title: Evaluation of Oxidative Status in Patients Treated with Electroconvulsive Therapy.
abstract: OBJECTIVE
  Electroconvulsive therapy (ECT) is used in the treatment of many psychiatric diseases and this therapy may be effective on antioxidant defence system. In this study, we aimed to evaluate the effects of ECT on oxidative stress.
  
  
  METHODS
  Fourteen major depression, 11 schizophrenia and 8 bipolar affective disorder patients diagnosed and received ECT treatment, and 37 healthy volunteers enrolled in the study. ECT was applied to all patients. Before ECT, after the first and last ECTs, serum samples were obtained. Serum total antioxidant status (TAS), total oxidant status (TOS), and calculated oxidative stress index (OSI) were measured in patients before and after ECTs.
  
  
  RESULTS
  TOS values before ECT were higher in major depression (p=0.005) and schizophrenia (p=0.001) groups compared to the control group. TAS values were lower in major depression (p=0.0001), schizophrenia (p=0.004), bipolar affective disorder (p=0.004) groups compared to the controls. Also OSI values were higher in major depression (p=0.0001), schizophrenia (p=0.001), bipolar affective disorder (p=0.009) groups compared to healthy group. After the last ECT, TOS values were significantly lower compared to TOS values before ECT in major depression (p=0.004) and schizophrenia patients (p=0.004). TAS values after the first ECT were higher compared to values before ECT in major depression patients (p=0.004). After last ECT, OSI values were significantly lower compared to before ECT in schizophrenia patients (p=0.006).
  
  
  CONCLUSIONS
  As a result, it can be said that ECT did not increase oxidative stress. However, further studies with more patients are needed.
authors.affiliation: Department of Biochemistry, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Şenyurt
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Aybek
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Herken
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kaptanoglu
authors.affiliation: Department of Child and Adolescent Psychiatry, Sivas Numune Hospital, Sivas, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Korkmaz
keywords: Electroconvulsive therapy; Oxidative stress index; Total antioxidant status; Total oxidant status