title: Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer.
abstract: OBJECTIVE
  In order to summarize the role of exosomes in invasion and metastasis in gastric cancer (GC).
  
  
  METHODS
  Exosomes are vesicles of endocytic origin ranging from 30 to 100 nm in size; they are composed of a lipid bilayer and contain DNA, mRNA, miRNA, circular RNA and multiple proteins. Recently, increasing evidence shows that exosomes play a crucial role in the tumorigenesis of GC.
  
  
  RESULTS
  In this review, we focus on the latest findings on GC exosomes, mainly summarizing their role in invasion and metastasis in GC. Then, exosomes? potential functions as novel diagnostic and therapeutic biomarkers for GC are briefly discussed. At last, we prospect the clinical application perspective of exosomes in GC.
  
  
  CONCLUSIONS
  Exosomes play a vital role in gastric cancer carcinogenesis and metastasis.
authors.affiliation: a Department of Clinical Laboratory , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China.|b Department of Clinical Laboratory, Key Clinical Laboratory of Henan Province , Zhengzhou , PR China.
authors.forename: Yunmeng
authors.initials: Y
authors.lastname: Yan
authors.affiliation: a Department of Clinical Laboratory , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China.|b Department of Clinical Laboratory, Key Clinical Laboratory of Henan Province , Zhengzhou , PR China.
authors.forename: Guangzhen
authors.initials: G
authors.lastname: Fu
authors.affiliation: a Department of Clinical Laboratory , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China.|b Department of Clinical Laboratory, Key Clinical Laboratory of Henan Province , Zhengzhou , PR China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Ye
authors.affiliation: a Department of Clinical Laboratory , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China.|b Department of Clinical Laboratory, Key Clinical Laboratory of Henan Province , Zhengzhou , PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ming
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D063646:Carcinogenesis / Q000187:drug effects / Q000473:pathology*; D019008:Drug Resistance, Neoplasm; D055354:Exosomes / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D009362:Neoplasm Metastasis; D012313:RNA / Q000378:metabolism; D000079962:RNA, Circular; D012333:RNA, Messenger / Q000378:metabolism; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D035683:MicroRNAs; D000079962:RNA, Circular; D012333:RNA, Messenger; D012313:RNA
keywords: Exosomes; chemotherapy; gastric cancer; invasion; metastasis