title: Association ofMTHFRC677T and A1298C polymorphisms with oral cancer susceptibility: evidence from a meta-analysis.
abstract: Methylenetetrahydrofolate reductase (MTHFR) is a central enzyme involved in folate metabolism and plays an important role in DNA synthesis and methylation. Several studies have been conducted to illustrate the associations betweenMTHFRC677T and A1298C polymorphisms with oral cancer susceptibility; however, the results are inconsistent. Therefore, we conducted an updated meta-analysis to obtain a more reliable estimation of the associations. We retrieved eligible studies from PubMed, EMBASE, and CBM databases through September 2016. Ultimately, pooled analyses involved 10 studies with 1443 cases and 1640 controls for the C677T polymorphism, as well as five studies with 973 cases and 1024 controls for the A1298C polymorphism. Risk estimates were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs). Pooled results indicated that neither C677T nor A1298C polymorphism was associated with oral cancer susceptibility. However, a borderline significant association was detected betweenMTHFRC677T polymorphism and a decreased oral cancer risk (homozygous model: OR=0.71, 95% CI=0.50-1.00) in hospital-based studies. Our results suggested thatMTHFRC677T and A1298C polymorphisms might not be associated with oral cancer risk. However, more evidence is needed to further confirm these findings in the future.
authors.affiliation: Department of Oral and Maxillofacial Surgery.
authors.forename: Sui
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong.
authors.forename: Jin-Dong
authors.initials: JD
authors.lastname: Xu
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Zhen-Jian
authors.initials: ZJ
authors.lastname: Zhuo
authors.affiliation: Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong.
authors.forename: Zhu-Ming
authors.initials: ZM
authors.lastname: Hua
keywords: MTHFR; meta-analysis; oral cancer; polymorphisms; susceptibility