title: AChiralPentagonalPolyhedralFramework forCharacterizingVirusCapsidStructures.
abstract: Recent developments of rational strategies for the design of antiviral therapies, including monoclonal antibodies (mAbs), have naturally relied extensively on available viral structural information. As new strategies continue to be developed, it is equally important to continue to refine our understanding and interpretation of viral structural data. There are known limitations to the traditional (Caspar-Klug) theory for describing virus capsid structures that involves subdividing a capsid into triangular subunits. In this context, we describe a more general polyhedral framework for describing virus capsid structures that is able to account for many of these limitations, including a more thorough characterization of intersubunit interfaces. Additionally, our use of pentagonal subunits instead of triangular ones accounts for the intrinsic chirality observed in all capsids. In conjunction with the existing theory, the framework presented here provides a more complete picture of a capsid's structure and therefore can help contribute to the development of more effective antiviral strategies.
authors.affiliation: Harvard College, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Aditya
authors.initials: A
authors.lastname: Raguram
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: V
authors.initials: V
authors.lastname: Sasisekharan
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: rams@mit.edu.
authors.forename: Ram
authors.initials: R
authors.lastname: Sasisekharan
mesh_terms: D002213:Capsid / Q000737:chemistry* / Q000648:ultrastructure; D036022:Capsid Proteins / Q000737:chemistry; D008954:Models, Biological; D011487:Protein Conformation; D015678:Viral Structural Proteins / Q000737:chemistry* / Q000648:ultrastructure; D019065:Virus Assembly
chemical_list: D036022:Capsid Proteins; D015678:Viral Structural Proteins
keywords: pentagon; polyhedral; structure; virus