title: Acute kidney injury induces high-sensitivity troponin measurement changes after cardiac surgery.
abstract: The value of cardiac troponin as a risk assessment tool for cardiac disease in the setting of end-stage renal diseases (ESRD) is not equivalent to its value in those with normal renal function. This consideration had not been studied in settings of acute kidney injury (AKI). We aim to explore the diagnostic value of high sensitive troponin T (hsTnT) in the settings of cardiac surgery-induced AKI.
  
  
  
  Single center observational retrospective study. Based on the AKI Network, patients divided into 2 groups, group I without AKI (259 patients) and group II with AKI (100 patients) where serial testing of hsTnT and creatine kinase (CK)-MB were followed in both groups. Patients with (ESRD) were excluded.
  
  
  
  The mean age in our study was 55.1 ± 10.2 years. High association of AKI (27.8%) was found in our patients. Both groups were matched regarding the age, gender, body mass index, the association of diabetes or hypertension, and Euro score. AKI group had significantly higher mortality 5% vs group I 1.1% (p = 0.03). The hsTnt showed a significant sustained rise in the AKI group as compared to the non-AKI group, however CK-MB changes were significant initially but not sustained. The AKI group was more associated with heart failure 17.9% vs 4.9% (p = 0.001); and post-operative atrial fibrillation, 12.4% vs 2.9% (p = 0.005). Lengths of ventilation, stays in ICU and in hospital were significantly higher in the AKI group.
  
  
  
  Unlike the CK-MB profile, the hsTnT showed significant changes between both groups all over the course denoting possible delayed clearance in patients with AKI.
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU, Heart Hospital, Hamad Medical Corporation, Doha, PO 3050, Qatar. a_s_omar@yahoo.com.|Department of Critical Care Medicine, Beni Suef University, Beni Suef, Egypt. a_s_omar@yahoo.com.|Weill Cornell Medical College-Qatar, Doha, Qatar. a_s_omar@yahoo.com.
authors.forename: Amr S
authors.initials: AS
authors.lastname: Omar
authors.affiliation: Weill Cornell Medical College-Qatar, Doha, Qatar.|Department of Nephrology, Hamad Medical Corporation, Doha, PO 3050, Qatar.|Department of Nephrology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: Khaled
authors.initials: K
authors.lastname: Mahmoud
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU, Heart Hospital, Hamad Medical Corporation, Doha, PO 3050, Qatar.|Weill Cornell Medical College-Qatar, Doha, Qatar.|Department of Anesthesia, Al-Azhar University, Cairo, Egypt.
authors.forename: Samy
authors.initials: S
authors.lastname: Hanoura
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU, Heart Hospital, Hamad Medical Corporation, Doha, PO 3050, Qatar.|Department of Anesthesia, Al-Azhar University, Cairo, Egypt.
authors.forename: Hany
authors.initials: H
authors.lastname: Osman
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU, Heart Hospital, Hamad Medical Corporation, Doha, PO 3050, Qatar.
authors.forename: Praveen
authors.initials: P
authors.lastname: Sivadasan
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU, Heart Hospital, Hamad Medical Corporation, Doha, PO 3050, Qatar.
authors.forename: Suraj
authors.initials: S
authors.lastname: Sudarsanan
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU, Heart Hospital, Hamad Medical Corporation, Doha, PO 3050, Qatar.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Shouman
authors.affiliation: Department of Cardiology Research Center, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Rajvir
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU, Heart Hospital, Hamad Medical Corporation, Doha, PO 3050, Qatar.
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: AlKhulaifi
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012189:Retrospective Studies; D018570:Risk Assessment; D020107:Troponin T / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D020107:Troponin T
keywords: Acute kidney injury; Cardiac surgery; High sensitive troponin