title: Electrophysiological basis of reading related phonological impairment in Chinese speakers with schizophrenia: An ERP study.
abstract: It has been reported in alphabetic languages that individuals with schizophrenia showed language-related cognitive impairments including phonological deficits, which were in turn associated with clinical symptoms such as auditory hallucinations and thought disorders. To date, however, the phonological deficits involved in schizophrenia in Chinese and its neural basis have not been well established. In order to establish such a relationship we conducted a behavioral study using lexical tone judgment and digit span tasks as well as an event-related potential (ERP) study with an auditory oddball paradigm, in particular, for P300 effects, the event-related brain potential (ERP) index of discrimination. Chinese patients with schizophrenia and Chinese healthy controls in China participated in the current study. Compared to the healthy controls, the patients with schizophrenia showed significant impairments in phonological processing skills, which in turn significantly correlated with smaller P300 effects. Thus these behavioral and electrophysiological findings in Chinese patients with schizophrenia were critically evaluated in terms of their phonological processing abilities.
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Jiuju
authors.initials: J
authors.lastname: Wang
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Centre for Cognition and Neuroimaging, Brunel University London, Uxbridge, UK.
authors.forename: Taeko N
authors.initials: TN
authors.lastname: Wydell
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Jinmin
authors.initials: J
authors.lastname: Liao
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Quan
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Ju
authors.initials: J
authors.lastname: Tian
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China. Electronic address: dongwentian@bjmu.edu.cn.
authors.forename: Wentian
authors.initials: W
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000328:Adult; D001184:Articulation Disorders / Q000150:complications / Q000503:physiopathology; D044466:Asian People; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002681:China; D004410:Dyslexia / Q000150:complications / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006212:Hallucinations / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D011932:Reading; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult
keywords: Lexical tone; Neural basis; P300 effects; Phonological processing abilities; Schizophrenia