title: Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining.
abstract: Quorum sensing plays a pivotal role in Pseudomonas aeruginosa's virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databases was used to create a knowledge network of potential anti-quorum sensing agents for P. aeruginosa. A total of 110 scientific articles, corresponding to 1,004 annotations, were so far included in the network and are analysed in this work. Information on the most studied agents, QS targets and methods is detailed. This knowledge network offers a unique view of existing strategies for quorum sensing inhibition and their main regulatory targets and may be used to readily access otherwise scattered information and to help generate new testable hypotheses. This knowledge network is publicly available at http://pcquorum.org/ .
authors.affiliation: a ESEI - Escuela Superior de Ingeniería Informática , Universidad de Vigo , Ourense , Spain.
authors.forename: Martín
authors.initials: M
authors.lastname: Pérez-Pérez
authors.affiliation: b CEB - Centre of Biological Engineering, LIBRO - Laboratory of Research in Biofilms Rosário Oliveira , University of Minho , Braga , Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: Jorge
authors.affiliation: a ESEI - Escuela Superior de Ingeniería Informática , Universidad de Vigo , Ourense , Spain.
authors.forename: Gael
authors.initials: G
authors.lastname: Pérez Rodríguez
authors.affiliation: b CEB - Centre of Biological Engineering, LIBRO - Laboratory of Research in Biofilms Rosário Oliveira , University of Minho , Braga , Portugal.
authors.forename: Maria Olívia
authors.initials: MO
authors.lastname: Pereira
authors.affiliation: a ESEI - Escuela Superior de Ingeniería Informática , Universidad de Vigo , Ourense , Spain.|c CEB - Centre of Biological Engineering , University of Minho , Braga , Portugal.
authors.forename: Anália
authors.initials: A
authors.lastname: Lourenço
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D019295:Computational Biology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology; D053038:Quorum Sensing / Q000187:drug effects*; D014774:Virulence / Q000187:drug effects*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors
keywords: Pseudomonas aeruginosa; Quorum-sensing; biofilm; bioinformatics; networks; quorum-quenching