title: [The key role of AMP-activated protein kinase (AMPK) in aging process].
abstract: Aging is one of the most extensively studied biological process and yet still some of its aspects remain elusive. It appears that AMP - activated protein kinase (AMPK) plays an important role in many processes of aging, but this fact is often neglected in the studies on aging. This work summarizes the information about AMPK participation in the aging process. AMPK participation in the regulation of aging was indicated in the mechanisms dependent on: caloric restriction, mTOR, p53, sirtuins, autophagy, inflammation and the effects caused by polyphenols.
authors.affiliation: Department of Metabolic Regulation, Biochemistry Institute, Faculty of Biology, University of Warsaw, 1 Miecznikowa St., 02-096 Warszawa, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Michalik
authors.affiliation: Department of Metabolic Regulation, Biochemistry Institute, Faculty of Biology, University of Warsaw, 1 Miecznikowa St., 02-096 Warszawa, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Jarzyna
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000502:physiology*; D000375:Aging / Q000378:metabolism*; D031204:Caloric Restriction; D006801:Humans; D008136:Longevity; D037761:Sirtuins; D058570:TOR Serine-Threonine Kinases
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D037761:Sirtuins
keywords: AMPK; aging; longevity