title: Hepatitis C virus reactivation due to antiemetic steroid therapy during treatment of hepatocellular carcinoma.
abstract: Hepatitis C virus (HCV) reactivation is relatively rare compared with hepatitis B reactivation in patients treated with immunosuppressive or anticancer drugs. Here, we present the first case of genotype 2 HCV reactivation due to antiemetic steroid therapy during chemotherapy for hepatocellular carcinoma (HCC), which was verified by not only increased viral load but also pathological exacerbation of liver injury during HCV reactivation. Further chemotherapy for HCC could be continued without steroid therapy. This present case highlights the awareness of HCV reactivation and the management of complex situation.
authors.affiliation: Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan; Department of Infection Control, and Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan. Electronic address: ykawano@sapmed.ac.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kawano
authors.affiliation: Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Miyanishi
authors.affiliation: Department of Infection Control, and Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kubo
authors.affiliation: Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ishikawa
authors.affiliation: Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Sugita
authors.affiliation: Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan; Department of Hematology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Kohichi
authors.initials: K
authors.lastname: Takada
authors.affiliation: Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan; Department of Hematology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.affiliation: Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan; Department of Hematology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
mesh_terms: D000368:Aged; D000932:Antiemetics / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000821:virology; D005260:Female; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000821:virology; D013256:Steroids / Q000009:adverse effects* / Q000627:therapeutic use; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D013256:Steroids
keywords: Antiemetic therapy; Dexamethasone; Genotype 2; Hepatitis C virus reactivation; Hepatocellular carcinoma