title: A Single-Institution Experience in Percutaneous Image-Guided Biopsy of Malignant Pleural Mesothelioma.
abstract: OBJECTIVE
  Mesothelioma has been considered a difficult pathologic diagnosis to achieve via image-guided core needle biopsy. The purpose of this study was to assess the diagnostic sensitivity of percutaneous image-guided biopsy for diagnosis of pleural mesothelioma.
  
  
  METHODS
  Retrospective review was performed to identify patients with a confirmed diagnosis of pleural mesothelioma and who underwent image-guided needle biopsy between January 1, 2002, and January 1, 2016. Thirty-two patients with pleural mesothelioma were identified and included for analysis in 33 image-guided biopsy procedures. Patient, procedural, and pathologic characteristics were recorded. Complications were characterized via standardized nomenclature [Common Terminology for Clinically Adverse Events (CTCAE)].
  
  
  RESULTS
  Percutaneous image-guided biopsy was associated with an overall sensitivity of 81%. No CTCAE clinically significant complications were observed. No image-guided procedures were complicated by pneumothorax or necessitated chest tube placement. No patients had tumor seeding of the biopsy tract.
  
  
  CONCLUSIONS
  Percutaneous image-guided biopsy can achieve high sensitivity for pathologic diagnosis of pleural mesothelioma with a low procedural complication rate, potentially obviating need for surgical biopsy.
authors.affiliation: Department of Radiology, Mayo Clinic, 200 1st ST SW, Rochester, MN, 55905, USA. Welch.brian@mayo.edu.
authors.forename: B T
authors.initials: BT
authors.lastname: Welch
authors.affiliation: Department of Radiology, Mayo Clinic, 200 1st ST SW, Rochester, MN, 55905, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Eiken
authors.affiliation: Department of Radiology, Mayo Clinic, 200 1st ST SW, Rochester, MN, 55905, USA.
authors.forename: T D
authors.initials: TD
authors.lastname: Atwell
authors.affiliation: Department of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st ST SW, Rochester, MN, 55905, USA.
authors.forename: T
authors.initials: T
authors.lastname: Peikert
authors.affiliation: Department of Pathology, Mayo Clinic, 200 1st ST SW, Rochester, MN, 55905, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Yi
authors.affiliation: Department of Thoracic Surgery, Mayo Clinic, 200 1st ST SW, Rochester, MN, 55905, USA.
authors.forename: F
authors.initials: F
authors.lastname: Nichols
authors.affiliation: Department of Radiology, Mayo Clinic, 200 1st ST SW, Rochester, MN, 55905, USA.
authors.forename: G D
authors.initials: GD
authors.lastname: Schmit
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy / Q000295:instrumentation / Q000379:methods*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000473:pathology*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009366:Neoplasm Seeding; D010997:Pleural Neoplasms / Q000473:pathology*; D011030:Pneumothorax / Q000209:etiology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Mesothelioma; Percutaneous image guided biopsy; Thoracic intervention