title: Successful Treatment of Human Plague with Oral Ciprofloxacin.
abstract: The US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.
authors.forename: Titus
authors.initials: T
authors.lastname: Apangu
authors.forename: Kevin
authors.initials: K
authors.lastname: Griffith
authors.forename: Janet
authors.initials: J
authors.lastname: Abaru
authors.forename: Gordian
authors.initials: G
authors.lastname: Candini
authors.forename: Harriet
authors.initials: H
authors.lastname: Apio
authors.forename: Felix
authors.initials: F
authors.lastname: Okoth
authors.forename: Robert
authors.initials: R
authors.lastname: Okello
authors.forename: John
authors.initials: J
authors.lastname: Kaggwa
authors.forename: Sarah
authors.initials: S
authors.lastname: Acayo
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Ezama
authors.forename: Brook
authors.initials: B
authors.lastname: Yockey
authors.forename: Christopher
authors.initials: C
authors.lastname: Sexton
authors.forename: Martin
authors.initials: M
authors.lastname: Schriefer
authors.forename: Edward Katongole
authors.initials: EK
authors.lastname: Mbidde
authors.forename: Paul
authors.initials: P
authors.lastname: Mead
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010930:Plague / Q000188:drug therapy* / Q000453:epidemiology; D014454:Uganda / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin
keywords: FDA approval; Yersinia pestis; bacteria; bacterial infection; ciprofloxacin; human; infectious diseases; plague; treatment; vector-borne infections; zoonoses