title: A paralogous decoy protectsPhytophthora sojaeapoplastic effector PsXEG1 from a host inhibitor.
abstract: The extracellular space (apoplast) of plant tissue represents a critical battleground between plants and attacking microbes. Here we show that a pathogen-secreted apoplastic xyloglucan-specific endoglucanase, PsXEG1, is a focus of this struggle in thePhytophthora sojae-soybean interaction. We show that soybean produces an apoplastic glucanase inhibitor protein, GmGIP1, that binds to PsXEG1 to block its contribution to virulence.P. sojae, however, secretes a paralogous PsXEG1-like protein, PsXLP1, that has lost enzyme activity but binds to GmGIP1 more tightly than does PsXEG1, thus freeing PsXEG1 to supportP. sojaeinfection. The gene pair encoding PsXEG1 and PsXLP1 is conserved in manyPhytophthoraspecies, and theP. parasiticaorthologs PpXEG1 and PpXLP1 have similar functions. Thus, this apoplastic decoy strategy may be widely used inPhytophthorapathosystems.
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Zhenchuan
authors.identifier: 0000-0002-8478-2833
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Lin
authors.identifier: 0000-0003-1460-8415
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Tianqiao
authors.identifier: 0000-0002-4946-6149
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Yang
authors.identifier: 0000-0001-9101-2899
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Qi
authors.identifier: 0000-0003-2463-764X
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Yeqiang
authors.identifier: 0000-0001-9016-7610
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Min
authors.identifier: 0000-0001-9493-3044
authors.initials: M
authors.lastname: Qiu
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Yachun
authors.identifier: 0000-0001-7353-8918
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Haiyang
authors.identifier: 0000-0002-8205-4875
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Kong
authors.affiliation: Center for Genome Research and Biocomputing and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Yufeng
authors.identifier: 0000-0002-5440-2246
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Wenwu
authors.identifier: 0000-0001-7347-8935
authors.initials: W
authors.lastname: Ye
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Yan
authors.identifier: 0000-0001-7465-5518
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Suomeng
authors.initials: S
authors.lastname: Dong
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Center for Genome Research and Biocomputing and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Brett M
authors.identifier: 0000-0003-1549-2987
authors.initials: BM
authors.lastname: Tyler
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China. wangyc@njau.edu.cn.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.
authors.forename: Yuanchao
authors.identifier: 0000-0001-5803-5343
authors.initials: Y
authors.lastname: Wang
mesh_terms: D002480:Cellulase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D005110:Extracellular Space / Q000469:parasitology; D005936:Glucans / Q000378:metabolism; D054884:Host-Pathogen Interactions; D010838:Phytophthora / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D010935:Plant Diseases / Q000469:parasitology*; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D013025:Glycine max / Q000201:enzymology* / Q000235:genetics / Q000469:parasitology*; D014774:Virulence; D014990:Xylans / Q000378:metabolism
chemical_list: D005936:Glucans; D010940:Plant Proteins; D014990:Xylans; C029353:xyloglucan; D002480:Cellulase