title: Lipophilic teicoplanin pseudoaglycon derivatives are active against vancomycin- and teicoplanin-resistant enterococci.
abstract: A selection of nine derivatives of teicoplanin pseudoaglycon were tested in vitro against clinical vancomycin-resistant Enterococcus strains possessing vanA, vanB or both genes. The bacteria were characterized by PCR for the identification of their resistance genes. The tested compounds contain lipoic acid, different carbohydrates and aryl groups as lipophilic moieties. About one-third of the teicoplanin-resistant strains were shown to be susceptible to one or more of the glycopeptide derivatives.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Szűcs
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Ilona
authors.initials: I
authors.lastname: Bereczki
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Magdolna
authors.initials: M
authors.lastname: Csávás
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Rőth
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Anikó
authors.initials: A
authors.lastname: Borbás
authors.affiliation: Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Batta
authors.affiliation: Department of Medical Microbiology, Semmelweis University, Budapest, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Ostorházi
authors.affiliation: Department of Medical Microbiology, Semmelweis University, Budapest, Hungary.
authors.forename: Réka
authors.initials: R
authors.lastname: Szatmári
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Pál
authors.initials: P
authors.lastname: Herczegh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D019729:Carbon-Oxygen Ligases / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016983:Enterococcus / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D017334:Teicoplanin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C071437:VanA ligase, Bacteria; C079913:VanB protein, Enterococcus; D017334:Teicoplanin; D014640:Vancomycin; D019729:Carbon-Oxygen Ligases