:blood / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011928:Raynaud Disease / Q000097:blood / Q000503:physiopathology