title: C. elegans as Model for Drug Discovery.
abstract: Small molecule screens using C. elegans as a model are becoming increasingly popular as the number of high-throughput methodologies has steadily increased over the years. Here we focus on the biology that underlies this increased popularity and outline the reasons that make C. elegans an attractive model for drug discovery. We discuss successful C. elegans based drug discovery projects in the literature and future challenges ahead.
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, United States.
authors.forename: Maria
authors.initials: M
authors.lastname: Carretero
authors.affiliation: Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Solis
authors.affiliation: Department of Chemical Physiology, Department of Molecular and Experimental Medicine, Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Petrascheck
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects*; D055808:Drug Discovery / Q000379:methods*; D023421:Models, Animal; D054852:Small Molecule Libraries / Q000494:pharmacology
chemical_list: D054852:Small Molecule Libraries
keywords: C. elegans; Cancer biology; Drug discovery; HTS; Nematodes; Vertebrate vascular endothelial growth factors