title: [Severe neutropenia during treatment with amoxicillin/clavulanic acid in a patient on regular hemodialysis treatment].
abstract: Beta-lactams are one of the most widely used antibiotics in respiratory diseases, both in adults and in the pediatric population. Their widespread use is also linked to the elevated tolerability and low risk of side effects that are generally not severe. We present here the case of a patient on regular haemodialysis pertaining to our Center who, after a seven-day treatment period with amoxicillin/clavulanic acid antibiotic therapy (medication originator), developed a framework of severe neutropenia (neutrophils till 10/mmc) resulting in hospitalization and the beginning of a specific diagnostic and therapeutic work-up. Our case is characterised, differently from other reports in the literature, for the onset of neutropenia after a short course of antibiotics, with a drug already used in the past without any side effects. During hospitalization, use of immunostimulant therapy led to the rapid recovery of a normal white blood cell count and resolution of severe neutropenia.
authors.forename: Nicola
authors.initials: N
authors.lastname: Spetrino
authors.forename: Marta
authors.initials: M
authors.lastname: Arazzi
authors.forename: Giorgia
authors.initials: G
authors.lastname: Di Fulvio
authors.forename: Federica
authors.initials: F
authors.lastname: Giunta
authors.forename: Xhensila
authors.initials: X
authors.lastname: Grabocka
authors.forename: Maria Olimpia
authors.initials: MO
authors.lastname: Longo
authors.forename: Gabriella
authors.initials: G
authors.lastname: Micioni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pezzutto
authors.forename: Simona
authors.initials: S
authors.lastname: Silvestri
authors.forename: Marco
authors.initials: M
authors.lastname: Tondo
authors.forename: Giacinta
authors.initials: G
authors.lastname: Vigilante
authors.forename: Mario
authors.initials: M
authors.lastname: Bonomini
mesh_terms: D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*; D006435:Renal Dialysis; D012720:Severity of Illness Index; D065093:beta-Lactamase Inhibitors / Q000009:adverse effects*
chemical_list: D065093:beta-Lactamase Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination