title: Nanoparticle-Programmed Surface for Drug Release and Cell Regulation via Reversible Hybridization Reaction.
abstract: A surface directly connects the bulk of a material to its surroundings. The ability to dynamically regulate the surface without affecting the bulk of a material holds great potential for new applications. The purpose of this work was to demonstrate that the surface can be dynamically changed using nanoparticles and oligonucleotides (ODNs) in a reversible and reiterative manner. A dual-functional nanogel was synthesized as the model of nanoparticles using miniemulsion polymerization and click chemistry. The nanogel can not only adsorb drugs for sustained drug release but also bind a surface functionalized with complementary ODNs. Importantly, hybridization reaction and ODN degradation can drive reversible and reiterative nanogel binding to the surface for dynamic change, which in principle is unlimited. Moreover, nanogel-mediated dynamic change offers the surface with the drug-releasing function for inhibiting the growth of surrounding cells. Because nanogels can be replaced by any functional nanoparticles with a diverse array of properties, nanoparticle-programmed surface change constitutes a promising platform for various applications such as drug delivery and stent implantation.
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.|Department of Chemistry, College of Chemistry and Chemical Engineering & College of Materials, Xiamen University , Xiamen 361005, China.
authors.forename: Pinliang
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Shihui
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Jinping
authors.initials: J
authors.lastname: Lai
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.|Department of Chemistry, College of Chemistry and Chemical Engineering & College of Materials, Xiamen University , Xiamen 361005, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering & College of Materials, Xiamen University , Xiamen 361005, China.
authors.forename: Changjian
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Shi
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Yong
authors.identifier: http://orcid.org/0000-0002-2244-1742
authors.initials: Y
authors.lastname: Wang
mesh_terms: D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D053758:Nanoparticles; D011092:Polyethylene Glycols; D011094:Polyethyleneimine
chemical_list: D004337:Drug Carriers; D011092:Polyethylene Glycols; D011094:Polyethyleneimine
keywords: DNAs; cell regulation; hydrogels; nanoparticles; surfaces