title: The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer.
abstract: Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several single-nucleotide polymorphisms inmicroRNAgenes that are associated with the susceptibility of biliary tract tumors.
authors.affiliation: Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Nina Nayara
authors.initials: NN
authors.lastname: Ferreira Martins
authors.affiliation: Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Kelly Cristina
authors.initials: KC
authors.lastname: da Silva Oliveira
authors.affiliation: Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Amanda
authors.initials: A
authors.lastname: Braga Bona
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Marília
authors.initials: M
authors.lastname: de Arruda Cardoso Smith
authors.affiliation: Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Geraldo
authors.initials: G
authors.lastname: Ishak
authors.affiliation: Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Paulo Pimentel
authors.initials: PP
authors.lastname: Assumpção
authors.affiliation: Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Rommel Rodríguez
authors.initials: RR
authors.lastname: Burbano
authors.affiliation: Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Danielle Queiroz
authors.identifier: 0000-0002-4429-2573
authors.initials: DQ
authors.lastname: Calcagno