title: Peripheral vein infusions of amino acids facilitate recovery after esophagectomy for esophageal cancer: Retrospective cohort analysis.
abstract: BACKGROUND
  To investigate the efficacy of amino acid administration via peripheral veins in addition to conventional enteral feeding following esophagectomy.
  
  
  METHODS
  Retrospective analysis of data pertaining to 33 patients with esophageal cancer who underwent radical esophagectomy and satisfied the required nutrition control. Patients were divided into the amino acid group (n = 17) and control group (n = 16). Primary outcomes were albumin (Alb) and prealbumin (PreAlb) levels, urinary 3-methylhistidine/creatinine (3-MeHis/Cre) ratios, nitrogen balance, and weight; postoperative complications were noted as secondary outcomes.
  
  
  RESULTS
  Alb levels were significantly higher in the amino acid group on postoperative day (POD)-14 (3.4 ± 0.3 vs. 3.1 ± 0.4 mg/dL in the control group,p= 0.018) and at 1 month after surgery (3.8 ± 0.4 vs. 3.5 ± 0.3 mg/dL,p= 0.045). No significant differences were observed in PreAlb and urinary 3-MeHis/Cre rates between the treatment groups. Body weights at 3 months postoperatively were decreased by 6% and 3% in the control and amino acid groups, respectively.
  
  
  CONCLUSIONS
  Peripheral venous administration of amino acids soon after surgical stress is an effective method for nutritional control.
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Konosu
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwaya
authors.affiliation: Department of Palliative Care Medicine, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Akiyama
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shioi
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Endo
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nitta
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Otsuka
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Koeda
authors.affiliation: Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sasaki
keywords: Amino acid; Esophagectomy; Nutrition control; Peripheral vein infusion; Surgical stress