title: Preliminary study of the effects of furosemide on blood pressure during late-onset pre-eclampsia in patients with high cardiac output.
abstract: OBJECTIVE
  To examine the effect of furosemide on hypertension and edema in patients with pre-eclampsia experiencing high cardiac output.
  
  
  METHODS
  The present cohort study enrolled patients with pre-eclampsia who were admitted to the pregnancy pathology unit of the Department of Obstetrics and Gynecology, University of Pécs, Hungary, between January 1 and December 31, 2015. Eligible patients had singleton pregnancies with no fetal anomalies, high blood volume, visible edema, and a hematocrit concentration below 37 L/L. Blood pressure was measured and impedance cardiography was used to determine cardiac output for all patients before they received a 40-mg dose of furosemide; after 60 minutes blood pressure and cardiac output were measured again.
  
  
  RESULTS
  The study enrolled 14 patients. Lower cardiac output (P=0.002), systolic blood pressure (P=0.002), and diastolic blood pressure (P=0.002) were recorded after furosemide administration, with patient heart rates remaining stable.
  
  
  CONCLUSIONS
  The heart-rate stability suggests that the change of cardiac output was due to a decrease in blood volume. These data suggest that diuretics could be useful in the management of late-onset pre-eclampsia, indicating that an increase in water retention could play a role in the development of late-onset pre-eclampsia.
authors.affiliation: Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.|Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Tamás
authors.affiliation: Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.|Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Hantosi
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, Pécs, Hungary.|MTA-PTE Human Reproduction Scientific Research Group, Pécs, Hungary.
authors.forename: Bálint
authors.initials: B
authors.lastname: Farkas
authors.affiliation: Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.|Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Ifi
authors.affiliation: Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Betlehem
authors.affiliation: Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.|Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, Pécs, Hungary.|MTA-PTE Human Reproduction Scientific Research Group, Pécs, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Bódis
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D016534:Cardiac Output, High / Q000188:drug therapy*; D015331:Cohort Studies; D004232:Diuretics / Q000008:administration & dosage*; D005260:Female; D005665:Furosemide / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006814:Hungary; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy
chemical_list: D004232:Diuretics; D005665:Furosemide
keywords: Furosemide; High cardiac output; Late-onset pre-eclampsia; Management