title: Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content.
abstract: BACKGROUND
  The effects of a steroidal antiandrogen (AA) and 5-alpha-reductase inhibitor (5ARI) on prostate tissue hormone content and metabolism are not fully elucidated. The objective of this study is to investigate the hormone content and metabolism of the prostate tissues of patients treated with AA or 5ARI using the ultra-sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.
  
  
  METHODS
  Thirty-nine patients with benign prostatic hyperplasia (BPH) undergoing transurethral surgery were included. Serum and prostate tissue hormone and prostate tissue hormone metabolism analyses were performed using LC-MS/MS after 1 month of treatment with chlormadinone acetate (CMA; steroidal AA, 50 mg/day) or dutasteride (DUTA; dual 5ARI, 0.5 mg/day).
  
  
  RESULTS
  Serum testosterone (T), dihydrotestosterone (DHT), and adrenal androgen levels were lower in the CMA group than the control group. Prostate tissue T and DHT levels were also lower in the CMA group than the control group. In the DUTA group, only serum and prostate DHT concentrations were reduced compared to the control group; in contrast, those of other hormones, especially T and 4-androstene-3,17-dione in the prostate tissue, showed marked elevations up to 70.4- and 11.4-fold normal levels, respectively. Moreover, the hormone metabolism assay confirmed that the conversion of T to DHT was significantly suppressed while that of T to 4-androstene-3,17-dione was significantly accelerated in the prostate tissue of DUTA-treated patients.
  
  
  CONCLUSIONS
  Although treatment with AA and 5ARI show similar clinical outcomes, their effect on tissue hormone content and metabolism varied greatly. Prostate 77: 672-680, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shibata
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Arai
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Miyazawa
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shuto
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Nomura
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sekine
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Koike
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsui
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Ito
authors.affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D002715:Chlormadinone Acetate / Q000494:pharmacology / Q000627:therapeutic use; D000068538:Dutasteride / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D002715:Chlormadinone Acetate; D000068538:Dutasteride
keywords: 5-alpha-reductase inhibitor; benign prostatic hyperplasia; hormone concentration; hormone metabolism; steroidal antiandrogen