title: Impact of Aberrant Antigens in the Outcome of Patients with Acute Leukemia at a Referral Institution in Mexico City.
abstract: BACKGROUND
  Patients with acute leukemia can express aberrant markers, defined as antigens that are normally restricted to a different lineage. The reported significance and frequency of these markers is inconclusive. We assessed the frequency and impact of aberrant markers in patients with acute leukemia in a referral institution in Mexico City.
  
  
  METHODS
  We included 433 patients, diagnosed and treated between 2005 and 2015 in our institution.
  
  
  RESULTS
  Aberrant markers were expressed in 128 patients (29.6%); CD13 and CD33 were the most frequent aberrant markers in patients with acute lymphoblastic leukemia, while CD7 and CD19 were the most frequent in patients with acute myeloid leukemia. In the univariate analysis, the group with aberrant markers had a lower disease-free survival when compared with the aberrant-free group (8 vs. 13 months) (p = 0.03). Aberrant expression of CD10, CD20, and CD33 correlated with a worse outcome in a statistically significant manner. In the multivariate analysis, male gender, lymphoid lineage, secondary leukemia, high risk at diagnosis, and the presence of aberrant markers had a significantly negative impact on disease-free survival.
  
  
  CONCLUSIONS
  The use of more aggressive treatment strategies could be considered in patients with acute leukemia and an aberrant expression of CD10, CD20, and CD33.
authors.affiliation: Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.|Faculty of Health Sciences, Universidad Anáhuac México Norte, Huixquilucan, Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rodríguez-Rodríguez
authors.affiliation: Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.|Faculty of Health Sciences, Universidad Anáhuac México Norte, Huixquilucan, Mexico.
authors.forename: Alan
authors.initials: A
authors.lastname: Pomerantz
authors.affiliation: Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: Roberta
authors.initials: R
authors.lastname: Demichelis-Gómez
authors.affiliation: Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: Georgina
authors.initials: G
authors.lastname: Barrera-Lumbreras
authors.affiliation: Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Barrales-Benítez
authors.affiliation: Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: Xavier
authors.initials: X
authors.lastname: Lopez-Karpovitch
authors.affiliation: Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Aguayo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000097:blood*; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015456:Leukemia, Biphenotypic, Acute / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D015999:Multivariate Analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor