title: [Oral antidiabetic drugs in treatment of type 1 diabetes mellitus].
abstract: Review article summarizes current knowledge of the use of oral antidiabetics (approved for treatment of type 2 diabetes) in type 1 diabetic patients. Following drugs were tested: metformin, gliptines, analogues of GLP-1, glitazones, inhibitors of α-glukozidase and gliflozines. The latter seem to be the most perspective ones, however, more studies are warranted for definitive confirmation of their efficacy and safety. Current evidence-based results did not clearly show efficacy and safety of oral antidiabetics as adjuvant treatment in type 1 diabetic patients and thus, they still represent off-label treatment in this type of diabetes.Key words: oral antidiabetics - type 1 diabetes mellitus.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Brunerová
authors.forename: Jan
authors.initials: J
authors.lastname: Brož
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000517:prevention & control; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use; D052216:Glucagon-Like Peptide 1 / Q000031:analogs & derivatives; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D052216:Glucagon-Like Peptide 1; D008687:Metformin