title: High-Resolution 4D Preclinical Single-Photon Emission Computed Tomography/X-ray Computed Tomography Imaging of Technetium Transport within a Heterogeneous Porous Media.
abstract: A dynamic99mTc tracer experiment was performed to investigate the capabilities of combined preclinical single photon emission computed tomography (SPECT) and X-ray computed tomography (CT) for investigating transport in a heterogeneous porous medium. The experiment was conducted by continuously injecting a99mTc solution into a column packed with eight layers (i.e., soil, silica gel, and 0.2-4 mm glass beads). Within the imaging results it was possible to correlate observed features with objects as small as 2 mm for the SPECT and 0.2 mm for the CT. Time-lapse SPECT imaging results illustrated both local and global nonuniform transport phenomena and the high-resolution CT data were found to be useful for interpreting the cause of variations in the99mTc concentration associated with structural features within the materials, such as macropores. The results of this study demonstrate SPECT/CT as a novel tool for 4D (i.e., transient three-dimensional) noninvasive imaging of fate and transport processes in porous media. Despite its small scale, an experiment with such high resolution data allows us to better understand the pore scale transport which can then be used to inform larger scale studies.
authors.affiliation: Environmental Engineering and Earth Sciences, Clemson University , Clemson, South Carolina 29634, United States.
authors.forename: Mine
authors.identifier: 0000-0001-7222-4490
authors.initials: M
authors.lastname: Dogan
authors.affiliation: Environmental Engineering and Earth Sciences, Clemson University , Clemson, South Carolina 29634, United States.
authors.forename: Stephen M J
authors.initials: SM
authors.lastname: Moysey
authors.affiliation: MILabs, 3584 CX Utrecht, The Netherlands.|Section Radiation, Detection & Medical Imaging, TU-Delft , 2628 CD Delft, The Netherlands.
authors.forename: Ruud M
authors.initials: RM
authors.lastname: Ramakers
authors.affiliation: Environmental Engineering and Earth Sciences, Clemson University , Clemson, South Carolina 29634, United States.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: DeVol
authors.affiliation: MILabs, 3584 CX Utrecht, The Netherlands.|Section Radiation, Detection & Medical Imaging, TU-Delft , 2628 CD Delft, The Netherlands.
authors.forename: Frederik J
authors.initials: FJ
authors.lastname: Beekman
authors.affiliation: MILabs, 3584 CX Utrecht, The Netherlands.
authors.forename: Harald C
authors.initials: HC
authors.lastname: Groen
authors.affiliation: Environmental Engineering and Earth Sciences, Clemson University , Clemson, South Carolina 29634, United States.
authors.forename: Brian A
authors.identifier: 0000-0003-0423-0180
authors.initials: BA
authors.lastname: Powell
mesh_terms: D019275:Radiopharmaceuticals; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium