title: [Application of lymph node labeling with carbon nanoparticles by preoperative endoscopic subserosal injection in laparoscopic radical gastrectomy].
abstract: Objective:To evaluate the application value of carbon lymph node tracing technique by preoperative endoscopic subserosal injection in laparoscopic radical gastrectomy.Methods:From June 2013 to February 2015, seventy eight patients with gastric cancer were enrolled and randomly divided into trial group and control group. Subserosal injection of carbon nanoparticles around the tumor was performed by preoperative endoscopic subserosal injection one day before the operation in trial group, while the patients routinely underwent laparoscopic gastrectomy in control group. Results of harvested lymph nodes, postoperative complications were compared between the two groups. Carbon nanoparticle-related side effect was also evaluated.Results:The average number of harvested lymph node in trial group was significantly higher than that in control group (35.5±8.5 vs 29.5±6.5,P<0.05). The rate of overall black-dyed harvested lymph node was 74.7% (1 035/1 386) in trial group, the black-dyed lymph node rate in D1 lymph node was 80.1%, which was significantly higher than that in D2 lymph node (69.8%, χ2=19.38,P<0.01). When comparing the lymph node with and without black-dyed in trial group, the rate of metastasis lymph node was significantly higher in lymph node with black-dyed (17.3% vs 4.0%, χ2=38.67,P<0.01). There was no significant difference in postoperative complications rate between two group (trial group 10.2%; control group 12.8%, χ2=0.00,P>0.05), and no carbon nanoparticle-related side effect was observed.Conclusion:Given a higher harvested lymph node number and a similar rate of complications, preoperative endoscopic subserosal injection of carbon nanoparticles was safe and feasible.
authors.affiliation: Department of Digestive Surgery, Jinhua Guangfu Hospital, Zhejiang 321000, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Hong
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: C G
authors.initials: CG
authors.lastname: Hu
authors.forename: Y J
authors.initials: YJ
authors.lastname: Fang
authors.forename: X X
authors.initials: XX
authors.lastname: Fan
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.forename: Q
authors.initials: Q
authors.lastname: Tong
mesh_terms: D002244:Carbon; D004396:Coloring Agents; D005743:Gastrectomy; D006801:Humans; D007267:Injections; D010535:Laparoscopy; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D053758:Nanoparticles; D013274:Stomach Neoplasms
chemical_list: D004396:Coloring Agents; D002244:Carbon