title: Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification.
abstract: Background. Insulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results. The purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0).Methods. In 1201 subjects (52% women, 53.6 ± 9.3 years old) without familiar and personal history of coronary heart disease, CAC and AVC were assessed by multidetector-computed tomography. Cardiovascular risk factors were documented and lipid profile, inflammation markers, glucose, insulin, and free fatty acids were measured. Hepatic insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR) indices were calculated.Results. There was a significant relationship between HOMA-IR and Adipo-IR indices (r= 0.758,p< 0.001). Participants in the highest quartiles of HOMA-IR and Adipo-IR indices had a more adverse cardiovascular profile and higher prevalence of CAC > 0 and AVC > 0. After full adjustment, subjects in the highest quartile of Adipo-IR index had higher odds of AVC > 0 (OR: 2.40; 95% CI: 1.30-4.43), as compared to those in the lowest quartile.Conclusions. Adipo-IR was independently associated with AVC > 0. This suggests that abnormal adipose tissue function favors insulin resistance that may promote the development and progression of AVC.
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Esteban
authors.initials: E
authors.lastname: Jorge-Galarza
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Carlos
authors.identifier: 0000-0002-0546-9794
authors.initials: C
authors.lastname: Posadas-Romero
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Margarita
authors.initials: M
authors.lastname: Torres-Tamayo
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Aida X
authors.identifier: 0000-0003-1934-5095
authors.initials: AX
authors.lastname: Medina-Urrutia
authors.affiliation: Cardiolology Department, San Juan de Dios General Hospital, Guatemala, Guatemala.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Rodas-Díaz
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.affiliation: Molecular Biology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Gilberto
authors.identifier: 0000-0001-7916-5163
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: María Del Carmen
authors.initials: MD
authors.lastname: González-Salazar
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Guillermo C
authors.initials: GC
authors.lastname: Cardoso-Saldaña
authors.affiliation: Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
authors.forename: Juan G
authors.identifier: 0000-0001-8864-2304
authors.initials: JG
authors.lastname: Juárez-Rojas
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D001786:Blood Glucose / Q000378:metabolism; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides