title: Flavonoids from Erythrina schliebenii.
abstract: Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2-4), and nineteen known natural products (5-23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32-64 μg mL-1and 36.9-101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50values of 13.0-290.6 μM (pure compounds) and 38.3 to >100 μg mL-1(crude extracts).
authors.affiliation: Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam , P.O. Box 35061, Dar es Salaam, Tanzania.|Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg SE-412 96, Sweden.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Nyandoro
authors.affiliation: Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam , P.O. Box 35061, Dar es Salaam, Tanzania.|Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg SE-412 96, Sweden.
authors.forename: Joan J E
authors.initials: JJ
authors.lastname: Munissi
authors.affiliation: Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam , P.O. Box 35061, Dar es Salaam, Tanzania.
authors.forename: Msim
authors.initials: M
authors.lastname: Kombo
authors.affiliation: Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam , P.O. Box 35061, Dar es Salaam, Tanzania.
authors.forename: Clarence A
authors.initials: CA
authors.lastname: Mgina
authors.affiliation: Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box. 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Pan
authors.affiliation: Sahlgrenska Cancer Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
authors.forename: Amra
authors.initials: A
authors.lastname: Gruhonjic
authors.affiliation: Sahlgrenska Cancer Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
authors.forename: Paul
authors.initials: P
authors.lastname: Fitzpatrick
authors.affiliation: Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute , Beijing 101149, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute , Beijing 101149, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box. 35, FI-40014 University of Jyvaskyla, Finland.
authors.forename: Kari
authors.identifier: 0000-0002-7282-8419
authors.initials: K
authors.lastname: Rissanen
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg SE-412 96, Sweden.|Swedish NMR Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
authors.forename: Máté
authors.identifier: 0000-0003-0359-5970
authors.initials: M
authors.lastname: Erdélyi
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004895:Erythrina / Q000145:classification*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D013636:Tanzania
chemical_list: D000995:Antitubercular Agents; D005419:Flavonoids