title: Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications.
abstract: Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Due to its potential capability of regenerating cartilage, bone, and tendons, autologous adipose SVFs are being tried in treating patients with osteoarthritis (OA), chondromalacia, meniscus tear, osteonecrosis of the femoral head, and tendon injuries. Here, we have reviewed available human clinical studies with regard to patient applications of autologous adipose SVF containing ASCs, specifically assessing effectiveness and safety in the field of orthopedic disorders. All studies reviewed in this article presents potential benefits of autologous adipose SVF in various orthopedic applications without any serious side effects.
authors.affiliation: Stems Medical Clinic, 32-3 Chungdamdong, Gangnamgu, Seoul, 06068, Republic of Korea.|TEDA-Puhua International Hospital, Tianjin, 300457, People's Republic of China.|Life Science Institute, Komplek Permata Senayan, Jalan Tentara Pelajar, Jakarta Selatan, 12210, Indonesia.
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Pak
authors.affiliation: Stems Medical Clinic, 32-3 Chungdamdong, Gangnamgu, Seoul, 06068, Republic of Korea.|National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, Yongin, Gyeonggido, 17058, Republic of Korea.
authors.forename: Jung Hun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, Yongin, Gyeonggido, 17058, Republic of Korea.
authors.forename: Kwang Seung
authors.initials: KS
authors.lastname: Park
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, Yongin, Gyeonggido, 17058, Republic of Korea.|DNA Analysis Division, Seoul institute, National Forensic Service, 139 Jiyangro, Yangcheongu, Seoul, 08036, Republic of Korea.
authors.forename: Moonhee
authors.initials: M
authors.lastname: Park
authors.affiliation: Department of Biological Sciences, Konkuk University, 1 Hwayangdong, Gwangjingu, Seoul, 05029, Republic of Korea. lkang@konkuk.ac.kr.
authors.forename: Lin-Woo
authors.initials: LW
authors.lastname: Kang
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, Yongin, Gyeonggido, 17058, Republic of Korea. sangheelee@mju.ac.kr.
authors.forename: Sang Hee
authors.identifier: http://orcid.org/0000-0002-5660-7122
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D064592:Autografts; D001847:Bone Diseases / Q000628:therapy*; D002356:Cartilage / Q000378:metabolism / Q000473:pathology; D002357:Cartilage Diseases / Q000628:therapy*; D006801:Humans; D017154:Stromal Cells / Q000637:transplantation; D013708:Tendon Injuries / Q000628:therapy*; D013710:Tendons / Q000378:metabolism / Q000473:pathology
keywords: Autologous adipose tissue-derived stem cells; Effectiveness and safety; Mesenchymal stem cell; Orthopedic applications; Stromal vascular fraction