title: Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling.
abstract: Oxygen is a central molecule in the development of multicellular life, allowing efficient energy generation. Inadequate oxygen supply requires rapid adaptations to prevent cellular damage and the hypoxia-inducible factor (HIF) pathway plays a central role in this adaptation. Numerous diseases and disease processes are influenced by hypoxia and the HIF pathway. One component, von Hippel Lindau (VHL), is a well-known tumor suppressor, which acts at least in part via regulating HIF signaling. The zebrafish has become a central vertebrate model organism in which developmental and disease processes can be studied. In this review, we have tried to bring together knowledge on the HIF/hypoxic signaling pathway in zebrafish, including what is known on VHL functions.
authors.affiliation: University of Sheffield, Sheffield, United Kingdom.
authors.forename: H R
authors.initials: HR
authors.lastname: Kim
authors.affiliation: University of Sheffield, Sheffield, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Greenald
authors.affiliation: Università degli Studi di Padova, Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Vettori
authors.affiliation: University of Sheffield, Sheffield, United Kingdom.
authors.forename: E
authors.initials: E
authors.lastname: Markham
authors.affiliation: SRM University, Kattankulathur, India.
authors.forename: K
authors.initials: K
authors.lastname: Santhakumar
authors.affiliation: Università degli Studi di Padova, Padova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Argenton
authors.affiliation: University of Sheffield, Sheffield, United Kingdom.
authors.forename: F
authors.initials: F
authors.lastname: van Eeden
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics*; D010100:Oxygen / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism; D015027:Zebrafish / Q000235:genetics; D029961:Zebrafish Proteins / Q000235:genetics*; D006623:von Hippel-Lindau Disease / Q000235:genetics* / Q000473:pathology
chemical_list: D051793:Hypoxia-Inducible Factor 1; D025521:Tumor Suppressor Proteins; C542158:Vhl protein, zebrafish; D029961:Zebrafish Proteins; D010100:Oxygen
keywords: Angiogenesis; Cancer; Circadian clock; HIF reporter; Hypoxia; Hypoxia responsive element; Hypoxia-inducible factor; Metabolism; Oxygen; Polycythemia; Prolyl hydroxylase; Zebrafish; von Hippel Lindau