title: Transplantation tolerance: the big picture. Where do we stand, where should we go?
abstract: A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three-stage tolerance-inducing strategy for transplanted tissues.
authors.affiliation: Sir William Dunn School of Pathology, South Parks Road, Oxford, UK.
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion; D007165:Immunosuppression Therapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology; D016377:Organ Transplantation; D014181:Transplantation Immunology; D023001:Transplantation Tolerance
keywords: anergy; suppression; tolerance; transplantation; tumour immunology