title: Association betweenLAPTM4Bgene polymorphism and prostate cancer susceptibility in an Iranian population.
abstract: Lysosome associated protein transmembrane 4 β (LAPTM4B) is an oncogene associated with many human cancers. In the present study we aimed to examine the possible association betweenLAPTM4Bpolymorphism and risk of prostate cancer (PCa) in an Iranian population. This case control study was performed on 168 patients with PCa and 176 controls with benign prostatic hyperplasia (BPH). Genomic DNA was extracted from whole blood andLAPTM4Bgenotypes were identified by polymerase chain reaction. The distributions ofLAPTM4Bgenotypes were significantly different between PCa patients (60.7% for *1/1, 32.8% for *1/2, and 6.5% for *2/2) and controls (44.9% for *1/1, 49.4% for *1/2, and 5.7% for *2/2). Both the *1/2 and *1/2+*2/2 genotypes significantly decreased the risk of PCa compared with the *1/1 genotype (OR = 49, 95% CI = 0.31-0.77, p = 0.002 and OR = 0.53, 95% CI = 0.34-0.81, p = 0.004, respectively). The minor allele (LAPTM4B*2) was associated with a decreased risk of PCa compared with theLAPTM4B*1 allele (OR = 0.68, 95% CI = 0.48-0.96, p = 0.031). Moreover,LAPTM4Bpolymorphism was not associated with clinicopathological characteristics of PCa patients. The results of this study showed thatLAPTM4B*2 was associated with a decreased risk of PCa but the clinicopathological characteristics of PCa were not linked toLAPTM4Bpolymorphism. Further studies with larger sample sizes and different ethnicities are needed to confirm our findings.
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences , Zahedan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Rezaei
authors.affiliation: Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Narouie
authors.affiliation: Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Nasser
authors.initials: N
authors.lastname: Simforoosh
authors.affiliation: Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Basiri
authors.affiliation: Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Sayed Amir Mohsen
authors.initials: SA
authors.lastname: Ziaee
authors.affiliation: Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences , Zahedan, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Bahari
authors.affiliation: Genetic of Non Communicable Disease Research Center, School of Medicine, Zahedan University of Medical Sciences , Zahedan, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taheri
keywords: Genotype; LAPTM4B; gene; polymorphism; prostate cancer