title: Chlorogenic acid from coffee beans: evaluating the evidence for a blood pressure-regulating health claim.
abstract: The consumption of coffee has been associated with a number of health benefits, including a reduced risk of cardiovascular disease. Hypertension is an important risk factor for adverse cardiovascular events. Coffee may help reduce blood pressure (BP) in humans, which might be attributable to its polyphenolic compound, chlorogenic acid. The high incidence of hypertension among Canadians underscores the need for new and effective strategies to reduce BP. Dietary interventions may constitute such a strategy, but consumers need to be informed about which foods are most effective for regulating BP. To guide healthy eating, Health Canada permits the use of health claims on the labels of foods that confer health benefits. Currently, there is only one health claim for BP regulation. Additional health claims for foods that assist in BP regulation are therefore warranted. This review provides background information on chlorogenic acid and examines the evidence regarding the use of chlorogenic acid for BP regulation in the context of Health Canada's health claims framework.
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St-Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
authors.forename: Tara B
authors.initials: TB
authors.lastname: Loader
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St-Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
authors.forename: Carla G
authors.initials: CG
authors.lastname: Taylor
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St-Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Zahradka
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.|Department of Food Science, University of Manitoba, and the Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, Manitoba, Canada.
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Jones
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002170:Canada / Q000453:epidemiology; D002478:Cells, Cultured; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003069:Coffee / Q000737:chemistry*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology*; D015994:Incidence; D008019:Life Style; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D003069:Coffee; D002726:Chlorogenic Acid
keywords: blood pressure; chlorogenic acid; coffee; health claim; hypertension