title: Selective Aza Diels-Alder and Domino [4+2]/[2+2] Cycloaddition Reactions of Arynes with N-Sulfonyl Ketimines.
abstract: Transition-metal-free inverse electron-demand aza Diels-Alder and domino [4+2]/[2+2] cycloaddition reaction of arynes and N-sulfonyl ketimines has been demonstrated. This novel, mild, and efficient protocol allows rapid access to isothiazole dioxide-fused dihydroquinoline or dihydrocyclobutaquinoline derivatives selectively by simply varying the equivalents of aryne precursors. The application of this method has been amply illustrated in the synthesis of 2,4-diarylquinolines.
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Rd., Shapingba, Chongqing 401331, P.R. China.
authors.forename: I N Chaithanya
authors.initials: IN
authors.lastname: Kiran
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Rd., Shapingba, Chongqing 401331, P.R. China.
authors.forename: R Santhosh
authors.initials: RS
authors.lastname: Reddy
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Rd., Shapingba, Chongqing 401331, P.R. China.
authors.forename: Chandraiah
authors.initials: C
authors.lastname: Lagishetti
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Rd., Shapingba, Chongqing 401331, P.R. China.
authors.forename: Huacheng
authors.initials: H
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Rd., Shapingba, Chongqing 401331, P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Rd., Shapingba, Chongqing 401331, P.R. China.
authors.forename: Yun
authors.identifier: 0000-0002-5322-7300
authors.initials: Y
authors.lastname: He