title: The impact of fetal middle cerebral artery Doppler on the outcome of congenital hydrocephalus.
abstract: OBJECTIVE
  The objective of this study is to investigate the impact of abnormal middle cerebral artery (MCA) Doppler on the perinatal mortality in fetuses with congenital hydrocephalus (CH).
  
  
  METHODS
  A prospective study of all fetuses with CH who delivered at our hospital over a period of 7 years. Data were obtained from the ultrasound, Labor room and intensive neonatal care unit (NICU) database. The Perinatal mortality rates were evaluated in relation to the following measures, associated congenital anomalies, cortical mantle thickness (CMT), and MCA Doppler abnormalities (absent or reversed diastole). The main outcome measure was perinatal mortality rate in relation to MCA Doppler changes.
  
  
  RESULTS
  A total of 85 cases of CH were diagnosed and managed. The birth prevalence of CH was 2.44 per 1000 live births. On one hand, the perinatal mortality rate was higher in those fetuses with non-isolated hydrocephalus, (37.25% (19/51) versus (35.29% (12/34, p = 0.854 and in those cases with CMT <10 mm, 38.78% (19/49) versus 33.33% (12/36) in those with CMT >10 mm, p = 0.607. On the other hand, the perinatal mortality rate was significantly higher in those fetuses with abnormal MCA Doppler, (100% (13/13) versus 25% (18/72), OR = 78.0, 95% CI (5.52-44085124.60), p < 0.001.
  
  
  CONCLUSIONS
  Abnormal fetal MCA Doppler (absent or reversed diastole) appears to be a poor prognostic indicator with significantly high perinatal mortality in fetuses with CH.
authors.affiliation: a Department of Obstetrics and Gynecology , King Abdullah University Hospital, Jordan University of Science and Technology , Irbid , Jordan.|b Department of Fetal Medicine and Ultrasound , Women's' Specialized Hospital, King Fahad Medical City , Riyadh , Saudi Arabia.
authors.forename: Nail
authors.initials: N
authors.lastname: Obeidat
authors.affiliation: b Department of Fetal Medicine and Ultrasound , Women's' Specialized Hospital, King Fahad Medical City , Riyadh , Saudi Arabia.
authors.forename: Bahauddin
authors.initials: B
authors.lastname: Sallout
authors.affiliation: b Department of Fetal Medicine and Ultrasound , Women's' Specialized Hospital, King Fahad Medical City , Riyadh , Saudi Arabia.
authors.forename: Badi
authors.initials: B
authors.lastname: Albaqawi
authors.affiliation: b Department of Fetal Medicine and Ultrasound , Women's' Specialized Hospital, King Fahad Medical City , Riyadh , Saudi Arabia.
authors.forename: Wajeih
authors.initials: W
authors.lastname: Al AlAali
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005313:Fetal Death; D005315:Fetal Diseases / Q000401:mortality*; D006801:Humans; D006849:Hydrocephalus / Q000151:congenital / Q000401:mortality*; D007231:Infant, Newborn; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D016135:Spinal Dysraphism / Q000150:complications / Q000453:epidemiology; D050497:Stillbirth; D018608:Ultrasonography, Doppler / Q000379:methods*; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult
keywords: Congenital hydrocephalus; middle cerebral artery; perinatal mortality; reversed diastolic flow