title: Fabrication and characterization of shape memory polymers based bioabsorbable biomedical drug eluting stent.
abstract: Present investigation deals with, tacrolimus eluting, self-expandable, biodegradable stent fabricated by solvent casting method. The design was based on shape memory polymers, which possess the ability to memorize temporary shape that can substantially differ from their initial permanent shape. A set of biodegradable polymers blend was used such as poly-lactic acid (PLA) and poly-l-glycolic acid (PLGA) to study the shape memory effect of polymer. The prepared stent was assessed for various parameters like Scanning Electron Microscopy (SEM), In-vitro and Ex vivo expansion, Drug content, In-vitro drug release, Haemocompatibility, Differential Scanning Calorimetry (DSC), Fourier Transform Infrared spectroscopy (FTIR), and Textural Characterization.
authors.affiliation: a Post Graduate Department of Pharmaceutics , H R Patel Institute of Pharmaceutical Education and Research , Shirpur , Maharashtra , India.
authors.forename: Vratika C
authors.initials: VC
authors.lastname: Sonawane
authors.affiliation: a Post Graduate Department of Pharmaceutics , H R Patel Institute of Pharmaceutical Education and Research , Shirpur , Maharashtra , India.
authors.forename: Mahesh P
authors.initials: MP
authors.lastname: More
authors.affiliation: a Post Graduate Department of Pharmaceutics , H R Patel Institute of Pharmaceutical Education and Research , Shirpur , Maharashtra , India.
authors.forename: Abhijeet P
authors.initials: AP
authors.lastname: Pandey
authors.affiliation: b Department of Pharmaceutical Chemistry , H R Patel Institute of Pharmaceutical Education and Research , Shirpur , Maharashtra , India.
authors.forename: Pravin O
authors.initials: PO
authors.lastname: Patil
authors.affiliation: a Post Graduate Department of Pharmaceutics , H R Patel Institute of Pharmaceutical Education and Research , Shirpur , Maharashtra , India.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Deshmukh
mesh_terms: D065966:Absorption, Physicochemical; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D054855:Drug-Eluting Stents; D006041:Goats; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D055595:Mechanical Phenomena; D010973:Platelet Adhesiveness / Q000187:drug effects; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers
keywords: Stent; bioabsorbable; biodegradable; self-expandable; shape-memory polymer