title: Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population.
abstract: An Indian study recently observed three new loci: rs9552911 in theSGCG, rs1593304 nearPLXNA4and rs4858889 inSCAPassociated with type 2 diabetes mellitus (T2DM) in a south Asian population. The present study aimed to validate these findings in a Chinese population. We genotyped the above three single-nucleotide polymorphisms (SNPs), rs9552911, rs1593304, and rs4858889, in a group of 1,972 Chinese individuals, comprising of 966 type 2 diabetic patients and 976 controls. Anthropometric variables and biochemical traits were measured in all the participants. The association analyses of genotype-disease and genotype-traits were estimated. The genotype frequency of rs9552911 differed statistically between the cases and controls (P=0.017). The difference was also evident between the cases and controls in non-obese participants (P=0.033). In addition, the SNP rs9552911 was associated with weight (P=0.033), total cholesterol (P=0.006) and low-density lipoprotein-cholesterol (P=0.007). The SNP rs1593304 was associated with β-cell function estimated by the homeostatic model assessment of β-cell function (P=0.041). However, there was no significant association between rs4858889 and T2DM. In conclusion, the results show that the SNP rs9552911 was associated with T2DM, possibly by affecting body mass index and lipid metabolism. The SNP rs1593304 may impair β-cell function.
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
authors.forename: Meijun
authors.initials: M
authors.lastname: Chen
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
authors.forename: Xuelong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
authors.forename: Qingxiao
authors.initials: Q
authors.lastname: Fang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Qiao
keywords: PLXNA4: rs1593304; SCAP: rs4858889; SGCG: rs9552911; single-nucleotide polymorphisms; type 2 diabetes mellitus