title: Red blood cell distribution width and carotid intima-media thickness in patients with metabolic syndrome.
abstract: To evaluate the relationship between red blood cell distribution width (RDW) and carotid intima-media thickness (CIMT) in metabolic syndrome (MetS) patients.
  
  
  
  In this study, we analyzed 803 patients with MetS who underwent carotid ultrasonography examination at Henan Province Hospital of Traditional Chinese Medicine from October 2014 to September 2015. Demographic data were collected using a questionnaire. An automatic biochemistry analyzer measured RDW. Pearson correlation coefficient, multivariate linear and logistic regression was used to evaluate the correlation between RDW and CIMT.
  
  
  
  Compared with control group, case group had higher RDW level (P < 0.001) and CIMT (P < 0.001). CIMT was positively related to RDW (r = 0.436, P < 0.001). Logistic regression indicated that RDW was a predictor of CIMT ≥ 1 mm. Compared with the first quartile, people with third and fourth quartile level gave obvious higher risk of carotid artery atherosclerotic trend (OR = 1.41, 95% CI:1.01-197; OR = 2.10, 95% CI: 1.30-3.40). Using a cutoff point of 13.9%, RDW predicts elevated CIMT with a sensitivity of 62.1% and a specificity of 70.3%.
  
  
  
  High RDW is related to the increased CIMT in MetS patients, which highlights the role of RDW in the progression of elevated CIMT in MetS patients.
authors.affiliation: Emergency Department, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, 450002, People's Republic of China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Ren
authors.affiliation: Emergency Department, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, 450002, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Emergency Department, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, 450002, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, 450002, People's Republic of China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, Hunan Province, 410008, People's Republic of China. liche4006@126.com.
authors.forename: Zhanzhan
authors.initials: Z
authors.lastname: Li
mesh_terms: D000328:Adult; D019540:Area Under Curve; D002340:Carotid Artery Diseases / Q000097:blood* / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D016009:Chi-Square Distribution; D002681:China; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Carotid artery atherosclerosis; Metabolic syndrome; Red blood cell distribution width