title: Disseminated Nonleukemic Myeloid Sarcoma of the Spleen With Involvement of the Liver in an Infant.
abstract: Nonleukemic myeloid sarcoma (MS) is a rare tumor that can occur in several locations without myeloid leukemia. We reported a first case of nonleukemic MS of the spleen involving the liver in a 5-month-old boy presenting with hematochezia, petechial hemorrhage, fever, and hepatosplenomegaly. Bone marrow trephine biopsy and immunophenotypic flow cytometry revealed no evidence of myeloid leukemia. The patient underwent liver biopsy and splenectomy. Clinicopathology and immunohistochemistry suggested a disseminated nonleukemic MS. The patient died of respiratory failure on the seventh postoperative day. Early diagnosis of a disseminated nonleukemic MS may be quite important for patient survival and it should be considered one of the differential diagnoses of hepatosplenomegaly with atypical clinical features.
authors.affiliation: *Zhejiang University School of Medicine, 117 Hospital of People's Liberation Army †Division of Hematology and Oncology, Children's Hospital, Zhejiang University School of Medicine ‡Department of Pathology, Children's Hospital, Zhejiang University School of Medicine §Clinical Lab, Children's Hospital, Zhejiang University School of Medicine ∥Department of Medical Microbiology and Parasitology, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Yueli
authors.initials: Y
authors.lastname: Rao
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wu
authors.forename: Ao
authors.initials: A
authors.lastname: Dong
authors.forename: Kun
authors.initials: K
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Shenyang
authors.initials: S
authors.lastname: Cai
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006529:Hepatomegaly; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D023981:Sarcoma, Myeloid / Q000175:diagnosis*; D013160:Splenic Neoplasms / Q000175:diagnosis*; D013163:Splenomegaly