title: Inhibition of Propionibacterium acnes lipase activity by the antifungal agent ketoconazole.
abstract: The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits P. acnes lipase activity. We previously showed that the drug also inhibits the growth of P. acnes. Thus, ketoconazole may serve as an alternative treatment for acne vulgaris, which is important because the number of antibiotic-resistant P. acnes strains has been increasing.
authors.affiliation: Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Unno
authors.affiliation: Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
authors.forename: Otomi
authors.initials: O
authors.lastname: Cho
authors.affiliation: Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000382:microbiology; D000935:Antifungal Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000201:enzymology*
chemical_list: D000935:Antifungal Agents; D008049:Lipase; D007654:Ketoconazole
keywords: Propionibacterium acnes; ketoconazole; lipase