title: Surfactant-Free Preparation of Au@Resveratrol Hollow Nanoparticles with Photothermal Performance and Antioxidant Activity.
abstract: Nanocomposites based on hollow Au nanostructures have gained considerable attention in theranostics applications because of their unique plasmonic structures and attractive physicochemical properties. The exploration of feasible and facile methods for constructing multifunctional nanocomposites combined with bioactive molecules is greatly needed for the development of multifunctional theranostics platforms. In this work, resveratrol, a natural polyphenol with antioxidant activity and cancer-chemopreventive propertyies is employed as the reducing agent cum coating agent for the surfactant-free preparation of Au@resveratrol hollow NPs (Au@Res HNPs). The as-prepared Au@Res HNPs were found to present good photothermal performance and chemical inhibition for cancer therapy. In vitro experiments indicated that the Au@Res HNPs can block cell cycles to inhibit cell division and lead to cell apoptosis after 808-nm laser irradiation. Because no toxic surfactants are introduced, the current protocol avoids the tedious surfactant separation and surface modification processes that are necessary for most theranostics materials.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Stomatology, Jilin University , Changchun 130041, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Tang
authors.forename: Tianrong
authors.initials: T
authors.lastname: Yu
authors.affiliation: School of Stomatology, Jilin University , Changchun 130041, P. R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yi
authors.identifier: http://orcid.org/0000-0003-0548-6073
authors.initials: Y
authors.lastname: Liu
authors.affiliation: First Hospital of Jilin University, Jilin University , Changchun 130021, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Rong
authors.forename: Zhigang
authors.identifier: http://orcid.org/0000-0002-3028-5196
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Stomatology, Jilin University , Changchun 130041, P. R. China.
authors.forename: Hongchen
authors.identifier: http://orcid.org/0000-0002-5572-508X
authors.initials: H
authors.lastname: Sun
authors.forename: Hao
authors.identifier: http://orcid.org/0000-0002-2373-1100
authors.initials: H
authors.lastname: Zhang
authors.forename: Bai
authors.identifier: http://orcid.org/0000-0002-3873-075X
authors.initials: B
authors.lastname: Yang
mesh_terms: D000975:Antioxidants; D006046:Gold; D053768:Metal Nanoparticles / Q000737:chemistry*; D000077185:Resveratrol; D013267:Stilbenes; D013501:Surface-Active Agents
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D013501:Surface-Active Agents; D006046:Gold; D000077185:Resveratrol
keywords: antioxidant activity; hollow Au nanoparticles; nanocomposites; photothermal therapy; resveratrol