title: Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2.
abstract: Aging is associated with a range of chronic low-grade inflammation (Chronoinflammaging) which may play a significant role in some chronic inflammatory based diseases, such as Alzheimer disease (AD). However, the events which lead to the induction of chronoinflammaging in AD are yet to be clarified. It has been proposed that the recognition of endogenous ligands by pathogen recognition receptors (PRRs) may be involved in the induction of chronoinflammaging. Toll like receptors (TLRs) are a family of PRRs which recognize endogenous damage associated molecular patterns (DAMPs) and subsequently induce inflammation. Therefore, TLRs are worthy of investigation to elucidate their roles in chronoinflammaging associated AD. This review article explores the main roles played by TLR2 in the pathogenesis of chronoinflammaging in patients suffering from AD.
authors.affiliation: Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Dept. of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ravari
authors.affiliation: Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Dept. of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address: Mirzaei_t@yahoo.com.
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Mirzaei
authors.affiliation: School of Natural Sciences, Eskitis Institute for Drug Discovery, Griffith University Nathan, Queensland, Australia.
authors.forename: Derek
authors.initials: D
authors.lastname: Kennedy
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Dept. of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kazemi Arababadi
mesh_terms: D000544:Alzheimer Disease / Q000150:complications*; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000150:complications*; D051195:Toll-Like Receptor 2 / Q000502:physiology*
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2
keywords: Aging; Alzheimer; Inflammation; TLR2