title: Endovenous laser ablation in patients with severe primary chronic venous insufficiency.
abstract: BACKGROUND
  The aim of study was to estimate the safety and efficacy of using laser wavelength of 1560 nm with the foam sclerotherapy (FS) of varicose veins (VVs) for the treatment of severe primary chronic venous insufficiency (CVI, C4-C6) in patients with different diameters of the proximal segment (DPS) of the great saphenous vein (GSV).
  
  
  METHODS
  We have separated the patients into two groups depending on the size of GSV: group 1 (281 cases; DPS of GSV less than 15 mm) and group 2 (210 cases; DPS of GSV more than 15 mm). Both groups received the endovenous laser ablation (EVLA) of the saphenous vein trunk, incompetent perforator veins (IPs) and FS (Tessari method) of VVs. The linear endovenous energy density (LEED) was personalized depending on the vein size.
  
  
  RESULTS
  The healing of ulcers and resolution of venous eczema in 6 months were considered the primary end-point. Healing of ulcers was found in 45/55 (82%) cases in group 1 and in 31/35 (88%) cases in group 2. The resolution of venous eczema in 56 (80%) from 70 cases in group 1 and 45 (85%) from 53 cases in group 2 was observed. Leg ulcer recurrence at 3 years' follow-up in 7.3% cases in group 1 and 8.6% cases in group 2 was determined.
  
  
  CONCLUSIONS
  Our experience of using laser wavelength of 1560 nm and FS of VVs for the treatment of severe primary CVI shows the safety and efficacy of this technique in patients with different DPS of GSV.
authors.affiliation: Novosibirsk State Budget Research Institute of Circulation Pathology, Ministry for Public Healthcare of the Russian Federation, Novosibirsk, Russia - starodub@mail.ru.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Starodubtsev
authors.affiliation: Novosibirsk State Budget Research Institute of Circulation Pathology, Ministry for Public Healthcare of the Russian Federation, Novosibirsk, Russia.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Lukyanenko
authors.affiliation: Novosibirsk State Budget Research Institute of Circulation Pathology, Ministry for Public Healthcare of the Russian Federation, Novosibirsk, Russia.
authors.forename: Andrey
authors.initials: A
authors.lastname: Karpenko
authors.affiliation: Novosibirsk State Budget Research Institute of Circulation Pathology, Ministry for Public Healthcare of the Russian Federation, Novosibirsk, Russia.
authors.forename: Pavel
authors.initials: P
authors.lastname: Ignatenko
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003131:Combined Modality Therapy; D057510:Endovascular Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012501:Saphenous Vein / Q000503:physiopathology / Q000601:surgery*; D012597:Sclerosing Solutions / Q000008:administration & dosage; D015911:Sclerotherapy; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014648:Varicose Veins / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D014689:Venous Insufficiency / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D014945:Wound Healing
chemical_list: D012597:Sclerosing Solutions