title: Mycotoxins from the Fungus Botryotrichum piluliferum.
abstract: Two new sterigmatocystin derivatives, oxisterigmatocystins E and F (1 and 2, respectively), along with nine known compounds, oxisterigmatocystins G and H (3 and 4, respectively), sterigmatocystin (5), N-0532B (6), O-methylsterigmatocystin (7), N-0532A (8), 6-O-methylversicolorin A (9), 6,8-O-dimethylversicolorin A (10), and 8-O-methylaverufin (11), were isolated from the fungus Botryotrichum piluliferum. The structures of these mycotoxins were elucidated by spectroscopic evidence. Among these, compounds 3, 4, and 9 were discovered as natural products for the first time. Compounds 1, 3, and 4 displayed antimalarial activity toward Plasmodium falciparum (IC50= 7.9-23.9 μM). In addition, compounds 1-6 and 8-11 exhibited cytotoxicity against KB, MCF-7, and NCI-H187 cell lines (IC50= 0.38-78.6 μM). However, compounds 1-9 showed cytotoxic effects against the Vero cell line (IC50= 0.65-12.3 μM). This finding should promote awareness of the contamination of B. piluliferum in the food chain and agricultural soil.
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University , Khon Kaen 40002, Thailand.
authors.forename: Oue-Artorn
authors.initials: OA
authors.lastname: Rajachan
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University , Khon Kaen 40002, Thailand.
authors.forename: Kwanjai
authors.identifier: http://orcid.org/0000-0002-3237-2920
authors.initials: K
authors.lastname: Kanokmedhakul
authors.affiliation: Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang , Bangkok 10520, Thailand.
authors.forename: Kasem
authors.initials: K
authors.lastname: Soytong
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University , Khon Kaen 40002, Thailand.
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D020037:Sordariales / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000962:Antimalarials; D009183:Mycotoxins
keywords: Botryotrichum piluliferum; Chaetomiaceae; cytotoxicity; mycotoxin; sterigmatocystin