title: [Atypical femoral fracture and Bisphosphonate.]
abstract: Bisphosphonate therapy had been spread widely in osteoporosis patients, atypical femoral fractures(AFF)were reported in these patients as the unusual effects of bisphosphonate treatment. The pathogenesis of AFF was considered to be an over suppression of bone turnover by bisphosphonate. However recent studies indicated other factors related to AFF initiation. Further studies are required to clarify the mechanism of AFF in order to resolve this adverse events in osteoporosis clinic.
authors.affiliation: Department of orthopedic surgery, Niigata rehabilitation hospital/Niigata bone science institute, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yamamoto
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D016723:Bone Remodeling; D004164:Diphosphonates / Q000627:therapeutic use*; D005264:Femoral Fractures / Q000517:prevention & control*; D006801:Humans
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates