title: A review on nanoparticle-based technologies for biodetoxification.
abstract: Nanotechnology has gained significant penetration to different fields of medicine including drug delivery, disease interrogation, targeting and bio-imaging. In recent years, efforts have been put forth to assess the use of this technology in biodetoxification. In this review, we will discuss the current status of nanostructured biomaterials/nanoparticle (NP)-based technologies as a candidate biodetoxifying agent. Patient hospitalization due to illicit drug consumption, suicidal attempts and accidental toxin exposure are major challenges in the medical field. Overdoses of drugs/toxic chemicals or exposure to bacterial toxins or poisons are conventionally treated by voiding the stomach, administering activated charcoal or by using specific antidotes, if the toxin is known. Because of the limitations of these methods for safe and effective detoxification, advancements in nanotechnology may offer novel ways in intoxication support by using nanostructured biomaterials, such as liposomes, micellar nanocarriers, liquid crystalline nanoassemblies and ligand-based NPs.
authors.affiliation: a Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture , Faisalabad , Pakistan , and.
authors.forename: Faqir
authors.initials: F
authors.lastname: Muhammad
authors.affiliation: b Nanotechnology Innovation Center of Kansas State, Department of Chemistry, Kansas State University , Manhattan , KS , USA.
authors.forename: Tuyen Duong Thanh
authors.initials: TDT
authors.lastname: Nguyen
authors.affiliation: a Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture , Faisalabad , Pakistan , and.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Raza
authors.affiliation: a Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture , Faisalabad , Pakistan , and.
authors.forename: Bushra
authors.initials: B
authors.lastname: Akhtar
authors.affiliation: b Nanotechnology Innovation Center of Kansas State, Department of Chemistry, Kansas State University , Manhattan , KS , USA.
authors.forename: Santosh
authors.initials: S
authors.lastname: Aryal
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000009:adverse effects; D016503:Drug Delivery Systems / Q000009:adverse effects; D015195:Drug Design; D062787:Drug Overdose / Q000628:therapy*; D015507:Drugs, Investigational / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D053769:Nanocapsules / Q000009:adverse effects / Q000627:therapeutic use; D053761:Nanocomposites / Q000009:adverse effects / Q000627:therapeutic use; D053758:Nanoparticles / Q000009:adverse effects / Q000627:therapeutic use*; D036103:Nanotechnology / Q000639:trends; D011041:Poisoning / Q000628:therapy*; D061905:Single-Domain Antibodies / Q000009:adverse effects / Q000627:therapeutic use; D016060:Sorption Detoxification / Q000009:adverse effects / Q000639:trends
chemical_list: D001672:Biocompatible Materials; D015507:Drugs, Investigational; D053769:Nanocapsules; D061905:Single-Domain Antibodies
keywords: Nanotechnology; biodetoxification; ligand-based nanoparticles; liposomes; micellar nanocarriers