title: Risk factors associated with failure of extubation in very-low-birth-weight newborns.
abstract: OBJECTIVE
  To identify risk factors associated with the failure of extubation of mechanically ventilated very-low-birth-weight newborns.
  
  
  METHODS
  Prospective observational study. Assessment of the occurrence of extubation failure in relation to demographic and ventilation parameters, the SpO2/FiO2ratio, the spontaneous breathing test (SBT) and values of the Silverman-Andersen score (SAS). Extubation failure was defined as the need for reintubation for any reason within 72 h after extubation.
  
  
  RESULTS
  Extubation failed in 14/50 (28%) patients. Tidal volume applied at the moment of extubation (p = 0.030), the values of the SpO2/FiO2ratio (p = 0.006), SBT (p = 0.034) and SAS measured for 60 min after extubation and later (p = 0.010, p = 0.000001, p∼0.000, respectively) showed a significant association with reintubation.
  
  
  CONCLUSIONS
  Measured TV, SpO2/FiO2ratio, SBT at the moment of extubation and values of SAS starting 1 h after extubation might be valuable parameters in identifying those VLBW newborns in the risk to fail extubation.
authors.affiliation: a Department of Intensive Care , Institute of Child and Youth Healthcare of Vojvodina , Novi Sad , Serbia.|b Medical Faculty , University of Novi Sad , Novi Sad , Serbia.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Spasojevic
authors.affiliation: a Department of Intensive Care , Institute of Child and Youth Healthcare of Vojvodina , Novi Sad , Serbia.|b Medical Faculty , University of Novi Sad , Novi Sad , Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Doronjski
mesh_terms: D060666:Airway Extubation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D017211:Treatment Failure
keywords: Risk factors; extubation; failure; newborn; very-low-birth-weight