title: The role of renal sympathetic nerves in ischemia reperfusion injury.
abstract: Decreased blood flow supply to the kidneys known as renal ischemia/reperfusion is a common occurrence during various clinical and surgical settings. This remains highly concerning as it is a major cause of acute kidney injury (AKI). The kidneys have a rich supply of efferent and afferent sympathetic nerves playing a crucial physiological role in regulation of renal function. Studies in animal models of renal ischemia/reperfusion injury have indicated that very early during an ischemic event, the sympathetic nerves are activated and in concert with decreased nitric oxide availability, increased angiotensin II and several other molecules results in renal damage. Renal sympathetic inhibition or denervation seems to prevent or decrease some of the renal damage induced by ischemia/reperfusion injury but the evidence at present is based on animal studies and remains to be confirmed in the clinical setting. Remote ischemic preconditioning (IPC) has gained a lot of interest as a strategy to limit ischemia/reperfusion damage with some recent evidence suggesting that intact sympathetic nerves may be relevant in mediating protective effects. In this article, we review the experimental studies and emerging clinical studies that have investigated the role of sympathetic nerves following ischemia/reperfusion injury and studies exploring the role of sympathetic nerves in IPC and preventing tissue dysfunction induced by renal ischemia/reperfusion.
authors.affiliation: Faculty of Health, Arts and Design, Iverson Health Innovations Research Centre, Swinburne University of Technology, Hawthorn, PO Box 218, Victoria 3122, Australia; Human Neuro-transmitters and Neurovascular Hypertension & Kidney Disease Laboratories, Baker IDI Heart & Diabetes Institute, Melbourne, Australia; Department of Physiology, Monash University, Clayton, Australia. Electronic address: elisabeth.lambert@bakeridi.edu.au.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Lambert
authors.affiliation: Human Neuro-transmitters and Neurovascular Hypertension & Kidney Disease Laboratories, Baker IDI Heart & Diabetes Institute, Melbourne, Australia; School of Medicine and Pharmacology, Royal Perth Hospital Unit, Faculty of Medicine, Dentistry & Health Sciences, University of Western Australia, Australia. Electronic address: markus.schlaich@uwa.edu.au.
authors.forename: Markus
authors.initials: M
authors.lastname: Schlaich
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology*; D015427:Reperfusion Injury / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*