title: Effects of agmatine sulphate on facial nerve injuries.
abstract: OBJECTIVE
  To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.
  
  
  METHODS
  The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.
  
  
  RESULTS
  Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).
  
  
  CONCLUSIONS
  Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.
authors.affiliation: Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Surmelioglu
authors.affiliation: Department of Histology,Faculty of Medicine,Cukurova University,Adana,Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Sencar
authors.affiliation: Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ozdemir
authors.affiliation: Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Tarkan
authors.affiliation: Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Dagkiran
authors.affiliation: Department of Clinical Pharmacy,Faculty of Pharmacy,Cukurova University,Adana,Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Surmelioglu
authors.affiliation: Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Tuncer
authors.affiliation: Department of Histology,Faculty of Medicine,Cukurova University,Adana,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Polat
mesh_terms: D000376:Agmatine / Q000494:pharmacology*; D000714:Anastomosis, Surgical; D000818:Animals; D005154:Facial Nerve / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D020220:Facial Nerve Injuries / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects*; D010865:Pilot Projects; D051381:Rats; D017208:Rats, Wistar; D013431:Sulfates / Q000494:pharmacology
chemical_list: D013431:Sulfates; D000376:Agmatine
keywords: Agmatine; Facial Nerve; Nerve Regeneration