title: Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines.
abstract: Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network's screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients.
authors.affiliation: Department of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR USA ; University of Puerto Rico Medical Sciences Campus, School of Medicine, San Juan, PR USA ; University of Puerto Rico Comprehensive Cancer Center, PMB711 Ave. De Diego 89 Ste. 105, San Juan, PR 00927-6346 USA.
authors.forename: Marcia
authors.initials: M
authors.lastname: Cruz-Correa
authors.affiliation: Department of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR USA ; University of Puerto Rico Medical Sciences Campus, School of Medicine, San Juan, PR USA.
authors.forename: Julyann
authors.initials: J
authors.lastname: Pérez-Mayoral
authors.affiliation: Ponce Health Sciences University, Ponce Research Institute, Ponce, PR USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Dutil
authors.affiliation: Cancer Center, Auxilio Mutuo Hospital, San Juan, PR USA.
authors.forename: Miguel
authors.initials: M
authors.lastname: Echenique
authors.affiliation: Puerto Rico Gastroenterology Association, San Juan, PR USA.
authors.forename: Rafael
authors.initials: R
authors.lastname: Mosquera
authors.affiliation: Department of Pediatrics, University of Puerto Rico School of Medicine, San Juan, PR USA.
authors.forename: Keila
authors.initials: K
authors.lastname: Rivera-Román
authors.affiliation: Department of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR USA.
authors.forename: Sharee
authors.initials: S
authors.lastname: Umpierre
authors.affiliation: Department of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR USA.
authors.forename: Segundo
authors.initials: S
authors.lastname: Rodriguez-Quilichini
authors.affiliation: Department of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR USA ; University of Puerto Rico Medical Sciences Campus, School of Medicine, San Juan, PR USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Gonzalez-Pons
authors.affiliation: Department of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR USA ; University of Puerto Rico Medical Sciences Campus, School of Medicine, San Juan, PR USA.
authors.forename: Myrta I
authors.initials: MI
authors.lastname: Olivera
authors.affiliation: Department of Pathology, University of Puerto Rico School of Medicine, San Juan, PR USA.
authors.forename: Sherly
authors.initials: S
authors.lastname: Pardo
keywords: Genetic counseling; Genetic testing; Germline mutations; Hereditary cancer; Hispanics