title: Superficial vein thrombosis in non-varicose veins of the lower limbs and thrombophilia.
abstract: Objectives Superficial vein thrombosis in non-varicose veins of the lower limbs is rather frequent and may be underestimated. This study aims to evaluate the prevalence of inherited or acquired thrombophilia in a sample of outpatients with the disease. Method An observational study was conducted on 73 consecutive superficial vein thrombosis patients tested for inherited or acquired thrombophilia. Results Sixty of 73 patients with superficial vein thrombosis completed the testing protocol, while 13 dropped out; 46 of 60 patients were found to have a thrombophilia (76.6%). The types detected were: factor V Leiden (31/60, i.e. 51.6%), prothrombin mutation (2/60, i.e. 3.3%), MTHFR mutation (23/60, i.e. 38.3%), antiphospholipid antibodies (5/60, i.e. 8.3%), protein C deficit (1/60, i.e. 1.6%), protein S deficit (1/60, i.e. 1.6%), and antithrombin deficit (0/60, i.e. 0%). Conclusions Among patients with superficial vein thrombosis in non-varicose veins, testing demonstrated a high prevalence of thrombophilia. The most common form proved to be factor V Leiden. As thrombophilia was found to be a major cause of superficial vein thrombosis in non-varicose veins, the authors recommend that patients with superficial vein thrombosis in non-varicose veins be investigated for thrombophilia.
authors.affiliation: J. F. Merlen Research Center for Vascular Diseases, Frosinone, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lucchi
authors.affiliation: J. F. Merlen Research Center for Vascular Diseases, Frosinone, Italy.
authors.forename: Salvino
authors.initials: S
authors.lastname: Bilancini
authors.affiliation: J. F. Merlen Research Center for Vascular Diseases, Frosinone, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Tucci
authors.affiliation: J. F. Merlen Research Center for Vascular Diseases, Frosinone, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Lucchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid; D005165:Factor V / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D011516:Prothrombin / Q000235:genetics / Q000378:metabolism; D019851:Thrombophilia / Q000097:blood / Q000150:complications / Q000235:genetics; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology / Q000235:genetics
chemical_list: D017152:Antibodies, Antiphospholipid; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Thrombophilia; non-varicose veins; superficial vein thrombosis