title: Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes.
abstract: A mild, general, and high yielding synthesis of N-acyl 2-aminobenzothiazoles has been demonstrated by N-heterocyclic carbene (NHC)-organocatalyzed direct amidation of aldehydes with 2-aminobenzothiazoles proceeding via acyl azolium intermediates. The carbene generated from the triazolium salt under oxidative conditions was the key for the success of this reaction. The method was subsequently applied to the synthesis of various biologically important N-acyl 2-aminobenzothiazoles.
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in y.santhivardhna@ncl.res.in.
authors.forename: Sethulekshmy
authors.initials: S
authors.lastname: Premaletha
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in y.santhivardhna@ncl.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi 110020, India.
authors.forename: Arghya
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in y.santhivardhna@ncl.res.in.
authors.forename: Sumi
authors.initials: S
authors.lastname: Joseph
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in y.santhivardhna@ncl.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi 110020, India.
authors.forename: Santhivardhana Reddy
authors.initials: SR
authors.lastname: Yetra
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in y.santhivardhna@ncl.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi 110020, India.
authors.forename: Akkattu T
authors.identifier: http://orcid.org/0000-0002-0645-8261
authors.initials: AT
authors.lastname: Biju