title: Impact of Serum Leptin to Adiponectin Ratio on Regression of Metabolic Syndrome in High-Risk Individuals: The ARIRANG Study.
abstract: OBJECTIVE
  The ratio of serum leptin to adiponectin (L/A ratio) could be used as a marker for insulin resistance. However, few prospective studies have investigated the impact of L/A ratio on improvement of metabolic components in high-risk individuals with metabolic syndrome. We examined the association between L/A ratio and the regression of metabolic syndrome in a population-based longitudinal study.
  
  
  METHODS
  A total of 1017 subjects (431 men and 586 women) with metabolic syndrome at baseline (2005-2008) were examined and followed (2008-2011). Baseline serum levels of leptin and adiponectin were analyzed by radioimmunoassay. Area under the receiver operating characteristics curve (AUROC) analyses were used to assess the predictive ability of L/A ratio for the regression of metabolic syndrome.
  
  
  RESULTS
  During an average of 2.8 years of follow-up, metabolic syndrome disappeared in 142 men (32.9%) and 196 women (33.4%). After multivariable adjustment, the odds ratios (95% confidence interval) for regression of metabolic syndrome in comparisons of the lowest to the highest tertiles of L/A ratio were 1.84 (1.02-3.31) in men and 2.32 (1.37-3.91) in women. In AUROC analyses, L/A ratio had a greater predictive power than serum adiponectin for the regression of metabolic syndrome in both men (p=0.024) and women (p=0.019).
  
  
  CONCLUSIONS
  Low L/A ratio is a predictor for the regression of metabolic syndrome. The L/A ratio could be a useful clinical marker for management of high-risk individuals with metabolic syndrome.
authors.affiliation: Department of Humanities and Social Medicine, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Dae Ryong
authors.initials: DR
authors.lastname: Kang
authors.affiliation: Department of Preventive Medicin, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Yadav
authors.affiliation: Department of Preventive Medicin, Yonsei University Wonju College of Medicine, Wonju, Korea.|Institute of Genomic Cohort, Yonsei University, Wonju, Korea.
authors.forename: Sang Baek
authors.initials: SB
authors.lastname: Koh
authors.affiliation: Institute of Genomic Cohort, Yonsei University, Wonju, Korea.|Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Jang Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicin, Yonsei University Wonju College of Medicine, Wonju, Korea.|Institute of Genomic Cohort, Yonsei University, Wonju, Korea. dodge@yonsei.ac.kr.
authors.forename: Song Vogue
authors.initials: SV
authors.lastname: Ahn
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D011446:Prospective Studies
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin
keywords: Leptin; adiponectin; insulin resistance; metabolic syndrome; prospective study