title: Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population.
abstract: OBJECTIVE
  We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes identified in previous studies.
  
  
  METHODS
  A total of 124 patients and 1345 treated controls were genotyped using Illumina arrays. The genome-wide significance level was set to p < 5 × 10-8.
  
  
  RESULTS
  We identified nearly genome-wide significant associations in CLASP1, PDE11A, KCNMB2, TGFA, SLC38A6 and MMP16. The strongest association was with rs62151109 in CLASP1 (odds ratio: 3.97; p = 9.44 × 10-8). All top hits except two were located in intronic or noncoding DNA regions. None of the candidate genes were significantly associated in our study.
  
  
  CONCLUSIONS
  Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways.
authors.affiliation: Department of Medical Sciences, Clinical Pharmacology & Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Pär
authors.initials: P
authors.lastname: Hallberg
authors.affiliation: Department of Medical Sciences, Clinical Pharmacology & Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Matilda
authors.initials: M
authors.lastname: Persson
authors.affiliation: Department of Medical Sciences, Molecular Medicine & Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Tomas
authors.initials: T
authors.lastname: Axelsson
authors.affiliation: Department of Immunology, Genetics & Pathology & Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Marco
authors.initials: M
authors.lastname: Cavalli
authors.affiliation: Sickla Health Centre, Nacka, Sweden.
authors.forename: Pia
authors.initials: P
authors.lastname: Norling
authors.affiliation: Department of Public Health & Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
authors.forename: Hans-Erik
authors.initials: HE
authors.lastname: Johansson
authors.affiliation: Medical Products Agency, Uppsala, Sweden.
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Yue
authors.affiliation: Swedish Twin Registry, Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm.
authors.forename: Patrik Ke
authors.initials: PK
authors.lastname: Magnusson
authors.affiliation: Department of Immunology, Genetics & Pathology & Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Claes
authors.initials: C
authors.lastname: Wadelius
authors.affiliation: Uppsala Clinical Research Center & Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Niclas
authors.initials: N
authors.lastname: Eriksson
authors.affiliation: Department of Medical Sciences, Clinical Pharmacology & Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Mia
authors.initials: M
authors.lastname: Wadelius
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D003371:Cough / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
keywords: angiotensin converting enzyme inhibitors; bradykinin; cough; drug-related side effects and adverse reactions; enalapril; genome-wide association study; lisinopril; pharmacogenetics; quinapril; ramipril