title: [Adaptogenic and neuroprotective effects of lithium ascorbate].
abstract: OBJECTIVE
  Investigation of the neuroprotective properties of lithium ascorbate on the stress models in vivo and in vitro.
  
  
  METHODS
  Neurocytological and behavioral studies on nerve cell culture and animal stress models.
  
  
  RESULTS
  Significant neuroprotective effect of lithium ascorbate in neuronal cultures exposed to glutamate toxicity and adaptogenic effect of this drug in stress model in rats were shown.
  
  
  CONCLUSIONS
  The results suggest lithium ascorbate has a high neuroprotective potential in stress models in vivo and in vitro.
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Pronin
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Gromova
authors.affiliation: Moscow Institute of Physics and Technology.
authors.forename: I S
authors.initials: IS
authors.lastname: Sardaryan
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Torshin
authors.affiliation: All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Stel'mashuk
authors.affiliation: St. Petersburg State Pediatric Medical University, St. Petersburg, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Ostrenko
authors.affiliation: All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia.
authors.forename: O P
authors.initials: OP
authors.lastname: Aleksandrova
authors.affiliation: All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Genrikhs
authors.affiliation: All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia.
authors.forename: L G
authors.initials: LG
authors.lastname: Khaspekov
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use; D002478:Cells, Cultured; D004195:Disease Models, Animal; D018698:Glutamic Acid / Q000494:pharmacology; D018020:Lithium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000188:drug therapy*
chemical_list: D018020:Lithium Compounds; D018696:Neuroprotective Agents; D018698:Glutamic Acid; D001205:Ascorbic Acid