title: A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo.
authors.affiliation: School of Pharmaceutical Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang
authors.affiliation: School of Pharmaceutical Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Mei
authors.affiliation: Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Xiurui
authors.initials: X
authors.lastname: Zhu
authors.affiliation: School of Pharmaceutical Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zu
authors.affiliation: School of Pharmaceutical Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Tian
authors.affiliation: School of Pharmaceutical Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
authors.forename: Qiannan
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Dong
authors.affiliation: School of Pharmaceutical Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Tan
mesh_terms: D000818:Animals; D001483:Base Sequence; D000076987:CRISPR-Associated Protein 9 / Q000378:metabolism*; D064113:CRISPR-Cas Systems / Q000235:genetics*; D004279:DNA, Viral / Q000378:metabolism*; D018390:Gene Targeting; D057809:HEK293 Cells; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry; D000071449:Proprotein Convertase 9 / Q000378:metabolism*
chemical_list: D004279:DNA, Viral; D008055:Lipids; D000076987:CRISPR-Associated Protein 9; D000071449:Proprotein Convertase 9