title: ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology.
abstract: The lymphatic system plays an important role in the induction of the immune response by transporting antigens, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes. It is emerging that lymphatic endothelial cells (LECs) are playing an active role in this contextviathe expression of chemokines, inflammatory mediators promoting cell migration, and chemokine receptors. Particularly, LECs express atypical chemokine receptors (ACKRs), which are unable to promote conventional signaling and cell migration while they are involved in the regulation of chemokine availability. Here, we provide a summary of the data on the role of ACKR2 expressed by lymphatics, indicating an essential role for this ACKRs in the regulation of the inflammation and the immune response in different pathological conditions, including infection, allergy, and cancer.
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
authors.forename: Ornella
authors.initials: O
authors.lastname: Bonavita
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Mollica Poeta
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Setten
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Massara
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
keywords: atypical chemokine receptor; chemokine; chemokine receptor; inflammation; lymphatic vessels