title: Is There a Link between Human Herpesvirus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study.
abstract: Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Biopsy was obtained from the PR lesion and from the healthy skin of controls for detection of HHV-6 and 7 as well as TLRs 2, 3, 4, 7, 8, and 9 gene expression using real-time polymerase chain reaction (PCR). Significantly elevated expression of all studied TLRs and significantly higher viral load of HHV-6 and 7 in PR cases were detected. A significant higher expression of TLR2 and 4 in HHV-7 positive cases and a significant positive correlation between TLR9 and HHV-7 viral load were documented. HHV6 and 7 may also be involved in the pathogenesis of PR via TLR pathways.
authors.forename: Mostafa Abou
authors.initials: MA
authors.lastname: El-Ela
authors.forename: Eman
authors.initials: E
authors.lastname: Shaarawy
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Komy
authors.forename: Marwa
authors.initials: M
authors.lastname: Fawzy
authors.affiliation: Corresponding author: Rania Abdel Hay, MD, 13th Abrag Othman, Kournish el Maadi, Cairo 11431, Egypt; raniamounir@kasralainy.edu.eg.
authors.forename: Rania Abdel
authors.initials: RA
authors.lastname: Hay
authors.forename: Rehab
authors.initials: R
authors.lastname: Hegazy
authors.forename: Amin
authors.initials: A
authors.lastname: Sharobim
authors.forename: Nadine
authors.initials: N
authors.lastname: Moustafa
authors.forename: Laila
authors.initials: L
authors.lastname: Rashed
authors.forename: Khalda Sayed
authors.initials: KS
authors.lastname: Sayed Amr
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D016199:Herpesvirus 7, Human / Q000302:isolation & purification; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D017515:Pityriasis Rosea / Q000453:epidemiology / Q000276:immunology* / Q000821:virology*; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D012016:Reference Values; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*
chemical_list: D051193:Toll-Like Receptors