title: Liver physiological polyploidization: MicroRNA-122 a key regulator.
abstract: Polyploidy is defined as an increase in genome DNA content and is observed in all mammalian species. Polyploidy is a common characteristic of hepatocytes. Polyploidization occurs mainly during liver development, but also in adults with increasing age or due to cellular stress. During liver development, hepatocytes polyploidization occurs through cytokinesis failure leading to the genesis of binucleate hepatocytes. Recently, Hsu et al. demonstrated that miR-122 is a key regulator of hepatic binucleation. In fact, during liver development, miR-122 directly antagonizes procytokinesis targets and thus induces cytokinesis failure leading to the genesis of binucleate hepatocytes.
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France; CNRS, UMR 8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Celton-Morizur
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France; CNRS, UMR 8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: chantal.desdouets@inserm.fr.
authors.forename: Chantal
authors.initials: C
authors.lastname: Desdouets
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D022781:Hepatocytes / Q000648:ultrastructure*; D006801:Humans; D008099:Liver / Q000254:growth & development / Q000648:ultrastructure*; D035683:MicroRNAs / Q000502:physiology*; D011123:Polyploidy
chemical_list: C531907:MIRN122 microRNA, human; D035683:MicroRNAs; C544354:Mirn122 microRNA, mouse