title: Ocular Surface Epithelial Atypia Mimicking Squamous Neoplasia in Association With Ulcerative Colitis.
abstract: OBJECTIVE
  Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC).
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids.
  
  
  CONCLUSIONS
  Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.
authors.affiliation: Departments of *Ophthalmology; †Pathology; and ‡Radiation Oncology, Duke University Medical Center, Durham, NC; and §Department of Ophthalmology, Stanford University Medical Center, Palo Alto, CA.
authors.forename: Sally S
authors.initials: SS
authors.lastname: Ong
authors.forename: Scott D
authors.initials: SD
authors.lastname: Walter
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Gargi K
authors.initials: GK
authors.lastname: Vora
authors.forename: Melissa
authors.initials: M
authors.lastname: Daluvoy
authors.forename: Alan D
authors.initials: AD
authors.lastname: Proia
authors.forename: Prithvi
authors.initials: P
authors.lastname: Mruthyunjaya
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy; D003228:Conjunctiva / Q000473:pathology*; D003315:Cornea / Q000473:pathology*; D003937:Diagnosis, Differential; D004338:Drug Combinations; D004847:Epithelial Cells / Q000473:pathology*; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D019804:Mesalamine / Q000627:therapeutic use; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D018307:Neoplasms, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D005938:Glucocorticoids; D019804:Mesalamine; D008776:Methylprednisolone Hemisuccinate; D011241:Prednisone