title: Can individualized sunitinib dose and schedule changes optimize outcomes for kidney cancer patients?
abstract: The recommended starting dose and schedule for sunitinib is 50 mg daily for 28 days, followed by a 14-day break with significant dose reductions to 37.5 mg (75% of starting dose), and then 25 mg (50% of starting dose) on the same schedule (four/two schedule). There are several reasons why these dose and scheduling recommendations may not be optimal for most patients, as outlined below.
authors.affiliation: Division of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada.
authors.forename: Georg A
authors.initials: GA
authors.lastname: Bjarnason