title: Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients.
abstract: Thein vitroactivities of amphotericin B in combination with rifampin were assessed against 95 ocular fungal isolates. The interactions between amphotericin B and rifampin at 4, 8, 16, and 32 μg/ml were synergistic for 11.8%, 51.0%, 90.2%, and 94.1%, respectively, ofFusarium solanispecies complex isolates and for 13.6%, 45.5%, 93.2%, and 95.5%, respectively, ofAspergillus flavusspecies complex isolates. Antagonism was never observed for the amphotericin B-rifampin combinations.
authors.affiliation: Cornea Service, Henan Eye Institute & Henan Eye Hospital, and Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Optometry, Zhengzhou Railway Vocational & Technical College, Zhengzhou, Henan, China.
authors.forename: Lutan
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, Zhengzhou Second Hospital, Zhengzhou, Henan, China.
authors.forename: Chuanwen
authors.initials: C
authors.lastname: Gao
authors.affiliation: Laboratory of Ocular Microbiology, Henan Eye Institute & Henan Eye Hospital, and Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.affiliation: Laboratory of Ocular Pharmacology, Henan Eye Institute & Henan Eye Hospital, and Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China xuyan990301@foxmail.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D004338:Drug Combinations; D004357:Drug Synergism; D005670:Fusarium / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D006801:Humans; D007634:Keratitis / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D012293:Rifampin / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D000666:Amphotericin B; D012293:Rifampin
keywords: Aspergillus flavus species complex; Fusarium solani species complex; amphotericin B; fungal keratitis; rifampin; synergistic activity