title: Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children.
abstract: This multicenter clinical trial was conducted to examine current practice of benign epilepsy with centrotemporal spikes and especially address the question that in what circumstances 1 antiepileptic drug (AED) should be preferred.Twenty-five medical centers participate in this clinical trial. The general information, clinical information, and treatment status were collected under the guidance of clinicians and then analyzed. Difference between different treatment groups was compared, and usefulness of the most commonly used AEDs was evaluated.A total of 1817 subjects were collected. The average age of the subject was 8.81 years. The average age of onset is 6.85 years (1-14 years). Male-to-female ratio is 1.13:1. A total of 62.9% of the patients are receiving monotherapies, and 10.6% are receiving multidrug therapy. Both age and course of disease of treated rolandic epilepsy (RE) patients are significantly different from those of untreated patients. Bilateral findings on electroencephalography (EEG) are less seen in patients with monotherapy compared with patients with multidrug therapy. Except for 25.4% patients not taking any AEDs, oxcarbazepine (OXC), sodium valproate (VPA), and levetiracetam (LEV) are the most commonly used 3 AEDs. VPA and LEV are commonly used in add-on therapy. OXC and LEV are more effective as monotherapy than VPA.Age of onset of Chinese RE patients is 6.85 years. Bilateral findings on EEG could be a risk factor to require multidrug therapy. In Chinese patients, OXC, VPA, and LEV are most commonly used AEDs as monotherapy and OXC and LEV are more effective than VPA.
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Department of Neurology, Wuhan Children's Hospital Wuhan Shi, Hubei Sheng Department of Neurology, Tianjin Children's Hospital, Tianjin Department of Pediatrics, Henan Province People's Hospital, Henan Department of Neurology, Harbin Children's Hospital, Heilongjiang Sheng Department of Neurology, Shenzhen Children's Hospital, Shenzhen Shi, Guangdong Sheng Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang Shi, Liaoning Sheng Department of Neurology, Guangzhou Women's and Children's Medical Center, Guangzhou Department of Neurology, Tangshan Women's Children's Hospital, Tangshan Shi, Hebei Sheng Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Department of Pediatrics, Linyi People's Hospital, Linyi, China.
authors.forename: Meng-Jia
authors.initials: MJ
authors.lastname: Liu
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Su
authors.forename: Xiu-Yu Shi
authors.initials: XS
authors.lastname: Md
authors.forename: Ge-Fei
authors.initials: GF
authors.lastname: Wu
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jian-Xiang
authors.initials: JX
authors.lastname: Liao
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Jian-Ning
authors.initials: JN
authors.lastname: Mai
authors.forename: Jing-Yun
authors.initials: JY
authors.lastname: Gao
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Shu
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Huang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zou
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000927:Anticonvulsants / Q000008:administration & dosage*; D001921:Brain / Q000503:physiopathology; D002220:Carbamazepine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002648:Child; D002675:Child, Preschool; D002681:China; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D000078330:Oxcarbazepine; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014635:Valproic Acid / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000077287:Levetiracetam; D014635:Valproic Acid; D000078330:Oxcarbazepine; D010889:Piracetam