title: Preparation and evaluation of metoprolol tartrate sustained-release pellets using hot melt extrusion combined with hot melt coating.
abstract: The objective of this study was to prepare and evaluate metoprolol tartrate sustained-release pellets. Cores were prepared by hot melt extrusion and coated pellets were prepared by hot melt coating. Cores were found to exist in a single-phase state and drug in amorphous form. Plasticizers had a significant effect on torque and drug content, while release modifiers and coating level significantly affected the drug-release behavior. The mechanisms of drug release from cores and coated pellets were Fickian diffusion and diffusion-erosion. The coated pellets exhibited sustained-release properties in vitro and in vivo.
authors.affiliation: a School of Pharmacy, Zhejiang University of Technology , Hangzhou , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a School of Pharmacy, Zhejiang University of Technology , Hangzhou , China.
authors.forename: Lian
authors.initials: L
authors.lastname: Shen
authors.affiliation: a School of Pharmacy, Zhejiang University of Technology , Hangzhou , China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: a School of Pharmacy, Zhejiang University of Technology , Hangzhou , China.
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Shan
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004058:Diffusion; D004339:Drug Compounding; D005079:Excipients; D007700:Kinetics; D008790:Metoprolol / Q000008:administration & dosage*; D010968:Plasticizers; D012995:Solubility
chemical_list: D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D005079:Excipients; D010968:Plasticizers; D008790:Metoprolol
keywords: Metoprolol tartrate; drug-release mechanism; hot melt coating; hot melt extrusion; sustained-release pellets