title: Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy.
abstract: Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.
authors.affiliation: Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology , Beijing 100081, China.
authors.forename: Yanyan
authors.identifier: http://orcid.org/0000-0001-6634-9131
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology , Beijing 100081, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital , Beijing 100853, China.
authors.forename: Qunfang
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital , Beijing 100853, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Xueyun
authors.initials: X
authors.lastname: Gao
authors.affiliation: Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology , Beijing 100081, China.
authors.forename: Yongtian
authors.initials: Y
authors.lastname: Wang
mesh_terms: D006801:Humans; D049329:Nanostructures; D009369:Neoplasms; D010789:Phototherapy; D012834:Silver; D000068936:Theranostic Nanomedicine; D014057:Tomography, X-Ray Computed
chemical_list: D012834:Silver
keywords: X-ray CT imaging; photothermal therapy; protein; renal clearable; silver nanodots