title: Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis.
abstract: Acetyl-CoA has diverse fates in metabolism and can be derived from a variety of nutrients. In a recent study published in Nature, Wong et al. (2016) show that endothelial cells oxidize fatty acids to produce acetyl-CoA for epigenetic modifications critical to lymphangiogenesis.
authors.affiliation: Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Hosios
authors.affiliation: Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: mvh@mit.edu.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Vander Heiden
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D042583:Lymphangiogenesis; D010084:Oxidation-Reduction
chemical_list: D005227:Fatty Acids; D000105:Acetyl Coenzyme A