title: A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib.
abstract: A 39-year-old man treated with dasatinib for chronic myelogenous leukaemia presented to our hospital with haemoptysis, coughing, and dyspnoea. Chest radiography and computed tomography revealed ground-glass opacities and a crazy-paving pattern. Bronchoalveolar lavage was not performed due to serious hypoxemia and bleeding. Significant bleeding from the peripheral bronchi led to a diagnosis of an alveolar haemorrhage. Dasatinib-induced alveolar haemorrhaging was suspected based on the clinical findings. His condition improved immediately after dasatinib withdrawal and initiation of steroid therapy. Reports of alveolar haemorrhaging induced by dasatinib are rare. As such, this is considered an important case.
authors.affiliation: Department of Respiratory Medicine, St. Mary's Hospital, Japan.
authors.forename: Yoritake
authors.initials: Y
authors.lastname: Sakoda
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Arimori
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ueno
authors.forename: Takafumi
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D003371:Cough / Q000209:etiology; D000069439:Dasatinib / Q000009:adverse effects / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000209:etiology; D006470:Hemorrhage / Q000139:chemically induced / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011649:Pulmonary Alveolar Proteinosis / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D047428:Protein Kinase Inhibitors; D000069439:Dasatinib