title: Neisseria meningitidis serogroup C sepsis and septic arthritis in an HIV-positive man.
abstract: A patient with well-controlled HIV-1 infection presented with fever and rigors, a widespread maculopapular rash, and severe generalised arthralgia. Sepsis of unknown aetiology was diagnosed, and treatment with broad-spectrum antimicrobials commenced. Following initial clinical improvement, a right knee septic arthritis developed. Microscopy and culture of the joint aspirate were negative for organisms but 16S rDNA PCR identified Neisseria meningitidis DNA, subsequently verified as capsular genogroup C, thus confirming a diagnosis of disseminated meningococcal sepsis with secondary septic arthritis.
authors.affiliation: 1 T8 Ward, University College London Hospitals NHS Foundation Trust, London, UK.|2 Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Fox-Lewis
authors.affiliation: 1 T8 Ward, University College London Hospitals NHS Foundation Trust, London, UK.|2 Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, UK.
authors.forename: C P
authors.initials: CP
authors.lastname: Eades
authors.affiliation: 1 T8 Ward, University College London Hospitals NHS Foundation Trust, London, UK.|3 Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: Manson
authors.affiliation: 4 Department of Clinical Microbiology, University College London Hospitals NHS Foundation Trust, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Morris-Jones
authors.affiliation: 1 T8 Ward, University College London Hospitals NHS Foundation Trust, London, UK.|2 Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, UK.|5 Research Department of Infection and Population Health, University College London, London, UK.|6 Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: R F
authors.initials: RF
authors.lastname: Miller
mesh_terms: D061605:Administration, Intravenous; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D005076:Exanthema; D005334:Fever; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D000077731:Meropenem; D008875:Middle Aged; D038542:Neisseria meningitidis, Serogroup C / Q000302:isolation & purification* / Q000472:pathogenicity; D016133:Polymerase Chain Reaction; D018805:Sepsis / Q000150:complications; D013845:Thienamycins / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077731:Meropenem
keywords: 16S rDNA; HIV; Neisseria meningitidis; septic arthritis