title: Prevalence, risk factors, and clinical outcomes of atopic and nonatopic asthma among rural children.
abstract: Because of time and cost constraints, objective classification of atopic and nonatopic asthma has been limited in large epidemiologic studies. However, as we try to better understand exposure-outcome associations and ensure appropriate treatment of asthma, it is important to focus on phenotype-defined asthma classification.
  
  
  
  To compare atopic and nonatopic asthma in rural children with regard to risk factors and clinical outcomes.
  
  
  
  We conducted a cross-sectional study in rural Saskatchewan, Canada, in 2011. Parents of 6- to 14-year-old children completed a health and exposure survey. Skin prick tests were completed in a subsample of 529 children. Asthma was based physician diagnosis. Asthma status was defined as no asthma, nonatopic asthma, and atopic asthma.
  
  
  
  Asthma prevalence was 14.7% of which 32.1% of cases were atopic. After adjustment, early respiratory illness and a family history of asthma were predictors of childhood asthma, regardless of atopic status (P < .05). Being overweight and having a dog in the home were associated with an increased risk of nonatopic asthma (P < .05). A mother with a history of smoking increased the risk of atopic asthma (P = .01). Compared with those with nonatopic asthma, in the past 12 months, children with atopic asthma were more likely to report a sneezy, runny, or blocked nose or have shortness of breath (odds ratio >2), whereas those with nonatopic asthma were more likely to have parents who missed work (odd ratio >3). Those with nonatopic asthma had significantly lower forced expiratory volume in 1 second compared w2ith those with atopic asthma.
  
  
  
  Exposures may contribute differentially to atopic and nonatopic asthma and result in differential clinical presentation or burden. The study of these characteristics is important for etiologic understanding and management decisions.
authors.affiliation: Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address: josh.lawson@usask.ca.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Lawson
authors.affiliation: Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Health Sciences Program, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Luan M
authors.initials: LM
authors.lastname: Chu
authors.affiliation: Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; College of Nursing, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Donna C
authors.initials: DC
authors.lastname: Rennie
authors.affiliation: Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Louise
authors.initials: L
authors.lastname: Hagel
authors.affiliation: Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Chandima P
authors.initials: CP
authors.lastname: Karunanayake
authors.affiliation: Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Community Health and Epidemiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Punam
authors.initials: P
authors.lastname: Pahwa
authors.affiliation: Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: James A
authors.initials: JA
authors.lastname: Dosman
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D002648:Child; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D016017:Odds Ratio; D063868:Patient Outcome Assessment; D015995:Prevalence; D012129:Respiratory Function Tests; D012307:Risk Factors; D012424:Rural Population; D012525:Saskatchewan / Q000453:epidemiology; D012882:Skin Tests; D011795:Surveys and Questionnaires