title: Lung cancer and miRNAs: a possible remedy for anti-metastatic, therapeutic and diagnostic applications.
abstract: Lung cancer still accounts for the leading cause of cancer-related deaths worldwide and despite the emerging advances in diagnostic and therapeutic techniques it remains to be a serious global public health concern. Micro-ribonucleic acids (microRNAs) are responsible for invasion and metastasis of various tumors including lung cancer which underscores the necessity of understanding their functions. Areas covered: Herein, we aim to summarize the recent advances made in our understanding of the miRNAs with special reference to lung cancer. Moreover, the role of miRNAs in crucial cellular processes will be elucidated. Various applications of the miRNAs would be explained and different kinds of them would be discussed to delineate their significance in lung cancer biology, therapy and diagnosis. Expert commentary: the miRNA study in the field of respiratory disease and specially lung cancer has emerged lately. Given the several miRNAs, which are in the clinical trials, this field is passing through its maturation phase which ultimately could rise to a robust tool for lung cancer therapy, diagnosis and prevention.
authors.affiliation: a Department of Medical Biotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical Science , Tehran , Iran.
authors.forename: Zahra Sadat
authors.initials: ZS
authors.lastname: Hashemi
authors.affiliation: b Department of Clinical Laboratory Sciences , Dezful University of Medical Sciences , Dezful , Iran.|c Department of Medical Biotechnology, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Khalili
authors.affiliation: c Department of Medical Biotechnology, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Forouzandeh Moghadam
authors.affiliation: a Department of Medical Biotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical Science , Tehran , Iran.
authors.forename: Esmaeil
authors.initials: E
authors.lastname: Sadroddiny
mesh_terms: D015415:Biomarkers; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Lung cancer; exosome; metastamiR; miR-therapy; microRNA