title: Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle.
abstract: To determine oral transmissibility of the L-type bovine spongiform encephalopathy (BSE) prion, we orally inoculated 16 calves with brain homogenates of the agent. Only 1 animal, given a high dose, showed signs and died at 88 months. These results suggest low risk for oral transmission of the L-BSE agent among cattle.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Iwamaru
authors.forename: Morikazu
authors.initials: M
authors.lastname: Imamura
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Miyazawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Matsuura
authors.forename: Kentaro
authors.initials: K
authors.lastname: Masujin
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Murayama
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission*; D005260:Female; D007150:Immunohistochemistry; D011328:Prions / Q000378:metabolism
chemical_list: D011328:Prions
keywords: L-BSE; L-type; atypical bovine spongiform encephalopathy; cattle; oral transmission; prion; prions and related diseases; zoonoses