title: Understanding the Impact of Stroke on Brain Motor Function: A Hierarchical Bayesian Approach.
abstract: Stroke is a disturbance in blood supply to the brain resulting in the loss of brain functions, particularly motor function. A study was conducted by the UCI Neurorehabilitation Lab to investigate the impact of stroke on motor-related brain regions. Functional MRI (fMRI) data were collected from stroke patients and healthy controls while the subjects performed a simple motor task. In addition to affecting local neuronal activation strength, stroke might also alter communications (i.e., connectivity) between brain regions. We develop a hierarchical Bayesian modeling approach for the analysis of multi-subject fMRI data that allows us to explore brain changes due to stroke. Our approach simultaneously estimates activation and condition-specific connectivity at the group level, and provides estimates for region/subject-specific hemodynamic response functions. Moreover, our model uses spike and slab priors to allow for direct posterior inference on the connectivity network. Our results indicate that motor-control regions show greater activation in the unaffected hemisphere and the midline surface in stroke patients than those same regions in healthy controls during the simple motor task. We also note increased connectivity within secondary motor regions in stroke subjects. These findings provide insight into altered neural correlates of movement in subjects who suffered a stroke.
authors.affiliation: Department of Statistics, University of California at Irvine.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Applied Mathematics & Statistics, University of California at Santa Cruz.
authors.forename: Raquel
authors.initials: R
authors.lastname: Prado
authors.affiliation: Department of Anatomy & Neurobiology, University of California at Irvine.
authors.forename: Erin B
authors.initials: EB
authors.lastname: Quinlan
authors.affiliation: Department of Neurobiology, University of California at Irvine.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Cramer
authors.affiliation: Department of Statistics, University of California at Irvine.
authors.forename: Hernando
authors.initials: H
authors.lastname: Ombao
keywords: activation; connectivity; fMRI; multi-subject