title: [A Study of Gemctabine plus Nab-Paclitaxel Therapy for Advanced Local Progressive Pancreatic Cancer].
abstract: We studied the significance of gemcitabine plus nab-paclitaxel(GnP)therapy for locally progressive pancreatic cancer. We enrolled 10 patients with local progression without distant metastasis. We used GnP therapy for the ablative borderline resectable(BR)and unresectable(UR)cases based on images that followed NCCN pancreatic cancer treatment guidelines. In 1 case of resectable(R)pancreatic cancer, the tumor was located in the pancreas body but we determined that surgery was impossible because of the underlying disease detected on imaging analysis. The 10 cases involved R(n=1), UR(n=5), and BR(n=4). Treatment toxicities were reported in all cases. We withheld treatment in the R case because of toxicities. The objective response rate was 40%, and the tumor control rate was 70% with CR 0, PR 4, SD 3, and PD 2. Resection was possible in 5 cases. The response rate to the GnP therapy was 40%, with a tumor control rate of 70%, allowing excision of 50%. We believe GnP therapy is feasible for operative resistant cases.
authors.affiliation: Dept. of Digestive and Breast Surgery, National Hospital Organization Disaster Medical Center.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Itoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saito
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Suematsu
authors.forename: Miyuki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Mao
authors.initials: M
authors.lastname: Nakayama
authors.forename: Michiko
authors.initials: M
authors.lastname: Fukabori
authors.forename: Akihiko
authors.initials: A
authors.lastname: Morita
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Wakabayashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D003841:Deoxycytidine; D017239:Paclitaxel; D000093542:Gemcitabine