title: Hearing regulatesDrosophilaaggression.
abstract: Aggression is a universal social behavior important for the acquisition of food, mates, territory, and social status. Aggression inDrosophilais context-dependent and can thus be expected to involve inputs from multiple sensory modalities. Here, we use mechanical disruption and genetic approaches inDrosophila melanogasterto identify hearing as an important sensory modality in the context of intermale aggressive behavior. We demonstrate that neuronal silencing and targeted knockdown of hearing genes in the fly's auditory organ elicit abnormal aggression. Further, we show that exposure to courtship or aggression song has opposite effects on aggression. Our data define the importance of hearing in the control ofDrosophilaintermale aggression and open perspectives to decipher how hearing and other sensory modalities are integrated at the neural circuit level.
authors.affiliation: Laboratory of Behavioral and Developmental Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.|VIB Center for the Biology of Disease, 3000 Leuven, Belgium.
authors.forename: Marijke
authors.initials: M
authors.lastname: Versteven
authors.affiliation: Laboratory of Behavioral and Developmental Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.|VIB Center for the Biology of Disease, 3000 Leuven, Belgium.
authors.forename: Lies
authors.initials: L
authors.lastname: Vanden Broeck
authors.affiliation: Department of Cellular Neurobiology, University of Göttingen, 37077 Goettingen, Germany.
authors.forename: Bart
authors.initials: B
authors.lastname: Geurten
authors.affiliation: Laboratory of Behavioral and Developmental Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.|VIB Center for the Biology of Disease, 3000 Leuven, Belgium.
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Zwarts
authors.affiliation: Laboratory of Behavioral and Developmental Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.|VIB Center for the Biology of Disease, 3000 Leuven, Belgium.|Department of Cellular Neurobiology, University of Göttingen, 37077 Goettingen, Germany.
authors.forename: Lisse
authors.initials: L
authors.lastname: Decraecker
authors.affiliation: Laboratory of Behavioral and Developmental Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.|VIB Center for the Biology of Disease, 3000 Leuven, Belgium.
authors.forename: Melissa
authors.initials: M
authors.lastname: Beelen
authors.affiliation: Department of Cellular Neurobiology, University of Göttingen, 37077 Goettingen, Germany.
authors.forename: Martin C
authors.initials: MC
authors.lastname: Göpfert
authors.affiliation: Department of Cellular Neurobiology, University of Göttingen, 37077 Goettingen, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Heinrich
authors.affiliation: Laboratory of Behavioral and Developmental Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; patrick.callaerts@kuleuven.be.|VIB Center for the Biology of Disease, 3000 Leuven, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: Callaerts
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003380:Courtship; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000502:physiology*; D005260:Female; D055785:Gene Knockdown Techniques; D006309:Hearing / Q000235:genetics / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D014828:Vocalization, Animal / Q000502:physiology
chemical_list: D029721:Drosophila Proteins
keywords: Drosophila; aggression; behavior; hearing; sensory modalities