title: Current treatment strategies and nanocarrier based approaches for the treatment and management of diabetic retinopathy.
abstract: Diabetic retinopathy (DR) is a leading cause of blindness in all working age groups which contribute to patient's quality of life. Considering the anatomy and physiology of barriers in the eye, the treatment and management of pathologic ocular neovascularization in the posterior segment of the eye in DR is a challenging task. The current and emerging treatment strategies are discussed in this review for better understanding and treatment of the DR. Challenges in conventional therapy and recent developments in nanocarrier based approaches (polymeric, lipid nanoparticles, liposomes and dendrimers) and their advantages in targeting ocular tissues were also discussed in this review.
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
authors.forename: Kousalya
authors.initials: K
authors.lastname: Selvaraj
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
authors.forename: Kuppusamy
authors.initials: K
authors.lastname: Gowthamarajan
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
authors.forename: Veera Venkata Satyanarayana Reddy
authors.initials: VV
authors.lastname: Karri
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
authors.forename: Uday K
authors.initials: UK
authors.lastname: Barauah
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
authors.forename: Vanka
authors.initials: V
authors.lastname: Ravisankar
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
authors.forename: Gifty M
authors.initials: GM
authors.lastname: Jojo
mesh_terms: D003930:Diabetic Retinopathy / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D004337:Drug Carriers; D006801:Humans; D053758:Nanoparticles
chemical_list: D004337:Drug Carriers
keywords: Diabetic retinopathy; diabetes mellitus; nanoparticles; neovascularization; ophthalmic drug delivery; treatments