title: [A study of the association between the kynurenine-3-monooxygenase gene and depression].
abstract: OBJECTIVE
  To study the association between the kynurenine 3-monooxygenase (KMO) and depression.
  
  
  METHODS
  КМО rs2275163 (C/T) and rs1053230 (A /G) polymorphisms were genotyped in patients diagnosed with depression (the main group) and age - and sex-matched healthy people.
  
  
  RESULTS
  The rs2275163 polymorphism was not associated with depression. There was the association between the rs1053230 polymorphism and depression. The frequency of the low expression genotype GG was higher in the main group compared to controls (р=0.001, ОШ 2.8 (95% ДИ 1.73-4.24). This genotype was earlier reported to be associated with the increased levels of kynurenic acid in patients with bipolar disorders.
  
  
  CONCLUSIONS
  The genotype GG can be considered as a risk factor of depression.
authors.affiliation: Research Center of Mental Health, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Lezheiko
authors.affiliation: Research Center of Mental Health, Moscow, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Andryushchenko
authors.affiliation: Geratzy Yerevan State Medical University, Erevan, Armenia.
authors.forename: A E
authors.initials: AE
authors.lastname: Melik-Pashayan
authors.affiliation: Geratzy Yerevan State Medical University, Erevan, Armenia.
authors.forename: E V
authors.initials: EV
authors.lastname: Mironova
mesh_terms: D000328:Adult; D000483:Alleles; D003863:Depression / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007736:Kynurenic Acid / Q000378:metabolism; D050601:Kynurenine 3-Monooxygenase / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D050601:Kynurenine 3-Monooxygenase; D007736:Kynurenic Acid