title: Protein biomarker druggability profiling.
abstract: Developing automated and interactive methods for building a model by incorporating mechanistic and potentially causal annotations of ranked biomarkers of a disease or clinical condition followed by a mapping into a contextual framework in disease-linked biochemical pathways can be used for potential drug-target evaluation and for proposing new drug targets. We demonstrate the potential of this approach using ranked protein biomarkers obtained in neonatal sepsis by enrolling 127 infants (39 infants with late onset neonatal sepsis and 88 control infants) and by performing a focused proteomic profile of the sera and by applying the interactive druggability profiling algorithm (DPA) developed by us.
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Electronic address: manis@salud.unm.edu.
authors.forename: Subramani
authors.initials: S
authors.lastname: Mani
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Electronic address: cannon.danielc@gmail.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cannon
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Electronic address: rohls@salud.unm.edu.
authors.forename: Robin
authors.initials: R
authors.lastname: Ohls
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Electronic address: toprea@salud.unm.edu.
authors.forename: Tudor
authors.initials: T
authors.lastname: Oprea
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Electronic address: smathias@salud.unm.edu.
authors.forename: Stephen
authors.initials: S
authors.lastname: Mathias
authors.affiliation: Myriad RBM, Austin, TX 78759, United States. Electronic address: kballard@myriadrbm.com.
authors.forename: Karri
authors.initials: K
authors.lastname: Ballard
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Electronic address: oursu@salud.unm.edu.
authors.forename: Oleg
authors.initials: O
authors.lastname: Ursu
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Electronic address: cbologa@salud.unm.edu.
authors.forename: Cristian
authors.initials: C
authors.lastname: Bologa
mesh_terms: D000465:Algorithms; D015415:Biomarkers; D006801:Humans; D007231:Infant, Newborn; D000071074:Neonatal Sepsis / Q000175:diagnosis / Q000188:drug therapy; D040901:Proteomics
chemical_list: D015415:Biomarkers
keywords: Druggability profiling; Machine learning; Mechanistic annotation; Neonatal sepsis; Pathway analysis; Protein biomarkers