title: Tenofovir alafenamide fumarate for the treatment of HIV infection.
abstract: Tenofovir alafenamide fumarate is a recently developed prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor with potent inhibitory activity against HIV. The utility of a previously developed tenofovir prodrug, tenofovir disoproxil fumarate, had been hampered by renal and bone mineral adverse events. Tenofovir alafenamide fumarate overcomes the shortcomings of tenofovir disoproxil fumarate by delivering high intracellular concentrations of the parent drug, tenofovir, while substantially reducing systemic exposure. Tenofovir alafenamide fumarate is currently available as a component of three fixed-dose products: i) coformulation with emtricitabine; ii) coformulation with elvitegravir, cobicistat and emtricitabine; and iii) coformulation with rilpivirine and emtricitabine.
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: R
authors.initials: R
authors.lastname: Sampath
authors.affiliation: Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: J
authors.initials: J
authors.lastname: Zeuli
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rizza
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA. temesgen.zelalem@mayo.edu.
authors.forename: Z
authors.initials: Z
authors.lastname: Temesgen
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000409:Alanine; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D000068698:Tenofovir / Q000031:analogs & derivatives
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir; C442442:tenofovir alafenamide; D000225:Adenine; D000409:Alanine
keywords: AIDS; Antiretroviral therapy; HIV; Nucleotide reverse tran-scriptase inhibitors; Tenofovir; Tenofovir alafenamide