title: Pimping up Drugs Recovered, Superannuated and Under Exploited Drugs - An Introduction to the Basics of Drug Reprofiling.
abstract: Drug development has moved along way forward from the days of with doctors peddling cauldrons of herbs and spices, however, the process can still miss opportunities for full exploitation of a drug's potential. Drug reprofiling provides a chance for an established or a forgotten drug to move into a new area of therapy, whether related to the known effects or in a completely new area. In an era of environmental awareness and spiraling costs for traditional drug development, a strategy to squeeze every benefit out of drugs with known safety, tolerability and pharmacological parameters must be a strategically sound desire. We explore examples of success in reprofiling, draw comparisons between techniques, and finally provide two examples from the Valirx plc development pipeline currently undergoing the process.
authors.affiliation: ValiSeek Limited, London, United Kingdom.
authors.forename: Suzanne J
authors.initials: SJ
authors.lastname: Dilly
authors.affiliation: ValiRx plc, London, United Kingdom.
authors.forename: George S
authors.initials: GS
authors.lastname: Morris
mesh_terms: D058492:Drug Repositioning; D018973:Intellectual Property; D056687:Off-Label Use
keywords: Reprofiling; cancer; development; health economics; risperidone; techniques