title: The reliability of Cavalier's principle of stereological method in determining volumes of enchondromas using the computerized tomography tools.
abstract: Volumetric measurements of benign tumors enable surgeons to trace volume changes during follow-up periods. For a volumetric measurement technique to be applicable, it should be easy, rapid, and inexpensive and should carry a high interobserver reliability. We aimed to assess the interobserver reliability of a volumetric measurement technique using the Cavalier's principle of stereological methods.
  
  
  
  The computerized tomography (CT) of 15 patients with a histopathologically confirmed diagnosis of enchondroma with variant tumor sizes and localizations was retrospectively reviewed for interobserver reliability evaluation of the volumetric stereological measurement with the Cavalier's principle, V = t × [((SU) × d) /SL]2 × Σ P.
  
  
  
  The volumes of the 15 tumors collected by the observers are demonstrated in Table 1. There was no statistical significance between the first and second observers ( p = 0.000 and intraclass correlation coefficient = 0.970) and between the first and third observers ( p = 0.000 and intraclass correlation coefficient = 0.981). No statistical significance was detected between the second and third observers ( p = 0.000 and intraclass correlation coefficient = 0.976).
  
  
  
  The Cavalier's principle with the stereological technique using the CT scans is an easy, rapid, and inexpensive technique in volumetric evaluation of enchondromas with a trustable interobserver reliability.
authors.affiliation: 1 Department of Orthopaedics and Traumatology, Catalca ilyas cokay Hospital, Catalca, Istanbul, Turkey.
authors.forename: Nihat
authors.initials: N
authors.lastname: Acar
authors.affiliation: 2 Department of Orthopaedics and Traumatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karakasli
authors.affiliation: 3 Department of Orthopaedics and Traumatology, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karaarslan
authors.affiliation: 4 Department of Anatomy, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Nermin Ng
authors.initials: NN
authors.lastname: Mas
authors.affiliation: 2 Department of Orthopaedics and Traumatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Hapa
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002812:Chondroma / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden; D055815:Young Adult
keywords: Cavalier’s principle; benign tumors; enchondroma; volumetric measurements