title: Clinical variations in Parkinson's disease patients with or without REM sleep behaviour disorder: a meta-analysis.
abstract: This study aimed to evaluate the clinical variations in patients with Parkinson's disease (PD) with (PDRBD) or without REM sleep behaviour disorder (RBD) (Non-RBD), and PDRBD patients were classified into Confirmed-RBD (definite diagnosis with polysomnography, PSG) and Probable-RBD (without PSG re-confirmation). The clinical difference between the groups of patients was measured as an odds ratio (OR) or standardized mean difference (SMD, Cohen d). A total of 31 articles with data from 5,785 participants were obtained for our analysis. Overall, the occurrence of Confirmed-RBD was more frequent in male patients (OR = 1.25; p = 0.038), elderly patients (SMD = 0.25; p = 0.000), and patients with longer disease duration (SMD = 0.30; p = 0.000), increased Hoehn-Yahr scale (SMD = 0.30; p = 0.000), and higher UPDRS-III score (SMD = 0.38; p = 0.002). On the other hand, the frequency of Probable-RBD was increased with disease duration (SMD = 0.29; p = 0.000), Hoehn-Yahr scale (SMD = 0.30; p = 0.000), and UPDRS-III score (SMD = 0.26; p = 0.001). Our study indicate that PDRBD patients may have different clinical features compared to patients with Non-RBD.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.|Department of Medical Psychology, Anhui Medical University, Hefei, China.|Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.|Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Ruo-Lin
authors.initials: RL
authors.lastname: Zhu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.|Department of Medical Psychology, Anhui Medical University, Hefei, China.|Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.|Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Cheng-Juan
authors.initials: CJ
authors.lastname: Xie
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.|Department of Medical Psychology, Anhui Medical University, Hefei, China.|Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.|Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Hu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.|Department of Medical Psychology, Anhui Medical University, Hefei, China.|Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.|Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D000073537:Biological Variation, Population; D016022:Case-Control Studies; D006801:Humans; D016017:Odds Ratio; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis*; D017286:Polysomnography; D017594:Publication Bias; D020187:REM Sleep Behavior Disorder / Q000150:complications* / Q000175:diagnosis*