title: Flow optimization in vascular networks.
abstract: The development of mathematical models for studying phenomena observed in vascular networks is very useful for its potential applications in medicine and physiology. Detailed 3D studies of flow in the arterial system based on the Navier-Stokes equations require high computational power, hence reduced models are often used, both for the constitutive laws and the spatial domain. In order to capture the major features of the phenomena under study, such as variations in arterial pressure and flow velocity, the resulting PDE models on networks require appropriate junction and boundary conditions. Instead of considering an entire network, we simulate portions of the latter and use inflow and outflow conditions which realistically mimic the behavior of the network that has not been included in the spatial domain. The resulting PDEs are solved numerically using a discontinuous Galerkin scheme for the spatial and Adam-Bashforth method for the temporal discretization. The aim is to study the effect of truncation to the flow in the root edge of a fractal network, the effect of adding or subtracting an edge to a given network, and optimal control strategies on a network in the event of a blockage or unblockage of an edge or of an entire subtree.
authors.affiliation: Department of Mathematics, University of Colorado Colorado Springs, Colorado Springs, CO 80919, United States. email: radu@uccs.edu.
authors.forename: Radu C
authors.initials: RC
authors.lastname: Cascaval
authors.forename: Ciro
authors.initials: C
authors.lastname: D'Apice
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: D'Arienzo
authors.forename: Rosanna
authors.initials: R
authors.lastname: Manzo
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D001808:Blood Vessels / Q000473:pathology / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular