title: Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action.
abstract: Inflammatory skin disorders that cause serious deterioration of the quality of life have become one of the major public concerns. Despite their significance, there is no fundamental cure to date. Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties which make them a promising tool for the treatment of various inflammatory diseases. Our recent preclinical and clinical studies have shown that MSCs can be successfully used for the treatment of atopic dermatitis (AD), one of the major inflammatory skin diseases. This observation along with similar reports from other groups revealed the efficacy and underlying mechanisms of MSCs in inflammatory dermatosis. In addition, it has been proposed that cell priming or gene transduction can be novel strategies for the development of next-generation high-efficacy MSCs for treating inflammatory skin diseases. We discuss here existing evidence that demonstrates the regulatory properties of MSCs on immune responses under inflammatory conditions.
authors.affiliation: Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. thshin1125@gmail.com.|Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. thshin1125@gmail.com.
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Shin
authors.affiliation: Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea. hskimcell@pusan.ac.kr.|Department of Medical Science, School of Medicine, Pusan National University, Busan 49241, Korea. hskimcell@pusan.ac.kr.
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. nomnoos@gmail.com.|Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. nomnoos@gmail.com.
authors.forename: Soon Won
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. kangpub@snu.ac.kr.|Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. kangpub@snu.ac.kr.
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Kang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D000068456:Clinical Studies as Topic; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D010641:Phenotype; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
keywords: atopic dermatitis; immunomodulation; inflammatory skin diseases; mesenchymal stem cells; psoriasis; stem cell therapy