title: Palladium-catalyzed carbonylative synthesis of isocoumarins and phthalides by using phenyl formate as a carbon monoxide source.
abstract: A simple and efficient palladium-catalyzed intramolecular carbonylative synthesis of isocoumarins and phthalides from the easily available starting materials by employing phenyl formate as a CO surrogate has been achieved. The approach affords target compounds in good to excellent yields with the advantages of lower toxicity, milder conditions, easy operation and wide functional group tolerance.
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. zhuyongming@suda.edu.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yuan
authors.forename: Zhen-Bang
authors.initials: ZB
authors.lastname: Chen
authors.forename: Fang-Ling
authors.initials: FL
authors.lastname: Zhang
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Zhu
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D005561:Formates / Q000737:chemistry*; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D005561:Formates; D049934:Isocoumarins; D010165:Palladium; D002248:Carbon Monoxide; C082022:phthalide