title: Successful Treatment of Hypersplenism in Wilson's Disease by Partial Splenic Embolization.
abstract: OBJECTIVE
  Hypersplenism can occur in patients with Wilson's disease (WD). Surgical splenectomy is a conventional treatment for this condition; however, emotional and neurological deterioration may follow splenectomy. In recent years, partial splenic embolization (PSE) has been increasingly performed as a nonsurgical alternative treatment for hypersplenism. The aim of this study was to evaluate the effectiveness and safety of PSE compared with splenectomy in the treatment of hypersplenism in WD patients.
  
  
  METHODS
  Fifty WD patients with hypersplenism were randomly divided into two groups (group A and group B), each including 25 patients. Patients in groups A and B were treated with PSE and splenectomy, respectively. Data were collected on the clinical efficacy of each procedure, adverse reactions, hematologic and blood chemistry test results, and abdominal computed tomography (CT) scan findings (group A only).
  
  
  RESULTS
  Marked improvements in the platelet and leukocyte counts after PSE and splenectomy were observed in all patients. PSE was associated with improved liver function without severe complications, and no significant changes in emotional and neurological symptoms were observed. In contrast, seven WD patients suffered neurological deterioration after splenectomy.
  
  
  CONCLUSIONS
  Hypersplenism in WD patients was successfully treated by PSE, which appears to be a safe and effective alternative treatment for WD-induced hypersplenism.
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine , Hefei , China.
authors.forename: Liang-Yong
authors.initials: LY
authors.lastname: Li
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine , Hefei , China.
authors.forename: Huai-Zhen
authors.initials: HZ
authors.lastname: Chen
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine , Hefei , China.
authors.forename: Yuan-Cheng
authors.initials: YC
authors.lastname: Bao
authors.affiliation: b Department of General Surgery , the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine , Hefei , China.
authors.forename: Qing-Sheng
authors.initials: QS
authors.lastname: Yu
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine , Hefei , China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D057785:Catheters; D000529:Complementary Therapies / Q000379:methods*; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications*; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000209:etiology / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013154:Spleen / Q000503:physiopathology / Q000601:surgery; D013156:Splenectomy; D016896:Treatment Outcome; D055815:Young Adult
keywords: Wilson's disease; hypersplenism; neurological deterioration; partial splenic embolization; sodium 2,3-dimercapto-1-propane sulfonate (DMPS); splenectomy