title: Germinal Center Lymphocyte Ratios and Successful HIV Vaccines.
abstract: Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.
authors.affiliation: Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
authors.forename: Paula
authors.initials: P
authors.lastname: Gonzalez-Figueroa
authors.affiliation: Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Roco
authors.affiliation: Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia. Electronic address: carola.vinuesa@anu.edu.au.
authors.forename: Carola G
authors.initials: CG
authors.lastname: Vinuesa
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000627:therapeutic use; D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D018858:Germinal Center / Q000276:immunology* / Q000821:virology; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000821:virology; D008253:Macaca mulatta; D054299:env Gene Products, Human Immunodeficiency Virus / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D054299:env Gene Products, Human Immunodeficiency Virus