title: Added value of hepcidin quantification for the diagnosis and follow-up of anemia-related diseases.
abstract: Iron homeostasis is based on a strict control of both intestinal iron absorption and iron recycling through reticulo-endothelial system. Hepcidin controls the iron fluxes in order to maintain sufficient iron levels for erythropoietic activities, hemoproteins synthesis or enzymes function, but also to limit its toxic accumulation throughout the body. Hepcidin expression is regulated by various stimuli: inflammation and iron stimulate the production of the peptide, while anemia, erythropoiesis and hypoxia repress its production. Regulation of hepcidin expression is not so simple in complex pathological situations such as hemolytic anemia, cancer or chronic inflammation. Serum hepcidin quantification in association with the diagnostic tests currently available is quite promising for the diagnosis or the follow-up of anemia in those conditions. This study is part of the working group « Clinical interests of hepcidin quantification » of the Société française de biologie clinique.
authors.affiliation: Centre français des porphyries, Hôpitaux Universitaires Paris Nord Val de Seine site Louis Mourier, APHP, Colombes ; Inserm U1149, Centre de recherche sur l'inflammation, Paris, France.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Lefebvre
authors.affiliation: Lunam, Université d'Angers, Département anesthésie réanimation, CHU Angers, France.
authors.forename: Sigismond
authors.initials: S
authors.lastname: Lasocki
authors.affiliation: Laboratoire de biochimie, CHU Bicêtre AP-HP, Le Kremlin Bicêtre, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Fénéant-Thibault
authors.affiliation: Clinique Beau Soleil, Montpellier ; Labosud-Ocbiologie, Montpellier, France.
authors.forename: Pierre-Jean
authors.initials: PJ
authors.lastname: Lamy
authors.affiliation: Département d'hématologie biologique, Hôpital Saint Eloi, CHRU de Montpellier, Montpellier, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Cunat
authors.affiliation: Laboratoire de biochimie spécialisée - Hôpital Pontchaillou, CHU de Rennes, Rennes, France.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Ropert-Bouchet
authors.affiliation: Département d'hématologie biologique, Hôpital Saint Eloi, CHRU de Montpellier, Montpellier, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Aguilar-Martinez
authors.affiliation: Institut de médecine régénératrice et de biothérapies (IRMB)-Laboratoire de biochimie-protéomique clinique-CCBHM, Hôpital Saint Eloi, CHRU de Montpellier, Montpellier, France, Université de Montpellier, France, Inserm U1040, Montpellier, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lehmann
authors.affiliation: Institut de médecine régénératrice et de biothérapies (IRMB)-Laboratoire de biochimie-protéomique clinique-CCBHM, Hôpital Saint Eloi, CHRU de Montpellier, Montpellier, France, Université de Montpellier, France, Inserm U1040, Montpellier, France.
authors.forename: Constance
authors.initials: C
authors.lastname: Delaby
mesh_terms: D000740:Anemia / Q000150:complications* / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D064451:Hepcidins / Q000032:analysis* / Q000097:blood* / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D007501:Iron / Q000097:blood / Q000378:metabolism; D008991:Monitoring, Physiologic / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D015415:Biomarkers; D064451:Hepcidins; D007501:Iron
keywords: anemia; hepcidin; inflammation; iron