title: Insight into potential mechanisms of hypobaric hypoxia-induced learning and memory deficit - Lessons from rat studies.
abstract: Impairment of memory is one of the most frequently reported symptoms during sudden hypoxia exposure in human. Cortical atrophy has been linked to the impaired memory function and is suggested to occur with chronic high-altitude exposure. However, the precise molecular mechanism(s) of hypoxia-induced memory impairment remains an enigma. In this work, we review hypoxia-induced learning and memory deficit in human and rat studies. Based on data from rat studies using different protocols of continuous hypoxia, we try to elicit potential mechanisms of hypobaric hypoxia-induced memory deficit.
authors.affiliation: 1 Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Eya
authors.initials: E
authors.lastname: Qaid
authors.affiliation: 1 Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: R
authors.initials: R
authors.lastname: Zakaria
authors.affiliation: 2 School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia.
authors.forename: S F
authors.initials: SF
authors.lastname: Sulaiman
authors.affiliation: 3 Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Na Mohd
authors.initials: NM
authors.lastname: Yusof
authors.affiliation: 1 Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: N
authors.initials: N
authors.lastname: Shafin
authors.affiliation: 4 Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Z
authors.initials: Z
authors.lastname: Othman
authors.affiliation: 1 Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: A H
authors.initials: AH
authors.lastname: Ahmad
authors.affiliation: 1 Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: Cb Abd
authors.initials: CA
authors.lastname: Aziz
mesh_terms: D000818:Animals; D000860:Hypoxia; D007858:Learning / Q000502:physiology*; D010100:Oxygen; D051381:Rats
chemical_list: D010100:Oxygen
keywords: High altitude; hypoxia; learning; memory; rats