title: Alternative Interventions to Prevent Oxidative Damage following Ischemia/Reperfusion.
abstract: Ischemia/reperfusion (I/R) lesions are a phenomenon that occurs in multiple pathological states and results in a series of events that end in irreparable damage that severely affects the recovery and health of patients. The principal therapeutic approaches include preconditioning, postconditioning, and remote ischemic preconditioning, which when used separately do not have a great impact on patient mortality or prognosis. Oxidative stress is known to contribute to the damage caused by I/R; however, there are no pharmacological approaches to limit or prevent this. Here, we explain the relationship between I/R and the oxidative stress process and describe some pharmacological options that may target oxidative stress-states.
authors.affiliation: Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS, Universidad de Guadalajara, Calle Sierra Mojada 950, Colonia Independencia, 44340 Guadalajara, Jal, Mexico.
authors.forename: Simón Quetzalcoatl
authors.initials: SQ
authors.lastname: Rodríguez-Lara
authors.affiliation: Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS, Universidad de Guadalajara, Calle Sierra Mojada 950, Colonia Independencia, 44340 Guadalajara, Jal, Mexico.
authors.forename: Ernesto German
authors.identifier: 0000-0001-7868-667X
authors.initials: EG
authors.lastname: Cardona-Muñoz
authors.affiliation: Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS, Universidad de Guadalajara, Calle Sierra Mojada 950, Colonia Independencia, 44340 Guadalajara, Jal, Mexico.
authors.forename: Ernesto Javier
authors.initials: EJ
authors.lastname: Ramírez-Lizardo
authors.affiliation: Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS, Universidad de Guadalajara, Calle Sierra Mojada 950, Colonia Independencia, 44340 Guadalajara, Jal, Mexico.
authors.forename: Sylvia Elena
authors.initials: SE
authors.lastname: Totsuka-Sutto
authors.affiliation: Laboratorio de Neurofisiología, Departamento de Fisiología, CUCS, Universidad de Guadalajara, Calle Sierra Mojada 950, Colonia Independencia, 44340 Guadalajara, Jal, Mexico.
authors.forename: Araceli
authors.initials: A
authors.lastname: Castillo-Romero
authors.affiliation: Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS, Universidad de Guadalajara, Calle Sierra Mojada 950, Colonia Independencia, 44340 Guadalajara, Jal, Mexico.
authors.forename: Teresa Arcelia
authors.initials: TA
authors.lastname: García-Cobián
authors.affiliation: Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología, CUCS, Universidad de Guadalajara, Calle Sierra Mojada 950, Colonia Independencia, 44340 Guadalajara, Jal, Mexico.
authors.forename: Leonel
authors.identifier: 0000-0001-8087-3597
authors.initials: L
authors.lastname: García-Benavides
mesh_terms: D000818:Animals; D042967:Electron Transport Complex I / Q000378:metabolism; D006801:Humans; D057775:Ischemic Postconditioning; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology*
chemical_list: D042967:Electron Transport Complex I; D010100:Oxygen; D047495:PPAR gamma; D019869:Phosphatidylinositol 3-Kinases