title: Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review.
abstract: Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic alterations, such as hyperandrogenism, obesity, menstrual irregularities, insulin resistance, and polycystic ovaries. The etiology remains unclear, but several genetic and environmental factors have been correlated with manifestations of this syndrome. Vitamin D plays important roles in metabolic pathways affected by PCOS, including calcium homeostasis, the insulin pathway, and sex hormone synthesis. Vitamin D concentration has been related with the severity of this disorder, and vitamin D receptor polymorphisms have been shown in some studies to have an association with some of the patterns presented by PCOS. The objective of this study is to provide an up-to-date review about vitamin D receptor polymorphisms and their association with PCOS.
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Guilherme Victor Oliveira Pimenta Dos
authors.initials: GV
authors.lastname: Reis
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Natália Alves
authors.initials: NA
authors.lastname: Gontijo
authors.affiliation: Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Kathryna Fontana
authors.initials: KF
authors.lastname: Rodrigues
authors.affiliation: Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Michelle Teodoro
authors.initials: MT
authors.lastname: Alves
authors.affiliation: Colégio Técnico (COLTEC), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Cláudia Natália
authors.initials: CN
authors.lastname: Ferreira
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.|Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Karina Braga
authors.initials: KB
authors.lastname: Gomes
mesh_terms: D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D014807:Vitamin D / Q000097:blood
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D
keywords: hyperandrogenism; insulin resistance; obesity; polycystic ovary syndrome; polymorphisms; vitamin D receptor