title: [Two Cases of Krukenberg Tumors That Metastasized from Gastric Cancer Treated with Multidisciplinary Therapy].
abstract: A 34-year-old woman underwent total gastrectomy with D2 lymphadenectomy for gastric cancer, and the final diagnosis was T4N3M0, Stage III C, R0. Bilateral ovarian metastases were identified 51 months later, which were removed, and the patient received S-1 plus CDDP chemotherapy. Because the patient developed pubic bone metastasis 16 months after the second operation, we continued chemotherapy using paclitaxel with bisphosphonate. The patient was alive 70 months after the initial operation. The second patient was a 55-year-old woman who underwent total gastrectomy with D2 lymphadenectomy and was diagnosed with T2N2M0, Stage III A gastric cancer. Bilateral ovarian metastases were identified 72 months later, which were removed, and the patient received S-1 plus CDDP chemotherapy. The patient is alive with no signs of disease recurrence 96 months after the initial operation. For patients with ovarian metastases from gastric cancer, surgical resection in addition to chemotherapy might be an effective treatment. However, further studies and assessments of additional cases are needed to confirm the ideal treatment for this condition.
authors.affiliation: Dept. of Surgery, Kochi Medical School.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Namikawa
authors.forename: Kazune
authors.initials: K
authors.lastname: Fujisawa
authors.forename: Eri
authors.initials: E
authors.lastname: Munekage
authors.forename: Masaya
authors.initials: M
authors.lastname: Munekage
authors.forename: Mai
authors.initials: M
authors.lastname: Shiga
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Maeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nagata
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Kumon
authors.forename: Michiya
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hanazaki
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007725:Krukenberg Tumor / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D010052:Ovariectomy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery