title: PSMA Uptake in Mediastinal Sarcoidosis.
abstract: Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein which is frequently overexpressed on prostate cancer cells. Ga-PSMA PET/CT plays an increasing role in prostate cancer management. However, growing evidence suggests increased PSMA uptake in a variety of other malignant tumor entities and in some benign lesions. This report describes PSMA uptake in numerous thoracic lymph nodes in a patient with known mediastinal sarcoidosis. Knowledge and recognition of these possibilities are important to avoid scan misinterpretation.
authors.affiliation: From the *Department of Nuclear Medicine, and †Department of Radiology, University Hospital Brussel; and ‡∥Department of Nuclear Medicine, AZ Sint-Jan Brugge-Oostende, Belgium.
authors.forename: Philip Junior
authors.initials: PJ
authors.lastname: Ardies
authors.forename: Pieterjan
authors.initials: P
authors.lastname: Gykiere
authors.forename: Lode
authors.initials: L
authors.lastname: Goethals
authors.forename: Johan
authors.initials: J
authors.lastname: De Mey
authors.forename: Frank
authors.initials: F
authors.lastname: De Geeter
authors.forename: Hendrik
authors.initials: H
authors.lastname: Everaert
mesh_terms: D000369:Aged, 80 and over; D004492:Edetic Acid / Q000031:analogs & derivatives; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging*; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D012507:Sarcoidosis / Q000000981:diagnostic imaging*
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid