title: Review: Receptor Targeted Nuclear Imaging of Breast Cancer.
abstract: Receptor targeted nuclear imaging directed against molecular markers overexpressed on breast cancer (BC) cells offers a sensitive and specific method for BC imaging. Currently, a few targets such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), somatostatin receptor (SSTR), and the gastrin releasing peptide receptor (GRPR) are being investigated for this purpose. Expression of these targets is BC subtype dependent and information that can be gained from lesion visualization is dependent on the target; ER-targeting radiotracers, e.g., can be used to monitor response to anti-estrogen treatment. Here we give an overview of the studies currently under investigation for receptor targeted nuclear imaging of BC. Main findings of imaging studies are summarized and (potential) purposes of lesion visualization by targeting these molecular markers are discussed. Since BC is a very heterogeneous disease and molecular target expression can vary per subtype, but also during disease progression or under influence of treatment, radiotracers for selected imaging purposes should be chosen carefully.
authors.affiliation: Department of Radiology & Nuclear medicine, Erasmus MC, Wytemaweg 80, 3015CN Rotterdam, The Netherlands. s.dalm@erasmusmc.nl.
authors.forename: Simone U
authors.initials: SU
authors.lastname: Dalm
authors.affiliation: Department of Radiology & Nuclear medicine, Erasmus MC, Wytemaweg 80, 3015CN Rotterdam, The Netherlands. j.verzijlbergen@erasmusmc.nl.
authors.forename: John Fred
authors.initials: JF
authors.lastname: Verzijlbergen
authors.affiliation: Department of Radiology & Nuclear medicine, Erasmus MC, Wytemaweg 80, 3015CN Rotterdam, The Netherlands. m.hendriks-dejong@erasmusmc.nl.
authors.forename: Marion
authors.initials: M
authors.lastname: De Jong
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface
keywords: ER; GRPR; HER2; PET; PR; SPECT; SSTR; breast cancer; receptor targeted nuclear imaging