title: [Effectiveness of intravenous sedation with midazolam-diphenhydramine in patients who are going to perform an magnetic resonance].
abstract: BACKGROUND
  The requirement of the anesthesiologist for patient care outside the surgical area is constantly increasing. It is an activity that encompasses the different degrees of monitoring, sedation, and anesthesia.
  
  
  OBJECTIVE
  To compare the safety and efficacy of midazolam midazolam-diphenhydramine against magnetic resonance with level of sedation on the Ramsay scale.
  
  
  METHODS
  We performed a study in the Instituto Mexicano del Seguro Social Obregon, Sonora, of patients scheduled for cranial magnetic resonance imaging with sedation, during October and December 2013, comparing two groups: midazolam/diphenhydramine against midazolam groups.
  
  
  RESULTS
  We included 68 patients, 34 in the experimental group (midazolam-diphenhydramine) versus 34 controls (midazolam). The Ramsay scale showed, in the experimental group, an increased sedation effect resulting in one Ramsay 1, at 10 minutes 2.8 2.8 20 minutes and 30 minutes 2.0. In the control group the basal Ramsay was 1, 2.1 to 10 minutes, 20 minutes and 2.1 to 2.0 at 30 minutes (p = 0.0001). The analysis of heart rate, respiratory, and baseline oxygen saturation, at 10, 20 and 30 minutes, was p = 0.0001 for both groups.
  
  
  CONCLUSIONS
  The combination of diphenhydramine with intravenous midazolam is safe, with the degree of sedation being better compared with use of midazolam alone, resulting in less failure of sedation during magnetic resonance imaging.
authors.affiliation: Coordinación clínica de Educación e Investigación en Salud, HGR No. 1, IMSS, Obregón, Son., México.
authors.forename: Lucía
authors.initials: L
authors.lastname: Álvarez-Bastidas
authors.affiliation: Servicio de Medicina del Trabajo, Unidad Médica de Alta Especialidad, IMSS, Obregón, Son., México.
authors.forename: Enrique
authors.initials: E
authors.lastname: Sabag-Ruiz
authors.affiliation: Servicio de Anestesiología, Unidad Médica de Alta Especialidad, IMSS, Obregón, Son., México.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Medina-Soto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016292:Procedural Sedation; D004155:Diphenhydramine / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D004155:Diphenhydramine; D008874:Midazolam