title: A novel and effective delivery method for polyglycolic acid sheets to post-endoscopic submucosal dissection ulcers.
abstract: Background and aimsShielding methods for post-endoscopic submucosal dissection (ESD) ulcers have delivery-related problems. We developed an enveloped device for this purpose and evaluated its usefulness.Materials and methodsPolyglycolic acid (PGA) sheets were delivered to six 3.0-cm ulcers in two resected porcine stomachs and six 5.0-cm ulcers in another three stomachs. In the regular method group, small PGA sheets were delivered via forceps. In the novel method group, a large PGA sheet was delivered via the new device. The methods were compared in terms of time, and macroscopic and histological findings of the ulcer floor.ResultsThe median time required to cover a 3.0-cm ulcer was 0.39 min/cm2in the novel method group and 1.03 min/cm2in the regular method group (P= 0.03), and to cover a 5.0-cm ulcer was 0.38 min/cm2and 0.85 min/cm2, respectively (P= 0.03). In the novel method group, the PGA sheets were in close contact, fully covering the ulcer floor. In the regular method group, the sheets were partly elevated from the ulcer floor.ConclusionsThis novel technique seems promising in this preliminary study.
authors.affiliation: Division of Gastroenterology, Kobe University, Kobe, Hyogo, Japan.
authors.forename: Toshitatsu
authors.initials: T
authors.lastname: Takao
authors.affiliation: The Chemo-Sero-Therapeutic Research Institute, Kumamoto-shi, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Takegawa
authors.affiliation: Endoscopy Division, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ono
authors.affiliation: Division of Gastroenterology, Kobe University, Kobe, Hyogo, Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Takao
authors.affiliation: The Chemo-Sero-Therapeutic Research Institute, Kumamoto-shi, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Oka
authors.affiliation: The Chemo-Sero-Therapeutic Research Institute, Kumamoto-shi, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Shinya
authors.affiliation: Center for Clinical Research and Advanced Medicine Establishment Shiga University of Medical Science, Otsu, Shiga, Japan.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Kutsumi
authors.affiliation: Division of Gastroenterology, Kobe University, Kobe, Hyogo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Azuma
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D000069916:Endoscopic Mucosal Resection / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000601:surgery; D005773:Gastroscopy; D061646:Operative Time; D011100:Polyglycolic Acid; D019919:Prosthesis Implantation / Q000295:instrumentation / Q000379:methods*; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D011100:Polyglycolic Acid