title: American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.
abstract: American Thyroid Association (ATA) leadership asked the ATA Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Task Force to review, comment on, and make recommendations related to the suggested new classification of encapsulated follicular variant papillary thyroid carcinoma (eFVPTC) without capsular or vascular invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The task force consists of members from the 2015 guidelines task force with the recusal of three members who were authors on the paper under review. Four pathologists and one endocrinologist were added for this specific review. The manuscript proposing the new classification and related literature were assessed. It is recommended that the histopathologic nomenclature for eFVPTC without invasion be reclassified as a NIFTP, given the excellent prognosis of this neoplastic variant. This is a weak recommendation based on moderate-quality evidence. It is also noted that prospective studies are needed to validate the observed patient outcomes (and test performance in predicting thyroid cancer outcomes), as well as implications on patients' psychosocial health and economics.
authors.affiliation: 1 University of Colorado School of Medicine , Aurora, Colorado.
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Haugen
authors.affiliation: 2 University Health Network, University of Toronto , Toronto, Canada .
authors.forename: Anna M
authors.initials: AM
authors.lastname: Sawka
authors.affiliation: 3 Brigham and Women's Hospital , Harvard Medical School, Boston, Massachusetts.
authors.forename: Erik K
authors.initials: EK
authors.lastname: Alexander
authors.affiliation: 4 The Mayo Clinic , Rochester, Minnesota.
authors.forename: Keith C
authors.initials: KC
authors.lastname: Bible
authors.affiliation: 5 Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Patrizio
authors.initials: P
authors.lastname: Caturegli
authors.affiliation: 6 Boston Medical Center , Boston, Massachusetts.
authors.forename: Gerard M
authors.initials: GM
authors.lastname: Doherty
authors.affiliation: 7 Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Mandel
authors.affiliation: 4 The Mayo Clinic , Rochester, Minnesota.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.affiliation: 8 The Mayo Clinic , Jacksonville, Florida.
authors.forename: Aziza
authors.initials: A
authors.lastname: Nassar
authors.affiliation: 9 The University of Siena , Siena, Italy .
authors.forename: Furio
authors.initials: F
authors.lastname: Pacini
authors.affiliation: 10 Institute Gustave Roussy and University Paris Sud , Villejuif, France .
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
authors.affiliation: 11 Oregon Health and Science University , Portland, Oregon.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Schuff
authors.affiliation: 12 University of Texas M.D. Anderson Cancer Center , Houston, Texas.
authors.forename: Steven I
authors.initials: SI
authors.lastname: Sherman
authors.affiliation: 1 University of Colorado School of Medicine , Aurora, Colorado.
authors.forename: Hilary
authors.initials: H
authors.lastname: Somerset
authors.affiliation: 13 Duke University School of Medicine , Durham, North Carolina.
authors.forename: Julie Ann
authors.initials: JA
authors.lastname: Sosa
authors.affiliation: 14 University of Cincinnati Medical Center , Cincinnati, Ohio.
authors.forename: David L
authors.initials: DL
authors.lastname: Steward
authors.affiliation: 15 MedStar Washington Hospital Center , Washington, DC.
authors.forename: Leonard
authors.initials: L
authors.lastname: Wartofsky
authors.affiliation: 12 University of Texas M.D. Anderson Cancer Center , Houston, Texas.
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Williams
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D012955:Societies, Medical; D009626:Terminology as Topic; D013964:Thyroid Neoplasms / Q000473:pathology*; D016606:Thyroid Nodule; D014481:United States