title: Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor.
abstract: Skin cancer incidence has been increasing in the last decades, but most of the commercial formulations used as sunscreens are designed to protect only against solar erythema. Many of the active components present in sunscreens show critical weaknesses, such as low stability and toxicity. Thus, the development of more efficient components is an urgent health necessity and an attractive industrial target. We have rationally designed core moieties with increased photoprotective capacities and a new energy dissipation mechanism. Using these scaffolds, we have synthesized a series of compounds with tunable properties suitable for their use in sunscreens, and enhanced properties in terms of stability, light energy dissipation, and toxicity. Moreover, some representative compounds were included in final sunscreen formulations and a relevant solar protection factor boost was measured.
authors.affiliation: Department of Chemistry, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006, Logroño, Spain.
authors.forename: Raúl
authors.identifier: 0000-0001-5207-654X
authors.initials: R
authors.lastname: Losantos
authors.affiliation: Department of Chemistry, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006, Logroño, Spain.
authors.forename: Ignacio
authors.identifier: 0000-0002-5843-9660
authors.initials: I
authors.lastname: Funes-Ardoiz
authors.affiliation: Department of Dermatology, Centro de Investigaciones Médico Sanitarias, Facultad de Medicina, Universidad de Málaga, Boulevard Louis Pasteur s/n, 29071, Málaga, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Aguilera
authors.affiliation: Department of Dermatology, Centro de Investigaciones Médico Sanitarias, Facultad de Medicina, Universidad de Málaga, Boulevard Louis Pasteur s/n, 29071, Málaga, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Herrera-Ceballos
authors.affiliation: Department of Chemistry, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006, Logroño, Spain.|Department of Physical Chemistry, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Iriepa
authors.affiliation: Department of Chemistry, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006, Logroño, Spain.
authors.forename: Pedro J
authors.identifier: 0000-0002-8917-0318
authors.initials: PJ
authors.lastname: Campos
authors.affiliation: Department of Chemistry, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006, Logroño, Spain.
authors.forename: Diego
authors.identifier: 0000-0003-2772-6453
authors.initials: D
authors.lastname: Sampedro
keywords: ab initio calculations; chromophores; photoprotection; sunscreens