title: Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma.
abstract: Objective. To evaluate the HER2 expression on gastric adenocarcinoma from a Brazilian population and also to analyze the relations between the receptor and clinical characteristics, as well as the survival status.Materials and Methods. A retrospective analysis was conducted from January of 2008 to July of 2012, considering only gastrectomies with curative intent. Tumors were tested for HER2 status using immunohistochemistry. The relation between HER2 status and clinical aspects, surgical findings, and survival were also analyzed.Results. 222 patients with gastric carcinoma were submitted to surgery during that period, but only 121 (54,5%) were with curative intention. The immunohistochemistry revealed that 4 patients (3,3%) were HER2-positive, 6 patients (4,9%) HER2-undetermined, and 111 patients (91,7%) HER2-negative. There was no statistical concordance between HER2 status and survival or the clinical aspects.Conclusion. The HER2 overexpression rate was very low in this Brazilian population sample and cannot be considered as a prognostic factor.
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Roberto de Moraes
authors.identifier: 0000-0003-1762-5480
authors.initials: RM
authors.lastname: Cordts Filho
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Paulo
authors.identifier: 0000-0002-5115-6297
authors.initials: P
authors.lastname: Kassab
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Laura Carolina Lopez
authors.initials: LC
authors.lastname: Claro
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Mabel Tatty de Medeiros
authors.identifier: 0000-0002-1935-2917
authors.initials: MT
authors.lastname: Fracassi
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Patrícia
authors.identifier: 0000-0003-0247-4245
authors.initials: P
authors.lastname: Colombo-Souza
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Daniel Kenji
authors.initials: DK
authors.lastname: Fukuhara
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Fábio Rodrigues
authors.initials: FR
authors.lastname: Thuler
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Wilson Rodrigues
authors.identifier: 0000-0002-8394-3842
authors.initials: WR
authors.lastname: de Freitas Junior
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Elias Jirjoss
authors.initials: EJ
authors.lastname: Ilias
authors.affiliation: Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Carlos Alberto
authors.identifier: 0000-0002-5730-7973
authors.initials: CA
authors.lastname: Malheiros
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human