title: Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome.
abstract: Duplications of Methyl CpG binding protein 2 (MECP2) -containing segments lead to the MECP2 duplication syndrome, in which severe autistic symptoms were identified. Whether adult neurogenesis may play a role in pathogenesis of autism and the role of MECP2 on state determination of adult neural stem cells (NSCs) remain largely unclear. Using a MECP2 transgenic (TG) mouse model for the MECP2 duplication syndrome, we found that adult hippocampal quiescent NSCs were significantly accumulated in TG mice comparing to wild type (WT) mice, the neural progenitor cells (NPCs) were reduced and the neuroblasts were increased in adult hippocampi of MECP2 TG mice. Interestingly, we found that parvalbumin (PV) positive interneurons were significantly decreased in MECP2 TG mice, which were critical for determining fates of adult hippocampal NSCs between the quiescence and activation. In summary, we found that MeCP2 plays a critical role in regulating fate determination of adult NSCs. These evidences further suggest that abnormal development of NSCs may play a role in the pathogenesis of the MECP2 duplication syndrome.
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Neonatology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yuan
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Dali
authors.initials: D
authors.lastname: Tong
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Yinqi
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Xia
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Neonatology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Lyu
authors.affiliation: Department of Neonatology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Xiuya
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Neonatology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
authors.affiliation: Department of Neonatology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Zhou
authors.affiliation: Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Kay Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Qiu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D018891:Dentate Gyrus; D004195:Disease Models, Animal; D015870:Gene Expression; D006624:Hippocampus / Q000166:cytology* / Q000378:metabolism*; D007395:Interneurons / Q000166:cytology / Q000378:metabolism; D038901:X-Linked Intellectual Disability / Q000235:genetics*; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D058953:Neural Stem Cells / Q000166:cytology / Q000502:physiology*; D055495:Neurogenesis; D016192:Resting Phase, Cell Cycle
chemical_list: C497393:Mecp2 protein, mouse; D051783:Methyl-CpG-Binding Protein 2