title: Antithrombotic agents intake prior to injury does not affect outcome after a traumatic brain injury in hospitalized elderly patients.
abstract: BACKGROUND
  The purpose of this study is to investigate the effect of risk factors including International Normalized Ratio (INR) as well as the Partial Thromboplastin Time (PTT) scores on several outcomes, including hospital length of stay (LOS) and The Extended Glasgow Outcome Scale (GOSE) following TBI in the elderly population.
  
  
  METHODS
  Data were retrospectively collected on patients (n=982) aged 65 and above who were admitted post TBI to the McGill University Health Centre-Montreal General Hospital from 2000 to 2011. Age, Injury Severity Score (ISS), Glasgow Coma Scale score (GCS), type of trauma (isolated TBI vs polytrauma including TBI), initial CT scan results according to the Marshall Classification and the INR and PTT scores and prescriptions of antiplatelet or anticoagulant agents (AP/AC) were collected.
  
  
  RESULTS
  Results also indicated that age, ISS and GSC score have an effect on the GOSE score. We also found that taking AC/AP has an effect on GOSE outcome, but that this effects depends on PTT, with lower odds of a worse outcome for those taking AC/AP agents as the PTT value goes up. However, this effect only becomes significant as the PTT value reaches 60 and above.
  
  
  CONCLUSIONS
  Age and injury severity rather than antithrombotic agent intake are associated with adverse acute outcome such as GOSE in hospitalized elderly TBI patients.
authors.affiliation: Department of Psychology, University of Montreal, Canada; Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain (CRIR), Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Julien
authors.affiliation: Montreal Neurological Institute & Hospital, McGill University, Canada.
authors.forename: Ghusn
authors.initials: G
authors.lastname: Alsideiri
authors.affiliation: Neurology and Neurosurgery Department, McGill University Health Centre, Canada.
authors.forename: Judith
authors.initials: J
authors.lastname: Marcoux
authors.affiliation: University of Dammam, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hasen
authors.affiliation: Department of Mathematics and Statistics, McGill University, Canada.
authors.forename: José A
authors.initials: JA
authors.lastname: Correa
authors.affiliation: Traumatic Brain Injury Program, McGill University Health Centre, Canada.
authors.forename: Mitra
authors.initials: M
authors.lastname: Feyz
authors.affiliation: Neurology and Neurosurgery Department, McGill University Health Centre, Canada.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Maleki
authors.affiliation: Department of Psychology, University of Montreal, Canada; Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain (CRIR), Canada; Research Institute-McGill University Health Center, Canada. Electronic address: elaine.de.guise@umontreal.ca.
authors.forename: Elaine
authors.initials: E
authors.lastname: de Guise
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000070642:Brain Injuries, Traumatic / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D023261:Glasgow Outcome Scale / Q000639:trends; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D015601:Injury Severity Score; D007902:Length of Stay / Q000639:trends; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents
keywords: Aging; Level 1 trauma center; Older age; Outcome; Traumatic brain injury