title: Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges.
abstract: Given the increasing evidence indicates that many pathological conditions are associated with elevated reactive oxygen species (ROS) levels, there have been growing research efforts focused on the development of ROS-responsive carrier systems because of their promising potential to realize more specific diagnosis and effective therapy. By judicious utilization of ROS-responsive functional moieties, a wide range of carrier systems has been designed for ROS-mediated drug delivery. In this review article, insights into design principle and recent advances on the development of ROS-responsive carrier systems for drug delivery applications are provided alongside discussion of their in vitro and in vivo evaluation. In particular, the discussions in this article will mainly focus on polymeric nanoparticles, hydrogels, inorganic nanoparticles, and activatable prodrugs that have been integrated with diverse ROS-responsive moieties for spatiotemporally controlled release of drugs for effective therapy.
authors.affiliation: Center for Self-Assembly and Complexity Institute for Basic Science (IBS) Pohang 37673 Republic of Korea.
authors.forename: Gurusamy
authors.initials: G
authors.lastname: Saravanakumar
authors.affiliation: Center for Self-Assembly and Complexity Institute for Basic Science (IBS) Pohang 37673 Republic of Korea.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Center for Self-Assembly and Complexity Institute for Basic Science (IBS) Pohang 37673 Republic of Korea; Department of Chemistry Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea.
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Kim
keywords: drug delivery; hydrogels; inorganic nanoparticles; polymeric nanoparticles; prodrugs; reactive oxygen species