title: Acetic Acid Enhanced Narrow Band Imaging for the Diagnosis of Gastric Intestinal Metaplasia.
abstract: Gastric intestinal metaplasia (GIM) is a precancerous lesion of the stomach. The detection of GIM using conventional white-light endoscopy (WLE) is difficult. In this study, we determined whether acetic acid-enhanced narrow band imaging (AA-NBI) improves the detection of GIM. A consecutive cohort of 132 individuals aged 40 years or older was subjected to upper gastrointestinal endoscopy using WLE, NBI and AA-NBI. The ability of the three methods to diagnose GIM in patients was compared. Histological assessment (per-patient and per-biopsy) was used for the accuracy assessment. Sixty-six (50.0%) out of the 132 individuals examined were found to have GIM, of which 44 (66.7%) were diagnosed correctly by NBI (sensitivity 66.7% and specificity 68.2%) and 58 (87.9%) were correctly identified by AA-NBI (sensitivity 87.9% and specificity 68.2%), as compared to only 22 (33.3%) by WLE (sensitivity 33.3% and specificity 28.8%). Therefore, the sensitivity of AA-NBI in the diagnosis of GIM was significantly higher than NBI (p<0.05) and WLE (p < 0.001). Our study indicates that AA-NBI can improve the accuracy of endoscopy-targeted biopsies for GIM.
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.|Department of Gastroenterology, Jingjiang People's Hospital, Jingjiang, Jiangsu, China.
authors.forename: Jie
authors.identifier: http://orcid.org/0000-0003-4071-7244
authors.initials: J
authors.lastname: Sha
authors.affiliation: Department of Gastroenterology, Drum Tower Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Jingjiang People's Hospital, Jingjiang, Jiangsu, China.
authors.forename: Bingliang
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Jingjiang People's Hospital, Jingjiang, Jiangsu, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Xueliang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Jingjiang People's Hospital, Jingjiang, Jiangsu, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
mesh_terms: D019342:Acetic Acid / Q000737:chemistry*; D000328:Adult; D001706:Biopsy; D003710:Demography; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods*; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D015203:Reproducibility of Results; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D019342:Acetic Acid