title: A Red Carpet for Iron Metabolism.
abstract: 200 billion red blood cells (RBCs) are produced every day, requiring more than 2 × 1015iron atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 mL of blood being produced each day, containing 6 g of hemoglobin and 20 mg of iron. These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.
authors.affiliation: Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany.
authors.forename: Martina U
authors.initials: MU
authors.lastname: Muckenthaler
authors.affiliation: Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA.
authors.forename: Stefano
authors.initials: S
authors.lastname: Rivella
authors.affiliation: Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany; European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Electronic address: hentze@embl.de.
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Hentze
authors.affiliation: Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
authors.forename: Bruno
authors.initials: B
authors.lastname: Galy
mesh_terms: D000740:Anemia / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D041905:Erythroid Cells / Q000378:metabolism*; D004920:Erythropoiesis; D064451:Hepcidins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D019266:Iron, Dietary / Q000378:metabolism
chemical_list: D064451:Hepcidins; D019266:Iron, Dietary; D007501:Iron