title: Antimicrobial combination treatment including ciprofloxacin decreased the mortality rate of Pseudomonas aeruginosa bacteraemia: a retrospective cohort study.
abstract: Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use of antimicrobial combination therapy composed of a beta-lactam with either ciprofloxacin or tobramycin. To determine if combination therapy correlates to lower mortality and is superior compared to monotherapy, we investigated the effect of antimicrobial treatment regimens on 30-day mortality in a cohort with Pseudomonas aeruginosa bacteraemia. All cases of P. aeruginosa bacteraemia (n = 292) in southwest Skåne County, Sweden (years 2005-2010, adult population 361,112) and the whole county (2011-2012, 966,130) were identified. Available medical and microbiological records for persons aged 18 years or more were reviewed (n = 235). Antimicrobial therapy was defined as empiric at admission or definitive after culture results and was correlated to 30-day mortality in a multivariate regression model. The incidence and mortality rates were 8.0 per 100,000 adults and 22.9% (67/292), respectively. As expected, multiple comorbidities and high age were associated with mortality. Adequate empiric or definitive antipseudomonal treatment was associated with lower mortality than other antimicrobial alternatives (empiric p = 0.02, adj. p = 0.03; definitive p < 0.001, adj. p = 0.007). No difference in mortality was seen between empiric antipseudomonal monotherapy or empiric combination therapy. However, definitive combination therapy including ciprofloxacin correlated to lower mortality than monotherapy (p = 0.006, adj. p = 0.003), whereas combinations including tobramycin did not. Our results underline the importance of adequate antipseudomonal treatment. These data also suggest that P. aeruginosa bacteraemia should be treated with an antimicrobial combination including ciprofloxacin when susceptible.
authors.affiliation: Clinical Microbiology, Department of Translational Medicine, Lund University, Jan Waldenströms gata 59, 205 02, Malmö, Sweden. magnus.paulsson@med.lu.se.
authors.forename: M
authors.identifier: http://orcid.org/0000-0003-1104-2727
authors.initials: M
authors.lastname: Paulsson
authors.affiliation: Infectious Diseases Research Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Granrot
authors.affiliation: Infectious Diseases Research Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Ahl
authors.affiliation: Infectious Diseases Research Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Tham
authors.affiliation: Clinical Microbiology, Department of Translational Medicine, Lund University, Jan Waldenströms gata 59, 205 02, Malmö, Sweden.|Infectious Diseases Research Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Resman
authors.affiliation: Clinical Microbiology, Department of Translational Medicine, Lund University, Jan Waldenströms gata 59, 205 02, Malmö, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Riesbeck
authors.affiliation: Infectious Diseases Research Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Månsson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification*; D012189:Retrospective Studies; D013548:Sweden; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin