title: Peripheral blood CD4+/CD25+regulatory T cells in alcoholic patients with Strongyloides stercoralis infection.
abstract: An increased number of regulatory T (Treg) cells has been reported in patients with HTLV-1 and Strongyloides stercoralis co-infection, suggesting the contribution of these cells to worm survival. As Strongyloides infections have been found to be highly prevalent in chronic alcoholics, we investigated the effect of abusive ethanol ingestion on the induction of Treg cells in alcoholic patients with Strongyloides infection. Treg cells were assessed by flow cytometry in the peripheral blood of 12 healthy non-alcoholic (control) and 14 alcoholic patients (alcoholic) without Strongyloides infection and five non-alcoholics (controlSs) and five chronic alcoholics (alcoholSs) with Strongyloides infection. The results showed significantly higher frequencies of Treg cells in the alcoholic, controlSs and alcoholSs group patients than in the control group patients. However, the frequencies of Treg cells did not differ between the alcoholSs and controlSs groups. In conclusion, our results demonstrate that ethanol consumption induced an increase in the number of circulating Treg cells in chronic alcoholics in this study but was unable to potentiate the induction of these cells in alcoholics with Strongyloides infection.
authors.affiliation: Núcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, Vitória, ES, CEP: 29043-900, Brazil.
authors.forename: Steveen Rios
authors.initials: SR
authors.lastname: Ribeiro
authors.affiliation: Núcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, Vitória, ES, CEP: 29043-900, Brazil.
authors.forename: Luciana Polaco
authors.initials: LP
authors.lastname: Covre
authors.affiliation: Núcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, Vitória, ES, CEP: 29043-900, Brazil.
authors.forename: Lorenzzo Lyrio
authors.initials: LL
authors.lastname: Stringari
authors.affiliation: Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: da Penha Zago-Gomes
authors.affiliation: Núcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, Vitória, ES, CEP: 29043-900, Brazil.|Núcleo de Biotecnologia, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
authors.forename: Daniel Cláudio Oliveira
authors.initials: DC
authors.lastname: Gomes
authors.affiliation: Núcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, Vitória, ES, CEP: 29043-900, Brazil. felp@ndi.ufes.br.
authors.forename: Fausto Edmundo Lima
authors.initials: FE
authors.lastname: Pereira
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000276:immunology / Q000469:parasitology; D000818:Animals; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D017171:Strongyloides stercoralis / Q000502:physiology*; D013322:Strongyloidiasis / Q000097:blood* / Q000276:immunology / Q000469:parasitology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000276:immunology
keywords: Alcoholism; Strongyloides stercoralis; Treg cells