title: Hyperuricaemia, Xanthine Oxidoreductase and Ribosome-Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research.
abstract: The enzymes called ribosome-inactivating proteins (RIPs) that are able to depurinate  nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline  research field, mostly because of their promising medical applications. The contributions of Stirpe  to the development of these studies has been one of the most relevant. After a short biographical  introduction, an overview is offered of the main results obtained by his investigations during last  55 years on his main research lines: hyperuricaemia, xanthine oxidoreductase and RIPs.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. andrea.bolognesi@unibo.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bolognesi
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. massimo.bortolotti2@unibo.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bortolotti
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. mariagiulia.battelli@unibo.it.
authors.forename: Maria Giulia
authors.initials: MG
authors.lastname: Battelli
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. letizia.polito@unibo.it.
authors.forename: Letizia
authors.initials: L
authors.lastname: Polito
mesh_terms: D000818:Animals; D005197:Famous Persons; D005632:Fructose / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D033461:Hyperuricemia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D007558:Italy; D010940:Plant Proteins / Q000494:pharmacology*; D012106:Research / Q000266:history; D054788:Ribosome Inactivating Proteins / Q000494:pharmacology*; D012276:Ricin / Q000494:pharmacology; D057170:Translational Research, Biomedical / Q000266:history; D014968:Xanthine Dehydrogenase / Q000378:metabolism*
chemical_list: D010940:Plant Proteins; D005632:Fructose; D012276:Ricin; D014968:Xanthine Dehydrogenase; D054788:Ribosome Inactivating Proteins
keywords: gout;   xanthine oxidoreductase;  hyperuricaemia;  immunotoxins;  ribosome‐inactivating proteins;  ricin;  toxic lectins