title: miR-200b-3p in plasma is a potential diagnostic biomarker in oral squamous cell carcinoma.
abstract: BACKGROUND
  Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour.
  
  
  OBJECTIVE
  Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls.
  
  
  RESULTS
  Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade. The AUC of miR-200b-3p for OSCC was 0.9173. miR-200b-3p was significantly downregulated after surgery. High miR-200b-3p expression was associated with poor prognosis.
  
  
  CONCLUSIONS
  Plasma miR-200b-3p could be a potential diagnostic biomarker for OSCC.
authors.affiliation: a Department of Neurosurgery , The Forth Affiliated Hospital of Nantong Medical College , Yancheng , Jiangsu , China.|b Department of Ear-Nose-Throat , The Second People's Hospital of Huai'An , Jiangsu , China.
authors.forename: Guan
authors.initials: G
authors.lastname: Sun
authors.affiliation: b Department of Ear-Nose-Throat , The Second People's Hospital of Huai'An , Jiangsu , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cao
authors.affiliation: c Department of Ear-Nose-Throat , The Second People's Hospital of Taizhou , Taizhou , Jiangsu , China.
authors.forename: Peibei
authors.initials: P
authors.lastname: Wang
authors.affiliation: b Department of Ear-Nose-Throat , The Second People's Hospital of Huai'An , Jiangsu , China.
authors.forename: Hongmao
authors.initials: H
authors.lastname: Song
authors.affiliation: b Department of Ear-Nose-Throat , The Second People's Hospital of Huai'An , Jiangsu , China.
authors.forename: Tongwu
authors.initials: T
authors.lastname: Bie
authors.affiliation: d Department of Neurosurgery , The Affiliated Jiangning Hospital of Nanjing Medical University , Nanjing , Jiangsu , China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: b Department of Ear-Nose-Throat , The Second People's Hospital of Huai'An , Jiangsu , China.
authors.forename: De
authors.lastname: Huai
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D015999:Multivariate Analysis; D011379:Prognosis; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C533896:MIRN200 microRNA, human; D035683:MicroRNAs
keywords: diagnosis; miR-200b-3p; oral squamous cell carcinoma; prognosis