title: Overview of the current knowledge on etiology, natural history and treatment of aortic dissection.
abstract: In this manuscript, we review the etiology, classification, clinical manifestation, behavior, management and outcomes of aortic dissection. We emphasize the importance of genetics in the development of aortic dissection, discuss the role of size in clinical decision-making, and review the mechanism of aortic dissection development as well as the maturation of the dissected aorta.
authors.affiliation: Aortic Institute, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Swapnil
authors.initials: S
authors.lastname: Parve
authors.affiliation: Aortic Institute, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.|Department of Surgical Diseases no. 2, Kazan State Medical University, Kazan, Russia.
authors.forename: Bulat A
authors.initials: BA
authors.lastname: Ziganshin
authors.affiliation: Aortic Institute, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA - john.elefteriades@yale.edu.
authors.forename: John A
authors.initials: JA
authors.lastname: Elefteriades
mesh_terms: D000784:Aortic Dissection / Q000000981:diagnostic imaging / Q000235:genetics / Q000401:mortality / Q000601:surgery*; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging / Q000235:genetics / Q000401:mortality / Q000601:surgery*; D001027:Aortography / Q000379:methods; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D000072226:Computed Tomography Angiography; D057510:Endovascular Procedures / Q000009:adverse effects; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D005819:Genetic Markers