title: Case report of male child with elevated lipoprotein (a) leading to acute ischemic stroke.
abstract: Acute ischemic stroke (AIS) in children is rare with almost 40% diagnosed as cryptogenic. One possible mechanism associated with AIS is an elevated Lipoprotein (a) [Lp(a)] level. Here, we discuss the case of an 11-year old boy who presented with multiple thrombotic strokes secondary to elevated Lp(a), which was identified as the only risk factor and immediately treated with lipoprotein apheresis (LA). Eighteen months post-AIS, he is still receiving LA treatments and has made remarkable progress in his recovery without another cerebrovascular event.
authors.affiliation: Division of Clinical Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Patrick M
authors.identifier: http://orcid.org/0000-0001-6189-355X
authors.initials: PM
authors.lastname: Moriarty
authors.affiliation: Division of Clinical Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Tennant
authors.affiliation: Division of Clinical Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Nandhini
authors.initials: N
authors.lastname: Sehar
authors.affiliation: Division of Clinical Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Lauryn
authors.initials: L
authors.lastname: Denney
authors.affiliation: Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Paola
authors.initials: P
authors.lastname: Luna
authors.affiliation: Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Francesca
authors.initials: F
authors.lastname: Perez-Marques
authors.affiliation: Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Apurva
authors.initials: A
authors.lastname: Panchal
authors.affiliation: Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Abraham
authors.affiliation: Department of Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: John
authors.initials: J
authors.lastname: Leever
mesh_terms: D001781:Blood Component Removal / Q000379:methods; D002648:Child; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood* / Q000302:isolation & purification; D008297:Male; D020521:Stroke / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D013927:Thrombosis / Q000097:blood
chemical_list: D017270:Lipoprotein(a)
keywords: acute ischemic stroke; lipoprotein (a); lipoprotein apheresis; multiple thrombotic strokes; pediatric stroke