title: Personalized protein corona on nanoparticles and its clinical implications.
abstract: It is now well understood that once in contact with biological fluids, nanoscale objects lose their original identity and acquire a new biological character, referred to as a protein corona. The protein corona changes many of the physicochemical properties of nanoparticles, including size, surface charge, and aggregation state. These changes, in turn, affect the biological fate of nanoparticles, including their pharmacokinetics, biodistribution, and therapeutic efficacy. It is progressively being accepted that even slight variations in the composition of a protein source (e.g., plasma and serum) can substantially change the composition of the corona formed on the surface of the exact same nanoparticles. Recently it has been shown that the protein corona is strongly affected by the patient's specific disease. Therefore, the same nanomaterial incubated with plasma proteins of patients with different pathologies adsorb protein coronas with different compositions, giving rise to the concept of personalized protein corona. Herein, we review this concept along with recent advances on the topic, with a particular focus on clinical relevance.
authors.affiliation: Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ofarokhzad@bwh.harvard.edu mmahmoudi@bwh.harvard.edu.
authors.forename: Claudia
authors.identifier: http://orcid.org/0000-0001-6468-2571
authors.initials: C
authors.lastname: Corbo
authors.affiliation: Center for Biomimetic Medicine, Houston Methodist Research Institute, Houston, TX, USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Molinaro
authors.affiliation: Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ofarokhzad@bwh.harvard.edu mmahmoudi@bwh.harvard.edu.
authors.forename: Mateen
authors.initials: M
authors.lastname: Tabatabaei
authors.affiliation: Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ofarokhzad@bwh.harvard.edu mmahmoudi@bwh.harvard.edu and King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
authors.affiliation: Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ofarokhzad@bwh.harvard.edu mmahmoudi@bwh.harvard.edu and Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Morteza
authors.identifier: http://orcid.org/0000-0002-2575-9684
authors.initials: M
authors.lastname: Mahmoudi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis*; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D057285:Precision Medicine; D011487:Protein Conformation; D000066970:Protein Corona / Q000032:analysis*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D000066970:Protein Corona