title: Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.
abstract: The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.|Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Assaf
authors.initials: A
authors.lastname: Ramot
authors.affiliation: Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Texas, USA.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston, Texas, USA.
authors.forename: Jin-Bin
authors.initials: JB
authors.lastname: Tian
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.|Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Tali
authors.initials: T
authors.lastname: Nahum
authors.affiliation: Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Kuperman
authors.affiliation: Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Texas, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Justice
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.|Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Alon
authors.initials: A
authors.lastname: Chen
mesh_terms: D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology / Q000502:physiology; D003348:Cortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008124:Locomotion / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D000099052:CRF Receptor, Type 1
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1; D003346:Corticotropin-Releasing Hormone; D003348:Cortisone