title: A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series.
abstract: BACKGROUND
  Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the study was to evaluate the efficacy of PDT in the treatment of EOLP.
  
  
  METHODS
  Twelve female patients aged 63-80 with 22 OLP lesions (16 on the buccal mucosa, 6 on gingiva and tongue), underwent authors' own PDT scheme with the use of 5% solution of 5-aminolevulinic acid (ALA) as photosensitizer. An ALA-saturated occlusive dressing was applied directly onto a lesion and surrounding mucosa 2h prior to illumination with a custom-made diode lamp (light of 630nm, dose of 300mW). After a series of 10 weekly illumination sessions the patients were monitored for 12 months.
  
  
  RESULTS
  The mean size of lesions before treatment was 1.46cm2±1.44. The lesions on the buccal mucosa were smaller (1.06cm2±0.98) than those on the gingiva and tongue (2.63cm2±1.93). Post-treatment improvement encompassed 16 lesions, 5 of which were in remission. The mean reduction in size after 10-session therapy was 8,05%. The healing continued and further reduction in size (by 69.13%) took place during the 12-month observation: 39.62% of lesions within the buccal mucosa and full remission of all lesions on the gingiva and tongue.
  
  
  CONCLUSIONS
  The results suggest that PDT offers non-invasive treatment of lesions in oral mucosa and may become an alternative and complementary method to those currently in use. Further studies involving larger groups of patients should be undertaken before it becomes routine practice.
authors.affiliation: Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269 Białystok, Poland. Electronic address: cholewa.magda@gmail.com.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Sulewska
authors.affiliation: Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269 Białystok, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Duraj
authors.affiliation: Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269 Białystok, Poland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Sobaniec
authors.affiliation: Laboratory of Biochemistry and Spectroscopy, Institute of Oploelectronics Military Academy of Technology in Warsaw, ul. gen. Sylwestra Kaliskiego 2, 00-908 Warszawa, Poland.
authors.forename: Alfreda
authors.initials: A
authors.lastname: Graczyk
authors.affiliation: Department of Statistics and Medical Informatics Medical University of Białystok, ul. Szpitalna 37, 15-295 Białystok, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Milewski
authors.affiliation: Dental Practice, ul. Kardynała Wyszyńskiego 16, 18-400 Łomża, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Wróblewska
authors.affiliation: Dental Practice, ul. Waszyngtona 1/34, 15-269 Białystok, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Pietruski
authors.affiliation: Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269 Białystok, Poland; Dental Practice, ul. Waszyngtona 1/34, 15-269 Białystok, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pietruska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D021542:Amino Acids, Neutral / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D021542:Amino Acids, Neutral; D017319:Photosensitizing Agents; C013809:5-aminovaleric acid
keywords: Erosive oral lichen planus; Photodynamic therapy