title: Long Blood Residence and Large Tumor Uptake of Ruthenium Sulfide Nanoclusters for Highly Efficient Cancer Photothermal Therapy.
abstract: Transition metal sulfide (TMS) holds great potential in cancer photothermal therapy (PTT) because of the high absorbance in the near-infrared (NIR) region. The short blood circulation time and limited tumor accumulation of TMS-based photothermal agents, however, limit their applications. Herein, we design a novel TMS-based PTT agent, ruthenium sulfide-based nanoclusters (NCs), to overcome the current limitations. We firstly develop a simple method to prepare oleic acid coated ruthenium sulfide nanodots (OA-RuS1.7NDs) and assemble them into water-soluble NCs via sequentially coating with denatured bovine serum albumin (dBSA) and poly(ethylene glycol) (PEG). The obtained PEG-dBSA-RuS1.7NCs possess excellent photothermal conversion ability. More significantly, they exhibit enhanced blood circulation time and tumor-targeting efficiency in vivo compared with other TMS-based PTT nanoagents, which may be attributed to their appropriate hydrodynamic diameter (~70 nm) and an ideal charge (~0 mV). These characteristics help the PEG-dBSA-RuS1.7NCs to escape the removal by the reticuloendothelial system (RES) and kidney. All these advantages enable the PEG-dBSA-RuS1.7NCs to selectively concentrate in tumor sites and effectively ablate the cancer cells upon NIR irradiation.
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education, Hainan Medical College, Haikou 571101, China.
authors.forename: Zhuoxuan
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education, Hainan Medical College, Haikou 571101, China.
authors.forename: Feng-Ying
authors.initials: FY
authors.lastname: Huang
authors.affiliation: Department of Chemical Engineering, Monash University, Wellington Rd., Clayton, Vic 3800, Australia.
authors.forename: Rong
authors.initials: R
authors.lastname: Cao
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education, Hainan Medical College, Haikou 571101, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education, Hainan Medical College, Haikou 571101, China.
authors.forename: Guang-Hong
authors.initials: GH
authors.lastname: Tan
authors.affiliation: Hunan Key Laboratory of Green Chemistry and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412008, China.
authors.forename: Nongyue
authors.initials: N
authors.lastname: He
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, Suzhou 215123, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.affiliation: College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China.
authors.forename: Guizhen
authors.initials: G
authors.lastname: Wang
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, Suzhou 215123, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D004195:Disease Models, Animal; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: D011092:Polyethylene Glycols; D012428:Ruthenium