title: Challenges with Mosquito-borne Viral Diseases: Outbreak of the Monsters.
abstract: BACKGROUND
  The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day. Zika virus may damage brain by targeting the neuron cells in babies, and thereby it is very perilous to pregnant women. Dangerous Type: A less common but highly dangerous type of dengue is one which causes haemorrhagic fever and shock syndrome which are lethal. Chikungunya is not as lethal as Zika and dengue are, but it triggers joints pain which could last for months and even for years.
  
  
  CONCLUSIONS
  The vaccines against Zika, dengue and chikungunya viruses are at different stages of development. The challenges associated with the epidemic wave of Zika, dengue and chikungunya viruses have been explained and the current status of drug/ vaccine development against these viruses has been reviewed.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi-110007. India.
authors.forename: Renu
authors.initials: R
authors.lastname: Gautam
authors.affiliation: Department of Chemistry, HMR Institute of Technology and Management, GGSIP University, New Delhi. India.
authors.forename: Sweta
authors.initials: S
authors.lastname: Mishra
authors.affiliation: Department of Chemistry, Deshbandhu College, University of Delhi, Delhi-110019. India.
authors.forename: Archana
authors.initials: A
authors.lastname: Milhotra
authors.affiliation: Department of Chemistry, University of Delhi, Delhi-110007. India.
authors.forename: Ritika
authors.initials: R
authors.lastname: Nagpal
authors.affiliation: Special Center for Molecular medicine, JNU, New Delhi, Delhi-110067. India.
authors.forename: Mradul
authors.initials: M
authors.lastname: Mohan
authors.affiliation: Department of Chemistry, University of Delhi, Delhi-110007. India.
authors.forename: Anchal
authors.initials: A
authors.lastname: Singhal
authors.affiliation: Department of Chemistry, Deshbandhu College, University of Delhi, Delhi-110019. India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Kumari
mesh_terms: D000818:Animals; D065632:Chikungunya Fever / Q000453:epidemiology / Q000635:transmission*; D003715:Dengue / Q000453:epidemiology / Q000635:transmission*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D000072138:Mosquito Vectors / Q000821:virology*; D011247:Pregnancy; D000071243:Zika Virus Infection / Q000453:epidemiology / Q000635:transmission*
keywords: Chikungunya; Dengue; Mosquito-borne diseases; Vaccine; Viral diseases; Zika