title: Proteomic Study of Blood Serum in Coronary Atherosclerosis.
abstract: Changes in the blood serum proteins were assessed in men with coronary atherosclerosis and without coronary heart disease. Proteins were separated by 2D-electrophoresis, protein fractions were identified by their peptide fingerprint by MALDI method; fractions with more than twofold increase in protein level were determined. In blood serum of patients with coronary atherosclerosis, the content of C4 complement protein increased and ceruloplasmin level decreased, which is typical of heart failure and coronary heart disease.
authors.affiliation: Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. stakhneva@yandex.ru.
authors.forename: E M
authors.initials: EM
authors.lastname: Stakhneva
authors.affiliation: Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Meshcheryakova
authors.affiliation: Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Demidov
authors.affiliation: Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Starostin
authors.affiliation: Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Ragino
authors.affiliation: Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: S E
authors.initials: SE
authors.lastname: Peltek
authors.affiliation: Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000378:metabolism*; D003181:Complement C4 / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D008297:Male; D008875:Middle Aged; D040901:Proteomics / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D003181:Complement C4; D002570:Ceruloplasmin
keywords: 2D-electrophoresis; ceruloplasmin; complement system; coronary atherosclerosis; mass spectrometry