title: Distal-Bond-Selective C-C Activation of Ring-Fused Cyclopentanones: An Efficient Access to Spiroindanones.
abstract: A site-selective rhodium-catalyzed C-C activation of ring-fused cyclopentanones was achieved to afford efficient access to a range of spiroindanones. The use of bulky 2-amino-6-picoline as a cocatalyst is key to the excellent selectivity of this C-C bond cleavage in cyclopentanones.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871, China.|Department of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA.|Department of Chemistry, University of Chicago, Chicago, IL, 60637, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA.|Department of Chemistry, University of Chicago, Chicago, IL, 60637, USA.
authors.forename: Guangbin
authors.identifier: 0000-0003-1331-6015
authors.initials: G
authors.lastname: Dong
mesh_terms: D000586:Amination; D002384:Catalysis; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry*; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D010847:Picolines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003517:Cyclopentanes; D007189:Indans; D010847:Picolines; D013141:Spiro Compounds; C007201:cyclopentanone; D012238:Rhodium
keywords: C−C activation; cyclopentanones; homogeneous catalysis; rhodium; spirocycles