title: Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice.
abstract: This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan. M16T4009Y@edu.tottori-u.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Koizumi
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan. kazu-azuma@muses.tottori-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan. h-izawa@chem.tottori-u.ac.jp.
authors.forename: Hironori
authors.initials: H
authors.lastname: Izawa
authors.affiliation: Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan. morimoto@chem.tottori-u.ac.jp.
authors.forename: Minoru
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan. kosukeochi28@gmail.com.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ochi
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan. tsuka@muses.tottori-u.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan. imagawat@muses.tottori-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imagawa
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan. tosaki@muses.tottori-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan. taro@muses.tottori-u.ac.jp.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ito
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan. yokamoto@muses.tottori-u.ac.jp.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan. saimoto@chem.tottori-u.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saimoto
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan. sifuku@chem.tottori-u.ac.jp.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ifuku
mesh_terms: D000107:Acetylation; D000284:Administration, Oral; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D002686:Chitin / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D048271:Chitosan / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D019394:Ki-67 Antigen / Q000378:metabolism; D008810:Mice, Inbred C57BL; D052016:Mucositis / Q000139:chemically induced* / Q000188:drug therapy*; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009195:Peroxidase / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D002686:Chitin; D048271:Chitosan; D009195:Peroxidase; D053148:Caspase 3; D005472:Fluorouracil
keywords: 5-fluorouracil; apoptosis; chitosan; mucositis; surface deacetylated chitin nanofiber