title: Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study.
abstract: BACKGROUND
  Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.
  
  
  METHODS
  Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs).
  
  
  RESULTS
  High tau burden was associated with aging and low-level education in PiB(-)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(-)-HC.
  
  
  CONCLUSIONS
  The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimada
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kitamura
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan; Neurology Chiba Clinic, Chiba-shi, Chiba, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shinotoh
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan; Division of Neurology, Kobe University Graduate School of Medicine, Kobe-shi, Hyogo, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Endo
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan; Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto-shi, Kyoto, Japan.
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Niwa
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hirano
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Department of Radiopharmaceuticals Development, Clinical Research Cluster, NIRS, QST, Chiba-shi, Chiba, Japan.
authors.forename: Ming-Rong
authors.initials: MR
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
authors.affiliation: Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Higuchi
keywords: Aging; Alzheimer's disease; Amyloid; Biomarkers; Brain atrophy; Cognitive decline; Cognitive reserve; Dementia; MCI; Positron emission tomography; Preclinical; Tau; [11C]PBB3; [11C]PiB