title: Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure　- New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients.
abstract: The mechanisms of heart failure with preserved ejection fraction (HFpEF) need to be clarified immediately.
  
  
  
  We examined diastolic function relative to arterial elasticity among hypertensive patients with preserved EF. Diastolic elastance (EdI)/effective arterial elastance (EaI), EdI/EaI=E/e'/(0.9×systolic blood pressure [SBP]) was significantly more impaired in women than in men among patients ≥75 years. The higher EdI/EaI value in elderly women implies they are intermittently exposed to higher left ventricular filling pressure relative to SBP during daily life.
  
  
  
  Highly fluctuating impairment of diastolic function relative to arterial elasticity may predispose elderly women to pulmonary edema.
authors.affiliation: Department of Cardiovascular Medicine, Yao Municipal Hospital.
authors.forename: Shiro
authors.initials: S
authors.lastname: Hoshida
authors.affiliation: Department of Cardiovascular Medicine, Yao Municipal Hospital.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Shinoda
authors.affiliation: Department of Cardiovascular Medicine, Yao Municipal Hospital.
authors.forename: Kuniyasu
authors.initials: K
authors.lastname: Ikeoka
authors.affiliation: Department of Cardiovascular Medicine, Yao Municipal Hospital.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Minamisaka
authors.affiliation: Department of Cardiovascular Medicine, Yao Municipal Hospital.
authors.forename: Hidetada
authors.initials: H
authors.lastname: Fukuoka
authors.affiliation: Department of Cardiovascular Medicine, Yao Municipal Hospital.
authors.forename: Hirooki
authors.initials: H
authors.lastname: Inui
authors.affiliation: Department of Cardiovascular Medicine, Yao Municipal Hospital.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000502:physiology; D003971:Diastole / Q000502:physiology*; D004548:Elasticity / Q000502:physiology; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000209:etiology; D012737:Sex Factors; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Aging; Arterial elasticity; Diastolic function; Women