title: Technical characterization of dialysis fluid flow and mass transfer rate in dialyzers with various filtration coefficients using dimensionless correlation equation.
abstract: The objective of the present study is to evaluate the effect of filtration coefficient and internal filtration on dialysis fluid flow and mass transfer coefficient in dialyzers using dimensionless mass transfer correlation equations. Aqueous solution of vitamin B12clearances were obtained for REXEED-15L as a low flux dialyzer, and APS-15EA and APS-15UA as high flux dialyzers. All the other design specifications were identical for these dialyzers except for filtration coefficient. The overall mass transfer coefficient was calculated, moreover, the exponents of Reynolds number (Re) and film mass transfer coefficient of the dialysis-side fluid (kD) for each flow rate were derived from the Wilson plot and dimensionless correlation equation. The exponents of Re were 0.4 for the low flux dialyzer whereas 0.5 for the high flux dialyzers. Dialysis fluid of the low flux dialyzer was close to laminar flow because of its low filtration coefficient. On the other hand, dialysis fluid of the high flux dialyzers was assumed to be orthogonal flow. Higher filtration coefficient was associated with higher kDinfluenced by mass transfer rate through diffusion and internal filtration. Higher filtration coefficient of dialyzers and internal filtration affect orthogonal flow of dialysis fluid.
authors.affiliation: Department of Biomedical Engineering, Kindai University, 930 Nishimitani, Kinokawa, Wakayama, 649-6493, Japan. fukuda@waka.kindai.ac.jp.
authors.forename: Makoto
authors.identifier: http://orcid.org/0000-0002-3776-6662
authors.initials: M
authors.lastname: Fukuda
authors.affiliation: Department of Biomedical Engineering, Kindai University, 930 Nishimitani, Kinokawa, Wakayama, 649-6493, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshimura
authors.affiliation: Department of Medical Engineering, Junshin Gakuen University, Fukuoka, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Namekawa
authors.affiliation: Chemical Engineering, Waseda University, Tokyo, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Sakai
mesh_terms: D015314:Dialysis Solutions; D005374:Filtration; D006801:Humans; D008567:Membranes, Artificial; D008954:Models, Biological; D010539:Permeability; D006435:Renal Dialysis
chemical_list: D015314:Dialysis Solutions; D008567:Membranes, Artificial
keywords: Dimensionless correlation equation; Hollow fiber membrane; Mass transfer; Reynolds number; Wilson plot