title: Trajectory of disability and quality-of-life in non-geriatric and geriatric survivors after severe traumatic brain injury.
abstract: The objective was to investigate disability and health-related quality-of-life (HRQoL) 3, 6 and 12 months after traumatic brain injury (TBI) in non-geriatric (≤ 65 years) and geriatric patients (> 65 years).
  
  
  
  Patients ≥ 16 years who sustained a severe TBI (Abbreviated Injury Scale of the head region > 3) were included in this prospective, multi-centre study. Outcome measures were Glasgow Outcome Scale Extended (GOSE; disability), SF-12 (HRQoL). Mixed linear model analyses were performed.
  
  
  
  Three hundred and fifty-one patients (median age = 50 years; interquartile range (IQR) = 27-67) were included; 73.2% were male and 27.6% were geriatric patients. Median GOSE at 3, 6 and 12 months was 5 (IQR = 3-7), 6 (IQR = 4-8) and 7 (IQR = 5-8); this increase (slopetime= 0.22, p < 0.0001) was age dependent (slopeage*time= -0.06, p = 0.003). Median SF-12 physical component scale score at 3, 6 and 12 months was 42.1 (IQR = 33.6-50.7), 46.6 (IQR = 37.4-53.9) and 50.4 (IQR = 39.2-55.1); this increase (slopetime= 1.52, p < 0.0001) was not age dependent (slopeage*time= -0.30, p = 0.083). SF-12 mental component scale scores were unchanged.
  
  
  
  Disability decreased and HRQoL improved after TBI between 3-12 months. In geriatric patients this improvement was relevant for HRQoL only.
authors.affiliation: a Department of Psychology , Harvard University, Cambridge , Boston , MA , USA.|b Division of Public Psychiatry , Massachusetts Mental Health Center , Boston , MA , USA.
authors.forename: Chiara S
authors.initials: CS
authors.lastname: Haller
authors.affiliation: c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland.
authors.forename: Cecile
authors.initials: C
authors.lastname: Delhumeau
authors.affiliation: c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: De Pretto
authors.affiliation: d Division of Cognitive and Restorative Neurology, Department of Neurology , Inselspital, Bern University Hospital, and University of Bern , Bern , Switzerland.
authors.forename: Rahel
authors.initials: R
authors.lastname: Schumacher
authors.affiliation: e Psychiatric Service Aargau , Windisch , Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Pielmaier
authors.affiliation: f Department of Clinical Psychology , University of Geneva , Geneva , Switzerland.
authors.forename: Marie My Lien
authors.initials: MM
authors.lastname: Rebetez
authors.affiliation: c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland.|g Division of Clinical Epidemiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland.
authors.forename: Guy
authors.initials: G
authors.lastname: Haller
authors.affiliation: c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Walder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D000070642:Brain Injuries, Traumatic / Q000401:mortality / Q000503:physiopathology / Q000523:psychology; D015331:Cohort Studies; D006233:Persons with Disabilities / Q000523:psychology*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D013997:Time Factors; D055815:Young Adult
keywords: Head injury; elderly; functional outcome; health-related quality-of-life; recovery