title: Cutaneous Reactions to Targeted Therapy.
abstract: Over the past decade, numerous targeted therapeutic agents have become available for clinical use in the oncologic setting with the hopes of realizing personalized cancer treatment. These agents have achieved great improvements in clinical outcomes for patients suffering from solid and hematologic malignancies. However, adverse cutaneous reactions are among the most common toxicities observed in patients undergoing treatment with a targeted agent and can alter the overall clinical management strategy. For these reasons, the practicing dermatopathologist should be mindful of the breadth and depth of adverse cutaneous reaction patterns associated with this mechanistically diverse array of targeted agents.
authors.affiliation: *Dermatology Resident, University of Pittsburg Medical Center, Pittsburg, PA; Associate Professor, Departments of †Pathology, and ‡Dermatology, Massachusetts General Hospital, Boston, MA; and §Associate Professor, Harvard Medical School, Boston, MA.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Daniela
authors.initials: D
authors.lastname: Kroshinsky
authors.forename: Mai P
authors.initials: MP
authors.lastname: Hoang
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents