title: Current issues in postmortem imaging of perinatal and forensic childhood deaths.
abstract: Perinatal autopsy practice is undergoing a state of change with the introduction of evidence-based cross-sectional imaging, driven primarily by parental choice. In particular, the introduction of post mortem magnetic resonance imaging (PMMR) has helped to advance less-invasive perinatal autopsy in the United Kingdom (UK) and Europe. However, there are limitations to PMMR and other imaging techniques which need to be overcome, particularly with regard to imaging very small fetuses. Imaging is also now increasingly used to investigate particular deaths in childhood, such as suspected non-accidental injury (NAI) and sudden unexpected death in infancy (SUDI). Here we focus on current topical developments the field, with particular emphasis on the application of imaging to perinatal autopsy, and pediatric forensic deaths. Different imaging modalities and their relative advantages and disadvantages are discussed, together with other benefits of more advanced cross-sectional imaging which currently lie in the research domain. Whilst variations in local imaging service provision and need may determine different practice patterns, and access to machines and professionals with appropriate expertise and experience to correctly interpret the findings may limit current practices, we propose that gold standard perinatal and pediatric autopsy services would include complete PMMR imaging prior to autopsy, with PMCT in suspicious childhood deaths. This approach would provide maximal diagnostic yield to the pathologist, forensic investigator and most importantly, the parents.
authors.affiliation: Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK. owen.arthurs@gosh.nhs.uk.|Institute of Child Health, UCL, London, UK. owen.arthurs@gosh.nhs.uk.
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Arthurs
authors.affiliation: Institute of Child Health, UCL, London, UK.|Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
authors.forename: John C
authors.initials: JC
authors.lastname: Hutchinson
authors.affiliation: Institute of Child Health, UCL, London, UK.|Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Sebire
mesh_terms: D002648:Child; D000013:Congenital Abnormalities / Q000175:diagnosis; D005260:Female; D005313:Fetal Death; D005333:Fetus / Q000473:pathology; D049429:Forensic Pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D050497:Stillbirth; D013398:Sudden Infant Death / Q000473:pathology; D014057:Tomography, X-Ray Computed
keywords: Autopsy; Forensic; Imaging; MRI; Pediatric; Perinatal