title: Treatment of preeclampsia with hydroxychloroquine: a review.
abstract: In this review, we discuss the potential use of antimalarial drugs as an adjuvant therapy for preeclampsia, focusing on the mechanisms of action of this class of drugs in the context of preeclampsia. In particular, hydroxychloroquine has been shown to have various beneficial effects on patients with systemic lupus erythematosus. There are several pathways targeted by the antimalarial drugs that are similar to the pathophysiology of preeclampsia and hence offering opportunities to develop novel therapies to treat the disease. Given the safety profile of hydroxychloroquine in pregnancy, there is merit in exploring the efficacy of this drug as an adjuvant therapy in women with early onset preeclampsia.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , National University of Malaysia , Kuala Lumpur , Malaysia.|c The Ritchie Centre , Hudson Institute of Medical Research , Clayton , Victoria , Australia.
authors.forename: Rahana
authors.initials: R
authors.lastname: Abd Rahman
authors.affiliation: b Department of Medicine , School of Clinical Sciences, Monash University, Monash Medical Centre , Clayton , Victoria , Australia.
authors.forename: Philip
authors.initials: P
authors.lastname: DeKoninck
authors.affiliation: b Department of Medicine , School of Clinical Sciences, Monash University, Monash Medical Centre , Clayton , Victoria , Australia.
authors.forename: Padma
authors.identifier: http://orcid.org/0000-0003-2535-5134
authors.initials: P
authors.lastname: Murthi
authors.affiliation: b Department of Medicine , School of Clinical Sciences, Monash University, Monash Medical Centre , Clayton , Victoria , Australia.|c The Ritchie Centre , Hudson Institute of Medical Research , Clayton , Victoria , Australia.
authors.forename: Euan M
authors.identifier: http://orcid.org/0000-0002-4506-5233
authors.initials: EM
authors.lastname: Wallace
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology / Q000627:therapeutic use; D000962:Antimalarials / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000494:pharmacology / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy
chemical_list: D000277:Adjuvants, Pharmaceutic; D000962:Antimalarials; D006886:Hydroxychloroquine
keywords: Preeclampsia; antimalarial drugs; mechanisms of action