title: [A Case of Gastrointestinal Stromal Tumor(GIST)Originating in the Anal Canal].
abstract: We report a case of a gastrointestinal stromal tumor(GIST)that originated in the anal canal. A 70's woman with a subcutaneous tumor reaching from the anal canal was referred to our hospital. After a thorough examination, the tumor was resected percutaneously in the jackknife position. Histopathological examination showed proliferation of spindle-shaped tumor cells arranged in irregular bundles. Immunohistochemical staining showed that the tumor was positive for c-kit and CD34, and negative for a-SMA and S-100, so the tumor was diagnosed as GIST. As a-SMA-positive smooth muscle cells were seen around the tumor, we suspected that this tumor originated from the internal sphincter muscle.
authors.affiliation: Dept. of Surgery, Toyama City Hospital.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Terada
authors.forename: Akemi
authors.initials: A
authors.lastname: Yoshikawa
authors.forename: Shogo
authors.initials: S
authors.lastname: Maruzen
authors.forename: Yasumichi
authors.initials: Y
authors.lastname: Yagi
authors.forename: Shozo
authors.initials: S
authors.lastname: Sasaki
authors.forename: Wataru
authors.initials: W
authors.lastname: Fukushima
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
authors.forename: Ryohei
authors.initials: R
authors.lastname: Izumi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use; D009154:Mutation; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit