title: Cytotoxic Compounds Derived from Marine Sponges. A Review (2010-2012).
abstract: Abstract: This extensive review covers research published between 2010 and 2012 regarding new compounds derived from marine sponges, including 62 species from 60 genera belonging to 33 families and 13 orders of the Demospongia class (Porifera). The emphasis is on the cytotoxic activity that bioactive metabolites from sponges may have on cancer cell lines. At least 197 novel chemical structures from 337 compounds isolated have been found to support this work. Details on the source and taxonomy of the sponges, their geographical occurrence, and a range of chemical structures are presented. The compounds discovered from the reviewed marine sponges fall into mainly four chemical classes: terpenoids (41.9%), alkaloids (26.2%), macrolides (8.9%) and peptides (6.3%) which, along with polyketides, sterols, and others show a range of biological activities. The key sponge orders studied in the reviewed research were Dictyoceratida, Haplosclerida, Tetractinellida, Poecilosclerida, and Agelasida.Petrosia,Haliclona(Haplosclerida),Rhabdastrella(Tetractinellida),CoscinodermaandHyppospongia(Dictyioceratida), were found to be the most promising genera because of their capacity for producing new bioactive compounds. Several of the new compounds and their synthetic analogues have shown in vitro cytotoxic and pro-apoptotic activities against various tumor/cancer cell lines, and some of them will undergo further in vivo evaluation.
authors.affiliation: Laboratory of Enzymology - LABENZ, Department of Biochemistry, Federal University of Pernambuco, Recife 50670-901, Pernambuco, Brazil. robertomioso@yahoo.co.uk.
authors.forename: Roberto
authors.initials: R
authors.lastname: Mioso
authors.affiliation: Department of Chemistry, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria 35017, Spain. ftoledo@dqui.ulpgc.es.
authors.forename: Francisco J Toledo
authors.initials: FJ
authors.lastname: Marante
authors.affiliation: Laboratory of Enzymology - LABENZ, Department of Biochemistry, Federal University of Pernambuco, Recife 50670-901, Pernambuco, Brazil. ransoube@uol.com.br.
authors.forename: Ranilson de Souza
authors.initials: RS
authors.lastname: Bezerra
authors.affiliation: Post-Graduation Program in Natural Products and Synthetic Bioactives, Federal University of Paraíba, João Pessoa 58051-970, Paraíba, Brazil. flavinhovb@hotmail.com.
authors.forename: Flávio Valadares Pereira
authors.initials: FV
authors.lastname: Borges
authors.affiliation: Post-Graduation Program in Development and Technological Innovation in Medicines, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil. barbara@ltf.ufpb.br.
authors.forename: Bárbara V de Oliveira
authors.initials: BV
authors.lastname: Santos
authors.affiliation: Department of Biology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria 35017, Spain. irma.herrera102@alu.ulpgc.es.
authors.forename: Irma Herrera Bravo de
authors.initials: IH
authors.lastname: Laguna
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D011161:Porifera / Q000737:chemistry* / Q000145:classification
chemical_list: D001688:Biological Products
keywords: Keywords: porifera; bioactive molecules; cancer cell lines; cytotoxicity; marine sponges; pharmacology