title: A case of endometrial carcinoma in a long-term Levonorgestrel Intrauterine System (LNG 52 mg-IUS) user.
abstract: This report describes a 50-year-old woman who presented to a community gynaecology clinic complaining of persistent heavy vaginal bleeding with an LNG 52 mg-IUS in situ. She was subsequently found to have stage 1 grade 1a endometrioid carcinoma. From the literature, we have identified five similar cases. This case highlights the possibility of endometrial carcinoma despite treatment with an LNG 52 mg-IUS and reinforces the importance of investigating women who present with unusual persistent or heavy vaginal bleeding.
authors.affiliation: Southport and Ormskirk Hospital NHS Trust, Southport, UK.
authors.forename: Melisa
authors.initials: M
authors.lastname: Thomas
authors.affiliation: Southport and Ormskirk Hospital NHS Trust, Southport, UK.
authors.forename: Paula
authors.initials: P
authors.lastname: Briggs
mesh_terms: D018269:Carcinoma, Endometrioid / Q000150:complications / Q000175:diagnosis*; D003271:Contraceptive Agents, Female; D016889:Endometrial Neoplasms / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel; D008875:Middle Aged; D014592:Uterine Hemorrhage / Q000209:etiology*
chemical_list: D003271:Contraceptive Agents, Female; D016912:Levonorgestrel
keywords: HRT; perimenopause