title: Gold nanotriangles: scale up and X-ray radiosensitization effects in mice.
abstract: In the past decade, there has been considerable interest in radiosensitization using gold nanoparticles that accumulate specifically in cancerous tissue while sparing normal tissues. Despite this interest, it remains unclear which nanoparticle morphologies, cellular uptake, or cytoplasmic distribution elicit optimal radiosensitization. We introduce gold nanotriangles (AuNTs) as a possible X-ray radiotherapy sensitizer. In this study, we first explored a large-scale synthetic method for the production of high quality monodisperse AuNTs. Second, we conducted in vitro and in vivo experiments to evaluate the effect of PEGylated AuNTs (pAuNTs) on cellular uptake, cytotoxicity, bio-distribution, and radiosensitization on radiation-resistant human Glioblastoma Multiforme (GBM) cells. Our results suggest that the new scale up synthesis methodology consistently produced high quality AuNTs and pAuNTs which had nonspecific cellular uptake without any obvious cytotoxicity and exhibited excellent radiosensitization.
authors.affiliation: Department of Experimental Radiation Oncology, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Bhattarai
authors.forename: P J
authors.initials: PJ
authors.lastname: Derry
authors.forename: K
authors.initials: K
authors.lastname: Aziz
authors.forename: P K
authors.initials: PK
authors.lastname: Singh
authors.forename: A M
authors.initials: AM
authors.lastname: Khoo
authors.forename: A S
authors.initials: AS
authors.lastname: Chadha
authors.forename: A
authors.initials: A
authors.lastname: Liopo
authors.forename: E R
authors.initials: ER
authors.lastname: Zubarev
authors.forename: S
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D005909:Glioblastoma / Q000532:radiotherapy*; D006046:Gold; D006801:Humans; D061986:MCF-7 Cells; D008297:Male; D053768:Metal Nanoparticles; D051379:Mice; D011838:Radiation-Sensitizing Agents; D014965:X-Rays; D023041:Xenograft Model Antitumor Assays
chemical_list: D011838:Radiation-Sensitizing Agents; D006046:Gold