title: Predictive factors for survival in neoadjuvant radiochemotherapy for advanced rectal cancer.
abstract: BACKGROUND
  Neoadjuvant radiochemotherapy followed by radical surgery is the standard approach in advanced rectal carcinoma. Tumor response is determined in histological specimen.
  
  
  OBJECTIVE
  To assess predictive factors for survival in 115 patients.
  
  
  METHODS
  115 patients treated with neoadjuvant radiochemotherapy followed by radical surgery with total mesorectal excision, in our hospital from January 2007 to December 2014. All patients received pelvic radiotherapy with concomitant chemotherapy, followed by radical surgery and in some adjuvant chemotherapy.
  
  
  RESULTS
  In univariate analysis, distance to anal verge, radial margin, perineural invasion, and good grade regression are predictive factors for both, specific and disease free survival; and in multivariant, only radial margin and perineural invasion were predictive factors for survival. We found distance to anal verge (<5 cm) as the only clinical factor to predict a positive margin in the histologic specimen.
  
  
  CONCLUSIONS
  Perineural invasion and positive radial margin are predictive factors for both specific and disease free survival.
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain. areig@parcdesalutmar.cat.
authors.forename: A
authors.identifier: http://orcid.org/0000-0003-3691-9679
authors.initials: A
authors.lastname: Reig Castillejo
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Membrive
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Foro
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Quera
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Sanz
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Rodriguez
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fernández-Velilla
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Pera
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Ortiz
authors.affiliation: Department of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Algara
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059186:Chemoradiotherapy, Adjuvant / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000401:mortality*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Overall survival; Predictive factors; Radiochemotherapy; Rectal carcinoma