title: Neutropenic acute acalculous cholecystitis (AAC) in a 12-year-old boy with T-acute lymphoblastic leukemia successfully managed with conservative treatment.
abstract: Acute acalculous cholecystitis (AAC) is an inflammation of the gallbladder without the presence of gallstones. In children with malignancies or chemotherapy-induced neutropenia, AAC is very rare. Clinical diagnosis of AAC remains difficult in this patient population but an early recognition followed by an appropriate intervention may confer a benefit. Only three pediatric patients with underlying hematological malignancies whose clinical treatment course was complicated by the development of AAC have been described. We describe a neutropenic pediatric patient who developed AAC following chemotherapy for acute T-cell acute lymphoblastic leukemia (T-ALL), which was successfully managed with conservative treatment.
  
  
  BACKGROUND
  AAC: Acute acalculous cholecystitis; T-ALL: T-cell acute lymphoblastic leukemia; TPN: Total parenteral nutrition.
authors.affiliation: a Division of Paediatric Infections Disease , Royal Aberdeen Children's Hospital , Aberdeen , UK.
authors.forename: Aldo
authors.initials: A
authors.lastname: Naselli
authors.affiliation: b Division of Paediatric Haemato-Oncology , Royal Aberdeen Children's Hospital , Aberdeen , UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Bishop
authors.affiliation: c Department of Radiology , Aberdeen Royal Infirmary , Aberdeen , UK.
authors.forename: Shonagh
authors.initials: S
authors.lastname: Walker
authors.affiliation: d Division of Paediatric Infectious Disease , Royal Aberdeen Children's Hospital , Aberdeen , UK.|e Institute of Medical Sciences , University of Aberdeen , Aberdeen , UK.
authors.forename: Adilia
authors.initials: A
authors.lastname: Warris
mesh_terms: D042101:Acalculous Cholecystitis / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
keywords: AAC; T-LLA; conservative management; neutropenic fever