title: The Impact of Antibiotic Consumption on Development ofAcinetobacter Baumannii Resistance.
abstract: OBJECTIVE
  The aim of this study was to examine the impact of antibiotic consumption on development of antimicrobial resistance in Acinetobacter baumannii.
  
  
  METHODS
  The study was conducted in University Clinical Center of Sarajevo. In our retrospective study Acinetobacter baumannii isolated in period from July 1st2009 to December 31st2012. Isolates were detected from different clinical samples including urine, wound swab, blood, bronchial aspirate and other samples which were collected from patients situated on various hospital wards. Clinical isolates belonged to one per patient in a given period of time.
  
  
  RESULTS
  Antimicrobial resistance was interpreted according to CLSI breakpoints. Consumption of antibiotics was analyzed according to recommendations of the ESAC-Net and current Acinetobacter baumannii classification. Pearson's correlation showed a positive correlation between gentamicin consumption and emerging of resistance (p = 0.023).
  
  
  CONCLUSIONS
  Increase in the antimicrobial use was followed with an increase in resistance of Acinetobacter baumannii isolates. Monitoring of antibiotic resistance and consumption is of a great importance in order to reduce the emergence and spread of antimicrobial resistant organisms in the health care settings.
authors.affiliation: Clinical Microbiology, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors.forename: Djana
authors.initials: D
authors.lastname: Granov
authors.affiliation: Clinical Microbiology, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors.forename: Amela Dedeic
authors.initials: AD
authors.lastname: Ljubovic
authors.affiliation: Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine University of Sarajevo, Bosnia and Herzegovina.
authors.forename: Svjetlana Loga
authors.initials: SL
authors.lastname: Zec
authors.affiliation: Clinic for Cardio Surgery, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors.forename: Nermir
authors.initials: N
authors.lastname: Granov
authors.affiliation: Institute for Biomedical Diagnostics and Research-Nalaz, Sarajevo, Bosnia and Herzegovina and International Burch University, Sarajevo, Bosnia and Herzegovina.
authors.forename: Mirsada
authors.initials: M
authors.lastname: Hukic
keywords: antimicrobials; consumption; surveillance