title: Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations.
abstract: Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether rs1344706 is associated with schizophrenia in Chinese populations remains inconclusive; furthermore, the association between rs1344706 and BD in Chinese populations has been rarely explored. To explore the association between rs1344706 and schizophrenia/BD in Chinese populations, we genotyped rs1344706 among 1128 Chinese subjects (537 patients with BD and 591 controls) and found that rs1344706 showed marginal allelic association with BD (P = 0.028) with T-allele being more prevalent in cases than that in controls (OR = 1.19, 95% CI 1.03-1.37). Meta-analysis of rs1344706 by pooling all available data showed that rs1344706 was significantly associated with BD (P = 0.001). Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005). Furthermore, ZNF804A is highly expressed in human and mouse brains, especially in prenatal stage.
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
authors.forename: Shuquan
authors.initials: S
authors.lastname: Rao
authors.affiliation: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Disease Epigenetics Group, Murdoch Children's Research Institute, &Department of Paediatrics, University of Melbourne, 3052 Parkville, Australia.|Inserm, U1061, Univ Montpellier, Montpellier, France.
authors.forename: Joanne
authors.initials: J
authors.lastname: Ryan
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jin
authors.affiliation: Department of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical University, Taiyuan, 030000, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
authors.forename: Xinhe
authors.initials: X
authors.lastname: Huang
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
authors.forename: Yueqiang
authors.initials: Y
authors.lastname: Wen
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
authors.forename: Canquan
authors.initials: C
authors.lastname: Mao
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON L8N 3Z5, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Meyre
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human