title: Optimal diagnostic thresholds for diagnosis of orthostatic hypotension with a 'sit-to-stand test'.
abstract: This study aimed to identify optimal blood pressure cut-offs to diagnose orthostatic hypotension during a sit-to-stand manoeuvre.
  
  
  
  This was a cross-sectional study of patients and healthy controls from the Vanderbilt Autonomic Dysfunction Center. Blood pressure was measured while supine, seated and standing. Blood pressure changes were calculated from supine-to-standing and seated-to-standing. Orthostatic hypotension was diagnosed on the basis of a supine-to-standing SBP drop at least 20 mmHg or a DBP drop at least 10 mmHg. Receiver operator characteristic (ROC) curves identified optimal sit-to-stand cut-offs.
  
  
  
  Amongst the 831 individuals, more had systolic orthostatic hypotension [n = 354 (43%)] than diastolic orthostatic hypotension [n = 305 (37%)] during lying-to-standing. The ROC curves had good characteristics [SBP area under curve = 0.916 (95% confidence interval: 0.896-0.936), P < 0.001; DBP area under curve = 0.930 (95% confidence interval: 0.909-0.950), P < 0.001]. A sit-to stand SBP drop at least 15 mmHg had optimal test characteristics (sensitivity = 80.2%; specificity = 88.9%; positive predictive value = 84.2%; negative predictive value = 85.8%), as did a DBP drop at least 7 mmHg (sensitivity = 87.2%; specificity = 87.2%; positive predictive value = 80.1%; negative predictive value = 92.0%).
  
  
  
  A sit-to-stand manoeuvre with lower diagnostic cut-offs for orthostatic hypotension provides a simple screening test for orthostatic hypotension in situations wherein a supine-to-standing manoeuvre cannot be easily performed. Our analysis suggests that a SBP drop at least 15 mmHg or a DBP drop at least 7 mmHg best optimizes sensitivity and specificity of this sit-to-stand test.
authors.affiliation: aDepartment of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada bAutonomic Dysfunction Center, Division of Clinical Pharmacology cDepartment of Medicine dDepartment of Biomedical Engineering eDepartment of Biostatistics fDepartment of Pharmacology gDepartment of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Brett H
authors.initials: BH
authors.lastname: Shaw
authors.forename: Emily M
authors.initials: EM
authors.lastname: Garland
authors.forename: Bonnie K
authors.initials: BK
authors.lastname: Black
authors.forename: Sachin Y
authors.initials: SY
authors.lastname: Paranjape
authors.forename: Cyndya A
authors.initials: CA
authors.lastname: Shibao
authors.forename: Luis E
authors.initials: LE
authors.lastname: Okamoto
authors.forename: Alfredo
authors.initials: A
authors.lastname: Gamboa
authors.forename: André
authors.initials: A
authors.lastname: Diedrich
authors.forename: W Dale
authors.initials: WD
authors.lastname: Plummer
authors.forename: William D
authors.initials: WD
authors.lastname: Dupont
authors.forename: Italo
authors.initials: I
authors.lastname: Biaggioni
authors.forename: David
authors.initials: D
authors.lastname: Robertson
authors.forename: Satish R
authors.initials: SR
authors.lastname: Raj
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001794:Blood Pressure; D001795:Blood Pressure Determination; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003971:Diastole; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis* / Q000503:physiopathology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D013599:Systole; D055815:Young Adult