title: Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders.
abstract: The activation or the inhibition of G-protein coupled receptors (GPCRs) implicated in the pathophysiology of neurodegenerative disorders is considered as a relevant approach for the treatment of these diseases. The modulation of the relevant GPCRs targets by positive or by negative allosteric modulators appears to be promising, the major challenge remaining the discovery of these molecules. In this review, we highlight the recent development in this field and the therapeutic potential of selected GPCRs allosteric modulators.
authors.affiliation: Addex Therapeutics, Geneva, Switzerland.
authors.forename: Robert
authors.initials: R
authors.lastname: Lütjens
authors.affiliation: Institut de Recherche Pierre Fabre, CNS Innovation Unit, Toulouse, France. Electronic address: jean.philippe.rocher@pierre-fabre.com.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Rocher
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects; D000818:Animals; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D008024:Ligands; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000503:physiopathology; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects* / Q000378:metabolism
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled