title: Chlorpyrifos induces anxiety-like behavior in offspring rats exposed during pregnancy.
abstract: Chlorpyrifos is a pesticide, member of the organophosphate class, widely used in several countries to manage insect pests on many agricultural crops. Currently, chlorpyrifos health risks are being reevaluated due to possible adverse effects, especially on the central nervous system. The aim of this study was to investigate the possible action of this pesticide on the behaviors related to anxiety and depression of offspring rats exposed during pregnancy. Wistar rats were treated orally with chlorpyrifos (0.01, 0.1, 1 and 10mg/kg/day) on gestational days 14-20. Male offspring behavior was evaluated on post-natal days 21 and 70 by the elevated plus-maze test, open field test and forced swimming test. The results demonstrated that exposure to 0.1, 1 or 10mg/kg/day of chlorpyrifos could induce anxiogenic-like, but not depressive-like behavior at post-natal day 21, without causing fetal toxicity. This effect was reversed on post-natal day 70.
authors.affiliation: Department of Chemistry and Biology, Federal Technological University of Paraná, Curitiba, Paraná 81280-340, Brazil; Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil. Electronic address: jonasgolart@gmail.com.
authors.forename: Jonas G
authors.initials: JG
authors.lastname: Silva
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Boareto
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Anne K
authors.initials: AK
authors.lastname: Schreiber
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Daiany D B
authors.initials: DD
authors.lastname: Redivo
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Eder
authors.initials: E
authors.lastname: Gambeta
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Vergara
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Helen
authors.initials: H
authors.lastname: Morais
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Janaína M
authors.initials: JM
authors.lastname: Zanoveli
authors.affiliation: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Dalsenter
mesh_terms: D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal; D004390:Chlorpyrifos / Q000633:toxicity*; D003863:Depression / Q000523:psychology; D005260:Female; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010575:Pesticides / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D017208:Rats, Wistar
chemical_list: D010575:Pesticides; D004390:Chlorpyrifos
keywords: Anxiety-like behavior; Chlorpyrifos; Fetal toxicity; Pregnancy; Wistar rats