title: Plasma Omentin-1 Level as a Predictor of Good Coronary Collateral Circulation.
abstract: OBJECTIVE
  Coronary collateral circulation (CCC) is crucial during an acute ischemic attack. Evidences showed that omentin-1 exhibited remarkable antiatherogenic effects and ischemia-induced revascularization. The aim of this study was to investigate the relationship between plasma omentin-1 levels and CCC in patients with ≥90% angiography-proven coronary occlusion.
  
  
  METHODS
  142 patients with ≥90% luminal diameter stenosis in at least one major epicardial coronary artery were recruited. Among them, 79 patients with Rentrop 0-1 grade were classified into the poor CCC group and 63 patients with Rentrop 2-3 grade were included into the good CCC group. The association between plasma omentin-1 levels and CCC status was assessed.
  
  
  RESULTS
  Plasma omentin-1 level was significantly higher in patients with good CCC than those with poor CCC (566.57±26.90 vs. 492.38±19.70 ng/mL, p=0.024). Besides, omentin-1 was positively correlated with total cholesterol (TC), high-density lipoprotein, and gensini score but inversely with hyperlipidemia and body mass index (all p values＜0.05). Multivariate regression analysis indicated that omentin-1 [odds ratio (OR)=1.002, 95% confidence interval (CI): 1.000-1.004, p=0.041)], TC, the number of the diseased vessels, a higher frequency of left circumflex artery and right coronary artery, chronic total occlusion, and gensini score remained as the independent predictors of good CCC.
  
  
  CONCLUSIONS
  Higher plasma omentin-1 level was associated with better CCC development. Our findings suggest that omentin-1 may be an alternative marker for adequate CCC in patients with ≥90% coronary occlusion.
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University.
authors.forename: Ji-Peng
authors.initials: JP
authors.lastname: Zhou
authors.affiliation: Department of Geriatric Medicine, Xiangya Hospital, Central South University.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Tong
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University.
authors.forename: Ling-Ping
authors.initials: LP
authors.lastname: Zhu
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University.
authors.forename: Jing-Min
authors.initials: JM
authors.lastname: Luo
authors.affiliation: Department of Geriatric Medicine, Xiangya Hospital, Central South University.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Geriatric Medicine, Xiangya Hospital, Central South University.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Bai
authors.affiliation: Department of Geriatric Medicine, Xiangya Hospital, Central South University.
authors.forename: Chuan-Chang
authors.initials: CC
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University.
authors.forename: Guo-Gang
authors.initials: GG
authors.lastname: Zhang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003097:Collateral Circulation / Q000502:physiology*; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D054059:Coronary Occlusion / Q000097:blood / Q000000981:diagnostic imaging; D023921:Coronary Stenosis / Q000097:blood* / Q000000981:diagnostic imaging; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D037102:Lectins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D008075:Lipoproteins, HDL; D002784:Cholesterol
keywords: Coronary collateral circulation; Coronary heart disease; Omentin-1