title: Matrix metalloproteinase-1 promoter -1607 bp 1G/2G polymorphism associated with increased risk of spinal tuberculosis in Southern Chinese Han population.
abstract: BACKGROUND
  Spinal tuberculosis is the most common form of musculoskeletal tuberculosis. The expression of matrix metalloproteinase-1 (MMP-1) is increased in cells with Mycobacterium tuberculosis infection. MMP-1 plays a curial role in extracellular matrix degradation during the progression of tuberculosis. Although the 1G/2G polymorphism in MMP-1-1607 influences its transcription, its role in spinal tuberculosis remains unknown.
  
  
  METHODS
  Healthy controls and patients with spinal tuberculosis of Han ethnicity were recruited between January 2010 and May 2016. The MMP-1-1607 1G/2G polymorphism was genotyped using the Sequenom mass Array polymorphism analysis system.
  
  
  RESULTS
  The genotypes of 1G/1G, 1G/2G, and 2G/2G were found in 13.7%, 53.6%, and 32.8% of patients, and 12.2%, 37.4%, and 50.4% of controls, respectively. The 1G/2G genotype were more common in cases than in controls (P=2.05E-04). The 1G allele showed an association with an increased risk for spinal tuberculosis when compared to 2G allele (P=.004). 1G genotypes, having at least one 1G allele, were associated with the risk of developing spinal tuberculosis (1G/1G+1G/2G vs 2G/2G: OR=2.084, 95%CI=1.401-3.100, P=2.65E-04).
  
  
  CONCLUSIONS
  1G genotypes of the MMP-1-1607 may be associated with susceptibility to spinal tuberculosis in Southern Chinese Han population.
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Guangxi Autonomous Region, Nanning, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Qile
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of Neurology, The First Hospital of Changsha, Changsha, China.
authors.forename: Dan
authors.initials: D
authors.lastname: He
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ang
authors.initials: A
authors.lastname: Deng
authors.affiliation: Department of Clinical Laboratory, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.
authors.forename: Rongfu
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Guangxi Autonomous Region, Nanning, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Tan
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Guo
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Longjie
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Guanteng
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D012307:Risk Factors; D014399:Tuberculosis, Spinal / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult
chemical_list: C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
keywords: Southern Chinese Han population; matrix metalloproteinase-1; polymorphism; spinal tuberculosis