title: [Mucosal healing in different intestinal segments in patients receiving infliximab treatment for small bowel Crohn's disease].
abstract: To evaluate the mucosal healing in the terminal ileum, colon and small bowel in patients receiving infliximab treatment for small bowel Crohn's disease (SBCD).
  
  
  
  The clinical data of 18 patients with SBCD treated with infliximab were analyzed for laboratory findings (routine blood tests, C-reative protein, and albumin), Crohn's disease activity index (CDAI), Lewis score (LS), Crohn's disease simplified endoscopic score (SES-CD) and adverse effects before and after 30 weeks of infliximab treatment.
  
  
  
  SES-CD, LS, CDAI and CRP were all decreased significantly, but the body mass index and albumin were significantly increased in the 18 patients after 30 weeks of IFX treatment. Sixteen (88.9%) of the patients were in clinical remission, 10 (58.8%) showed terminal ileum and colonic mucosal healing, 4 (22.2%) showed small bowel mucosal healing, and 3 (17.6%) were in deep remission. The 4 patients with small bowel mucosal healing all showed terminal ileum and colon mucosal healing, and 6 patients with terminal ileum and colon mucosal healing did not show small bowel mucosal healing.
  
  
  
  Infliximab treatment can effectively reduce inflammatory activity, induce and maintain clinical remission of SBCD and achieve mucosal healing; small bowel mucosal healing occurs later than terminal ileum and colonic mucosal healing, indicating the importance of small bowel mucosal healing in efficacy analysis of the treatment.
authors.affiliation: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: xiaozhuzhenhao@126.com.
authors.forename: Zhen-Hao
authors.initials: ZH
authors.lastname: Zhu
authors.forename: Chen
authors.initials: C
authors.lastname: Qiu
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiang
authors.forename: Xin-Ying
authors.initials: XY
authors.lastname: Wang
mesh_terms: D003108:Colonic Diseases / Q000188:drug therapy*; D003424:Crohn Disease / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007077:Ileal Diseases / Q000188:drug therapy*; D000069285:Infliximab / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000187:drug effects*; D007421:Intestine, Small; D012074:Remission Induction; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D000069285:Infliximab