title: Characterization, antifungal and cytotoxic evaluation of green synthesized zinc oxide nanoparticles using Ziziphus nummularia leaf extract.
abstract: Zinc oxide nanoparticles (ZnO NPs) were synthesized using Ziziphus nummularia leaf extract. The characterization was done by various spectral analysis and antifungal (anti-candidal) activity against multidrug resistant clinical isolates and their cytotoxic potential was evaluated. The ZnO NPs were 17.33 nm in size and were spherical/irregular in shape. The antifungal activity of ZnO NPs was better than four standard azole antibiotics and they also showed potent cytotoxic effect against HeLa cancer cell line. The results strongly suggest the applicability of green synthesized ZnO NPs as antifungal agent and also its use in cancer diagnosis and treatment.
authors.affiliation: a Department of Biosciences (UGC-CAS) , Saurashtra University , Rajkot , Gujarat , India.
authors.forename: Hemali
authors.initials: H
authors.lastname: Padalia
authors.affiliation: a Department of Biosciences (UGC-CAS) , Saurashtra University , Rajkot , Gujarat , India.
authors.forename: Sumitra
authors.initials: S
authors.lastname: Chanda
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D055772:Green Chemistry Technology; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D015034:Zinc Oxide / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D015034:Zinc Oxide
keywords: Zinc oxide nanoparticles; Ziziphus nummularia; antifungal activity; cytotoxic activity; green synthesis