title: Membrane ion Channels and Receptors in Animal lifespan Modulation.
abstract: Acting in the interfaces between environment and membrane compartments, membrane ion channels, and receptors transduce various physical and chemical cues into downstream signaling events. Not surprisingly, these membrane proteins play essential roles in a wide range of cellular processes such as sensory perception, synaptic transmission, cellular growth and development, fate determination, and apoptosis. However, except insulin and insulin-like growth factor receptors, the functions of membrane receptors in animal lifespan modulation have not been well appreciated. On the other hand, although ion channels are popular therapeutic targets for many age-related diseases, their potential roles in aging itself are largely neglected. In this review, we will discuss our current understanding of the conserved functions and mechanisms of membrane ion channels and receptors in the modulation of lifespan across multiple species including Caenorhabditis elegans, Drosophila, mouse, and human.
authors.affiliation: Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Kang
authors.affiliation: Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida.|Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida.|Center for Smell and Taste, University of Florida, Gainesville, Florida.|Genetics Institute, University of Florida, Gainesville, Florida.
authors.forename: Rui
authors.initials: R
authors.lastname: Xiao
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D004777:Environment; D006801:Humans; D008136:Longevity; D049990:Membrane Transport Modulators / Q000378:metabolism*; D010641:Phenotype; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D049990:Membrane Transport Modulators; D011956:Receptors, Cell Surface; D020794:Receptor Protein-Tyrosine Kinases
keywords: GPCRs; growth factor receptors; ion channels; lifespan; sensory