title: Juvenile systemic lupus erythematosus (jSLE): Auditory pathway affection in relation to disease activity.
abstract: BACKGROUND
  Juvenile Systemic lupus erythematosus (jSLE) is an autoimmune disease with the potential to affect a variety of organs in children or adolescents. jSLE is characterized by its severity and more widespread organ involvement specially central nervous system.
  
  
  OBJECTIVE
  To evaluate auditory processing and cognitive functions in children and adolescents with SLE taking into consideration the disease severity.
  
  
  METHODS
  This work included 40 normal hearing pediatric patients diagnosed as SLE (23 with active disease and 17 with inactive disease) and a control group included 30 matched healthy children. The methodology included basic audiologic evaluation, mismatch negativity (MMN) in response to speech and tone stimuli and memory tests.
  
  
  RESULTS
  Children with jSLE showed impaired hearing thresholds. They also showed impaired MMN recording in response to speech or tone stimuli with impaired memory subtests.
  
  
  CONCLUSIONS
  Peripheral and central auditory systems are affected in jSLE. This affection is worse with active disease.
authors.affiliation: Audiology Unit, Otolaryngology Head and Neck Surgery Department, Faculty of Medicine, Tanta University, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Kotait
authors.affiliation: Pediatric Department, Faculty of Medicine, Tanta University, Egypt.
authors.forename: H H
authors.initials: HH
authors.lastname: Abd Elnabi
authors.affiliation: Audiology Unit, Otolaryngology Head and Neck Surgery Department, Faculty of Medicine, Tanta University, Egypt. Electronic address: takwagabr@gmail.com.
authors.forename: T A
authors.initials: TA
authors.lastname: Gabr
mesh_terms: D000293:Adolescent; D001306:Auditory Pathways / Q000503:physiopathology*; D001309:Auditory Threshold / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology*
keywords: Cognitive function; Disease activity; Juvenile systemic lupus erythematosus (jSLE); Mismatch negativity; SLEDAI