title: The relationship between fragmented QRS and functional significance of coronary lesions.
abstract: Recently fragmented QRS (fQRS) on electrocardiography (ECG) has been introduced as a predictor of myocardial scarring and myocardial ischemia in coronary artery disease (CAD).
  
  
  
  The aim of this study was to investigate the relationship between fQRS and fractional flow reserve (FFR) results in patients with the intermediate degree of coronary artery stenosis.
  
  
  
  A total of 301 consecutive patients who underwent coronary angiography (CAG) and FFR measurement for intermediate coronary artery stenosis were included in the study. The study patients were divided into two groups: the low FFR group (FFR value of ≤0.80) and normal FFR (FFR value of >0.80) group. Both groups were compared in terms of the presence of fQRS.
  
  
  
  Of 301 patients, fQRS was detected in 128 (42.5%) and low FFR was detected in 115 (38.2%). In the low FFR group, fQRS was significantly higher (P<0.001). Multivariate analysis showed that fQRS was an independent predictor of myocardial ischemia in patients with intermediate coronary stenosis (OR=7.202, CI 95%, 4.195-12.367; p<0.001). The presence of fQRS had 70% sensitivity and 74% specificity for the prediction of FFR≤0.80.
  
  
  
  In clinical practice, the presence of fQRS on ECG is associated with myocardial ischemia in patients with intermediate coronary stenosis.
authors.affiliation: Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Korkmaz
authors.affiliation: Bezmialem Vakif University Hospital, Department of Cardiology, Istanbul, Turkey. Electronic address: drakadiryildiz@gmail.com.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Mevlut
authors.initials: M
authors.lastname: Demir
authors.affiliation: Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Ozyazgan
authors.affiliation: Atatürk Pulmonary Disease and Thorasic Surgery Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Sahan
authors.affiliation: Turkey Yuksek Ihtisas Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Acar
authors.affiliation: Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Guray
authors.affiliation: Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ileri
authors.affiliation: Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Ozgul Ucar
authors.initials: OU
authors.lastname: Elalmis
mesh_terms: D023921:Coronary Stenosis / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Coronary artery stenosis; Fractional flow reserve; Fragmented QRS; Ischemia