title: Improvement of hemodynamic performance using novel helical flow vena cava filter design.
abstract: We propose a vena cava filter in which helical flow is created in the filter's working zone to minimize filter blockage by trapped clots and facilitate the lysis of trapped clots. To validate this new design, we compared five helical flow inducers with different thread pitches in terms of blood flow patterns in the filter. The vena cava was reconstructed based on computed tomography images. Both the numerical simulation and in vitro experiment revealed that the helical flow inducer can effectively create a helical flow in the vessel, thereby subduing the filter structure's adverse disruption to blood flow, and increasing flow-induced shear stress in the filter center. In addition, the smaller thread pitch helical flow inducer reduced the oscillating shear index and relative residence time on the vessel wall. Moreover, we observed that the helical flow inducer in the vena cava could induce flow rotation both in clockwise and counterclockwise directions. In conclusion, the new design of the filter with the smaller thread pitch inducer is advantageous over the traditional filter in terms of improving local hemodynamics, which may reduce thrombosis build-up after deployment.
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Deng
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Infection Management and Disease Control, The General Hospital of People's Liberation Army, Beijing, 100853, China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Infection Management and Disease Control, The General Hospital of People's Liberation Army, Beijing, 100853, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Xing
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D003198:Computer Simulation; D004867:Equipment Design; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011655:Pulmonary Embolism / Q000209:etiology / Q000517:prevention & control; D016306:Vena Cava Filters; D014682:Vena Cava, Inferior / Q000503:physiopathology; D020246:Venous Thrombosis / Q000150:complications