title: [Unresectable Stage IV Sigmoid Colon Cancer with Extended Resection for Primary Tumor - A Case Report].
abstract: A 65-year-old woman who was diagnosed with unresectable Stage IV sigmoid colon cancer underwent transverse colostomy with double orifices. Although KRAS gene mutation was observed, we could not administer bevacizumab because of the risk of bleeding from the primary tumor and peritumoral abscess. We started bi-weekly XELOX therapy but bloody bowel discharge continued. We planned extended resection of the primary tumor in order to control the bleeding and perforation. Sigmoidectomy, partial resection of the left ureter and small intestine, partial hysterectomy, bilateral salpingo-oophorectomy, and umbilical tumor resection were performed and the patient was discharged on the 10th day after surgery. After surgery, bloody bowel discharge disappeared and bevacizumab was administered in the 55th day. Extended resection for a primary tumor may contribute to bleeding control and broaden treatment options.
authors.affiliation: Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kimura
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tomochika
authors.forename: Yuka
authors.initials: Y
authors.lastname: Inoue
authors.forename: Hironori
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tokuhisa
authors.forename: Michihisa
authors.initials: M
authors.lastname: Iida
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takeda
authors.forename: Tomio
authors.initials: T
authors.lastname: Ueno
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Yoshino
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hazama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
mesh_terms: D000368:Aged; D003082:Colectomy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010052:Ovariectomy; D012811:Sigmoid Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D016896:Treatment Outcome