title: Moderate intensity treadmill exercise alters food preference via dopaminergic plasticity of ventral tegmental area-nucleus accumbens in obese mice.
abstract: Obesity has been associated with the excessive intake of palatable food as well as physical inactivity. To investigate the neurobiological mechanism underlying the exercised-induced prevention and treatment of obesity, the present study examined the effect of treadmill exercise on the preference for palatable food in mice. Levels of tyrosine hydroxylase (TH) in the ventral tegmental area-nucleus accumbens system were also analysed, as well as levels of dopamine, dopamine transporter, and D2 receptors in the nucleus accumbens. Forty C57BL/6J mice were randomly divided into a control group (CG, n=10) and a high-fat diet group (HG, N=30). Mice of the HG group were fed a high-fat diet for 12 weeks in order to induce a model of obesity, following which the obese mice were randomly divided into an obese control group (OG, n=11) and an obese+exercise group (OEG, n=12). OEG mice received 8 weeks of treadmill exercise intervention. Our results indicate that, relative to animals in the OG group, OEG mice exhibited significant decreases in the preference for high-fat diets and insulin resistance, along with increases in the preference for sucrose and milk, TH and D2 receptor expression, and levels of dopamine in the ventral tegmental area-nucleus accumbens system. These results suggest that moderate-intensity treadmill exercise can alter food preference in obese mice, which may be mediated by dopaminergic plasticity of the ventral tegmental area-nucleus accumbens and enhanced insulin sensitivity.
authors.affiliation: Department of Physical Education and Health, Hebei Normal University of Science and Technology, West Hebei Street 360, Qinhuangdao, China. Electronic address: tangdh1964@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Physical Education and Health, Hebei Normal University of Science and Technology, West Hebei Street 360, Qinhuangdao, China.
authors.forename: Hai Jun
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Department of Physical Education and Health, Hebei Normal University of Science and Technology, West Hebei Street 360, Qinhuangdao, China.
authors.forename: Ning Ning
authors.initials: NN
authors.lastname: Shang
authors.affiliation: Department of Health and Science, Xi'an Physical Education University,Hanguang Road 65, Xi'an, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Physical Education, Yan shan University, West Hebei Street 438, Qinhuangdao, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Physical Education and Sport, Beijing Normal University,Xinjie Kou Wai Street 19, Beijing, China.
authors.forename: Dong Hui
authors.initials: DH
authors.lastname: Tang
authors.affiliation: Department of Physical Education and Health, Hebei Normal University of Science and Technology, West Hebei Street 360, Qinhuangdao, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
mesh_terms: D000818:Animals; D001835:Body Weight; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D004734:Energy Metabolism; D005518:Food Preferences; D008297:Male; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity; D009714:Nucleus Accumbens / Q000378:metabolism* / Q000503:physiopathology; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology; D010805:Physical Conditioning, Animal; D011954:Receptors, Dopamine / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D017557:Ventral Tegmental Area / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D011954:Receptors, Dopamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine
keywords: Dopamine; Exercise; Obesity; Reward system