title: In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb.
abstract: The present study aimed to investigate the role of several biologically active compounds fromFumaria schleicheriSoy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from theFumaria schleicheriherb and studied along withFumaria schleicheridry extract in mice with pentylenetetrazole-induced seizures. According to empirical results, the expressed anticonvulsant effect ofFumaria schleicheridry extract depends on the synergism of biologically active compounds in herbal medicine, although some individual substances (mostly protopine and the protein-polysaccharide fraction) have shown moderate anti-seizure activity.
authors.affiliation: Department of Drugs Quality, Standardization and Certification, Institute of Pharmacy Professionals Qualification Improvement, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine. yuliya.prok@gmail.com.
authors.forename: Yuliya
authors.initials: Y
authors.lastname: Prokopenko
authors.affiliation: Department of Pharmacology, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine. tsyvunin-vad@ukr.net.
authors.forename: Vadim
authors.initials: V
authors.lastname: Tsyvunin
authors.affiliation: Department of Pharmacology, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine. shtrygol@mail.ru.
authors.forename: Sergey
authors.initials: S
authors.lastname: Shtrygol'
authors.affiliation: Department of Pharmaceutical Chemistry, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine. vgeor@ukr.net.
authors.forename: Victoriya
authors.initials: V
authors.lastname: Georgiyants
keywords: Fumaria schleicheri; alkaloid fraction; anticonvulsant activity; flavonoid fraction; protein-polysaccharide fraction; protopine