title: The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer's Disease.
abstract: OBJECTIVE
  The present study aims to analyze the levels of resistin, tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-18, and C-reactive protein (CRP) in patients with Alzheimer's disease (AD) and also investigate a potential relationship between resistin levels and TNF-α, IL-1β, IL-6, IL-18, and CRP levels in patients with AD.
  
  
  METHODS
  The study included fifty patients with AD and 30 healthy controls with normal cognitive functions. The serum resistin, TNF-α, IL-1β, IL-6, IL-18, and CRP levels were assessed. We performed a Mini-Mental State Examination (MMSE) to evaluate the general cognitive performance.
  
  
  RESULTS
  The mean serum resistin, IL-1β, IL-18, and TNF-αlevels were significantly higher in patients with AD compared with the controls (p=0.026,p=0.002,p=0.003, andp=0.038, respectively). The IL-6 and CRP levels did not differ between the groups (p=0.874 andp=0.941). The resistin levels were positively correlated with the levels of CRP and IL-18 (r=0.526,p＜0.001; r=0.402,p=0.004, respectively). MMSE scores and inflammatory markers were not correlated (p＞0.05 for all).
  
  
  CONCLUSIONS
  Serum resistin levels were significantly increased and correlated with some inflammatory markers in AD patients, suggesting that resistin might play a role in the inflammatory process of AD.
authors.affiliation: Department of Neurology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Seden
authors.initials: S
authors.lastname: Demirci
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Aynalı
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Demirci
authors.affiliation: Department of Neurology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Demirci
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Buket Cicioğlu
authors.initials: BC
authors.lastname: Arıdoğan
keywords: Alzheimer disease; Inflammation; Inflammatory cytokines; Resistin