title: Lipidome determinants of maximal lifespan in mammals.
abstract: Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.
authors.affiliation: CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China. kasia.bozek@oist.jp.|Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany. kasia.bozek@oist.jp.|Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, 904-0495, Japan. kasia.bozek@oist.jp.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bozek
authors.affiliation: Skoltech Center for Computational and Systems Biology, Skolkovo Institute for Science and Technology, Novaya st. 100, Skolkovo, 143025, Russia.|Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoy Karetny per. 19/1, Moscow, 127051, Russia.
authors.forename: Ekaterina E
authors.initials: EE
authors.lastname: Khrameeva
authors.affiliation: Max-Delbrück Center for Molecular Medicine, Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa.
authors.forename: Jane
authors.initials: J
authors.lastname: Reznick
authors.affiliation: Max-Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13092, Berlin, Germany.
authors.forename: Damir
authors.initials: D
authors.lastname: Omerbašić
authors.affiliation: Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa.
authors.forename: Nigel C
authors.initials: NC
authors.lastname: Bennett
authors.affiliation: Max-Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13092, Berlin, Germany.
authors.forename: Gary R
authors.identifier: http://orcid.org/0000-0002-2890-6352
authors.initials: GR
authors.lastname: Lewin
authors.affiliation: University of Rochester, 434 Hutchison Hall, Rochester, NY, 14627-0211, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Azpurua
authors.affiliation: University of Rochester, 434 Hutchison Hall, Rochester, NY, 14627-0211, USA.
authors.forename: Vera
authors.initials: V
authors.lastname: Gorbunova
authors.affiliation: University of Rochester, 434 Hutchison Hall, Rochester, NY, 14627-0211, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Seluanov
authors.affiliation: SILABE, Primatology Center, University Louis Pasteur, Strasbourg, 4 Rue Blaise Pascal, 67070, France.
authors.forename: Pierrick
authors.initials: P
authors.lastname: Regnard
authors.affiliation: SILABE, Primatology Center, University Louis Pasteur, Strasbourg, 4 Rue Blaise Pascal, 67070, France.
authors.forename: Fanelie
authors.initials: F
authors.lastname: Wanert
authors.affiliation: UMR 7179/CNRS-MNHN, 1 avenue du Petit Chateu, 91800, Brunoy, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Marchal
authors.affiliation: UMR 7179/CNRS-MNHN, 1 avenue du Petit Chateu, 91800, Brunoy, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
authors.affiliation: UMR 7179/CNRS-MNHN, 1 avenue du Petit Chateu, 91800, Brunoy, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Dong Lu, Kunming, Yunnan, 650223, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Dong Lu, Kunming, Yunnan, 650223, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shi
authors.affiliation: Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany.
authors.forename: Svante
authors.initials: S
authors.lastname: Pääbo
authors.affiliation: Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Schroeder
authors.affiliation: Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Willmitzer
authors.affiliation: Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Germany. giavalisco@mpimp-golm.mpg.de.
authors.forename: Patrick
authors.initials: P
authors.lastname: Giavalisco
authors.affiliation: CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China. khaitovich@eva.mpg.de.|Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany. khaitovich@eva.mpg.de.|Skoltech Center for Computational and Systems Biology, Skolkovo Institute for Science and Technology, Novaya st. 100, Skolkovo, 143025, Russia. khaitovich@eva.mpg.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Khaitovich
mesh_terms: D000818:Animals; D002685:Chiroptera / Q000502:physiology*; D008055:Lipids / Q000032:analysis*; D008136:Longevity; D053858:Metabolic Networks and Pathways; D011323:Primates / Q000502:physiology*; D012377:Rodentia / Q000502:physiology*
chemical_list: D008055:Lipids