title: Computational Analysis of Pumping Efficacy of a Left Ventricular Assist Device according to Cannulation Site in Heart Failure with Valvular Regurgitation.
abstract: Mitral valve regurgitation (MR) causes blood to flow in two directions during contraction of the left ventricle (LV), that is, forward into the aorta and backward into the left atrium (LA). In aortic valve regurgitation (AR), leakage occurs from the aorta into the LV during diastole. Our objective is to analyze the contribution of a left ventricular assist device (LVAD) to MR and AR for the following two different cannulation sites: from the LA to the aorta (LAAO) and from the LV to the aorta (LVAO). Using a computational method, we simulated three ventricular conditions (normal [HF without valvular regurgitation], 5% MR, and 5% AR) in three groups (control [no LVAD], LAAO, and LVAO). The results showed that LVAD with LAAO cannulation is appropriate for recovery of the MR heart, and the LVAD with LVAO cannulation is appropriate for treating the AR heart.
authors.affiliation: Department of IT Convergence Engineering, Kumoh National Institute of Technology, Gumi-si, 39253, Republic of Korea.
authors.forename: Aulia Khamas
authors.identifier: 0000-0001-9452-4064
authors.initials: AK
authors.lastname: Heikhmakhtiar
authors.affiliation: Department of IT Convergence Engineering, Kumoh National Institute of Technology, Gumi-si, 39253, Republic of Korea.
authors.forename: Ki Moo
authors.identifier: 0000-0001-6729-8129
authors.initials: KM
authors.lastname: Lim
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D001011:Aorta / Q000503:physiopathology; D003198:Computer Simulation; D004452:Echocardiography; D006325:Heart Atria / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011312:Pressure; D016277:Ventricular Function, Left
chemical_list: D000255:Adenosine Triphosphate