title: COMMD7 promotes hepatocellular carcinoma through regulating CXCL10.
abstract: Hepatocellular carcinoma (HCC) is still a heavy threat to public health. However, novel therapeutic and diagnostic method for HCC is still urgently needed thus far. Based on sequence analysis and homology comparison, we previously reported a novel gene termed COMMD7, which is mapped to 20q11.22 and promotes cell proliferation in HCC cells. But the molecular mechanisms underlying the pro-tumor property of COMMD7 are not fully addressed yet. In this study, we demonstrate that the conditional medium derived from COMMD7-overexpressed HCC cell promotes proliferation of naïve HCC cells. The over-expression of COMMD7 significantly induced the migratory and invasive in HCC cells. Mechanistic study found that over-expression of COMMD7 induces C-X-C motif chemokine 10 (CXCL10) expression. Blocking CXCL10 signal transduction by neutralizing antibody abolished COMMD7-mediated cell proliferation and migration. In conclusion, COMMD7 promotes hepatocellular carcinoma through regulating CXCL10. The present data suggests a potential role of CXCL10 in the oncogenic function of COMMD7, and will lead to a better understanding of the development of HCC.
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Nan
authors.initials: N
authors.lastname: You
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Na
authors.initials: N
authors.lastname: Mi
authors.affiliation: Department of Hepatobiliary Surgery, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China. Electronic address: xqyyzl1@163.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Zheng
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D054357:Chemokine CXCL10 / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D017077:Culture Media, Conditioned / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C554642:COMMD7 protein, human; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D017077:Culture Media, Conditioned
keywords: C-X-C motif chemokine 10; COMMD7; Hepatocellular carcinoma; Proliferation