title: Immunoglobulin G4 (IgG4)-Related Hypophysitis.
abstract: We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating that the morphologic features of the hypophysial lesion do not depend on the presence of other lesions. The pathogenesis of IgG4 hypophysitis is not known, and further study is necessary to explore the cause, progression, and influencing factors of this disease.
authors.affiliation: Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B1W8, Canada. rotondof@smh.ca.|Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. rotondof@smh.ca.
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.affiliation: Department of Surgery, Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.|Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Amro
authors.initials: A
authors.lastname: Qaddoura
authors.affiliation: Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia.
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
authors.affiliation: Department of Pathology, Montreal Neurological Hospital, McGill University, Montreal, QC, Canada.
authors.forename: Jason
authors.initials: J
authors.lastname: Karamchandani
authors.affiliation: Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B1W8, Canada.|Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: David G
authors.initials: DG
authors.lastname: Munoz
authors.affiliation: Department of Pathology, Laboratorio de Patologia y Citología Rodrigo Restrepo, Clinica Medellin, Medellin, Colombia.
authors.forename: Mariam J
authors.initials: MJ
authors.lastname: Arroyave
authors.affiliation: Department of Internal Medicine, Infectious diseases, Clinica Medellin, Medellin, Colombia.
authors.forename: William P
authors.initials: WP
authors.lastname: Ospina
authors.affiliation: Department of Surgery, Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.|Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
authors.affiliation: Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B1W8, Canada.|Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D000328:Adult; D000069281:Autoimmune Hypophysitis / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Hypophysitis; IgG4 hypophysitis; Neurosurgery; Pathology; Tuberculosis