title: [A Case of an Elderly Patient with Unresectable Gastric Cancer Treated by Paclitaxel and Ramucirumab].
abstract: An 80-year-old man was admitted to our hospital with appetite loss in December 2014. Gastroduodenal scope, abdominal computed tomography(CT), and laparoscopy revealed type 4 advanced gastric cancer(poorly differentiated adenocarcinoma) with multiple lymph node(LN)involvement and multiple peritoneal metastasis. S-1(80mg/body)was administrated between January 2015 and September 2015 in the outpatient clinic. A partial response was obtained, but a gastric tumor, ascites, and LN re-growth were observed. Since October 2015, paclitaxel(PTX)(70mg/m2; day 1, 8, and 15)and ramucir- umab(RAM)(8mg/kg; day 1 and 15)have been administered. After 2 courses, bi-weekly PTX plus RAM were continued for grade 3 neutropenia and grade 2 anorexia. The tumor and LNs partially responded, and the ascites disappeared. With this dosage and administration schedule, the partial response(PR)was maintained for approximately 8 months without any severe adverse reactions. This successful case might indicate that it is important for elderly patients with gastric cancer that progressed with prior chemotherapy regimens to consider appropriate reduction of the PTX dosage, schedule, and continuation of RAM.
authors.affiliation: Dept. of Surgery, Sakai City Medical Center.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Makari
authors.forename: Johta
authors.initials: J
authors.lastname: Mikami
authors.forename: Junpei
authors.initials: J
authors.lastname: Yoshimura
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inoue
authors.forename: Genta
authors.initials: G
authors.lastname: Sawada
authors.forename: Shin
authors.initials: S
authors.lastname: Nakahira
authors.forename: Jun
authors.initials: J
authors.lastname: Yamamura
authors.forename: Shunji
authors.initials: S
authors.lastname: Kamigaki
authors.forename: Ken
authors.initials: K
authors.lastname: Nakata
authors.forename: Tameyoshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Ikeda
authors.forename: Masaki
authors.initials: M
authors.lastname: Tsujie
authors.forename: Junya
authors.initials: J
authors.lastname: Fujita
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohzato
mesh_terms: D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D000096662:Ramucirumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D017239:Paclitaxel; D000096662:Ramucirumab