title: The clinical value of lncRNA NEAT1 in digestive system malignancies: A comprehensive investigation based on 57 microarray and RNA-seq datasets.
abstract: This comprehensive investigation was performed to evaluate the expression level and potential clinical value of NEAT1 in digestive system malignancies. A total of 57 lncRNA datasets of microarray or RNA-seq and 5 publications were included. The pooled standard mean deviation (SMD) indicated that NEAT1 was down-regulated in esophageal carcinoma (ESCA, SMD = -0.35, 95% CI: -0.5~-0.20, P < 0.0001) and hepatocellular carcinoma (HCC, SMD = -0.47, 95% CI: -0.60~-0.34, P < 0.0001), while in pancreatic cancer (PC), NEAT1 was up-regulated (SMD = 0.45, 95% CI: 0.2~0.71, P = 0.001). However, NEAT1 expression in gastric cancer (GC), colorectal cancer (CRC), biliary tract cancer (BTC) and gallbladder carcinoma (GBC) showed no significant difference between cancer and control groups. The pooled area under the curve values for ESCA, GC, CRC, PC and HCC were 0.60, 0.89, 0.81, 0.77 and 0.69, respectively. Furthermore, our result demonstrated that a high expression of NEAT1 predicted an unfavorable prognosis in patients with digestive system malignancies (HR: 1.50, 95% CI: 1.28-1.76, P < 0.0001). Our study suggests that NEAT1 may play different roles in the initiation and progression of digestive system cancers and could be a potential diagnostic and prognostic biomarker in patients with digestive system carcinomas. Further and stricter studies with a larger number of cases are necessary to strengthen our conclusions.
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Xiong
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Zhen-Bo
authors.initials: ZB
authors.lastname: Feng
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Wei-Luan
authors.initials: WL
authors.lastname: Cen
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zeng
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Tang
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Gan
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Hai-Wei
authors.initials: HW
authors.lastname: Liang
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Zu-Yun
authors.initials: ZY
authors.lastname: Li
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Zhuang, China.
authors.forename: Dian-Zhong
authors.initials: DZ
authors.lastname: Luo
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: C577276:NEAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding
keywords: NEAT1; clinical value; digestive system malignancies; lncRNA; microarray and RNA-seq datasets