title: Persistent organic pollutants (POPs) in human follicular fluid and in vitro fertilization outcomes, a pilot study.
abstract: Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF). We identified significant inverse associations between higher levels of PCB congeners and indicators of ovarian reserve (e.g., antral follicle count), follicular response to administered gonadotropins (e.g., peak estradiol, number of oocytes retrieved, endometrial thickness), intermediate IVF endpoints (e.g., oocyte fertilization and embryo quality), and clinical IVF outcomes (e.g., embryo implantation and live birth), after adjusting for body mass index, cigarette smoking, race, and age. Our results suggest that ongoing exposure to POPs impacts IVF and merit confirmation in a larger and more definitive future study.
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address: mbloom@albany.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bloom
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA, USA.
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Fujimoto
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Storm
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
authors.forename: Celeste D
authors.initials: CD
authors.lastname: Butts
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Sollohub
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Jansing
mesh_terms: D003634:DDT / Q000032:analysis* / Q000633:toxicity; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis* / Q000633:toxicity; D010064:Embryo Implantation / Q000187:drug effects; D004785:Environmental Pollutants / Q000032:analysis* / Q000633:toxicity; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D015999:Multivariate Analysis; D010865:Pilot Projects; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000633:toxicity; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology
chemical_list: D004785:Environmental Pollutants; D003633:Dichlorodiphenyl Dichloroethylene; D003634:DDT; D011078:Polychlorinated Biphenyls
keywords: Dichlorodiphenyldichloroethylene (DDE); Dichlorodiphenyltrichloroethane (DDT); Follicular fluid; In vitro fertilization (IVF); Infertility; Organochlorine pesticides; Persistent organic pollutants (POPs); Polychlorinated biphenyls (PCBs); Reproduction