title: Enantioselective Addition of Alkynes to α,α-Dichlorinated Aldehydes.
abstract: Enantioselective addition of terminal alkynes to α,α-dichlorinated aldehydes employing Zn(OTf)2/NME is disclosed. The propargylic alcohols obtained are accessed in good yields and high enantioselectivity from easily accessible α,α-dichloroaldehydes. The method opens new strategic opportunities for the synthesis of chlorinated natural products, such as the chlorosulfolipids.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
authors.forename: Yeshua
authors.identifier: 0000-0002-4953-4666
authors.initials: Y
authors.lastname: Sempere Molina
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ruchti
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
authors.forename: Erick M
authors.identifier: 0000-0003-1472-490X
authors.initials: EM
authors.lastname: Carreira