title: Dendrosomal nanocurcumin prevents morphine self-administration behavior in rats despite CA1 damage.
abstract: Dendrosomal nanocurcumin (DNC) is fabricated from esterification of oleic acid and polyethylene glycol residues with curcumin. DNC has shown antioxidant, neuroprotective, and neurogenesis-enhancing effects. In addition, it can attenuate morphine tolerance. Morphine self-administration is associated with neurodegenerative changes of CA1 neurons in the adult hippocampus. The present study evaluated the effect of DNC pretreatment on morphine self-administration and hippocampal damage. Rats were pretreated with DNC (5 and 10 mg/kg, intraperitoneally) 30 min before a morphine self-administration paradigm performed in 2-h/sessions for 12 days under a FR-1 schedule. Pretreatment with both doses of DNC markedly suppressed morphine intake. Morphine self-administration resulted in a 71% reduction in the number of hippocampal CA1 neurons. DNC (5 mg/kg) pretreatment only marginally improved (by 22%) neuronal loss in this area. The data suggest that the effect of DNC on morphine self-administration is largely independent of the CA1 area. A functional restoration and regulation of reward circuit activity by DNC may reduce the motivation for morphine despite CA1 damage.
authors.affiliation: aDepartment of Biology, Basic Sciences School, Shahed University, Tehran bDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Jalaleden
authors.initials: J
authors.lastname: Noroozi
authors.forename: Majid
authors.initials: M
authors.lastname: Hassanpour-Ezatti
authors.forename: Hojjat A
authors.initials: HA
authors.lastname: Alaei
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000473:pathology; D002408:Catheters, Indwelling; D002452:Cell Count; D002491:Central Nervous System Agents / Q000008:administration & dosage*; D003474:Curcumin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D008297:Male; D009020:Morphine / Q000008:administration & dosage; D009021:Morphine Dependence / Q000473:pathology / Q000517:prevention & control*; D009294:Narcotics / Q000008:administration & dosage; D019636:Neurodegenerative Diseases / Q000139:chemically induced / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D011897:Random Allocation; D017208:Rats, Wistar; D012646:Self Administration
chemical_list: D002491:Central Nervous System Agents; D009294:Narcotics; D009020:Morphine; D003474:Curcumin