title: Disseminated Autochthonous Dermal Leishmaniasis Caused byLeishmania siamensis(PCM2 Trang) in a Patient from Central Thailand Infected with Human Immunodeficiency Virus.
abstract: AbstractSeveral case reports of autochthonous leishmaniasis in Thailand have been published since 1996. Most of the previous cases presented with visceral leishmaniasis (VL) and were mostly reported in southern part of Thailand. Recently, it has been evident thatLeishmania martiniquensisis the main cause ofLeishmaniainfection in Thailand. However,Leishmania siamensis(PCM2 Trang isolate) was found to be of a separate lineage with restricted distribution in southern Thailand and also a cause of disseminated dermal and visceral leishmaniasis in one published case. Here we report the first patient from central Thailand with human immunodeficiency virus infection presenting with disseminated dermal leishmaniasis. Polymerase chain reaction and DNA sequencing analysis (large subunit of RNA polymerase II and 18S ribosomal RNA internal transcribed spacer 1) from the tissue biopsy sample revealed the pathogen sequences to be highly homologous to PCM2 Trang strain previously reported from southern Thailand.
authors.affiliation: Department of Medical Services, Ministry of Public Health, Institute of Dermatology, Bangkok, Thailand.
authors.forename: Chavalit
authors.initials: C
authors.lastname: Supsrisunjai
authors.affiliation: Department of Medical Services, Ministry of Public Health, Institute of Dermatology, Bangkok, Thailand.
authors.forename: Tanawatt
authors.initials: T
authors.lastname: Kootiratrakarn
authors.affiliation: Department of Medical Services, Ministry of Public Health, Institute of Dermatology, Bangkok, Thailand.
authors.forename: Pailin
authors.initials: P
authors.lastname: Puangpet
authors.affiliation: Department of Medical Services, Ministry of Public Health, Institute of Dermatology, Bangkok, Thailand.
authors.forename: Thareena
authors.initials: T
authors.lastname: Bunnag
authors.affiliation: Department of Medical Services, Ministry of Public Health, Institute of Dermatology, Bangkok, Thailand.
authors.forename: Prapaipit
authors.initials: P
authors.lastname: Chaowalit
authors.affiliation: Department of Medical Services, Ministry of Public Health, Institute of Dermatology, Bangkok, Thailand.
authors.forename: Vesarat
authors.initials: V
authors.lastname: Wessagowit
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D020405:Dermis / Q000187:drug effects / Q000469:parasitology / Q000473:pathology* / Q000821:virology; D005260:Female; D006678:HIV / Q000187:drug effects / Q000254:growth & development; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007891:Leishmania / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D016774:Leishmaniasis, Diffuse Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D015800:Protozoan Proteins / Q000235:genetics; D012319:RNA Polymerase II / Q000235:genetics; D017422:Sequence Analysis, DNA; D013785:Thailand
chemical_list: D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D021903:DNA, Ribosomal Spacer; D015800:Protozoan Proteins; D017964:Itraconazole; D000666:Amphotericin B; D012319:RNA Polymerase II