title: Association Between IL-18 and Carotid Intima-Media Thickness in Patients with Type II Diabetic Nephropathy.
abstract: BACKGROUND We specifically designed this study to determine the relationship between levels of IL-8 and carotid intima-media thickness (cIMT) in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS A total of 149 diabetic patients at different stages of diabetic nephropathy and 72 matched controls were recruited in this study. A wide range of parameters were measured: IL-18 (by ELISA), urinary albumin excretion rates (UAER), and carotid intima-media thickness (cIMT, by pulse wave velocity [PWV]). All the diabetic patients were treated by alprostadil. RESULTS ELISA indicated that the level of IL-18 in the patient group was significantly higher compared with that in the control group. The level of IL-18 apparently increased in the higher cIMT group in T2DM patients. Serum IL-18 levels were positively correlated with cIMT in patients with T2DM, the level of IL-18 was negatively correlated with cIMT, and IL-18 levels were positively correlated to age. Moreover, IMT was positively correlated with hemoglobin A1C (HbA1C) and IL-18 levels were significantly associated with cIMT (all P<0.05). CONCLUSIONS IL-18 levels were positively correlated with atherosclerotic burden in patients with T2DM and it may be considered as a significant therapeutic target.
authors.affiliation: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong, China (mainland).
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Linyi People's Hospital, Linyi, Shandong, China (mainland).
authors.forename: Haomiao
authors.initials: H
authors.lastname: Feng
authors.affiliation: Department of Pathology, Linyi People's Hospital, Linyi, Shandong, China (mainland).
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wei
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use; D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000473:pathology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C000589760:IL18 protein, human; D020382:Interleukin-18; D000527:Alprostadil