title: An unexpected response to second line EGFR inhibitor in relapsing leptomeningeal carcinomatosis from lung adenocarcinoma raises questions on differential mechanisms of action of these agents.
authors.affiliation: Hotel-Dieu de France university hospital, Saint-Joseph university, faculty of medicine, department of hematology-oncology, Beirut, Lebanon.
authors.forename: Marwan
authors.initials: M
authors.lastname: Ghosn
authors.affiliation: Hotel-Dieu de France university hospital, Saint-Joseph university, faculty of medicine, department of hematology-oncology, Beirut, Lebanon. Electronic address: tarekassi@gmail.com.
authors.forename: Tarek
authors.initials: T
authors.lastname: Assi
authors.affiliation: Hotel-Dieu de France university hospital, Saint-Joseph university, faculty of medicine, department of hematology-oncology, Beirut, Lebanon.
authors.forename: Elie
authors.initials: E
authors.lastname: El Rassy
authors.affiliation: Hotel-Dieu de France university hospital, Saint-Joseph university, faculty of medicine, department of hematology-oncology, Beirut, Lebanon.
authors.forename: Tania
authors.initials: T
authors.lastname: Moussa
authors.affiliation: Hotel-Dieu de France university hospital, Saint-Joseph university, faculty of medicine, department of hematology-oncology, Beirut, Lebanon.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kattan
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D000077716:Afatinib; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics; D000069347:Erlotinib Hydrochloride / Q000008:administration & dosage*; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D008297:Male; D055756:Meningeal Carcinomatosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D011799:Quinazolines / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D000077716:Afatinib; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors; D000077156:Gefitinib
keywords: Adénocarcinome pulmonaire; Afatinib; Anti-EGFR; Carcinomatose leptoméningée; Erlotinib; Leptomeningeal carcinomatosis; Lung adenocarcinoma