title: Effects by inhalation of abundant fragrances in indoor air - An overview.
abstract: Odorous compounds (odors) like fragrances may cause adverse health effects. To assess their importance by inhalation, we have reviewed how the four major abundant and common airborne fragrances (α-pinene (APN), limonene (LIM), linalool (LIL), and eugenol (EUG)) impact the perceived indoor air quality as odor annoyance, sensory irritation and sensitization in the airways. Breathing and cardiovascular effects, and work performance, and the impact in the airways of ozone-initiated gas- and particle phase reactions products have also been assessed. Measured maximum indoor concentrations for APN, LIM and LIL are close to or above their odor thresholds, but far below their thresholds for sensory irritation in the eyes and upper airways; no information could be traced for EUG. Likewise, reported risk values for long-term effects are far above reported indoor concentrations. Human exposure studies with mixtures of APN and LIM and supported by animal inhalation models do not support sensitization of the airways at indoor levels by inhalation that include other selected fragrances. Human exposure studies, in general, indicate that reported lung function effects are likely due to the perception rather than toxic effects of the fragrances. In general, effects on the breathing rate and mood by exposure to the fragrances are inconclusive. The fragrances may increase the high-frequency heart rate variability, but aerosol exposure during cleaning activities may result in a reduction. Distractive effects influencing the work performance by fragrance/odor exposure are consistently reported, but their persistence over time is unknown. Mice inhalation studies indicate that LIM or its reaction mixture may possess anti-inflammatory properties. There is insufficient information that ozone-initiated reactions with APN or LIM at typical indoor levels cause airway effects in humans. Limited experimental information is available on long-term effects of ozone-initiated reaction products of APN and LIM at typical indoor levels.
authors.affiliation: National Research Centre for the Working Environment, Copenhagen Ø, Denmark. Electronic address: pwo@nrcwe.dk.
authors.forename: Peder
authors.initials: P
authors.lastname: Wolkoff
authors.affiliation: National Research Centre for the Working Environment, Copenhagen Ø, Denmark.
authors.forename: Gunnar D
authors.initials: GD
authors.lastname: Nielsen
mesh_terms: D000080462:Acyclic Monoterpenes; D000393:Air Pollutants / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis*; D000818:Animals; D000081008:Bicyclic Monoterpenes; D053138:Cyclohexenes / Q000032:analysis / Q000494:pharmacology; D005054:Eugenol / Q000032:analysis / Q000494:pharmacology; D006801:Humans; D007509:Irritants / Q000032:analysis* / Q000494:pharmacology; D000077222:Limonene; D051379:Mice; D039821:Monoterpenes / Q000032:analysis / Q000494:pharmacology; D012137:Respiratory System / Q000187:drug effects*; D013729:Terpenes / Q000032:analysis / Q000494:pharmacology
chemical_list: D000080462:Acyclic Monoterpenes; D000393:Air Pollutants; D000081008:Bicyclic Monoterpenes; D053138:Cyclohexenes; D007509:Irritants; D039821:Monoterpenes; D013729:Terpenes; D005054:Eugenol; D000077222:Limonene; C018584:linalool; C005451:alpha-pinene
keywords: Airway effects; Fragrances; Lung functions; Odor; Sensory irritation; Terpenes