title: Occurrence ofblaKPC-2,blaCTX-M, andmcr-1in Enterobacteriaceae from Well Water in Rural China.
abstract: We report on the coexistence ofmcr-1andblaCTX-Min multidrug-resistant, extended-spectrum β-lactamase-producingEscherichia colibelonging to the sequence type 10 complex isolated from well water in rural China.Raoultella ornithinolyticawithblaKPC-2was also detected in well water from the same area. This study shows that genes coding for resistance to last-resort antibiotics are present in wells in rural China, indicating a potential source of antibiotic resistance.
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Sun
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
authors.forename: Zhenwang
authors.initials: Z
authors.lastname: Bi
authors.affiliation: Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Maud
authors.initials: M
authors.lastname: Nilsson
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Beiwen
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Berglund
authors.affiliation: Global Health-Health Systems and Policy, Department of Public Health Sciences, Karolinska Institutet, Solna, Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Stålsby Lundborg
authors.affiliation: Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, Uppsala, Sweden.
authors.forename: Stefan
authors.initials: S
authors.lastname: Börjesson
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China lxw@sdu.edu.cn.
authors.forename: Xuewen
authors.initials: X
authors.lastname: Li
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Lennart E
authors.initials: LE
authors.lastname: Nilsson
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002681:China; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases
keywords: ESBL; antibiotic resistance; mcr-1