title: Regioselective magnesiation of N-heterocyclic molecules: securing insecure cyclic anions by a β-diketiminate-magnesium clamp.
abstract: Using a specially designed magnesium metallating manifold, combining kinetically activated TMP amide base with a sterically amplified β-diketiminate ligand, this study has established a new regioselective strategy for magnesiation of challenging N-heterocyclic molecules. The broad scope of the approach is illustrated through reactions of pyrazine, triazoles and substituted pyridines by isolation and structural elucidation of their magnesiated intermediates.
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Laia
authors.initials: L
authors.lastname: Davin
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Ross
authors.initials: R
authors.lastname: McLellan
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Alberto
authors.initials: A
authors.lastname: Hernán-Gómez
authors.affiliation: School of Chemistry, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: William
authors.initials: W
authors.lastname: Clegg
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Maria
authors.initials: M
authors.lastname: Mertens
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Iain A
authors.initials: IA
authors.lastname: Stepek
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK. eva.hevia@strath.ac.uk.
authors.forename: Eva
authors.identifier: http://orcid.org/0000-0002-3998-7506
authors.initials: E
authors.lastname: Hevia