title: Germinated and Ungerminated Seeds Extract from TwoLupinusSpecies: Biological Compounds Characterization and In Vitro and In Vivo Evaluations.
abstract: In recent years, nutraceuticals attracted a great amount of attention in the biomedical research due to their significant contribution as natural agents for prevention of various health issues. Ethanolic extracts from the ungerminated and germinated seeds ofLupinus albusL. andLupinus angustifoliusL. were analyzed for the content in isoflavones (genistein) and cinnamic acid derivatives. Additionally, the extracts were evaluated for antimicrobial, antiproliferative, and anti-inflammatory properties, using in vitro and in vivo tests. Germination proved to be a method of choice in increasing the amount of genistein and cinnamic acid derivatives in bothLupinus albusL. andLupinus angustifolius L.seeds. Biological evaluation of all vegetal extracts revealed a weak therapeutic potential for both ungerminated and germinated seeds.
authors.affiliation: Department of Orthopedics, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Andor
authors.affiliation: Department of Pharmacognosy, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Corina
authors.identifier: 0000-0001-5999-1214
authors.initials: C
authors.lastname: Danciu
authors.affiliation: Department of Food Control, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Calea Aradului No. 119, 300641 Timisoara, Romania.
authors.forename: Ersilia
authors.initials: E
authors.lastname: Alexa
authors.affiliation: Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged 6720, Hungary.
authors.forename: Istvan
authors.identifier: 0000-0003-3243-5300
authors.initials: I
authors.lastname: Zupko
authors.affiliation: Department of Microbiology-Virology, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Elena
authors.initials: E
authors.lastname: Hogea
authors.affiliation: Department of Pathology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
authors.forename: Andreea
authors.identifier: 0000-0003-2215-6666
authors.initials: A
authors.lastname: Cioca
authors.affiliation: Department of Toxicology, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Dorina
authors.initials: D
authors.lastname: Coricovac
authors.affiliation: Department of Toxicology, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Iulia
authors.identifier: 0000-0003-2295-1926
authors.initials: I
authors.lastname: Pinzaru
authors.affiliation: Department of Orthopedics, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Jenel Marian
authors.initials: JM
authors.lastname: Pătrașcu
authors.affiliation: Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Mioc
authors.affiliation: Department of Pharmacology and Pharmacy, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Calea Aradului No. 119, 300641 Timisoara, Romania.
authors.forename: Romeo Teodor
authors.initials: RT
authors.lastname: Cristina
authors.affiliation: Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Codruta
authors.initials: C
authors.lastname: Soica
authors.affiliation: Department of Toxicology, University of Medicine and Pharmacy "Victor Babeş", Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Dehelean