title: MicroRNA-29: A Crucial Player in Fibrotic Disease.
abstract: Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases.
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.
authors.forename: Zhenjun
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.|Department of Plastic Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Yongjing
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.
authors.forename: Xujuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Biochemistry, Wheaton College, Norton, Massachusetts, USA.
authors.forename: Ao
authors.initials: A
authors.lastname: Shi
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. minimillet@hotmail.com.|Department of Physiology, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China. minimillet@hotmail.com.
authors.forename: Lechun
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. heli2661@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: He
mesh_terms: D005355:Fibrosis / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D007627:Keloid / Q000235:genetics; D007668:Kidney / Q000473:pathology; D008103:Liver Cirrhosis / Q000235:genetics; D035683:MicroRNAs / Q000502:physiology*; D009206:Myocardium / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000235:genetics; D012595:Scleroderma, Systemic / Q000235:genetics
chemical_list: C532045:MIRN29a microRNA, human; D035683:MicroRNAs