title: A case report of combination treatment with potassium-titanyl phosphate laser and brimonidine topical gel in erythematotelangiectatic rosacea.
abstract: Laser therapies have been shown to provide symptom improvement in patients with erythema and telangiectasia of rosacea; however, they are associated with side effects such as erythema. Combinatorial treatment with pharmacological agents and laser have demonstrated better efficacy, fewer side effects and continued long-term remission compared with monotherapies. A case of moderate facial erythema that responded well to combination treatment with brimonidine 3 mg/g gel and a treatment course of potassium-titanyl phosphate (KTP) laser therapy is presented, showing a reduction from baseline, maintained after final laser session, by applying brimonidine 3 mg/g gel daily. Using brimonidine 3 mg/g gel to target post-laser treatment erythema is highly effective in minimising refractory erythema. Continued use of brimonidine 3 mg/g gel provides a sustained reduction of erythema, increasing the visibility of other signs and symptoms of rosacea that may be present. This can facilitate the treatment of these additional signs and symptoms.
authors.affiliation: a Department of Dermatology , Venerology and Allergology, Charité Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Maja A
authors.initials: MA
authors.lastname: Hofmann
authors.affiliation: a Department of Dermatology , Venerology and Allergology, Charité Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kokolakis
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000068438:Brimonidine Tartrate / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D010710:Phosphates / Q000627:therapeutic use; D011188:Potassium / Q000627:therapeutic use; D012393:Rosacea / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D010710:Phosphates; D000068438:Brimonidine Tartrate; D011188:Potassium
keywords: Brimonidine gel; KTP laser therapy; persistent erythema; rosacea