title: Systems Biology Approach in Hypertension Research.
abstract: Systems biology is an approach to study all genes, gene transcripts, proteins, metabolites, and their interactions in specific cells, tissues, organs, or the whole organism. It is based on data derived from high-throughput analytical technologies and bioinformatics tools to analyze these data, and aims to understand the whole system rather than individual aspects of it. Systems biology can be applied to virtually all conditions and diseases and therefore also to hypertension and its underlying vascular disorders. Unlike other methods in this book there is no clear-cut protocol to explain a systems biology approach. We will instead outline some of the most important and common steps in the generation and analysis of systems biology data.
authors.affiliation: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK. Christian.Delles@glasgow.ac.uk.
authors.forename: Christian
authors.initials: C
authors.lastname: Delles
authors.affiliation: School of Natural Sciences, University of Stirling, Stirling, UK.
authors.forename: Holger
authors.initials: H
authors.lastname: Husi
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D023281:Genomics / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism*; D055432:Metabolomics / Q000379:methods; D040901:Proteomics / Q000379:methods; D049490:Systems Biology / Q000379:methods*
keywords: Bioinformatics; Data integration; Genomics; Metabolomics; Pathway analysis; Proteomics; Systems biology; Transcriptomics