title: Blood malignancies presenting with mutations at equivalent residues in RUNX1-2 suggest a common leukemogenic pathway.
authors.affiliation: a Unit of Dentistry , Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Callea
authors.affiliation: b Unit for Neuromuscular and Neurodegenerative Disorders, Laboratory of Molecular Medicine , Bambino Gesù Children's Hospital , Rome , Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Fattori
authors.affiliation: b Unit for Neuromuscular and Neurodegenerative Disorders, Laboratory of Molecular Medicine , Bambino Gesù Children's Hospital , Rome , Italy.
authors.forename: Enrico Silvio
authors.initials: ES
authors.lastname: Bertini
authors.affiliation: c Department of Pediatrics, Unit of Medical Genetics, Faculty of Medicine , University of The Andes , Mérida , Venezuela.
authors.forename: Francisco
authors.initials: F
authors.lastname: Cammarata-Scalisi
authors.affiliation: d Department of Pathology , Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Callea
authors.affiliation: e Research Laboratories, Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Bellacchio
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D050659:Core Binding Factor Alpha 1 Subunit / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D050676:Core Binding Factor Alpha 2 Subunit / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D011485:Protein Binding; D011487:Protein Conformation; D054730:Protein Interaction Domains and Motifs; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit; D050676:Core Binding Factor Alpha 2 Subunit; C493728:RUNX1 protein, human; C493709:RUNX2 protein, human