title: Brugada syndrome: Diagnosis, risk stratification and management.
abstract: Brugada syndrome is a rare inherited arrhythmia syndrome leading to an increased risk of sudden cardiac death, despite a structurally normal heart. Diagnosis is based on a specific electrocardiogram pattern, observed either spontaneously or during a sodium channel blocker test. Among affected patients, risk stratification remains a challenge, despite recent insights from large population cohorts. As implantable cardiac defibrillators - the main therapy in Brugada syndrome - are associated with a high rate of complications in this population, the main challenge is risk stratification of patients with Brugada syndrome. Aside from the two main predictors of arrhythmia (symptoms and spontaneous electrocardiogram pattern), many risk factors have been recently suggested for stratifying risk of sudden cardiac death in Brugada syndrome. We have reviewed these data and discuss current guidelines in light of recent progress in this complex field.
authors.affiliation: l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France. Electronic address: jeanbaptiste.gourraud@chu-nantes.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Gourraud
authors.affiliation: l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Barc
authors.affiliation: l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Thollet
authors.affiliation: l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Le Marec
authors.affiliation: l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Probst
mesh_terms: D053840:Brugada Syndrome / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control*; D017147:Defibrillators, Implantable / Q000592:standards; D004554:Electric Countershock / Q000009:adverse effects / Q000295:instrumentation* / Q000592:standards; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D006801:Humans; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Brugada syndrome; Diagnosis; Diagnostic; Mort subite; Prognosis; Pronostic; Risk stratification; Stratification du risque; Sudden cardiac death; Syndrome de Brugada