title: Dorsal striatum D1-expressing neurons are involved with sensorimotor gating on prepulse inhibition test.
abstract: Prepulse inhibition (PPI) is a behavioral test in which the startle reflex response to a high-intensity stimulus (pulse) is inhibited by the prior presentation of a weak stimulus (prepulse). The classic neural circuitry that mediates startle response is localized in the brainstem; however, recent studies point to the contribution of structures involved in higher cognitive functions in regulating the sensorimotor gating, particularly forebrain regions innervated by dopaminergic nuclei. The aim of the present study was to verify the role of dorsal striatum (DS) and dopaminergic transmitting mediated by D1 and D2 receptors on PPI test in rats. DS inactivation induced by muscimol injection did not affect PPI (%PPI and startle response), although it impaired the locomotor activity and caused catalepsy. Infusion of D1-like antagonist SCH23390 impaired %PPI but did not disturb the startle response and locomotor activity evaluated immediately after PPI test. D2 antagonist microinjection (sulpiride) did not affect %PPI and startle response, but impaired motor activity. These results point to an important role of DS, probably mediated by direct basal ganglia pathway, on modulation of sensorimotor gating, in accordance with clinical studies showing PPI deficits in schizophrenia, Tourette syndrome, and compulsive disorders - pathologies related to basal ganglia dysfunctions.
authors.affiliation: Centro de Matemática Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, Brazil.
authors.forename: Samanta
authors.initials: S
authors.lastname: Rodrigues
authors.affiliation: Centro de Matemática Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Salum
authors.affiliation: Centro de Matemática Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, Brazil.
authors.forename: Tatiana L
authors.initials: TL
authors.lastname: Ferreira
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists / Q000494:pharmacology; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D065808:Prepulse Inhibition / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology; D055139:Sensory Gating / Q000187:drug effects / Q000502:physiology*; D066148:Spinal Cord Dorsal Horn / Q000187:drug effects / Q000378:metabolism*
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C534628:SCH 23390; D004298:Dopamine
keywords: Dopamine; SCH23390; Wistar rat; muscimol; prepulse inhibition; sulpiride