title: Recent progress in drug delivery of pluronic P123: pharmaceutical perspectives.
abstract: This review focuses on recent investigations that used Pluronic P123 (P123) as pharmaceutical ingredients in vesicle, micelle, mixed micelle, in situ gel, tablet and emulsion. The main results from these studies show that P123 can significantly increase the stability of incorporated hydrophobic drugs with enhanced in vitro cytotoxicity and cellular uptake of anticancer drugs. Moreover, modified forms of P123 with RGD, folate or other targeted marker have shown its therapeutic potentials in various types of tumors and cancers. Furthermore, modified forms of P123 alone and/or mixed with other copolymers have less toxic effects and more tumor-specific delivery of anticancer drugs. They are promising materials as a nanoplatform for the drug delivery. Finally, the future perspectives of the field are briefly discussed.
authors.affiliation: a Department of Pharmacy , Hebei North University , Zhangjiakou , PR China.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Zhao
authors.affiliation: a Department of Pharmacy , Hebei North University , Zhangjiakou , PR China.
authors.forename: Wan-Ming
authors.initials: WM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009842:Oligopeptides / Q000008:administration & dosage; D011060:Poloxalene / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D009842:Oligopeptides; C464484:pluronic block copolymer P123; C047981:arginyl-glycyl-aspartic acid; D011060:Poloxalene
keywords: Pluronic P123; anticancer drugs; drug delivery; modified Pluronic P123; receptor-mediated drug delivery