title: THE EFFECT OF EXTRACT OF GREEK WALNUT (JUGLANS REGIA L.) SEPTA ON SOME FUNCTIONAL CHARACTERISTICS OF ERYTHROCYTES.
abstract: Administration of plant extracts for the treatment of several different diseases is an important approach ofmodern medicine.The reason must be an easy way of application, low price and the complex action of herbal medicines. The aim of the work was to study the effect of extract of walnut (Juglans regia L.) septa on the functional characteristics of erythrocytes during administration of cytotoxic agent - cyclophosphamide (experimental model of leukopenia). The material for the study was blood of the intact and experimental white mice. Sorption capacity and resistance to lysis of erythrocyte membrane have been determined by the spectrophotometric methods. According to the gained results, administration of cyclophosphamide had an influence on sorption capacity of erythrocytes and the given characteristic was increased only on the 8th day of cyclophosphamide administration, compared to control. Sorption capacity of erythrocytes was increased more on 8th day after combined application of cyclophosphamide and exctract of walnut septa. Resistance of erythrocytes to lysis was also increased after administration of the cyclophosphamide and this characteristic was further increased in case of combined application of cyclophosphamide and exctract of walnut septa. Thus, the stimulative effects of extract of walnut septa have been established on sorption capacity and resistance to lysis of erythrocytes in case of nonspecific damage of the cells.
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Faculty of Exact and Natural Sciences, Department of Biology, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Ramishvili
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Faculty of Exact and Natural Sciences, Department of Biology, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Gordeziani
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Faculty of Exact and Natural Sciences, Department of Biology, Georgia.
authors.forename: E
authors.initials: E
authors.lastname: Tavdishvili
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Faculty of Exact and Natural Sciences, Department of Biology, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Bedineishvili
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Faculty of Exact and Natural Sciences, Department of Biology, Georgia.
authors.forename: D
authors.initials: D
authors.lastname: Dzidziguri
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Faculty of Exact and Natural Sciences, Department of Biology, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Kotrikadze
mesh_terms: D000327:Adsorption; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology; D006461:Hemolysis / Q000187:drug effects; D031324:Juglans / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D003520:Cyclophosphamide