title: A comparison of neurometabolites between remitted bipolar disorder and depressed bipolar disorder: A proton magnetic resonance spectroscopy study.
abstract: Recent many studies found the abnormal neurometabolites in the acute bipolar disorder (BD). However, limited studies were to detect neurometabolites in remitted BD, comparison between acute and remitted BD is conductive to understand the outcome of neurometabolites. This study sought to investigate the differences in neurometabolites between remitted and depressed BD patients using proton magnetic resonance spectroscopy (1H-MRS).
  
  
  
  Three subject groups were enrolled: 22 remitted BD patients, 22 depressed BD patients and 24 healthy controls. All subjects underwent1H-MRS to measure N-acetylaspartate (NAA), Choline (Cho), myo-Inositol (mI) and Creatine (Cr) of several bilateral areas potentially involved in BD: prefrontal whiter matter (PWM), thalamus and putamen. The neurometabolite ratios were compared among three groups. The correlations between abnormal neurometabolite ratios and clinical data were computed.
  
  
  
  The lower bilateral PWM NAA/Cr ratios were found in depressed BD patients than remitted BD patients and healthy controls, no differences were found between the remitted BD patients and controls. For depressed BD patients, left PWM NAA/Cr ratios showed negative correlation with age of onset, right PWM NAA/Cr ratios showed positive correlation with duration of illness.
  
  
  
  Our findings suggest the abnormal neurometabolites in the prefrontal lobe whiter may occur in the depressed BD. The remitted BD may resemble healthy subjects in terms of neurometabolites. In addition, abnormal neurometabolites in prefrontal lobe whiter may correlate with the age of onset and illness length.
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China; The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou 510370, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Shuming
authors.initials: S
authors.lastname: Zhong
authors.affiliation: Department of Affective Disorder, Shenzhen Mental Health Center, Shenzheng 518000, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Shunkai
authors.initials: S
authors.lastname: Lai
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China. Electronic address: Yanbinjia2006@163.com.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000378:metabolism*; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods; D066127:White Matter
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
keywords: Depressed bipolar disorder; Neurometabolite; Proton magnetic resonance spectroscopy; Remitted bipolar disorder