title: The association between HDAC9 gene polymorphisms and stroke risk in the Chinese population: A meta-analysis.
abstract: Several recent genome-wide association studies (GWASs) have suggested that the histone deacetylase 9 (HDAC9) gene is associated with stroke, but the reliability of these findings remains controversial, particularly for the data derived from different ethnicities and geographical locations. Therefore, we performed a meta-analysis to explore the associations between HDAC9 polymorphisms and the risk of stroke in the Chinese population. All eligible case-control studies that met the search criteria were retrieved from multiple databases, and six case-control studies with a total of 2,356 stroke patients and 3,420 healthy controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations of 3 HDAC9 gene polymorphisms with stroke risk. Our results revealed statistically significant associations of the rs2107595 (T/C) polymorphism with an increased risk of stroke in the allele, codominant and dominant models. Additionally, the rs2389995 (G/A) polymorphism was found to be significantly associated with a decreased risk of stroke in all genetic models. In conclusion, this meta-analysis suggested that the T allele of rs2107595 in HDAC9 increases the risk of stroke but that the G allele of rs2389995 decreases the risk of stroke in the Chinese population.
authors.affiliation: Institute of Immunology, College of Life Science and Technology, Jinan University, Guangdong 510630, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
authors.forename: Tangming
authors.initials: T
authors.lastname: Guan
authors.affiliation: Institute of Immunology, College of Life Science and Technology, Jinan University, Guangdong 510630, China.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Li
authors.affiliation: Institute of Immunology, College of Life Science and Technology, Jinan University, Guangdong 510630, China.
authors.forename: Zinan
authors.initials: Z
authors.lastname: Jiao
authors.affiliation: Institute of Immunology, College of Life Science and Technology, Jinan University, Guangdong 510630, China.
authors.forename: Xiaoshuang
authors.initials: X
authors.lastname: Lu
authors.affiliation: Institute of Immunology, College of Life Science and Technology, Jinan University, Guangdong 510630, China.
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Institute of Immunology, College of Life Science and Technology, Jinan University, Guangdong 510630, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226002, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Ji
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D017594:Publication Bias; D012097:Repressor Proteins / Q000235:genetics*; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*
chemical_list: D012097:Repressor Proteins; C486544:HDAC9 protein, human; D006655:Histone Deacetylases