title: Preliminary experimental study on splenic hemodynamics of radiofrequency ablation for the spleen.
abstract: OBJECTIVE
  To test the splenic blood flow change after radiofrequency ablation (RFA) of the spleen in a porcine experimental model.
  
  
  METHODS
  Six pigs underwent RFA of the spleen via laparotomy. During the procedure of RFA, clamping of splenic artery (one) and both splenic artery/vein (one) was also performed. Measurement of blood flow of both splenic artery (SA) and splenic vein (SV) with flow-wire at pre- and post-RFA of the spleen was also performed.
  
  
  RESULTS
  Ablated splenic lesions were created as estimating ∼50% area of the spleen in all pigs. Resected specimens reveal not only the coagulated necrosis but also the congestion of the spleen. On the SA hemodynamics, maximum peak velocity (MPV) changed from 37 ± 7 to 24 ± 8 cm/s (normal), 11 to 10 cm/s (clamp of the SA), and 12 to 7.5 cm/s (clamp of both SA/SV), respectively. On the SV hemodynamic, MPV changed from 15 ± 5 to 13 ± 4 cm/s (normal), 17 to 15 cm/s (clamp of the SA), and 17 to 26 cm/s (clamp of both SA/SV), respectively.
  
  
  CONCLUSIONS
  RFA of the spleen could induce coagulation necrosis and reduce the splenic arterial blood flow.
authors.affiliation: a Department of Radiology , Kagoshima University , Kagoshima , Japan.|c Department of Diagnostic Radiology , Hiroshima University , Hiroshima , Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Baba
authors.affiliation: a Department of Radiology , Kagoshima University , Kagoshima , Japan.
authors.forename: Sadao
authors.initials: S
authors.lastname: Hayashi
authors.affiliation: a Department of Radiology , Kagoshima University , Kagoshima , Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Nagasato
authors.affiliation: b Department of Human Pathology , Kagoshima University , Kagoshima , Japan.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Higashi
authors.affiliation: a Department of Radiology , Kagoshima University , Kagoshima , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000009:adverse effects* / Q000379:methods; D006439:Hemodynamics; D013154:Spleen / Q000098:blood supply / Q000601:surgery*; D013157:Splenic Artery / Q000503:physiopathology*; D013162:Splenic Vein / Q000503:physiopathology*; D013552:Swine
keywords: Portal hypertension; hypersplenism; radiofrequency ablation