title: The Relationship Between Brown Adipose Tissue Content in Supraclavicular Fat Depots and Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus and Prediabetes.
abstract: The evaluation of brown adipose tissue (BAT) and its role in metabolism and obesity remains an important topic in the recent literature. This study evaluated the influence of the BAT triglyceride content measured by proton magnetic resonance (MR) spectroscopy in patients with type 2 diabetes mellitus (DM2) and prediabetes on insulin sensitivity.
  
  
  
  A total of 25 patients with DM2 and prediabetes (45.9 ± 10.1 years old, body mass index [BMI] of 31.6 ± 5.4 kg/m2) underwent anthropometric measurements (BMI), insulin sensitivity analysis (M value during euglycemic hyperinsulinemic clamp and homeostasis model assessment of insulin resistance), proton MR spectroscopy, and blood tests (total cholesterol, low-density lipoproteins, high-density lipoproteins, and triglycerides). The relationship between the triglyceride content in the supraclavicular fat depot and insulin sensitivity, anthropometric measurements, and blood test results was assessed.
  
  
  
  The triglyceride content in the supraclavicular fat depot varied between 79.2% and 97.1% (mean: 92.6% ± 4.2%). The triglyceride content in the subcutaneous white adipose tissue of the neck was significantly higher (85.3%-99.3%; mean: 95.5% ± 2.9%; P = 0.0007). The triglyceride content in the supraclavicular fat depot exhibited a significantly moderate correlation with the BMI (r = 0.64; P = 0.0009). A significant weak negative correlation between the supraclavicular fat content and M value was revealed (r = -0.44; P = 0.002). Patients with high insulin resistance (IR) had a higher triglyceride content in the supraclavicular fat depot than patients with normal and lower IR (94.3% ± 2.0% vs. 90.4% ± 5.2%; P = 0.02).
  
  
  
  Reducing the BAT content in the supraclavicular fat depot can influence the development of IR in patients with DM2 and prediabetes.
authors.affiliation: 1 Endocrinology Research Centre , Moscow, Russia .
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Koksharova
authors.affiliation: 2 Cardiology Research Center , Moscow, Russia .
authors.forename: Dmitry
authors.initials: D
authors.lastname: Ustyuzhanin
authors.affiliation: 1 Endocrinology Research Centre , Moscow, Russia .
authors.forename: Yury
authors.initials: Y
authors.lastname: Philippov
authors.affiliation: 1 Endocrinology Research Centre , Moscow, Russia .|3 I.M. Sechenov First Moscow State Medical University , Moscow, Russia .
authors.forename: Alexander
authors.initials: A
authors.lastname: Mayorov
authors.affiliation: 1 Endocrinology Research Centre , Moscow, Russia .|3 I.M. Sechenov First Moscow State Medical University , Moscow, Russia .
authors.forename: Marina
authors.initials: M
authors.lastname: Shestakova
authors.affiliation: 2 Cardiology Research Center , Moscow, Russia .
authors.forename: Merab
authors.initials: M
authors.lastname: Shariya
authors.affiliation: 3 I.M. Sechenov First Moscow State Medical University , Moscow, Russia .
authors.forename: Sergey
authors.initials: S
authors.lastname: Ternovoy
authors.affiliation: 1 Endocrinology Research Centre , Moscow, Russia .
authors.forename: Ivan
authors.initials: I
authors.lastname: Dedov
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging / Q000378:metabolism*; D000328:Adult; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008074:Lipoproteins / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000000981:diagnostic imaging / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
keywords: Brown adipose tissue; Insulin sensitivity; M value; MR spectroscopy; Type 2 diabetes mellitus; White adipose tissue