title: Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface.
abstract: Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol) (PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding the polar ones. A solvent-accessible-surface-area model of protein adsorption accurately fits a large set of data on the composition of the protein corona of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles recently obtained by label-free proteomic mass spectrometry.
authors.affiliation: Institute of Physics, Johannes Gutenberg University Mainz, Germany. settanni@uni-mainz.de friederike.schmid@uni-mainz.de and Max Planck Graduate Center with the Johannes Gutenberg University Mainz, Germany.
authors.forename: Giovanni
authors.identifier: http://orcid.org/0000-0003-1338-937X
authors.initials: G
authors.lastname: Settanni
authors.affiliation: Institute of Physics, Johannes Gutenberg University Mainz, Germany. settanni@uni-mainz.de friederike.schmid@uni-mainz.de.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Institute of Physics, Johannes Gutenberg University Mainz, Germany. settanni@uni-mainz.de friederike.schmid@uni-mainz.de.
authors.forename: Tongchuan
authors.initials: T
authors.lastname: Suo
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany. mailaend@mpip-mainz.mpg.de and University Medical Center, Dermatology Clinic, Johannes Gutenberg University Mainz, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schöttler
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany. mailaend@mpip-mainz.mpg.de.
authors.forename: Katharina
authors.initials: K
authors.lastname: Landfester
authors.affiliation: Institute of Physics, Johannes Gutenberg University Mainz, Germany. settanni@uni-mainz.de friederike.schmid@uni-mainz.de.
authors.forename: Friederike
authors.initials: F
authors.lastname: Schmid
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany. mailaend@mpip-mainz.mpg.de and University Medical Center, Dermatology Clinic, Johannes Gutenberg University Mainz, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Mailänder
mesh_terms: D000327:Adsorption; D000596:Amino Acids / Q000737:chemistry; D001798:Blood Proteins / Q000737:chemistry*; D006801:Humans; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles; D011092:Polyethylene Glycols; D000066970:Protein Corona / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D001798:Blood Proteins; D000066970:Protein Corona; D011092:Polyethylene Glycols