title: Ir/PTC cooperatively catalyzed asymmetric umpolung allylation of α-imino ester enabled synthesis of α-quaternary amino acid derivatives bearing two vicinal stereocenters.
abstract: A novel Ir/PTC (phase-transfer catalyst) cooperatively catalyzed asymmetric umpolung allylation of simple α-imino esters is developed and it provides facile access to α-quaternary amino acid derivatives bearing two vicinal stereocenters. Both the metal catalyst and the phase-transfer catalyst are crucial for this methodology. The reaction features good yields, high diastereo- and enantio-selectivities, ease of scale-up to gram scale and further transformation of the products (e.g. to quaternary proline analogues with multi stereocenters).
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. hanzy2014@ustc.edu.cn.
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Su
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. hanzy2014@ustc.edu.cn.
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. hanzy2014@ustc.edu.cn.
authors.forename: Yu-Gen
authors.initials: YG
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. hanzy2014@ustc.edu.cn.
authors.forename: Zhi-Yong
authors.identifier: http://orcid.org/0000-0002-9225-5064
authors.initials: ZY
authors.lastname: Han