title: [18F]FDG PET signal is driven by astroglial glutamate transport.
abstract: Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [18F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [18F]FDG signal.
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging (MCSA), Douglas Mental Health University Institute, Departments of Neurology and Neurosurgery, Psychiatry, and Pharmacology, McGill University, Montreal, Canada.|Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Eduardo R
authors.initials: ER
authors.lastname: Zimmer
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging (MCSA), Douglas Mental Health University Institute, Departments of Neurology and Neurosurgery, Psychiatry, and Pharmacology, McGill University, Montreal, Canada.
authors.forename: Maxime J
authors.initials: MJ
authors.lastname: Parent
authors.affiliation: Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.|Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Débora G
authors.initials: DG
authors.lastname: Souza
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging (MCSA), Douglas Mental Health University Institute, Departments of Neurology and Neurosurgery, Psychiatry, and Pharmacology, McGill University, Montreal, Canada.
authors.forename: Antoine
authors.initials: A
authors.lastname: Leuzy
authors.affiliation: Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Canada.
authors.forename: Clotilde
authors.initials: C
authors.lastname: Lecrux
authors.affiliation: Department of Medical System Engineering &School of Mechatronics, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.|Department of Neurosurgery, Presbyterian Medical Center, Jeonju, Republic of Korea.
authors.forename: Hyoung-Ihl
authors.initials: HI
authors.lastname: Kim
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging (MCSA), Douglas Mental Health University Institute, Departments of Neurology and Neurosurgery, Psychiatry, and Pharmacology, McGill University, Montreal, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Gauthier
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Luc
authors.initials: L
authors.lastname: Pellerin
authors.affiliation: Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Canada.
authors.forename: Edith
authors.identifier: http://orcid.org/0000-0001-5223-7315
authors.initials: E
authors.lastname: Hamel
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging (MCSA), Douglas Mental Health University Institute, Departments of Neurology and Neurosurgery, Psychiatry, and Pharmacology, McGill University, Montreal, Canada.|McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada.
authors.forename: Pedro
authors.identifier: http://orcid.org/0000-0001-9116-1376
authors.initials: P
authors.lastname: Rosa-Neto
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001692:Biological Transport; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D002443:Ceftriaxone / Q000494:pharmacology; D002478:Cells, Cultured; D027341:Excitatory Amino Acid Transporter 1 / Q000819:agonists / Q000502:physiology*; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D059907:Functional Neuroimaging; D018698:Glutamic Acid / Q000378:metabolism*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D049268:Positron-Emission Tomography; D051381:Rats; D014738:Vibrissae / Q000502:physiology
chemical_list: D027341:Excitatory Amino Acid Transporter 1; D019788:Fluorodeoxyglucose F18; D018698:Glutamic Acid; D002443:Ceftriaxone