title: Chemical screening in zebrafish for novel biological and therapeutic discovery.
abstract: Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.
authors.affiliation: Stem Cell Program and Division of Hematology and Oncology, Childrens' Hospital Boston, Dana-Farber Cancer Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, United States.
authors.forename: D S
authors.initials: DS
authors.lastname: Wiley
authors.affiliation: Stem Cell Program and Division of Hematology and Oncology, Childrens' Hospital Boston, Dana-Farber Cancer Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, United States.
authors.forename: S E
authors.initials: SE
authors.lastname: Redfield
authors.affiliation: Stem Cell Program and Division of Hematology and Oncology, Childrens' Hospital Boston, Dana-Farber Cancer Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, United States.
authors.forename: L I
authors.initials: LI
authors.lastname: Zon
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004625:Embryo, Nonmammalian / Q000187:drug effects; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D054852:Small Molecule Libraries / Q000494:pharmacology; D015027:Zebrafish / Q000235:genetics / Q000254:growth & development*
chemical_list: D054852:Small Molecule Libraries
keywords: Chemical; Chemoinformatic; Hit; Libraries; Phenotype; Screen; Zebrafish