title: Respiratory Difficulties in Children With Underlying Asthma During Immunotherapy for High-risk Neuroblastoma.
abstract: Treatment of high-risk neuroblastoma now includes antibody based antitumor immunotherapy as part of standard care. Although this therapy has resulted in dramatic improvements in survival, it is associated with significant side effects. Children with underlying respiratory issues, and in particular asthma, may be more susceptible to immunotherapy associated respiratory compromise and pulmonary complications. Early routine involvement of pulmonology care is warranted for these patients in an effort to allow maximal delivery of immunotherapy and minimize acute and long-term complications.
authors.affiliation: *Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta †Division of Pediatric Pulmonology ∥Division of Radiation Oncology, Emory University, Atlanta, GA ‡Division of Pediatric Allergy, Immunology, and Pulmonology Medicine §Division of Pediatric Hematology/Oncology, Vanderbilt University School of Medicine, and Monroe Carell Jr Children's Hospital, Nashville, TN.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Metrock
authors.forename: Muna
authors.initials: M
authors.lastname: Qayed
authors.forename: Dawn
authors.initials: D
authors.lastname: Simon
authors.forename: Thomas
authors.initials: T
authors.lastname: Cash
authors.forename: Michael G
authors.initials: MG
authors.lastname: O'Connor
authors.forename: Shaina
authors.initials: S
authors.lastname: Johnson
authors.forename: Natia
authors.initials: N
authors.lastname: Esiashvili
authors.forename: Howard M
authors.initials: HM
authors.lastname: Katzenstein
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001249:Asthma / Q000150:complications*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008297:Male; D009447:Neuroblastoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000175:diagnosis* / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal