title: Fabrication of Antibacterial and Antiwear Hydroxyapatite Coatings via In Situ Chitosan-Mediated Pulse Electrochemical Deposition.
abstract: Although bioinert titanium has been widely applied in orthopedics and related fields, its usage is limited by its unsatisfying osteoinductivity, anti-infection capability, and wear-resistance. Osteoinductive apatite coating can be fabricated on a titanium surface by electrochemical methods, but this causes bacterial adhesion and poor wear-resistance. On the basis of pulse electrochemical technology, a wear-resistance and antibacterial osteoinductive coating was fabricated through codeposition of hydroxyapatite (HA) and nano-Ag effectuated by the cohybridization ofchitosan (CS) with Ag+and Ca2+. A composite coating formed with uniformly dispersed spherical nanoparticles was obtained at optimized deposition potential, Ag concentration, and apatite concentration. The nanocomposite coating shows excellent bioinductive activity; it promotes preferential growth on the (002) face, and needle-like ordered arrangement of apatite. Due to the mediation of CS hybridization, a compact structure is achieved in the HA/Ag composite coating which significantly enhances the wear-resistance of the coating and reduces the release of Ca2+and Ag+. The antibacterial rate of the coating on Escherichia coli and Staphylococcus aureus is up to 99% according to the antibacterial test. In conclusion, a wear-resistant and long-term antibacterial bioactive nanocomposite coating is successfully fabricated on titanium surface through the strategy established in this study.
authors.affiliation: College of Chemical Engineering, Xinjiang Normal University , Urumqi, 830054, Xinjiang China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University , 708 Renmin Road, Suzhou, Jiangsu 215006, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University , 708 Renmin Road, Suzhou, Jiangsu 215006, P.R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yu
authors.affiliation: College of Chemical Engineering, Xinjiang Normal University , Urumqi, 830054, Xinjiang China.
authors.forename: Yingbo
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University , 708 Renmin Road, Suzhou, Jiangsu 215006, P.R. China.
authors.forename: Wenguo
authors.identifier: http://orcid.org/0000-0002-6938-9582
authors.initials: W
authors.lastname: Cui
keywords: antibacteria; composite coating; frictional wear; hydroxyapatite; pulse electrochemical deposition