title: Metal-organic-framework-supported immunostimulatory oligonucleotides for enhanced immune response and imaging.
abstract: We have demonstrated the ability of iron carboxylate metal-organic frameworks to efficiently deliver unmethylated cytosine-phosphate-guanine oligonucleotides. The nanoconjugates induced a stronger immune response than did free cytosine-phosphateguanine oligonucleotides and showed T2-magnetic resonance imaging ability both in vitro and in vivo.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Liu
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Faming
authors.initials: F
authors.lastname: Wang
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Jinsong
authors.identifier: http://orcid.org/0000-0002-7506-627X
authors.initials: J
authors.lastname: Ren
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Xiaogang
authors.identifier: http://orcid.org/0000-0003-2868-3205
authors.initials: X
authors.lastname: Qu
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry*; D000818:Animals; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D009841:Oligonucleotides / Q000737:chemistry* / Q000276:immunology*; D009942:Organometallic Compounds / Q000737:chemistry*; D010316:Particle Size; D000067996:RAW 264.7 Cells; D013499:Surface Properties
chemical_list: D000276:Adjuvants, Immunologic; D009841:Oligonucleotides; D009942:Organometallic Compounds