title: Biomarkers of oxidative stress in electroplating workers exposed to hexavalent chromium.
abstract: This study evaluates levels of biomarkers of oxidative DNA damage and lipid peroxidation in 105 male workers at 16 electroplating companies who had been exposed to hexavalent chromium (Cr(VI)). The study participants were 230 non-smoking male workers, comprising 105 electroplating workers who had been exposed to chromium and 125 control subjects who performed office tasks. Personal air samples, spot urine samples, hair samples, fingernail samples and questionnaires were used to quantify exposure to Cr(VI), oxidative DNA damage, lipid peroxidation, and environmental pollutants. Both the geometric mean personal concentrations of Cr(VI) of the Cr-exposed workers and the total Cr concentrations in the air to which they were exposed significantly exceeded those for the control subjects. The geometric mean concentrations of Cr in urine, hair and fingernails, and the urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA) levels in the Cr(VI) exposed workers exceeded those in the control subjects. Daily cumulative Cr(VI) exposure and urinary Cr were significantly correlated with urinary 8-OHdG levels following adjustments for covariates. A ten-fold increase in urinary Cr level was associated with a 1.73-fold increase in urinary 8-OHdG level. Daily cumulative Cr(VI) exposure and urinary Cr level were significantly correlated with urinary MDA level following adjustments for covariates. A ten-fold increase in urinary Cr was associated with a 1.45-fold increase in urinary MDA. Exposure to Cr(VI) increased oxidative DNA injury and the oxidative deterioration of lipids in electroplating workers.
authors.affiliation: Institute of Labor, Occupational Safety and Health, Ministry of Labor, New Taipei City, Taiwan.|School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chih-Hong
authors.initials: CH
authors.lastname: Pan
authors.affiliation: School of Community and Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, Virginia, USA.
authors.forename: Hueiwang Anna
authors.initials: HA
authors.lastname: Jeng
authors.affiliation: School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Ching-Huang
authors.initials: CH
authors.lastname: Lai
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000652:urine*; D015415:Biomarkers / Q000032:analysis* / Q000652:urine; D016022:Case-Control Studies; D002857:Chromium / Q000652:urine*; D004595:Electroplating; D004784:Environmental Monitoring; D006197:Hair / Q000737:chemistry; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009262:Nails / Q000737:chemistry; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis*; D018384:Oxidative Stress; D011795:Surveys and Questionnaires
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D002857:Chromium; C074702:chromium hexavalent ion