title: Asthma and the risk of lung cancer: a meta-analysis.
abstract: Some studies found that there was a significant association between asthma and the risk of lung cancer. However, the results are inconclusive. Therefore, we performed a meta-analysis. We searched the electronic databases for all relevant articles. Odds ratio (OR) with 95% confidence interval (CI) were used to calculate the strength of the association between asthma and lung cancer risk. Asthma was significantly associated with the increased risk of lung cancer (OR = 1.44; 95% CI 1.31-1.59; P < 0.00001; I2 = 83%). Additionally, asthma patients without smoking also had the increased lung cancer risk. In the subgroup analysis of race and gender, Caucasians, Asians, male, and female patients with asthma showed the increased risk of lung cancer. However, asthma was not significantly associated with lung adenocarcinoma risk. In the stratified analysis by asthma definition, significant associations were found between asthma and lung cancer in self-reported subgroup, questionnaire subgroup, and register databases subgroup. However, no significant association was observed in physician-diagnosed asthma subgroup. In conclusion, this meta-analysis suggested that asthma might be significantly associated with lung cancer risk.
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Yan-Liang
authors.initials: YL
authors.lastname: Qu
authors.affiliation: Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Chun-Min
authors.initials: CM
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Ai-Jie
authors.initials: AJ
authors.lastname: Chu
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Bao-Lei
authors.initials: BL
authors.lastname: Wen
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Xu-Yan
authors.initials: XY
authors.lastname: Yan
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: De-Ming
authors.initials: DM
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lv
authors.affiliation: Department of Hand Surgery, Hospital of PLA, Qingdao 266071, Shandong, China.
authors.forename: Shu-Jian
authors.initials: SJ
authors.lastname: Hou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012306:Risk; D055815:Young Adult
keywords: association; asthma; lung cancer; meta-analysis