title: Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation.
abstract: Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.
authors.affiliation: Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Minsang
authors.identifier: http://orcid.org/0000-0001-8679-446X
authors.initials: M
authors.lastname: Shin
authors.affiliation: Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Hye Suk
authors.identifier: http://orcid.org/0000-0001-7568-3211
authors.initials: HS
authors.lastname: Kang
authors.affiliation: Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Bae
authors.affiliation: Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Dae Kyu
authors.initials: DK
authors.lastname: Song
authors.affiliation: Department of Physiology, Keimyung University School of Medicine, Daegu, Korea. ssim73@kmu.ac.kr.
authors.forename: Seung Soon
authors.identifier: http://orcid.org/0000-0002-2743-2108
authors.initials: SS
authors.lastname: Im
keywords: Insulin-like growth factor binding protein 2; Liver; Metabolic diseases; Transcriptional regulation