title: A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report.
abstract: The purpose of this review is to provide comprehensive and relevant information on the utilization and pharmacological activities of Strychnos nux-vomica Linn. (Loganiaceae), used for the treatment of various diseases. Strychnos nux-vomica is an evergreen tree native to Southeast Asia and its dried seeds are used for the treatment of neurodisorders, arthritis and vomiting. The different use of this plant as herbal remedy in Chinese medicine is also reported in the literature. Strychnine and brucine are major pharmacologically active phytoconstituents of Strychnos nux-vomica, which are central nervous stimulant, but also found to be poisonous at high dosage. Owing to its diversity of phytoconstituents, it is used for treatment of various disorders. Pharmacologically it has been validated for its effect on inflammation, microbial infections, gastrointestinal problem, nervous system, bones cells, cardiovascular systems, cancer and blood glucose level. It also has antioxidant activity and antifeedant activity. Informations about Strychnos nux-vomica, compiled in the present review article could be useful to the researchers for the scientific validation of its traditional claim in the future.
authors.affiliation: GLA Institute of Pharmaceutical Research, Mathura, 281406, India.
authors.forename: Kanika
authors.initials: K
authors.lastname: Patel
authors.affiliation: Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, India.
authors.forename: Damiki
authors.initials: D
authors.lastname: Laloo
authors.affiliation: Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, India.
authors.forename: Gireesh Kumar
authors.initials: GK
authors.lastname: Singh
authors.affiliation: Sri Kakatiya Institute of Pharmaceutical Sciences, Warangal, 506004, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Gadewar
authors.affiliation: Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, India. dkpatel.rs.phe@itbhu.ac.in.|Department of Pharmacy, Galgotias University, Greater Noida, 203201, Uttar Pradesh, India. dkpatel.rs.phe@itbhu.ac.in.
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Patel
keywords: Strychnos nux-vomica; analytical technique; herbal medicine; pharmacological activity; phytochemistry