title: Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility.
abstract: Gentamicin modified chitosan film (CS-GT) was produced using a three-step procedure comprising: (i) the chitosan solution was air-dried to form a chitosan (CS) film, (ii) using citric acid to generate the amide and carboxyl groups on the surface of CS, (iii) the CS with surface carboxyl groups was modified by grafting of gentamicin. After modification, this CS-GT film has excellent hydrophilicity and biocompatibility. It is very evident that the gentamicin grafting treatment significantly improves the antibacterial properties of the CS film. Our preliminary results suggest that this novel gentamicin modified chitosan film, which can be prepared in large quantities and at low cost, should have potential application in biomedical applications.
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. Electronic address: liuyang@cczu.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Peihong
authors.initials: P
authors.lastname: Ji
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Lv
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China. Electronic address: dlh@cczu.edu.cn.
authors.forename: Linhong
authors.initials: L
authors.lastname: Deng
mesh_terms: D000577:Amides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D019343:Citric Acid / Q000737:chemistry; D005839:Gentamicins / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D005839:Gentamicins; D019343:Citric Acid; D048271:Chitosan
keywords: Antibacterial property; Chitosan; Film; Gentamicin