title: Talkin' about my (re)generation: The who of intrinsic retinal stem cells.
abstract: World-wide, two degenerative retinal diseases, glaucoma and age-related macular degeneration, are estimated to affect more than 12% of individuals over the age of 40 (Tham et al., 2014; Wong et al., 2014). Current therapies can slow progression, but cannot restore lost neurons or vision. Thus, there is increasing interest in developing strategies for therapeutic retinal regeneration. Nearly 50years of research on retinal neurogenesis and regeneration has identified Müller glia as intrinsic retinal stem cells in teleost fish. In the mammalian retina, there is no de novo neurogenesis in adults and only very limited injury-induced regeneration has been induced using exogenous growth factors. The study by (Webster et al., 2017) (Evidence of BrdU Positive Retinal Neurons after Application of an Alpha7 Nicotinic Acetylcholine Receptor Agonist, this issue) is the first to show robust, retinal neurogenesis in an adult, mammalian retina in the absence of overt injury and provides evidence that the source of the new neurons is likely to be the Müller glia. This exciting finding has the potential to be a game-changer in the field of retinal regeneration.
authors.affiliation: University of Houston, College of Optometry, Houston, TX 77204, United States. Electronic address: dotteson@central.uh.edu.
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Otteson
mesh_terms: D000818:Animals; D006801:Humans; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis; D012038:Regeneration; D012162:Retinal Degeneration / Q000503:physiopathology*; D055351:Retinal Neurons / Q000502:physiology*
keywords: Müller glia, mammal, teleost; alpha7 nicotinic acetylcholine; neurogenesis; receptor (a7-nAChR); retina