title: Risk of travel-related cases of Zika virus infection is predicted by transmission intensity in outbreak-affected countries.
abstract: Zika virus (ZIKV) infection is emerging globally, currently causing outbreaks in the Caribbean, and Central and South America, and putting travellers to affected countries at risk. Model-based estimates for the basic reproduction number (R0) of ZIKV in affected Caribbean and Central and South American countries, obtained from 2015 to 2016 human case surveillance data, were compared by logistic regression and Receiver-Operating Characteristic (ROC), with the prevalence of ZIKV-positive test results in Canadians who travelled to them.
  
  
  
  Estimates of R0for each country were a good predictor of the ZIKV test result (ROC area under the curve = 0.83) and the odds of testing positive was 11-fold greater for travellers visiting countries with estimated R0≥ 2.76, compared to those visiting countries with R0< 2.76.
  
  
  
  Risk to travellers varies widely amongst countries affected by ZIKV outbreaks. Estimates of R0from surveillance data can assist in assessing levels of risk for travellers and may help improve travel advice. They may also allow better prediction of spread of ZIKV from affected countries by travellers.
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, rue Sicotte, Saint-Hyacinthe, Québec, Canada. nicholas.ogden@phac-aspc.gc.ca.
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Ogden
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Research Lane, Guelph, ON, Canada.
authors.forename: Aamir
authors.initials: A
authors.lastname: Fazil
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Arlington Rd., Winnipeg, MB, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Safronetz
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Arlington Rd., Winnipeg, MB, Canada.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Drebot
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Research Lane, Guelph, ON, Canada.
authors.forename: Justine
authors.initials: J
authors.lastname: Wallace
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, rue Sicotte, Saint-Hyacinthe, Québec, Canada.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Rees
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Arlington Rd., Winnipeg, MB, Canada.
authors.forename: Kristina
authors.initials: K
authors.lastname: Decock
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Research Lane, Guelph, ON, Canada.
authors.forename: Victoria
authors.initials: V
authors.lastname: Ng
mesh_terms: D000569:Americas / Q000453:epidemiology; D050936:Basic Reproduction Number; D004196:Disease Outbreaks; D018562:Disease Transmission, Infectious; D006801:Humans; D018570:Risk Assessment; D014195:Travel; D000076082:Travel-Related Illness; D000071243:Zika Virus Infection / Q000453:epidemiology*
keywords: Basic reproduction number; Risk; Travellers; Zika virus