title: Human Papillomavirus Positivity in the Anal Canal in HIV-Infected and HIV-Uninfected Men Who Have Anal Sex with Men in Guangzhou, China: Implication for Anal Exams and Early Vaccination.
abstract: Background.The epidemiology of HPV in men who have sex with men (MSM) in Guangzhou, China, had not been reported previously.Methods. HIV-infected and HIV-uninfected MSM were recruited from a Guangzhou-based MSM clinic in 2013. Sociodemographic characteristics and sexual behaviors were collected. An anal cytological sample was taken for HPV testing.Results.We recruited 79 HIV-infected and 85 HIV-uninfected MSM. The median age was 26 years in both groups. The positivities of anal HPV of any type (81.0% versus 48.2%), any high risk type (50.6% versus 27.1%), any low risk type (55.7% versus 31.8%), and any 9-valent vaccine type (74.7% versus 36.5%) were all significantly higher among HIV-infected compared to that among HIV-negative MSM (pfor all < 0.05). The great majority of HPV-infected MSM were infected with 9-valent vaccine types (59 out of 64 HIV-infected and 31 out of 41 HIV-uninfected). Anal bacterial infections were associated with higher anal HPV positivity and greater number of anal HPV types.Conclusion.Sexually active MSM in Guangzhou, especially those infected with HIV, had high and multiple HPV detections. The majority of these cases were potentially preventable by HPV vaccine. Regular anal exams and early HPV vaccination are warranted in this population.
authors.affiliation: Guangdong Provincial Center for Skin Disease & STI Control, Guangzhou, Guangdong 510091, China.
authors.forename: Xuqi
authors.initials: X
authors.lastname: Ren
authors.affiliation: Guangdong Provincial Center for Skin Disease & STI Control, Guangzhou, Guangdong 510091, China.
authors.forename: Wujian
authors.initials: W
authors.lastname: Ke
authors.affiliation: Guangdong Provincial Center for Skin Disease & STI Control, Guangzhou, Guangdong 510091, China.
authors.forename: Heping
authors.identifier: 0000-0002-9846-975X
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Guangdong Provincial Center for Skin Disease & STI Control, Guangzhou, Guangdong 510091, China.
authors.forename: Ligang
authors.initials: L
authors.lastname: Yang
authors.affiliation: Guangdong Provincial Center for Skin Disease & STI Control, Guangzhou, Guangdong 510091, China.
authors.forename: Shujie
authors.initials: S
authors.lastname: Huang
authors.affiliation: Guangdong Provincial Center for Skin Disease & STI Control, Guangzhou, Guangdong 510091, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Qin
authors.affiliation: Guangdong Provincial Center for Skin Disease & STI Control, Guangzhou, Guangdong 510091, China.
authors.forename: Bin
authors.identifier: 0000-0002-7155-6079
authors.initials: B
authors.lastname: Yang
authors.affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510085, China; Kirby Institute, The University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Huachun
authors.identifier: 0000-0002-8161-7576
authors.initials: H
authors.lastname: Zou
mesh_terms: D000293:Adolescent; D000328:Adult; D001003:Anal Canal / Q000821:virology*; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D018451:Homosexuality, Male / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000502:physiology*; D012307:Risk Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data*; D014611:Vaccination; D055815:Young Adult
chemical_list: D004279:DNA, Viral