title: Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer.
abstract: Pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition (EMT) has gained increasing research focus. The process is implicated in tumour metastasis, and emerging evidence suggests EMT also contributes or induces chemoresistance in several cancers. Nevertheless, the applicability of therapeutic targeting of EMT faces many challenges. In this mini-review, we summarise the evidence supporting the role of EMT in pancreatic cancer progression, focusing particularly on its association with chemoresistance.
authors.affiliation: Omar Elaskalani, Norbaini Binti Abdol Razak, Pat Metharom, Platelet Research Laboratory, Curtin Health Innovation and Research Institute, Department of Health Sciences, Curtin University, Perth, Western Australia 6102, Australia.
authors.forename: Omar
authors.initials: O
authors.lastname: Elaskalani
authors.affiliation: Omar Elaskalani, Norbaini Binti Abdol Razak, Pat Metharom, Platelet Research Laboratory, Curtin Health Innovation and Research Institute, Department of Health Sciences, Curtin University, Perth, Western Australia 6102, Australia.
authors.forename: Norbaini Binti Abdol
authors.initials: NB
authors.lastname: Razak
authors.affiliation: Omar Elaskalani, Norbaini Binti Abdol Razak, Pat Metharom, Platelet Research Laboratory, Curtin Health Innovation and Research Institute, Department of Health Sciences, Curtin University, Perth, Western Australia 6102, Australia.
authors.forename: Marco
authors.initials: M
authors.lastname: Falasca
authors.affiliation: Omar Elaskalani, Norbaini Binti Abdol Razak, Pat Metharom, Platelet Research Laboratory, Curtin Health Innovation and Research Institute, Department of Health Sciences, Curtin University, Perth, Western Australia 6102, Australia.
authors.forename: Pat
authors.initials: P
authors.lastname: Metharom
keywords: Chemotherapy; Drug resistance; Epithelial-mesenchymal transition; Pancreatic cancer