title: [Pathological Complete Response in a Case of Advanced Esophageal Cancer with Widespread Lymph Node Metastases Treated Using Preoperative Chemotherapy with Docetaxel, Cisplatin, and 5-FU(DCF therapy)].
abstract: The patient was a 66-year-old woman, who was diagnosed with cT3N3M0, cStage III esophageal cancer with widespread lymph node metastases in the mediastinum and abdomen. She was treated with 2 courses of chemotherapy with docetaxel/ cisplatin/5-FU(DCF therapy). CT and FDG PET-CT showed a significant reduction in both the primary tumor and the metastatic lymph nodes following treatment. We performed subtotal esophagectomy and gastric tube reconstruction with lymphadenectomy. The histopathological findings showed no residual viable tumor cells or foreign body-type giant cells with necrosis. The pathological effect of chemotherapy was defined as Grade 3(pCR). Our case suggested that DCF chemotherapy is potentially a very effective treatment for advanced esophageal cancer with widespread lymph node metastases.
authors.affiliation: Dept. of Surgery, Japan Community Health care Organization(JCHO) Osaka Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Noro
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hirao
authors.forename: Shohei
authors.initials: S
authors.lastname: Takaichi
authors.forename: Chihyon
authors.initials: C
authors.lastname: Son
authors.forename: Kazuya
authors.initials: K
authors.lastname: Iwamoto
authors.forename: Emiko
authors.initials: E
authors.lastname: Kono
authors.forename: Keigo
authors.initials: K
authors.lastname: Yasumasa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mizuno
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hatanaka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamasaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D020360:Neoadjuvant Therapy; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil