title: Xenorhabdus stockiae KT835471-mediated feasible biosynthesis of metal nanoparticles for their antibacterial and cytotoxic activities.
abstract: In this study, extracellular metabolites of symbiotic bacteria Xenorhabdus stockiae (KT835471) was employed for the synthesis of silver (XsAgNPs) and gold nanoparticles (XsAuNPs). Synthesized NPs were characterized using high throughput instrumentation which confirms the generation of stable, crystalline XsAgNPs and XsAuNPs with the mean size of 14 ± 6 and 14 ± 5, respectively. Further, the NPs exhibits an excellent bactericidal effect against six different pathogens. On the other hand, NPs displayed an outstanding anticancer activity against human lung adenocarcinoma epithelial cells (A549). Therefore, the present study strongly suggests that metal NPs encrusted with functional bio-moieties can be used for different biomedical applications.
authors.affiliation: a Department of Biotechnology , Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.
authors.forename: Gobinath
authors.initials: G
authors.lastname: Chandrakasan
authors.affiliation: a Department of Biotechnology , Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.
authors.forename: PrabuKumar
authors.initials: P
authors.lastname: Seetharaman
authors.affiliation: a Department of Biotechnology , Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.
authors.forename: Sathishkumar
authors.initials: S
authors.lastname: Gnanasekar
authors.affiliation: b Thiruvalluvar University , Vellore , Tamil Nadu , India.
authors.forename: Murugan
authors.initials: M
authors.lastname: Kadarkarai
authors.affiliation: a Department of Biotechnology , Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.
authors.forename: Sivaramakrishnan
authors.initials: S
authors.lastname: Sivaperumal
mesh_terms: D000072283:A549 Cells; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D005240:Feasibility Studies; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D020593:Xenorhabdus / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D012834:Silver; D006046:Gold
keywords: X-ray diffraction; Xenorhabdus stockiae KT835471; apoptosis; lung cancer; metal nanoparticles