title: Functional consequences of pre- and postsynaptic expression of synaptic plasticity.
abstract: Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
authors.affiliation: Institute for Adaptive and Neural Computation, School of Informatics University of Edinburgh, Edinburgh, UK.|Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.
authors.forename: Rui Ponte
authors.identifier: 0000-0003-2595-2027
authors.initials: RP
authors.lastname: Costa
authors.affiliation: Instituto de Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.|Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Program for Brain Repair and Integrative Neuroscience, The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
authors.forename: Beatriz E P
authors.initials: BE
authors.lastname: Mizusaki
authors.affiliation: Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Program for Brain Repair and Integrative Neuroscience, The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
authors.forename: P Jesper
authors.identifier: 0000-0001-7085-2223
authors.initials: PJ
authors.lastname: Sjöström
authors.affiliation: Institute for Adaptive and Neural Computation, School of Informatics University of Edinburgh, Edinburgh, UK mvanross@inf.ed.ac.uk.
authors.forename: Mark C W
authors.identifier: 0000-0001-6525-6814
authors.initials: MC
authors.lastname: van Rossum
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D008568:Memory; D008959:Models, Neurological; D009473:Neuronal Plasticity; D011930:Reaction Time; D012677:Sensation
keywords: Hebbian plasticity; homoeostatic plasticity; long-term potentiation; spike-timing-dependent plasticity; synaptic plasticity; synaptic release