title: [Neuroprotection therapy of multiple sclerosis with high doses of ethylmethylhydroxypyridine succinate].
abstract: OBJECTIVE
  To study the therapeutic action of ethylmethylhydroxypyridine succinate (mexidol) on the neurodegeneration in multiple sclerosis (MS).
  
  
  METHODS
  Fifty-two MS patients and 24 healthy controls were examined using DTI MRI with tractography.
  
  
  CONCLUSIONS
  Ethylmethylhydroxypyridine succinate can prevent the progression of neurodegenerative processes in MS. However, further clinical trials are needed to confirm the results obtained in this study.
authors.affiliation: Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Prakhova
authors.affiliation: Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Ilves
authors.affiliation: Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: Zh I
authors.initials: ZI
authors.lastname: Savintceva
authors.affiliation: Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: K K
authors.initials: KK
authors.lastname: Mineev
authors.affiliation: Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: I G
authors.initials: IG
authors.lastname: Nikiforova
authors.affiliation: Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Rubanik
authors.affiliation: Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Kataeva
mesh_terms: D016022:Case-Control Studies; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000066829:Neuroprotection; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010847:Picolines; D011725:Pyridines / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D010847:Picolines; D011725:Pyridines; C517040:ethylmethylhydroxypyridine succinate; C070020:emoxypine succinate