title: In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor.
abstract: The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.
authors.affiliation: Department of Chemistry, Lakehead University, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.|Thunder Bay Regional Research institute, 980 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
authors.forename: Francis T
authors.initials: FT
authors.lastname: Hane
authors.affiliation: Department of Chemistry, Lakehead University, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Chemistry, Lakehead University, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Smylie
authors.affiliation: Department of Chemistry, Lakehead University, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.|Thunder Bay Regional Research institute, 980 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
authors.forename: Raiili M
authors.initials: RM
authors.lastname: Pellizzari
authors.affiliation: Department of Chemistry, Lakehead University, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.|Thunder Bay Regional Research institute, 980 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Plata
authors.affiliation: Department of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston RI 02881, USA.
authors.forename: Brenton
authors.initials: B
authors.lastname: DeBoef
authors.affiliation: Department of Chemistry, Lakehead University, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.|Thunder Bay Regional Research institute, 980 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.|Northern Ontario School of Medicine, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Albert
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000000981:diagnostic imaging*; D001952:Bridged-Ring Compounds / Q000032:analysis*; D003287:Contrast Media / Q000032:analysis*; D007093:Imidazoles / Q000032:analysis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051381:Rats; D014979:Xenon Isotopes / Q000032:analysis*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D003287:Contrast Media; D007093:Imidazoles; D014979:Xenon Isotopes; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils