title: IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity.
abstract: The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism.
authors.affiliation: Academy of Scientific & Innovative Research (AcSIR), New Delhi, India; PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J&K, India.
authors.forename: Amarinder
authors.initials: A
authors.lastname: Singh
authors.affiliation: Deptt. of Pathology, Govt. Medical College, Jammu 180001, J&K, India.
authors.forename: S
authors.initials: S
authors.lastname: Arvinda
authors.affiliation: PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J&K, India.
authors.forename: Surjeet
authors.initials: S
authors.lastname: Singh
authors.affiliation: Deptt. of Pathology, Govt. Medical College, Jammu 180001, J&K, India.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Suri
authors.affiliation: Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J&K, India.
authors.forename: Surinder
authors.initials: S
authors.lastname: Koul
authors.affiliation: Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J&K, India.
authors.forename: Dilip M
authors.initials: DM
authors.lastname: Mondhe
authors.affiliation: PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J&K, India. Electronic address: singh_gd@iiim.ac.in.
authors.forename: Gurdarshan
authors.initials: G
authors.lastname: Singh
authors.affiliation: Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J&K, India.
authors.forename: Ram
authors.initials: R
authors.lastname: Vishwakarma
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D029743:Boswellia; D002945:Cisplatin / Q000633:toxicity*; D018360:Crystallography, X-Ray; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology; D011897:Random Allocation; D013076:Sperm Count / Q000379:methods; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D020011:Protective Agents; D014315:Triterpenes; C054625:boswellic acid; D002945:Cisplatin; C013330:uvaol
keywords: Cisplatin; Histopathology; Oxidative stress; Sperm motility; Urogenital