title: Rs4265085 in GPER1 gene increases the risk for unexplained recurrent spontaneous abortion in Dai and Bai ethnic groups in China.
abstract: Oestrogen receptors are implicated in the pathogenesis of recurrent spontaneous abortion (RSA). Non-genomic oestrogen responses can be mediated by GPER. The prevalence of polymorphisms in GPER1 gene in RSA was assessed in 747 Chinese women from Yunnan province (171 Bai, 258 Chinese Han, 234 Dai, 33 Achang and 51 Jingpo patients). Snapshot technology was used for genotyping the polymorphisms of the GPER1 gene. The rs4265085G was significantly increased in the Dai and Bai groups versus controls (Dai: P < 0.0001, Padj< 0.0001, OR 95% CI 2.34 [1.79 to 3.05]; Bai: P = 0.0004, Padj= 0.0012, OR 95% CI 1.71 [1.27 to 2.31]); recessive model of rs4265085 in the Dai (P = 0.003, Padj= 0.009, OR 95% CI 2.71 [1.38 to 5.30]); Bai (P < 0.0001, Padj< 0.0001, OR 95% CI 3.37 [1.93 to 5.91]). Haplotype frequencies containing rs10269151G-rs4265085G-rs11544331C were separately significantly different in Dai and Bai ethnic groups (Dai: P = 0.0002, Padj= 0.001, OR 95% CI = 2.12 [1.43 to 3.17]; Bai: P = 0.005, Padj= 0.025, OR 95% CI = 1.82 [1.18 to 2.78]) compared with controls. The intron variant rs4265085 may confer risk for RSA in Dai and Bai ethnic groups.
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, China; School of Basic Medical Science, Changsha Medical University, Changsha, China. Electronic address: tlcool318@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Tang
authors.affiliation: Key Laboratory for Fertility Regulation and Berth Heath of Minority Nationalities of Yunnan Province, Judicial Expertise Center, Yunnan Population and Family Planning Research Institute, Kunming, China.
authors.forename: Shui
authors.initials: S
authors.lastname: Zheng
authors.affiliation: School of Basic Medical Science, Changsha Medical University, Changsha, China; Experiment Center for Function, Changsha Medical University, Changsha, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, China; School of Basic Medical Science, Changsha Medical University, Changsha, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, China; School of Basic Medical Science, Changsha Medical University, Changsha, China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Bao
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, China; School of Basic Medical Science, Changsha Medical University, Changsha, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, China; School of Basic Medical Science, Changsha Medical University, Changsha, China.
authors.forename: Ju
authors.initials: J
authors.lastname: Xiang
authors.affiliation: School of Basic Medical Science, Changsha Medical University, Changsha, China; Experiment Center for Function, Changsha Medical University, Changsha, China.
authors.forename: Huaiqing
authors.initials: H
authors.lastname: Luo
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, China; Department of Neurology, Xiang-ya Hospital, Central South University, Changsha, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Li
mesh_terms: D000026:Abortion, Habitual / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011960:Receptors, Estrogen / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012307:Risk Factors
chemical_list: C109584:GPER1 protein, human; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled
keywords: Bai ethnic group; Dai ethnic group; GPER1; Genetic association; Recurrent spontaneous abortion (RSA)