title: Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin.
abstract: Cadherin-based adherens junctions are conserved structures that mediate epithelial cell-cell adhesion in invertebrates and vertebrates. Despite their pivotal function in epithelial integrity, adherens junctions show a remarkable plasticity that is a prerequisite for tissue architecture and morphogenesis. Epithelial cadherin (E-cadherin) is continuously turned over and undergoes cycles of endocytosis, sorting and recycling back to the plasma membrane. Mammalian cell culture and genetically tractable model systems such asDrosophilahave revealed conserved, but also distinct, mechanisms in the regulation of E-cadherin membrane trafficking. Here, we discuss our current knowledge about molecules and mechanisms controlling endocytosis, sorting and recycling of E-cadherin during junctional remodeling.
authors.affiliation: Institut für Neurobiologie, Universität Münster, Badestraße 9, 48149 Münster, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Brüser
authors.affiliation: Institut für Neurobiologie, Universität Münster, Badestraße 9, 48149 Münster, Germany.|Institut für Physiologie und Pathophysiologie, Abteilung Molekulare Zellphysiologie, Phillips-Universität Marburg, Emil-Mannkopff-Straße 2, 35037 Marburg, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Bogdan
mesh_terms: D022005:Adherens Junctions / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D015820:Cadherins / Q000378:metabolism*; D051177:Catenins / Q000502:physiology; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D015820:Cadherins; D051177:Catenins