title: The Human Stomach in Health and Disease: Infection Strategies by Helicobacter pylori.
abstract: Helicobacter pylori is a bacterial pathogen which commonly colonizes the human gastric mucosa from early childhood and persists throughout life. In the vast majority of cases, the infection is asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer, however, and these outcomes occur in 10-15% of those infected. Gastric adenocarcinoma is the third most common cause of cancer-associated death, and peptic ulcer disease is a significant cause of morbidity. Disease risk is related to the interplay of numerous bacterial host and environmental factors, many of which influence chronic inflammation and damage to the gastric mucosa. This chapter summarizes what is known about health and disease in H. pylori infection, and highlights the need for additional research in this area.
authors.affiliation: NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the Nottingham Digestive Diseases Centre, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK. Karen.robinson@nottingham.ac.uk.
authors.forename: Karen
authors.initials: K
authors.lastname: Robinson
authors.affiliation: NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the Nottingham Digestive Diseases Centre, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.
authors.forename: Darren P
authors.initials: DP
authors.lastname: Letley
authors.affiliation: NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the Nottingham Digestive Diseases Centre, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000502:physiology*; D006801:Humans; D013270:Stomach / Q000276:immunology / Q000382:microbiology*; D013274:Stomach Neoplasms / Q000276:immunology / Q000382:microbiology; D013276:Stomach Ulcer / Q000276:immunology / Q000382:microbiology
keywords: Gastric cancer; Helicobacter pylori; Inflammation; Mucosal immunity; Peptic ulcer disease