title: Associations of killer cell immunoglobulin-like receptors with acute myeloid leukemia in Chinese populations.
abstract: Many studies have investigated the relationship between KIR, HLA and acute myeloid leukemia (AML), but the results were different in different laboratories, and the data in Chinese population were limited. In this study, the distribution of KIR gene, KIR genotypes, HLA-C groups, HLA-Bw4, and KIR-HLA interaction from 273 healthy participants and 253 AML patients (M0-M6) in southern Chinese Han were determined to investigate the relationships among KIR, HLA and AML. The results showed that the frequencies of 2DS4del in M5 patients were significantly higher than those of the controls (65.0% vs 46.5%, P=0.0104, OR=2.135, P<ɑ'). The frequency of KIR genotype BX13 in the healthy controls was significantly higher than that in AML patients (3.7% vs 0%, P=0.0019, OR=20.2, P<ɑ'). No other significant differences in the frequencies of KIR, HLA and KIR-HLA interaction were identified between AML patients and controls. Our study suggests that 2DS4del may conduct a susceptibility to AML, and genotype BX13 might conduct a protective effect on AML.
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Sudan
authors.initials: S
authors.lastname: Tao
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: He
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Lina
authors.initials: L
authors.lastname: Dong
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Junjun
authors.initials: J
authors.lastname: He
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Nanying
authors.initials: N
authors.lastname: Chen
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Zhedong
authors.initials: Z
authors.lastname: Han
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Ji
authors.initials: J
authors.lastname: He
authors.affiliation: Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China. Electronic address: zfm00@hotmail.com.
authors.forename: Faming
authors.initials: F
authors.lastname: Zhu
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000208:ethnology / Q000235:genetics*; D008024:Ligands; D016133:Polymerase Chain Reaction / Q000379:methods; D020033:Protein Isoforms / Q000235:genetics; D054340:Receptors, KIR / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D008024:Ligands; D020033:Protein Isoforms; D054340:Receptors, KIR
keywords: Acute myeloid leukemia; HLA; KIR