title: Mitochondria Initiate and Regulate Sarcopenia.
abstract: We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.
authors.affiliation: 1Division of Exercise Physiology; 2Center for Cardiovascular and Respiratory Sciences, and Mitochondria, Metabolism, and Bioenergetics; and 3Centers for Neuroscience, West Virginia University School of Medicine, Morgantown, WV.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Alway
authors.forename: Junaith S
authors.initials: JS
authors.lastname: Mohamed
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Myers
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016923:Cell Death; D000071161:Forkhead Box Protein O1 / Q000378:metabolism; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism*; D063306:Mitophagy; D009046:Motor Neurons / Q000378:metabolism; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism*; D009133:Muscular Atrophy / Q000378:metabolism; D055948:Sarcopenia / Q000378:metabolism*; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D000071161:Forkhead Box Protein O1; D025801:Ubiquitin