title: Completeness of pathology reports in stage II colorectal cancer.
abstract: BACKGROUND
  The completeness of the pathological examination of resected colon cancer specimens is important for further clinical management. We reviewed the pathological reports of 356 patients regarding the five factors (pT-stage, tumor differentiation grade, lymphovascular invasion, tumor perforation and lymph node metastasis status) that are used to identify high-risk stage II colon cancers, as well as their impact on overall survival (OS).
  
  
  METHODS
  All patients with stage II colon cancer who were included in the first five years of the MATCH study (1 July 2007 to 1 July 2012) were selected (n = 356). The hazard ratios of relevant risk factors were calculated using Cox Proportional Hazards analyses.
  
  
  RESULTS
  In as many as 69.1% of the pathology reports, the desired information on one or more risk factors was considered incomplete. In multivariable analysis, age (HR: 1.07, 95%CI 1.04-1.10, p < .001), moderately- (HR: 0.35, 95%CI 0.18-0.70, p = .003) and well (HR 0.11, 95%CI 0.01-0.89, p = .038) differentiated tumors were significantly associated with OS.
  
  
  CONCLUSIONS
  Pathology reports should better describe the five high-risk factors, in order to enable proper patient selection for further treatment. Chemotherapy may be offered to stage II patients only in select instances, yet a definitive indication is still unavailable.
authors.affiliation: a Department of Surgery , Erasmus MC University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Stefan
authors.initials: S
authors.lastname: Büttner
authors.affiliation: a Department of Surgery , Erasmus MC University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Zarina S
authors.initials: ZS
authors.lastname: Lalmahomed
authors.affiliation: a Department of Surgery , Erasmus MC University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Robert R J
authors.initials: RR
authors.lastname: Coebergh van den Braak
authors.affiliation: b Department of Gastroenterology & Hepatology , Erasmus MC University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Bettina E
authors.initials: BE
authors.lastname: Hansen
authors.affiliation: d Department of Surgery , Maasstad Hospital , Rotterdam , The Netherlands.
authors.forename: Peter Paul L O
authors.initials: PP
authors.lastname: Coene
authors.affiliation: e Department of Surgery , Reinier de Graaf Hospital , Delft , The Netherlands.
authors.forename: Jan Willem T
authors.initials: JW
authors.lastname: Dekker
authors.affiliation: f Department of Surgery , Elisabeth-Tweesteden Hospital , Tilburg , The Netherlands.
authors.forename: David D E
authors.initials: DD
authors.lastname: Zimmerman
authors.affiliation: g Department of Surgery , IJsselland Hospital , Capelle a/d IJssel , The Netherlands.
authors.forename: Geert W M
authors.initials: GW
authors.lastname: Tetteroo
authors.affiliation: h Department of Surgery , Ikazia Hospital , Rotterdam , The Netherlands.
authors.forename: Wouter J
authors.initials: WJ
authors.lastname: Vles
authors.affiliation: i Department of Surgery , Sint Franciscus Hospital , Rotterdam , The Netherlands.
authors.forename: Wietske W
authors.initials: WW
authors.lastname: Vrijland
authors.affiliation: j Department of Pathology , Elisabeth-Tweesteden Hospital , Tilburg , The Netherlands.
authors.forename: Ruth E M
authors.initials: RE
authors.lastname: Fleischeuer
authors.affiliation: j Department of Pathology , Elisabeth-Tweesteden Hospital , Tilburg , The Netherlands.
authors.forename: Anneke A M
authors.initials: AA
authors.lastname: van der Wurff
authors.affiliation: k Department of Pathology , Maasstad Hospital , Rotterdam , The Netherlands.
authors.forename: Mike
authors.initials: M
authors.lastname: Kliffen
authors.affiliation: l Pathan Rotterdam , Reinier de Graaf Hospital , Delft , The Netherlands.
authors.forename: Rolf
authors.initials: R
authors.lastname: Torenbeek
authors.affiliation: m Department of Pathology , Reinier de Graaf Hospital , Delft , The Netherlands.
authors.forename: J H Carel
authors.initials: JH
authors.lastname: Meijers
authors.affiliation: c Department of Pathology , Erasmus MC University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Michael
authors.initials: M
authors.lastname: Doukas
authors.affiliation: a Department of Surgery , Erasmus MC University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Jan N M
authors.initials: JN
authors.lastname: IJzermans
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003082:Colectomy; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D003113:Colonoscopy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D012307:Risk Factors; D015996:Survival Rate
keywords: Colorectal cancer; pathology reporting; prognostic factors