title: Gastric vascular and motor responses to anaphylactic hypotension in anesthetized rats, in comparison to those with hemorrhagic or vasodilator-induced hypotension.
abstract: Anaphylactic shock is life-threatening, but pathophysiology of the stomach lesion remains unclear. We determined gastric hemodynamics and gastric functions during anaphylactic hypotension, as compared to hypotension induced by hemorrhage or sodium nitroprusside (SNP) in anesthetized and ovalbumin-sensitized Sprague-Dawley rats. Systemic arterial pressure, portal venous pressure, and gastric arterial blood flow were measured, and gastric vascular resistance (GVR) was determined. Separately, the intragastric pressure (IGP) and gastric effluent, as a measure of gastric flux, were continuously measured. During anaphylaxis, GVR decreased only transiently at 0.5 min, followed by an increase. IGP increased markedly, while gastric flux decreased. During hemorrhage, GVR and IGP increased, while gastric flux did not change. When SNP was injected, both GVR and IGP decreased and gastric flux increased only just after injection. In conclusion, gastric vasodilatation occurs only transiently after antigen injection, and gastric motility increases, but gastric emptying deceases during anaphylactic hypotension in anesthetized rats.
authors.affiliation: Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan.
authors.forename: Yuhichi
authors.initials: Y
authors.lastname: Kuda
authors.affiliation: Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan. shibamo@kanazawa-med.ac.jp.
authors.forename: Toshishige
authors.initials: T
authors.lastname: Shibamoto
authors.affiliation: Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan.|Department of Colorectal and Hernia Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan.|Department of Infectious Disease, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanida
authors.affiliation: Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kurata
mesh_terms: D000707:Anaphylaxis / Q000503:physiopathology*; D000758:Anesthesia / Q000379:methods; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects / Q000502:physiology; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006470:Hemorrhage / Q000188:drug therapy / Q000503:physiopathology*; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology*; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D010047:Ovalbumin / Q000494:pharmacology; D017082:Portal Pressure / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D009599:Nitroprusside; D010047:Ovalbumin
keywords: Anaphylactic shock; Anesthetized rats; Gastric circulation; Gastric emptying; Gastric motility; Hemorrhage