title: Efficacy and durability of hyaluronic acid fillers for malar enhancement: A prospective, randomized, split-face clinical controlled trial.
abstract: Various hyaluronic acid fillers can be used for facial attenuation and rejuvenation. The efficacy and durability of hyaluronic acid fillers are of major concern to dermatologists and patients. This study aimed to evaluate three-dimensional morphology, tissue distribution, and changes in volume after injection of two different hyaluronic acid fillers. Ten Korean women were enrolled in this study. Each subject was injected with monophasic hyaluronic acid filler in one malar area and biphasic filler in the other. Clinical outcome was measured before and after injection, and after 2, 4, 6, 8, 12, and 24 weeks, using the Global Aesthetic Improvement Scale, photographs and Moire's topography. Facial magnetic resonance imaging (MRI) was performed twice over six months. Both products showed good results after injection and demonstrated good durability over time. MRI was a useful modality for assessing tissue distribution and volume changes. The effects and durability after injection of monophasic hyaluronic acid filler and biphasic hyaluronic acid filler are generally comparable.
authors.affiliation: a Department of Dermatology , College of Medicine, Kyung Hee University , Seoul , Korea.
authors.forename: Ki Heon
authors.initials: KH
authors.lastname: Jeong
authors.affiliation: a Department of Dermatology , College of Medicine, Kyung Hee University , Seoul , Korea.
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Gwak
authors.affiliation: b Department of Radiology , College of Medicine, Kyung Hee University , Seoul , Korea.
authors.forename: Sung Kyung
authors.initials: SK
authors.lastname: Moon
authors.affiliation: c Arumdaun Nara Dermatologic Clinic , Seoul , Korea.
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: a Department of Dermatology , College of Medicine, Kyung Hee University , Seoul , Korea.
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Shin
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D000067548:Dermal Fillers / Q000737:chemistry / Q000627:therapeutic use*; D005145:Face; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000627:therapeutic use*; D007271:Injections, Intradermal; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D012060:Rejuvenation; D056910:Republic of Korea; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D000067548:Dermal Fillers; D006820:Hyaluronic Acid
keywords: Botulinum toxins; filler; hyaluronic acid; malar enhancement