title: Design, synthesis and spectroscopic characterization of metal (II) complexes derived from a tetradentate macrocyclic ligand: Study on antimicrobial and antioxidant capacity of complexes.
abstract: The paper presents the synthesis of Co(II), Ni(II) and Cu(II) complexes of macrocyclic Schiff base ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and ethyl 3-oxobutanoate (2:2). The synthesized ligand and its metal complexes were characterized by elemental analyses, magnetic susceptibility measurements, FTIR, UV-Vis., mass1H NMR and X-ray diffraction. The Cu(II) complex exhibit distorted octahedral geometry, whereas an octahedral geometry is suggested for other complexes. The synthesized compounds were screened in vitro for their antimicrobial activities to evaluate their inhibiting potential against bacterial species Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus and fungal species include Aspergillus flavus, Aspergillus fumingatus, and Candida albicans. The complexation led to a remarkable increase in antimicrobial activity. In addition, the antioxidant activity of the compounds was also investigated through scavenging effect on DPPH radicals. The obtained IC50value of the DPPH activity for the copper complex was higher than other compounds.
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: parveezgull@gmail.com.
authors.forename: Parveez
authors.initials: P
authors.lastname: Gull
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Manzoor Ahmad
authors.initials: MA
authors.lastname: Malik
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Ovas Ahmad
authors.initials: OA
authors.lastname: Dar
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: dr.aahashmi@yahoo.co.in.
authors.forename: Athar Adil
authors.initials: AA
authors.lastname: Hashmi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000378:metabolism*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000378:metabolism; D005658:Fungi / Q000187:drug effects*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010851:Picrates / Q000378:metabolism*; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D056831:Coordination Complexes; D016166:Free Radical Scavengers; D047028:Macrocyclic Compounds; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Antimicrobial activity; Antioxidant activity; Macrocyclic ligand; Macrocyclic metal complexes; Spectroscopic studies; XRD