title: Relation between serum leptin levels, lipid profiles and neurocognitive deficits in Chinese OSAHS patients.
abstract: OBJECTIVE
  The aim of this study was to compare serum leptin, apolipoprotein A1 (ApoA1), apolipoprotein J (ApoJ) and apolipoprotein H (ApoH) levels in males with obstructive sleep apnea and hypopnea syndrome (OSAHS) to those in healthy control subjects and to examine the possible relation between neurocognitive performance and these factors/serum markers in the subjects.
  
  
  METHODS
  In this observational, cross-sectional study, a full-night polysomnography and sensitive neuropsychological assessment were performed on 50 newly diagnosed Chinese male patients and 30 healthy subjects. Fasting blood samples were used to measure leptin and ApoA1, ApoH and ApoJ levels using ELISA.
  
  
  RESULTS
  Compared with normal control subjects, OSAHS patients have significantly lower levels of ApoA1 and higher levels of leptin, ApoH and ApoJ. After adjustment for age, years of education, body mass index (BMI) and apnea-hypopnea index, leptin and ApoA1 were associated with global cognitive function, and leptin level was positively correlated with inhibition reaction time. ApoJ was negatively correlated with visual reproduction and logical memory performance. Multiple regression analysis shows that from age, BMI, education year, biomarker levels and the parameters of PSG, only the variables of leptin and education year added to the prediction of the Montreal cognitive assessment score in a statistically significant way.
  
  
  CONCLUSIONS
  Abnormal expression of leptin and apolipoproteins and poor performance on neuropsychological tests were observed in patients with OSAHS. There is also an association between serum leptin, ApoA1, and ApoJ levels and cognitive performance in the patients.
authors.affiliation: a Department of Respiratory Medicine , Respiratory Disease Research Institute, The Second Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Yating
authors.identifier: http://orcid.org/0000-0003-2345-4059
authors.initials: Y
authors.lastname: Peng
authors.affiliation: a Department of Respiratory Medicine , Respiratory Disease Research Institute, The Second Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: b Mental Health Institute, The Second Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Cao
authors.affiliation: a Department of Respiratory Medicine , Respiratory Disease Research Institute, The Second Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: a Department of Respiratory Medicine , Respiratory Disease Research Institute, The Second Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Department of Respiratory Medicine , Respiratory Disease Research Institute, The Second Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zong
authors.affiliation: a Department of Respiratory Medicine , Respiratory Disease Research Institute, The Second Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Ruoyun
authors.identifier: http://orcid.org/0000-0001-5374-3455
authors.initials: R
authors.lastname: Ouyang
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001053:Apolipoproteins / Q000097:blood*; D002681:China; D060825:Cognitive Dysfunction / Q000209:etiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications* / Q000503:physiopathology
chemical_list: D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D020738:Leptin
keywords: Neurocognition; biomarkers; sleep disorders