title: Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified.
abstract: OBJECTIVE
  T-cell prolymphocytic leukemia (T-PLL) is a very rare, aggressive T-cell neoplasm. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore, we aimed to determine the clinical and pathological differences between T-PLL and PTCL-NOS.
  
  
  METHODS
  We analyzed 15 T-PLL and 91 PTCL-NOS patients and also compared clinical features between T-PLL and PTCL-NOS with leukemic presentation. Peripheral blood images and biopsy specimens were analyzed, and treatment responses were determined via imaging modalities. The clinicopathological characteristics were statistically compared.
  
  
  RESULTS
  T-PLL cells were smaller in size than those of PTCL-NOS with leukemic presentation (P=.0068); moreover, PTCL-NOS cells with leukemic presentation were smaller than those of PTCL-NOS without leukemic presentation (P=.0017). Immunophenotypic patterns in T-PLL and PTCL-NOS were similar. Five-year overall survival rates of T-PLL and all PTCL-NOS patients were 57.5% and 36.8%, respectively. No significant differences were found in clinical manifestations or prognoses; T-PLL and PTCL-NOS with leukemic presentation had essentially equivalent characteristics.
  
  
  CONCLUSIONS
  T-PLL and PTCL-NOS may share common biological and clinical characteristics in Japanese patients.
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.|Department of Hematology, Endocrinology, and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
authors.forename: Keisuke
authors.identifier: http://orcid.org/0000-0002-9040-285X
authors.initials: K
authors.lastname: Kawamoto
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyoshi
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Yanagida
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yoshida
authors.affiliation: Department of Hematology, Iizuka Hospital, Iizuka, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kiyasu
authors.affiliation: Department of Hematology, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan.
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Kozai
authors.affiliation: Division of Medical Oncology, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors.forename: Tatsuma
authors.initials: T
authors.lastname: Morikita
authors.affiliation: Department of Hematology, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Hematology, Kumamoto Shinto General Hospital, Kumamoto, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzushima
authors.affiliation: Department of Hematology and Oncology, Wakayama Medical University, Wakayama, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tamura
authors.affiliation: Department of Hematology, Japan Community Health Care Organization Kyushu Hospital, Kitakyushu, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Muta
authors.affiliation: Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.affiliation: Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Eto
authors.affiliation: Department of Hematology and Oncology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Seki
authors.affiliation: Department of Hematology and Oncology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Nagafuji
authors.affiliation: Department of Hematology, Endocrinology, and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.affiliation: Department of Hematology, Endocrinology, and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takizawa
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Seto
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D015461:Leukemia, Prolymphocytic, T-Cell / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy; D007958:Leukocyte Count; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D011948:Receptors, Antigen, T-Cell
keywords: T-cell prolymphocytic leukemia; overall survival; peripheral T-cell lymphoma, not otherwise specified