title: Evaluation of a 24-gene signature for prognosis of metastatic events and prostate cancer-specific mortality.
abstract: To determine the prognostic potential of a 24-gene signature, Sig24, for identifying patients with prostate cancer who are at risk of developing metastases or of prostate cancer-specific mortality (PCSM) after radical prostatectomy (RP).
  
  
  
  Sig24 scores were calculated from previously collected gene expression microarray data from the Cleveland Clinic and Mayo Clinic (I and II). The performance of Sig24 was determined using time-dependent c-index analysis, Cox proportional hazards regression and Kaplan-Meier survival analysis.
  
  
  
  Higher Sig24 scores were significantly associated with higher pathological Gleason scores in all three cohorts. Analysis of the Mayo Clinic II cohort, which included time-to-event information, indicated that patients with high Sig24 scores also had a higher risk of developing metastasis (hazard ratio [HR] 3.78, 95% confidence interval [CI]: 1.96-7.29; P < 0.001) or of PCSM (HR 6.54, 95% CI: 2.16-19.83; P < 0.001).
  
  
  
  The findings of the present study show the applicability of Sig24 for the prognosis of metastasis or PCSM after RP. Future studies investigating the combination of Sig24 with available prognostic tests may provide new approaches to improve risk stratification for patients with prostate cancer.
authors.affiliation: Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.|Winship Cancer Institute, Atlanta, GA, USA.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Pellegrini
authors.affiliation: Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.|Winship Cancer Institute, Atlanta, GA, USA.
authors.forename: Martin G
authors.initials: MG
authors.lastname: Sanda
authors.affiliation: Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.|Winship Cancer Institute, Atlanta, GA, USA.
authors.forename: Dattatraya
authors.initials: D
authors.lastname: Patil
authors.affiliation: Winship Cancer Institute, Atlanta, GA, USA.|Department of Biostatistics and Epidemiology and Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.|Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Long
authors.affiliation: GenomeDx Biosciences, Vancouver, BC, Canada.
authors.forename: María
authors.initials: M
authors.lastname: Santiago-Jiménez
authors.affiliation: GenomeDx Biosciences, Vancouver, BC, Canada.
authors.forename: Mandeep
authors.initials: M
authors.lastname: Takhar
authors.affiliation: GenomeDx Biosciences, Vancouver, BC, Canada.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Erho
authors.affiliation: GenomeDx Biosciences, Vancouver, BC, Canada.
authors.forename: Kasra
authors.initials: K
authors.lastname: Yousefi
authors.affiliation: GenomeDx Biosciences, Vancouver, BC, Canada.
authors.forename: Elai
authors.initials: E
authors.lastname: Davicioni
authors.affiliation: Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Klein
authors.affiliation: Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Jenkins
authors.affiliation: Department of Urology, Mayo Clinic, Rochester, MN, USA.
authors.forename: R Jeffrey
authors.initials: RJ
authors.lastname: Karnes
authors.affiliation: Winship Cancer Institute, Atlanta, GA, USA.|Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.|Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Carlos S
authors.initials: CS
authors.lastname: Moreno
mesh_terms: D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D046228:Microarray Analysis; D009362:Neoplasm Metastasis; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D059467:Transcriptome
keywords: #PCSM; #ProstateCancer; biomarker; metastasis