title: Radiation-Induced Organizing Pneumonia: A Characteristic Disease that Requires Symptom-Oriented Management.
abstract: Radiation-induced organizing pneumonia (RIOP) is an inflammatory lung disease that is occasionally observed after irradiation to the breast. It is a type of secondary organizing pneumonia that is characterized by infiltrates outside the irradiated volume that are sometimes migratory. Corticosteroids work acutely, but relapse of pneumonia is often experienced. Management of RIOP should simply be symptom-oriented, and the use of corticosteroids should be limited to severe symptoms from the perspective not only of cost-effectiveness but also of cancer treatment. Once steroid therapy is started, it takes a long time to stop it due to frequent relapses. We review RIOP from the perspective of its diagnosis, epidemiology, molecular pathogenesis, and patient management.
authors.affiliation: Department of Radiation Oncology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan. otani-keisuke@umin.org.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Otani
authors.affiliation: Department of Radiation Oncology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan. seo@radonc.med.osaka-u.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Seo
authors.affiliation: Department of Radiation Oncology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan. kogawa@radonc.med.osaka-u.ac.jp.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ogawa
mesh_terms: D000818:Animals; D003663:Decision Trees; D006801:Humans; D011014:Pneumonia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D011832:Radiation Injuries / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*
keywords: breast cancer; bronchiolitis obliterans organizing pneumonia; corticosteroid treatment; organizing pneumonia; radiation-induced organizing pneumonia