title: Individuality manifests in the dynamic reconfiguration of large-scale brain networks during movie viewing.
abstract: Individuality, the uniqueness that distinguishes one person from another, may manifest as diverse rearrangements of functional connectivity during heterogeneous cognitive demands; yet, the neurobiological substrates of individuality, reflected in inter-individual variations of large-scale functional connectivity, have not been fully evidenced. Accordingly, we explored inter-individual variations of functional connectivity dynamics, subnetwork patterns and modular architecture while subjects watched identical video clips designed to induce different arousal levels. How inter-individual variations are manifested in the functional brain networks was examined with respect to four contrasting divisions: edges within the anterior versus posterior part of the brain, edges with versus without corresponding anatomically-defined structural pathways, inter- versus intra-module connections, and rich club edge types. Inter-subject variation in dynamic functional connectivity occurred to a greater degree within edges localized to anterior rather than posterior brain regions, without adhering to structural connectivity, between modules as opposed to within modules, and in weak-tie local edges rather than strong-tie rich-club edges. Arousal level significantly modulates inter-subject variability in functional connectivity, edge patterns, and modularity, and particularly enhances the synchrony of rich-club edges. These results imply that individuality resides in the dynamic reconfiguration of large-scale brain networks in response to a stream of cognitive demands.
authors.affiliation: BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.|Department of Nuclear Medicine, Department of Radiology, Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Changwon
authors.initials: C
authors.lastname: Jang
authors.affiliation: Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street Belmont, MA 02478, USA.
authors.forename: Elizabeth Quattrocki
authors.initials: EQ
authors.lastname: Knight
authors.affiliation: BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.|Department of Nuclear Medicine, Department of Radiology, Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Chongwon
authors.initials: C
authors.lastname: Pae
authors.affiliation: Department of Statistics, Hankuk University of Foreign Studies, Yong-In, Republic of Korea.
authors.forename: Bumhee
authors.initials: B
authors.lastname: Park
authors.affiliation: Department of Nuclear Medicine, Department of Radiology, Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.|Department of Cognitive Science, Yonsei University, Seoul, Republic of Korea.
authors.forename: Shin-Ae
authors.initials: SA
authors.lastname: Yoon
authors.affiliation: BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.|Department of Nuclear Medicine, Department of Radiology, Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.|Department of Cognitive Science, Yonsei University, Seoul, Republic of Korea.
authors.forename: Hae-Jeong
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009040:Motion Pictures; D009415:Nerve Net / Q000502:physiology*; D013223:Statistics as Topic