title: Randomized Controlled Trial Comparing the Effects of 2 Analgesic Drug Protocols in Patients who Received 5 Dental Implants.
abstract: OBJECTIVE
  This randomized controlled trial compares postoperative pain and swelling after placing dental implants in patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) versus NSAIDs and corticosteroids.
  
  
  METHODS
  Thirty patients received 5 dental implants each in the interforaminal region of the mandible. All patients were treated with ketorolac tromethamine 10 mg, 2 tablets daily for 2 days and amoxicillin 500 mg, 3 tablets daily for 7 days starting 24 hours before surgery. Experimental patients received an im injection of betamethasone 2 mL within 10 hours after surgery. Pain perception, intraoral inflammation (InIn), and extraoral inflammation (ExIn) data were collected 3, 7, and 14 days after surgery. Patients filled out a pain visual analog scale. InIn and ExIn were recorded by observing the existence of 7 signs.
  
  
  RESULTS
  One patient was excluded from control group. Pain perception, InIn, and ExIn were not different between groups at each time point. However, these variables were different from the previous time point within each group.
  
  
  CONCLUSIONS
  This study suggests that there is no difference in managing postoperative pain and swelling with betamethasone versus betamethasone and ketorolac.
authors.affiliation: *Professor and Chair, Biophysics Department, College of Dentistry, University del Salvador/Argentinean Dental Association (USAL/AOA), Buenos Aires, Argentina; Assistant Professor, Oral Implantology Program, College of Dentistry, USAL/AOA, Buenos Aires, Argentina. †Assistant Professor, Periodontology Department, College of Dentistry, University del Salvador/Argentinean Dental Association (USAL/AOA), Buenos Aires, Argentina. ‡Emeritus Professor, Dental Materials Department, College of Dentistry, University of Buenos Aires, Buenos Aires, Argentina; Professor, Post-Graduate Department, USAL/AOA, Buenos Aires, Argentina. §Director and Professor, Oral Implantology Program, College of Dentistry, University del Salvador/Argentinean Dental Association (USAL/AOA), Buenos Aires, Argentina.
authors.forename: Isaac Fernando
authors.initials: IF
authors.lastname: Meta
authors.forename: Miriam
authors.initials: M
authors.lastname: Bermolen
authors.forename: Ricardo
authors.initials: R
authors.lastname: Macchi
authors.forename: Jorge
authors.initials: J
authors.lastname: Aguilar
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001623:Betamethasone / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control; D005260:Female; D006801:Humans; D020911:Ketorolac Tromethamine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015921:Dental Implants; D020911:Ketorolac Tromethamine; D000658:Amoxicillin; D001623:Betamethasone