title: OCT angiography of acute non-arteritic anterior ischemic optic neuropathy.
abstract: OBJECTIVE
  To describe changes of the retinal peripapillary microvasculature on optical coherence tomography angiography (OCT-A) in non-arteritic anterior ischemic optic (NAION) neuropathy.
  
  
  METHODS
  Observational study of 10 patients at the acute phase of NAION. OCT-A was performed using a 3mm×3mm square centered on the optic disc (Cirrus HD-OCT with Angioplex, Carl Zeiss Meditec, Dublin, CA). A qualitative comparison was made with the healthy fellow eye of each patient. All patients had a fluorescein angiography (HRA2, Heidelberg, Germany) and a visual field examination (Octopus 101®, Haag-Streit, USA).
  
  
  RESULTS
  In the affected eyes, OCT-A showed clear modifications in the radial peripapillary network. In all these eyes, a focal disappearance of the superficial capillary radial pattern was present, twisted and irregular. In 8 eyes, there was also a lack of vascularization in some focal areas, appearing as dark areas. No correlation was found between the topography of the vascular alteration shown on OCT-A and visual field pattern defects.
  
  
  CONCLUSIONS
  OCT-A is a new imaging technology able to demonstrate easily and safely the changes in the peripapillary capillary network during the acute phase of NAION. These changes are likely related to a decrease of the prelaminar optic nerve blood flow during the acute phase of NAION. Visual field defects are not correlated with OCT-A images, suggesting that they may be due mainly to disturbances in posterior ciliary artery blood flow.
authors.affiliation: Service d'ophtalmologie, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France; Inserm, U1219, Bordeaux Population Health Research Center, 33000 Bordeaux, France. Electronic address: marie-benedicte.rougier@chu-bordeaux.fr.
authors.forename: M-B
authors.initials: MB
authors.lastname: Rougier
authors.affiliation: Service d'ophtalmologie, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France; University Bordeaux, ISPED, 33000 Bordeaux, France; Inserm, U1219, Bordeaux Population Health Research Center, 33000 Bordeaux, France.
authors.forename: M-N
authors.initials: MN
authors.lastname: Delyfer
authors.affiliation: Service d'ophtalmologie, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France; University Bordeaux, ISPED, 33000 Bordeaux, France; Inserm, U1219, Bordeaux Population Health Research Center, 33000 Bordeaux, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Korobelnik
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000000981:diagnostic imaging; D009900:Optic Nerve / Q000000981:diagnostic imaging; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis* / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D058609:Visual Field Tests
keywords: Acute anterior ischemic optic neuropathy; Imagerie du nerf optique; Nerf optique; Neuropathie optique; Neuropathie optique ischémique antérieur aiguë; OCT angiographie; OCT angiography; Optic nerve; Optic nerve imaging; Optic neuropathy