title: Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(iii) complexes.
abstract: Herein a series of mitochondria-targeted AIE (aggregation-induced emission)-active Ir(iii) complexes were designed to selectively exert one-/two-photon photodynamic activities in mitochondria to address the issues which current PDT are confronted with (i.e., shallow penetration depth of routinely used irradiation; systematic toxicity associated with effective drug concentration; concentration-quenched photodynamic activity at the target, etc.).
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Liu
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Jin
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Yuan
authors.affiliation: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, P. R. China.
authors.forename: Xingguo
authors.initials: X
authors.lastname: Liu
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Liangnian
authors.initials: L
authors.lastname: Ji
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Hui
authors.identifier: http://orcid.org/0000-0003-4153-5303
authors.initials: H
authors.lastname: Chao