title: Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation.
abstract: Radiotherapy and immune checkpoint blockade are effective treatments for melanoma. Recent preclinical studies have suggested an interaction of radiotherapy and immune checkpoint blockade. Retrospective clinical studies, as well as a small number of prospective studies, have been undertaken to explore this interaction in patients with melanoma. In this review, we present the results of clinical studies combining radiotherapy and immune checkpoint blockade and conclude that this is a promising strategy worth of further investigation.
authors.affiliation: From the *Department of Radiation Oncology, †Melanoma and Immunotherapeutics Oncology Service, Department of Medicine, and ‡Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Freddy E
authors.initials: FE
authors.lastname: Escorcia
authors.forename: Michael A
authors.initials: MA
authors.lastname: Postow
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Barker
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008545:Melanoma / Q000188:drug therapy / Q000276:immunology / Q000532:radiotherapy / Q000628:therapy*; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000276:immunology; D026901:Membrane Transport Proteins / Q000276:immunology; D061026:Programmed Cell Death 1 Receptor / Q000037:antagonists & inhibitors* / Q000276:immunology; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; C484524:SLC44A2 protein, human