title: [A Case of Advanced Rectal Cancer Resulting in a Pathologically Complete Response after Neoadjuvant Chemotherapy].
abstract: A 61-years-old man was admitted to our hospital because of abdominal pain. Colonoscopy revealed a type 2 tumor in the rectum, which was diagnosed as low differentiated adenocarcinoma. At least 8 abdominal lymph adenopathies were enhanced on contrast-enhanced CT. We diagnosed stage cT3N2H0M0P0, cStage III b. Because of the risk of a poor prognosis, we tried neoadjuvant chemotherapy for the purpose of down staging. A CRT was prevented by Clostridium difficile enteritis, but we completed 80% of the regimen. Laparoscopic abdominoperineal resection was performed after 4 months of chemotherapy. The specimen contained no tumor lesion, and the pathology results were no residue of adenocarcinoma, status postchemoradiation therapy, Grade 3.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Minoji
authors.forename: Kohei
authors.initials: K
authors.lastname: Murata
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kitahara
authors.forename: Shu
authors.initials: S
authors.lastname: Okamura
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Nushijima
authors.forename: Rie
authors.initials: R
authors.lastname: Hamano
authors.forename: Tetsu
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Nariaki
authors.initials: N
authors.lastname: Fukuchi
authors.forename: Chikara
authors.initials: C
authors.lastname: Ebisui
authors.forename: Hideoki
authors.initials: H
authors.lastname: Yokouchi
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Kinuta
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ohishi
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000069287:Capecitabine; D059248:Chemoradiotherapy; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005472:Fluorouracil / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010071:Oxaloacetates; D012004:Rectal Neoplasms / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil