title: Human papillomavirus infections among women with cervical lesions and cervical cancer in Eastern China: genotype-specific prevalence and attribution.
abstract: Cervical cancer and its precursor, high-grade cervical intraepithelial neoplasia (CIN2/3), are associated with persistent high-risk human papillomavirus (HPV) infection. HPV genotype prevalence varies with severity of cervical lesions, patient age and geographical location. The aim of this study was to investigate HPV genotypes prevalence and attribution according to the severity of cervical lesions among Chinese women.
  
  
  
  A 4-year surveillance study was performed. A total of 1664 female patients were included and their cervical histological diagnosis consisted of cervical intraepithelial neoplasia grade 1 (CIN1, 376 cases), grade 2 (CIN2, 408 cases), grade 3 (CIN3, 336 cases) and invasive cervical cancers (ICC, 544 cases). HPV genotypes prevalence and attribution to cervical lesions were calculated and analyzed. The 95% confidence interval (CI) for proportion was also calculated.
  
  
  
  HPV positivity rates increased directly with cervical lesions severity (72.4% for CIN1, 81.4% for CIN2, 88.1% for CIN3 and 90.4% for ICC). Infections with multiple HPV types were inversely related to cervical lesions severity. HPV16, 52, 31, 33 and 58 were the most prevalent genotypes in ICC. 49.1% of squamous cell carcinoma, 65.1% of adenocarcinoma and 12.0-43.3% of cervical intraepithelial neoplasia could be attributed to vaccine-covered high-risk genotypes (HPV16/18). Inclusion of HPV52 and HPV31 in future vaccines would provide the highest marginal benefit in protection for individuals residing in this region.
  
  
  
  These findings provide information about HPV genotypes in this region which may be important to target with future vaccination and screening programs.
authors.affiliation: Department of Laboratory Medicine, Qingdao Central Hospital, Second Affiliated Hospital of Qingdao University, Siliunan Road #127, Qingdao, 266042, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, Qingdao Central Hospital, Second Affiliated Hospital of Qingdao University, Siliunan Road #127, Qingdao, 266042, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Bi
authors.affiliation: Department of Laboratory Medicine, Qingdao Central Hospital, Second Affiliated Hospital of Qingdao University, Siliunan Road #127, Qingdao, 266042, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Pathology, Qingdao Central Hospital, Qingdao, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Laboratory Medicine, Qingdao Central Hospital, Second Affiliated Hospital of Qingdao University, Siliunan Road #127, Qingdao, 266042, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, Qingdao Cancer Hospital, Qingdao, China.
authors.forename: Meilian
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, Qingdao Central Hospital, Second Affiliated Hospital of Qingdao University, Siliunan Road #127, Qingdao, 266042, China. zxyymuxf@yeah.net.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Mu
mesh_terms: D044466:Asian People; D002681:China / Q000453:epidemiology; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology; D016387:Women's Health; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000821:virology
keywords: Attribution; Cervical cancer; Genotypes; Human papillomavirus