title: Sequential organogenesis sets two parallel sensory lines in medaka.
abstract: Animal organs are typically formed during embryogenesis by following one specific developmental programme. Here, we report that neuromast organs are generated by two distinct and sequential programmes that result in parallel sensory lines in medaka embryos. A ventral posterior lateral line (pLL) is composed of neuromasts deposited by collectively migrating cells whereas a midline pLL is formed by individually migrating cells. Despite the variable number of neuromasts among embryos, the sequential programmes that we describe here fix an invariable ratio between ventral and midline neuromasts. Mechanistically, we show that the formation of both types of neuromasts depends on the chemokine receptor genescxcr4bandcxcr7b, illustrating how common molecules can mediate different morphogenetic processes. Altogether, we reveal a self-organising feature of the lateral line system that ensures a proper distribution of sensory organs along the body axis.
authors.affiliation: Animal Physiology and Development, Centre for Organismal Studies (COS) Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany.|The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Seleit
authors.affiliation: Animal Physiology and Development, Centre for Organismal Studies (COS) Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany.|The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany.
authors.forename: Isabel
authors.initials: I
authors.lastname: Krämer
authors.affiliation: Animal Physiology and Development, Centre for Organismal Studies (COS) Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ambrosio
authors.affiliation: Animal Physiology and Development, Centre for Organismal Studies (COS) Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany.|Nikon Imaging Center at the University of Heidelberg, Heidelberg, Germany.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dross
authors.affiliation: Animal Physiology and Development, Centre for Organismal Studies (COS) Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany.|Nikon Imaging Center at the University of Heidelberg, Heidelberg, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Engel
authors.affiliation: Animal Physiology and Development, Centre for Organismal Studies (COS) Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany lazaro.centanin@cos.uni-heidelberg.de.
authors.forename: Lázaro
authors.identifier: 0000-0003-3889-4524
authors.initials: L
authors.lastname: Centanin
mesh_terms: D000818:Animals; D019521:Body Patterning; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000378:metabolism; D017403:In Situ Hybridization; D053403:Lateral Line System; D008465:Mechanoreceptors / Q000378:metabolism; D009154:Mutation; D038081:Organogenesis; D009990:Oryzias / Q000196:embryology* / Q000502:physiology*; D054387:Receptors, CXCR / Q000378:metabolism
chemical_list: D018925:Chemokines; D054387:Receptors, CXCR; D049452:Green Fluorescent Proteins
keywords: Cxcr4b; Cxcr7; Eya1; Lateral line; Neuromast; Organogenesis