title: Cryo-EM Captures the Dynamics of Ion Channel Opening.
abstract: In this issue of Cell, Hite and MacKinnon (2017) report the open conformation structure of Slo2.2, a neuronal Na+-activated K+channel. More importantly, 3D classification of electron cryomicroscopy (cryo-EM) images allows visualization of the structural transition that occurs as the open probability of individual channels increases with added sodium.
authors.affiliation: Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Canada M5G 0A4; Department of Biochemistry, The University of Toronto, Canada M5S 1A8; Department of Medical Biophysics, The University of Toronto, Canada M5G 1L7. Electronic address: john.rubinstein@utoronto.ca.
authors.forename: John L
authors.initials: JL
authors.lastname: Rubinstein
mesh_terms: D020285:Cryoelectron Microscopy; D007473:Ion Channels; D012964:Sodium
chemical_list: D007473:Ion Channels; D012964:Sodium