title: Association of Osteopontin Gene Polymorphisms with Colorectal Cancer.
abstract: We investigated the association of the Osteopontin (OPN) (rs9138 and rs1126616) polymorphisms with colorectal cancer (CRC). One hundred CRC patients and 112 healthy individuals were subjected to OPN (rs9138 and rs1126616) genotyping and measurement of OPN protein plasma level. The C allele of OPN rs1126616 and the CC haplotype were significantly higher in CRC patient (p = 0.036, 0.003, respectively). In females, the C allele of OPN rs9318 (A/C) polymorphism was significantly associated with increased CRC risk (p = 0.036). The plasma OPN level >104.35 ng/mL was significantly associated with CRC. Our findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis.
authors.affiliation: a Department of Clinical & Chemical Pathology , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Asmaa
authors.initials: A
authors.lastname: Kamal
authors.affiliation: a Department of Clinical & Chemical Pathology , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Rania Kamal
authors.initials: RK
authors.lastname: Darwish
authors.affiliation: a Department of Clinical & Chemical Pathology , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Samar
authors.initials: S
authors.lastname: Saad
authors.affiliation: b Department of Surgical Oncology , National Cancer Institute, Cairo Univeristy , Cairo , Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Salama
authors.affiliation: b Department of Surgical Oncology , National Cancer Institute, Cairo Univeristy , Cairo , Egypt.
authors.forename: Tarek S
authors.initials: TS
authors.lastname: El-Baradie
authors.affiliation: b Department of Surgical Oncology , National Cancer Institute, Cairo Univeristy , Cairo , Egypt.
authors.forename: Heba G M
authors.initials: HG
authors.lastname: Mahmoud
authors.affiliation: a Department of Clinical & Chemical Pathology , Faculty of Medicine, Cairo University , Cairo , Egypt.
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Elshiwy
mesh_terms: D000367:Age Factors; D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C506895:SPP1 protein, human; D053495:Osteopontin
keywords: Colorectal cancer; Gene polymorphism; OPN rs1126616; OPN rs9138; Osteopontin