title: [Impact of Drugs on Glaucoma and Intraocular Pressure].
abstract: PurposeSystemic drugs may have unfavourable effects on intraocular pressure, glaucoma and the efficacy of glaucoma drugs.Material and MethodsThe article provides a review of the literature from PubMed and clinical experience.ResultsTopical and systemic corticosteroids induce complex changes inside the trabecular meshwork. New genetic results improve the understanding of pathogenetic processes, although many questions are still open. Arterial hypertension and antihypertonic drugs may influence the risk of glaucoma, intraocular pressure and ocular perfusion pressure. Intravitreal anti-VEGF therapy may be associated with the risk of sustained intraocular pressure elevation. Systemic drugs with parasympaticolytic activity (e.g. psychopharmaceuticals) are able to induce acute angle block glaucoma.ConclusionNew insights into the interactions between drugs (e.g. antihypertensives, corticosteroids) and glaucomatous optic neuropathy affect large patient groups and may improve understanding of the underlying pathogenetic processes in open angle glaucoma. There is a great need for further clinical and experimental research.
authors.affiliation: Augenheilkunde, Tagesklinik Ambimed, Basel, Schweiz.
authors.forename: T
authors.initials: T
authors.lastname: Schlote
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D005901:Glaucoma / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D010276:Parasympatholytics / Q000009:adverse effects*; D018570:Risk Assessment; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D000305:Adrenal Cortex Hormones; D020533:Angiogenesis Inhibitors; D000959:Antihypertensive Agents; D010276:Parasympatholytics; D042461:Vascular Endothelial Growth Factor A