title: Sepsis: frontiers in supportive care, organisation and research.
abstract: Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to healthcare systems and society. Despite recent progress, short- and long-term morbidity, mortality and costs remain high in both developed and developing countries. Thus, further improvements in supportive interventions and organisation of care are likely to have a substantial impact upon global health. In this narrative review, invited experts describe the challenges and progress to be made in sepsis research and care in the near future. We focus on supportive care (pulmonary, endocrine, renal, and nutritional support, mediator modulation and precision medicine), organisational themes (guidelines, outcome measures and stakeholder involvement) and clinical research as key areas to improving the care and outcomes of patients with sepsis.
authors.affiliation: Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. anders.perner@regionh.dk.
authors.forename: Anders
authors.initials: A
authors.lastname: Perner
authors.affiliation: St. George's Healthcare NHS Trust, St George's University of London, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Rhodes
authors.affiliation: Department of Intensive Care, Wesley Hospital and Princess Alexandra Hospital, University of Queensland, St Lucia, Australia.|University of Sydney, Sydney, Australia.
authors.forename: Bala
authors.initials: B
authors.lastname: Venkatesh
authors.affiliation: Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Derek C
authors.initials: DC
authors.lastname: Angus
authors.affiliation: Multidisciplinary Intensive Care Research Organization (MICRO), Wellcome Trust-HRB Clinical Research, Dublin, Ireland.|Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's University Hospital, Dublin, Ireland.|CIBER enfermedades respiratorias (CIBERES), Critical Care Center, Madrid, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Martin-Loeches
authors.affiliation: Department of Intensive Care, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Preiser
authors.affiliation: Department of Intensive Care, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Vincent
authors.affiliation: Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Marshall
authors.affiliation: Jena University Hospital, Jena, Germany.
authors.forename: Konrad
authors.initials: K
authors.lastname: Reinhart
authors.affiliation: Division of Intensive Care and Emergency Medicine, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Joannidis
authors.affiliation: Infectious Diseases Division, The Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Opal
mesh_terms: D035843:Biomedical Research / Q000458:organization & administration*; D017281:Cost of Illness; D000071219:Global Burden of Disease; D017408:Guidelines as Topic; D006298:Health Services Administration; D006801:Humans; D015994:Incidence; D010043:Outcome and Process Assessment, Health Care; D057285:Precision Medicine; D018805:Sepsis / Q000401:mortality / Q000628:therapy*
keywords: Acute respiratory failure; Critical care medicine; Intensive care medicine; Renal failure; Sepsis; Shock