title: N-terminal truncated carboxypeptidase E expression is associated with poor prognosis of lung adenocarcinoma.
abstract: Lung cancer is a malignant tumor with high morbidity and mortality rates. To date, no suitable molecular diagnostic tool to predict disease recurrence and metastasis has been identified. The current study aimed to evaluate the potential of N-terminal truncated carboxypeptidase E (CPEΔN) to predict the recurrence and metastasis of lung adenocarcinoma. Western blotting revealed the co-expression of CPE and CPEΔN in the surgically collected pathological and pericarcinoma tissues tissues of 62.1% (59/95) lung adenocarcinoma patients. The full length CPE protein was predominantly expressed in pericarcinoma tissues and CPEΔN expression was identified in the pericarcinoma normal tissues of only 5.26% (5/95) patients. The 3-year postoperative recurrence and metastasis rates were significantly higher in patients with positive CPEΔN expression than in patients with negative CPEΔN expression (P=0.009). Furthermore, the overall survival rate of patients with predominant nuclear CPE expression was lower than that of patients with predominant cytoplasmic CPE expression (46.3 vs. 64.7%); however, no statistically significant difference was identified (P=0.125). Thus, the results of the current study indicated that CPEΔN may present a novel molecular biomarker for predicting recurrence and metastasis of lung adenocarcinoma, which may aid with stratifying patients by risk and thus, may facilitate individualized therapy.
authors.affiliation: Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Jinqiu Hospital of Liaoning Province, Shenyang, Liaoning 110016, P.R. China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Meng
authors.affiliation: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Molecular Oncology Laboratory, Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of General Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China.
authors.forename: Yunji
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
authors.forename: Hongyue
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Yu
authors.affiliation: Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
authors.forename: Tiemin
authors.initials: T
authors.lastname: Sun
authors.affiliation: Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
authors.forename: Aibing
authors.initials: A
authors.lastname: Qu
authors.affiliation: Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Jinqiu Hospital of Liaoning Province, Shenyang, Liaoning 110016, P.R. China.
authors.forename: Jimin
authors.initials: J
authors.lastname: Bao
authors.affiliation: Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
authors.forename: Guirong
authors.initials: G
authors.lastname: Zhang
keywords: N-terminal truncated carboxypeptidase E; disease-free survival; lung adenocarcinoma; overall survival; prognosis