title: MRI, Retrieval Analysis, and Histologic Evaluation of Adverse Local Tissue Reaction in Metal-on-Polyethylene Total Hip Arthroplasty.
abstract: The severity and location of adverse local tissue reaction (ALTR) seen in metal-on-polyethylene total hip arthroplasty (THA) is not well described.
  
  
  
  We retrospectively reviewed the records of patients who underwent a revision THA using our biomechanics database. We included all patients who underwent revision surgery for the diagnosis of ALTR with THA implants that had modularity solely at the head-neck junction and excluded patients with implant modularity at sites other than the head-neck junction. Magnetic resonance imaging (MRI) was evaluated by a fellowship-trained radiologist who specializes in evaluating metal artifact reducing MRI sequences to quantify the ALTR lesions. Histology was evaluated for findings of ALTR using the Campbell score.
  
  
  
  We identified 11 patients in the database. Eight patients had an MRI ALTR grade of severe and 7 did based on the histology score. The mean synovial volume was 218,658 mm3(range 23,461-451,435 mm3) with a mean maximal synovial thickness of 15.3 mm (range 3-34.3 mm). A disruptive infiltration of the abductors due to pseudocapsule invasion was seen in 67% of the patients with 3 not having abductor involvement. Mean preoperative cobalt and chromium levels were 5.4 ppb (range 1-12.3 ppb) and 1.1 ppb (range 0.6-2.4 ppb), respectively.
  
  
  
  Patients with ALTR from head-neck junction corrosion in metal-on-polyethylene THA may present with large pseudotumors that have previously been under appreciated. Mean preoperative serum cobalt and chromium ion levels remained relatively low, and MRI was an effective way to characterize the size and location of these lesions.
authors.affiliation: Department of Orthopaedics, Hospital for Special Surgery, New York, New York.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Nodzo
authors.affiliation: Department of Biomechanics, Hospital for Special Surgery, New York, New York.
authors.forename: Christina I
authors.initials: CI
authors.lastname: Esposito
authors.affiliation: Department of Radiology, Hospital for Special Surgery, New York, New York.
authors.forename: Hollis G
authors.initials: HG
authors.lastname: Potter
authors.affiliation: Department of Orthopaedics, Hospital for Special Surgery, New York, New York.
authors.forename: Chitranjan S
authors.initials: CS
authors.lastname: Ranawat
authors.affiliation: Department of Biomechanics, Hospital for Special Surgery, New York, New York.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Wright
authors.affiliation: Department of Orthopaedics, Hospital for Special Surgery, New York, New York.
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Padgett
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D002857:Chromium / Q000097:blood; D003035:Cobalt / Q000097:blood; D003343:Corrosion; D005260:Female; D005549:Foreign-Body Reaction / Q000175:diagnosis; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008670:Metals / Q000097:blood; D008875:Middle Aged; D020959:Polyethylene / Q000737:chemistry*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D008670:Metals; D002857:Chromium; D003035:Cobalt; D020959:Polyethylene
keywords: adverse local tissue reaction; magnetic resonance imaging; pseudotumor; total hip arthroplasty; tribocorrosion