title: Predictive role of Trimprob associated with multiparametric MRI in the diagnosis of prostate cancer.
abstract: OBJECTIVE
  To evaluate the predictive value of TRIMprob test to detect prostate cancer (PCa) in patients referred to prostate biopsy (PB).
  
  
  METHODS
  Patients with PSA <10ng/mL and rectal exam without findings suggestive of prostate cancer were selected for TRIMprob evaluation. Exam was performed by a single operator through transperineal approach. Patients admitted for the study were submitted to TRIMprob and multiparametric magnetic resonance (mpMRI) and posteriorly to PB.
  
  
  RESULTS
  In total, 77 patients were included. TRIMprob showed evidences of PCa in 25 (32.5%) and was negative in 52 patients (67.5%). The rate of detection of prostate cancer at biopsy was higher in patients with positive TRIMprob (16/25; 64.0%) than in patients with negative TRIMprob (11/52; 21.1%; p<0.001). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of TRIMprob were respectively 61.5%, 82.0%, 64.0%, 80.3% and 74.0%. ROC curve showed the following areas under the curve values for TRIMprob, mpMRI and combination of TRIMprob + mpMRI: 0.706; 0.662 and 0.741 respectively. At combined analysis, when both TRIMprob and mpMRI were negative for prostate cancer, accuracy was 96.3% or only 1 in 27 PB was positive (3.7%).
  
  
  CONCLUSIONS
  Trimprob had similar predictive value for PCa in patients submitted to PB as mpMRI. Combined TRIMprob and mpMRI showed higher accuracy than when performed singly.
authors.affiliation: Núcleo de Urologia, Departamento de Cirurgia Pélvica, AC Camargo Cancer Center, SP, Brasil.
authors.forename: Gustavo Cardoso
authors.initials: GC
authors.lastname: Guimaraes
authors.affiliation: Núcleo de Urologia, Departamento de Cirurgia Pélvica, AC Camargo Cancer Center, SP, Brasil.
authors.forename: Walter Henriques da
authors.initials: WH
authors.lastname: Costa
authors.affiliation: Núcleo de Urologia, Departamento de Cirurgia Pélvica, AC Camargo Cancer Center, SP, Brasil.
authors.forename: Renato Almeida
authors.initials: RA
authors.lastname: Rosa
authors.affiliation: Núcleo de Urologia, Departamento de Cirurgia Pélvica, AC Camargo Cancer Center, SP, Brasil.
authors.forename: Stênio
authors.initials: S
authors.lastname: Zequi
authors.affiliation: Núcleo de Urologia, Departamento de Cirurgia Pélvica, AC Camargo Cancer Center, SP, Brasil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Favaretto
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001706:Biopsy; D003430:Cross-Sectional Studies; D003950:Diagnostic Techniques, Urological / Q000295:instrumentation*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D017430:Prostate-Specific Antigen
keywords: Diagnosis; Magnetic Resonance Imaging; Prostatic Neoplasms