title: Aptamers in Bordeaux, 24-25 June 2016.
abstract: The symposium covered the many different aspects of the selection and the characterization of aptamers as well as their application in analytical, diagnostic and therapeutic areas. Natural and artificial riboswitches were discussed. Recent advances for the design of mutated polymerases and of chemically modified nucleic acid bases that provide aptamers with new properties were presented. The power of aptamer platforms for multiplex analysis of biomarkers of major human diseases was described. The potential of aptamers for the treatment of cancer or cardiovascular diseases was also presented. Brief summaries of the lectures presented during the symposium are given in this report. A second edition of "Aptamers in Bordeaux" will take place on September 2017 (http://www.aptamers-in-bordeaux.com/).
authors.affiliation: ARNA Laboratory, Inserm U1212, CNRS UMR5320, University of Bordeaux, Bordeaux 33076, France. jean-jacques.toulme@inserm.fr.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Toulmé
authors.affiliation: Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA. paloma-giangrande@uiowa.edu.
authors.forename: Paloma H
authors.initials: PH
authors.lastname: Giangrande
authors.affiliation: Unit Chemical Biology and Medicinal Chemistry, University of Bonn, Bonn 53121, Germany. gmayer@uni-bonn.de.
authors.forename: Günter
authors.initials: G
authors.lastname: Mayer
authors.affiliation: Department of Biology, Technical University Darmstadt, Darmstadt 64287, Germany. bsuess@bio.tu-darmstadt.de.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Suess
authors.affiliation: CEA, DRF, I2BM, MIRCen, CNRS UMR 9199, University Paris Saclay, Fontenay aux Roses 92265, France. frederic.duconge@cea.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Ducongé
authors.affiliation: Department of Surgery, Duke University, Durham, NC 27710, USA. bruce.sullenger@duke.edu.
authors.forename: Bruce
authors.initials: B
authors.lastname: Sullenger
authors.affiliation: Institute of Experimental Endocrinology and Oncology, CNR, Naples 80145, Italy. defranci@unina.it.
authors.forename: Vittorio
authors.initials: V
authors.lastname: de Franciscis
authors.affiliation: ARNA Laboratory, Inserm U1212, CNRS UMR5320, University of Bordeaux, Bordeaux 33076, France. fabien.darfeuille@inserm.fr.
authors.forename: Fabien
authors.initials: F
authors.lastname: Darfeuille
authors.affiliation: Department of Molecular Pharmacochemistry, CNRS UMR5063, University Grenoble Alpes, Saint Martin d'Hères 38400, France. eric.peyrin@univ-grenoble-alpes.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Peyrin
keywords: SELEX; aptamer; biosensor; cancer; cardiovascular; cell-targeted aptamers; imaging; in vitro selection; oligonucleotide; riboswitch; synthetic biology