title: Heterogeneous propagation of spreading depolarizations in the lissencephalic and gyrencephalic brain.
abstract: In the recently published article, "Heterogeneous incidence and propagation of spreading depolarizations," it is shown, in vivo and in vitro, how KCl-induced spreading depolarizations in mouse and rat brains can be highly variable, and that they are not limited, as once thought, to a concentric, isotropic, or homogenous depolarization wave in space or in time. The reported results serve as a link between the different species, and this paper contributes to changing the way in which SD expansion is viewed in the lissencephalic brain. Here, we discuss their results with our previous observations made in the gyrencephalic swine brain, in computer simulations, and in the human brain.
authors.affiliation: 1 Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Edgar
authors.initials: E
authors.lastname: Santos
authors.affiliation: 1 Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Renán
authors.initials: R
authors.lastname: Sánchez-Porras
authors.affiliation: 1 Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.|2 Department of Neurosurgery, Klinikum Ludwigsburg, Ludwigsburg, Germany.
authors.forename: Oliver W
authors.initials: OW
authors.lastname: Sakowitz
authors.affiliation: 3 Center for Stroke Research Berlin, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: Jens P
authors.initials: JP
authors.lastname: Dreier
authors.affiliation: 4 Department of Physics, Humboldt University of Berlin, Berlin, Germany.
authors.forename: Markus A
authors.initials: MA
authors.lastname: Dahlem
mesh_terms: D000818:Animals; D001921:Brain; D013181:Cortical Spreading Depression; D006801:Humans; D051379:Mice; D013552:Swine
keywords: Spreading depolarization; animal models; gyrencephalic brain; intrinsic optical signal imaging; lissencephalic brain