title: Lycopene in the Prevention of Radiation-Induced Esophagitis.
abstract: We aimed to research whether lycopene (L) could prevent radiation-induced acute esophageal toxicity in Wistar albino rats. 60 rats were placed in five groups as follows: control, L, radiotherapy (RT), L before RT (L + RT), and L before and after RT (L + RT + L). 6 mg/kg bw/day L was administered 7 days in the L group, 7 days before RT in the L + RT group, and 7 days before and after in the L + RT + L group. 35 Gy thoracic RT was performed. Serum L levels were measured, and the esophagi were evaluated histopathologically for intraepithelial degenerative changes-necrosis, vacuole formation, inflammation, regeneration-mitosis, and subepithelial bulla formation. L levels were significantly higher in the L receiving groups. All histopathologic results were significantly worse in the RT group than in the none-RT groups. The L + RT and the L + RT + L groups had better results than the RT group. Grade 2-3 degenerative changes-necrosis and vacuole formation were significantly lesser in the L + RT and the L + RT + L groups than those in the RT group. There was a trend toward decreased subepithelial bulla formation and inflammation in the L + RT and the L + RT + L groups compared to the RT group. Regeneration-mitosis was insignificantly lesser in the L + RT and significantly fewer in the L + RT + L groups than that in the RT group.
authors.affiliation: a Faculty of Medicine, Department of Radiation Oncology , Cukurova University , Adana , Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Coskun
authors.affiliation: a Faculty of Medicine, Department of Radiation Oncology , Cukurova University , Adana , Turkey.
authors.forename: Fundagul
authors.initials: F
authors.lastname: Andic
authors.affiliation: b Experimental Medicine Research Center, Cukurova University , Adana , Turkey.
authors.forename: Yusuf Kenan
authors.initials: YK
authors.lastname: Daglıoglu
authors.affiliation: c Faculty of Medicine, Department of Pathology , Cukurova University , Adana , Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Doran
authors.affiliation: d Faculty of Veterinary Science, Department of Animal Nutrition , Firat University , Elazig , Turkey.
authors.forename: Kazım
authors.initials: K
authors.lastname: Sahin
authors.affiliation: a Faculty of Medicine, Department of Radiation Oncology , Cukurova University , Adana , Turkey.
authors.forename: Candas
authors.initials: C
authors.lastname: Tunalı
authors.affiliation: e Department of Medicine , Winship Cancer Institute of Emory University , Atlanta , Georgia , USA.
authors.forename: Omer
authors.initials: O
authors.lastname: Kucuk
mesh_terms: D000818:Animals; D002338:Carotenoids / Q000494:pharmacology*; D004941:Esophagitis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000077276:Lycopene; D011832:Radiation Injuries / Q000473:pathology / Q000517:prevention & control*; D011878:Radiotherapy / Q000009:adverse effects; D017208:Rats, Wistar
chemical_list: D002338:Carotenoids; D000077276:Lycopene