title: [A Long-Surviving Case of Unresectable Gall Bladder Carcinoma Treated with Gemcitabine-Based Chemotherapy].
abstract: We report a 5-year surviving patient with unresectable gall bladder carcinoma treated with gemcitabine(GEM)-based chemotherapy. A 64-year-old man was diagnosed with unresectable gall bladder carcinoma with peritoneal dissemination based on laparotomy findings. Two months later, he started to receive GEM chemotherapy. Twelve months after surgery, the patient chose to suspend GEM treatment. One year and 10 months later, multiple lung metastases appeared and GEM was restarted in combination with UFT. Although the primary lesion and lung metastases gradually progressed, the patient maintained a good quality of life. After 3 years and 2 months, chemotherapy was changed to GEM plus S-1 because of progressive disease. Five years and 2 months after surgery, his condition was complicated by a secondary pneumothorax, and the patient received home oxygen therapy. Five years and 8 months after surgery he died of respiratory distress caused by the progression of lung metastases. Even in the case of unresectable advanced gall bladder carcinoma, effective chemotherapy could improve quality of life and prolong survival.
authors.affiliation: Dept. of Surgery, Hiroshima City Hiroshima Citizens Hospital.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Shiozaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Satoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Araki
authors.forename: Naoki
authors.initials: N
authors.lastname: Mimura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ogawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Idani
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Ojima
authors.forename: Masao
authors.initials: M
authors.lastname: Harano
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanazawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Choda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sumitani
authors.forename: Michihiro
authors.initials: M
authors.lastname: Ishida
authors.forename: Masazumi
authors.initials: M
authors.lastname: Okajima
authors.forename: Motoki
authors.initials: M
authors.lastname: Ninomiya
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D017809:Fatal Outcome; D005706:Gallbladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013997:Time Factors; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D000093542:Gemcitabine