title: Surgically‑induced mouse models in the study of bone regeneration: Current models and future directions (Review).
abstract: Bone regeneration has been extensively studied over the past several decades. The surgically‑induced mouse model is the key animal model for studying bone regeneration, of the various research strategies used. These mouse models mimic the trauma and recovery processes in vivo and serve as carriers for tissue engineering and gene modification to test various therapies or associated genes in bone regeneration. The present review introduces a classification of surgically induced mouse models in bone regeneration, evaluates the application and value of these models and discusses the potential development of further innovations in this field in the future.
authors.affiliation: Department of Orthopedic Surgery, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ning
authors.affiliation: Department of Orthopedic Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Orthopedic Surgery, New York University Medical Center, New York, NY 10003, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Buza
authors.affiliation: Department of Orthopedic Surgery, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Surgery, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
authors.forename: Tanghong
authors.initials: T
authors.lastname: Jia
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D001861:Bone Regeneration; D004195:Disease Models, Animal; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D051379:Mice; D010012:Osteogenesis