title: Cutaneous necrosis secondary to terlipressin therapy. A rare but serious side effect. Case report and literature review.
abstract: Terlipressin is a vasopressin analogue used in esophageal variceal bleeding and hepatorenal syndrome management. It is a safe drug with mild secondary effects. However, potentially serious ischemic complications may occur, such as cutaneous necrosis. It is useful to recognize these events early, in order to withdraw terlipressin and introduce other adjuvant drugs if needed. We report a detailed case of cutaneous necrosis secondary to terlipressin administration and present a case review of patients, describing their characteristics, risk factors, lesion locations, doses, methods of administration and possible treatments.
authors.affiliation: Medicina Interna, Hospital Universitario de Burgos, España.
authors.forename: Enrique
authors.initials: E
authors.lastname: Iglesias Julián
authors.affiliation: Aparato Digestivo, Hospital Universitario de Burgos.
authors.forename: Ester
authors.initials: E
authors.lastname: Badía Aranda
authors.affiliation: Aparato Digestivo, Hospital Universitario de Burgos.
authors.forename: Belén
authors.initials: B
authors.lastname: Bernad Cabredo
authors.affiliation: Anatomía Patológica, Hospital Universitario de Burgos.
authors.forename: Daniel
authors.initials: D
authors.lastname: Corrales Cruz
authors.affiliation: Aparato Digestivo, Hospital Universitario de Burgos.
authors.forename: María José
authors.initials: MJ
authors.lastname: Romero Arauzo
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008236:Lypressin / Q000009:adverse effects / Q000031:analogs & derivatives*; D009336:Necrosis / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
chemical_list: D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin