title: Similar Anemic Control Between Chronic Kidney Diseases in Patients With and Without Transplantation on Entry to Dialysis.
abstract: BACKGROUND
  Transplant recipients are supposedly in a more anemic, catabolic, and even inflammatory state at re-entering hemodialysis due to chronic rejection. The goal of this study was to clarify how transplant recipients can re-enter dialysis safely by focusing on control of anemia.
  
  
  METHODS
  From 2012 to 2014, a total of 29 transplant recipients re-entered hemodialysis because of chronic rejection (ie, the chronic kidney disease with transplant [CKDT] group). At the same time, in 2014, a total of 30 patients with chronic kidney disease without transplantation entered dialysis as the control group (ie, the CKD group). CKDT recipients (mean ± standard deviation age, 41.9 ± 11.8 years; 18 male subjects, 10 female subjects; frequency of diabetes, 10%; duration of graft survival, 12.5 ± 4.3 years) were younger and fewer had diabetes compared with the CKD group (age, 53.2 ± 10.5 years; 21 male subjects, 9 female subjects; frequency of diabetes, 36%). Patient characteristics at entering dialysis in both groups were analyzed according to retrospective chart review.
  
  
  RESULTS
  At entering dialysis, there were no significant differences between the CKD and CKDT groups in terms of the following: dose of darbepoetin; concentrations of hemoglobin, albumin, and C-reactive protein; cardiothoracic ratio; blood urea nitrogen and creatinine levels; estimated glomerular filtration rate; initial ultrafiltration; and duration of hospitalization for initiation of dialysis. The only difference between groups was mean weight at entry to dialysis (CKDT group, 58.5 ± 15.1 kg; CKD group, 67.1 ± 14.8 kg; P = .03). The darbepoetin dose per kilogram of weight did not differ between groups (CKDT, 2.28 ± 2.03 μg/kg; CKD, 2.12 ± 1.6 μg/kg; P = .95) in the final month before entry to dialysis.
  
  
  CONCLUSIONS
  Safe re-initiation of dialysis is important for recipient survival. Although anemia is supposedly higher in transplant recipients due to immunosuppression, this single-center analysis found no difference in anemia in CKD with or without transplantation, caused by good use of erythropoietin-stimulating agents in both groups.
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan. Electronic address: kensakai@med.toho-u.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nihei
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Itabashi
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Muramatsu
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shishido
authors.affiliation: Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Aikawa
mesh_terms: D000328:Adult; D000740:Anemia / Q000150:complications* / Q000188:drug therapy; D000068256:Darbepoetin alfa / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection; D006397:Hematinics / Q000627:therapeutic use; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D006397:Hematinics; D000068256:Darbepoetin alfa