title: Spatial distribution of resting-state BOLD regional homogeneity as a predictor of brain glucose uptake: A study in healthy aging.
abstract: Positron emission tomography using [18F]-fluorodeoxyglucose (PET-FDG) is the primary imaging modality used to measure glucose metabolism in the brain (CMRGlu). CMRGlu has been used as a biomarker of brain aging and neurodegenerative diseases, but the complexity and invasive nature of PET often limits its use in research. There is therefore great interest in developing non-invasive metrics for estimating brain CMRGlu. We therefore investigated resting state fMRI metrics such as regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF) and regional global connectivity (Closeness) with multiple analytical approaches to determine their relationship to CMRGlu. We investigated this relation in two distinct cognitively healthy populations separated by age (27 young adults and 35 older adults). Overall, we found that both regionally and across participants, ReHo strongly correlated with CMRGlu in healthy young and older adults. Moreover, ReHo demonstrated the same age-related differences as CMRGlu throughout all cortical regions, particularly in the default network and frontal areas.
authors.affiliation: Departments of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Canada. Electronic address: michael.bernier@usherbrooke.ca.
authors.forename: Michaël
authors.initials: M
authors.lastname: Bernier
authors.affiliation: Departments of Pharmacology and Physiology, Université de Sherbrooke, Canada; Research Center on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, Canada.
authors.forename: Etienne
authors.initials: E
authors.lastname: Croteau
authors.affiliation: Research Center on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, Canada.
authors.forename: Christian-Alexandre
authors.initials: CA
authors.lastname: Castellano
authors.affiliation: Departments of Medecine, Université de Sherbrooke, Canada; Departments of Pharmacology and Physiology, Université de Sherbrooke, Canada; Research Center on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, Canada.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Cunnane
authors.affiliation: Departments of Radiology, Université de Sherbrooke, Canada; CR-CHUS, Sherbrooke, Canada.
authors.forename: Kevin
authors.initials: K
authors.lastname: Whittingstall
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Aging; BOLD amplitude (ALFF); BOLD synchrony (ReHo); Glucose uptake (CMRGlu); Graph-theory