title: Cerebrolysin reduces mechanical allodynia in a rodent model of peripheral inflammation.
abstract: Cerebrolysin (Cbl) is a neuropeptide preparation of cerebroproteins that crosses the blood brain barrier displaying neuroprotective properties and promoting neurogenesis. Limited evidence exists on the efficacy of Cbl for the treatment of pain, with many studies focusing on neuropathic pain associated to diabetes. Therefore, we designed a study to test the hypothesis that Cbl would reduce mechanical allodynia in a rat model of peripheral inflammation induced by administration of complete Freund's adjuvant (CFA) in the hind paw. We found that acute administration of Cbl was effective in reducing mechanical allodynia but not peripheral inflammation in the CFA model of inflammatory pain. Our investigation supports further investigation into the therapeutic applications and mechanisms underlying the anti-allodynic effects of Cbl in inflammatory pain.
authors.affiliation: Centro de Investigación en Reproducción Animal, CINVESTAV- Universidad Autónoma de Tlaxcala, AP 62, CP 90000, Mexico. Electronic address: jmoralesm@cinvestav.mx.
authors.forename: Julio Cesar
authors.initials: JC
authors.lastname: Morales-Medina
authors.affiliation: Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: Natalie H
authors.initials: NH
authors.lastname: Griffiths
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla. 14 Sur 6301, Puebla, 72570, Mexico.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Flores
authors.affiliation: Facultad de Ciencias Básicas, Ingeniería y Tecnología, Universidad Autónoma de Tlaxcala, Calzada Apizaquito S/N, 90300, Apizaco, Tlaxcala, Mexico.
authors.forename: Virginia M
authors.initials: VM
authors.lastname: Mastranzo
authors.affiliation: KWS BioTest, Marine View Office Park, Portishead, Somerset, BS20 7AW, UK.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Iannitti
mesh_terms: D000596:Amino Acids / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology; D007249:Inflammation / Q000150:complications*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000596:Amino Acids; D018696:Neuroprotective Agents; C006952:cerebrolysin
keywords: Allodynia; Cerebrolysin; Complete Freund’s adjuvant; Peripheral inflammation