title: Clear Cell Carcinoma of the Cervix With Choriocarcinomatous Differentiation: Report of an Extremely Rare Phenomenon Associated With Mismatch Repair Protein Abnormality.
abstract: The presence of trophoblastic differentiation or nongestational choriocarcinoma in a carcinoma is rare but has been described in various organs, including in the female genital tract. We report a cervical clear cell carcinoma admixed with a component of choriocarcinoma in a 52-year-old woman, only the second report of this combination in the literature. Immunohistochemically, the tumor exhibited isolated loss of staining with the mismatch repair protein MSH6. We review the literature on trophoblastic differentiation in cervical carcinoma.
authors.affiliation: Department of Cellular Pathology (P.M.), Royal United Hospital, Bath, England Department of Pathology (W.G.M.), Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
authors.forename: Pinias
authors.initials: P
authors.lastname: Mukonoweshuro
authors.forename: W Glenn
authors.initials: WG
authors.lastname: McCluggage
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D002822:Choriocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D053843:DNA Mismatch Repair; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000172:deficiency; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D014327:Trophoblasts / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014599:Uterus / Q000473:pathology
chemical_list: D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein