title: Clinicopathological profile of gastrointestinal lymphomas in Kashmir.
abstract: BACKGROUND
  The histological categorization of lymphoma has been a source of controversy for many years for both clinicians and pathologists. Clinicopathologic information of gastrointestinal lymphomas in Indian subcontinent is lacking. We studied histopathological spectrum of Primary Gastrointestinal Lymphomas (PGIL) and attempted to classify the G.I. lymphomas based on the recent WHO classification in to major histological types and immunological categories.
  
  
  METHODS
  This study was done to evaluate the clinicopathological pattern of 100 cases with a histopathological diagnosis of primary gastrointestinal lymphoma at a tertiary care hospital. All patients of primary gastrointestinal lymphomas were included with the help of medical records over a 11-years period that is, January 2005 to December 2015.
  
  
  RESULTS
  The study included 100 cases (60 males, 40 females; mean age 51.43 years; age range 4.5-90 years). The disease involved stomach in 82 (82%), small intestine in 8 (8%), large bowel and rectum in 8 (8%), gall bladder in 1 (1%) and oesophagus in 1 (1%). 82 (82%) of the 100 cases were Diffuse Large B cell lymphomas; 12 (12%) were Extra Nodal Marginal Zone Lymphomas (ENMZL of MALT type) 2 (2%) IPSID 2 (2%) of Mantle cell lymphoma morphology, 1 (1%) Burkitt's and 1(1%) enteropathy associated T cell lymphoma. The commonest presenting symptom was abdominal pain. 99 (99%) of 100 tumours were classified as B-cell lymphomas immunohistochemically and majority exhibited monoclonal light chain restriction on kappa/lambda staining. In addition; Burkitt's lymphoma showed positivity for CD 10. One tumour (1%) showed positivity for T-cell markers. The data demonstrated that primary GI NHL is more common among males, mainly in their fifth decade. Abdominal pain is the most common presenting symptom, with stomach being the most commonly involved site. Diffuse large cell lymphoma is the most frequent histologic subtype, followed by extranodal marginal-zone B cell lymphoma (MALT type).H. Pyloriinfection was observed in cases with low grade MALT lymphomas. Striking was the observation of two cases of IPSID (a disease commonly found in Mediterranean countries) and one case of enteropathy associated T cell lymphoma.
  
  
  CONCLUSIONS
  EGD, imaging, light microscopic examination and immunohistochemical workup for B and T cell markers and staining for light chains to assist documentation of monoclonality are of precise diagnostic value in gastrointestinal lymphomas and form a part of the diagnostic workup.
authors.affiliation: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Mehnaaz Sultan
authors.initials: MS
authors.lastname: Khuroo
authors.affiliation: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Summyia Farooq
authors.initials: SF
authors.lastname: Khwaja
authors.affiliation: Department of Surgery, SKIMS Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Ajaz
authors.initials: A
authors.lastname: Rather
authors.affiliation: Department of Endocrinology, SKIMS Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Zhahid
authors.initials: Z
authors.lastname: Hassan
authors.affiliation: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Ruby
authors.initials: R
authors.lastname: Reshi
authors.affiliation: Dr Khuroo's Medical Clinic, Srinagar, Jammu and Kashmir, India.
authors.forename: Naira Sultan
authors.initials: NS
authors.lastname: Khuroo
keywords: Lymphoma; non-Hodgkin lymphoma; primary GIT