title: Prognostic Impact of Different Histological Types on Gastric Adenocarcinoma: a Surveillance, Epidemiology, and End Results Database Analysis.
abstract: The clinicopathological characteristics and prognosis of gastric mucinous adenocarcinoma (MAC) and signet ring cell carcinoma (SRC) are still controversial. We designed our study to evaluate the clinicopathologic features and prognosis of MAC, SRC and ordinary gastric adenocarcinoma (OGAC) by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database. The 5-year overall survival (OS) of patients with SRC was significantly lower than that of patients with MAC (P = 0.001) and OGAC (P < 0.001), and there was no significant difference in 5-year OS between MAC and OGAC (P = 0.804). Furthermore, there were no significant differences of 5-years OS among these three groups at stage I, II and III (all P > 0.05) and no significant difference between MAC and OGAC at stage IV (P = 0.110). Patients in SRC group had significantly worse survival than those in MAC and OGAC at stage IV (both P = 0.008), with 5-year OS of 3.3%, 5.8%, and 5.8%, respectively. However, the histological type was not found to be an independent prognostic factor of gastric cancer according to the multivariate analysis with Cox regression.
authors.affiliation: Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, No. 57, Xing'Ning Road, Ningbo, 315041, China.
authors.forename: Kaitai
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Juefeng
authors.initials: J
authors.lastname: Wan
authors.affiliation: Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, No. 57, Xing'Ning Road, Ningbo, 315041, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Bei
authors.affiliation: Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, No. 57, Xing'Ning Road, Ningbo, 315041, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, No. 57, Xing'Ning Road, Ningbo, 315041, China. lmz2005@yeah.net.
authors.forename: Miaozhen
authors.initials: M
authors.lastname: Lu
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D018426:SEER Program; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
keywords: Gastric carcinoma; Mucinous adenocarcinoma; SEER; Signet ring cell carcinoma; Survival