title: Efficacy of FurosapTM, a novelTrigonella foenum-graecumseed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers.
abstract: Background: Dietary fiber rich fenugreek (Trigonella foenum-graecum) seeds have exhibited cardioprotective, hypolipidemic and other health benefits. Furosap (FS), an innovative, patented, 20% protodioscin-enriched extract was developed in our laboratory from fenugreek seeds. This study examined the free and total testosterone levels, sperm profile and morphology, sexual health, mood and mental alertness, and broad spectrum safety parameters of FS in 50 male volunteers following supplementation over a period of 12 weeks.Methods:Institutional Review Board (IRB) and other regulatory approvals were obtained for our study. This one-arm, open-labelled, multi-center study was conducted in 50 male volunteers (age: 35 to 65 years) over a period of 12 weeks to determine the efficacy of FS (500 mg/day/subject) on free and total testosterone levels, sperm profile, sperm morphology, libido and sexual health, mood and mental alertness, and broad spectrum safety parameters.Results:Free testosterone levels were improved up to 46% in 90% of the study population. 85.4% of the study population showed improvements in sperm counts. Sperm morphology improved in 14.6% of volunteers. Majority of the subjects enrolled in the study demonstrated improvements in mental alertness and mood. Furthermore, cardiovascular health and libido were significantly improved. Extensive safety parameters were evaluated which included blood chemistry data. No significant changes were observed in serum lipid function, cholesterol, triglyceride, HDL and LDL levels, hemogram (CBC), hepatotoxicity and nephrotoxicity.Conclusion:Overall, the results demonstrate that FS, enriched in 20% protodioscin, is safe and effective in attenuating testosterone levels, healthy sperm profile, mental alertness, cardiovascular health and overall performance in human subjects.
authors.affiliation: Department of Medicine, BBD University, Lucknow, India; Metabolic Physician, SHK Diabetes Clinic & Research Center, Lucknow, India.
authors.forename: Anuj
authors.initials: A
authors.lastname: Maheshwari
authors.affiliation: Department of Physiology, King George's Medical University, Lucknow, India.
authors.forename: Narsingh
authors.initials: N
authors.lastname: Verma
authors.affiliation: Cepham Research Center, Piscataway, NJ, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Swaroop
authors.affiliation: Cepham Research Center, Piscataway, NJ, USA.
authors.forename: Manashi
authors.initials: M
authors.lastname: Bagchi
authors.affiliation: Georgetown University Medical Center, Washington, DC, USA.
authors.forename: Harry G
authors.initials: HG
authors.lastname: Preuss
authors.affiliation: Chemical Resources, Panchkula, Haryana, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Tiwari
authors.affiliation: Cepham Research Center, Piscataway, NJ, USA; University of Houston College of Pharmacy, Houston, TX, USA.
authors.forename: Debasis
authors.initials: D
authors.lastname: Bagchi
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D000368:Aged; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D064368:Healthy Volunteers; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013739:Testosterone / Q000097:blood*
chemical_list: C000619212:Furosap; D010936:Plant Extracts; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate
keywords: Cardiovascular health; Fenugreeks seed extract (FurosapTM); Mental alertness; Mood; Protodioscin; Safety; Sperm profile; Testosterone