title: Synthesis of α-Quaternary Formimides and Aldehydes through Umpolung Asymmetric Copper Catalysis with Isocyanides.
abstract: A highly regio- and enantioselective copper-catalyzed three-component coupling of isocyanides, hydrosilanes, and γ,γ-disubstituted allylic phosphates/chlorides to afford chiral α-quaternary formimides was enabled by the combined use of our original chiral naphthol-carbene ligand as a functional Cu-supporting ligand and LiOtBu as a stoichiometric Lewis base for Si. The formimides were readily converted to α-quaternary aldehydes.
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University , Sapporo 060-0810, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hojoh
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University , Sapporo 060-0810, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Ohmiya
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University , Sapporo 060-0810, Japan.
authors.forename: Masaya
authors.identifier: 0000-0002-8770-2982
authors.initials: M
authors.lastname: Sawamura