title: Treatment of nail psoriasis with Pulse Dye Laser plus calcipotriol betametasona gel vs. Nd:YAG plus calcipotriol betamethasone gel: An intrapatient left-to-right controlled study.
abstract: BACKGROUND
  Treatment of nail psoriasis remains a challenging and often disappointing situation.
  
  
  OBJECTIVE
  To compare the efficacy, adverse reactions and tolerability of treatment of nail psoriasis with PDL vs. Nd:YAG, in association with betametasona calcipotriol gel.
  
  
  METHODS
  An open, prospective intrapatient left-to-right study was designed. The right hand of each patient received treatment with PDL and the left hand with Nd:YAG. Betamethasone calcipotriol gel was applied once a day during the first week after each laser session. A total of four sessions were administered.
  
  
  RESULTS
  The clinical efficacy was evaluated according to the NAPSI score. All patients showed improvement in nail bed and nail matrix psoriasis. The global NAPSI mean declined in 15.46 (p<0.000). There was neither statistical difference between the reduction in nail bed and matrix NAPSI nor in the treatment with PDL vs. Nd:YAG. The administration of Nd:YAG was more painful. No serious adverse effects were documented.
  
  
  CONCLUSIONS
  No random assignment and the small number of patients.
  
  
  CONCLUSIONS
  PDL and Nd:YAG have proven to be an effective treatment for nail psoriasis with no serious adverse effect. No statistically significant difference was found between the two treatments.
authors.affiliation: Servicio de Dermatología, Complejo Asistencial Universitario de Palencia, Spain. Electronic address: lauraarango9@hotmail.com.
authors.forename: L C
authors.initials: LC
authors.lastname: Arango-Duque
authors.affiliation: Servicio de Dermatología, Hospital clínico universitario de Salamanca, Salamanca, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Roncero-Riesco
authors.affiliation: Servicio de Dermatología, Hospital de Cabueñes, Gijón, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Usero Bárcena
authors.affiliation: Servicio de Dermatología, Hospital San Pedro, Logroño, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Palacios Álvarez
authors.affiliation: Servicio de Dermatología, Hospital clínico universitario de Salamanca, Salamanca, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fernández López
mesh_terms: D000328:Adult; D000368:Aged; D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D054025:Lasers, Dye; D053844:Lasers, Solid-State; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D005782:Gels; C055085:calcipotriene; D001623:Betamethasone; D002117:Calcitriol
keywords: Laser treatment; Láser de colorante pulsado; Láser, Nd:YAG; Nail psoriasis; Nd:YAG; Psoriasis ungueal; Pulse Dye Laser