title: Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis.
abstract: Four hitherto unknown polysubstituted isoflavonoids, including three isoflavans: 7,4'-dihydroxy-8,2',3'-trimethoxyisoflavan (1), 7,2',4'-trihydroxy-8,3'-dimethoxyisoflavan (2), and 7,2',4'-trihydroxy-5-methoxyisoflavan (3), and one prenylated isoflavone cudraisoflavone M (4) were isolated from the ethanol extracts of Spatholobus suberectus (for 1 and 2), Flemingia macrophylla (for 3), and Cudrania cochinchinensis (for 4), respectively. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480).
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Wang
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Zheng
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Fu-Cai
authors.initials: FC
authors.lastname: Ren
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Tian-Ge
authors.initials: TG
authors.lastname: Chen
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Xiang-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Jiang
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China. f.wang@mail.biobiopha.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
keywords: Cudrania cochinchinensis; Cytotoxicity; Flemingia macrophylla; Isoflavan; Isoflavone; Spatholobus suberectus