title: Different Volumetric Measurement Methods for Pituitary Adenomas and Their Crucial Clinical Significance.
abstract: Confirming the status of residual tumors is crucial. In stationary or spontaneous regression cases, early treatments are inappropriate. The long-used geometric calculation formula is 1/2 (length × width × height). However, it yields only rough estimates and is particularly unreliable for irregularly shaped masses. In our study, we attempted to propose a more accurate method. Between 2004 and 2014, 94 patients with pituitary tumors were enrolled in this retrospective study. All patients underwent transsphenoidal surgery and received magnetic resonance imaging (MRI). The pre- and postoperative volumes calculated using the traditional formula were termed A1 and A2, and those calculated using the proposed method were termed O1 and O2, respectively. Wilcoxon signed rank test revealed no significant difference between the A1 and O1 groups (P = 0.1810) but a significant difference between the A2 and O2 groups (P < 0.0001). Significant differences were present in the extent of resection (P < 0.0001), high-grade cavernous sinus invasion (P = 0.0312), and irregular shape (P = 0.0116). Volume is crucial in evaluating tumor status and determining treatment. Therefore, a more scientific method is especially useful when lesions are irregularly shaped or when treatment is determined exclusively based on the tumor volume.
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Chuang
authors.affiliation: Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Shinn-Yn
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Ping-Ching
authors.initials: PC
authors.lastname: Pai
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Jiun-Lin
authors.initials: JL
authors.lastname: Yan
authors.affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Cheng-Hong
authors.initials: CH
authors.lastname: Toh
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Shih-Tseng
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Zhuo-Hao
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: Institute of Biomedical Engineering National Taiwan University, Taipei, Taiwan, R.O.C.
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Wang
authors.affiliation: Institute of Biomedical Engineering National Taiwan University, Taipei, Taiwan, R.O.C.|Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, R.O.C.|Chang Gung University, Taoyuan, Taiwan, R.O.C.
authors.forename: Cheng-Chi
authors.initials: CC
authors.lastname: Lee
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000601:surgery; D016896:Treatment Outcome; D047368:Tumor Burden