title: Update on Predicting Severe Hyperbilirubinemia and Bilirubin Neurotoxicity Risks in Neonates.
abstract: Extreme hyperbilirubinemia and kernicterus, though rare, continue to occur despite the adoption of universal screening. Unless they are known to have glucose-6-phosphate dehydrogenase deficiency, infants who currently develop kernicterus in high resource countries are often otherwise healthy newborns discharged from the well-baby nursery. In this review, we highlight risk factors that increase the risk of a newborn ≥35 weeks gestational age developing severe hyperbilirubinemia, as well as the risk factors that increase the hyperbilirubinemic infant's risk of kernicterus.
authors.affiliation: Seattle Children's Hospital, M/S FA.2.115, PO Box 5371, Seattle, WA 98145. United States.
authors.forename: Pearl W
authors.initials: PW
authors.lastname: Chang
authors.affiliation: Departments of Epidemiology & Biostatistics and Pediatrics, University of California, San Francisco, CA. United States.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Newman
authors.affiliation: Department of Pediatrics, Beaumont Children's Hospital and Oakland University William Beaumont School of Medicine, Royal Oak, MI. United States.
authors.forename: M Jeffrey
authors.initials: MJ
authors.lastname: Maisels
mesh_terms: D001663:Bilirubin / Q000097:blood*; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications / Q000209:etiology*; D007231:Infant, Newborn; D007647:Kernicterus / Q000209:etiology*; D012307:Risk Factors
chemical_list: D001663:Bilirubin
keywords: Hyperbilirubinemia; jaundice; kernicterus; neonates; neurotoxicity; phototherapy