title: Evaluation of Long-Term Toxicity of Oral Zinc Oxide Nanoparticles and Zinc Sulfate in Mice.
abstract: The toxicological effects of zinc oxide nanoparticles (nano-ZnOs) are related to their dissolution and interference with zinc ion homeostasis. High-soluble zinc sources may produce more severe and acute toxicity; however, the evaluation of potential toxicity of long-term exposure to nano-ZnOs and high-soluble sources of zinc remains obscure. This study aimed at evaluating effects of nano-ZnOs and zinc sulfate on development, serum and hematological parameters, and mineral concentrations in selected tissues and intestinal microbiota in mice via gastrointestinal administration for 7 weeks. Results indicated that 250 mg/kg nano-ZnOs reduced the body weight from weeks 8 to 11, increased serum glutamic-pyruvic transaminase activity, and increased the zinc concentrations of the serum, liver, and kidney while did not affect the relative organ weight, intestinal microbiota, and other mineral concentrations (Fe, Cu, and Mn) in the kidney, liver, and thigh muscle. Oral administration with 250 mg/kg zinc sulfate seemed to show more severe and acute toxicity since mice in zinc sulfate group exhibited reduced body weight from weeks 5 to 11, decreased relative pancreas weight, and increased serum glutamic-oxalacetic transaminase activity and intestinal enteric group.
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Cheng
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhou
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Jintian
authors.initials: J
authors.lastname: He
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Zheng
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhong
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China. tianwangnjau@163.com.
authors.forename: Tian
authors.initials: T
authors.lastname: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008670:Metals / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D018482:Muscle, Skeletal / Q000378:metabolism*; D053758:Nanoparticles / Q000009:adverse effects*; D013997:Time Factors; D019287:Zinc Sulfate / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D008670:Metals; D019287:Zinc Sulfate
keywords: Development toxicity; Microbiota; Mineral concentration; Zinc oxide nanoparticle; Zinc sulfate