title: The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography.
abstract: Purification by flash chromatography strongly impacts the greenness of a process. Unfortunately, due to the lack of the relevant literature data, very often this impact cannot be assessed thus preventing the comparison of the environmental factors affecting the syntheses. We developed a simple mathematical approach to evaluate the minimum mass intensity of flash chromatography from the retention factor values determined by thin-layer chromatography.
authors.affiliation: Université Paris Sud, ICMMO, UMR CNRS 8182, Bâtiment 420, 91405 Orsay Cedex, France.
authors.forename: Freddy
authors.initials: F
authors.lastname: Pessel
authors.affiliation: Université de Cergy-Pontoise, LCB, EA 4505, 5 mail Gay-Lussac, Neuville sur Oise, 95031 Cergy-Pontoise, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Augé
authors.affiliation: Université Paris Sud, ICMMO, UMR CNRS 8182, Bâtiment 420, 91405 Orsay Cedex, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Billault
authors.affiliation: Université Paris Sud, ICMMO, UMR CNRS 8182, Bâtiment 420, 91405 Orsay Cedex, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Scherrmann
keywords: environmental factor; flash chromatography; green metrics; mass intensity; purification