title: The -938C>A Polymorphism inMYD88Is Associated with Susceptibility to Tuberculosis: A Pilot Study.
abstract: Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB.Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB.Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for theMYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms.Results. TheMYD88-938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89-11.28,p= 0.01).Conclusions. TheMYD88-938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.
authors.affiliation: Department of Respiratory Medicine, University of Thessaly Medical School, Larissa, Greece; 9th Department for Chest Diseases, "Sotiria" Hospital, Athens, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Aggelou
authors.affiliation: 9th Department for Chest Diseases, "Sotiria" Hospital, Athens, Greece.
authors.forename: Elena Konstantina
authors.initials: EK
authors.lastname: Siapati
authors.affiliation: Department of Respiratory Medicine, University of Thessaly Medical School, Larissa, Greece.
authors.forename: Irini
authors.initials: I
authors.lastname: Gerogianni
authors.affiliation: Department of Respiratory Medicine, University of Thessaly Medical School, Larissa, Greece.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Daniil
authors.affiliation: Department of Respiratory Medicine, University of Thessaly Medical School, Larissa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gourgoulianis
authors.affiliation: 9th Department for Chest Diseases, "Sotiria" Hospital, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Ntanos
authors.affiliation: Cell and Gene Therapy Laboratory, Center for Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
authors.forename: Emmanouel
authors.initials: E
authors.lastname: Simantirakis
authors.affiliation: Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece.
authors.forename: Elias
authors.initials: E
authors.lastname: Zintzaras
authors.affiliation: Hellenic National Bioethics Committee, Athens, Greece; Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological Educational Institution of Athens, Athens, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Mollaki
authors.affiliation: Cell and Gene Therapy Laboratory, Center for Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; Division of Haematology, University of Thessaly Medical School, Larissa, Greece.
authors.forename: George
authors.identifier: 0000-0003-4744-7486
authors.initials: G
authors.lastname: Vassilopoulos
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D058889:Molecular Typing; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification / Q000502:physiology; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics*; D016017:Odds Ratio; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000235:genetics* / Q000382:microbiology
chemical_list: C507779:MYD88 protein, human; D053594:Myeloid Differentiation Factor 88