title: Continuous-flow synthesis of primary amines: Metal-free reduction of aliphatic and aromatic nitro derivatives with trichlorosilane.
abstract: The metal-free reduction of nitro compounds to amines mediated by trichlorosilane was successfully performed for the first time under continuous-flow conditions. Aromatic as well as aliphatic nitro derivatives were converted to the corresponding primary amines in high yields and very short reaction times with no need for purification. The methodology was also extended to the synthesis of two synthetically relevant intermediates (precursors of baclofen and boscalid).
authors.affiliation: Dipartimento di Chimica, Università di Milano, Via Golgi 19, 20133, Milano, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Porta
authors.affiliation: Dipartimento di Chimica, Università di Milano, Via Golgi 19, 20133, Milano, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Puglisi
authors.affiliation: Dipartimento di Chimica, Università di Milano, Via Golgi 19, 20133, Milano, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Colombo
authors.affiliation: Dipartimento di Chimica, Università di Milano, Via Golgi 19, 20133, Milano, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rossi
authors.affiliation: Dipartimento di Chimica, Università di Milano, Via Golgi 19, 20133, Milano, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Benaglia
keywords: chemoselectivity; continuous processes; flow synthesis; nitro reduction; trichlorosilane