title: Rotating night shift work, sleep, and colorectal adenoma in women.
abstract: OBJECTIVE
  This study aims to investigate the associations of rotating night shift work history and sleep duration with risk of colorectal adenoma.
  
  
  METHODS
  We evaluated 56,275 cancer-free participants of the Nurses' Health Study II, who had their first colonoscopy or sigmoidoscopy between 1991 and 2011; rotating night shift work and sleep duration were reported by mailed questionnaire. Multivariable-adjusted logistic regression was used to estimate relative risks (RR) of colorectal adenoma, with 95% confidence intervals (CI), across categories of rotating night shift work history (none, 1-4, 5-9, and ≥10 years) and sleep duration (≤5, 6, 7, 8, and ≥9 h/day).
  
  
  RESULTS
  We found no association between duration of rotating night shift work and occurrence of colorectal adenoma (p-trend across shift work categories = 0.5). Women with the longest durations of rotating night shift work (≥10 years) had a similar risk of adenoma compared to women without a history of rotating night shift work (multivariable-adjusted RR = 0.96, 95% CI = 0.83-1.11). Similarly, there were no associations of shorter or longer sleep durations with adenoma risk (p-trend = 0.2 across sleep durations of ≤5 through 7 h/day and p-trend = 0.5 across sleep durations of 7 through ≥9 h/day). Results were similar when we examined associations according to adenoma location and subtype.
  
  
  CONCLUSIONS
  Our results do not support an association between rotating night shift work or sleep duration and risk of colorectal adenoma in women.
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA. nheed@channing.harvard.edu.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Devore
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Massa
authors.affiliation: Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Papantoniou
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA.|Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Eva S
authors.initials: ES
authors.lastname: Schernhammer
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Kana
authors.initials: K
authors.lastname: Wu
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA.|Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Walter C
authors.initials: WC
authors.lastname: Willett
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA.|Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Fuchs
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA.|Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Chan
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.|Division of MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Shuji
authors.initials: S
authors.lastname: Ogino
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA.|Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Giovannucci
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA.|California Pacific Medical Center Research Institute, San Francisco, CA, USA.
authors.forename: Esther K
authors.initials: EK
authors.lastname: Wei
mesh_terms: D000236:Adenoma / Q000453:epidemiology*; D000328:Adult; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012306:Risk; D012307:Risk Factors; D000073577:Shift Work Schedule / Q000706:statistics & numerical data*; D012890:Sleep
keywords: Adenoma; Colonoscopy; Polyps; Rotating night shift work; Sleep; Women