title: Routes to Diagnosis for Suspected Sarcoma: The Impact of Symptoms and Clinical Findings on the Diagnostic Process.
abstract: Background and Objectives. Sarcoma patients often experience delay before diagnosis. We examined the association between presenting symptoms/signs and time intervals for suspected sarcoma patients.Methods. 545 consecutive patients suspected for sarcoma referred over a one-year period were included. Median time intervals in routes to diagnosis were collected from medical records and questionnaires.Results. 102 patients (18.7%) had a sarcoma; 68 (12.5%) had other malignancies. Median interval for the patient (time from first symptom to first doctor visit), primary care, local hospital, sarcoma center, diagnostic, and total interval for sarcoma patients were 77, 17, 29, 17, 65, and 176 days, respectively. Sarcoma patients visited more hospital departments and had longer median primary care (+10 days) and diagnostic intervals (+19 days) than patients with benign conditions. Median primary care (-19 days) and sarcoma center (-4 days) intervals were shorter for patients with a lump versus no lump. Median patient (+40 days), primary care (+12 days), diagnostic (+17 days), and total intervals (+78 days) were longer for patients presenting with pain versus no pain. GP suspicion of malignancy shortened local hospital (-20 days) and total intervals (-104 days).Conclusions. The main part of delay could be attributed to the patient and local hospitals. Length of time intervals was associated with presenting symptoms/signs and GP suspicion.
authors.affiliation: Sarcoma Center of Aarhus University Hospital, Aarhus C, Denmark; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark.
authors.forename: Heidi
authors.identifier: 0000-0002-3901-2688
authors.initials: H
authors.lastname: Buvarp Dyrop
authors.affiliation: The Research Unit for General Practice, Research Center for Cancer Diagnosis, Aarhus University, Aarhus C, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Vedsted
authors.affiliation: Sarcoma Center of Aarhus University Hospital, Aarhus C, Denmark; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark.
authors.forename: Mathias
authors.initials: M
authors.lastname: Rædkjær
authors.affiliation: Department of Oncology, Sarcoma Center of Aarhus University Hospital, Aarhus C, Denmark.
authors.forename: Akmal
authors.identifier: 0000-0002-6020-2320
authors.initials: A
authors.lastname: Safwat
authors.affiliation: Department of Orthopedics, Sarcoma Center of Aarhus University Hospital, Aarhus C, Denmark.
authors.forename: Johnny
authors.identifier: 0000-0003-2092-5425
authors.initials: J
authors.lastname: Keller