title: Response surface methodology: A non-conventional statistical tool to maximize the throughput of Streptomyces species biomass and their bioactive metabolites.
abstract: Among diverse actinobacteria, Streptomyces is a renowned ongoing source for the production of a large number of secondary metabolites, furnishing immeasurable pharmacological and biological activities. Hence, to meet the demand of new lead compounds for human and animal use, research is constantly targeting the bioprospecting of Streptomyces. Optimization of media components and physicochemical parameters is a plausible approach for the exploration of intensified production of novel as well as existing bioactive metabolites from various microbes, which is usually achieved by a range of classical techniques including one factor at a time (OFAT). However, the major drawbacks of conventional optimization methods have directed the use of statistical optimization approaches in fermentation process development. Response surface methodology (RSM) is one of the empirical techniques extensively used for modeling, optimization and analysis of fermentation processes. To date, several researchers have implemented RSM in different bioprocess optimization accountable for the production of assorted natural substances from Streptomyces in which the results are very promising. This review summarizes some of the recent RSM adopted studies for the enhanced production of antibiotics, enzymes and probiotics using Streptomyces with the intention to highlight the significance of Streptomyces as well as RSM to the research community and industries.
authors.affiliation: a Bioprocess Technology Laboratory, Department of Microbiology , School of Life Sciences, Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.
authors.forename: Selvanathan
authors.initials: S
authors.lastname: Latha
authors.affiliation: a Bioprocess Technology Laboratory, Department of Microbiology , School of Life Sciences, Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.
authors.forename: Govindhan
authors.initials: G
authors.lastname: Sivaranjani
authors.affiliation: a Bioprocess Technology Laboratory, Department of Microbiology , School of Life Sciences, Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.|b Department of Molecular, Cellular and Biomedical Sciences , University of New Hampshire , Durham , USA.
authors.forename: Dharumadurai
authors.initials: D
authors.lastname: Dhanasekaran
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001688:Biological Products / Q000378:metabolism*; D018533:Biomass; D003627:Data Interpretation, Statistical; D055808:Drug Discovery / Q000379:methods; D005285:Fermentation / Q000502:physiology*; D019936:Probiotics / Q000378:metabolism; D064210:Secondary Metabolism / Q000502:physiology*; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products
keywords: Streptomyces; bioactive metabolites; bioprocess optimization; response surface methodology; yield improvement