title: Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 Diabetes.
abstract: The association between type 2 diabetes mellitus (T2DM) and systemic inflammation may increase platelet reactivity and the accelerated development of vascular disease. Platelets are able to modulate the function of immune cells via the direct release of growth factors and pro-inflammatory chemokines through the production of microvesicles. The microvesicles trigger a transcellular delivery system of bioactive molecules to other cells acting as vectors in the exchange of biological information. Here, we consider the influence of platelets and platelet-derived microvesicles on cells of the immune system and the implications in the pathogenesis of T2DM.
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Nancy
authors.initials: N
authors.lastname: Cortez-Espinosa
authors.affiliation: Department of Investigation Medicine-UNAM-UABJO, Faculty of School of Medicine, UABJO University, CP 60120, Oaxaca, Mexico.
authors.forename: Laura Perez-Campos
authors.initials: LP
authors.lastname: Mayoral
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Perez-Campos
authors.affiliation: Cardiovascular & Metabolic Diseases Program Duke-NUS Graduate Medical School Singapore, Singapore.
authors.forename: Hector Alejandro
authors.initials: HA
authors.lastname: Cabrera Fuentes
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Eduardo Perez-Campos
authors.initials: EP
authors.lastname: Mayoral
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Ruth
authors.initials: R
authors.lastname: Martínez-Cruz
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Socorro Pina
authors.initials: SP
authors.lastname: Canseco
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Gabriel Mayoral
authors.initials: GM
authors.lastname: Andrade
authors.affiliation: Unidad de Bioquímica e Inmunología, ITO-UNAM, Oaxaca, Mexico.
authors.forename: Margarito Martinez
authors.initials: MM
authors.lastname: Cruz
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Itandehui Gallegos
authors.initials: IG
authors.lastname: Velasco
authors.affiliation: Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
authors.forename: Pedro Hernandez
authors.initials: PH
authors.lastname: Cruz
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001792:Blood Platelets / Q000276:immunology* / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000276:immunology* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000097:blood / Q000276:immunology; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D018836:Inflammation Mediators
keywords: Platelets; diabetes; effectors; immune; inflammation; microvesicles