title: Applications of Metabolomics in Cancer Studies.
abstract: Since the start of metabolomics as a field of research, the number of studies related to cancer has grown to such an extent that cancer metabolomics now represents its own discipline. In this chapter, the applications of metabolomics in cancer studies are explored. Different approaches and analytical platforms can be employed for the analysis of samples depending on the goal of the study and the aspects of the cancer metabolome being investigated. Analyses have concerned a range of cancers including lung, colorectal, bladder, breast, gastric, oesophageal and thyroid, amongst others. Developments in these strategies and methodologies that have been applied are discussed, in addition to exemplifying the use of cancer metabolomics in the discovery of biomarkers and in the assessment of therapy (both pharmaceutical and nutraceutical). Finally, the application of cancer metabolomics in personalised medicine is presented.
authors.affiliation: Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad CEU San Pablo, Campus Monteprincipe, Madrid, Spain. emily.armitage@glasgow.ac.uk.|Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow, UK. emily.armitage@glasgow.ac.uk.|Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. emily.armitage@glasgow.ac.uk.
authors.forename: Emily Grace
authors.initials: EG
authors.lastname: Armitage
authors.affiliation: Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Ciborowski
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism*; D057285:Precision Medicine
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarker; Cancer; Chemotherapy; Effect of treatment; Metabolomics; Nutraceutical; Personalised medicine; Pharmaceutical