title: Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review.
abstract: The mechanisms of antioxidant activities of phytochemicals are highly complex, so various methods to study them have been developed. However, the diverse available methods show inconsistent results. Different stressors, cell models, and animal models have been used to evaluate the antioxidant properties of phytochemicals. However, the literature still lacks a summary of the effects of different stressors, cell models, and animal models on the evaluation of antioxidant activities. Therefore, the mechanisms of action of different oxidative stimuli and the characteristics of the available cell models and animal models are summarized in this review.
authors.affiliation: Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yin
authors.affiliation: Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.
authors.forename: Lianyan
authors.initials: L
authors.lastname: Huang
authors.affiliation: Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.|Beijing Engineering and Technology Research Center of Food Additives, Beijing, 100048, China.|Key Laboratory of Space Nutrition and Food Engineering, Beijing, 100094, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.
authors.forename: Lingxiao
authors.initials: L
authors.lastname: Gong
authors.affiliation: Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.
authors.forename: Baoguo
authors.initials: B
authors.lastname: Sun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D023421:Models, Animal; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts
keywords: animal studies; antioxidant activities; cell models; evaluation