title: [The safety of anti-diabetic drugs in heart failure].
abstract: The association of diabetes and heart failure is very common, furthermore, the pathophysiology and clinical course of the two entities have many crossing-points. Today, the spectrum of available anti-diabetic drugs is extremely wide, ranging from the classical (insulin, biguanides, sulphonylureas) to the most recent agents (gliptins, gliflozins). The cardiovascular effects of these drugs are multiple, their knowledge is important in the everyday practice, as the use of safe drugs regarding of heart failure is preferred. Our work provides an overview of each class of drugs after the presentation of the mechanism of action and the main representatives, the effects on the cardiovascular system, including those on heart failure will be described, mentioning the results of the most important clinical trials. The available data confirm the beneficial effects of metformin and gliflozins and the harmful effect of thiazolidinediones in heart failure. The other classes of drugs are permitted in heart failure, but it is important to continuously monitor the signs of decompensation. Orv. Hetil., 2017. 158(5), 163-171.
authors.affiliation: IV. Belgyógyászati Tanszék, Marosvásárhelyi Orvosi és Gyógyszerészeti Egyetem (Internal Medicine IV Gh., UMF Tg. Mureș) Marosvásárhely, Románia (Marinescu str. 1., 540400 Târgu Mureş, Romania).
authors.forename: Attila
authors.initials: A
authors.lastname: Frigy
authors.affiliation: III. Belgyógyászati Tanszék, Marosvásárhelyi Orvosi és Gyógyszerészeti Egyetem (UMF Tg. Mureș) Marosvásárhely, Románia.
authors.forename: Márta
authors.initials: M
authors.lastname: Germán-Salló
authors.affiliation: VII. Belgyógyászati Tanszék, Marosvásárhelyi Orvosi és Gyógyszerészeti Egyetem (UMF Tg. Mureș) Marosvásárhely, Románia.
authors.forename: Lehel
authors.initials: L
authors.lastname: Máthé
authors.affiliation: III. Belgyógyászati Tanszék, Marosvásárhelyi Orvosi és Gyógyszerészeti Egyetem (UMF Tg. Mureș) Marosvásárhely, Románia.
authors.forename: Mónika
authors.initials: M
authors.lastname: Szabó
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use*; D045162:Thiazolidinediones / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D008687:Metformin
keywords: anti-diabetic agents; diabetes mellitus; heart failure; szívelégtelenség; vércukorcsökkentő gyógyszerek