title: RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection.
abstract: RNA binding motif 3 (RBM3) is a highly conserved cold-induced RNA binding protein that is transcriptionally up-regulated in response to harsh stresses. Featured as RNA binding protein, RBM3 is involved in mRNA biogenesis as well as stimulating protein synthesis, promoting proliferation and exerting anti-apoptotic functions. Nowadays, accumulating immunohistochemically studies have suggested RBM3 function as a proto-oncogene that is associated with tumor progression and metastasis in various cancers. Moreover, emerging evidences have also indicated that RBM3 is equally effective in neuroprotection. In the present review, we provide an overview of current knowledge concerning the role of RBM3 in various cancers and neuroprotection. Additionally, its potential roles as a promising diagnostic marker for cancer and a possible therapeutic target for neuro-related diseases are discussed.
authors.affiliation: Key Laboratory for Space Bioscience & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
authors.forename: Ren-Bin
authors.initials: RB
authors.lastname: Zhou
authors.affiliation: Key Laboratory for Space Bioscience & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Lu
authors.affiliation: Key Laboratory for Space Bioscience & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
authors.forename: Chen-Yan
authors.initials: CY
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Space Bioscience & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
authors.forename: Da-Chuan
authors.initials: DC
authors.lastname: Yin
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D000066829:Neuroprotection / Q000187:drug effects*; D000090063:Proto-Oncogene Mas; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; C099506:RBM3 protein, human; D016601:RNA-Binding Proteins
keywords: RNA binding protein 3; biomarker; cancer; neuroprotection