title: Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges.
abstract: Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhage in preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yun Sil
authors.initials: YS
authors.lastname: Chang
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: So Yoon
authors.initials: SY
authors.lastname: Ahn
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Sein
authors.initials: S
authors.lastname: Sung
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wonspark@skku.edu.
authors.forename: Won Soon
authors.initials: WS
authors.lastname: Park
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000628:therapy*; D002543:Cerebral Hemorrhage / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007231:Infant, Newborn; D007234:Infant, Premature; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends
keywords: Mesenchymal stem cells; bronchopulmonary dysplasia; hypoxic ischemic encephalopathy; intraventricular hemorrhage; newborn