title: Co-delivery of docetaxel and curcumin prodrug via dual-targeted nanoparticles with synergistic antitumor activity against prostate cancer.
abstract: OBJECTIVE
  Combination therapy is increasingly used as a primary cancer treatment regimen. In this report, we designed EGFR peptide decorated nanoparticles (NPs) to co-deliver docetaxel (DTX) and pH sensitive curcumin (CUR) prodrug for the treatment of prostate cancer.
  
  
  RESULTS
  EGFR peptide (GE11) targeted, pH sensitive, DTX and CUR prodrug NPs (GE11-DTX-CUR NPs) had an average diameter of 167nm and a zeta potential of -37.5mV. The particle size of the NPs was adequately maintained in serum and a sustained drug release pattern was observed. Improved inhibition of cancer cell and tumor tissue growth was shown in the GE11-DTX-CUR NPs group compared to the other groups.
  
  
  CONCLUSIONS
  It can be summarized that DTX and CUR prodrug could be delivered into tumor cells simultaneously by the GE 11 targeting and the EPR effect of NPs. The resulting GE11-DTX-CUR NPs is a promising system for the synergistic antitumor treatment of prostate cancer.
authors.affiliation: Department of Renal Transplantation, The Second Hospital of Shandong University, Ji'nan 250033, Shandong, PR China.
authors.forename: Jieke
authors.initials: J
authors.lastname: Yan
authors.affiliation: Clinical Department, Jinan Vocation College of Nursing, Ji'nan 250102, Shandong, PR China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Research Department, The Second Hospital of Shandong University, Ji'nan 250033, Shandong, PR China.
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Renal Transplantation, The Second Hospital of Shandong University, Ji'nan 250033, Shandong, PR China.
authors.forename: Shuangde
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Renal Transplantation, The Second Hospital of Shandong University, Ji'nan 250033, Shandong, PR China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Tian
authors.affiliation: Department of Renal Transplantation, The Second Hospital of Shandong University, Ji'nan 250033, Shandong, PR China.
authors.forename: Wengu
authors.initials: W
authors.lastname: Pan
authors.affiliation: Department of Renal Transplantation, The Second Hospital of Shandong University, Ji'nan 250033, Shandong, PR China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Renal Transplantation, The Second Hospital of Shandong University, Ji'nan 250033, Shandong, PR China. Electronic address: wanghongweisdu@163.com.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
mesh_terms: D000156:Aconitic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000077143:Docetaxel; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D004357:Drug Synergism; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011355:Prodrugs / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D066244:Proton Magnetic Resonance Spectroscopy; D043823:Taxoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; C572557:GE11 peptide; D010455:Peptides; D011355:Prodrugs; D043823:Taxoids; D013844:Thiazoles; C517282:coumarin 6; D000077143:Docetaxel; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; C064873:aconitic anhydride; D000156:Aconitic Acid; D003474:Curcumin
keywords: Dual-targeted nanoparticles; EGFR-mediated endocytosis; Prostate cancer; Synergistic combination therapy; Targeted delivery system