title: Serum C-reactive protein predicts early mortality in hospitalized patients with HBV-related decompensated cirrhosis.
abstract: The serum C-reactive protein (CRP) is an inflammatory marker. The aim of the present study was to elucidate whether CRP could serve as a potential surrogate marker for 30-day mortality in hospitalized patients with HBV-related decompensated cirrhosis (HBV-DeCi).This was a retrospective cohort study that included 140 patients with HBV-DeCi. All patients were followed up for 1-month. A panel of clinical and biochemical variables were analyzed for potential associations with outcomes using multiple regression models.The serum CRP was significantly higher in nonsurviving patients than in surviving patients. Multivariate analysis demonstrated that CRP levels (odds ratio: 1.047, P = 0.002) and the model for end-stage liver disease score (odds ratio: 1.370, P = 0.001) were independent predictors for mortality.Serum CRP is a simple marker that may serve as an additional predictor of 1-month mortality in hospitalized patients with HBV-DeCi.
authors.affiliation: Department of Ultrasonography, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Department of Clinical Laboratory, The Sixth Affiliated Hospital of Xinjiang Medical University, Xinjiang Department of Clinical Laboratory, The People's Hospital of Xinjiang Uygur Autonomous Region, Tianshan District, Urumqi Department of Clinical Laboratory Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: ShaoMing
authors.initials: S
authors.lastname: Zhu
authors.forename: Yulituzi
authors.initials: Y
authors.lastname: Waili
authors.forename: XiaoTing
authors.initials: X
authors.lastname: Qi
authors.forename: YueMei
authors.initials: Y
authors.lastname: Chen
authors.forename: YuFeng
authors.initials: Y
authors.lastname: Lou
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000401:mortality* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein