title: Decreased functional connectivity between the dorsal anterior cingulate cortex and lingual gyrus in Alzheimer's disease patients with depression.
abstract: Depression is one of the most common psychiatric symptoms in Alzheimer's disease (AD), occurring in up to 40% of AD patients. It influences the cognitive function of patients and increases the burden on their caregivers. Currently, there are few effective medical treatments for reducing the symptoms of depression in AD patients. Understanding the underlying neurobiological mechanisms in AD patients with depression (D-AD) is crucial for developing effective interventions. The anterior cingulate cortex (ACC) is an important brain region involved in emotional and cognitive processing. Several functional magnetic resonance imaging studies have shown that patients with major depressive disorder have structural, functional, and metabolic abnormalities in the ACC.
  
  
  
  We investigated the resting-state functional connectivity (FC) of ACC subregions in 15 D-AD patients and 17 non-depressed AD (nD-AD) patients, by parcellating the ACC into the rostral and dorsal ACC (dACC).
  
  
  
  Our results revealed that D-AD patients have decreased FC between the dACC and the right occipital lobe and right lingual gyrus, compared with nD-AD patients.
  
  
  
  Decreased FC between the dACC and the right occipital lobe and right lingual gyrus may play an important role in the neuropathophysiology of depression in AD.
authors.affiliation: China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
authors.forename: Xiaozheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Hou
authors.affiliation: Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.
authors.forename: Xingli
authors.initials: X
authors.lastname: Chen
authors.affiliation: Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Seventh Hospital of Hangzhou, Hangzhou, Zhejiang, 310013, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China. Electronic address: guozw1977@aliyun.com.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Guo
authors.affiliation: China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. Electronic address: bghu79@126.com.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Bai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D015897:Comorbidity; D063132:Connectome / Q000379:methods*; D003863:Depression / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*
keywords: Alzheimer's disease; Anterior cingulate cortex; Depression; Functional connectivity; Functional magnetic resonance imaging