title: ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus.
abstract: Association between ACE gene I/D polymorphism and the risk of overweight/obesity remains controversial. We investigated the possible relationship between ACE gene I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients. In this study, obesity was defined as a body mass index (BMI) value ≥ 25 kg/m2and subjects were classified into 4 groups (lean, normal, overweight, and obese). PCR (polymerase chain reaction) was used to detect the ACE gene I/D polymorphism in T2DM patients. Metabolic measurements including blood glucose, lipid profile, and blood pressure were obtained. Frequencies of the ACE genotypes (DD, ID, and II) were not significant among the 4 groups of BMI-defined patients (P= 0.679) while ACE II carriers showed higher systolic blood pressure (SBP) and pulse pressure (PP) (allP< 0.050). Hyperglycemia, hypertension, and dyslipidemia in these T2DM patients were found to be significantly associated with BMI. In conclusion, the relationship of ACE gene I/D polymorphism with obesity is insignificant in Chinese patients with T2DM. SBP and PP might be higher in the ACE II carriers than in the DD and ID carriers.
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China.
authors.forename: Yan-Hong
authors.identifier: 0000-0002-7825-2334
authors.initials: YH
authors.lastname: Pan
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Huang
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China.
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China.
authors.forename: Yin-Ling
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Geng
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China.
authors.forename: Xiao-Xi
authors.identifier: 0000-0001-8406-4113
authors.initials: XX
authors.lastname: Zhang
authors.affiliation: Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China.
authors.forename: Hai-Lu
authors.identifier: 0000-0001-6670-3604
authors.initials: HL
authors.lastname: Zhao
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics*; D050177:Overweight / Q000150:complications / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D013851:Thinness / Q000150:complications / Q000235:genetics*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A