title: Scientific evidence for therapeutic effects of Chinese prescription Kangen-karyu from pre-clinical animal experiments.
abstract: Chinese prescription Kangen-karyu, comprised of six crude drugs, has received much attention due to its numerous biological activities. The present study reports therapeutic evidence for Kangen-karyu from pre-clinical animal experiments related to human diseases. Kangen-karyu showed beneficial effects on type 1 diabetes and related complications through the suppression of protein expression related to advanced glycation endproducts and oxidative stress. Kangen-karyu reduced oxidative stress via the regulation of dyslipidemia, and also exerted a renoprotective effect mainly through its antioxidant properties during the development of diabetic nephropathy in type 2 diabetes. In addition, Kangen-karyu showed neuroprotective effects by attenuating the spatial memory impairment and neuronal death induced by diabetes. Kangen-karyu counteracted oxidative stress and ameliorated tissue damage possibly associated with aging. These findings provide scientific evidence to explain the efficacy of Kangen-karyu based on its underlying therapeutic effects.
authors.affiliation: Graduate School of Science and Engineering for Research, University of Toyama.
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.forename: Chan Hum
authors.initials: CH
authors.lastname: Park
authors.forename: Kinzo
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003072:Cognition Disorders / Q000188:drug therapy; D003704:Dementia / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; C468270:Kangen-karyu; D018696:Neuroprotective Agents