title: Bisphenol A Metabolites and Bisphenol S in Paired Maternal and Cord Serum.
abstract: Human studies show associations between maternal bisphenol A (BPA) exposure and developmental effects in children, yet biomonitoring of BPA metabolites in maternal and fetal serum remains limited, and less is known for BPA alternatives. BPA-glucuronide, BPA-sulfate, and bisphenol S (BPS) were quantified in 61 pairs of maternal and cord sera from Chinese participants. Total BPS was only detectable in four maternal (<0.03-0.07 ng/mL) and seven cord sera (<0.03-0.12 ng/mL), indicating low exposure but providing the first evidence that BPS crosses the human placenta. Total BPA metabolites in cord serum were significantly higher than in maternal serum (p < 0.05), suggesting that these may be formed in the fetus or cleared more slowly from the fetoplacental compartment. Unlike the pharmacokinetic results from controlled oral exposure studies in which BPA-glucuronide is the major BPA metabolite, here, BPA-sulfate was the dominant metabolite (GM: 0.06 and 0.08 ng/mL), significantly higher than BPA-glucuronide (GM: 0.02 and 0.04 ng/mL) (p < 0.01) in both maternal and cord sera. Moreover, the proportion of BPA-sulfate increased with total BPA. These are the first human data for BPA metabolites in paired maternal and cord serum, and results suggest that the human fetus and pregnant mother have unique exposure to BPA metabolites. Direct analysis of BPA metabolites in serum provides complementary information for evaluating early life-stage exposure and risks of BPA.
authors.affiliation: Chaoyang District Center for Disease Control and Prevention , Beijing 100021, China.
authors.forename: Jiaying
authors.identifier: 0000-0002-1274-3800
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Lab of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment , Beijing 100022, China.
authors.forename: Jingguang
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Lab of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment , Beijing 100022, China.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Lab of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment , Beijing 100022, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Chaoyang District Center for Disease Control and Prevention , Beijing 100021, China.
authors.forename: Fengji
authors.initials: F
authors.lastname: Luo
authors.affiliation: Chaoyang District Center for Disease Control and Prevention , Beijing 100021, China.
authors.forename: Shuming
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Lab of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment , Beijing 100022, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Elham K
authors.initials: EK
authors.lastname: Moez
authors.forename: Irina
authors.initials: I
authors.lastname: Dinu
authors.forename: Jonathan W
authors.identifier: 0000-0001-6265-4294
authors.initials: JW
authors.lastname: Martin
mesh_terms: D001559:Benzhydryl Compounds / Q000378:metabolism*; D004784:Environmental Monitoring; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D018811:Maternal Exposure; D010636:Phenols / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D013431:Sulfates / Q000378:metabolism
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; D013431:Sulfates