title: Poly(A)-binding proteins are required for translational regulation in vertebrate oocytes and early embryos.
abstract: Poly(A)-binding proteins (PABPs) function in the timely regulation of gene expression during oocyte maturation, fertilisation and early embryo development in vertebrates. To this end, PABPs bind to poly(A) tails or specific sequences of maternally stored mRNAs to protect them from degradation and to promote their translational activities. To date, two structurally different PABP groups have been identified: (1) cytoplasmic PABPs, including poly(A)-binding protein, cytoplasmic 1 (PABPC1), embryonic poly(A)-binding protein (EPAB), induced PABP and poly(A)-binding protein, cytoplasmic 3; and (2) nuclear PABPs, namely embryonic poly(A)-binding protein 2 and nuclear poly(A)-binding protein 1. Many studies have been undertaken to characterise the spatial and temporal expression patterns and subcellular localisations of PABPC1 and EPAB in vertebrate oocytes and early embryos. In the present review, we comprehensively evaluate and discuss the expression patterns and particular functions of the EPAB and PABPC1 genes, especially in mouse and human oocytes and early embryos.
authors.affiliation: Department of Histology and Embryology, Akdeniz University, School of Medicine, Campus, 07070, Antalya, Turkey.
authors.forename: Saffet
authors.initials: S
authors.lastname: Ozturk
authors.affiliation: Department of Histology and Embryology, Akdeniz University, School of Medicine, Campus, 07070, Antalya, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Uysal
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D009865:Oocytes / Q000378:metabolism*; D009866:Oogenesis / Q000502:physiology*; D039102:Poly(A)-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D014714:Vertebrates
chemical_list: D039102:Poly(A)-Binding Proteins