title: The Association Between C424c/A Polymorphism Within the IL-25 Gene and Multiple Sclerosis.
abstract: BACKGROUND
  Multiple Sclerosis (MS) is a common autoimmune system disease which affects the central nervous system. It has been documented that interleukin-25 (IL-25) plays key roles in suppressing Th1 responses, which is increased during MS.
  
  
  OBJECTIVE
  The aim of this study was to investigate the c424C/A polymorphism within the IL-25 gene in MS patients in comparison to healthy controls.
  
  
  METHODS
  In this case-control study, 74 patients with MS and 75 healthy controls were selected. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used in order to determine c424C/A polymorphism within the IL-25 gene.
  
  
  RESULTS
  The results showed that there was no statistical significant difference in distribution of genotype (AA, AC and CC) and allele (A and C) frequencies between MS patients and healthy controls (P = 0.901 and P = 0.728, respectively).
  
  
  CONCLUSIONS
  In conclusion, it appears that the c424C/A polymorphism within the IL-25 gene has no significant relationship with MS, and this polymorphism is probably not associated with MS complications, its onset and gender distribution.
authors.affiliation: Physiology Pharmacology Research Center, Rafsanjan University of Medical Sciences, Kerman, IR Iran.
authors.forename: Lida
authors.initials: L
authors.lastname: Zare
authors.affiliation: Department of Social Medicine, Medical School Research Center, Rafsanjan University of Medical Sciences, Kerman, IR Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Sheikh Fathollahi
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Kerman, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kazemi Arababadi
authors.affiliation: Department of Neurosurgery, Alborz Hospital, Karaj, IR Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Shamsizadeh
authors.affiliation: Department of Neurosurgery, Alborz Hospital, Karaj, IR Iran.
authors.forename: Behnam
authors.initials: B
authors.lastname: Daneshpajouh
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Kerman, IR Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Zainodini
authors.affiliation: Physiology Pharmacology Research Center, Rafsanjan University of Medical Sciences, Kerman, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Allahtavakoli
keywords: CCL25; Genetic; Multiple Sclerosis; Polymorphism