title: [Primary Tumor Resection in Incurable Stage IV Colorectal Cancer].
abstract: The influence of primary tumor resection on the prognosis of patients with incurable Stage IV colorectal cancer is unclear. We retrospectively analyzed 30 patients with incurable Stage IV colorectal cancer who underwent primary tumor resection. Postoperative complications occurred in 13 patients(43.3%)classified as grades greater than Clavien-Dindo classification II . There was no mortality. Median duration of hospital stay after surgery was 23 days. Fourteen patients(46.7%)underwent chemotherapy after surgery, of which 12 were administered molecular targeted therapy. The median number of chemotherapy regimens was 2(range, 1 to 3). The median time between start and end of chemotherapy was 11.8 months. The median survival time(MST)of all patients was 16.9 months. The MST of patients treated with chemotherapy combined with molecular targeted therapy(60.6 months)was significantly longer than those who did not undergo chemotherapy(10.9 months). Chemotherapy combined with molecular targeted therapy contributes to survival after primary tumor resection in patients with incurable Stage IV colorectal cancer.
authors.affiliation: Dept. of Surgery, Japan Community Health Care Organization, Yokohama Chuo Hospital.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mimatsu
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Kida
authors.forename: Nobutada
authors.initials: N
authors.lastname: Fukino
mesh_terms: D000368:Aged; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011183:Postoperative Complications; D012189:Retrospective Studies