title: Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases.
abstract: Calcitonin gene-related peptide (CGRP) is a 37-amino-acid neuropeptide belonging to the calcitonin gene peptide superfamily. CGRP is a potent vasodilator with potential therapeutic usefulness for treating vascular-related disease. This peptide is primarily located on C- and Aδ-fibers, which have extensive perivascular presence and a dual sensory-efferent function. Although CGRP has two major isoforms (α-CGRP andβ-CGRP), theα-CGRP is the isoform related to vascular actions. Release of CGRP from afferent perivascular nerve terminals has been shown to result in vasodilatation, an effect mediated by at least one receptor (the CGRP receptor). This receptor is an atypical G-protein coupled receptor (GPCR) composed of three functional proteins: (i) the calcitonin receptor-like receptor (CRLR; a seven-transmembrane protein), (ii) the activity-modifying protein type 1 (RAMP1), and (iii) a receptor component protein (RCP). Although under physiological conditions, CGRP seems not to play an important role in vascular tone regulation, this peptide has been strongly related as a key player in migraine and other vascular-related disorders (e.g., hypertension and preeclampsia). The present review aims at providing an overview on the role of sensory fibers and CGRP release on the modulation of vascular tone.
authors.affiliation: Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, 76230 Santiago de Querétaro, QRO, Mexico.
authors.forename: Abimael
authors.identifier: 0000-0002-6472-1419
authors.initials: A
authors.lastname: González-Hernández
authors.affiliation: Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN-Sede Sur, 14330 Mexico City, Mexico.
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Marichal-Cancino
authors.affiliation: Departamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología, Secretaría de Salud, 11000 Mexico City, Mexico.
authors.forename: Jair
authors.initials: J
authors.lastname: Lozano-Cuenca
authors.affiliation: Departamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología, Secretaría de Salud, 11000 Mexico City, Mexico.
authors.forename: Jorge S
authors.initials: JS
authors.lastname: López-Canales
authors.affiliation: Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, 88740 Reynosa, TAMPS, Mexico.
authors.forename: Enriqueta
authors.initials: E
authors.lastname: Muñoz-Islas
authors.affiliation: Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, 88740 Reynosa, TAMPS, Mexico.
authors.forename: Martha B
authors.initials: MB
authors.lastname: Ramírez-Rosas
authors.affiliation: Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN-Sede Sur, 14330 Mexico City, Mexico.
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Villalón
mesh_terms: D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D019317:Evidence-Based Medicine; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy / Q000379:methods; D000069336:Neurovascular Coupling / Q000502:physiology*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism*; D014652:Vascular Diseases / Q000188:drug therapy* / Q000378:metabolism*; D014664:Vasodilation / Q000502:physiology*
chemical_list: D018015:Receptors, Calcitonin Gene-Related Peptide; D015740:Calcitonin Gene-Related Peptide