title: [Radical Chemoradiotherapy for Recurrent Esophageal Cancer after Curative Esophagectomy].
abstract: Recurrent esophageal cancer has a poor prognosis.However, we sometimes encounter cases with long-term survival after radical treatment for recurrent esophageal cancer.We perform radical chemoradiotherapy aggressively when recurrent esophageal cancer is present in a limited area and is sufficiently localized to be treated by radiation therapy.From June 2010 to December 2014, 150 patients underwent curative esophagectomy for esophageal cancer.Forty -one cases relapsed and we treated 13 of them with radical chemoradiotherapy.Complete response(CR), non-CR/non-PD, and progressive disease(PD) were observed in 5, 6, and 2 cases, respectively.The CR rate was 38.4%.The median survival time from recurrence was 500± 39.7 days, and the 1-year and 3-year survival rates were 84.6% and 28.7%, respectively. Four out of 5 CR cases were single site recurrences.The other case was multiple and regrowth of the cancer was identified 253 days after the CR.These results suggest that radical chemoradiotherapy for recurrent esophageal cancer after curative esophagectomy can achieve long time survival, especially in cases with single site lymph node recurrence.
authors.affiliation: Dept. of Gastrointestinal Surgery, Kanagawa Cancer Center.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogata
authors.forename: Takuma
authors.initials: T
authors.lastname: Nomiya
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nonaka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kano
authors.forename: Yukio
authors.initials: Y
authors.lastname: Maezawa
authors.forename: Kenki
authors.initials: K
authors.lastname: Segami
authors.forename: Kousuke
authors.initials: K
authors.lastname: Ikeda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Cho
authors.forename: Takaki
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D004938:Esophageal Neoplasms / Q000628:therapy*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016896:Treatment Outcome