title: Do mesothelin/MUC16 interactions facilitate adenocarcinoma metastases to intracranial meningiomas?
abstract: BACKGROUND
  Meningiomas have been shown to express mesothelin, a high affinity binding site for MUC16, a transmembrane protein on adenocarcinoma cells. The mechanisms underlying adenocarcinoma metastases to meningiomas may provide insight into tumor-to-tumor metastases and adenocarcinoma metastases to leptomeningeal cells.
  
  
  METHODS
  Two meningiomas containing metastases from adenocarcinomas were identified and evaluated immunohistochemically for the expression and localization of mesothelin and MUC16.
  
  
  RESULTS
  Both meningiomas show extensive mesothelin immunoreactivity, and the adenocarcinomas metastatic to the meningiomas show mesothelin and MUC16 immunoreactivity at the interface with meningioma.
  
  
  CONCLUSIONS
  Interactions between MUC16 and/or mesothelin on the cell membrane of adenocarcinoma cells with mesothelin on meningioma cells may facilitate adenocarcinoma metastases to meningiomas and possibly the leptomeninges.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, India.
authors.forename: Mahlon D
authors.initials: MD
authors.lastname: Johnson
keywords: MUC16; Meningiona; mesothelin; metastasis; tumor-to-tumor