title: Imidazolium-based titanium substrates against bacterial colonization.
abstract: Nosocomial infections are often induced by the presence of pathogenic organisms on the surface of medical devices or hospital equipment. Chemical modifications of the surface are recognized as efficient strategies to prevent bacterial adhesion but they may have a negative impact on the material's interaction with living tissues. Here we have developed a photoactivated method for the modification of titanium substrates. A photoinduced technique employing a grafting-onto process has been successfully performed to covalently anchor an imidazolium-derivative siloxane onto titanium surfaces. Imidazolium surfaces showed higher bacteria-repellency performances than native titanium substrates, achieving more than 98% anti-adhesion efficiency against Escherichia coli after 24 h of incubation. In addition, these surfaces allowed for the adhesion and viability of osteoblasts cells without evidence of cytotoxicity.
authors.affiliation: Institut de Chimie et des Matériaux Paris-Est, UMR 7182, CNRS-Université Paris-Est Créteil (UPEC), 2-8 rue Henri Dunant, 94320 Thiais, France. versace@icmpe.cnrs.fr.
authors.forename: T
authors.initials: T
authors.lastname: Cavoue
authors.affiliation: Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS, FRE3517, Université de Picardie Jules Verne, 33 rue saint leu, Amiens, FR 80039, France.
authors.forename: H
authors.initials: H
authors.lastname: Bounou Abassi
authors.affiliation: Université de Technologie de Compiègne, Centre de Recherche, UMR 6600, rue Personne de Roberval, BP 20 529, Compiegne, FR 60200, France.
authors.forename: M
authors.initials: M
authors.lastname: Vayssade
authors.affiliation: Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS, FRE3517, Université de Picardie Jules Verne, 33 rue saint leu, Amiens, FR 80039, France.
authors.forename: A
authors.initials: A
authors.lastname: Nguyen Van Nhien
authors.affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, South Korea.
authors.forename: I-K
authors.identifier: http://orcid.org/0000-0002-6781-6026
authors.initials: IK
authors.lastname: Kang
authors.affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, South Korea.
authors.forename: G-W
authors.initials: GW
authors.lastname: Kwon
authors.affiliation: Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS, FRE3517, Université de Picardie Jules Verne, 33 rue saint leu, Amiens, FR 80039, France.
authors.forename: G
authors.initials: G
authors.lastname: Pourceau
authors.affiliation: Institut de Chimie et des Matériaux Paris-Est, UMR 7182, CNRS-Université Paris-Est Créteil (UPEC), 2-8 rue Henri Dunant, 94320 Thiais, France. versace@icmpe.cnrs.fr.
authors.forename: P
authors.identifier: http://orcid.org/0000-0003-4339-9683
authors.initials: P
authors.lastname: Dubot
authors.affiliation: Unité Bioemco Equipe IBIOS, UMR 7618 CNRS - Université Paris-Est Créteil Val-de-Marne, 61, Avenue Général de Gaulle, 94010 Créteil Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Abbad Andaloussi
authors.affiliation: Institut de Chimie et des Matériaux Paris-Est, UMR 7182, CNRS-Université Paris-Est Créteil (UPEC), 2-8 rue Henri Dunant, 94320 Thiais, France. versace@icmpe.cnrs.fr.
authors.forename: D-L
authors.identifier: http://orcid.org/0000-0002-4272-5021
authors.initials: DL
authors.lastname: Versace
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001422:Bacterial Adhesion; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004926:Escherichia coli / Q000166:cytology*; D004927:Escherichia coli Infections / Q000517:prevention & control; D006801:Humans; D006868:Hydrolysis; D007093:Imidazoles / Q000737:chemistry*; D051379:Mice; D055668:Photochemical Processes; D012833:Siloxanes / Q000737:chemistry*; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000166:cytology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D007093:Imidazoles; D012833:Siloxanes; D014025:Titanium