title: Association study between growth hormone receptor (GHR) gene polymorphisms and obesity in Korean population.
abstract: A main target of growth hormone (GH) is adipose tissue in human body. The GH secretion in obesity patients is impaired. It is needless to say that growth hormone receptor (GHR) is necessary in GH hormone signaling. The purpose of the present study is to examine the association between single nucleotide polymorphisms (SNPs) and the development of obesity. A total of 211 overweight/obese subjects with a body mass index (BMI) ≥23 kg/m2and 157 nonoverweight/obese controls with a BMI of 18.5-23.0 kg/m2were involved in this study. Seven SNPs including the rs6451620 (intron), rs4130114 (intron), rs4410646 (intron), rs6898743 (intron), rs4394131 (intron), rs6182 (Cys440Phe), and rs6184 (Pro579Thr) and rs2229765 SNPs ofGHRgene were genotyped. Genotyping was performed using custom DNA chip. SNPStats was used to calculate the odds ratio, 95% confidence interval, andP-value. The link-age disequilibrium block and haplotypes among seven SNPs were determined using Haploview version 4.2. Dominant, recessive, and log-additive genetic models were conducted for genetic analyzing. Among tested SNPs inGHRgene, rs4410646 and rs6898743 showed significant association with obesity (rs4410646,P=0.02 in dominant model andP=0.036 in log-additive model; rs6898743,P=0.039 in dominant model andP=0.044 in log-additive model). In summary, these results suggest thatGHRgene polymorphisms might play a role in the development of obesity in the Korean population.
authors.affiliation: College of Nursing, Sungshin Women's University, Seoul, Korea.
authors.forename: Seung-Ae
authors.initials: SA
authors.lastname: Yang
keywords: GHR; Growth receptor hormone; Obesity; Overweight/obese; Single nucleotide polymorphism