title: Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma.
abstract: Investigation of cyclooxygenase (COX)-2 in dentigerous cyst and ameloblastoma may help to improve understanding of the nature and behavior of odontogenic cysts and tumors, and in addition may eventually represent a definitive target for a pharmacological approach in the management of these lesions. The aim of this study was to evaluate COX-2 expression and its correlation with the proliferation of odontogenic epithelium in these lesions. Dentigerous cysts (n=16) and ameloblastomas (n=17) were evaluated. Detection of Ki-67 and COX-2 protein expression was conducted by immunohistochemistry. Data were statistically analyzed using Mann-Whitney U test and Spearman's rank correlation coefficient. No significant differences were found in the expression of Ki-67 and COX-2 between dentigerous cysts and ameloblastomas (P>0.05). A significant positive correlation (P=0.018) and highly significant positive correlation (P=0.004) were found between Ki-67 and COX-2 expression in the odontogenic epithelium of dentigerous cyst and ameloblastoma, respectively. COX-2 was expressed in the odontogenic epithelium of dentigerous cyst and ameloblastoma. It may contribute to local extension of these lesions by increasing the proliferation of their odontogenic epithelial cells.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China; Department of Oral and Maxillofacial Surgery, College of Dentistry, Ajman University, Al-Hulifat, Fujairah 2202, UAE; Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul, Mosul, Ninavah 41002, Iraq.
authors.forename: Mohammed Amjed
authors.initials: MA
authors.lastname: Alsaegh
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China; Department of Oral Medicine and Surgery, Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyashita
authors.affiliation: Department of Oral Medicine and Surgery, Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Taniguchi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
authors.forename: Sheng Rong
authors.initials: SR
authors.lastname: Zhu
keywords: Ki-67; ameloblastoma; cyclooxygenase-2; dentigerous cyst; proliferation