title: Glycosylation of voltage-gated calcium channels in health and disease.
abstract: Voltage-gated calcium channels (VGCCs) are transmembrane proteins that translate electrical activities into intracellular calcium elevations and downstream signaling pathways. They serve essential physiological functions including communication between nerve cells, muscle contraction, cardiac activity, and release of hormones and neurotransmitters. Asparagine-linked glycosylation has emerged as an essential post-translational modification to control the number of channels embedded in the plasma membrane but also their functional gating properties. This review provides a comprehensive overview about the current state of knowledge on the role of glycosylation in the expression and functioning of VGCCs, and discusses how variations in the glycosylation of the channel proteins can contribute to pathological conditions.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
authors.forename: Joanna
authors.initials: J
authors.lastname: Lazniewska
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic. Electronic address: weiss@uochb.cas.cz.
authors.forename: Norbert
authors.initials: N
authors.lastname: Weiss
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D021122:Protein Subunits
chemical_list: D015220:Calcium Channels; D021122:Protein Subunits
keywords: Ancillary subunit; Calcium channels; Diabetes; N-glycosylation; Neuropathic pain; Plasma membrane; Stability; Trafficking; Voltage-gated calcium channels