title: Lack of Altered BECN1 Gene Expression in Iranian Patients with Acute Myeloid Leukemia
abstract: Acute myeloid leukemia (AML), one of the most prevalent leukemia types in adults, demonstrates great heterogeneity
  in molecular and clinical terms. Hence, there is a necessity to the mechanisms involved in AML generation in order to
  determine optimal treatment. This cross sectional study aimed to assess changes in BECN1 gene expression in with
  blood samples from 30 AML patients, compared with samples from 15 healthy persons. RNA was extracted and cDNA
  was synthesized and Real Time PCR applied to determine BECN1 gene expression. The results showed no significant
  differences in BECN1 gene expression between patients with AML and normal controls (P > 0.05). It appears that
  expression of BECN1 does not play a significant role in genesis of AML leukemia.
authors.affiliation: Department of Genetic, South PNU Centre, payame noor university, Tehran, Iran. Email: movafagh_a@yahoo.com
authors.forename: Ladan
authors.initials: L
authors.lastname: Keyvan
authors.forename: Seyed Kazem
authors.initials: SK
authors.lastname: Bidoki
authors.forename: Davood
authors.initials: D
authors.lastname: Zare Abdollahi
authors.forename: Neda
authors.initials: N
authors.lastname: Mansouri
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Sa
authors.initials: S
authors.lastname: Mortazavi Tabatabaei
authors.forename: Hediyeh
authors.initials: H
authors.lastname: Fardmanesh
authors.forename: Mansour
authors.initials: M
authors.lastname: Meimandi
authors.forename: Seyed Majid
authors.initials: SM
authors.lastname: Ayatollahi
authors.forename: Hasan
authors.initials: H
authors.lastname: Jalaeikhoo
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Movafagh
keywords: Leukemia; BECN1; changes in gene expression