title: Associations of Antifungal Treatments With Prevention of Fungal Infection in Critically Ill Patients Without Neutropenia.
abstract: Are antifungal agents associated with lower rates of mortality and invasive fungal infections when administered before definitive diagnosis of an invasive fungal infection in critically ill patients without neutropenia?
  
  
  
  Antifungal treatment administered prior to diagnosis of an invasive fungal infection is not associated with either higher or lower rates of all-cause mortality. Antifungal treatment in this setting is associated with lower rates of invasive fungal infections compared with placebo or no intervention in critically ill patients without neutropenia, but the quality of the evidence is low.
authors.affiliation: Department of Biopathology and Medical Biotechnologies, Section of Anesthesia Analgesia Intensive Care and Emergency, University of Palermo, Palermo, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cortegiani
authors.affiliation: Department of Biopathology and Medical Biotechnologies, Section of Anesthesia Analgesia Intensive Care and Emergency, University of Palermo, Palermo, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Russotto
authors.affiliation: Department of Biopathology and Medical Biotechnologies, Section of Anesthesia Analgesia Intensive Care and Emergency, University of Palermo, Palermo, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Giarratano
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage; D016638:Critical Illness; D006801:Humans; D000072742:Invasive Fungal Infections; D009181:Mycoses / Q000188:drug therapy*; D009503:Neutropenia / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents