title: Relationship of Serum Betatrophin with Nonalcoholic Fatty Liver in a Chinese Population.
abstract: OBJECTIVE
  This study aimed to investigate the association of serum betatrophin with the status and progression of nonalcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  A total of 249 subjects who received ultrasonic examination of liver fat content (LFC) were recruited. Anthropometric and biochemical examinations were performed. Serum betatrophin was measured by ELISA.
  
  
  RESULTS
  Compared with control group, serum betatrophin significantly increased in NAFLD group (P < 0.05). There was significant difference in serum betatrophin among control, low liver fat content (LLFC), and high liver fat content (HLFC) groups (P < 0.01). After adjustment for gender, age, BMI, FPG and HbA1c, the betatrophin positively correlated with LFC (r = 0.185, P < 0.01) and TG (r = 0.195, P < 0.01). Stepwise multiple regression analysis indicated serum betatrophin was independently related to LFC (P < 0.05). Multivariate logistic regression analysis revealed subjects in the highest tertile of serum betatrophin had higher odds of having NAFLD after adjustment for traditional NAFLD risk factors (OR = 2.88, 95%CI: 1.15-7.19) (P<0.05).
  
  
  CONCLUSIONS
  Serum betatrophin is an independent risk factor for NAFLD and potential non-invasive marker for its progression. Serum betatrophin may be helpful for the early diagnosis of NAFLD and improvement of its prognosis.
authors.affiliation: Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical College, and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical College, and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Shao
authors.affiliation: Department of Geriatrics, Huai'an Hospital Affiliated to Xuzhou Medical College, and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
authors.forename: Dianxuan
authors.initials: D
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical College, and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Hao
authors.affiliation: Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical College, and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Yingyun
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Hongwen
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Color Doppler Ultrasound, Huai'an Hospital Affiliated to Xuzhou Medical College, and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical College, and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
authors.forename: Weinan
authors.initials: W
authors.lastname: Yu
mesh_terms: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D018450:Disease Progression; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology / Q000473:pathology; D036361:Peptide Hormones / Q000097:blood*; D012307:Risk Factors
chemical_list: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D036361:Peptide Hormones; C576683:ANGPTL8 protein, human; C517652:hemoglobin A1c protein, human