title: Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies.
abstract: OBJECTIVE
  To examine the role of psychological distress (anxiety and depression) as a potential predictor of site specific cancer mortality.
  
  
  METHODS
  Pooling of individual participant data from 16 prospective cohort studies initiated 1994-2008.
  
  
  METHODS
  Nationally representative samples drawn from the health survey for England (13 studies) and the Scottish health survey (three studies).
  
  
  METHODS
  163 363 men and women aged 16 or older at study induction, who were initially free of a cancer diagnosis, provided self reported psychological distress scores (based on the general health questionnaire, GHQ-12) and consented to health record linkage.
  
  
  METHODS
  Vital status records used to ascertain death from 16 site specific malignancies; the three Scottish studies also had information on cancer registration (incidence).
  
  
  RESULTS
  The studies collectively contributed an average of 9.5 years of mortality surveillance during which there were 16 267 deaths (4353 from cancer). After adjustment for age, sex, education, socioeconomic status, body mass index (BMI), and smoking and alcohol intake, and with reverse causality (by left censoring) and missing data (by imputation) taken into account, relative to people in the least distressed group (GHQ-12 score 0-6), death rates in the most distressed group (score 7-12) were consistently raised for cancer of all sites combined (multivariable adjusted hazard ratio 1.32, 95% confidence interval 1.18 to 1.48) and cancers not related to smoking (1.45, 1.23 to 1.71), as well as carcinoma of the colorectum (1.84, 1.21 to 2.78), prostate (2.42, 1.29 to 4.54), pancreas (2.76, 1.47 to 5.19), oesophagus (2.59, 1.34 to 5.00), and for leukaemia (3.86, 1.42 to 10.5). Stepwise associations across the full range of distress scores were observed for colorectal and prostate cancer.
  
  
  CONCLUSIONS
  This study contributes to the growing evidence that psychological distress might have some predictive capacity for selected cancer presentations, in addition to other somatic diseases.
authors.affiliation: Department of Epidemiology and Public Health, University College, London, UK david.batty@ucl.ac.uk.
authors.forename: G David
authors.initials: GD
authors.lastname: Batty
authors.affiliation: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.|Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Tom C
authors.initials: TC
authors.lastname: Russ
authors.affiliation: Charles Perkins Centre, Faculty of Health Sciences, University of Sydney, Sydney, Australia.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Stamatakis
authors.affiliation: Department of Epidemiology and Public Health, University College, London, UK.
authors.forename: Mika
authors.initials: M
authors.lastname: Kivimäki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000150:complications*; D003863:Depression / Q000150:complications*; D004739:England / Q000453:epidemiology; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality* / Q000523:psychology*; D011379:Prognosis; D012606:Scotland / Q000453:epidemiology; D057566:Self Report; D013315:Stress, Psychological / Q000150:complications*; D016019:Survival Analysis; D055815:Young Adult