title: An ultrasensitive electrochemical immunosensor based on the synergistic effect of quaternary Cu2SnZnS4NCs and cyclodextrin-functionalized graphene.
abstract: In this study, highly monodispersed Cu2SnZnS4NCs with a quasi-spherical structure were prepared to construct a sandwich-type electrochemical immunosensor for alpha-fetoprotein detection. Quaternary Cu2SnZnS4NCs as novel biomimetic catalysts show an efficient intrinsic peroxidase-like activity for H2O2reduction. This excellent catalytic activity is ascribed to the higher electroconductivity than those of the binary Cu2S and ternary Cu2SnS3NCs. Moreover, β-cyclodextrin-functionalized graphene sheets are used as substrate materials that can capture large amounts of primary antibodies due to host-guest interaction and high surface area. Under the optimized conditions, the electrochemical immunosensor exhibites a wide working range from 0.5 pg mL-1to 10 ng mL-1and a detection limit of 0.16 pg mL-1at a signal-to-noise ratio of 3. Good sensitivity, reproducibility, and stability demonstrate its potential application in clinical diagnostics.
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, 100083, Beijing, China. zyh@cugb.edu.cn xlyu@cugb.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, 100083, Beijing, China. zyh@cugb.edu.cn xlyu@cugb.edu.cn.
authors.forename: Yihe
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, 100083, Beijing, China. zyh@cugb.edu.cn xlyu@cugb.edu.cn.
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Du
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, 100083, Beijing, China. zyh@cugb.edu.cn xlyu@cugb.edu.cn.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Li
authors.affiliation: Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, 100083, Beijing, China. zyh@cugb.edu.cn xlyu@cugb.edu.cn.
authors.forename: Xuelian
authors.identifier: http://orcid.org/0000-0003-1295-8817
authors.initials: X
authors.lastname: Yu
mesh_terms: D000906:Antibodies / Q000737:chemistry; D015374:Biosensing Techniques; D003300:Copper; D055664:Electrochemical Techniques; D006108:Graphite; D006861:Hydrogen Peroxide; D007118:Immunoassay; D057230:Limit of Detection; D053768:Metal Nanoparticles; D015203:Reproducibility of Results
chemical_list: D000906:Antibodies; D006108:Graphite; D003300:Copper; D006861:Hydrogen Peroxide