title: Effects of perinatal diet and prenatal stress on the behavioural profile of aged male and female rats.
abstract: The present work studies whether chronic prenatal stress (PS) influences the long-term sex-dependent neuropsychological status of offspring and the effects of an early dietary intervention in the dam. In addition, dams were fed with either a high-fat sugar diet (HFSD) or methyl donor supplemented diet (MDSD). PS procedure did not affect body weight of the offspring. MDSD induced decreases in body weight both in male and female offspring (1 month) that were still present in aged rats. HFSD induced an increase in body weight both in male and female offspring that did not persist in aged rats. In the Porsolt forced swimming test, only young males showed increases in immobility time that were reversed by MDSD. In old female rats (20 months), PS-induced cognitive impairment in both the novel object recognition test (NORT) and in the Morris water maze that was reversed by MDSD, whereas in old males, cognitive impairments and reversion by MDSD was evident only in the Morris water maze. HFSD induced cognitive impairment in both control and PS old rats, but there was no additive effect of PS and HFSD. It is proposed here that the diversity of symptoms following PS could arise from programming effects in early brain development and that these effects could be modified by dietary intake of the dam.
authors.affiliation: 1 Department of Pharmacology and Toxicology, University of Navarra, Pamplona, Spain.
authors.forename: Xabier
authors.initials: X
authors.lastname: Bengoetxea
authors.affiliation: 2 Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Pamplona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Paternain
authors.affiliation: 1 Department of Pharmacology and Toxicology, University of Navarra, Pamplona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Martisova
authors.affiliation: 2 Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Pamplona, Spain.|3 CIBERobn, Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición, Carlos III Health Institute, Madrid, Spain.
authors.forename: Fermin I
authors.initials: FI
authors.lastname: Milagro
authors.affiliation: 2 Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Pamplona, Spain.|3 CIBERobn, Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición, Carlos III Health Institute, Madrid, Spain.|4 IDISNA, Navarra's Health Research Institute, Pamplona, Spain.
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
authors.affiliation: 2 Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Pamplona, Spain.|3 CIBERobn, Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición, Carlos III Health Institute, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Campión
authors.affiliation: 1 Department of Pharmacology and Toxicology, University of Navarra, Pamplona, Spain.|4 IDISNA, Navarra's Health Research Institute, Pamplona, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Ramírez
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D001921:Brain / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000209:etiology / Q000469:parasitology; D004032:Diet / Q000009:adverse effects; D019587:Dietary Supplements / Q000009:adverse effects; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000503:physiopathology*; D051381:Rats; D013315:Stress, Psychological / Q000150:complications*
keywords: Chronic prenatal stress; cognition; forced swimming test; high-fat sugar diet; methyl donor supplemented diet