title: Interactions between single nucleotide polymorphism ofSERPINA1gene and smoking in association with COPD: a case-control study.
abstract: BACKGROUND
  SERPINA1gene has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), while smoking is a known risk factor for COPD. Little is known on the effect ofSERPINA1gene and its interaction with smoking in the Chinese population. In this study, the effect ofSERPINA1gene polymorphisms on COPD risk and its interaction with smoking status has been investigated.
  
  
  METHODS
  A total of 120 COPD patients and 481 healthy controls were recruited at The Armed Police Corps Hospital. Data on demographic variables, smoking status, history of occupational dust exposure, and allergies were collected. Genotyping for single nucleotide polymorphism's (SNP) rs1243160, rs2854254, and rs8004738 was performed in all participants.
  
  
  RESULTS
  SNP rs8004738 genotype was associated with a significantly higher risk for COPD (odds ratio (OR) =1.835, 95% confidence interval (CI): 1.002-3.360), whereas SNPs rs1243160 and rs2854254 did not exhibit such an association. Smoking habit also significantly increased the risk for COPD (OR =2.306, 95% CI: 1.537-3.459). On stepwise logistic regression analysis, advanced age, smoking, and SNP rs8004738 variant were associated with increased risk for COPD, while female gender and higher educational status decreased the risk. On additive interaction analysis, a significant interactive effect of SNP rs8004738 and smoking was observed in this population (relative excess risk due to interaction =0.478; attributable proportion due to interaction (AP) =0.123; S=1.197).
  
  
  CONCLUSIONS
  SNP rs8004738 ofSERPINA1gene significantly interacted with smoking status and was associated with a higher risk for COPD in the Chinese population.
authors.affiliation: Health Medical Center.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Deng
authors.affiliation: Health Medical Center.
authors.forename: Cun-Hua
authors.initials: CH
authors.lastname: Yuan
authors.affiliation: Department of Respiratory Medicine, General Hospital of Chinese People's Armed Police Forces, Beijing, People's Republic of China.
authors.forename: De
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D016495:Police; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: C043392:SERPINA1 protein, human; D000515:alpha 1-Antitrypsin
keywords: SERPINA1 polymorphism; chronic obstructive pulmonary disease (COPD); single nucleotide polymorphism (SNP); smoking