title: An East-Asian-type cagA Helicobacter pylori Infected Patient with Clinical Manifestation of Gastric Ulcer.
abstract: We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examination revealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopy revealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five different test methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Used polymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-type cagA and vacA s1m1-strain. Further analysis using 7 housekeeping genes confirmed that the strain categorized in to hspEAsia group. The patient was given continuous intravenous infusions of proton pump inhibitor and standard triple therapy regimens eradication of H. pylori.
authors.affiliation: Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia. miphto@yahoo.co.id.
authors.forename: Yudith Annisa Ayu
authors.initials: YA
authors.lastname: Rezkitha
authors.forename: Muhammad
authors.initials: M
authors.lastname: Miftahussurur
authors.forename: Iswan A
authors.initials: IA
authors.lastname: Nusi
authors.forename: Ummi
authors.initials: U
authors.lastname: Maimunah
authors.forename: Pangestu
authors.initials: P
authors.lastname: Adi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D004359:Drug Therapy, Combination; D004384:Duodenoscopy; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D008297:Male; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D054328:Proton Pump Inhibitors; C080866:cagA protein, Helicobacter pylori
keywords: East-Asian-type cagA; Gastric ulcer; Helicobacter pylori; vacA