title: 3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS profile/view ordering: Feasibility of right ventricular myocardial damage assessment using a swine animal model.
abstract: To develop a high-resolution, 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (MRI) technique for improved assessment of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE MRI using a surgically implanted animal scar model in the right ventricle (RV).
  
  
  
  A k-space segmented 3D LGE acquisition using CENTRA-PLUS (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal Signal; or CP) ordering is proposed. 8 pigs were surgically prepared with cardiac patch implantation in the RV, followed in 60days by 1.5T MRI. LGE with Phase-Sensitive Inversion Recovery (PSIR) were performed as follows: 1) 2DBH using pneumatic control, and 2) navigator-gated, 3D free-breathing (3DFB)-CP-LGE with slice-tracking. The animal heart was excised immediately after cardiac MR for scar volume quantification. RV scar volumes were also delineated from the 2DBH and 3DFB-CP-LGE images for comparison against the surgical standard. Apparent scar/normal tissue signal-to-noise ratio (aSNR) and contrast-to-noise ratio (aCNR) were also calculated. 3DFB-CP-LGE technique was successfully performed in all animals. No difference in aCNR was noted, but aSNR was significantly higher using the 3D technique (p<0.05). Against the surgical reference volume, the 3DFB-CP-LGE-derived delineation yielded significantly less volume quantification error compared to 2DBH-derived volumes (15±10% vs 55±33%; p<0.05).
  
  
  
  Compared to conventional 2DBH-LGE, 3DFB-LGE acquisition using CENTRA-PLUS provided superior scar volume quantification and improved aSNR.
authors.affiliation: Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States. Electronic address: kkawaji@medicine.bsd.uchicago.edu.
authors.forename: Keigo
authors.initials: K
authors.lastname: Kawaji
authors.affiliation: Department of Radiology, The University of Chicago, Chicago, IL, United States.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States.
authors.forename: Mita B
authors.initials: MB
authors.lastname: Patel
authors.affiliation: Philips, Gainesville, FL, United States.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States.
authors.forename: Francesco
authors.initials: F
authors.lastname: Maffessanti
authors.affiliation: Department of Radiology, The University of Chicago, Chicago, IL, United States.
authors.forename: Takeyoshi
authors.initials: T
authors.lastname: Ota
authors.affiliation: Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States; Department of Surgery, Section of Cardiothoracic Surgery, The University of Chicago, Chicago, IL, United States.
authors.forename: Amit R
authors.initials: AR
authors.lastname: Patel
mesh_terms: D000818:Animals; D062485:Breath Holding; D003287:Contrast Media; D004195:Disease Models, Animal; D005260:Female; D005682:Gadolinium; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009203:Myocardial Infarction / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D012119:Respiration; D059629:Signal-To-Noise Ratio; D013552:Swine
chemical_list: D003287:Contrast Media; D005682:Gadolinium
keywords: Breath-hold; Late gadolinium enhancement MRI; Myocardial infarction; Navigator; Viability imaging