title: Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region.
abstract: Small-molecule organic fluorophores spectrally active in the 800-950 nm region are sought-after for their broad potential in biomedical and material applications. We have developed a new family of brightly fluorescent dyes (ECX) to meet this challenge. ECX dyes are transparent to the visible region, while strongly absorbing in the NIR region at approximately 880 nm. They emit at around 915 nm with a fluorescence quantum yield up to 13.3 %. ECX dyes exhibit high chemostability, high photostability, and low tendency to aggregate. Other merits of ECX dyes include low degree of solvatochromism and facile post-synthetic derivatization. ECX dyes potentially make available the 800-950 nm region for spectroscopic and microscopic applications and are also expected to find broad material applications.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.
authors.forename: Zuhai
authors.initials: Z
authors.lastname: Lei
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.
authors.forename: Xinran
authors.initials: X
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Luo
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.
authors.forename: Haihong
authors.initials: H
authors.lastname: He
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.|Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.|Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Rd. 130, Shanghai, 200236, China.
authors.forename: Youjun
authors.initials: Y
authors.lastname: Yang
keywords: fluorophores; imaging; near-infrared