title: Squamous cell carcinoma with enteric adenocarcinomatous differentiation.
abstract: We report a highly unusual case of a primary cutaneous squamous cell carcinoma (SCC) with intermixed enteric-type adenocarcinomatous dedifferentiation and a small component of undifferentiated mesenchymal differentiation. We believe this is the first time this form of phenotypic plasticity has been described in cutaneous SCC.
authors.affiliation: Department of Pathology and Molecular Medicine, University of Auckland, Auckland, New Zealand.|Division of Dermatopathology, Mount Sinai Medical Center, New York, New York.
authors.forename: Patrick O
authors.identifier: http://orcid.org/0000-0003-1068-6969
authors.initials: PO
authors.lastname: Emanuel
authors.affiliation: Division of Dermatopathology, Mount Sinai Medical Center, New York, New York.
authors.forename: Garrett
authors.identifier: http://orcid.org/0000-0002-1557-300X
authors.initials: G
authors.lastname: Desman
authors.affiliation: Skin Dermatology Institute, Tauranga, New Zealand.|Pathlab Bay of Plenty, Tauranga, New Zealand.
authors.forename: Ben
authors.initials: B
authors.lastname: Tallon
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D054337:Cell Dedifferentiation; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
keywords: CDX-2; adenocarcinoma; collision; squamous cell carcinoma; trans-differentiation