title: Correlates of Physical Functioning and Performance Across the Spectrum of Kidney Function.
abstract: The aim of this study was to determine the extent to which poor physical functioning, low participation in physical activity, and muscle atrophy observed among patients on hemodialysis are evident in the earlier stages of chronic kidney disease (CKD). We enrolled adults in three groups: no CKD, Stages 3 to 4 CKD, and hemodialysis. Outcomes measured were physical activity, muscle size, thigh muscle strength, physical performance, and self-reported physical function. Patients with CKD had muscle area intermediate between the no CKD and hemodialysis groups, but they had low levels of physical activity that were similar to the hemodialysis group. Physical activity and muscle size were significantly associated with all outcomes. Kidney function was not significantly associated with muscle strength or physical performance after adjustment for physical activity and muscle size. In conclusion, interventions aimed to increase muscle mass and energy expenditure might have an impact on improving physical function of CKD patients.
authors.affiliation: 1 Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Segura-Ortí
authors.affiliation: 2 University of California, San Francisco, CA, USA.
authors.forename: P L
authors.initials: PL
authors.lastname: Gordon
authors.affiliation: 3 Northern California Institute for Research and Education, San Francisco, CA, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Doyle
authors.affiliation: 2 University of California, San Francisco, CA, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Johansen
mesh_terms: D061725:Accelerometry; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D011788:Quality of Life; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*; D057566:Self Report
keywords: chronic kidney disease; health-related quality of life; hemodialysis; physical activity