title: SnoRNAs are involved in the progression of ulcerative colitis and colorectal cancer.
abstract: OBJECTIVE
  Emerging evidences indicate that small nucleolar RNAs (snoRNAs) are important regulatory molecules involved in various pathophysiological processes including inflammation and cancer. In the current study, we investigate whether snoRNAs dysregulate in colorectal cancer (CRC) and intestinal inflammation and contribute the pathogenesis of CRC.
  
  
  METHODS
  We analyzed the snoRNAs expression profile in CRC patients by GeneChipR Array and validated candidate snoRNAs expression in 44 CRC tissues, as well as in 28 ulcerative colitis (UC) and 28 healthy controls using reverse transcription quantitative polymerase chain reaction. Furthermore, we analyzed the correlation between snoRNAs expression and clinical characteristics of CRC and evaluated the diagnosis and differentiation efficiencies of the snoRNAs in CRC and UC.
  
  
  RESULTS
  The expression of snoRA15, snoRA41 displayed increased, whereas snoRD33 was down-regulated in CRC compared with matched non-cancerous tissues. When compared to healthy control, the three snoRNAs are all upregulated in lesion tissue of UC and CRC, which showed an increasingly trend from healthy control to UC and CRC.
  
  
  CONCLUSIONS
  The identified three snoRNAs might contribute the carcinogenesis of colorectal cancer and involve in the progress from chronic intestinal inflammation to malignant tumor.
authors.affiliation: Gastroenterology Division, Geriatrics Department, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.affiliation: Gastroenterology Division, Geriatrics Department, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Life Sciences, Wuhan University, Wuhan, Hubei 430071, China.
authors.forename: Lianyun
authors.initials: L
authors.lastname: Li
authors.affiliation: Gastroenterology Division, Geriatrics Department, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Life Sciences, Wuhan University, Wuhan, Hubei 430071, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: Gastroenterology Division, Geriatrics Department, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China. Electronic address: wumeiye08@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Ye
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003093:Colitis, Ulcerative / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged; D015999:Multivariate Analysis; D020537:RNA, Small Nucleolar / Q000235:genetics*; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D020537:RNA, Small Nucleolar
keywords: Biomarkers; Colorectal cancer; IBD; SnoRNAs