title: Analysis of serum corticosteroid-induced alkaline phosphatase isoenzyme in dogs with hepatobiliary diseases.
abstract: OBJECTIVE
  To reveal the relationship between canine corticosteroid-induced alkaline phosphatase isoenzyme activity and hepatobiliary diseases.
  
  
  METHODS
  Retrospective analysis of the relationship between serum corticosteroid-induced alkaline phosphatase activity and diagnosis, serum cortisol concentration and alanine transferase activity in dogs with hepatobiliary diseases. Dogs with a history of glucocorticoid administration were excluded.
  
  
  RESULTS
  Seventy-two dogs with hepatobiliary diseases were analysed. The serum corticosteroid-induced alkaline phosphatase concentration was increased in dogs with hepatobiliary diseases. There was no correlation between serum cortisol concentration and serum corticosteroid-induced alkaline phosphatase percentage or activity.
  
  
  CONCLUSIONS
  Dogs with hepatobiliary disease can exhibit high serum alkaline phosphatase activity even if the dogs have not been administrated glucocorticoids and the serum cortisol concentration is normal.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kanemoto
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Goto-Koshino
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007527:Isoenzymes; D008107:Liver Diseases / Q000097:blood / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D001647:Bile Acids and Salts; D007527:Isoenzymes; D000469:Alkaline Phosphatase