title: New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger.
abstract: A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém's offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50= 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL).
authors.affiliation: a Departamento de Química Orgânica e Inorgânica, Centro de Ciências , Universidade Federal do Ceará , Fortaleza , Brasil.
authors.forename: Paula Karina S
authors.initials: PKS
authors.lastname: Uchoa
authors.affiliation: a Departamento de Química Orgânica e Inorgânica, Centro de Ciências , Universidade Federal do Ceará , Fortaleza , Brasil.
authors.forename: Antonia T A
authors.initials: ATA
authors.lastname: Pimenta
authors.affiliation: b Laboratório de Ciências Químicas , Universidade Estadual do Norte Fluminense Darcy Ribeiro, FAPERJ , Campos dos Goytacazes , Brasil.|c Departamento de Química , Universidade Federal Rural do Rio de Janeiro , Seropédica-RJ , Brasil.
authors.forename: Raimundo
authors.initials: R
authors.lastname: Braz-Filho
authors.affiliation: a Departamento de Química Orgânica e Inorgânica, Centro de Ciências , Universidade Federal do Ceará , Fortaleza , Brasil.
authors.forename: Maria da Conceição F
authors.initials: MDCF
authors.lastname: de Oliveira
authors.affiliation: d Departamento de Farmácia , Universidade Federal de Sergipe , Lagarto , Brasil.
authors.forename: Natália N
authors.initials: NN
authors.lastname: Saraiva
authors.affiliation: e Departamento de Ensino , Instituto Federal de Educação Ciência e Tecnologia do Ceará - Campus Canindé , Canindé , Brasil.
authors.forename: Barbara S F
authors.initials: BSF
authors.lastname: Rodrigues
authors.affiliation: f Departamento de Fitopatologia , Universidade Federal de Lavras , Lavras , Brasil.
authors.forename: Ludwig H
authors.initials: LH
authors.lastname: Pfenning
authors.affiliation: f Departamento de Fitopatologia , Universidade Federal de Lavras , Lavras , Brasil.
authors.forename: Lucas M
authors.initials: LM
authors.lastname: Abreu
authors.affiliation: g Núcleo de Pesquisa de Desenvolvimento de Medicamentos, Departamento de Farmacologia e Fisiologia , Centro de Ciências da Saúde , Universidade Federal do Ceará , Fortaleza , Brasil.
authors.forename: Diego V
authors.initials: DV
authors.lastname: Wilke
authors.affiliation: g Núcleo de Pesquisa de Desenvolvimento de Medicamentos, Departamento de Farmacologia e Fisiologia , Centro de Ciências da Saúde , Universidade Federal do Ceará , Fortaleza , Brasil.
authors.forename: Katharine G D
authors.initials: KGD
authors.lastname: Florêncio
authors.affiliation: a Departamento de Química Orgânica e Inorgânica, Centro de Ciências , Universidade Federal do Ceará , Fortaleza , Brasil.
authors.forename: Mary Anne S
authors.initials: MAS
authors.lastname: Lima
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000737:chemistry*; D001938:Brazil; D003512:Cyclohexanones / Q000302:isolation & purification / Q000494:pharmacology; D004151:Dipeptides / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000737:chemistry; D019015:Geologic Sediments / Q000382:microbiology; D045325:HCT116 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011760:Pyrrolidinones / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003512:Cyclohexanones; D004151:Dipeptides; D004852:Epoxy Compounds; D005663:Furans; D010456:Peptides, Cyclic; D011760:Pyrrolidinones; C101438:chlovalicin; C505275:cyclo(prolyl-leucyl); C012013:pseurotin; C000608429:malformin C
keywords: Aspergillus niger; Marine-derived fungi; cytotoxic activity; furan derivative