title: Influence of immunologic status on age prediction using signal joint T cell receptor excision circles.
abstract: Age estimation based on quantifying signal joint T cell receptor excision circle (sjTREC) in T cells has been established to be a promising approach in forensic practice and demonstrated in different ethnic groups. Considering that the homeostasis of T cells carrying sjTRECs is closely related to the immunologic status of a person, it is important to investigate the influence of various immunologic statuses on the age estimation model. In this study, quantification of sjTREC contents was performed for groups of people with various immune system statuses, and the result showed less correlation with chronological age (r2= 0.424) than in the healthy group (r2= 0.648). The simulation model indicated that this influence could increase the range of prediction in the age estimation model, and the mean absolute deviation (MAD) between chronological age and predicted age. Through this study, it was demonstrated that immunologic status is a factor that affects the accuracy of age prediction using sjTREC quantification.
authors.affiliation: Institute of Forensic Science, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
authors.forename: Sohee
authors.initials: S
authors.lastname: Cho
authors.affiliation: Department of Forensic Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Seo
authors.affiliation: Department of Forensic Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Institute of Forensic Science, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Kim
authors.affiliation: Institute of Forensic Science, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. sdlee@snu.ac.kr.|Department of Forensic Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. sdlee@snu.ac.kr.
authors.forename: Soong Deok
authors.initials: SD
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D002648:Child; D015329:Gene Rearrangement, T-Lymphocyte / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000032:analysis* / Q000235:genetics; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D011948:Receptors, Antigen, T-Cell
keywords: Age estimation; Immunologic status; Korean; Signal joint T cell receptor excision circles