title: Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections.
abstract: Healthcare-associated infections (HAIs) are the infections that patients get while receiving medical treatment in a medical facility with bacterial HAIs being the most common. Silver and gold nanoparticles (NPs) have been successfully employed as antibacterial motifs; however, NPs leaching in addition to poor dispersion and overall reproducibility are major hurdles to further product development. In this study, the authors design and fabricate a smart antibacterial mixed-matrix membrane coating comprising colloidal lysozyme-templated gold nanoclusters as nanofillers in poly(ethylene oxide)/poly(butylene terephthalate) amphiphilic polymer matrix. Mesoporous silica nanoparticles-lysozyme functionalized gold nanoclusters disperse homogenously within the polymer matrix with no phase separation and zero NPs leaching. This mixed-matrix coating can successfully sense and inhibit bacterial contamination via a controlled release mechanism that is only triggered by bacteria. The system is coated on a common radiographic dental imaging device (photostimulable phosphor plate) that is prone to oral bacteria contamination. Variation and eventually disappearance of the red fluorescence surface under UV light signals bacterial infection. Kanamycin, an antimicrobial agent, is controllably released to instantly inhibit bacterial growth. Interestingly, the quality of the images obtained with these coated surfaces is the same as uncoated surfaces and thus the safe application of such smart coatings can be expanded to include other medical devices without compromising their utility.
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Shahad K
authors.initials: SK
authors.lastname: Alsaiari
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Hammami
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Jonas G
authors.initials: JG
authors.lastname: Croissant
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Haneen W
authors.initials: HW
authors.lastname: Omar
authors.affiliation: Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Neelakanda
authors.affiliation: Analytical Core Lab, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Tahir
authors.initials: T
authors.lastname: Yapici
authors.affiliation: Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Klaus-Viktor
authors.initials: KV
authors.lastname: Peinemann
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Niveen M
authors.initials: NM
authors.lastname: Khashab
mesh_terms: D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D017979:Gold Colloid / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007612:Kanamycin / Q000737:chemistry / Q000494:pharmacology; D061986:MCF-7 Cells; D009113:Muramidase / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology
chemical_list: D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D017979:Gold Colloid; D007612:Kanamycin; D012822:Silicon Dioxide; D009113:Muramidase
keywords: antibacterial surfaces; controlled release; gold nanoclusters; mesoporous silica nanoparticles; mixed matrix membranes