title: Ara h 6 sensitization in peanut allergy: friend, foe or innocent bystander?
abstract: The clinical role of Ara h 6 sensitization in peanut allergy is a current matter of debate. We investigated the role of Ara h 6 sensitization patterns in a sample of young adults from different Italian cities. Sera of 33 patients with specific IgE against Ara h 6 were selected. According to clinical symptoms upon peanut ingestion, patients were divided into severe reaction (SR) and mild-tolerant (MT) subgroups. While the SR group mainly showed sensitization patterns involving Ara h 2 and other major allergenic components, a previously undescribed association between Ara h 6 and Ara h 9 was found in the MT group. This pattern seems to be clustered in Mediterranean Italy and associated with Pru p 3 sensitization. This finding might shed a new light on the role of Ara h 6 sensitization in peanut allergy.
authors.affiliation: Dipartimento di Medicina Interna, U.O. Allergologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti Ancona, Ancona, Italy. Phone: +39 071 596 5693 E-mail: c.tontini@live.com.
authors.forename: C
authors.initials: C
authors.lastname: Tontini
authors.affiliation: Dipartimento di Medicina Interna, U.O. Allergologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti Ancona, Ancona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Marinangeli
authors.affiliation: Dipartimento della Donna, del Bambino, Chirurgia Generale e Specialistica, Seconda Università di Napoli, Napoli, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Maiello
authors.affiliation: Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università di Napoli, Napoli, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Abbadessa
authors.affiliation: Allergologia ed Immunologia Clinica, Azienda Ospedaliera Santa Maria degli Angeli, Pordenone, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Villalta
authors.affiliation: Dipartimento di Medicina Interna, U.O. Allergologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti Ancona, Ancona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Antonicelli
mesh_terms: D055516:2S Albumins, Plant / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D052179:Antigens, Plant / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D021183:Peanut Hypersensitivity / Q000209:etiology*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D055516:2S Albumins, Plant; D052179:Antigens, Plant; C492737:Ara h 6 allergen, Arachis hypogaea
keywords: Ara h 2; Ara h 6; Ara h 9; component resolved diagnostic; peanut allergy