title: Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion.
abstract: A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integration sites revealed a clonal disease, distinct from the first tumor.
authors.affiliation: Département d'Immunologie Clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), 1 avenue Claude Vellefaux, 75010, Paris, France. eric.oksenhendler@aphp.fr.|EA3518, Université Paris Diderot Paris 7, Paris, France. eric.oksenhendler@aphp.fr.
authors.forename: Eric
authors.identifier: http://orcid.org/0000-0001-8588-7138
authors.initials: E
authors.lastname: Oksenhendler
authors.affiliation: Section of Virology, Division of Infectious Diseases, Imperial College, London, W2 1PG, UK.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Turpin
authors.affiliation: Département d'Immunologie Clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), 1 avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Lhote
authors.affiliation: Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, 75015, Paris, France.|CNRS, UMR3569, 75015, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Cassar
authors.affiliation: Laboratoire d'Hématologie, Université Paris-Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, EA3518, Hôpital Saint-Louis, AP-HP, Paris, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Cayuela
authors.affiliation: Département d'Immunologie Clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), 1 avenue Claude Vellefaux, 75010, Paris, France.|Inserm U1126, Centre Hayem, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Fieschi
authors.affiliation: Département d'Immunologie Clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), 1 avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Galicier
authors.affiliation: Department of Pathology, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), Paris, France.
authors.forename: Veronique
authors.initials: V
authors.lastname: Meignin
authors.affiliation: Section of Virology, Division of Infectious Diseases, Imperial College, London, W2 1PG, UK.
authors.forename: Charles
authors.initials: C
authors.lastname: Bangham
authors.affiliation: Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, 75015, Paris, France.|CNRS, UMR3569, 75015, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Gessain
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D015368:Human T-lymphotropic virus 1; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011247:Pregnancy; D012074:Remission Induction
keywords: Adult T-cell leukemia/lymphoma; HTLV-1; Transfusion