title: Sinus bradycardia after intravenous pulse methylprednisolone therapy in patients with systemic lupus erythematosus.
abstract: Sinus bradycardia is reported as an adverse effect of high-dose glucocorticoid therapy. We report three cases of systemic lupus erythematosus, wherein intravenous pulse methylprednisolone was administered. The patients' average baseline heart rate was 72 beats/min, which decreased 30% from baseline at 61 h after beginning the therapy. The average minimum heart rate was 38 beats/min, and this rate continued for 169 h on average. No other causes for bradycardia were found, suggesting that the administration of glucocorticoid pulse therapy resulted in decreased heart rate.
authors.affiliation: a Department of Allergy and Rheumatology , University of Tokyo , Tokyo , Japan.|b Department of Rheumatic Diseases , Tama-Hokubu Medical Center, Health and Medical Treatment Corporation , Tokyo , Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Ohshima
authors.affiliation: a Department of Allergy and Rheumatology , University of Tokyo , Tokyo , Japan.|c Department of Rheumatology , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Kimito
authors.initials: K
authors.lastname: Kawahata
authors.affiliation: a Department of Allergy and Rheumatology , University of Tokyo , Tokyo , Japan.|d Department of Immunotherapy Management , Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kanda
authors.affiliation: a Department of Allergy and Rheumatology , University of Tokyo , Tokyo , Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D001919:Bradycardia / Q000209:etiology*; D066126:Cardiotoxicity; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008775:Methylprednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D012804:Sick Sinus Syndrome / Q000209:etiology*
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: SLE; Sinus bradycardia; glucocorticoid pulse therapy