title: Rabies Virus-Inspired Silica-Coated Gold Nanorods as a Photothermal Therapeutic Platform for Treating Brain Tumors.
abstract: Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These nanorods not only resemble the appearance of the actual rabies virus but also travel into the brain through the neuronal pathway bypassing the blood-brain barrier, and moreover respond to near-infrared laser (808 nm) irradiation, emit heat, and effectively suppress brain tumors.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
authors.forename: Changkyu
authors.initials: C
authors.lastname: Lee
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
authors.forename: Ha Shin
authors.initials: HS
authors.lastname: Hwang
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
authors.forename: Sungin
authors.initials: S
authors.lastname: Lee
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
authors.forename: Bomi
authors.initials: B
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan, 38541, Republic of Korea.
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea.
authors.forename: Kyung Taek
authors.initials: KT
authors.lastname: Oh
authors.affiliation: Division of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Hanyang University, Ansan, 15588, Republic of Korea.
authors.forename: Han-Gon
authors.initials: HG
authors.lastname: Choi
authors.affiliation: School of Pharmacy, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
authors.forename: Yu Seok
authors.initials: YS
authors.lastname: Youn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D002470:Cell Survival; D005910:Glioma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D053685:Laser Therapy; D008297:Male; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes; D009368:Neoplasm Transplantation; D011820:Rabies virus; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000378:metabolism; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents
keywords: brain tumors; gold nanorods; localized surface plasmon resonance; photothermal therapy; rabies virus