title: β-Amino functionalization of cinnamic Weinreb amides in ionic liquid.
abstract: 2-Ns-Protected β-amino Weinreb amides were synthesized by aminochlorination of α,β-unsaturated Weinreb amides in an ionic liquid, 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([BMIM][NTf2]). Processed without the use of metal catalysts or the need of an inert gas atmosphere, the presented process can be readily performed as a one-pot synthesis at room temperature. Moreover, the preparation has the distinct advantages of the use of 2-NsNCl2as an inexpensive and stable nitrogen/halogen source and the ionic liquid as a recyclable reaction media. Nine examples were examined, and modest to good isolated chemical yields (40-83%) were obtained.
authors.affiliation: School of Chemistry & Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Wang
authors.affiliation: School of Chemistry & Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China.
authors.forename: Guo-Xiang
authors.initials: GX
authors.lastname: Sun
authors.affiliation: School of Chemistry & Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Qi
keywords: Weinreb amides; aminochlorination; ionic liquid; β-amino functionalization