title: Pathogenic bacteria distributions and drug resistance analysis in 96 cases of neonatal sepsis.
abstract: This study aimed to summarize common pathogens and associated drug resistance in neonatal sepsis (NS).
  
  
  
  Blood culture and drug sensitivity results from 96 NS cases treated from January 2010 to August 2014 were retrospectively analyzed.
  
  
  
  A total of 97 pathogenic bacteria were detected from these 96 NS cases; Gram-positive cocci accounted for 76.3% of the cases, among which 70.1% involved coagulase-negative staphylococcus (CONS), whereas Gram-negative bacilli and fungi accounted for 19.6% and fungi 4.1% of cases, respectively. Gram-positive cocci exhibited a higher penicillin resistance rate and full vancomycin sensitivity, whereas Gram-negative bacilli exhibited a higher cephalosporin resistance rate, low meropenem resistance rate (6.7%), and no resistance to amikacin.
  
  
  
  The main causative pathogens of NS in our hospital were Gram-positive cocci, among which coagulase-negative Staphylococcus spp such as S. epidermidis and S. haemolyticus were the main conditional pathogens; among Gram-negative pathogens, Klebsiella pneumoniae were most frequently isolated and showed widespread resistance to penicillins and cephalosporins.
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, Anhui, China.
authors.forename: Huaifu
authors.initials: H
authors.lastname: Dong
authors.affiliation: Department of Pediatrics, the Third People's Hospital of Bengbu, Bengbu, 233000, Anhui, China.
authors.forename: Huiping
authors.initials: H
authors.lastname: Cao
authors.affiliation: Department of Nursing, the First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, Anhui, China. haiyanzhengcn@163.com.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zheng
mesh_terms: D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D000071074:Neonatal Sepsis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D012189:Retrospective Studies
keywords: Drug resistance; Neonatal sepsis; Pathogen