title: Exploiting the intra-subject latency variability from single-trial event-related potentials in the P3 time range: A review and comparative evaluation of methods.
abstract: The intra-subject variability (ISV) in brain responses during cognitive processing across experimental trials has been recognised as an important facet of neural functionality reflecting an intrinsic neurophysiological characteristic of the brain. In recent decades, ISV in behaviour has been found to be significantly associated with cognitive functioning varying across individuals, development, ages, and pathological conditions. Event-related potentials (ERPs) measured in single trials are important tools for characterizing ISV at the neural level. However, due to the overlapping spectra of noise and signals, the retrieval of information from single-trial ERPs related to cognitive processing has been a challenge. We review the major problems that researchers face in the estimation of ISV in single-trial ERPs. Then, we present an extensive evaluation of several methods of single-trial latency estimation based on both simulated and real data. The relationships of ISV in ERPs and reaction times are compared between the different single-trial methods to assess their relative efficiency in predicting task performance from neural signals. The pros and cons of the methods are discussed.
authors.affiliation: Department of Psychology, Ernst-Moritz-Arndt-Universität Greifswald, 17487, Germany; Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Centre for Nonlinear Studies and The Beijing-Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems (Hong Kong), Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
authors.forename: Guang
authors.initials: G
authors.lastname: Ouyang
authors.affiliation: Department of Psychology, Ernst-Moritz-Arndt-Universität Greifswald, 17487, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Hildebrandt
authors.affiliation: Department of Psychology, Humboldt-Universität zu Berlin, D-10099 Berlin, Germany. Electronic address: werner.sommer@cms.hu-berlin.de.
authors.forename: Werner
authors.initials: W
authors.lastname: Sommer
authors.affiliation: Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Centre for Nonlinear Studies and The Beijing-Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems (Hong Kong), Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Research Centre, HKBU Institute of Research and Continuing Education,Virtual University Park Building, South Area Hi-tech Industrial Park, Shenzhen, China; Beijing Computational Science Research Center, Beijing, China. Electronic address: cszhou@hkbu.edu.hk.
authors.forename: Changsong
authors.initials: C
authors.lastname: Zhou
mesh_terms: D001921:Brain; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D006801:Humans; D011930:Reaction Time
keywords: Intra-subject variability; Method evaluation; Single-trial ERP latency estimation; Trial-to-trial latency variability