title: Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III.
abstract: RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.
authors.affiliation: Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea.|Department of Functional Genomics, University of Science & Technology, Daejeon 305-806, Korea.
authors.forename: Jong-Lyul
authors.initials: JL
authors.lastname: Park
authors.affiliation: Cancer Genomics Branch, Research Institute, National Cancer Center, Goyang 10408, Korea.
authors.forename: Yeon-Su
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1072, USA.|Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
authors.forename: Nawapol
authors.initials: N
authors.lastname: Kunkeaw
authors.affiliation: Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea.|Department of Functional Genomics, University of Science & Technology, Daejeon 305-806, Korea.
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Graduate School of Cancer Science & Policy, National Cancer Center, Goyang 10408, Korea.
authors.forename: In-Hoo
authors.initials: IH
authors.lastname: Kim
authors.affiliation: Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1072, USA.|Graduate School of Cancer Science & Policy, National Cancer Center, Goyang 10408, Korea.
authors.forename: Yong Sun
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D006801:Humans; D012320:RNA Polymerase III / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D022661:RNA, Untranslated; D012320:RNA Polymerase III
keywords: RNA polymerase III; epigenetic regulation; nc886