title: Colokinetic effect of somatostatin in the spinal defecation center in rats.
abstract: Somatostatin and its receptors are expressed in the spinal cord, but the functional roles of the peptide remain unknown. In this study, we examined the colokinetic effect of somatostatin in the spinal defecation center in anesthetized rats. Intrathecal application of somatostatin into the lumbo-sacral cord caused propulsive contractions of the colorectum. However, somatostatin administered intravenously or intrathecally to the thoracic cord failed to enhance colorectal motility. Transection of the thoracic cord had no significant impact on the colokinetic action of somatostatin. The enhancement of colorectal motility by intrathecal administration of somatostatin was abolished by severing the pelvic nerves. Our results demonstrate that somatostatin acting on the spinal defecation center causes propulsive motility of the colorectum in rats. Considering that somatostatin is involved in nociceptive signal transmission in the spinal cord, our results provide a rational explanation for the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients.
authors.affiliation: Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
authors.forename: Kiyotada
authors.initials: K
authors.lastname: Naitou
authors.affiliation: Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Shiina
authors.affiliation: Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamori
authors.affiliation: Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Sano
authors.affiliation: Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shimaoka
authors.affiliation: Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan. yshimizu@gifu-u.ac.jp.|Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), Gifu, Japan. yshimizu@gifu-u.ac.jp.
authors.forename: Yasutake
authors.initials: Y
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D003106:Colon / Q000187:drug effects; D003672:Defecation / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects; D007278:Injections, Spinal / Q000379:methods; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*
chemical_list: D013004:Somatostatin
keywords: Autonomic nervous system; Blood pressure; GI motility; Irritable bowel syndrome; Large intestine; SRIF