title: Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system.
abstract: Sphingolipids are both structural and bioactive compounds. In particular, ceramide and sphingosine 1-phosphate regulate cell fate, inflammation and excitability. 1-α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is known to play an important physiological role in growth and differentiation in a variety of cell types, including neural cells, through genomic actions mediated by its specific receptor, and non-genomic effects that result in the activation of specific signalling pathways. 1,25(OH)2D3and sphingolipids, in particular sphingosine 1-phosphate, share many common effectors, including calcium regulation, growth factors and inflammatory cytokines, but it is still not known whether they can act synergistically. Alterations in the signalling and concentrations of sphingolipids and 1,25(OH)2D3have been found in neurodegenerative diseases and fingolimod, a structural analogue of sphingosine, has been approved for the treatment of multiple sclerosis. This review, after a brief description of the role of sphingolipids and 1,25(OH)2D3, will focus on the potential crosstalk between sphingolipids and 1,25(OH)2D3in neural cells.
authors.affiliation: Department of Biology, University of Pisa, Pisa, Italy.|Interdepartmental Research Center Nutrafood 'Nutraceuticals and Food for Health', University of Pisa, Pisa, Italy.
authors.forename: Mercedes
authors.identifier: 0000-0002-1344-2786
authors.initials: M
authors.lastname: Garcia-Gil
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Molecular and Applied Biology Research Unit, University of Florence, Florence, Italy.|Interuniversitary Miology Institutes, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Pierucci
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Molecular and Applied Biology Research Unit, University of Florence, Florence, Italy.|Interuniversitary Miology Institutes, Italy.
authors.forename: Ambra
authors.initials: A
authors.lastname: Vestri
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Molecular and Applied Biology Research Unit, University of Florence, Florence, Italy.|Interuniversitary Miology Institutes, Italy.
authors.forename: Elisabetta
authors.identifier: 0000-0002-5820-7800
authors.initials: E
authors.lastname: Meacci
mesh_terms: D000818:Animals; D002762:Cholecalciferol / Q000378:metabolism*; D006801:Humans; D009420:Nervous System / Q000378:metabolism*; D013107:Sphingolipids / Q000378:metabolism*
chemical_list: D013107:Sphingolipids; D002762:Cholecalciferol