title: A Smart, Photocontrollable Drug Release Nanosystem for Multifunctional Synergistic Cancer Therapy.
abstract: Multifunctional synergistic therapy holds promise in biomedical studies and clinical practice. However, strategies aimed at easily integrating the components of such multimodal therapies are needed. Therefore, we herein report a smart drug release nanosystem able to perform photodynamic therapy, photothermal therapy and chemotherapy in a photocontrollable manner. Doxorubicin (DOX), a chemotherapy drug, and 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP4), a photosensitizer, were physically intercalated into a DNA assembly immobilized on gold nanorods. The drugs were efficiently delivered to target cells and released under light irradiation, resulting in a synergism that combined phototherapy and chemotherapy for cancer treatment. This smart, photocontrollable drug release nanosystem promises precisely controlled drug release for multifunctional synergistic cancer therapy.
authors.affiliation: Molecular Science and Biomedicine Laboratory, College of Biology, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University , Changsha 410082, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Molecular Science and Biomedicine Laboratory, College of Biology, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University , Changsha 410082, China.
authors.forename: Huijing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Molecular Science and Biomedicine Laboratory, College of Biology, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University , Changsha 410082, China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Molecular Science and Biomedicine Laboratory, College of Biology, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University , Changsha 410082, China.
authors.forename: Qiaoling
authors.identifier: http://orcid.org/0000-0001-9487-0944
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Molecular Science and Biomedicine Laboratory, College of Biology, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University , Changsha 410082, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Ye
authors.affiliation: Molecular Science and Biomedicine Laboratory, College of Biology, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University , Changsha 410082, China.|Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Shands Cancer Center, University of Florida Genetics Institute, and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Weihong
authors.identifier: http://orcid.org/0000-0002-8066-1524
authors.initials: W
authors.lastname: Tan
mesh_terms: D004317:Doxorubicin; D065546:Drug Liberation; D006046:Gold; D043942:Nanotubes; D010789:Phototherapy
chemical_list: D006046:Gold; D004317:Doxorubicin
keywords: aptamer; drug release; gold nanorod; multimodal therapy; photodynamic therapy; photothermal therapy