title: Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles.
abstract: 1,2,4-Triazoles and 1,3,4-oxadiazoles are prevalent moieties in pharmaceutical agents, yet fused [1,2,4]-triazolo[3,4-b][1,3,4]oxadiazoles are surprisingly under-represented for both synthesis and biological application. We report a rapid, two-step synthesis of [1,2,4]-triazolo[3,4-b][1,3,4]oxadiazoles from commercial 4-amino-1,2,4-triazoles that is highlighted by a microwave accelerated intramolecular cyclization to generate the fused ring system. Our efforts to optimize reaction conditions and elucidate reaction mechanism are also described.
authors.affiliation: Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
authors.forename: Stesphanie L
authors.initials: SL
authors.lastname: Breunig
authors.affiliation: Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Olson
authors.affiliation: Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Harki
keywords: 1,2,4-Triazole; 1,3,4-Oxadiazole; Intramolecular Cyclization; Microwave Chemistry; [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazole