title: Targeted tumor detection: guidelines for developing biotinylated diagnostics.
abstract: The challenge in achieving precision medicine relies on how to advance and/or enhance new as well as old therapeutic strategies. Here, we highlight the significant role hydrophilicity of biotinylated fluorescent probe's plays on their cellular uptake behaviour.
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Jang
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Woo Ri
authors.initials: WR
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Amit
authors.initials: A
authors.lastname: Sharma
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Suk Hee
authors.initials: SH
authors.lastname: Cho
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. T.D.James@bath.ac.uk.
authors.forename: Tony D
authors.identifier: http://orcid.org/0000-0002-4095-2191
authors.initials: TD
authors.lastname: James
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Jong Seung
authors.identifier: http://orcid.org/0000-0003-3477-1172
authors.initials: JS
authors.lastname: Kim
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D001710:Biotin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D019921:Biotinylation; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D018613:Microscopy, Confocal / Q000379:methods; D008856:Microscopy, Fluorescence / Q000379:methods; D053644:Naphthalimides / Q000737:chemistry / Q000493:pharmacokinetics; D009369:Neoplasms / Q000000981:diagnostic imaging*; D061848:Optical Imaging / Q000379:methods*; D015363:Quinolones / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D005456:Fluorescent Dyes; D053644:Naphthalimides; D015363:Quinolones; C086538:4-amino-1,8-naphthalimide; D001710:Biotin; D015057:1-Naphthylamine