title: Neutrophil Gelatinase-Associated Lipocalin Levels During Pneumoperitoneum.
abstract: OBJECTIVE
  A temporary deterioration in renal function during pneumoperitoneum has been reported, but the extent is not known. A new marker for the early detection of renal injury, neutrophil gelatinase-associated lipocalin (NGAL), has been shown to increase in various conditions that affect renal function. This study was conducted to explore detrimental effects of pneumoperitoneum in laparoscopic surgery on renal function by studying levels of urinary NGAL (uNGAL).
  
  
  METHODS
  Thirty-two women scheduled to undergo laparoscopic surgery in a gynecology clinic were recruited. NGAL was measured in urine collected at the beginning (0 h) and at 2 and 24 hours after the initiation of surgery. Hemodynamic parameters were analyzed immediately after intubation and before desufflation.
  
  
  RESULTS
  Levels of uNGAL increased from 5.45 ng/mL at 0 hours to 6.35 ng/mL at 2 hours and to 6.05 ng/mL at 24 h; however, there was no significant change in uNGAL levels at the collection time points. Intraoperative oliguria was observed in all cases, and the severity increased with the duration of surgery. uNGAL levels did not correlate with the duration of surgery or pneumoperitoneum.
  
  
  CONCLUSIONS
  In patients with normal renal functions, pneumoperitoneum results in transient oliguria without any early renal damage, as indicated by nonsignificant changes in uNGAL levels.
authors.affiliation: Department of Obstetrics and Gynecology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Kiseli
authors.affiliation: Department of Obstetrics and Gynecology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Gamze Sinem
authors.initials: GS
authors.lastname: Caglar
authors.affiliation: Department of Anesthesiology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Yilmaz
authors.affiliation: Department of Obstetrics and Gynecology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Asli Yarci
authors.initials: AY
authors.lastname: Gursoy
authors.affiliation: Department of Biochemistry, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Candar
authors.affiliation: Department of Obstetrics and Gynecology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Emre Goksan
authors.initials: EG
authors.lastname: Pabuccu
authors.affiliation: Department of Anesthesiology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Zuleyha Kazak
authors.initials: ZK
authors.lastname: Bengisun
authors.affiliation: Department of Anesthesiology, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Tuzuner
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000652:urine; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007431:Intraoperative Complications; D010535:Laparoscopy; D000071068:Lipocalin-2 / Q000652:urine*; D008875:Middle Aged; D009846:Oliguria / Q000209:etiology; D011028:Pneumoperitoneum, Artificial; D055815:Young Adult
chemical_list: D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2
keywords: Laparoscopy; Neutrophil Gelatinase-Associated Lipocalin; pneumoperitoneum; renal function