title: Early Diagnosis ofHelicobacter pyloriInfection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study.
abstract: Aims. To investigateH. pyloriinfection rate and evaluate a combined set of tests forH. pyloridiagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD).Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out randomly. Patients without RUT or with negative RUT received urea breath test (UBT) and serological and urinaryH. pyloriantibody tests.H. pyloriwas considered positive if RUT or any noninvasive test was positive. Patients were divided into group A (RUT plus noninvasive tests) and group B (only noninvasive tests).Results. The overallH. pyloriinfection rate was 94.2% (161/171). Groups A and B had no differences in demographic characteristics, bleeding severity, endoscopic findings, and proton pump inhibitor use.H. pylori-positive rate in group A was significantly higher than that in group B (98.2% versus 86.7%,p= 0.004). The positive rate of RUT was similar at each biopsy site but significantly increased if RUT results from 2 or 3 sites were combined (p< 0.05).Conclusions.H. pyloriinfection rate in Vietnamese patients with acute PUB is high. RUT is an excellent test if at least 2 biopsies are taken.
authors.affiliation: Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh, Vietnam; Department of Gastroenterology, Gia Dinh People's Hospital, Ho Chi Minh City, Vietnam.
authors.forename: Duc Trong
authors.initials: DT
authors.lastname: Quach
authors.affiliation: Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh, Vietnam; Department of Gastroenterology, Gia Dinh People's Hospital, Ho Chi Minh City, Vietnam.
authors.forename: Mai Ngoc
authors.initials: MN
authors.lastname: Luu
authors.affiliation: Health Service Center, Hiroshima University, Higashihiroshima, Japan.
authors.forename: Toru
authors.identifier: 0000-0002-5843-232X
authors.initials: T
authors.lastname: Hiyama
authors.affiliation: Department of Endoscopy, Gia Dinh People's Hospital, Ho Chi Minh City, Vietnam.
authors.forename: Thuy-HuongThi
authors.initials: TH
authors.lastname: To
authors.affiliation: Department of Endoscopy, Gia Dinh People's Hospital, Ho Chi Minh City, Vietnam.
authors.forename: Quy Nhuan
authors.initials: QN
authors.lastname: Bui
authors.affiliation: Department of Endoscopy, Gia Dinh People's Hospital, Ho Chi Minh City, Vietnam.
authors.forename: Tuan Anh
authors.initials: TA
authors.lastname: Tran
authors.affiliation: Department of Endoscopy, Gia Dinh People's Hospital, Ho Chi Minh City, Vietnam.
authors.forename: Binh Duy
authors.initials: BD
authors.lastname: Tran
authors.affiliation: Department of Gastroenterology, Gia Dinh People's Hospital, Ho Chi Minh City, Vietnam.
authors.forename: Minh-Cong Hong
authors.initials: MH
authors.lastname: Vo
authors.affiliation: Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Ichikawa, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Uemura