title: Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029T.
abstract: Two new aminocyclitol amide derivatives, nabscessins A (1) and B (2), were isolated from the culture broth of a pathogenic actinomycete species, Nocardia abscessus IFM 10029T. The structures of nabscessins A and B were elucidated by spectral studies, and the compounds showed antifungal activity against Cryptococcus neoformans, with IC50values of 32 and 16 μg/mL, respectively.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Hara
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishikawa
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hara
authors.affiliation: Graduate School of Integrated Arts and Sciences, Hiroshima University , 1-7-1 Kagamiyama, Higashi-hiroshima, 739-8521, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nehira
authors.affiliation: Medical Mycology Research Center, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Medical Mycology Research Center, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
authors.forename: Masami
authors.identifier: 0000-0002-2839-1045
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D039903:Actinobacteria / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects; D054812:Cyclitols / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry*; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D054812:Cyclitols; D012336:RNA, Ribosomal, 16S; C000620998:nabscessin A; C000620999:nabscessin B