title: Circulating-tumor DNA as an early detection and diagnostic tool.
abstract: The development of new circulating-tumor DNA (ctDNA) analysis techniques has led to an explosion of studies demonstrating exciting clinical applications. Non-invasive genotyping can characterize mutations of interest without the need for an invasive biopsy. Serial ctDNA monitoring can assess response to treatment, and potentially identify mechanisms of resistance. Perhaps most excitingly, sensitive ctDNA analysis methods allow for detection of minimally residual disease, predicting recurrence months before clinical presentation. In this review, we highlight several recent, key studies in the ctDNA field and discuss future advances which would further improve patient care.
authors.affiliation: Oregon Health and Science University Knight Cancer Institute, Mail Code CR145, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, United States; Oregon Health and Science University Department of Molecular and Medical Genetics, 3181 SW Sam Jackson Park Road L103, Portland, OR 97239-3098, United States.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Butler
authors.affiliation: Oregon Health and Science University Knight Cancer Institute, Mail Code CR145, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, United States; Oregon Health and Science University Department of Molecular and Medical Genetics, 3181 SW Sam Jackson Park Road L103, Portland, OR 97239-3098, United States.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Spellman
authors.affiliation: Oregon Health and Science University Department of Biomedical Engineering, Mail Code CL3G, 2730 SW Moody Ave., Portland, OR 97201-5042, United States; Oregon Health and Science University Knight Cancer Institute, Mail Code CR145, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, United States; Oregon Health and Science University Center for Spatial System Biomedicine, Collaborative Life Sciences Building, 2730 SW Moody Ave, Mail Code CL3G, Portland, OR 97201-5042, United States. Electronic address: grayjo@ohsu.edu.
authors.forename: Joe
authors.initials: J
authors.lastname: Gray
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D000074141:Circulating Tumor DNA / Q000235:genetics* / Q000302:isolation & purification; D055088:Early Detection of Cancer; D005838:Genotype; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D000074141:Circulating Tumor DNA