title: THICKNESS OF THE MACULA, RETINAL NERVE FIBER LAYER, AND GANGLION CELL-INNER PLEXIFORM LAYER IN THE AGE-RELATED MACULAR DEGENERATION: The Repeatability Study of Spectral Domain Optical Coherence Tomography.
abstract: OBJECTIVE
  To determine the repeatability of measuring the thickness of the central macula, retinal nerve fiber layer, and ganglion cell-inner plexiform layer (GC-IPL) using spectral domain optical coherence tomography (Cirrus HD-OCT) in eyes with age-related macular degeneration.
  
  
  METHODS
  One hundred and thirty-four eyes were included. The measurement repeatability was assessed by an experienced examiner who performed two consecutive measurements using a 512 × 128 macular cube scan and a 200 × 200 optic disk cube scan. To assess changes in macular morphology in patients with age-related macular degeneration, the patients were divided into the following three groups according to the central macular thickness (CMT): A group, CMT < 200 μm; B group, 200 μm ≤ CMT < 300 μm; and C group, CMT > 300 μm.
  
  
  RESULTS
  Measurement repeatability was assessed using test-retest variability, a coefficient of variation, and an intraclass correlation coefficient. The mean measurement repeatability for the central macular, retinal nerve fiber layer, and GC-IPL thickness was high in the B group. The mean measurement repeatability for both the central macula and retinal nerve fiber layer thickness was high in the A and C groups, but was lower for the GC-IPL thickness. The measurement repeatability for GC-IPL thickness was high in the B group, but low in the A group and in the C group.
  
  
  CONCLUSIONS
  The automated measurement repeatability for GC-IPL thickness was significantly lower in patients with age-related macular degeneration with out of normal CMT range. The effect of changes in macular morphology should be considered when analyzing GC-IPL thicknesses in a variety of ocular diseases.
authors.affiliation: Department of Ophthalmology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Il-Hwan
authors.initials: IH
authors.lastname: Shin
authors.affiliation: Department of Ophthalmology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Woo-Hyuk
authors.initials: WH
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Jong-Joo
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.|Research Institute for Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Jo
authors.affiliation: Department of Ophthalmology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.|Research Institute for Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Jung-Yeul
authors.initials: JY
authors.lastname: Kim
mesh_terms: D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D057135:Wet Macular Degeneration / Q000175:diagnosis* / Q000503:physiopathology