title: A Screen for Key Genes and Pathways Involved in High-Quality Brush Hair in the Yangtze River Delta White Goat.
abstract: The Yangtze River Delta White Goat is the only goat breed that produces high-quality brush hair, or type III hair, which is specialized for use in top-grade writing brushes. There has been little research, especially molecular research, on the traits that result in high-quality brush hair in the Yangtze River Delta White Goat. To explore the molecular mechanisms of the formation of high-quality brush hair, High-throughput RNA-Seq technology was used to compare skin samples from Yangtze River Delta White Goats that produce high-quality hair and non high-quality hair for identification of the important genes and related pathways that might influence the hair quality traits. The results showed that 295 genes were expressed differentially between the goats with higher and lower hair quality, respectively. Of those genes, 132 were up-regulated, 62 were down-regulated, and 101 were expressed exclusively in the goats with high-quality brush hair. Gene Ontology and Metabolic Pathway Significant Enrichment analyses of the differentially expressed genes indicated that the MAP3K1, DUSP1, DUSP6 and the MAPK signaling pathway might play important roles in the traits important for high-quality brush hair.
authors.affiliation: Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Guo
authors.affiliation: Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
authors.forename: Guohu
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
authors.forename: Kangle
authors.initials: K
authors.lastname: Qin
mesh_terms: D000818:Animals; D001947:Breeding; D054638:Dual Specificity Phosphatase 1 / Q000096:biosynthesis / Q000235:genetics; D054642:Dual Specificity Phosphatase 6 / Q000096:biosynthesis / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006041:Goats / Q000235:genetics* / Q000254:growth & development; D006197:Hair / Q000254:growth & development / Q000378:metabolism*; D018859:Hair Follicle / Q000254:growth & development / Q000378:metabolism*; D059014:High-Throughput Nucleotide Sequencing; D048369:MAP Kinase Kinase 1 / Q000096:biosynthesis; D048728:MAP Kinase Kinase Kinase 1 / Q000096:biosynthesis / Q000235:genetics; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D017423:Sequence Analysis, RNA; D012867:Skin / Q000254:growth & development / Q000378:metabolism
chemical_list: D012313:RNA; D048728:MAP Kinase Kinase Kinase 1; D048369:MAP Kinase Kinase 1; D054638:Dual Specificity Phosphatase 1; D054642:Dual Specificity Phosphatase 6