title: A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?
abstract: Background. The clinical and histopathologic classification of anetoderma are not well characterized.Objective. We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings.Methods. We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2.Results. Protruding type (n= 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type (n= 13). MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls (p< 0.05). MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue. TIMP-1 was highly expressed in anetoderma lesions and controls. TIMP-2 expression was variable.Conclusions. Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma.
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jung Eun
authors.identifier: 0000-0003-1670-0995
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Ki Min
authors.identifier: 0000-0003-2649-7118
authors.initials: KM
authors.lastname: Sohn
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Young Jun
authors.identifier: 0000-0002-6190-8472
authors.initials: YJ
authors.lastname: Woo
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Kwan Ho
authors.initials: KH
authors.lastname: Jeong
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Miri
authors.identifier: 0000-0001-5167-3449
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jeong Deuk
authors.initials: JD
authors.lastname: Lee
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jun Young
authors.identifier: 0000-0002-8650-1759
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hyun Jeong
authors.identifier: 0000-0002-1555-284X
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Gyong Moon
authors.identifier: 0000-0001-8237-3211
authors.initials: GM
authors.lastname: Kim
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Chul Jong
authors.initials: CJ
authors.lastname: Park
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Yu
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hoon
authors.identifier: 0000-0002-9822-4760
authors.initials: H
authors.lastname: Kang
mesh_terms: D000328:Adult; D057088:Anetoderma / Q000145:classification* / Q000276:immunology / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D018450:Disease Progression; D004549:Elastin / Q000378:metabolism; D005260:Female; D000071838:Fibrillin-1 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D053508:Matrix Metalloproteinase 12 / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D000071838:Fibrillin-1; C560822:TIMP1 protein, human; C560823:TIMP2 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; D004549:Elastin; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C507122:MMP12 protein, human; D053508:Matrix Metalloproteinase 12