title: Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.
abstract: Background light intensity (irradiance) substantially impacts the visual code in the early visual system at synaptic and single-neuron levels, but its influence on population activity is largely unexplored. We show that fast narrowband oscillations, an important feature of population activity, systematically increase in amplitude as a function of irradiance in both anesthetized and awake, freely moving mice and at the level of the retina and dorsal lateral geniculate nucleus (dLGN). Narrowband coherence increases with irradiance across large areas of the dLGN, but especially for neighboring units. The spectral sensitivity of these effects and their substantial reduction in melanopsin knockout animals indicate a contribution from inner retinal photoreceptors. At bright backgrounds, narrowband coherence allows pooling of single-unit responses to become a viable strategy for enhancing visual signals within its frequency range.
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK. Electronic address: riccardo.storchi@manchester.ac.uk.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Storchi
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bedford
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK.
authors.forename: Franck P
authors.initials: FP
authors.lastname: Martial
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK.
authors.forename: Annette E
authors.initials: AE
authors.lastname: Allen
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Wynne
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK.
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Montemurro
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK.
authors.forename: Rasmus S
authors.initials: RS
authors.lastname: Petersen
authors.affiliation: Faculty of Life Sciences, University of Manchester, M13 9PT Manchester, UK.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lucas
mesh_terms: D000818:Animals; D004596:Electroretinography; D065818:Gamma Rhythm; D005829:Geniculate Bodies / Q000502:physiology*; D008027:Light; D051379:Mice; D018345:Mice, Knockout; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D017299:Rod Opsins / Q000235:genetics; D014785:Vision, Ocular / Q000502:physiology*; D014795:Visual Pathways; D014851:Wakefulness; D000099210:Melanopsin
chemical_list: D017299:Rod Opsins; D000099210:Melanopsin
keywords: dorsal lateral geniculate nucleus; freely moving extracellular recordings; intrinsically photosensitive retinal ganglion cells; irradiance; melanopsin; metameric light stimuli; narrowband gamma oscillations; neural population coding; receptor silent substitution; retina