title: Clinical and prognostic analysis of 78 patients with human immuno-deficiency virus associated non-Hodgkin's lymphoma in Chinese population.
abstract: BACKGROUND
  Human Immuno-deficiency Virus (HIV) associated non-Hodgkin's lymphoma (NHL) was a special group of disease, which manifests distinct clinical features and prognosis as compared with NHLs in patients without HIV. We performed this study to describe the clinical features of the disease and investigated the potential prognostic factors.
  
  
  METHODS
  HIV-infected patients who were newly diagnosed with NHL were enrolled in this study. The selection of anti-lymphoma treatment regimen was mainly dependent on the pathological subtypes of NHLs. Tumor response was reviewed and classified according to the International Workshop Criteria.
  
  
  RESULTS
  A total of 78 patients were enrolled, among whom, 42 (53.8%) were with Diffuse large B cell Lymphoma (DLBCL), and 29 (37.2%) were with Burkitt lymphoma (BL). BL patients presented with higher risk features as compared with DLBCL in terms of numbers of extranodal diseases (P= 0.004) and poor Eastern cooperative oncology group (ECOG) score (P= 0.038). The estimated 2-year overall survival (OS) and progression free survival (PFS) rate was 74.3 ± 8.1%, 28.9 ± 11.0%, and 54.2 ± 8.1%, 19.2 ± 7.5% for DLBCL and BL, respectively. In multivariate analysis, international prognostic index (IPI) score was an independent prognostic factor for predicting both OS (OR = 2.172, 95% CI 1.579-2.987,P< 0.001) and PFS (OR = 1.838, 95% CI 1.406-2.402,P< 0.001).
  
  
  CONCLUSIONS
  HIV associated NHLs represents a group of heterogeneous aggressive diseases with poor prognosis. IPI parameters were still effective in predicting the prognosis of HIV associated NHLs.
authors.affiliation: Department of Hematology, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200000 China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Renfang
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Yinzhong
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Tangkai
authors.initials: T
authors.lastname: Qi
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Liqian
authors.initials: L
authors.lastname: Guan
authors.affiliation: Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508 China.
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Lu
keywords: Human immuno-deficiency virus; International prognostic index; Lymphoma; Prognosis