title: Microvascular function in women with former gestational diabetes: A cohort study.
abstract: In the long term, diabetes mellitus is potentially associated with the occurrence of microvascular damage. This study sought to assess whether a history of prior gestational diabetes mellitus is associated with long-term effects on the women's microcirculation.
  
  
  
  Within the scope of a long-term follow-up of the 'Viennese Post-Gestational Diabetes Project', women with prior gestational diabetes mellitus as well as women with previous pregnancy but with no history of gestational diabetes mellitus (controls) were enrolled in this cross-sectional study. Microvascular function was assessed by post-occlusive reactive hyperaemia using laser Doppler fluxmetry. Baseline perfusion, biological zero, peak perfusion, time to peak and recovery time were recorded and compared between both groups.
  
  
  
  Microvascular function was assessed in 55 women with prior gestational diabetes mellitus (46.1 ± 4.6 years) and 32 women with previous pregnancy but without prior gestational diabetes mellitus (42.9 ± 5.3 years). The mean period of time between delivery and the assessment of microvascular function was 16.2 ± 5.2 years in women with prior gestational diabetes mellitus group and 14.2 ± 4.8 years in controls. Regarding microvascular function, baseline perfusion, biological zero, peak perfusion, time to peak and recovery time did not differ between women with prior gestational diabetes mellitus and controls (all p > 0.05).
  
  
  
  In the long term, microvascular function appears not to be impaired in women with prior gestational diabetes mellitus.
authors.affiliation: 1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.|2 Cardiology and Intensive Care Medicine, Department of Medicine II, Klinikum Wels-Grieskirchen, Wels, Austria.
authors.forename: Silvia
authors.initials: S
authors.lastname: Charwat-Resl
authors.affiliation: 3 Gender Medicine Unit, Division of Endocrinology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Rajashri
authors.initials: R
authors.lastname: Yarragudi
authors.affiliation: 1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
authors.forename: Moritz
authors.initials: M
authors.lastname: Heimbach
authors.affiliation: 3 Gender Medicine Unit, Division of Endocrinology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Karoline
authors.initials: K
authors.lastname: Leitner
authors.affiliation: 3 Gender Medicine Unit, Division of Endocrinology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Leutner
authors.affiliation: 4 Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
authors.forename: Jutta
authors.initials: J
authors.lastname: Gamper
authors.affiliation: 1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
authors.forename: Georgiana-Aura
authors.initials: GA
authors.lastname: Giurgea
authors.affiliation: 1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Mueller
authors.affiliation: 1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
authors.forename: Renate
authors.initials: R
authors.lastname: Koppensteiner
authors.affiliation: 1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Gschwandtner
authors.affiliation: 3 Gender Medicine Unit, Division of Endocrinology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kautzky-Willer
authors.affiliation: 1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
authors.forename: Oliver
authors.initials: O
authors.lastname: Schlager
mesh_terms: D000328:Adult; D001317:Austria; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation; D055806:Microvessels / Q000503:physiopathology*; D008875:Middle Aged; D011247:Pregnancy; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: Gestational diabetes; laser Doppler; microangiopathy; microcirculation