title: Subclinical atherosclerosis detected by coronary computed tomographic angiography in Qatar: a comparison between Qataris and south Asian migrants.
abstract: OBJECTIVE
  There are limited data regarding subclinical atherosclerosis in Middle Eastern countries. We aimed to describe and compare coronary computed tomographic angiography (CCTA) findings in Qatari native and South Asian migrants at increased risk of coronary artery disease (CAD).
  
  
  METHODS
  We performed CCTA in 251 consecutive volunteers (126 South Asian, 125 Qatari, mean age 50.0 ± 7.3 years, 27.1% female) at increased risk of cardiovascular disease. Given differences in baseline risk factors, we employed propensity score matching to create a cohort of 162 subjects for comparative analyses. We compared CAD severity, extent, plaque morphology, adverse plaque characteristics, and quantitative measures of atherosclerotic burden in both subgroups.
  
  
  RESULTS
  After matching, no CAD was seen in 58.0% of South Asians and 49.4% of Qataris (p = 0.3), while obstructive CAD (≥50% luminal stenosis) was present in 40.7% of South Asians and 49.4% of Qataris (p = 0.3). There was a high prevalence of adverse plaque characteristics in both ethnicities, particularly positive remodeling. South Asians had significantly smaller vessel and lumen volumes, but the percent aggregate plaque volumes were not significantly different (2.9 ± 6.3% vs. 3.8 ± 8.0%, p = 0.4).
  
  
  CONCLUSIONS
  In this first study of CCTA findings performed in a Middle Eastern country, we observed a high prevalence of obstructive CAD in a middle-aged cohort. There were no significant differences in CCTA findings between Qataris and South Asians after adjustment for clinical risk factors. Future studies are needed to identify patterns of coronary atherosclerosis by CCTA in non-European populations where cardiovascular disease is increasingly prevalent.
authors.affiliation: Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College and New York Presbyterian Hospital, 413 East 69th Street, Suite 108, New York, NY, 10021, USA.|Division of Cardiology, Albany Medical Center, Albany, NY, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Schulman-Marcus
authors.affiliation: Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Ran
authors.initials: R
authors.lastname: Heo
authors.affiliation: Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Heidi
authors.initials: H
authors.lastname: Gransar
authors.affiliation: Hamad Medical Corporation, Doha, Qatar.
authors.forename: Jassim Al
authors.initials: JA
authors.lastname: Suwaidi
authors.affiliation: Hamad Medical Corporation, Doha, Qatar.
authors.forename: Maryam
authors.initials: M
authors.lastname: Alkuwari
authors.affiliation: Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College and New York Presbyterian Hospital, 413 East 69th Street, Suite 108, New York, NY, 10021, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Elmore
authors.affiliation: Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College and New York Presbyterian Hospital, 413 East 69th Street, Suite 108, New York, NY, 10021, USA.
authors.forename: Mille J
authors.initials: MJ
authors.lastname: Gomez
authors.affiliation: Hamad Medical Corporation, Doha, Qatar.
authors.forename: Amin
authors.initials: A
authors.lastname: Jayyousi
authors.affiliation: Hamad Medical Corporation, Doha, Qatar.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Zirie
authors.affiliation: Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College and New York Presbyterian Hospital, 413 East 69th Street, Suite 108, New York, NY, 10021, USA.
authors.forename: James K
authors.initials: JK
authors.lastname: Min
authors.affiliation: Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College and New York Presbyterian Hospital, 413 East 69th Street, Suite 108, New York, NY, 10021, USA. jmp2003@med.cornell.edu.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Peña
mesh_terms: D000328:Adult; D000368:Aged; D018912:Arabs; D001208:Asia; D044466:Asian People; D058070:Asymptomatic Diseases; D016009:Chi-Square Distribution; D000072226:Computed Tomography Angiography; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000208:ethnology*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000208:ethnology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D015995:Prevalence; D057216:Propensity Score; D011446:Prospective Studies; D011780:Qatar / Q000453:epidemiology; D012307:Risk Factors; D014171:Transients and Migrants
keywords: Atherosclerosis; Coronary computed tomographic angiography; Ethnicity