title: Biofunctional polyethylene glycol coatings on titanium: An in vitro-based comparison of functionalization methods.
abstract: Three methods for the production of Polyethylene glycol (PEG) coatings on titanium are compared, i.e. plasma polymerization, electrodeposition and silanization. The compared deposition methods presented similar wettability (hydrophilic coatings), chemical composition assessed by XPS and thickness around 1nm. The coatings lowered albumin adsorption and presented a decreased fibroblast, Streptococcus sanguinis and Lactobacillus salivarius adhesion. Immobilization of a cell adhesion peptide (RGD) presented a higher fibroblast adhesion and no alteration of the bacterial adhesion, giving three methods for the biofunctionalization of titanium for dental implants. The feasibility of each methodology is compared in terms of the process parameters in order to provide a guide for the election of the methodology.
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Escola d'Enginyeria Barcelona Est, Technical University of Catalonia (UPC), C/Eduard Maristany 10-14, 08019 Barcelona, Spain; Centre for Research in NanoEngineering (CRNE) - UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Judit
authors.initials: J
authors.lastname: Buxadera-Palomero
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Escola d'Enginyeria Barcelona Est, Technical University of Catalonia (UPC), C/Eduard Maristany 10-14, 08019 Barcelona, Spain; Centre for Research in NanoEngineering (CRNE) - UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Calvo
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Escola d'Enginyeria Barcelona Est, Technical University of Catalonia (UPC), C/Eduard Maristany 10-14, 08019 Barcelona, Spain; Centre for Research in NanoEngineering (CRNE) - UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Torrent-Camarero
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Escola d'Enginyeria Barcelona Est, Technical University of Catalonia (UPC), C/Eduard Maristany 10-14, 08019 Barcelona, Spain.
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Gil
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Escola d'Enginyeria Barcelona Est, Technical University of Catalonia (UPC), C/Eduard Maristany 10-14, 08019 Barcelona, Spain; Centre for Research in NanoEngineering (CRNE) - UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Mas-Moruno
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Escola d'Enginyeria Barcelona Est, Technical University of Catalonia (UPC), C/Eduard Maristany 10-14, 08019 Barcelona, Spain; Centre for Research in NanoEngineering (CRNE) - UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Canal
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Escola d'Enginyeria Barcelona Est, Technical University of Catalonia (UPC), C/Eduard Maristany 10-14, 08019 Barcelona, Spain; Centre for Research in NanoEngineering (CRNE) - UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain. Electronic address: daniel.rodriguez.rius@upc.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rodríguez
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology; D018441:Biofilms / Q000254:growth & development; D002448:Cell Adhesion / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants / Q000382:microbiology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D000069996:Ligilactobacillus salivarius / Q000502:physiology; D011092:Polyethylene Glycols / Q000737:chemistry*; D013298:Streptococcus sanguis / Q000502:physiology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D011092:Polyethylene Glycols; D014025:Titanium
keywords: Biofunctionalization; Electrodeposition; Plasma polymerization; Polyethylene glycol; Silanization; Titanium implants