title: [Surgical Resection of Solitary Brain Metastasis from Breast Cancer].
abstract: BACKGROUND
  Brain metastasis from breast cancer has a poor prognosis. For solitary cerebral metastases, surgical resection may contribute to the improvement of survival and QOL. We studied the prognosis and characteristics of solitary brain metastasis from breast cancer in patients undergoing surgical resection.
  
  
  METHODS
  Seventeen patients had tumors metastatic to the brain at Kasukabe Municipal Hospital between June 2009 and May 2016, and 7 of them underwent craniotomy. Their treatment outcomes were analyzed retrospectively.
  
  
  RESULTS
  The median age at diagnosis of brain metastasis was 56 years. The median survival duration was 19.6 months. With regard to radiation therapy after surgery, 3 patients received whole brain irradiation, 2 patients received stereotactic brain irradiation, and 2 patients received both. The site of brain metastasis was the cerebellum in 6 patients, and the occipital lobe in 1 patient. The number of HER2-positive breast cancer patients was 5, and lapatinib and capecitabine were administered to 4 out of these 5 patients.
  
  
  CONCLUSIONS
  For solitary brain metastasis, the improvement in symptoms and the extension of the survival can be achieved using multidisciplinary treatment with surgery, radiation, and molecular targeting drugs.
authors.affiliation: Dept. of Breast Surgery, Kasukabe Medical Center.
authors.forename: Kei
authors.initials: K
authors.lastname: Kimizuka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyake
authors.forename: Junko
authors.initials: J
authors.lastname: Sugiyama
authors.forename: Michitaka
authors.initials: M
authors.lastname: Ogura
authors.forename: Nozomi
authors.initials: N
authors.lastname: Kamisada
authors.forename: Moritaka
authors.initials: M
authors.lastname: Ohhara
authors.forename: Woodae
authors.initials: W
authors.lastname: Kang
authors.forename: Reona
authors.initials: R
authors.lastname: Katoh
authors.forename: Hironobu
authors.initials: H
authors.lastname: Satoh
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yokose
authors.forename: Shoshi
authors.initials: S
authors.lastname: Satoh
authors.forename: Masamichi
authors.initials: M
authors.lastname: Fukushima
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D003399:Craniotomy; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome