title: [Treatment Outcome of Anal Squamous Cell Carcinoma Treated with Radical Chemoradiotherapy].
abstract: We reviewed the clinical records of 7 patients with anal squamous cell carcinoma(SCC)to evaluate the effectiveness of radical chemoradiotherapy(CRT). The radiotherapy(RT)consisted of 40 Gy delivered to the pelvis and bilateral inguinal lesions, and a perianal booster dose of 20 Gy, in fractions of 2.0 Gy per day, 5 days per week. 5-fluorouracil(5-FU)and mitomycin C(MMC)were administered 3 times every 4weeks as standard chemotherapy. On the first day of RT, 750mg/m2 of 5-FU in the form of a continuous 24-hour infusion, for 5 days was administered. On the first day of chemotherapy, 10mg/ m2 of MMC was also administered as a single bolus infusion. One patient with a T3 tumor was administered oral TS-1 during RT because of advanced age. In the CRT group, there was 1 case each of T1 and T3, and the others were T2. Grade 2 adverse effects occurred in 5 patients, and Grade 3 in 2, but completion of CRT was achieved in all 7 patients. All patients had a complete response in the anal lesion after CRT. Three patients, including those with the T3 tumor treated with TS-1, developed recurrence of the anal lesion. Two patients with T2 tumors, who were treated with CRT comprising 5-FU and MMC, developed recurrence of the anal lesion more than 60 months after CRT. CRT is expected to be a safe and effective treatment to improve the prognosis for anal squamous carcinoma; however, sufficient and appropriate follow-up is necessary after a complete response.
authors.affiliation: Dept. of Surgery, Fujita Health University.
authors.forename: Harunobu
authors.initials: H
authors.lastname: Sato
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Koide
authors.forename: Miho
authors.initials: M
authors.lastname: Shiota
authors.forename: Zenichi
authors.initials: Z
authors.lastname: Morise
authors.forename: Koutarou
authors.initials: K
authors.lastname: Maeda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Uyama
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome