title: Health and functioning of adolescents conceived by assisted reproductive technology.
abstract: To evaluate the general health, mental health, and cognitive ability of assisted reproductive technology (ART)-conceived adolescents.
  
  
  
  A nested case-control study within a historic cohort.
  
  
  
  Not applicable.
  
  
  
  A total of 253 ART-conceived adolescents born between 1982 and 1993 and 253 matched references according to birth year, gender, and the high-school they attended.
  
  
  
  None.
  
  
  
  Medical and psychiatric diagnoses, and cognitive ability recorded at the military preinduction screening (ages 16-17 years) and doctor's appointments throughout the military service.
  
  
  
  No differences were detected in general and mental health of ART adolescents or cognitive ability, compared with the reference group. Similar results were obtained after stratification for gender and singleton births. The ART adolescents had fewer cases of discharge from military service due to health reasons (4% vs. 8.3%). Follow-up during the military service revealed that male ART adolescents had significantly more doctor's appointments compared with the reference group (23.80 ± 15.59 vs. 19.95 ± 13.79).
  
  
  
  Our preliminary results provide reassurance that in the long-run health and functioning of ART-conceived adolescents is not compromised. Further studies with larger cohorts are needed to confirm these results.
authors.affiliation: Israeli Defense Force Medical Corps., Department of Psychiatry, Rambam Medical Center; Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Eyal
authors.initials: E
authors.lastname: Fruchter
authors.affiliation: Department of Obstetrics and Gynecology, Ha'Emek Medical Center, Afula; Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Ronit
authors.initials: R
authors.lastname: Beck-Fruchter
authors.affiliation: Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Hourvitz
authors.affiliation: Department of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: mweiser@netvision.net.il.
authors.forename: Mark
authors.initials: M
authors.lastname: Weiser
authors.affiliation: Department of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
authors.forename: Shira
authors.initials: S
authors.lastname: Goldberg
authors.affiliation: Department of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
authors.forename: Daphna
authors.initials: D
authors.lastname: Fenchel
authors.affiliation: Women and Children's Health Research Unit, Gertner Institute for Epidemiology and Health Policy Research, Chaim Sheba Medical Center, Tel Hashomer; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Liat
authors.initials: L
authors.lastname: Lerner-Geva
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D041923:Adolescent Development; D000067697:Adolescent Health; D000367:Age Factors; D003071:Cognition; D005260:Female; D006304:Health Status; D006801:Humans; D007557:Israel; D050498:Live Birth; D008297:Male; D008603:Mental Health; D008889:Military Personnel; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Assisted reproduction technology (ART); adolescents; follow-up; health