title: Inhibitory Effects of Constituents from the Aerial Parts of Rosmarinus officinalis L. on Triglyceride Accumulation.
abstract: Sixteen flavonoids (1-16) including two new ones, named officinoflavonosides A (1) and B (2) were obtained from the aerial parts ofRosmarinus officinalis. Among the known ones,6,10, and13were isolated from the rosmarinus genus for the first time. Their structures were elucidated by chemical and spectroscopic methods. Moreover, the effects on sodium oleate-induced triglyceride accumulation (TG) in HepG2 cells of the above-mentioned compounds and 16 other isolates (17-32) reported previously to have been obtained in the plant were analyzed. Results show that eight kinds of flavonoids (compounds1,2,3,6-9and11) and seven kinds of other known isolates (compounds17-20,23,26and31) possessed significant inhibitory effects on intracellular TG content in HepG2 cells. Among them, the activities of compounds1and20were comparable to that of orlistat, which suggested that these compounds in this plant might be involved in lipid metabolism.
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. beyondwill@126.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. tiwa_ade@yahoo.com.
authors.forename: Tiwalade Adegoke
authors.initials: TA
authors.lastname: Adelakun
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. 15122587883@163.com.
authors.forename: Sijian
authors.initials: S
authors.lastname: Wang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. Ruanjy19930919@163.com.
authors.forename: Jingya
authors.initials: J
authors.lastname: Ruan
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. 15122473723@163.com.
authors.forename: Shengcai
authors.initials: S
authors.lastname: Yang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. huifeidedouzi@yeah.net.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Li
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. zhwwxzh@263.net.|Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. zhwwxzh@263.net.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. wangtao@tjutcm.edu.cn.|Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. wangtao@tjutcm.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D005419:Flavonoids / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D019301:Oleic Acid / Q000737:chemistry; D064209:Phytochemicals / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D027542:Rosmarinus / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D064209:Phytochemicals; D010936:Plant Extracts; D013729:Terpenes; D014280:Triglycerides; D019301:Oleic Acid
keywords: HepG2 cells; Rosmarinus officinalis; flavonoids; phenolic acids; terpenoids; triglyceride accumulation inhibitory effects