title: [Evidence for positive effects of long-term bisphosphonate administration.]
abstract: Long-term treatment studies on the use of bisphosphonate(BP)for more than 5 years have been reported for alendronate, risedronate, and zoledronic acid. Bone mineral density(BMD)increases over the long term;however, a large increase has been observed over a 2 to 3 year period after initiation of BP treatment followed by gradual BMD increase and achieving a state of stability. After an initial reduction, the levels of bone remodeling markers remained stable within the premenopausal range during long-term BP treatment. BPs reduce fracture risk over a 5 to 6 year period and residual anti-fracture effects are observed after discontinuation.
authors.affiliation: School of Health Science and Rehabilitation Division, Tottori University, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hagino
mesh_terms: D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D013995:Time
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates