title: Diverse functions for different forms of nuclear actin.
abstract: In addition to its essential roles as part of the cytoskeleton, actin has also been linked to many processes in the nucleus. Recent data has demonstrated the presence of both monomeric and polymeric actin in the nucleus, and implied distinct functional roles for these actin pools. Monomeric actin seems to be involved in regulation of gene expression through transcription factors, chromatin regulating complexes and RNA polymerases. In addition to cytoplasmic actin regulators, nuclear proteins, such as emerin, can regulate actin polymerization properties specifically in this compartment. Besides of structural roles, nuclear actin filaments may be required for organizing the nuclear contents and for the maintenance of genomic integrity.
authors.affiliation: Institute of Biotechnology, University of Helsinki, Viikinkaari 5, 00790 Helsinki, Finland.
authors.forename: Jori A
authors.initials: JA
authors.lastname: Virtanen
authors.affiliation: Institute of Biotechnology, University of Helsinki, Viikinkaari 5, 00790 Helsinki, Finland. Electronic address: maria.vartiainen@helsinki.fi.
authors.forename: Maria K
authors.initials: MK
authors.lastname: Vartiainen
mesh_terms: D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000199:Actins; D002843:Chromatin; D009687:Nuclear Proteins