title: Efficient Variational Approach to Multimodal Registration of Anatomical and Functional Intra-Patient Tumorous Brain Data.
abstract: This paper addresses the functional localization of intra-patient images of the brain. Functional images of the brain (fMRI and PET) provide information about brain function and metabolism whereas anatomical images (MRI and CT) supply the localization of structures with high spatial resolution. The goal is to find the geometric correspondence between functional and anatomical images in order to complement and fuse the information provided by each imaging modality. The proposed approach is based on a variational formulation of the image registration problem in the frequency domain. It has been implemented as a C/C[Formula: see text] library which is invoked from a GUI. This interface is routinely used in the clinical setting by physicians for research purposes (Inscanner, Alicante, Spain), and may be used as well for diagnosis and surgical planning. The registration of anatomic and functional intra-patient images of the brain makes it possible to obtain a geometric correspondence which allows for the localization of the functional processes that occur in the brain. Through 18 clinical experiments, it has been demonstrated how the proposed approach outperforms popular state-of-the-art registration methods in terms of efficiency, information theory-based measures (such as mutual information) and actual registration error (distance in space of corresponding landmarks).
authors.affiliation: * Universidad Politécnica de Cartagena, Plaza del Hospital, 1. Cartagena, 30202, Spain.
authors.forename: Alvar-Ginés
authors.initials: AG
authors.lastname: Legaz-Aparicio
authors.affiliation: * Universidad Politécnica de Cartagena, Plaza del Hospital, 1. Cartagena, 30202, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Verdú-Monedero
authors.affiliation: * Universidad Politécnica de Cartagena, Plaza del Hospital, 1. Cartagena, 30202, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Larrey-Ruiz
authors.affiliation: * Universidad Politécnica de Cartagena, Plaza del Hospital, 1. Cartagena, 30202, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Morales-Sánchez
authors.affiliation: † Universidad Politécnica de Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: López-Mir
authors.affiliation: † Universidad Politécnica de Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
authors.forename: Valery
authors.initials: V
authors.lastname: Naranjo
authors.affiliation: ‡ Inscanner S.L., Unidad de Resonancia Magnética, Avenida de Dénia, 78. Alicante, 03016, Spain.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Bernabéu
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods; D059906:Neuroimaging / Q000379:methods*
keywords: Image registration; brain imaging; brain registration; functional localization; multimodal registration; variational registration