title: The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock.
abstract: The effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and maintenance of mesenteric microvascular function were explored in a rat model of hemorrhagic shock (HS). Following controlled hemorrhage, rats were infused with equal volumes of either pPolyHb, hetastarch (HES), or red blood cell (RBC). The results showed that pPolyHb was superior to HES and RBC in restoring hemodynamic stability and reversing anaerobic metabolism. We observed a reduction in the diameter of mesenteric microvasculature after HS. Resuscitation with pPolyHb and RBC was able to restore the diameters of the venules and arterioles, whereas HES failed to restore the diameters during the observation period.
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.|d Department of Anesthesiology , Xijing Hospital, Fourth Military Medical University , Xi'an , P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.
authors.forename: Chengbin
authors.initials: C
authors.lastname: Yan
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Xu
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.
authors.forename: Kunping
authors.initials: K
authors.lastname: Yan
authors.affiliation: c Shaanxi Lifegen Co. Ltd , Xi'an , P. R. China.
authors.forename: Bao
authors.initials: B
authors.lastname: Feng
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.
authors.forename: Mengye
authors.initials: M
authors.lastname: Zhao
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.
authors.forename: Geng
authors.initials: G
authors.lastname: Niu
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.
authors.forename: Mengdi
authors.initials: M
authors.lastname: Wu
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.|b National Engineering Research Center for Miniaturized Detection Systems, Northwest University , Xi'an , P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: a College of Life Science, Northwest University , Xi'an , P. R. China.|b National Engineering Research Center for Miniaturized Detection Systems, Northwest University , Xi'an , P. R. China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000138:Acidosis / Q000150:complications; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000503:physiopathology*; D008833:Microcirculation / Q000187:drug effects*; D051381:Rats; D012771:Shock, Hemorrhagic / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*; D013552:Swine
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; C079129:hemoglobin polymer
keywords: Polymerized porcine hemoglobin; hemodynamic stability; hemorrhagic shock; mesenteric microcirculation