title: Infectious Zika virus in vaginal secretions from an HIV-infected woman, France, August 2016.
abstract: A woman with controlled HIV infection developed in late August 2016 a pruritic rash with fever and conjunctival hyperaemia after a trip to the French Caribbean islands. On day 3 after symptom onset, Zika virus RNA was detected in plasma, urine and vaginal samples with respective viral loads of 3.8, 6.1 and 5.3 log copies/mL. Notably, we demonstrated the presence of infectious Zika virus particles in the vaginal samples by isolation in cell culture.
authors.affiliation: Internal Medicine and Infectious Diseases Department, Andre Gregoire Hospital, Montreuil, France.|Infectious and Tropical Diseases Department, Saint Louis Hospital, Paris, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Penot
authors.affiliation: Clinical Microbiology Department, Avicenne Hospital, Bobigny, France.
authors.forename: Ségolène
authors.initials: S
authors.lastname: Brichler
authors.affiliation: Family Planning Clinic, Saint Louis Hospital, Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Guilleminot
authors.affiliation: Infectious and Tropical Diseases Department, Saint Louis Hospital, Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lascoux-Combe
authors.affiliation: Internal Medicine Department, Saint Louis hospital, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Taulera
authors.affiliation: Clinical Microbiology Department, Avicenne Hospital, Bobigny, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gordien
authors.affiliation: Institut de Recherche Biomédicale des Armées, National Reference Laboratory for arboviruses, Marseille, France.|UMR 'Emergence des Pathologies Virales' (EPV Aix Marseille university, IRD French Institute of Research for Development, INSERM French National Institute of Health and Medical Research, EHESP French School of Public Health), Marseille, France.|These authors contributed equally to this work.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Leparc-Goffart
authors.affiliation: Infectious and Tropical Diseases Department, Saint Louis Hospital, Paris, France.|These authors contributed equally to this work.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Molina
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001826:Body Fluids / Q000821:virology*; D005260:Female; D005334:Fever / Q000821:virology*; D005602:France; D019430:Guadeloupe; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008395:Martinique; D063806:Myalgia / Q000209:etiology; D012367:RNA, Viral / Q000097:blood / Q000652:urine; D014195:Travel; D014621:Vagina / Q000821:virology*; D000071244:Zika Virus / Q000235:genetics / Q000302:isolation & purification*; D000071243:Zika Virus Infection / Q000175:diagnosis* / Q000821:virology
chemical_list: D012367:RNA, Viral
keywords: Zika virus; imported viral disease; sexually transmitted infections; vector-borne infections