title: Use of topical sirolimus in the management of multiple familial trichoepitheliomas.
abstract: The management of trichoepitheliomas is challenging, especially in children. This challenge is exemplified in patients with multiple trichoepitheliomas who present with progression of lesion count and size despite treatment with current strategies, including CO2laser and surgery. We present the novel use of topical 1% sirolimus cream in two siblings with multiple facial trichoepitheliomas; one was treated with a combination of CO2laser ablation and topical sirolimus, and the other was treated with topical sirolimus alone. Both siblings had a reduction in the growth of new lesions with no reported side effects. This is the first report demonstrating that topical sirolimus, either in combination with CO2laser or alone, can be a promising treatment for trichoepitheliomas.
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, New York.|Department of Dermatology, Stanford University, Palo Alto, California.
authors.forename: Joanna H
authors.initials: JH
authors.lastname: Tu
authors.affiliation: Department of Dermatology, Stanford University, Palo Alto, California.
authors.forename: Joyce M C
authors.initials: JM
authors.lastname: Teng
mesh_terms: D000287:Administration, Topical; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001706:Biopsy; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation; D054020:Lasers, Gas / Q000627:therapeutic use; D008297:Male; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000188:drug therapy*; D020123:Sirolimus / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D020123:Sirolimus
keywords: Brooke-Spiegler; pediatric; sirolimus; topical treatment; trichoepithelioma