title: Overexpression of AQP3 and AQP10 in the skin exacerbates psoriasiform acanthosis.
abstract: We previously observed that aquaporin-3 and aquaporin-10 are upregulated in the epidermis of hand dermatitis patients (Med. Hypotheses, 84, 2015, 498). To address the functional relevance of this upregulation, we overexpressed AQP3/AQP10 in mice using the human K1 promoter. Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10. Aquaporin overexpression also drove a trend towards greater weight loss in these animals. These data support a role for cutaneous aquaporins in the pathogenesis of dermatitis and as a potential target in their treatment.
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.|Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Soler
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Young
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Alexis D
authors.initials: AD
authors.lastname: Griffith
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Ping Fu
authors.initials: PF
authors.lastname: Fu
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.|Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA.|VA Medical Center, Cleveland, OH, USA.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Cooper
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.|Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: McCormick
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.|VA Medical Center, Cleveland, OH, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Popkin
mesh_terms: D000634:Aminoquinolines; D000818:Animals; D051400:Aquaporin 3 / Q000235:genetics* / Q000378:metabolism; D020346:Aquaporins / Q000235:genetics* / Q000378:metabolism; D002454:Cell Differentiation; D003872:Dermatitis / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D003902:Detergents; D004817:Epidermis / Q000378:metabolism*; D000091344:Filaggrin Proteins; D000077271:Imiquimod; D007381:Intermediate Filament Proteins / Q000235:genetics / Q000378:metabolism; D053550:Keratin-10 / Q000235:genetics / Q000378:metabolism; D015603:Keratinocytes / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D015854:Up-Regulation; D015431:Weight Loss
chemical_list: D000634:Aminoquinolines; C496028:Aqp3 protein, mouse; D020346:Aquaporins; D003902:Detergents; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D008565:Membrane Proteins; C064554:loricrin; D053550:Keratin-10; D051400:Aquaporin 3; D000077271:Imiquimod
keywords: aquaporin-10; aquaporin-3; dermatitis; filaggrin; imiquimod