title: NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils.
abstract: Neutrophil extracellular traps (NETs) were initially described as an antimicrobial mechanism of neutrophils. Over the last decade, several lines of evidence support the involvement of NETs in a plethora of pathological conditions. Clinical and experimental data indicate that NET release constitutes a shared mechanism, which is involved in a different degree in various manifestations of non-infectious diseases. Even though the backbone of NETs is similar, there are differences in their protein load in different diseases, which represent alterations in neutrophil protein expression in distinct disorder-specific microenvironments. The characterization of NET protein load in different NET-driven disorders could be of significant diagnostic and/or therapeutic value. Additionally, it will provide further evidence for the role of NETs in disease pathogenesis, and it will enable the characterization of disorders in which neutrophils and NET-dependent inflammation are of critical importance.
authors.affiliation: Laboratory of Molecular Hematology, Democritus University of Thrace , Alexandroupolis , Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Mitsios
authors.affiliation: Laboratory of Molecular Hematology, Democritus University of Thrace , Alexandroupolis , Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Arampatzioglou
authors.affiliation: Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece; Department of Pathology, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: Stella
authors.initials: S
authors.lastname: Arelaki
authors.affiliation: Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine Technische Universität Dresden , Dresden , Germany.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mitroulis
authors.affiliation: Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece; First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Ritis
keywords: autoimmunity; autoinflammation; neutrophil; neutrophil extracellular traps; thromboinflammation