title: The combined use of Drug-eluting balloon and Excimer laser for coronary artery Restenosis In-Stent Treatment: The DERIST study.
abstract: OBJECTIVE
  Stents reduce angiographic restenosis in comparison with balloon angioplasty. The rate of in-stent restenosis (ISR), although less frequent than post-angioplasty restenosis, is becoming increasingly prevalent due to the recent exponential increase in the use of intracoronary stents. The aim of this study is to evaluate angiographic and clinical outcomes of PTCA in combination with the use of excimer laser coronary angioplasty (ELCA) and drug-eluting balloon (DEB) in treatment of in-stent restenosis (ISR).
  
  
  RESULTS
  This multi-centric case-control study evaluated angiographic and clinical outcomes of PTCA with excimer laser coronary angioplasty (ELCA) and drug-eluting balloon (DEB) in 80 patients with in-stent restenosis (ISR). All patients underwent nine months of clinical and a coronary angiography follow-up. This study showed clinical and angiographic long-term success in the 91% of the patients. The incidence of myocardial infarctions and deaths was lower than the rate after plain balloon angioplasty within the stent.
  
  
  CONCLUSIONS
  This study showed that excimer laser coronary angioplasty (ELCA) and drug-eluting balloon (DEB) may be an alternative treatment for in-stent restenosis (ISR).
authors.affiliation: Montevergine Clinic, Mercogliano, Avellino, Italy; Ospedale S. Moscati, Avellino, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Ambrosini
authors.affiliation: Montevergine Clinic, Mercogliano, Avellino, Italy; Ospedale Moriggia-Pelascini, Gravedona, Como. Electronic address: lucagolino.jazz@alice.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Golino
authors.affiliation: Policlinico A. Gemelli, Rome, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Niccoli
authors.affiliation: Internal Medicine Department, La Tour Hospital, Meyrin, Switzerland.
authors.forename: Marco
authors.initials: M
authors.lastname: Roberto
authors.affiliation: Azienda Ospedaliera S. Carlo, Potenza, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Lisanti
authors.affiliation: A.O. Pugliese-Ciaccio, Catanzaro, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ceravolo
authors.affiliation: Azienda Ospedaliera. S.M. della Misericordia, Udine, Italy.
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Bernardi
authors.affiliation: Istituto Italiano Ricerche Mediche, Verona, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Armigliato
authors.affiliation: Azienda Ospedaliera Ospedali Riuniti, Ancona, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Gabrielli
authors.affiliation: Ospedale "Spedali Civili", Brescia, Italy.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Chizzola
authors.affiliation: Dipartimento Cure Primarie, ATS Brianza, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: De Paulis
authors.affiliation: Policlinico A. Gemelli, Rome, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
authors.affiliation: Ospedale San Raffaele, Milan, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
mesh_terms: D000328:Adult; D000368:Aged; D017222:Angioplasty, Balloon, Laser-Assisted / Q000009:adverse effects / Q000295:instrumentation*; D062906:Cardiac Catheters; D016022:Case-Control Studies; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D007558:Italy; D054018:Lasers, Excimer / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011446:Prospective Studies; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible
keywords: Drug Eluting Balloon (DEB); Excimer Laser Coronary Angioplasty (ELCA); In-stent restenosis (ISR)