title: On the use of volumetric-modulated arc therapy for single-fraction thoracic vertebral metastases stereotactic body radiosurgery.
abstract: To retrospectively evaluate quality, efficiency, and delivery accuracy of volumetric-modulated arc therapy (VMAT) plans for single-fraction treatment of thoracic vertebral metastases using image-guided stereotactic body radiosurgery (SBRS) after RTOG 0631 dosimetric compliance criteria. After obtaining credentialing for MD Anderson spine phantom irradiation validation, 10 previously treated patients with thoracic vertebral metastases with noncoplanar hybrid arcs using 1 to 2 3D-conformal partial arcs plus 7 to 9 intensity-modulated radiation therapy beams were retrospectively re-optimized with VMAT using 3 full coplanar arcs. Tumors were located between T2 and T12. Contrast-enhanced T1/T2-weighted magnetic resonance images were coregistered with planning computed tomography and planning target volumes (PTV) were between 14.4 and 230.1cc (median = 38.0cc). Prescription dose was 16Gy in 1 fraction with 6MV beams at Novalis-TX linear accelerator consisting of micro multileaf collimators. Each plan was assessed for target coverage using conformality index, the conformation number, the ratio of the volume receiving 50% of the prescription dose over PTV, R50%, homogeneity index (HI), and PTV_1600 coverage per RTOG 0631 requirements. Organs-at-risk doses were evaluated for maximum doses to spinal cord (D0.03cc, D0.35cc), partial spinal cord (D10%), esophagus (D0.03ccand D5cc), heart (D0.03ccand D15cc), and lung (V5, V10, and maximum dose to 1000cc of lung). Dose delivery efficiency and accuracy of each VMAT-SBRS plan were assessed using quality assurance (QA) plan on MapCHECK device. Total beam-on time was recorded during QA procedure, and a clinical gamma index (2%/2mm and 3%/3mm) was used to compare agreement between planned and measured doses. All 10 VMAT-SBRS plans met RTOG 0631 dosimetric requirements for PTV coverage. The plans demonstrated highly conformal and homogenous coverage of the vertebral PTV with mean HI, conformality index, conformation number, and R50%values of 0.13 ± 0.03 (range: 0.09 to 0.18), 1.03 ± 0.04 (range: 0.98 to 1.09), 0.81 ± 0.06 (range: 0.72 to 0.89), and 4.2 ± 0.94 (range: 2.7 to 5.4), respectively. All 10 patients met protocol guidelines with maximum dose to spinal cord (average: 8.83 ± 1.9Gy, range: 5.9 to 10.9Gy); dose to 0.35cc of spinal cord (average: 7.62 ± 1.7Gy, range: 5.4 to 9.6Gy); and dose to 10% of partial spinal cord (average 6.31 ± 1.5Gy, range: 3.5 to 8.5Gy) less than 14, 10, and 10Gy, respectively. For all 10 patients, the maximum dose to esophagus (average: 9.41 ± 4.3Gy, range: 1.5 to 14.9Gy) and dose to 5cc of esophagus (average: 7.43 ± 3.8Gy, range: 1.1 to 11.8Gy) were kept less than protocol requirements 16Gy and 11.9Gy, respectively. In a similar manner, all 10 patients met protocol compliance criteria with maximum dose to heart (average: 4.62 ± 3.5Gy, range: 1.3 to 10.2Gy) and dose to 15cc of heart (average: 2.23 ± 1.8Gy, range: 0.3 to 5.6Gy) less than 22 and 16Gy, respectively. The dose to the lung was retained much lower than protocol guidelines for all 10 patients. The total number of monitor units was, on average, 6919 ± 1187. The average beam-on time was 11.5 ± 2.0 minutes. The VMAT plans demonstrated dose delivery accuracy of 95.8 ± 0.7%, on average, for clinical gamma passing rate with 2%/2mm criteria and 98.3 ± 0.8%, on average, with 3%/3mm criteria. All VMAT-SBRS plans were considered clinically acceptable per RTOG 0631 dosimetric compliance criteria. VMAT planning provided highly conformal and homogenous dose distributions for the lower-dose vertebral PTV and the spinal cord as well as organs-at-risk such as esophagus, heart, and lung. Higher QA pass rates and shorter beam-on time suggest that VMAT-SBRS is a clinically feasible, fast, and effective treatment option for patients with thoracic vertebral metastases.
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS. Electronic address: damodar.pokhrel@uky.edu.
authors.forename: Damodar
authors.initials: D
authors.lastname: Pokhrel
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Sumit
authors.initials: S
authors.lastname: Sood
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Christopher
authors.initials: C
authors.lastname: McClinton
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Xinglei
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Badkul
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Matthew
authors.initials: M
authors.lastname: Mallory
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Mellissa
authors.initials: M
authors.lastname: Mitchell
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, The University of Kansas Cancer Center, Kansas City, KS.
authors.forename: Christopher
authors.initials: C
authors.lastname: Lominska
mesh_terms: D019983:Guideline Adherence; D006801:Humans; D011829:Radiation Dosage; D016634:Radiosurgery; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D013904:Thoracic Vertebrae
keywords: RTOG 0631; Spine SBRS; VMAT