title: Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease.
abstract: A series of [Re(i)L(CO)3]+complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia. p.barnard@latrobe.edu.au.
authors.forename: Chung Ying
authors.initials: CY
authors.lastname: Chan
authors.affiliation: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Asif
authors.initials: A
authors.lastname: Noor
authors.affiliation: Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Catriona A
authors.initials: CA
authors.lastname: McLean
authors.affiliation: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Donnelly
authors.affiliation: Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia. p.barnard@latrobe.edu.au.
authors.forename: Peter J
authors.identifier: http://orcid.org/0000-0003-1755-7991
authors.initials: PJ
authors.lastname: Barnard
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D056831:Coordination Complexes / Q000737:chemistry*; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008856:Microscopy, Fluorescence / Q000379:methods*; D008958:Models, Molecular; D061848:Optical Imaging / Q000379:methods; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D012211:Rhenium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D008024:Ligands; C030011:carbene; D012211:Rhenium; D008697:Methane