title: Eosinophilia - associated basal plasmacytosis: an early and sensitive histologic feature of inflammatory bowel disease.
abstract: Basal plasmacytosis is an early-onset and highly predictive feature of inflammatory bowel disease (IBD), but may have several restrictions in routine histology. Considering evidences about cooperation between eosinophils and plasma cells in IBD pathogenesis, we investigated immunostain of these two cells as a marker of disease. 343 samplings from 83 patients (52 IBD, 31 non-IBD colitis) were evaluated. The sections were stained with monoclonal antibodies against plasma cells (CD138 and MUM1), and eosinophils (CD193). Eosinophilia-associated basal plasmacytosis (EBP) was related with the histologic diagnosis of IBD (90.3% IBD and 35.4% non-IBD colitides, p < 0.005, sensitivity 90.4%). A strong relation was detected between the occurrence of EBP and (i) the achieving of a complete endoscopic mapping; (ii) the presence of other characteristic lesions of IBD in single segmental sampling, although EBP was evident in more than 40% of samples without other IBD-related lesions. EBP is a sensitive histologic feature of IBD, especially at the first endoscopic sampling, even in the absence of the other characteristic histologic lesions, and may help in formulating a more precise diagnosis in this setting.
authors.affiliation: Pathology Department, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Canavese
authors.affiliation: Institute of Pathology, Spedali Civili di Brescia, Brescia, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Villanacci
authors.affiliation: Gastroenterology Unit, Perugia General Hospital, Perugia, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Antonelli
authors.affiliation: Institute of Pathology, Spedali Civili di Brescia, Brescia, Italy.
authors.forename: Moris
authors.initials: M
authors.lastname: Cadei
authors.affiliation: Pathology Department, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Sapino
authors.affiliation: Gastroenterology Department, Ospedale Mauriziano, Torino, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Rocca
authors.affiliation: Gastroenterology Department, Ospedale Mauriziano, Torino, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Daperno
authors.affiliation: Gastroenterology Department, Ospedale Mauriziano, Torino, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Suriani
authors.affiliation: Pathology Department, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Italy.
authors.forename: Maria Giulia
authors.initials: MG
authors.lastname: Di Santo
authors.affiliation: Pathology Department, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Cassoni
authors.affiliation: Histology and Medical Embryology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Nunzia
authors.initials: N
authors.lastname: Bernardini
authors.affiliation: Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia, Italy.
authors.forename: Gabrio
authors.initials: G
authors.lastname: Bassotti
mesh_terms: D004802:Eosinophilia / Q000473:pathology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology*; D012189:Retrospective Studies
keywords: Basal plasmacytosis; diagnosis; eosinophils; immunohistochemistry; inflammatory bowel disease