title: Diagnostic accuracy of lipopolysaccharide-binding protein for sepsis in patients with suspected infection in the emergency department.
abstract: Background Biomarkers can facilitate the diagnosis of sepsis, enabling early management and improving outcomes. Lipopolysaccharide-binding protein (LBP) has been reported as a biomarker for the detection of infection, but its diagnostic value is controversial. In this study, we assessed the diagnostic accuracy of LBP for sepsis in the emergency department (ED) patients, comparing it with more established biomarkers of sepsis, including procalcitonin (PCT) and C-reactive protein (CRP). Methods LBP and other sepsis biomarkers, including PCT and CRP, were measured on admission in 102 adult patients presenting with suspected infection . Classification of patients was performed using the recently updated definition for sepsis (Sepsis-3). The diagnostic accuracy of LBP, CRP and PCT for sepsis was evaluated by using receiver operating characteristic curve (ROC) analysis. Results A total of 49 patients were classified as having sepsis. In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers). ROC curve analysis and area under curve (AUC) revealed a value of 0.701 for LBP, similar to CRP (0.707) and lower than that for PCT (0.844) ( P = 0.012). Conclusion In adult ED patients with suspected infection, the diagnostic accuracy for sepsis of LBP is similar to that of CRP but lower than that of PCT.
authors.affiliation: 1 Clinical Chemistry Laboratory, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: García de Guadiana Romualdo
authors.affiliation: 1 Clinical Chemistry Laboratory, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Albaladejo Otón
authors.affiliation: 2 Intensive Care Unit, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rebollo Acebes
authors.affiliation: 1 Clinical Chemistry Laboratory, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Esteban Torrella
authors.affiliation: 1 Clinical Chemistry Laboratory, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Hernando Holgado
authors.affiliation: 1 Clinical Chemistry Laboratory, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Jiménez Santos
authors.affiliation: 2 Intensive Care Unit, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Jiménez Sánchez
authors.affiliation: 2 Intensive Care Unit, Santa Lucía Hospital, Cartagena, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ortón Freire
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000378:metabolism*; D004636:Emergency Service, Hospital / Q000458:organization & administration*; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D018805:Sepsis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D055815:Young Adult; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein
keywords: Analytes; proteins