title: Bioinspired Universal Monolayer Coatings by Combining Concepts from Blood Protein Adsorption and Mussel Adhesion.
abstract: Despite the increasing need for universal polymer coating strategies, only a few approaches have been successfully developed, and most of them are suffering from color, high thickness, or high roughness. In this paper, we present for the first time a universal monolayer coating that is only a few nanometers thick and independent of the composition, size, shape, and structure of the substrate. The coating is based on a bioinspired synthetic amphiphilic block copolymer that combines two concepts from blood protein adsorption and mussel adhesion. This polymer can be rapidly tethered on various substrates including both planar surfaces and nanosystems with high grafting density. The resulting monolayer coatings are, on the one hand, inert to the adsorption of multiple polymer layers and prevent biofouling. On the other hand, they are chemically active for secondary functionalization and provide a new platform for selective material surface modification.
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Leixiao
authors.initials: L
authors.lastname: Yu
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Chong
authors.identifier: http://orcid.org/0000-0002-6872-2240
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.|Multifunctional Biomaterials for Medicine, Helmholtz Virtual Institute , Kantstrasse 55, 14513 Teltow-Seehof, Germany.|Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH , Hahn-Meitner-Platz 1, 14109 Berlin, Germany.
authors.forename: Qidi
authors.initials: Q
authors.lastname: Ran
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schlaich
authors.affiliation: Fraunhofer Institute for Manufacturing Technology and Advanced Materials , Wiener Strasse 12, 28359 Bremen, Germany.
authors.forename: Paul-Ludwig Michael
authors.initials: PM
authors.lastname: Noeske
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.|Multifunctional Biomaterials for Medicine, Helmholtz Virtual Institute , Kantstrasse 55, 14513 Teltow-Seehof, Germany.|Department of Biointerface Science & Technology, Max-Planck Institute for Medical Research , Heisenbergstrasse 3, 70569 Stuttgart, Germany.
authors.forename: Qiang
authors.identifier: http://orcid.org/0000-0001-5194-8262
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Institute of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.|Multifunctional Biomaterials for Medicine, Helmholtz Virtual Institute , Kantstrasse 55, 14513 Teltow-Seehof, Germany.
authors.forename: Rainer
authors.identifier: http://orcid.org/0000-0003-3840-162X
authors.initials: R
authors.lastname: Haag
mesh_terms: D000327:Adsorption; D000818:Animals; D057219:Biofouling; D049872:Bivalvia; D001798:Blood Proteins / Q000737:chemistry*; D011108:Polymers; D013499:Surface Properties
chemical_list: D001798:Blood Proteins; D011108:Polymers
keywords: biofunctional surface; bioinspiration; block copolymer; monolayer; universal coatings