title: Role of Rab GTPases in the export trafficking of G protein-coupled receptors.
abstract: G protein-coupled receptors (GPCRs) constitute a superfamily of cell surface receptors that regulate a variety of cell functions. As the cell surface is the functional destination for most GPCRs, the cell surface targeting process represents a crucial checkpoint in controlling the functionality of the receptors. However, the molecular mechanisms underlying the cell surface delivery of newly synthesized GPCRs remain poorly understood. In this review, we will highlight the role of Rab GTPases in GPCR cell surface transport, particularly post-Golgi traffic, and discuss the underlying molecular mechanisms.
authors.affiliation: a Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China.
authors.forename: Guansong
authors.initials: G
authors.lastname: Wang
authors.affiliation: b Department of Pharmacology and Toxicology , Medical College of Georgia, Augusta University , Augusta , GA , USA.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wei
authors.affiliation: b Department of Pharmacology and Toxicology , Medical College of Georgia, Augusta University , Augusta , GA , USA.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Wu
mesh_terms: D000818:Animals; D006801:Humans; D021381:Protein Transport; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D013379:Substrate Specificity; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled; D020691:rab GTP-Binding Proteins
keywords: G protein-coupled receptor; Rab GTPase; Rab26; Rab8; cell surface expression; export trafficking; post-Golgi traffic