title: T cell responses in the central nervous system.
abstract: T cells are required for immune surveillance of the central nervous system (CNS); however, they can also induce severe immunopathology in the context of both viral infections and autoimmunity. The mechanisms that are involved in the priming and recruitment of T cells to the CNS are only partially understood, but there has been renewed interest in this topic since the 'rediscovery' of lymphatic drainage from the CNS. Moreover, tissue-resident memory T cells have been detected in the CNS and are increasingly recognized as an autonomous line of host defence. In this Review, we highlight the main mechanisms that are involved in the priming and CNS recruitment of CD4+T cells, CD8+T cells and regulatory T cells. We also consider the plasticity of T cell responses in the CNS, with a focus on viral infection and autoimmunity.
authors.affiliation: Klinikum Rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany.|Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Korn
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.|Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Axel
authors.initials: A
authors.lastname: Kallies
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology