title: Relation between proprotein convertase subtilisin/kexin type 9 and directly measured low-density lipoprotein cholesterol.
abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of low-density lipoprotein cholesterol (LDL-C) receptor (LDL-R) recycling and, thus, is a determinant of plasma LDL-C concentration. We sought to determine the relation between serum concentrations of PCSK9 and LDL-C while considering a variety of influential variables, including treatment for dyslipidemia. Using a prospective lipid clinic registry, we evaluated clinical variables, the results of advanced lipid testing, and PCSK9 concentrations determined by immunoassay. We evaluated the relationship between directly measured LDL-C and PCSK9 in serum by performing a simple linear regression. Correlation analyses were performed to examine the relationships of PCSK9 to other clinical and laboratory values and to test for differences in median PCSK9 across patient groups. Factors identified as potential predictors were considered jointly in a multivariate model. For the 26 patients in the analyses, a relationship was not detected between LDL-C and PCSK9 (r= 0.009,P= 0.97); however, PCSK9 was correlated with C-peptide (r= 0.48;P= 0.01) and heart rate (r= 0.52;P= 0.006). Median PCSK9 values differed between statin users (284.0 ng/mL [quartile 1 = 241.0, quartile 3 = 468.0]) and nonusers (219.0 ng/mL [quartile 1 = 151.0, quartile 3 = 228.0];P= 0.02). More investigation is needed to evaluate the relationship between LDL and PCSK9, as well as the determinants of PCSK9, a major factor regulating cholesterol concentrations.
authors.affiliation: Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode); Texas A&M University Health Science Center College of Medicine, Dallas, Texas (Tecson, McCullough); Baylor University Medical Center at Dallas (McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (McCullough); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Tecson
authors.affiliation: Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode); Texas A&M University Health Science Center College of Medicine, Dallas, Texas (Tecson, McCullough); Baylor University Medical Center at Dallas (McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (McCullough); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Panettiere-Kennedy
authors.affiliation: Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode); Texas A&M University Health Science Center College of Medicine, Dallas, Texas (Tecson, McCullough); Baylor University Medical Center at Dallas (McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (McCullough); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
authors.forename: Jane I
authors.initials: JI
authors.lastname: Won
authors.affiliation: Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode); Texas A&M University Health Science Center College of Medicine, Dallas, Texas (Tecson, McCullough); Baylor University Medical Center at Dallas (McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (McCullough); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
authors.forename: Puja
authors.initials: P
authors.lastname: Garg
authors.affiliation: Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode); Texas A&M University Health Science Center College of Medicine, Dallas, Texas (Tecson, McCullough); Baylor University Medical Center at Dallas (McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (McCullough); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
authors.forename: Oluseun
authors.initials: O
authors.lastname: Olugbode
authors.affiliation: Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson, Panettiere-Kennedy, Won, Garg, Olugbode); Texas A&M University Health Science Center College of Medicine, Dallas, Texas (Tecson, McCullough); Baylor University Medical Center at Dallas (McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (McCullough); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
authors.forename: Peter A
authors.initials: PA
authors.lastname: McCullough