title: Nuclear membrane stretch and its role in mechanotransduction.
abstract: Most research in nuclear mechanotransduction has focused on the nuclear lamina and lamin binding proteins. These structures provide mechanical stability to the nucleus, establish a link between the cytoskeleton and chromatin, and can transmit mechanical signals. At the same time, mechanical perturbations to the nucleus also affect its phospholipid membranes. In this commentary, we discuss how changes in nuclear membrane tension can mediate mechanotransduction.
authors.affiliation: b Heart and Vascular Center , Semmelweis University , Budapest , Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Enyedi
authors.affiliation: a Cell Biology Program , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Philipp
authors.initials: P
authors.lastname: Niethammer
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D055595:Mechanical Phenomena; D040542:Mechanotransduction, Cellular
keywords: cPL; cell lysis; cell swelling; inflammatory signals; mechanosensing; membrane tension; nuclear envelope