title: Management of sleep disorders in Parkinson's disease and multiple system atrophy.
abstract: Parkinson's disease (PD) and multiple system atrophy (MSA) are disorders associated with α synuclein-related neurodegeneration. Nonmotor symptoms are common hallmarks of these disorders, and disturbances of the sleep-wake cycle are among the most common nonmotor symptoms. It is only recently that sleep disturbances have received the attention of the medical and research community. Significant progress has been made in understanding the pathophysiology of sleep and wake disruption in alphasynucleinopathies during the past few decades. Despite these advancements, treatment options are limited and frequently associated with problematic side effects. Further studies that center on the development of novel treatment approaches are very much needed. In this article, the author discusses the current state of the management of disturbed sleep and alertness in PD and MSA. © 2017 International Parkinson and Movement Disorder Society.
authors.affiliation: Movement Disorders Unit and Division of Sleep Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Videnovic
mesh_terms: D021081:Chronobiology Disorders / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D019468:Disease Management; D006970:Disorders of Excessive Somnolence / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D019578:Multiple System Atrophy / Q000150:complications / Q000628:therapy*; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D020187:REM Sleep Behavior Disorder / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D012148:Restless Legs Syndrome / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D012893:Sleep Wake Disorders / Q000150:complications / Q000503:physiopathology / Q000628:therapy*
keywords: Parkinson's; management; multiple system atrophy; sleep