title: [Predictors of Overall Survival after Locoregional Breast Cancer Recurrence].
abstract: We evaluated prognostic factors of locoregional breast cancer recurrence in 35 patients. The average age at the time of surgery was 58.4 years(range: 32-87 years). Of the 35 patients, 7, 17, and 11 had Stage I , II and III disease, respectively. Immunohistochemically, 25 tumors were ER+, and 10 were ER-, while 6 were HER2+, 27 were HER2-, and 2 had uncertain HER2 statuses. Their median disease-free interval(DFI), which is the intervalbetween initialsurgery and locoregional recurrence, was 29.4 months(range: 1-133 months). After locoregional relapse, 13 patients underwent surgical tumor removal, and 34 received systemic treatment. The median time-to-progression(TTP)after first-line therapy for recurrent breast cancer was 12.7 months(range: 1-185 months), and the median overall survival(OS)was 70.0 months(range: 3-313 months). Univariate analysis showed that disease stage at initial surgery, triple-negative disease, DFI, and TTP significantly affected OS, whereas ER and HER2 status, surgical margin at primary surgery, lymphovascular invasion, irradiation after initial surgery, and resection of the recurrent tumor were not significant factors. Patients with factors that predict worse prognosis after locoregional recurrence should be treated carefully.
authors.affiliation: Dept. of Surgery, Chiba Rosai Hospital.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kasagawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Fujimori
authors.forename: Natsumi
authors.initials: N
authors.lastname: Ishii
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ozaki
authors.forename: Ikuo
authors.initials: I
authors.lastname: Udagawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence