title: The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP.
abstract: Long non-coding RNA (lncRNA) urothelial carcinoma associated 1 (UCA1) has been reported to be involved in the development and progression of many types of tumors including breast cancer, gastric cancer, and bladder cancer. However, the exact effects and molecular mechanisms of UCA1 in glioma progression remain unclear up to now. In this study, we firstly found that UCA1 was upregulated in glioma tumor samples and negatively correlated with survival time. Then, we investigated the role of UCA1 in human glioma cell lines. Our results showed that upregulation of lncRNA-UCA1 in glioma tissues and cell lines could promote glioma cell proliferation and migration through interaction with miR-182, and knockdown of UCA1 inhibited the proliferation and migration of human glioma cell. In addition, miR-182 dependent inhibitor of apoptosis-stimulating protein of p53 (iASPP) was required in the regulation of UCA1 induced glioma cell proliferation. Taken together, UCA1 might promote proliferation and migration of glioma, to regulate the tumor growth and metastasis via miR-182 dependent iASPP regulation. Therefore, lncRNA-UCA1 could be regarded as a therapeutic target in human glioma.
authors.affiliation: Department of Neurosurgery, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province 610072, China.
authors.forename: Zongze
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Neurosurgery, Kai Luan General Hospital, Tangshan City, Hebei Province 063000, China.
authors.forename: Yujue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province 610072, China.
authors.forename: Guangfu
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province 610072, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province 610072, China. Electronic address: zhaodongd1980@qq.com.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province 610072, China. Electronic address: chenly11@163.com.
authors.forename: Longyi
authors.initials: L
authors.lastname: Chen
mesh_terms: D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D062085:RNA, Long Noncoding / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D035683:MicroRNAs; C538984:Mirn182 microRNA, human; C119612:PPP1R13L protein, human; D062085:RNA, Long Noncoding; D012097:Repressor Proteins; C515159:UCA1 RNA, human
keywords: Glioma; Long non-coding RNA; MiR-182; Migration; Proliferation; iASPP