title: Intervention for Cardiac Repair: A Clinical Perspective.
abstract: Cardiovascular disease remains the leading cause of death worldwide. Damage to the heart resulting from cardiovascular disease leads to gradual loss of function and reduced quality of life. Cardiac injury is particularly debilitating, more so than injury to any other organ, given our current inability to either generate new and functional cardiac tissue or to mimic the actions of the heart using external devices. Advances in the field of stem cells and genetics have paved the way for the development of a variety of novel therapies. A number of these therapies have shown great promise in regenerating cardiac tissue in non-human disease models and some have progressed towards clinical trials. Given the rapid progress and emergence of novel targets for therapy, it is perhaps timely that we assess the practicality of these techniques and their potential for translation to bedside. Hence, this review aims to outline the major therapies in development and to provide insight into the feasibility of the respective techniques with the hope that research can be steered towards developing therapies with greater potential of being employed at the bedside.
authors.forename: Esther Hui Na
authors.initials: EHN
authors.lastname: Tan
authors.forename: Zhe Yuan
authors.initials: ZY
authors.lastname: Tay
authors.affiliation: Institute of Molecular and Cell Biology - Stem Cell, Regenerative Medicine And Ageing Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
authors.forename: Boon Seng
authors.initials: BS
authors.lastname: Soh
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000628:therapy*; D006321:Heart / Q000502:physiology*; D006801:Humans; D009206:Myocardium / Q000166:cytology; D032383:Myocytes, Cardiac / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods*
keywords: Ischemic heart disease; cellular based intervention; molecular intervention; reprogramming; scaffold; tissue engineering