title: Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice.
abstract: OBJECTIVE
  Acerola (Malpighia emarginata DC.) is a fruit that is known to contain high amounts of ascorbic acid (AA) and various phytochemicals. We have previously reported that AA deficiency leads to ultraviolet B (UVB)-induced skin pigmentation in senescence marker protein 30 (SMP30)/gluconolactonase (GNL) knockout (KO) hairless mice. The present study was undertaken to investigate the effects of acerola juice (AJ) intake on the skin of UVB-irradiated SMP30/GNL KO mice.
  Five-week old hairless mice were given drinking water containing physiologically sufficient AA (1.5 g/L) [AA (+)], no AA [AA (-)] or 1.67% acerola juice [AJ]. All mice were exposed to UVB irradiation for 6 weeks. UVB irradiation was performed three times per week. The dorsal skin color and stratum corneum water content were measured every weekly, and finally, the AA contents of the skin was determined. The skin AA and stratum corneum water content was similar between the AA (+) and AJ groups. The L* value of the AA (+) group was significantly decreased by UVB irradiation, whereas AJ intake suppressed the decrease in the L* value throughout the experiment. Moreover, in the AJ group, there was a significant decrease in the expression level of dopachrome tautomerase, an enzyme that is involved in melanin biosynthesis.
  
  
  CONCLUSIONS
  These results indicate that AJ intake is effective in suppressing UVB-induced skin pigmentation by inhibiting melanogenesis-related genes.
authors.affiliation: Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Corporate Science Research Division, Nichirei Corporation, Chiba, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Uchida
authors.affiliation: Research and Development Division, Nichirei Foods Corporation, Chiba, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Aoki
authors.affiliation: Research and Development Division, Nichirei Foods Corporation, Chiba, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hanamura
authors.affiliation: Research and Development Division, Research and Development Center, Nichirei Bioscience Corporation, Tokyo, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nagamine
authors.affiliation: Corporate Sponsored Research Program 'Food for Life', The University of Tokyo, Tokyo, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Kato
authors.affiliation: Corporate Science Research Division, Nichirei Corporation, Chiba, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Koizumi
authors.affiliation: Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Akihito
authors.identifier: http://orcid.org/0000-0001-7875-7482
authors.initials: A
authors.lastname: Ishigami
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001834:Body Water / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D015870:Gene Expression; D029581:Malpighiaceae / Q000737:chemistry*; D051379:Mice; D008812:Mice, Hairless; D018345:Mice, Knockout; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D012880:Skin Pigmentation / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D010936:Plant Extracts; D001205:Ascorbic Acid