title: Epidemiology update for hepatitis C virus and hepatitis B virus in end-stage renal disease in France.
abstract: Risk for HCV/HBV infection is increased in end-stage renal disease patients. We generate updated epidemiological data.
  
  
  
  Based on the National French registry for end-stage renal disease patients, we extracted data for patients who started dialysis or pre-emptive transplantation between January 2005 and December 2013. A positive serum HBs Ag and/or a positive HCV RNA defined HBV and HCV infections, respectively.
  
  
  
  In all, 72 948 patients were included among which 62.5% were men. At inclusion, 615 patients were HBV+ and 1026 HCV+. The prevalence of HBV and HCV infections were 0.84% (95% PI: 0.78-0.91) and 1.41% (95% PI: 1.32-1.49), respectively. The prevalence of HBV infection by age group increased progressively until a maximum rate at 1.80% (95% PI: 1.46-2.20) in the 4th decade, then regularly decreased. Same profile was observed for HCV prevalence, with a maximum rate at 3.14% (95% PI: 2.68-3.65) in the 4th decade. During the follow-up, we identified new HBV or HCV infections in 117 and 81 patients, respectively, with an overall incidence of 0.076% (95% PI: 0.062-0.090) and 0.053% (95%PI: 0.041-0.065) between 2005 and 2013, respectively. During the first dialysis year, HBV incidence was 0.35% (95% PI: 0.28-0.43) and that of HCV 0.21% (95% PI: 0.16-0.28).
  
  
  
  Our data highlight the need for HCV therapy for more than 1000 end-stage renal disease patients in France, sustained systematic immunization campaigns (HBV) and underlines the persistence of HBV/HCV new hand-borne nosocomial cases.
authors.affiliation: Department of Nephrology, Urology and Transplantation, Pitié-Salpêtrière Hospital, Sorbonne University, Univ. Paris 6, Paris, France.
authors.forename: Corinne
authors.identifier: 0000-0002-1048-6636
authors.initials: C
authors.lastname: Isnard Bagnis
authors.affiliation: REIN Registry, Agence de Biomedecine, Saint Denis La Plaine, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Couchoud
authors.affiliation: Nephrology Department, La Miletrie Hospital, Poitiers, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Bowens
authors.affiliation: Polyclinique Saint Côme, Compiègne, France.
authors.forename: Ayman
authors.initials: A
authors.lastname: Sarraj
authors.affiliation: Department of Nephrology, Urology and Transplantation, Pitié-Salpêtrière Hospital, Sorbonne University, Univ. Paris 6, Paris, France.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Deray
authors.affiliation: Department of Nephrology, Urology and Transplantation, Pitié-Salpêtrière Hospital, Sorbonne University, Univ. Paris 6, Paris, France.|IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Tourret
authors.affiliation: Department of Internal Medicine and Clinical Immunology, Paris, France.|Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne University, UPMC Univ Paris 06, UMR 7211, Paris, France.|INSERM, UMR_S 959, Paris, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.affiliation: Sorbonne University, UPMC Univ Paris 06 UMR_S1136, Paris, France.|INSERM UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.|Biostatistics Unit, Pitie-Salpêtrière Hospital, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Tezenas du Montcel
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D016174:Hepacivirus / Q000235:genetics; D006509:Hepatitis B / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006526:Hepatitis C / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D012042:Registries; D006435:Renal Dialysis / Q000009:adverse effects; D017678:Sex Distribution; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies
keywords: dialysis; hepatitis B; hepatitis C; transplantation