title: Chromatin dynamics during the cell cycle at centromeres.
abstract: Centromeric chromatin undergoes major changes in composition and architecture during each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in mitosis to ensure proper chromosome segregation. Thus, proper orchestration of centromeric chromatin dynamics during interphase, including replication in S phase, is crucial. We provide the current view concerning the centromeric architecture associated with satellite repeat sequences in mammals and its dynamics during the cell cycle. We summarize the contributions of deposited histone variants and their chaperones, other centromeric components - including proteins and their post-translational modifications, and RNAs - and we link the expression and deposition timing of each component during the cell cycle. Because neocentromeres occur at ectopic sites, we highlight how cell cycle processes can go wrong, leading to neocentromere formation and potentially disease.
authors.affiliation: Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, F-75005 Paris, France.|Sorbonne Universités, UPMC Université Paris 06, CNRS, UMR3664, F-75005 Paris, France.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Müller
authors.affiliation: Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, F-75005 Paris, France.|Sorbonne Universités, UPMC Université Paris 06, CNRS, UMR3664, F-75005 Paris, France.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Almouzni
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D002503:Centromere / Q000235:genetics*; D002843:Chromatin / Q000235:genetics*; D020090:Chromosome Segregation; D006801:Humans
chemical_list: D002843:Chromatin