title: Interstitial Photodynamic Therapy-A Focused Review.
abstract: Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response.
authors.affiliation: Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. Gal.Shafirstein@RoswellPark.org.
authors.forename: Gal
authors.initials: G
authors.lastname: Shafirstein
authors.affiliation: Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. David.Bellnier@RoswellPark.org.
authors.forename: David
authors.initials: D
authors.lastname: Bellnier
authors.affiliation: Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. Emily.Oakley@RoswellPark.org.
authors.forename: Emily
authors.initials: E
authors.lastname: Oakley
authors.affiliation: Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. Sasheen.Hamilton@RoswellPark.org.
authors.forename: Sasheen
authors.initials: S
authors.lastname: Hamilton
authors.affiliation: Simphotek, Inc., 211 Warren St, Newark, NJ 07103, USA. mpotasek@simphotek.com.
authors.forename: Mary
authors.initials: M
authors.lastname: Potasek
authors.affiliation: Simphotek, Inc., 211 Warren St, Newark, NJ 07103, USA. beesonk@simphotek.com.
authors.forename: Karl
authors.initials: K
authors.lastname: Beeson
authors.affiliation: Simphotek, Inc., 211 Warren St, Newark, NJ 07103, USA. evp@simphotek.com.
authors.forename: Evgueni
authors.initials: E
authors.lastname: Parilov
keywords: brain; head and neck; interstitial photodynamic therapy; pancreatic; prostate; treatment planning