title: Chitosan cross-linked poly(acrylic acid) hydrogels: Drug release control and mechanism.
abstract: Chitosan has been used to cross-link poly(acrylic acid) to give three pH-sensitive hydrogels designed to control the release of the drugs amoxicillin and meloxicam. The extent of cross-linking and solution pH was found to dominate the swelling behavior of these hydrogels as shown by scanning electron microscopy and swelling time dependencies. The rates of release of amoxicillin and meloxicam from the loaded hydrogels increased with increase in pH consistent with the extent of hydrogen bonding between hydrogel components and between the hydrogel and the drugs being important determinants of release rate. Both the Korsemeyer-Peppas and Weibull models fitted release data consistent with drug release occurred through a combination of drug diffusion and hydrogel relaxation processes. These hydrogels appear to provide an ideal basis for controlled drug delivery systems.
authors.affiliation: State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China; Advanced Soft Matter Group, Department of Chemical Engineering, Delft University of Technology, van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China. Electronic address: jiewang2010@ecust.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China; Stranski-Laboratorium für Physikalische und Theoretische Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, D-10623 Berlin, Germany.
authors.forename: Haoya
authors.initials: H
authors.lastname: Han
authors.affiliation: State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237 Shanghai, China; Engineering Research Center of Materials Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Xinjiang 832000, China. Electronic address: guoxuhong@ecust.edu.cn.
authors.forename: Xuhong
authors.initials: X
authors.lastname: Guo
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011108:Polymers / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; D048271:Chitosan
keywords: Chitosan; Drug delivery; Release mechanism; pH sensitive hydrogel