title: [Central sleep apnoea syndrome].
abstract: In central sleep apnoea syndrome (SAS), there is a dysfunction in central ventilatory command. Patients with central SAS can exhibit symptoms and complications linked to unstable sleep caused by apnoea and certain specific mechanisms (chronic and intermittent hypoxia). Central SAS is linked to several diseases which should be investigated before treatment. Treatment depends on underlying conditions and should focus on alleviating symptoms. Possible treatments include nocturnal non invasive ventilation and/or oxygen, and oral medications. Chronic heart failure with LVEF<45% is a contraindication to servo-assisted ventilation. Several observational French studies are currently enrolling patients to gain knowledge on disease and the impact of treatment.
authors.affiliation: Assistance publique Hôpitaux de Paris, hôpital Bichat, DHU FIRE, service de physiologie-explorations fonctionnelles, 75018 Paris, France; Université Denis-Diderot Paris 7, UFR de médecine, 75018 Paris, France.
authors.forename: Justine
authors.initials: J
authors.lastname: Frija-Masson
authors.affiliation: Assistance publique Hôpitaux de Paris, hôpital Bichat, DHU FIRE, service de physiologie-explorations fonctionnelles, 75018 Paris, France; Université Denis-Diderot Paris 7, UFR de médecine, 75018 Paris, France.
authors.forename: Ruben
authors.initials: R
authors.lastname: Wanono
authors.affiliation: Assistance publique Hôpitaux de Paris, hôpital Bichat, DHU FIRE, service de physiologie-explorations fonctionnelles, 75018 Paris, France; Université Denis-Diderot Paris 7, UFR de médecine, 75018 Paris, France; Assistance publique Hôpitaux de Paris, hôpital Robert-Debré, unité Inserm U1141, 75020 Paris, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Robinot
authors.affiliation: Assistance publique Hôpitaux de Paris, hôpital Bichat, DHU FIRE, service de physiologie-explorations fonctionnelles, 75018 Paris, France; Université Denis-Diderot Paris 7, UFR de médecine, 75018 Paris, France; Assistance publique Hôpitaux de Paris, hôpital Robert-Debré, unité Inserm U1141, 75020 Paris, France. Electronic address: marie-pia.dortho@aphp.fr.
authors.forename: Marie-Pia
authors.initials: MP
authors.lastname: d'Ortho
mesh_terms: D001993:Bronchodilator Agents / Q000627:therapeutic use; D054143:Heart Failure, Systolic / Q000150:complications; D006801:Humans; D063087:Noninvasive Ventilation; D010102:Oxygen Inhalation Therapy; D015995:Prevalence; D020182:Sleep Apnea, Central / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*
chemical_list: D001993:Bronchodilator Agents