title: Serum and urinary thioredoxin concentrations are associated with severity of children hydronephrosis.
abstract: BACKGROUND
  Ureteropelvic junction obstruction (UPJO) is the most common cause of hydronephrosis in children. This study was to assess the relationship between serum thioredoxin (S-Trx) and urinary thioredoxin (U-Trx) concentrations and severity of children hydronephrosis caused by UPJO.
  
  
  METHODS
  This study included 156 hydronephrosis children with unilateral UPJO and 80 healthy children. S-Trx and U-Trx concentrations were measured using enzyme-linked immunosorbent assay. U-Trx/creatinine (cr) ratio was calculated.
  
  
  RESULTS
  S-Trx and U-Trx concentrations and U-Trx/cr ratio were significantly higher in hydronephrosis children than in healthy children. They were significantly correlated with split renal function, anterior-posterior diameter and Society for Fetal Urology classification, as well as were independently related to the split renal function <39.2%, anterior-posterior diameter>30mm and Society for Fetal Urology grade IV. Under receiver operating characteristic curves, U-Trx/cr ratio showed the higher predictive value compared to S-Trx and U-Trx concentrations.
  
  
  CONCLUSIONS
  Increased S-Trx and U-Trx concentrations, especially U-Trx/cr ratio, are closely associated with the severity of children hydronephrosis, substantializing Trx as a promising biomarker for the progression of children hydronephrosis.
authors.affiliation: Department of Urology, The Children's Hospital, College of Medicine, Zhejiang University, 57 Zhugan Lane, Hangzhou 310003, China.
authors.forename: Zhe-Ming
authors.initials: ZM
authors.lastname: Xu
authors.affiliation: Department of Urology, The Children's Hospital, College of Medicine, Zhejiang University, 57 Zhugan Lane, Hangzhou 310003, China.
authors.forename: Min-Ju
authors.initials: MJ
authors.lastname: Li
authors.affiliation: Department of Urology, The Children's Hospital, College of Medicine, Zhejiang University, 57 Zhugan Lane, Hangzhou 310003, China. Electronic address: hedonghege@163.com.
authors.forename: Chang
authors.initials: C
authors.lastname: Tao
mesh_terms: D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000032:analysis; D018450:Disease Progression; D006801:Humans; D006869:Hydronephrosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D012720:Severity of Illness Index; D013879:Thioredoxins / Q000032:analysis* / Q000097:blood / Q000652:urine; D014517:Ureteral Obstruction / Q000150:complications
chemical_list: D015415:Biomarkers; C491203:TXN protein, human; D013879:Thioredoxins; D003404:Creatinine
keywords: Children; Hydronephrosis; Thioredoxin; Ureteropelvic junction obstruction