title: The Post-mastectomy Pain Syndrome-A Systematic Review of the Treatment Modalities.
abstract: Post-mastectomy pain syndrome (PMPS) is a chronic neuropathic pain condition, affecting many women who have undergone breast cancer surgery. The development of PMPS is complex and the treatment options are limited. In this systematic review, we have analyzed the existing treatment modalities of PMPS. Six studies on five treatments were carefully selected, critically evaluated, and presented. The treatments were: antidepressants, anti-epileptics, topical capsaicin, and autologous fat grafting. Four of these treatments had a significant effect on PMPS. However, most of the studies had several flaws and therefore larger studies of high quality should be performed in the future.
authors.affiliation: Department of Plastic Surgery, Odense University Hospital, Odense, Denmark.
authors.forename: Inga Magdalena
authors.initials: IM
authors.lastname: Larsson
authors.affiliation: Department of Plastic Surgery, Odense University Hospital, Odense, Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Ahm Sørensen
authors.affiliation: Department of Plastic Surgery, Odense University Hospital, Odense, Denmark.
authors.forename: Camilla
authors.initials: C
authors.lastname: Bille
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation; D000287:Administration, Topical; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000601:surgery*; D002211:Capsaicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000009:adverse effects*; D010149:Postoperative Pain / Q000628:therapy*; D014182:Transplantation, Autologous
chemical_list: D000928:Antidepressive Agents; D002211:Capsaicin
keywords: breast cancer; mastectomy; pain; treatment