title: Chronic Eyelid Edema Following Periocular Hyaluronic Acid Filler Treatment.
abstract: A 54-year-old woman received multiple injections of hyaluronic acid filler to the brow region to address volume loss over a 21-month period. She then developed significant pitting edema of both upper eyelids, which persisted for 6 years. Hyaluronidase (Hyalase) was injected into the subcutaneous brows and resulted in complete resolution of the edema within 2 days. This confirms that the hyaluronic acid injected into the brows was responsible for this patient's chronic eyelid edema. This case illustrates an unusual long-term complication of periocular hyaluronic acid filler.
authors.affiliation: *Manchester Royal Eye Hospital, Manchester, M13 9WL; and †School of Medicine, University of Manchester, Manchester M13 9PT, United Kingdom.
authors.forename: Jonathan T S
authors.initials: JTS
authors.lastname: Yu
authors.forename: Liam
authors.initials: L
authors.lastname: Peng
authors.forename: Sajid
authors.initials: S
authors.lastname: Ataullah
mesh_terms: D003357:Cosmetic Techniques / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced*; D005141:Eyelid Diseases / Q000139:chemically induced*; D005143:Eyelids / Q000187:drug effects*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D007267:Injections; D008875:Middle Aged; D055675:Viscosupplements / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid