title: Emerging links between m6A and misregulated mRNA methylation in cancer.
abstract: N6-methyladenosine (m6A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeutic avenue for investigation.
authors.affiliation: Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA. srj2003@med.cornell.edu.
authors.forename: Samie R
authors.initials: SR
authors.lastname: Jaffrey
authors.affiliation: Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. kharasm@mskcc.org.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Kharas
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D006801:Humans; D008745:Methylation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; C010223:N-methyladenosine; D000241:Adenosine