title: Sickle Cell Trait and Renal Function in Hispanics in the United States: The Northern Manhattan Study.
abstract: Sickle cell anemia (SCA) is a common hematological disorder among individuals of African descent in the United States; the disorder results in the production of abnormal hemoglobin. It is caused by homozygosity for a genetic mutation in HBB; rs334. While the presence of a single mutation (sickle cell trait, SCT) has long been considered a benign trait, recent research suggests that SCT is associated with renal dysfunction, including a decrease in estimated glomerular filtration rate (eGFR) and increased risk of chronic kidney disease (CKD) in African Americans. It is currently unknown whether similar associations are observed in Hispanics. Therefore, our study aimed to determine if SCT is associated with mean eGFR and CKD in a sample of 340 Dominican Hispanics from the Northern Manhattan Study. Using regression analyses, we tested rs334 for association with eGFR and CKD, adjusting for age and sex. eGFR was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation and CKD was defined as eGFR < 60 mL/min/1.73 m2. Within our sample, there were 16 individuals with SCT (SCT carriers). We found that SCT carriers had a mean eGFR that was 12.12 mL/min/1.73m2lower than non-carriers (P=.002). Additionally, SCT carriers had 2.72 times higher odds of CKD compared with non-carriers (P=.09). Taken together, these novel results show that Hispanics with SCT, as found among African Americans with SCT, may also be at increased risk for kidney disease.
authors.affiliation: John P. Hussman Institute for Human Genomics, University of Miami.
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Dueker
authors.affiliation: Department of Neurology, Epidemiology and Public Health, Miller School of Medicine, University of Miami; Department of Systems Medicine, School of Medicine, University of Rome 'Tor Vergata', Rome; IRCCS, San Raffaele Pisana, Rome.
authors.forename: David
authors.initials: D
authors.lastname: Della-Morte
authors.affiliation: Department of Neurology, Epidemiology and Public Health, Miller School of Medicine, University of Miami.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Rundek
authors.affiliation: Department of Neurology, Epidemiology and Public Health, Miller School of Medicine, University of Miami; Dr. John T. Macdonald Department of Human Genetics, University of Miami.
authors.forename: Ralph L
authors.initials: RL
authors.lastname: Sacco
authors.affiliation: John P. Hussman Institute for Human Genomics, University of Miami; Dr. John T. Macdonald Department of Human Genetics, University of Miami.
authors.forename: Susan H
authors.initials: SH
authors.lastname: Blanton
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics; D000368:Aged; D000755:Anemia, Sickle Cell / Q000235:genetics; D015331:Cohort Studies; D004293:Dominican Republic / Q000208:ethnology; D005260:Female; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005919:Glomerular Filtration Rate / Q000235:genetics*; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009519:New York City; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000235:genetics*; D012805:Sickle Cell Trait / Q000235:genetics*; D014481:United States
keywords: Chronic Kidney Disease (CKD); Hispanics; Sickle Cell Trait