title: ASSESSMENT OF THE RETINAL STRUCTURE IN CHILDREN WITH INCONTINENTIA PIGMENTI.
abstract: OBJECTIVE
  This report aims at expanding the current knowledge of retinal microanatomy in children with incontinentia pigmenti using hand-held spectral domain optical coherence tomography (SDOCT).
  
  
  METHODS
  We reviewed OCT scans from 7 children (4 weeks-13 years) obtained either in the clinic or during an examination under anesthesia. The scans were analyzed for anatomical changes in the outer and inner retina, by certified graders. Medical records were assessed for systemic findings.
  
  
  RESULTS
  We observed abnormal retinal findings unilaterally in three children. We found inner and outer retinal thinning temporally in two participants. This thinning was present prior to and persisted after treatment. One child showed a distorted foveal contour and significant retinal thickening secondary to dense epiretinal membrane and vitreomacular traction. All other children had normal retinae.
  
  
  CONCLUSIONS
  Hand-held SDOCT imaging of the retina has brought to light additional retinal structural defects that were not previously reported or visualized via routine clinical ophthalmic examination including retinal photography. Despite a normal foveal structure and visual acuity, we identified inner and outer retinal thinning on SDOCT which may benefit from future functional assessment such as visual field testing.
authors.affiliation: *Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina; and †Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina.
authors.forename: Shwetha
authors.initials: S
authors.lastname: Mangalesh
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Du
authors.initials: D
authors.lastname: Tran-Viet
authors.forename: Christian
authors.initials: C
authors.lastname: Viehland
authors.forename: Sharon F
authors.initials: SF
authors.lastname: Freedman
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Toth
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007184:Incontinentia Pigmenti / Q000000981:diagnostic imaging*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity