title: Mechanistic Insight of Probiotics Derived Anticancer Pharmaceuticals: A Road Forward for Cancer Therapeutics.
abstract: Probiotics are living organisms that confer health benefits when administered in adequate amounts. Probiotics are continuously being explored for their different health beneficiary activities. Anticancer activity is one of the most important benefits both from a preventive and therapeutic point of view. Though not many studies have been conducted to date in this area, a number suggest using laboratory animal models and different cell lines that there may be a mechanistic basis for the anticancer effects of probiotics and require more scientific justification and clinical trials. Most studies of probiotics are conducted for colon cancer associated with inflammatory bowel disease. Studies are also being extended to other types of cancer in different cell lines. This review summarizes studied probiotics considered for treatment of colon cancer and some other cancers (in cancer cell lines) and also proposed mechanism how probiotics are inhibiting cancer growth along with some challenges and future perspectives.
authors.affiliation: a Department of Biochemistry , Kurukshetra University , Kurukshetra , India.
authors.forename: Raman
authors.initials: R
authors.lastname: Kumar
authors.affiliation: a Department of Biochemistry , Kurukshetra University , Kurukshetra , India.
authors.forename: Suman
authors.initials: S
authors.lastname: Dhanda
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004249:DNA Damage; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System / Q000378:metabolism; D019216:Metals, Heavy / Q000378:metabolism; D019936:Probiotics / Q000627:therapeutic use*
chemical_list: D019216:Metals, Heavy