title: Effects of Rosuvastatin Alone or in Combination with Omega-3 Fatty Acid on Adiponectin Levels and Cardiometabolic Profile.
abstract: BACKGROUND
  Adiponectin is an important adipocyte-related protein that has been postulated to participate in prevention of the development of metabolic syndrome. The relationship between adiponectin serum levels and risk of coronary artery disease (CAD) has been widely investigated and remains controversial. The aim of the present study was to evaluate the effects of rosuvastatin and/or omega-3 fatty acid on adiponectin serum levels in patients with insulin resistance (IR) and CAD.
  
  
  METHODS
  This study involved 87 patients with CADs and IR of different etiology, the patients were divided into three groups; 24 patients on treatment with rosuvastatin, 22 patients on treatment with omega-3 fatty acid, 23 patients on treatment with omega-3 fatty acid and rosuvastatin, 18 patients were not previously or currently treated with either rosuvastatin or omega-3 fatty acid, those regarded as control patients. Anthropometric measures, adiponectin serum levels, and other biochemical parameters were assessed in each treated group.
  
  
  RESULTS
  Rosuvastatin therapy leads to a significant elevation in adiponectin serum levels from 4.1 ± 0.99 ng/mL to 6.76 ± 1.03 ng/mL compared to controlP< 0.01. Omega-3 fatty acid therapy leads to a significant elevation in adiponectin serum levels from 4.1 ± 0.99 ng/mL to 6.11 ± 1.29 ng/mL compared to controlP< 0.01. Rosuvastatin plus omega-3 fatty acid therapy lead to a significant elevation in adiponectin serum levels from 4.1 ± 0.99 ng/mL to 7.99 ± 1.76 ng/mL compared to controlP< 0.01.
  
  
  CONCLUSIONS
  Rosuvastatin and/or omega-3 fatty acid lead to significant cardiometabolic protection through an increment in adiponectin serum levels.
authors.affiliation: Department of Pharmacology, Toxicology and Medicine, College of Medicine, AlMustansiriya University, Baghdad, Iraq.
authors.forename: Hayder M
authors.initials: HM
authors.lastname: Al-Kuraishy
authors.affiliation: Department of Pharmacology, Toxicology and Medicine, College of Medicine, AlMustansiriya University, Baghdad, Iraq.
authors.forename: Ali I
authors.initials: AI
authors.lastname: Al-Gareeb
keywords: Adiponectin; omega-3 fatty acid; rosuvastatin