title: Coronary Spasm after an Injection of Vincristine.
abstract: Cardiotoxicity, including heart failure, thromboembolic events, and myocardial ischemia, is a concern for cardiologists and oncologists. The most frequently involved drugs are anthracyclines. We report an episode of coronary spasm due to vincristine, a vinca alkaloid, in a 49-year-old man treated for a diffuse undifferentiated carcinoma. The patient suffered recurrent episodes of typical chest pain with ST-elevation in the inferior area. Coronary spasm was confirmed by an angiogram, which showed normal coronary arteries. No recurrence occurred with the medical management. Coronary spasm induced by vincristine is a newly described facet of chemotherapy-related cardiotoxicity.
authors.affiliation: Intensive Care Unit, Centre Hospitalier Métropole-Savoie, Chambéry, France.
authors.forename: Rosine
authors.initials: R
authors.lastname: Gros
authors.forename: Vincent
authors.initials: V
authors.lastname: Hugon
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Thouret
authors.forename: Vincent
authors.initials: V
authors.lastname: Peigne
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000175:diagnosis* / Q000209:etiology; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D019210:Troponin I / Q000032:analysis; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D019210:Troponin I; D014750:Vincristine