title: New Experimental Model of Rat Risk Behavior. Effects of Nicotine and Phenazepam.
abstract: We described a new model of risk behavior in rats that allows selection of animals predisposed to risk behavior in the absence of other biological motivations. Phenazepam administration did not change the intensity of risk behavior in "risky" animals, but stimulated risk behavior in rats that were not predisposed to it. Nicotine inhibited risk behavior in "risky" animals and strengthened it in "cautious" rats. In the intermediate group, the drugs did not induce significant changes. A similar effect of the drugs was observed in the previous models. More complex effect of nicotine on the risk behavior may be explained by the absence of severe food motivation typical for the early models.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. s-sudakov@nphys.ru.
authors.forename: S K
authors.initials: SK
authors.lastname: Sudakov
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Nazarova
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Alekseeva
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001569:Benzodiazepines / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology / Q000523:psychology; D006815:Hunger / Q000187:drug effects / Q000502:physiology; D008297:Male; D008954:Models, Biological; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012309:Risk-Taking; D012527:Satiation / Q000187:drug effects* / Q000502:physiology
chemical_list: D001569:Benzodiazepines; C017928:phenazepam; D009538:Nicotine
keywords: anxiety; food motivation; nicotine; phenazepam; risk behavior