title: Saccharomyces boulardii administration can inhibit the formation of gastric lymphoid follicles induced by Helicobacter suis infection.
abstract: Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue lymphoma compared with other Helicobacter species in humans and animals. Saccharomyces boulardii has been established as an adjunct to H. pylori eradication treatment, but the effect of S. boulardii administration alone on Helicobacter infection remains unclear. Here, we found that S. boulardii administration effectively decreased the bacterial load of H. suis and inhibited the formation of lymphoid follicles in the stomach post-infection. The levels of H. suis-specific immunoglobulin A (IgA) and secretory IgA in the gastric juice and small intestinal secretions and the production of mouse β-defensin-3 in the small intestinal secretions were significantly increased by S. boulardii administration at 12 weeks after H. suis infection. In addition, feeding with S. boulardii inhibited the expression of inflammatory cytokines and lymphoid follicle formation-related factors after H. suis infection. These results suggested that S. boulardii may be useful for the prevention and treatment of Helicobacter infection-related diseases in humans.
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Zi-Bin
authors.initials: ZB
authors.lastname: Tian
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yu
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Mao
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Jing
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Xue-Li
authors.initials: XL
authors.lastname: Ding
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
authors.forename: Ruo-Ming
authors.initials: RM
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Qilu Hospital of Shandong University (Qingdao), Qingdao 266000, China.
authors.forename: Shuai-Qing
authors.initials: SQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000276:immunology; D016481:Helicobacter Infections / Q000382:microbiology*; D018247:Helicobacter heilmannii / Q000502:physiology*; D007070:Immunoglobulin A / Q000276:immunology; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D051379:Mice; D056265:Microbial Interactions / Q000276:immunology*; D019936:Probiotics / Q000008:administration & dosage*; D000069983:Saccharomyces boulardii / Q000502:physiology*; D013270:Stomach / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology; D013997:Time Factors; D023083:beta-Defensins / Q000096:biosynthesis
chemical_list: D016207:Cytokines; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D018836:Inflammation Mediators; D023083:beta-Defensins; C540070:beta-defensin 3, mouse
keywords: Gastric lymphoid follicles; Helicobacter suis; Saccharomyces boulardii; secretory immunoglobulin A