title: [Expression of cytokeratin 19 in the development and progression of oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of cytokeratin 19 (CK19) in various stages of oral squamous cell carcinoma (OSCC), and to explore the relation between CK19 and OSCC.
  
  
  METHODS
  Forty-nine specimens including normal oral mucosa, epithelial hyperplasia, epithelial dysplasia, and oral squamous carcinoma were investigated. The expression of CK19 was detected by immunohistochemistry and Western blot. The serum of OSCC patients and healthy people was collected and CYFRA21-1 level was determined by ELISA. SPSS17.0 software package was used for data elevated.
  
  
  RESULTS
  CK19 was detectable in suprabasal cell layers in epithelia dysplasia and in oral cancer, especially in poorly-differentiated cancerous cells. With epithelia dysplasia becoming worse, the positive rate and the intensity of CKI9 raised significantly. CYKA21-1 in OSCC was significantly higher than that in normal control group(P<0.01).
  
  
  CONCLUSIONS
  CK19 overexpression is an early event in the process of oral mucosal canceration. Its abnormal expression can be used as one of the reliable indexes of early diagnosis of OSCC.
authors.affiliation: Department of Oral Medicine, Hospital of Stomatology, Luzhou Medical College. Luzhou 646000, Sichuan Province, China. E-mail:594829202@qq.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Tan
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Li
authors.forename: Min-Hai
authors.initials: MH
authors.lastname: Nie
mesh_terms: D000951:Antigens, Neoplasm; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D053539:Keratin-19 / Q000235:genetics / Q000378:metabolism*; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D053539:Keratin-19; C102012:antigen CYFRA21.1