title: [Prevalence and extent of coronary artery calcification in an asymptomatic cardiovascular Mexican population: Genetics of Atherosclerotic Disease study].
abstract: OBJECTIVE
  The prevalence of coronary artery calcification (CAC), a specific marker of atherosclerosis, is unknown in Mexico. Our aim was to investigate the prevalence and quantity of CAC and their association with cardiovascular risk factors in a Mexican population.
  
  
  METHODS
  CAC was measured by multidetector computed tomography in asymptomatic subjects who participated in the Genetics of Atherosclerotic Disease study. Cardiovascular risk factors and medication were recorded.
  
  
  RESULTS
  The sample included 1,423 individuals (49.5% men), aged 53.7±8.4 years. Those with CAC showed a higher prevalence of dyslipidaemia, diabetes, hypertension, and other risk factors. The prevalence of CAC>0 Agatston units was significantly higher among men (40%) than among women (13%). Mean values of CAC score increased consistently with increasing age and were higher in men than women in each age group. Age and high low density lipoprotein cholesterol were independently associated with prevalence of CAC>0 in men and women, while increasing systolic blood pressure in women and age in both genders showed an independent association with CAC extension.
  
  
  CONCLUSIONS
  In the Mexican population the prevalence and extent of CAC were much higher in men than in women, and strongly increased with age. Independent predictors of CAC prevalence were age and low density lipoprotein cholesterol (LDL-C).
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México. Electronic address: cposadasr@yahoo.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Fabiola
authors.initials: F
authors.lastname: López-Bautista
authors.affiliation: Departamento de Cardiología, Hospital General San Juan de Dios, Ciudad de Guatemala, Guatemala.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Rodas-Díaz
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.affiliation: Departamento de Tomografía, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Eric
authors.initials: E
authors.lastname: Kimura-Hayama
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Juan G
authors.initials: JG
authors.lastname: Juárez-Rojas
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Aida X
authors.initials: AX
authors.lastname: Medina-Urrutia
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Guillermo C
authors.initials: GC
authors.lastname: Cardoso-Saldaña
authors.affiliation: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Esteban
authors.initials: E
authors.lastname: Jorge-Galarza
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D002318:Cardiovascular Diseases / Q000150:complications; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D061205:Vascular Calcification / Q000453:epidemiology* / Q000209:etiology
keywords: Calcificación arterial coronaria; Coronary artery calcification; Estudio GEA; GEA study; Mexico; México; Prevalence; Prevalencia