title: [Mechanisms of mitochondrial transport and distribution within the cell].
abstract: Mitochondria are multifunctional, dynamic organelles, which are continuously undergoing fusion and fission and are actively distributed within the cell. Mitochondria travel along microtubules together with a mitochondrial trafficking complex, formed by motor and adaptor proteins. Proper mitochondrial movements are crucial for neurons, in which mitochondria translocate in two directions. Anterograde transport is an outward movement of mitochondria from the cell body to the synapse, whereas retrograde is an inward movement away from the synapse or plasma membrane toward the cell body. This article presents a summary of current knowledge about the intracellular transport of mitochondria and its regulation in mammalian cells.
authors.affiliation: Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warszawa, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Drabik
authors.affiliation: Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warszawa, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Malińska
authors.affiliation: Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warszawa, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Duszyński
authors.affiliation: Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warszawa, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Szczepanowska
mesh_terms: D000818:Animals; D001692:Biological Transport; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology
keywords: mitochondrial transport; regulation of mitochondrial distribution.; trafficking complex