title: Ocular promoting activity of grape polyphenols-A review.
abstract: The eye is a sensitive organ with complex optical system involves in the perception of light. Although it has several protective mechanisms by itself, various physiological and metabolic disorders are detrimental to the proper functioning of the visual system. Grape juice has long been used worldwide for its potent medicinal values including ocular promotion. Bioactivities of grape products are highly attributed to the presence of health promoting phytochemicals in them. Some phytochemicals present in the grape juice have been involved in the maintenance of intra-ocular pressure, regulation of glucose metabolisms and suppression of pro-inflammatory cytokines in the system. Particularly, the grape derived phytochemicals involve in minimizing various eye defects such as macular degradation, uvea, cataract formation, red eye, diabetic retinopathy and so on. However, only limited number of studies has been conducted so far focusing the ocular promoting activity of grape polyphenols. In this review, we discuss the role of grape polyphenols in ocular promotion relating their anti-oxidant, anti-microbial, anti-aging, anti-hypertensive and anti-inflammatory properties.
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea.
authors.forename: Sithranga Boopathy
authors.initials: SB
authors.lastname: Natarajan
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea; Nokyong Research Centre, Konkuk University, Chungju 380-701, Republic of Korea.
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Hwang
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea; Nokyong Research Centre, Konkuk University, Chungju 380-701, Republic of Korea.
authors.forename: Yon-Suk
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea; Nokyong Research Centre, Konkuk University, Chungju 380-701, Republic of Korea.
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea; Nokyong Research Centre, Konkuk University, Chungju 380-701, Republic of Korea. Electronic address: parkpj@kku.ac.kr.
authors.forename: Pyo-Jam
authors.initials: PJ
authors.lastname: Park
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D005123:Eye / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols / Q000494:pharmacology*; D027843:Vitis / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D000975:Antioxidants; D010936:Plant Extracts; D059808:Polyphenols
keywords: Diabetes; Eye disease; Grape polyphenols; Hypertension; Ocular promotion