title: [Pancreatic Cancer with Liver Metastasis Treated with Radical Surgery after Chemotherapy].
abstract: Pancreatic ductal carcinoma is a highly aggressive cancer, and chemotherapy is the standard therapy for pancreatic adenocarcinoma. We report curative resection for a case of pancreatic cancer with liver metastasis after chemotherapy. A 67-yearold woman presented with vomiting and weight loss, and was admitted to our hospital for an evaluation of pancreatic lesions. Computed tomography revealed a hypoattenuating tumor in the head of the pancreas. We would usually perform pancreatoduodenectomy based on a diagnosis of cStage III . However, this case was inoperable because we found 4 liver metastases during surgery, which we resected. Sixteen days after surgery, we administered FOLFIRINOX chemotherapy. The grade 2 toxicities were nausea, anorexia, diarrhea, and fatigue, but serious adverse events did not occur. After 7 courses of chemotherapy, no new metastases were noted. Therefore, radical subtotal stomach-preserving pancreatoduodenectomy was performed. The patient has survived without any recurrence for more than 17 months after hepatectomy.
authors.affiliation: Dept. of Surgery, Kansai Rosai Hospital.
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Katsura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohmura
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Junichi
authors.initials: J
authors.lastname: Inatome
authors.forename: Atsushi
authors.initials: A
authors.lastname: Naito
authors.forename: Kohei
authors.initials: K
authors.lastname: Murakami
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeno
authors.forename: Chiyomi
authors.initials: C
authors.lastname: Egawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tamura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D016896:Treatment Outcome