title: [A Case of Familial Adenomatous Polyposis with a Desmoid Tumor Probably Communicating to the Intestinal Lumen That Was Successfully Treated with Non-Surgical Therapy].
abstract: A 44-year-old man with familial adenomatous polyposis underwent laparoscopic-assistedtotal proctocolectomy with ilealpouch anal anastomosis(IPAA). Computed tomography conducted 21 months after IPAA demonstrated bilateral hydronephrosis andan intra-abdominal mass with a maximal diameter of 22 cm, leading to a diagnosis of stage IV desmoid disease, according to the classification by Church and associates. Six courses of combination chemotherapy with doxorubicin plus dacarbazine were administered. Computed tomography after chemotherapy demonstrated marked shrinkage of the desmoidtumor with intraabdominal air andfluidcollection extending just below the skin of the ileostomy closure site. Stoollike fluidoverflowedspontaneously through the site of the ileostomy closure andthe abscess cavity was successfully drained. The patient was discharged 30 days after the start of drainage. The patient is doing well 10 months after the drainage without regrowth of the desmoid tumor, even though a cavity-like lesion encapsulatedby a thick wall remains.
authors.affiliation: Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Chika
authors.forename: Azusa
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ogura
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Amano
authors.forename: Toru
authors.initials: T
authors.lastname: Ishiguro
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuchi
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Eguchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Erito
authors.initials: E
authors.lastname: Mochiki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000188:drug therapy* / Q000235:genetics / Q000628:therapy; D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004322:Drainage; D018222:Desmoid Tumors / Q000188:drug therapy* / Q000235:genetics / Q000628:therapy; D016368:Frameshift Mutation; D006801:Humans; D008297:Male; D010375:Pedigree
chemical_list: C555337:APC protein, human; D025601:Adenomatous Polyposis Coli Protein; D003606:Dacarbazine; D004317:Doxorubicin