title: Vascular Refilling Is Not Reduced in Dialysis Sessions with Morbid Events.
abstract: BACKGROUND
  It is commonly believed that insufficient vascular refilling leads to hypovolemia during hemodialysis and contributes to intradialytic morbid events (IME). But data of refilling volumes at the time of IME are lacking.
  
  
  METHODS
  We compared the vascular refilling in 10 patients with IME with 14 stable patients with normal blood volume at the dialysis end (66-80 mL/kg).
  
  
  RESULTS
  The refilling characteristics in patients with IME did not differ from those in stable patients. The refilling fraction (refilling/ultrafiltration [UF] ratio) was 73.8 ± 9.4% in patients with IME, and 70.2 ± 6.4% in patients with normal blood volume at the end of the treatment. Refilling volume strongly correlated with UF volume in both patient groups (r2 = 0.93 and r2 = 0.81, respectively).
  
  
  CONCLUSIONS
  IME are associated with a specific blood volume below 65 mL/kg. Vascular refilling is a constant fraction of UF in stable as well as in symptomatic dialysis sessions.
authors.affiliation: Department of Nephrology, Charite Campus Mitte, Universitätsmedizin Berlin, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Kron
authors.forename: Daniel
authors.initials: D
authors.lastname: Schneditz
authors.forename: Til
authors.initials: T
authors.lastname: Leimbach
authors.forename: Sabine
authors.initials: S
authors.lastname: Aign
authors.forename: Joachim
authors.initials: J
authors.lastname: Kron
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D019468:Disease Management; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D020896:Hypovolemia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D006435:Renal Dialysis / Q000009:adverse effects; D014462:Ultrafiltration