title: Response to Pembrolizumab in a Patient With Chemotherapy Refractory Bladder Cancer With Small Cell Variant Histology: A Case Report and Review of the Literature.
authors.affiliation: Department of Medical Oncology, Sidney Kimmel Cancer Center, Jefferson University Hospital, Philadelphia, PA.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Wilde
authors.affiliation: Foundation Medicine, Cambridge, MA.
authors.forename: Siraj M
authors.initials: SM
authors.lastname: Ali
authors.affiliation: Department of Surgical Pathology, Thomas Jefferson University Hospital, Philadelphia, PA.
authors.forename: Charalambos C
authors.initials: CC
authors.lastname: Solomides
authors.affiliation: Foundation Medicine, Cambridge, MA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Ross
authors.affiliation: Department of Urology, Thomas Jefferson University Hospital, Philadelphia, PA.
authors.forename: Edouard
authors.initials: E
authors.lastname: Trabulsi
authors.affiliation: Department of Medical Oncology, Sidney Kimmel Cancer Center, Jefferson University Hospital, Philadelphia, PA. Electronic address: jean.hoffman-censits@jefferson.edu.
authors.forename: Jean
authors.initials: J
authors.lastname: Hoffman-Censits
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000074322:Antineoplastic Agents, Immunological / Q000627:therapeutic use*; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000074322:Antineoplastic Agents, Immunological; C582435:pembrolizumab
keywords: Genomic profiling; Immunotherapy; PD-1 inhibitor; Small-cell carcinoma of the bladder; Variant histology