title: Copper-Catalyzed Asymmetric Borylation: Construction of a Stereogenic Carbon Center Bearing Both CF3and Organoboron Functional Groups.
abstract: Copper-catalyzed borylation of β-trifluoromethyl-α,β-unsaturated ketones was efficiently achieved by means of bis(pinacolato)diboron (B2pin2), affording the enantioenriched products in good yields with high enantioselectivities. CuI and (R,S)-Josiphos consist of the most efficient catalyst system under mild conditions. In the absence of the chiral ligand, the reactions could be performed more efficiently to form β-ketone derivatives which were directly borylated and indirectly trifluoromethylated at the β-carbon atom of the α,β-unsaturated ketone substrates. The present protocol provides a promising method to access a stereogenic carbon center bearing both CF3and organoboron functional groups.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, People's Republic of China.
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, People's Republic of China.
authors.forename: Tenglong
authors.initials: T
authors.lastname: Guo
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, People's Republic of China.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 354 Fenglin Road, Shanghai 200032, People's Republic of China.
authors.forename: Zhengkun
authors.identifier: 0000-0002-9908-0017
authors.initials: Z
authors.lastname: Yu