title: [Annexins in mitochondria].
abstract: Annexins form a family of membrane- and calcium-binding proteins, widely distributed in vertebrates. Their interactions with membranes are regulated by changes of intracellular concentration of calcium ([Ca2+]in.), pH, and the presence of negatively charged phospholipids as well as cholesterol in membranes. As protein participating in membrane fusion and sensors of a [Ca2+]in.Annexins may regulate various signaling pathways including patways involving protein kinase C (PKC isoforms. They also particpate in membrane repair mechanisms (along with actin cytoskeleton and S100 protein), in the vesicular transport (cholesterol enriched domains) as well in in intracellular calcium homeostasis and regulation of mitochondrial function and mitochondrial network structure. The last possibility is a topic of present review commemorating 90th Birthday of Professor Lech Wojtczak.
authors.affiliation: Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteura Street, 02-093 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Bandorowicz-Pikuła
authors.affiliation: Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteura Street, 02-093 Warsaw, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Woś
authors.affiliation: Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteura Street, 02-093 Warsaw, Poland.|Chair of Physics, Warsaw University of Life Sciences-SGGW, 159 Nowoursynowska Street, 02-776 Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sekrecka-Belniak
authors.affiliation: Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteura Street, 02-093 Warsaw, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Pikuła
mesh_terms: D000818:Animals; D017302:Annexins / Q000378:metabolism* / Q000502:physiology; D056890:Eukaryota / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: D017302:Annexins; D024101:Mitochondrial Proteins
keywords: annexins; mitochondria; mitochondrial morphogenesis