title: Successful treatment of tumour-induced osteomalacia after resection of an oral peripheral ossifying fibroma.
abstract: Tumour-induced osteomalacia is a paraneoplastic syndrome wherein bone is affected by a hormone from a tumour that causes renal phosphate wasting and hypophosphataemia. Here, we present the case of a 31-year-old man who has been suffering from generalised bone pains and a spine deformity that led to loss of height. Pertinent findings are low serum phosphorus, low vitamin D and decreased bone mineral density. These findings led to a diagnosis of osteomalacia. However, the finding of an oral mass raised some questions as to what role it plays in the patient's disease. It was suspected that the oral mass (fibroma) was producing a hormone that led to renal phosphate wasting, hypophosphataemia and then osteomalacia. This hypothesis was proven after surgical removal of the mass led to normalisation of the metabolic derangements and eventually led to a resolution of the bone pains.
authors.affiliation: Department of Physiology, College of Medicine, University of the Philippines Manila, Manila, Philippines.|Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors.forename: Mark Anthony Santiago
authors.initials: MA
authors.lastname: Sandoval
authors.affiliation: Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors.forename: Majorie Amoroto
authors.initials: MA
authors.lastname: Palermo
authors.affiliation: Department of Otorhinolaryngology, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors.forename: Ryner
authors.initials: R
authors.lastname: Carrillo
authors.affiliation: Spine Service, Department of Orthopedics, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors.forename: Rafael
authors.initials: R
authors.lastname: Bundoc
authors.affiliation: Departments of Pathology and Laboratories, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors.forename: Jose Ma
authors.initials: JM
authors.lastname: Carnate
authors.affiliation: Department of Radiology, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors.forename: Romelito Jose
authors.initials: RJ
authors.lastname: Galsim
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D018450:Disease Progression; D018214:Fibroma, Ossifying / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging; D007738:Kyphosis / Q000000981:diagnostic imaging / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008339:Mandibular Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D050279:Metacarpal Bones / Q000000981:diagnostic imaging; D008682:Metatarsal Bones / Q000000981:diagnostic imaging; D009372:Neoplasms, Connective Tissue / Q000000981:diagnostic imaging / Q000209:etiology*; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes; D011859:Radiography; D014457:Ulna / Q000000981:diagnostic imaging