title: Motion-Robust Reconstruction based on Simultaneous Multi-Slice Registration for Diffusion-Weighted MRI of Moving Subjects.
abstract: Simultaneous multi-slice (SMS) echo-planar imaging has had a huge impact on the acceleration and routine use of diffusion-weighted MRI (DWI) in neuroimaging studies in particular the human connectome project; but also holds the potential to facilitate DWI of moving subjects, as proposed by the new technique developed in this paper. We present a novel registration-based motion tracking technique that takes advantage of the multi-plane coverage of the anatomy by simultaneously acquired slices to enable robust reconstruction of neural microstructure from SMS DWI of moving subjects. Our technique constitutes three main components: 1) motion tracking and estimation using SMS registration, 2) detection and rejection of intra-slice motion, and 3) robust reconstruction. Quantitative results from 14 volunteer subject experiments and the analysis of motion-corrupted SMS DWI of 6 children indicate robust reconstruction in the presence of continuous motion and the potential to extend the use of SMS DWI in very challenging populations.
authors.affiliation: Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Bahram
authors.initials: B
authors.lastname: Marami
authors.affiliation: Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Benoit
authors.initials: B
authors.lastname: Scherrer
authors.affiliation: Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Onur
authors.initials: O
authors.lastname: Afacan
authors.affiliation: Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Simon K
authors.initials: SK
authors.lastname: Warfield
authors.affiliation: Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Gholipour
mesh_terms: D000293:Adolescent; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D000075530:Organ Motion; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors
keywords: Diffusion-weighted; MRI; Motion; Simultaneous multi-slice