title: It's a long way to the top (if you want to personalize immunotherapy).
abstract: Harnessing the immune system to attack tumor cells by targeting tumor-associated or -preferably- tumor-specific antigens has emerged as a promising but challenging treatment option for malignant lymphomas. Follicular lymphoma is among the most common lymphomas worldwide and remains incurable for most patients. Considered to be an immunogenic disease it represents an interesting disease entity for various immunotherapeutic approaches. In an article published in the May issue ofClinical Cancer Research, Nielsen and colleagues provided important proof-of-principle data on the immunogenicity of follicular lymphoma that might represent a first step towards personalized adoptive immunotherapies in this disease. The authors combined targeted next-generation sequencing and in silico analyses to explore the concept of somatic neoepitope prediction. Neoantigen-specific CD8+T-cells could be identified in a small subset of patients selected for in vitro immunogenicity experiments, however at remarkably low frequencies and in only a few patients at single time-points. Of note, the immunogenic neoepitopes were derived from mutantCREBBPandMEF2B, two genes that have previously been shown to be functionally and prognostically relevant in this disease. In this commentary we discuss the promises but also the challenges of how to translate these findings into clinical practice.
authors.affiliation: Department of Medicine III, Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Ludwig-Maximilians-University, Max-Lebsche Platz 30, 81377 Munich, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Haebe
authors.affiliation: Department of Medicine III, Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Ludwig-Maximilians-University, Max-Lebsche Platz 30, 81377 Munich, Germany ; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Weigert
mesh_terms: D000939:Epitopes / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D057285:Precision Medicine; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000939:Epitopes
keywords: Follicular lymphoma; Immunotherapy; Neoepitope; Somatic mutation