title: [Resection of a Huge Gastrointestinal Stromal Tumor of the Stomach Following Neoadjuvant Chemotherapy with Imatinib].
abstract: We report a case of a huge gastric gastrointestinal stromal tumor(GIST)that was safely resected followingpreoperative imatinib therapy. A 72-year-old woman was hospitalized with severe abdominal distension. Computed tomography revealed a 27×17 cm tumor in the left upper abdominal cavity. The patient was diagnosed with high risk GIST by EUS-FNA. We initiated preoperative adjuvant chemotherapy with imatinib to achieve a reduction of operative risks and functional preservation. After 6 months of chemotherapy, CT showed a reduction in the tumor size and the patient underwent partial gastrectomy and partial resection of the diaphragm. Histologically, most of the tumor cells were replaced by hyalinized collagen and viable cells were scattered only around the blood vessels. Neoadjuvant chemotherapy with imatinib has the potential to become an important therapeutic option for the treatment of huge GISTs.
authors.affiliation: Dept. of Surgery, Tohoku University Graduate School of Medicine.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sato
authors.forename: Hideaki
authors.initials: H
authors.lastname: Karasawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Imoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Tomoya
authors.initials: T
authors.lastname: Abe
authors.forename: Munenori
authors.initials: M
authors.lastname: Nagao
authors.forename: Shinobu
authors.initials: S
authors.lastname: Ohnuma
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Musha
authors.forename: Masanobu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Motoi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Naitoh
authors.forename: Chikashi
authors.initials: C
authors.lastname: Ishioka
authors.forename: Michiaki
authors.initials: M
authors.lastname: Unno
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use*; D020360:Neoadjuvant Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate