title: PdII/AgI-Catalyzed Room-Temperature Reaction of γ-Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity.
abstract: The present work reports a PdII/AgI-promoted amidoalkylation reaction involving various γ-hydroxy lactams and C/O/S nucleophiles at room temperature. The dual mode of activation of both the electrophile and nucleophile by in situ generated catalytically active cationic PdIIspecies facilitates the reaction at room temperature. Among the synthesized isoindoline derivatives, three compounds are found to be active against vancomycin and methicillin-resistant S. aureus strain with appreciable MIC values.
authors.affiliation: Department of Chemical Sciences, Tezpur University , Napaam, Tezpur, Assam 784028, India.
authors.forename: Manali
authors.initials: M
authors.lastname: Dutta
authors.affiliation: Central Research Facility, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
authors.forename: Santi M
authors.initials: SM
authors.lastname: Mandal
authors.affiliation: Department of Chemical Sciences, Tezpur University , Napaam, Tezpur, Assam 784028, India.
authors.forename: Rupa
authors.initials: R
authors.lastname: Pegu
authors.affiliation: Department of Chemical Sciences, Tezpur University , Napaam, Tezpur, Assam 784028, India.
authors.forename: Sanjay
authors.identifier: 0000-0002-0229-735X
authors.initials: S
authors.lastname: Pratihar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D004305:Dose-Response Relationship, Drug; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013696:Temperature; D020713:Vancomycin Resistance / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D012834:Silver; D010165:Palladium