title: Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding.
abstract: A general method for sequence-specific binding of peptides remains elusive despite decades of research. By creating an array of "hydrophobically coded dimples" on the surface of surface-core doubly cross-linked micelles, we synthesized water-soluble nanoparticle receptors to recognize peptides by the location, number, and nature of their hydrophobic side chains. Minute differences in the side chains could be distinguished, and affinities up to 20 nM were obtained for biologically active oligopeptides in water.
authors.affiliation: Department of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
authors.forename: Joseph K
authors.identifier: 0000-0003-3710-3014
authors.initials: JK
authors.lastname: Awino
authors.affiliation: Department of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
authors.forename: Roshan W
authors.initials: RW
authors.lastname: Gunasekara
authors.affiliation: Department of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
authors.forename: Yan
authors.identifier: 0000-0003-1215-2565
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D001665:Binding Sites; D057927:Hydrophobic and Hydrophilic Interactions; D008968:Molecular Conformation; D054802:Molecular Imprinting; D053758:Nanoparticles / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; D014867:Water