title: [Practices of caregivers and national recommendations for treatment of malaria in Benin in 2009].
abstract: New treatments against malaria (artemisinin-based combination therapies, ACT) resulted in profound changes in the therapeutic behaviours in Africa. This study aims to evaluate the practices adaptation to the new strategies in Benin in 2009. In three southern areas of the country, 14 private pharmacies, 10 public health centers and 10 private health centers were audited. Between July and October 2009, 36 providers and 93 prescribers were interviewed, 127 dispensations for self-medication were observed, 210 prescriptions were analyzed according to the WHO recommendations, 251 patients with complaints of malaria and 50 healthy women were interviewed and 34 physical inventories were conducted in pharmacies. Knowledge and trainings were inadequate, especially in the private sector and for the providers, as 41.6% of requests for antimalarial drugs were without prescription in private pharmacies. Only 28% of prescribers and 47% of providers knew the national recommendations of 1st line treatment for uncomplicated malaria. 53% of prescribers treated patients by ACT without prior parasitological examination in the case of uncomplicated malaria and no Rapid Diagnostic Test (RDT) was carried out or requested during the dispensation. Pharmaceutical advices were absent in 78.7% of cases and population acknowledged a lack of knowledge about use of the treatment. Private pharmacies were structures where the variability of available antimalarial drugs was the largest, up to 70 different specialities and where unit prices were highest, up to 7.7 times those charged in public health centers. In the field, the difficulties of application of recommendations, given at the scientific or political level, show the necessity of accompanying policy change by prior training activities of all health stakeholders and of adapting the previous regulations to facilitate implementation of the new rules. The number of authorizations issued for the ACT should be limited; authorization to chloroquine and oral formulations of artemisinin monotherapy should be removed. Since the private sector is actually involved in the fight against malaria, one should provide in this sector ACT and rapid diagnostic tests at subsidized prices.
authors.affiliation: , 38 rue de Montbret, 76000, Rouen, France. sandie_robin@yahoo.com.|ReMeD, 35 rue Daviel, 75013, Paris, France. sandie_robin@yahoo.com.
authors.forename: S
authors.initials: S
authors.lastname: Robin
authors.affiliation: ReMeD, 35 rue Daviel, 75013, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bruneton
authors.affiliation: ReMeD, 35 rue Daviel, 75013, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Guévart
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage* / Q000191:economics; D037621:Artemisinins / Q000008:administration & dosage / Q000191:economics; D001291:Attitude of Health Personnel; D001541:Benin / Q000453:epidemiology; D017028:Caregivers / Q000592:standards* / Q000706:statistics & numerical data; D002738:Chloroquine / Q000008:administration & dosage / Q000191:economics; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination / Q000191:economics / Q000592:standards; D005260:Female; D019983:Guideline Adherence / Q000706:statistics & numerical data*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008288:Malaria / Q000191:economics / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000592:standards* / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D002738:Chloroquine; C031327:artemisinin
keywords: ACT; Artemisinin-based combination therapy; Benin; Come; Cotonou; Dantokpa Market; Malaria; Ouidah; RDT; Rapid diagnostic test; Recommendations; Sub-Saharan Africa; Treatment