title: The evaluation of a new marker of transmyocardial repolarization parameters in ischemic stroke patients; Tpeak-Tend(Tp-e), Tp-e/QTc.
abstract: The cardiovascular manifestations of acute ischemic stroke have been well known. Several electrocardiography (ECG) abnormalities have been reported in patients following acute stroke, including QT interval prolongation, ST segment deviation and T-wave changes. This study aimed to investigate the changes in transmyocardial repolarization parameters, in ischemic stroke patients. The study is a prospective, blind, and controlled clinical study. The patients without cardiac disease who received ischemic stroke diagnoses were included in the study. ECG was received from the patients in the first hour and 72 h. The P, QT, Tp-e, Tp-edispersion, and the Tp-e/QT ratio were calculated. Moreover, fifty-five stroke patients and 35 control subjects were included to the study. All dispersion values and Tp-e/QTcratio in patients group were higher than those of control group (p < 0.05 for all values). When evaluated between ECGs' on first and third days, it was found that decreasing on all dispersion values and Tp-e/QTcratio in ECGs on third day than ECGs on first day (p < 0.05 for all values). QT, QTc, and Tp-edispersions values in patients who have insular lobe involvement were higher than those of patients who do not have insular lobe involvement (p < 0.001 for all values). In this study, we showed that acute stroke increases that Pd, QTd, QTcdand new repolarization markers Tp-eand Tp-e/QTc, during first 24 and 72 h in acute stroke patients without cardiovascular disease compared with the control group. The physicians should be aware about ventricular dysrhythmias in patients with ischemic stroke and these patients closely observed with cardiac monitoring, especially within first 24 h, and especially patients with insular lobe involvement.
authors.affiliation: Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey. emineakinci@yahoo.com.
authors.forename: Emine
authors.initials: E
authors.lastname: Emektar
authors.affiliation: Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey.
authors.forename: Şeref Kerem
authors.initials: ŞK
authors.lastname: Çorbacıoğlu
authors.affiliation: Department of Neurology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Korucu
authors.affiliation: Department of Radiology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Ramadan
authors.affiliation: Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Uzunosmanoğlu
authors.affiliation: Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Kan
authors.affiliation: Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey.
authors.forename: Yunsur
authors.initials: Y
authors.lastname: Çevik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods / Q000592:standards*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D020521:Stroke / Q000000981:diagnostic imaging* / Q000503:physiopathology*
keywords: P; QT; Stroke; T p-e; T p-e dispersion; T p-e/QT ratio