title: MiR-222 in Cardiovascular Diseases: Physiology and Pathology.
abstract: MicroRNAs (miRNAs and miRs) are endogenous 19-22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests that deregulated miRNAs play an important role in the genesis of cardiovascular diseases. Additionally, circulating miRNAs can be biomarkers for cardiovascular diseases. MiR-222 has been reported to play important roles in a variety of physiological and pathological processes in the heart. Here we reviewed the recent studies about the roles of miR-222 in cardiovascular diseases. MiR-222 may be a potential cardiovascular biomarker and a new therapeutic target in cardiovascular diseases.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Shengguang
authors.initials: S
authors.lastname: Ding
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.
authors.forename: Chongjun
authors.identifier: 0000-0002-3651-4906
authors.initials: C
authors.lastname: Zhong
mesh_terms: D001808:Blood Vessels / Q000473:pathology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005819:Genetic Markers / Q000502:physiology; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology*; D008955:Models, Cardiovascular; D009206:Myocardium / Q000473:pathology; D012727:Sex Characteristics
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs; C525710:MIR222, human