title: Metabolomics in the Diagnosis and Pharmacotherapy of Lung Diseases.
abstract: Metabolomics is of the increasing interests in medical research and the study of respiratory diseases. This novel type of small molecule analysis can be performed not only on conventional biological samples such as plasma or urine but also on sputum, bronchoalveolar fluid, exhaled breath condensate or exhaled breath itself (which is particularly relevant for research on respiratory diseases). On one hand, powerful analytical methodologies (including mass spectrometry and nuclear magnetic resonance spectroscopy) are labour-intensive but enable the exhaustive identification of metabolites. On the other hand, electronic noses can be used for exhaled breath analysis. Although the latter devices do not contain metabolite-specific sensors, they produce a condition- or treatment-specific "breathprint" based on pattern recognition. Breath analysis with electronic noses is noninvasive, and can be performed at the bedside in real time. Here, we review the literature on metabolomics studies in respiratory medicine, with a focus on the evaluation of responses to pharmacotherapy.
authors.affiliation: UPRES EA220, Université Versailles Saint Quentin, Hôpital Foch, 11 rue Guillaume Lenoir, F-92150 Suresnes, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Devillier
authors.affiliation: UPRES EA220, Université Versailles Saint Quentin, Hôpital Foch, 11 rue Guillaume Lenoir, F-92150 Suresnes, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Salvator
authors.affiliation: UPRES EA220, Université Versailles Saint Quentin, Hôpital Foch, 11 rue Guillaume Lenoir, F-92150 Suresnes, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Naline
authors.affiliation: Département des Maladies des Voies Respiratoires, Hôpital Foch, Université Versailles Saint Quentin en Yvelines, Université Paris Saclay, F-92150 Suresnes, France.
authors.forename: Louis-Jean
authors.initials: LJ
authors.lastname: Couderc
authors.affiliation: INSERM UMR1173, UFR Sciences de la Santé Simone Veil, Université Versailles Saint Quentin en Yvelines, Université Paris Saclay, 2, avenue de la source de la Bièvre, F- 78180 Montigny-le-Bretonneux, France.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Grassin-Delyle
mesh_terms: D000818:Animals; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D055432:Metabolomics; D054852:Small Molecule Libraries / Q000627:therapeutic use*
chemical_list: D054852:Small Molecule Libraries
keywords: Metabolomics; electronic nose.; lung disease; volatolomics