title: Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese.
abstract: Phytosterols found naturally in plants are known to reduce cholesterol absorption in the gut. The traditional southern Chinese diet typically contains many vegetables and not much meat, and there is high prevalence of lactose intolerance in Chinese; we therefore aimed to test if phytosterols-enriched milk is effective in lowering serum LDL-cholesterol in Chinese. Two hundred and twenty-one participants (41 men and 180 women; age 24-79) without cholesterol-lowering drugs or diabetes mellitus were randomized to daily intake of phytosterols-enriched low-fat milk which contained 1.5 g phytosterols per day (N = 110) or a conventional low-fat milk (N = 111) for three weeks. Fasting bloods were taken before and at the end of the study for the measurement of lipid and glucose profile. Physical examination was also performed. Comparing treatment with control, treatment group had significant decrease in serum LDL-cholesterol level (9.5 ± 2.0%; p < 0.0001). Phytosterols intake also decreased total cholesterol (P < 0.0001) and diastolic blood pressure (P = 0.01). Consumption of a phytosterols-enriched low-fat milk led to a significant fall in LDL-cholesterol, total cholesterol, and diastolic blood pressure in Chinese. This can be recommended as part of a healthy diet for people. (ClinicalTrials.gov identifier: NCT02541201; Date of registration: 26 Aug 2015).
authors.affiliation: Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong.|Department of Medicine, University of Hong Kong, Pokfulam, Hong Kong.|State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Ching-Lung
authors.initials: CL
authors.lastname: Cheung
authors.affiliation: Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong.|Department of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Daniel Ka-Chun
authors.initials: DK
authors.lastname: Ho
authors.affiliation: Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Chor-Wing
authors.initials: CW
authors.lastname: Sing
authors.affiliation: Department of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Man-Fung
authors.initials: MF
authors.lastname: Tsoi
authors.affiliation: Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Vincent Ka-Fai
authors.initials: VK
authors.lastname: Cheng
authors.affiliation: Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Grace Koon-Yee
authors.initials: GK
authors.lastname: Lee
authors.affiliation: Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Yuk-Nam
authors.initials: YN
authors.lastname: Ho
authors.affiliation: Department of Medicine, University of Hong Kong, Pokfulam, Hong Kong.|State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Bernard M Y
authors.initials: BM
authors.lastname: Cheung
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000924:Anticholesteremic Agents; D044466:Asian People; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D005260:Female; D005527:Food, Fortified / Q000032:analysis*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008892:Milk / Q000737:chemistry*; D010840:Phytosterols / Q000494:pharmacology* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000924:Anticholesteremic Agents; D010840:Phytosterols; D002784:Cholesterol