title: GnIH Control of Feeding and Reproductive Behaviors.
abstract: In 2000, Tsutsui and colleagues discovered a neuropeptide gonadotropin-inhibitory hormone (GnIH) that inhibits gonadotropin release in birds. Subsequently, extensive studies during the last 15 years have demonstrated that GnIH is a key neurohormone that regulates reproduction in vertebrates, acting in the brain and on the pituitary to modulate reproduction and reproductive behavior. On the other hand, deprivation of food and other metabolic challenges inhibit the reproductive axis as well as sexual motivation. Interestingly, recent studies have further indicated that GnIH controls feeding behavior in vertebrates, such as in birds and mammals. This review summarizes the discovery of GnIH and its conservation in vertebrates and the neuroendocrine control of feeding behavior and reproductive behavior by GnIH.
authors.affiliation: Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University , Tokyo , Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Tsutsui
authors.affiliation: Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Tokyo, Japan; Jeffrey Cheah School of Medicine and Health Sciences, Brain Research Institute Monash Sunway, Monash University Malaysia, Bandar Sunway, Malaysia.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ubuka
keywords: feeding behavior; gonadotropin-inhibitory hormone; gonadotropin-releasing hormone; gonadotropins; reproduction; reproductive behavior