title: Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study.
abstract: OBJECTIVE
  This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients.
  
  
  METHODS
  A 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24). General HRQoL was assessed by using the Medical Outcomes' 36-Item Short Form Health Survey (SF-36) and the EuroQoL 5-dimension questionnaire (EQ-5D). All the assessments were performed before and after the 24-week treatment period.
  
  
  RESULTS
  A total of 20 CD patients were enrolled in this study from April to December 2011. CDIP-58 and CDQ-24 scores, which assess disease-specific HRQoL, showed a significant improvement after 24 weeks of treatment by botulinum toxin A (P<0.001). However, EQ-5D and SF-36 scores, which assess general HRQoL, showed no significant improvement after the treatment (P>0.05).
  
  
  CONCLUSIONS
  CD patients' disease-specific HRQoL improved after being treated with multiple botulinum toxin A injections. However, general HRQoL was not improved.
authors.affiliation: Division of Neurology, Department of Medicine, Rajvithi Hospital, Department of Medical Services, Public Health Ministry, Bangkok, Thailand; Department of Medicine, College of Medicine, Rangsit University, Bangkok, Thailand.
authors.forename: Subsai
authors.initials: S
authors.lastname: Kongsaengdao
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Thailand.
authors.forename: Benchalak
authors.initials: B
authors.lastname: Maneeton
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Thailand.
authors.forename: Narong
authors.initials: N
authors.lastname: Maneeton
keywords: 36-Item Short Form Health Survey; Cervical Dystonia Impact Profile-58 questionnaire; Craniocervical Dystonia Questionnaire-24; EuroQoL 5-dimension questionnaire; botulinum toxin A; cervical dystonia; the health-related quality of life