title: The Effect of Fluphenazine and Thioridazine onToxoplasma gondiiIn Vivo.
abstract: BACKGROUND
  Toxoplasma gondiiis the most common parasite causing latent cerebral infections in human. It has been shown that some anti-psychotic drugs are able to inhibit the proliferation of the parasite in in vitro study. There is very limited data regarding the inhibitory effect of anti-psychotics on Toxoplasma in in vivo. In this study, we evaluated anti-Toxoplasmaactivity of fluphenazine and thioridazine drugs onT. gondiiin mice.
  
  
  METHODS
  Mice were divided into six groups: Control, sesame as vehicle, thioridazine 10 mg/kg, thioridazine 20 mg/kg, fluphenazine 0.06 mg/kg and fluphenazine 0.6 mg/kg. They were inoculated intraperitoneally with brain suspension containing tissue cysts ofT. gondiiTehran strain. Two months after inoculation, the number of cysts in crushed smears of mice brain were counted microscopically and considered as an indicator of anti-Toxoplasmaactivity. This work has conducted in Qazvin, central Iran, 2014.
  
  
  RESULTS
  Our study showed that fluphenazine and thioridazine could not significantly inhibit the brain cystogenesis ofT. gondiiin mice. However, the number of brain cysts was less at higher dose compared to lower doses for both drugs.
  
  
  CONCLUSIONS
  Further studies need to clear the mechanism of different structure of anti-psychotic drugs on activity ofToxoplasma.
authors.affiliation: Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran; Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Mehrzad
authors.initials: M
authors.lastname: Saraei
authors.affiliation: Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Yosef
authors.initials: Y
authors.lastname: Ghaderi
authors.affiliation: Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Mosavi
authors.affiliation: Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran; Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Shahnazi
authors.affiliation: Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran; Dept. of Pharmacology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Nassiri-Asl
authors.affiliation: Dept. of Community Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Jahanihashemi
keywords: Brain cysts; Fluphenazine; In vivo; Thioridazine; Toxoplama gondii