title: Serum Apo A-1 and Its Role as a Biomarker of Coronary Artery Disease.
abstract: OBJECTIVE
  To evaluate the role of apolipoprotein(Apo A-1) as a biomarker of coronary artery disease (CAD) and its comparison with the traditional marker high-density lipoprotein (HDL).
  
  
  METHODS
  One hundred patients proven to have coronary artery disease by angiography were recruited and their serum biomarkers were compared with 100 normal individuals adjusted for age and sex.
  
  
  RESULTS
  The mean +/-standard deviation (SD) value of plasma Apo A-1 levels in the normal individuals were observed to be 207.42 +/- 41.35 (mg/dL) against 90.69 +/- 20.77 (mg/dL) in the cardiac patients. On the other hand the serum HDL levels were 52.93 +/-33.58 (mg/dL) in the normal individuals and 37.86 +/- 23.19 (mg/dL) in the cardiac patients. Both of these differences were statistically significant (p < 0.001). For Apo A-1, a large proportion of patients (85%) were found to be in the abnormal range when compared to the control group in which only 7% had an abnormal value. For HDL, a majority (70%) of the cardiac patients had abnormal values while 40% of the normal individuals also had abnormal values. The sensitivity of Apo A-1 for detecting CAD was 85%, while for HDL, it was only 69%. Similarly, the specificity of Apo A-1 for detecting CAD was 93%, while for HDL, it was 60%. When plotted on a receiver operating characteristic (ROC) curve, Apo A-1 had a much larger area under the curve when compared to HDL.
  
  
  CONCLUSIONS
  This study suggests that Apo A-1 may, in fact, be more sensitive than HDL as a predictor of CAD. However, to completely elucidate its role as a biomarker, to set target serum levels and to increase its clinical use, further studies are required.
authors.affiliation: Biochemistry, Bacha Khan Medical College.
authors.forename: Salma
authors.initials: S
authors.lastname: Rahim
authors.affiliation: Internal Medicine, Khyber Teaching Hospital.
authors.forename: Hafez Mohammad A
authors.initials: HM
authors.lastname: Abdullah
authors.affiliation: Public Health, Aga Khan University.
authors.forename: Yousaf
authors.initials: Y
authors.lastname: Ali
authors.affiliation: Internal Medicine, Khyber Teaching Hospital.
authors.forename: Uzma I
authors.initials: UI
authors.lastname: Khan
authors.affiliation: Internal Medicine, University of Arizona.
authors.forename: Waqas
authors.initials: W
authors.lastname: Ullah
authors.affiliation: Internal Medicine, Hayatabad Medical Complex.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Shahzad
authors.affiliation: Internal Medicine, Khyber Teaching Hospital.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Waleed
keywords: apo a-1; coronary artery disease; hdl