title: Comparison of the efficacy of four endobronchial ablation techniques in dogs.
abstract: The present study aimed to evaluate the safety and efficacy of four commonly used ablation techniques, namely neodymium-doped yttrium aluminium garnet (Nd:YAG) laser therapy, argon plasma coagulation (APC), high-frequency electrocautery and CO2cryotherapy. The techniques were performed at various powers or impedance settings, and for various durations, on the trachea of beagle dogs. Pathological changes of the tracheal wall were assessed by bronchoscopy. The endoscopic gross appearance of lesions induced by ablation treatments was consistent with the histopathological changes. The results suggested that cryotherapy was relatively safe, whereas APC induced superficial tissue coagulative necrosis. Furthermore, Nd:YAG laser therapy was the most efficient technique and showed the greatest penetration potential. In general, tissue injury was exacerbated with extended application time, at constant power or impedance. The safest application parameters were 20 W for ≤1 sec for Nd:YAG laser therapy, 40 W for ≤3 sec for electrocautery, 40 W for ≤5 sec for APC and 100 Ω for ≤120 sec for cryotherapy. At the maximum times, these settings resulted in identical pathological changes. Healing of the lesions following ablation was achieved within 3 weeks. The Nd:YAG laser, APC, electrocautery and cryotherapy endobronchial ablation techniques differed according to their potential and limitations for application on the trachea. However, when applied at specific combinations of power or impedance and duration, they exhibited similar efficacies.
authors.affiliation: Department of Respiratory Medicine, Xiamen 174 Hospital, Xiamen, Fujian 361000, P.R. China; Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
authors.forename: Linrong
authors.initials: L
authors.lastname: Tong
authors.affiliation: Department of Respiratory Medicine, Yancheng City First People's Hospital, Yancheng, Jiangsu 224000, P.R. China.
authors.forename: Koudong
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Bai
keywords: CO2 cryotherapy; argon plasma coagulation; bronchoscopy; electrocautery; neodymium-doped yttrium aluminium garnet laser