title: Multimodality functional imaging using DW-MRI and18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience.
abstract: OBJECTIVE
  To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging (DW-MRI) and glucose metabolism measured by18F-labeled fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) during radiation therapy (RT) for human papillomavirus negative (HPV-) head and neck squamous cell carcinoma (HNSCC).
  
  
  METHODS
  In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations DW-MRI at 1.5 T Philips MRI scanner [(n= 24) pre-, during- (2-3 wk), and post-treatment (Tx), and18F-FDG PET/CT pre- and post-Tx (n= 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient (ADC) and the mean of standardized uptake value (SUV) was measured from18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.
  
  
  RESULTS
  There was a strong negative correlation between the mean of pretreatment ADC (ρ = -0.67,P= 0.01) and the pretreatment18F-FDG PET SUV. The percentage (%) change in delta (∆) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.
  
  
  CONCLUSIONS
  These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience.
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Aramburu Núñez
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez Medina
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Moisés
authors.initials: M
authors.lastname: Mera Iglesias
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Salvador Gomez
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Abhay
authors.initials: A
authors.lastname: Dave
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Vaios
authors.initials: V
authors.lastname: Hatzoglou
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Paudyal
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Calzado
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Deasy
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Amita
authors.initials: A
authors.lastname: Shukla-Dave
authors.affiliation: David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Muñoz
keywords: 18F-labeled fluorodeoxyglucose positron emission tomography/computed tomography; Diffusion-weighted magnetic resonance imaging; Human papillomavirus negative head and neck squamous cell carcinoma