title: Gut Microbiota in Obesity and Undernutrition.
abstract: Malnutrition is the result of an inadequate balance between energy intake and energy expenditure that ultimately leads to either obesity or undernutrition. Several factors are associated with the onset and preservation of malnutrition. One of these factors is the gut microbiota, which has been recognized as an important pathophysiologic factor in the development and sustainment of malnutrition. However, to our knowledge, the extent to which the microbiota influences malnutrition has yet to be elucidated. In this review, we summarize the mechanisms via which the gut microbiota may influence energy homeostasis in relation to malnutrition. In addition, we discuss potential therapeutic modalities to ameliorate obesity or undernutrition.
authors.affiliation: Department of Internal and Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands; n.c.declercq@amc.uva.nl.
authors.forename: Nicolien C
authors.identifier: 0000-0002-9924-7171
authors.initials: NC
authors.lastname: de Clercq
authors.affiliation: Department of Internal and Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands.|Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
authors.forename: Albert K
authors.initials: AK
authors.lastname: Groen
authors.affiliation: Department of Internal and Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands.
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Romijn
authors.affiliation: Department of Internal and Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands.|Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, Netherlands; and.|Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Max
authors.initials: M
authors.lastname: Nieuwdorp
mesh_terms: D000818:Animals; D001066:Appetite; D002149:Energy Intake; D004734:Energy Metabolism; D005232:Fatty Acids, Volatile / Q000378:metabolism; D000069467:Fecal Microbiota Transplantation; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D044342:Malnutrition / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology / Q000628:therapy; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology / Q000628:therapy; D056692:Prebiotics; D019936:Probiotics
chemical_list: D005232:Fatty Acids, Volatile; D056692:Prebiotics
keywords: appetite; energy homeostasis; fecal transplantation; gut microbiota; gut-brain axis; malnutrition; obesity; prebiotics; probiotics; undernutrition