title: Research prioritization of men's health and urologic diseases.
abstract: OBJECTIVE
  We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR) reflects disease burden, measured by the Global Burden of Disease (GBD) Study as disability-adjusted life-years (DALYs).
  
  
  METHODS
  Two investigators performed independent assessment of ten men's health and urologic diseases (MHUDs) in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis.
  
  
  RESULTS
  Nine of ten MHUDs were represented by at least one CDSR review. There was a poor and statistically insignificant positive correlation between CDSR representation and disease burden (rho = 0.42, p = 0.23). CDSR representation was aligned with disease burden for three conditions, greater than disease burden for one condition, and less than disease burden for six conditions.
  
  
  CONCLUSIONS
  These results yield high-quality estimates to inform future research prioritization for MHUDs. While prioritization processes are complex and multi-faceted, disease burden should be strongly considered. Awareness of research priority setting has the potential to minimize research disparities on a global scale.
authors.affiliation: University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Okland
authors.affiliation: College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Chante
authors.initials: C
authors.lastname: Karimkhani
authors.affiliation: University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Hannah
authors.initials: H
authors.lastname: Pederson
authors.affiliation: School of Medicine, Georgetown University, Washington, District of Columbia, USA.
authors.forename: Lindsay N
authors.initials: LN
authors.lastname: Boyers
authors.affiliation: Urology Service, Unites States Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, Colorado, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Sawyer
authors.affiliation: Department of Urology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Kyle O
authors.initials: KO
authors.lastname: Rove
authors.affiliation: Department of Urology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: McCabe C
authors.initials: MC
authors.lastname: Kenny
authors.affiliation: Urology Service, Unites States Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, Colorado, USA.|Department of Urology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Steinberg
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USA.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Naghavi
authors.affiliation: Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.|Dermatology Service, Unites States Department of Veterans, Eastern Colorado Health Care System, Denver, Colorado, USA.|Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Dellavalle
mesh_terms: D035843:Biomedical Research / Q000706:statistics & numerical data* / Q000639:trends*; D000071219:Global Burden of Disease; D006801:Humans; D007248:Infertility, Male; D008297:Male; D054526:Men's Health / Q000706:statistics & numerical data* / Q000639:trends*; D019057:Quality-Adjusted Life Years; D012196:Review Literature as Topic; D018709:Statistics, Nonparametric; D013997:Time Factors; D014570:Urologic Diseases; D014571:Urologic Neoplasms
keywords:  Infertility, Male; Men’s Health ; Urologic Diseases