title: The relationship of cognitive improvement after cognitive remediation with social functioning in patients with schizophrenia and severe cognitive deficits.
abstract: This study aims to examine the effects of change in neurocognition on functional outcomes and to examine predictors of change in social functions following a 12-week course of cognitive remediation in patients with schizophrenia and schizoaffective disorder with severe cognitive impairments.
  
  
  
  Level of social functioning was assessed using a performance based measure of functional capacity (PSP) in patients prior to and after the completion of 12-week cognitive remediation treatment (CRT). Participants completed a neuropsychological battery (MCCB-MATRICS) and clinical measures at both time points.
  
  
  
  63 subjects with a mean age of 41.4 (SD=12.2) and with 12.2years of education (SD=2.4) were enrolled. There were significant improvements in overall PSP score from baseline to endpoint (p=0.021) as well as in PSP domain A (socially useful activities) (p≤0.001), domain B (personal and social relationships) (p=0.009), and domain D (disturbing and aggressive behaviors) (p=0.003). There was a significant improvement in the composite MCCB score (p=0.020) and the Working Memory (p<0.046). Stepwise logistic regression yielded a significant association for baseline Visual Learning (Wald=6.537, p=0.011, OR=1.195), Speed of Processing (Wald=4.112, p=0.043, OR=0.850) and level of PANSS positive symptoms (Wald=4.087, p=0.043, OR=0.739) with PSP overall improvement.
  
  
  
  Faster speed of processing, better visual and verbal learning and less prominent positive symptoms were associated with greater functional improvement after a systematic cognitive intervention within a rehabilitative setting.
authors.affiliation: Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States; New York University, Department of Psychiatry, New York, NY, United States. Electronic address: Lindenmayer@nki.rfmh.org.
authors.forename: J P
authors.initials: JP
authors.lastname: Lindenmayer
authors.affiliation: Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States. Electronic address: sefreg13@g.holycross.edu.
authors.forename: Samantha
authors.initials: S
authors.lastname: Fregenti
authors.affiliation: Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: Guoxin.Kang1@gmail.com.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Kang
authors.affiliation: Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: VOzog@nki.rfmh.org.
authors.forename: Veronica
authors.initials: V
authors.lastname: Ozog
authors.affiliation: Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: ILjuri@nki.rfmh.org.
authors.forename: Isidora
authors.initials: I
authors.lastname: Ljuri
authors.affiliation: Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: AKhan@nki.rfmh.org.
authors.forename: Anzalee
authors.initials: A
authors.lastname: Khan
authors.affiliation: Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States. Electronic address: AGoldring@nki.rfmh.org.
authors.forename: A
authors.initials: A
authors.lastname: Goldring
authors.affiliation: Boston University, Boston, MA, United States. Electronic address: mgurk@bu.edu.
authors.forename: Susan R
authors.initials: SR
authors.lastname: McGurk
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000209:etiology* / Q000534:rehabilitation*; D000072466:Cognitive Remediation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents
keywords: Functioning; Neurocognition; Schizophrenia