title: A target oriented expeditious approach towards synthesis of certain bacterial rare sugar derivatives.
abstract: Bacterial rare amino deoxy sugars are found in the cell surface polysaccharides of multiple pathogenic bacterial strains, but are absent in the human metabolism. This helps in the differentiation between pathogens and host cells which can be exploited for target specific drug discovery and carbohydrate based vaccine development. The principal bacterial atypical sugar derivatives include 2-acetamido-4-amino-2,4,6-trideoxy-d-galactose (AAT), 2,4-diacetamido-2,4,6-trideoxy-d-galactose (DATDG) and N-acetylfucosamine (FucNAc). Herein, a highly streamlined protocol leading to the aforesaid derivatives is presented. The highlights of the method lie in radical mediated 6-deoxygenation along with a one-pot like protection profile manipulation on suitably derivatised d-glucosamine or d-mannose motifs to obtain a vital quinovosaminoside or rhamnoside from which rare sugar derivatives were synthesized in a diversity oriented manner.
authors.affiliation: Department of Chemistry, Jadavpur University, 188, Raja, S. C. Mullick Road, Kolkata-700 032, India. ghoshrina@yahoo.com.
authors.forename: Aritra
authors.initials: A
authors.lastname: Chaudhury
authors.affiliation: Department of Chemistry, Jadavpur University, 188, Raja, S. C. Mullick Road, Kolkata-700 032, India. ghoshrina@yahoo.com.
authors.forename: Rina
authors.identifier: http://orcid.org/0000-0001-5040-3105
authors.initials: R
authors.lastname: Ghosh
mesh_terms: D000606:Amino Sugars / Q000138:chemical synthesis* / Q000737:chemistry; D001419:Bacteria / Q000737:chemistry*; D002236:Carbohydrate Conformation
chemical_list: D000606:Amino Sugars