title: Cholesterol, lipoproteins and subclinical interstitial lung disease: the MESA study.
abstract: We investigated associations of plasma lipoproteins with subclinical interstitial lung disease (ILD) by measuring high attenuation areas (HAA: lung voxels between -600 and -250 Hounsfield units) in 6700 adults and serum MMP-7 and SP-A in 1216 adults age 45-84 without clinical cardiovascular disease in Multi-Ethnic Study of Atherosclerosis. In cross-sectional analyses, each SD decrement in high density lipoprotein cholesterol (HDL-C) was associated with a 2.12% HAA increment (95% CI 1.44% to 2.79%), a 3.53% MMP-7 increment (95% CI 0.93% to 6.07%) and a 6.37% SP-A increment (95% CI 1.35% to 11.13%), independent of demographics, smoking and inflammatory biomarkers. These findings support a novel hypothesis that HDL-C might influence subclinical lung injury and extracellular matrix remodelling.
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York, USA.
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Podolanczuk
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington, USA.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Raghu
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Tsai
authors.affiliation: Department of Medicine, The Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Kawut
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Peterson
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York, USA.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sonti
authors.affiliation: Department of Statistics, Columbia University, New York, New York, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rabinowitz
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Johnson
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York, USA.|Department of Epidemiology, Columbia University Medical Center, New York, New York, USA.
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Hinckley Stukovsky
authors.affiliation: Departments of Radiology, Medicine, and Biomedical Engineering, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Hoffman
authors.affiliation: Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: J Jeffrey
authors.initials: JJ
authors.lastname: Carr
authors.affiliation: Department of Radiology, Columbia University Medical Center, New York, New York, USA.
authors.forename: Firas S
authors.initials: FS
authors.lastname: Ahmed
authors.affiliation: Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis Minnesota, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
authors.forename: Karol
authors.initials: K
authors.lastname: Watson
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York, USA.|Department of Epidemiology, Columbia University Medical Center, New York, New York, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Shea
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York, USA.|Department of Epidemiology, Columbia University Medical Center, New York, New York, USA.
authors.forename: David J
authors.identifier: 0000-0001-5258-0228
authors.initials: DJ
authors.lastname: Lederer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000000981:diagnostic imaging; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000097:blood; D008875:Middle Aged; D011446:Prospective Studies; D037662:Pulmonary Surfactant-Associated Protein A / Q000097:blood*; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008074:Lipoproteins; D037662:Pulmonary Surfactant-Associated Protein A; D020783:Matrix Metalloproteinase 7
keywords: Clinical Epidemiology; Idiopathic pulmonary fibrosis; Imaging/CT MRI etc; Interstitial Fibrosis