title: Chromium(II)-catalyzed enantioselective arylation of ketones.
abstract: The chromium-catalyzed enantioselective addition of carbo halides to carbonyl compounds is an important transformation in organic synthesis. However, the corresponding catalytic enantioselective arylation of ketones has not been reported to date. Herein, we report the first Cr-catalyzed enantioselective addition of aryl halides to both arylaliphatic and aliphatic ketones with high enantioselectivity in an intramolecular version, providing facile access to enantiopure tetrahydronaphthalen-1-ols and 2,3-dihydro-1H-inden-1-ols containing a tertiary alcohol.
authors.affiliation: Shenzhen Research Institute of Shandong University, Shenzhen 518057, China; School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Shutao
authors.initials: S
authors.lastname: Sun
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Shenzhen Research Institute of Shandong University, Shenzhen 518057, China; School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
keywords: arylation; asymmetric catalysis; chromium; ketone; tertiary alcohol