title: Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments.
abstract: Advances in electronics and life sciences have generated interest in "lab-on-a-chip" systems utilizing complementary metal oxide semiconductor (CMOS) circuitry for low-power, portable, and cost-effective biosensing platforms. Here, we present a simple and reliable approach for coating "high-κ" metal oxide dielectric materials with "non-fouling" (protein- and cell-resistant) poly(oligo(ethylene glycol) methyl ether methacrylate (POEGMA) polymer brushes as biointerfacial coatings to improve their relevance for biosensing applications utilizing advanced electronic components. By using a surface-initiated "grafting from" strategy, POEGMA films were reliably grown on each material, as confirmed by ellipsometric measurements and X-ray photoelectron spectroscopy (XPS) analysis. The electrical behavior of these POEGMA films was also studied to determine the potential impact on surrounding electronic devices, yielding information on relative permittivity and breakdown field for POEGMA in both dry and hydrated states. We show that the incorporation of POEGMA coatings significantly reduced levels of nonspecific protein adsorption compared to uncoated high-κ dielectric oxide surfaces as shown by protein resistance assays. These attributes, combined with the robust dielectric properties of POEGMA brushes on high-κ surfaces open the way to incorporate this protein and cell resistant polymer interface into CMOS devices for biomolecular detection in a complex liquid milieu.
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Daniel Y
authors.initials: DY
authors.lastname: Joh
authors.affiliation: Department of Electrical and Computer Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Felicia
authors.initials: F
authors.lastname: McGuire
authors.affiliation: Department of Mechanical Engineering and Materials Science, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Abedini-Nassab
authors.affiliation: Department of Electrical and Computer Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Andrews
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Rohan K
authors.initials: RK
authors.lastname: Achar
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Zackary
authors.initials: Z
authors.lastname: Zimmers
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Darush
authors.initials: D
authors.lastname: Mozhdehi
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Blair
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Faris
authors.initials: F
authors.lastname: Albarghouthi
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: William
authors.initials: W
authors.lastname: Oles
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Jacob
authors.initials: J
authors.lastname: Richter
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Cassio M
authors.initials: CM
authors.lastname: Fontes
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Angus M
authors.initials: AM
authors.lastname: Hucknall
authors.affiliation: Department of Mechanical Engineering and Materials Science, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Yellen
authors.affiliation: Department of Electrical and Computer Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.|Department of Chemistry, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Franklin
authors.affiliation: Department of Biomedical Engineering, Pratt School of Engineering, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Chilkoti
keywords: POEGMA; biointerface; breakdown; capacitance−voltage; metal oxide dielectric; nonfouling; permittivity; polymer brush