title: Fibroblast Growth Factor 23-Mediated Bone Disease.
abstract: Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Anda R
authors.initials: AR
authors.lastname: Gonciulea
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: sjandebe@jhmi.edu.
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Jan De Beur
mesh_terms: D001847:Bone Diseases / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D000090265:Klotho Proteins; D010710:Phosphates / Q000378:metabolism; D015398:Signal Transduction; D014807:Vitamin D / Q000378:metabolism
chemical_list: C000717427:FGF23 protein, human; D010710:Phosphates; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: FGF23; Hyperphosphatemia; Hypophosphatemia; Osteomalacia; Rickets; α-Klotho