title: SUMO and the robustness of cancer.
abstract: Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.
authors.affiliation: Nuclear Organization and Oncogenesis Unit, INSERM U993, Institut Pasteur, 28 rue de Dr Roux, 75724 Paris Cedex 15, France.
authors.forename: Jacob-Sebastian
authors.initials: JS
authors.lastname: Seeler
authors.affiliation: Nuclear Organization and Oncogenesis Unit, INSERM U993, Institut Pasteur, 28 rue de Dr Roux, 75724 Paris Cedex 15, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Dejean
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D016922:Cellular Senescence; D004249:DNA Damage; D019008:Drug Resistance, Neoplasm; D005786:Gene Expression Regulation; D006801:Humans; D016328:NF-kappa B / Q000502:physiology; D009369:Neoplasms / Q000209:etiology*; D025842:SUMO-1 Protein / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D058207:Sumoylation
chemical_list: D016328:NF-kappa B; D025842:SUMO-1 Protein