title: Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii.
abstract: Four new indolediketopiperazine derivatives (1-4), along with nine known congeners (5-13), were isolated and identified from the culture extract ofEurotium cristatumEN-220, an endophytic fungus obtained from the marine algaSargassum thunbergii. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds1-4were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in5of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (Artemia salina) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.
authors.affiliation: Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China. fooddfy@126.com.|College of Chemistry and Pharmacy, Qingdao Agricultural University, Changcheng Road 700, Qingdao 266109, China. fooddfy@126.com.
authors.forename: Feng-Yu
authors.initials: FY
authors.lastname: Du
authors.affiliation: Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China. lixin871014@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China. lixmqd@aliyun.com.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.affiliation: College of Chemistry and Pharmacy, Qingdao Agricultural University, Changcheng Road 700, Qingdao 266109, China. qauliwei@163.com.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Zhu
authors.affiliation: Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China. wangbg@ms.qdio.ac.cn.
authors.forename: Bin-Gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry / Q000382:microbiology; D001156:Artemia / Q000187:drug effects; D002942:Circular Dichroism / Q000379:methods; D055325:Eurotium / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D008826:Microbial Sensitivity Tests / Q000379:methods; D044647:Sargassum / Q000737:chemistry* / Q000382:microbiology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000975:Antioxidants
keywords: Eurotium cristatum; bioactivity; endophytic fungus; indolediketopiperazine; marine alga