title: Association of IGF1 polymorphism rs6214 with high myopia: A systematic review and meta-analysis.
abstract: To conduct a comprehensive evaluation of the association of Insulin-like growth factor 1 (IGF1) polymorphism rs6214 with high myopia through a systematic review and meta-analysis of candidate genetic association study.
  
  
  
  All case-control association studies on IGF1 and high myopia reported up to 15 June 2016 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for single-nucleotide polymorphism (SNP) using fixed and random effects models according to between study heterogeneity. Publication bias analyses were conducted using Begg's test.
  
  
  
  A total of eight studies from published articles were included in our analysis. The meta-analyses for IGF1 rs6214, composed of 4242 high myopia patients and 4430 controls, showed low heterogeneity for the included populations in all the genetic models, except that of the allelic genetic model in the pooled populations. The analyses of all the genetic models in Chinese, Japanese, and overall pooled populations did not identify any significant association between high myopia and IGF1 rs6214.
  
  
  
  This meta-analysis showed there was no association detected between IGF1 rs6214 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.
authors.affiliation: a Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , Sichuan , China.
authors.forename: Dingding
authors.initials: D
authors.lastname: Zhang
authors.affiliation: b Department of Clinical Laboratory , People's Hospital of Pengzhou , Pengzhou , Sichuan , China.
authors.forename: Guangqun
authors.initials: G
authors.lastname: Zeng
authors.affiliation: c Institute of Health Policy and Hospital Management, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital , Chengdu , Sichuan , China.|d School of Public Health , Sichuan University , Chengdu , Sichuan , China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Hu
authors.affiliation: e College of Science and Mathematics , California Polytechnic State University , San Luis Obispo , California , USA.
authors.forename: Kerry
authors.initials: K
authors.lastname: McCormick
authors.affiliation: a Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , Sichuan , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.affiliation: a Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , Sichuan , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Gong
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D056726:Genetic Association Studies; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D047728:Myopia, Degenerative / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I
keywords: High myopia; IGF1; meta-analysis; rs6214