title: Identifying Cardiovascular Risk in Survivors of Childhood Leukaemia Treated with Haematopoietic Stem Cell Transplantation and Total Body Irradiation .
abstract: BACKGROUND
  Survivors of childhood with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have an increased cardiometabolic risk without overt obesity.
  
  
  OBJECTIVE
  To describe cardiometabolic risk in HSCT/TBI survivors and identify anthropometric measurements of adiposity representative of cardiometabolic risks in HSCT/TBI survivors.
  
  
  METHODS
  Childhood leukaemia survivors treated with HSCT/TBI (n = 21, 11 males) were compared with chemotherapy-only (n = 31) and obese non-leukaemic controls (n = 30). All subjects (16-26 years) had blood pressure and auxological measurements (body mass index, waist and hip circumferences) and blood tests (triglycerides, high-density lipoprotein [HDL], and oral glucose tolerance tests). Central adiposity was defined as either increased waist circumference (WC), waist-to-height ratio (WHtR) (>0.5), or waist-to-hip ratio (WHR) (males >0.9, females >0.85).
  
  
  RESULTS
  HSCT/TBI survivors showed higher prevalence of hypertriglyceridaemia than both comparison groups and higher prevalence of reduced HDL compared to the chemotherapy-only group. The WHR reported a higher prevalence of increased adiposity in HSCT/TBI survivors compared with WC and WHtR, but such differences were not observed in the other groups. In the HSCT survivors, WHR had the highest number of significant associations with metabolic risk factors, and metabolic risks worsen with time elapsed since primary treatment.
  
  
  CONCLUSIONS
  HSCT/TBI survivors have high cardiometabolic risk that is not sufficiently reflected by WC alone. WHR is a useful surrogate marker for increased cardiometabolic risk in HSCT/TBI survivors. .
authors.forename: Christina
authors.initials: C
authors.lastname: Wei
authors.forename: Linda
authors.initials: L
authors.lastname: Hunt
authors.forename: Rachel
authors.initials: R
authors.lastname: Cox
authors.forename: Karin
authors.initials: K
authors.lastname: Bradley
authors.forename: Ruth
authors.initials: R
authors.lastname: Elson
authors.forename: Julian
authors.initials: J
authors.lastname: Shield
authors.forename: Michael
authors.initials: M
authors.lastname: Stevens
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Crowne
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000328:Adult; D064591:Allografts; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D017741:Survivors; D014280:Triglycerides / Q000097:blood; D014916:Whole-Body Irradiation
chemical_list: D008075:Lipoproteins, HDL; D014280:Triglycerides