title: The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics.
abstract: The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee and are associated with an increased risk of developing osteoarthritis (OA). While this risk has been largely attributed to loss of the biomechanical functions of the menisci, there is accumulating evidence suggesting that other aspects of meniscal biology may play a role in determining the long-term consequences of meniscal damage for joint health. In this narrative review, we examine the existing literature and present some new data implicating synthesis and secretion of enzymes and other pro-catabolic mediators by injured and degenerate menisci, contributing to the pathological change in other knee joint tissues in OA.
authors.affiliation: a Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern , University of Sydney, Royal North Shore Hospital , St. Leonards , Australia.|b Graduate School of Biomedical Engineering , University of New South Wales , Sydney , Australia.
authors.forename: James
authors.initials: J
authors.lastname: Melrose
authors.affiliation: a Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern , University of Sydney, Royal North Shore Hospital , St. Leonards , Australia.
authors.forename: Emily S
authors.initials: ES
authors.lastname: Fuller
authors.affiliation: a Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern , University of Sydney, Royal North Shore Hospital , St. Leonards , Australia.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Little
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D001696:Biomechanical Phenomena; D019902:Chondrocytes / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D000072600:Meniscus / Q000473:pathology* / Q000503:physiopathology*; D020370:Osteoarthritis, Knee / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*
keywords: Meniscus; osteoarthritis; pathobiology