title: [Two Cases of Advanced Gastric Cancer in the Upper Portion of the Stomach with Laparoscopic Total Gastrectomy after Neoadjuvant Chemotherapy].
abstract: Case 1: A 55-year-old woman was diagnosed with type 3 gastric cancer(U, post, 30 mm, por, cT4aN2M0)of cStage III B. She received 3 courses of a DOS regimen, which consisted of docetaxel, oxaliplatin, and S-1, as neoadjuvant chemotherapy (NAC). She subsequently underwent curative laparoscopic total gastrectomy with D2+No.16a2lat dissection, and resection of part of the right crus of the diaphragm, which was suspected to have cancer infiltration. S-1 was started as adjuvant chemotherapy 37 days after gastrectomy. The patient is alive without recurrence 6 months after surgery. Case 2: A 59-yearold man was diagnosed with type 3 gastric cancer(UM-E, less, 80 mm, por, cT4aN2M0)cStage III B. NACwith DOS was administered. After 3 courses of NACwere completed, we performed spleen-preserving curative laparoscopic total gastrectomy with D2+No.16a2lat dissection. S-1 was started as adjuvant chemotherapy 54 days after gastrectomy. The patient is alive without recurrence 6 months after surgery.
authors.affiliation: Dept. of Gastroenterological Surgery, Graduate School of Medicine, Osaka University.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Odagiri
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Shuji
authors.initials: S
authors.lastname: Takiguchi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Makino
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Kurokawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Nakajima
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
mesh_terms: D005260:Female; D005743:Gastrectomy; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome