title: Molecular and Functional Diagnostic Tools in Precision Oncology for Urological Malignancies.
abstract: Urological malignancies, represented mainly by prostate, bladder, and renal cancers, are some of the leading causes of cancer-related mortalities worldwide. Despite various efforts over decades to develop early detection tests and effective therapeutic paradigms, the response rate to the existing treatments remains low for both primary and late stage/recurrent phases of these cancers. The evolving landscape of molecular diagnostics, aiming to make the diagnosis and treatment more patient-driven, underpins precision oncology and particularly intends to rationally profile individual tumors and highlight the mechanistic insight and complexity of tumor microenvironment in order to develop biomarkers of toxicity risks and response prediction in a clinically oriented dynamical setting. The present review is an effort to capture some of the recent developments in the area of molecular diagnostics and functional testing platforms and their potential application in clinical decision making in the premises of precision oncology of urological malignancies.
authors.affiliation: Department of Cancer Biology, Mitra Biotech, 202, Narayana Nethralaya, Health City, Hosur Main Road, Bangalore, 560099 India.
authors.forename: Vasanthakumar
authors.initials: V
authors.lastname: Sekar
authors.affiliation: Department of Molecular Pathology, Mitra Biotech, 202, Narayana Nethralaya, Health City, Hosur Main Road, Bangalore, 560099 India.
authors.forename: Debapriya Ghosh
authors.initials: DG
authors.lastname: Mehrotra
authors.affiliation: Department of Molecular Pathology, Mitra Biotech, 202, Narayana Nethralaya, Health City, Hosur Main Road, Bangalore, 560099 India.
authors.forename: Biswanath
authors.initials: B
authors.lastname: Majumder
keywords: Ex vivo models; Precision therapy; Prediction biomarkers; Urological cancer