title: Rab10 Disruption Results in Delayed OPC Maturation.
abstract: Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development.
authors.affiliation: School of Life Sciences, Shanghai University, Shanghai, 200444, China.|Department of Neurology, Changzheng Hospital, Shanghai, 200003, China.
authors.forename: Zhao-Huan
authors.initials: ZH
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Shanghai University, Shanghai, 200444, China.
authors.forename: Wei-Qian
authors.initials: WQ
authors.lastname: Zhao
authors.affiliation: School of Life Sciences, Shanghai University, Shanghai, 200444, China.
authors.forename: Fan-Fei
authors.initials: FF
authors.lastname: Ma
authors.affiliation: School of Life Sciences, Shanghai University, Shanghai, 200444, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Shanghai University, Shanghai, 200444, China. xxhxxh@shu.edu.cn.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Xu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D000073637:Oligodendrocyte Precursor Cells / Q000473:pathology*; D009836:Oligodendroglia / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020691:rab GTP-Binding Proteins / Q000172:deficiency* / Q000235:genetics
chemical_list: C520736:Rab10 protein, mouse; D020691:rab GTP-Binding Proteins
keywords: MBP; Maturation; Membrane addition; OPC; Rab10