title: Gimme a complex! Resident mononuclear phagocytes in the kidney as monitors of circulating antigens and immune complexes.
abstract: Over the past decade, researchers have made substantial progress in characterizing a network of mononuclear phagocytes in the kidney, which variously have been referred to as resident macrophages or dendritic cells. Two recent studies, published in Cell and Kidney International, have identified these resident macrophages/dendritic cells as local immune monitors of peritubular capillaries for circulating antigens and immune complexes. These cells appear to represent an early line of defense against circulating infectious particles and immune complexes, but the resulting inflammatory response may also contribute to interstitial inflammation and kidney disease progression.
authors.affiliation: Clinic for Nephrology and Hypertension, Christian-Albrechts-University, Kiel, Germany.
authors.forename: Wulf
authors.initials: W
authors.lastname: Tonnus
authors.affiliation: Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hugo
authors.affiliation: Clinic for Nephrology and Hypertension, Christian-Albrechts-University, Kiel, Germany; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. Electronic address: andreas.linkermann@uniklinikum-dresden.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Linkermann
mesh_terms: D000936:Antigen-Antibody Complex; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000276:immunology; D007674:Kidney Diseases; D008264:Macrophages / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex