title: Increased Arf/p53 activity in stem cells, aging and cancer.
abstract: Arf/p53 pathway protects the cells against DNA damage induced by acute stress. This characteristic is the responsible for its tumor suppressor activity. Moreover, it regulates the chronic type of stress associated with aging. This is the basis of its anti-aging activity. Indeed, increased gene dosage of Arf/p53 displays elongated longevity and delayed aging. At a cellular level, it has been recently shown that increased dosage of Arf/p53 delays age-associated stem cell exhaustion and the subsequent decline in tissue homeostasis and regeneration. However, p53 can also promote aging if constitutively activated. In this context, p53 reduces tissue regeneration, which correlates with premature exhaustion of stem cells. We discuss here the current evidence linking the Arf/p53 pathway to the processes of aging and cancer through stem cell regulation.
authors.affiliation: Cellular Oncology Group, Biodonostia Institute, San Sebastian, Spain.
authors.forename: Estefania
authors.initials: E
authors.lastname: Carrasco-Garcia
authors.affiliation: Cellular Oncology Group, Biodonostia Institute, San Sebastian, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Moreno
authors.affiliation: Cellular Oncology Group, Biodonostia Institute, San Sebastian, Spain.
authors.forename: Leire
authors.initials: L
authors.lastname: Moreno-Cugnon
authors.affiliation: Cellular Oncology Group, Biodonostia Institute, San Sebastian, Spain.|Ikerbasque, Basque Foundation, Bilbao, Spain.
authors.forename: Ander
authors.initials: A
authors.lastname: Matheu
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D016159:Tumor Suppressor Protein p53
keywords: ARF; aging; p16; p53; stem cells