title: Targeting a metabolic pathway to fight the flu.
abstract: Our antiviral arsenal to fight influenza viruses is limited and we need novel anti-flu drugs. Recently, cellular drug targets came into focus and omics analysis were instrumental to suggest candidate factors. In this issue of The FEBS Journal, Kainov and colleagues used transcriptome data to investigate virus-induced changes in tryptophan metabolism that may serve as immunomodulatory approach against viruses.
authors.affiliation: Institute of Virology (IVM), Westfaelische-Wilhelms University, Muenster, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Boergeling
authors.affiliation: Institute of Virology (IVM), Westfaelische-Wilhelms University, Muenster, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Ludwig
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000235:genetics / Q000276:immunology; D007251:Influenza, Human / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000821:virology; D007372:Interferons / Q000235:genetics / Q000276:immunology; D007737:Kynurenine / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects / Q000821:virology; D053858:Metabolic Networks and Pathways / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D009975:Orthomyxoviridae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D059467:Transcriptome; D014364:Tryptophan / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; C576710:IDO1 protein, human; D007155:Immunologic Factors; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007737:Kynurenine; D014364:Tryptophan; D007372:Interferons