title: Three new C-alkylated flavonoids from Desmodium oblongum.
abstract: Three new C-alkylated flavonoids, 4'-hydroxy-8-isobutyryl-7-methoxy-6-methyl-flavone (1), 4',7-dimethoxy-8-isobutyryl-6-methyl-flavone (2), and 4',7-dimethoxy-8-isobutyryl-flavone (3), together with three know ones luteolin (4), kaemferol (5), and quercetin (6), were isolated from Desmodium oblongum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 showed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC50values of 8.5, 6.5, and 7.8 μM; compound 2 showed cytotoxicity against SHSY5Y and PC3 cell lines with IC50values of 5.0 and 6.8 μM; compound 3 displayed cytotoxicity against SHSY5Y and MCF7 cell lines with IC50values of 6.4 and 9.4 μM, respectively.
authors.affiliation: a College of Pharmaceutic Science , Yunnan University of Traditional Chinese Medicine , Kunming 650500 , China.|b Engineering Laboratory for National Healthcare Theories and Products of Yunnan Province , Yunnan University of Nationalities , Kunming 650031 , China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Li
authors.affiliation: c Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan University of Nationalities , Kunming 650031 , China.
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
authors.affiliation: a College of Pharmaceutic Science , Yunnan University of Traditional Chinese Medicine , Kunming 650500 , China.|b Engineering Laboratory for National Healthcare Theories and Products of Yunnan Province , Yunnan University of Nationalities , Kunming 650031 , China.
authors.forename: Gao-Xiong
authors.initials: GX
authors.lastname: Rao
mesh_terms: D000477:Alkylating Agents; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C000623057:4',7-dimethoxy-8-isobutyryl-6-methyl-flavone; C000623059:4',7-dimethoxy-8-isobutyryl-flavone; C000623056:4'-hydroxy-8-isobutyryl-7-methoxy-6-methyl-flavone; D000477:Alkylating Agents; D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; C043562:flavone
keywords: Desmoditum oxyphyllum; Leguminosae; cytotoxicity; isoflavanone