title: Placental Growth Factor and Vascular Endothelial Growth Factor Together Regulate Tumour Progression via Increased Vasculature in Cutaneous T-cell Lymphoma.
abstract: Angiogenesis is regarded as an essential step in supporting tumour growth and metastasis. In haematological malignancies, including cutaneous T-cell lymphoma (CTCL), angiogenesis is increased and serum levels of some pro-angiogenic markers are elevated. The aim of this study was to investigate expression levels of placental growth factor (PlGF) and vascular endothelial growth factor (VEGF)-A in lesional skin and sera in patients with CTCL, and to assess the association of these factors with development of CTCL. A further aim was to investigate the effect of PlGF on lymphoma cell growth in vivo using a tumour inoculation model. Expression of PlGF and VEGF-A were significantly elevated in CTCL skin. Tumour cells expressed PlGF in some cases. Serum PlGF levels were increased in patients with advanced CTCL and correlated with disease markers. Moreover, PlGF enhanced lymphoma cell growth in vivo through increasing tumour vasculature. These findings suggest that angiogenesis plays a role in the progression of CTCL and raises the possibility of using inhibitors of PlGF in CTCL therapy.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. miyagakit-der@h.u-tokyo.ac.jp, asahikari1979@gmail.com.
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Miyagaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Tomonori
authors.initials: T
authors.lastname: Oka
authors.forename: Naomi
authors.initials: N
authors.lastname: Takahashi
authors.forename: Makiko
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Hiraku
authors.initials: H
authors.lastname: Suga
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujita
authors.forename: Ayumi
authors.initials: A
authors.lastname: Yoshizaki
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008810:Mice, Inbred C57BL; D009182:Mycosis Fungoides / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic; D000072483:Placenta Growth Factor / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012751:Sezary Syndrome / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors; D047368:Tumor Burden; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
chemical_list: C000608036:PGF protein, human; C000608037:Pgf protein, mouse; D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D000072483:Placenta Growth Factor