title: Domino Synthesis of Thiochromenes through Cu-Catalyzed Incorporation of Sulfur Using Xanthate Surrogate.
abstract: An efficient domino reaction has been developed for the synthesis of thiochromenes through Cu-catalyzed in situ incorporation of sulfur. This domino method avoids the use of less accessible and unpleasant arenethiols as starting materials, instead utilizes very stable aryl halides along with potassium ethyl xanthate as an odorless sulfur surrogate. The domino methodology proceeds through C(aryl)-S coupling, thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reaction sequences to provide thiochromenes in good yields.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai, 600036 Tamil Nadu, India.
authors.forename: Pandi
authors.initials: P
authors.lastname: Muthupandi
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai, 600036 Tamil Nadu, India.
authors.forename: Nallappan
authors.initials: N
authors.lastname: Sundaravelu
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai, 600036 Tamil Nadu, India.
authors.forename: Govindasamy
authors.identifier: 0000-0003-2294-0485
authors.initials: G
authors.lastname: Sekar