title: Systematic Chemoenzymatic Synthesis ofO-Sulfated Sialyl Lewis x Antigens.
abstract: O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes. Taking advantage of a bacterial sialyltransferase mutant that can catalyze the transfer of different sialic acid forms from the corresponding sugar nucleotide donors to Lewis x antigens which are fucosylated glycans as well as an efficient one-pot multienzyme (OPME) sialylation system, O-sulfated sialyl Lewis x antigens containing different sialic acid forms and O-sulfation at different locations were systematically synthesized by chemoenzymatic methods.
authors.affiliation: Department of Chemistry, University of California, Davis One Shields Avenue, Davis, CA 95616 (USA) xiichen@ucdavis.edu.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Santra
authors.affiliation: Department of Chemistry, University of California, Davis One Shields Avenue, Davis, CA 95616 (USA) xiichen@ucdavis.edu.
authors.forename: Hai
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Chemistry, University of California, Davis One Shields Avenue, Davis, CA 95616 (USA) xiichen@ucdavis.edu.
authors.forename: Nova
authors.initials: N
authors.lastname: Tasnima
authors.affiliation: Department of Chemistry, University of California, Davis One Shields Avenue, Davis, CA 95616 (USA) xiichen@ucdavis.edu.
authors.forename: Musleh M
authors.initials: MM
authors.lastname: Muthana
authors.affiliation: Department of Chemistry, University of California, Davis One Shields Avenue, Davis, CA 95616 (USA) xiichen@ucdavis.edu.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of California, Davis One Shields Avenue, Davis, CA 95616 (USA) xiichen@ucdavis.edu; School of Food Science, Henan Institute of Science and Technology, Xinxiang, 453003 (China).
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, CA 95616 (USA).
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Kenyond
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA 95616 (USA).
authors.forename: Angelique Y
authors.initials: AY
authors.lastname: Louie
authors.affiliation: Department of Chemistry, University of California, Davis One Shields Avenue, Davis, CA 95616 (USA) xiichen@ucdavis.edu.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen