title: Maoa and Maob polymorphisms and personality traits in suicide attempters and healthy controls: a preliminary study.
abstract: Serotonergic neurotransmission dysfunctions have been well documented in patients with suicidal behaviour. We investigated monoamine oxidase A (MAOA: rs2064070, rs6323, rs909525) and B (MAOB: rs1799836, rs2311013, rs2205655) genetic modulation of personality traits (Temperament and Character Inventory, TCI) as endophenotype for suicidal behaviour. 108 suicide attempters and 286 healthy controls of German origin were screened. Among females, allelic analyses revealed associations between MAOA rs6323 A allele and higher Harm Avoidance in suicide attempters and MAOB rs2205655 A allele and higher Cooperativeness scores in healthy controls. Among males, MAOA rs909525 A allele was associated with higher Reward Dependence in suicide attempters. Multivariate analyses controlling for age and educational level mainly confirmed results. Case-control analyses in this subsample do not differ from our previously reported one. Despite of the small sample size, a possible involvement of these genes in the modulation of personality traits closely related to suicidal behaviour cannot be excluded.
authors.affiliation: Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Balestri
authors.affiliation: INSERM U1061, University of Montpellier UM1, FondaMental Foundation, Montpellier, France.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Calati
authors.affiliation: Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. Electronic address: alessandro.serretti@unibo.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.affiliation: Department of Psychiatry, University of Halle, Halle, Germany.
authors.forename: Annette M
authors.initials: AM
authors.lastname: Hartmann
authors.affiliation: Department of Psychiatry, University of Halle, Halle, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Konte
authors.affiliation: Department of Psychiatry, University of Halle, Halle, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Friedl
authors.affiliation: Department of Psychiatry, University of Halle, Halle, Germany.
authors.forename: Ina
authors.initials: I
authors.lastname: Giegling
authors.affiliation: Department of Psychiatry, University of Halle, Halle, Germany.
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
mesh_terms: D000328:Adult; D000483:Alleles; D058068:Endophenotypes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D020641:Polymorphism, Single Nucleotide; D013406:Suicide, Attempted / Q000523:psychology*
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
keywords: Endophenotype; Personality; Suicidal behaviour