title: Effect of radiographic contrast media on renal perfusion - First results.
abstract: BACKGROUND
  Intra-arterial administration of radiographic contrast media (CM) is discussed to impair renal perfusion. The pathogenesis of contrast-induced Nephropathy (CIN) is still not clarified.
  
  
  OBJECTIVE
  This trial was performed to prove the effects of two CM with different molecular structure on renal perfusion.
  
  
  METHODS
  A prospective, randomized study on 16 pigs was designed to compare the outcome after application of a low-osmolar iodinated CM (770 mOsm/kg H2O - Group1) and an iso-osmolar iodinated CM (290 mOsm/kg H2o - Group2).Color Coded Doppler Sonography (LOGIQ E9, GE, Milwaukee, USA) was applied for measuring the Renal Resistive Index (RRI) before and after the first, fifth, and tenth bolus of CM. Statistics was performed using analysis of variance for repeated measurements with the Factor "CM".
  
  
  RESULTS
  All flow spectra were documented free of artifacts and Peak Systolic Velocity (PSV), Enddiastolic Velocity (EDV) and RRI respectively could be calculated. Mean PSV in Group 1 led to a decrease while in Group 2 PSV showed a significant increase after CM (p = 0,042). The course of the mean EDV in both groups deferred accordingly (p = 0,033). Mean RRI over time significantly deferred in both groups (p = 0,001). It showed a biphasic course in Group 2 and a decrease over time in Group 2.
  
  
  CONCLUSIONS
  While iso-osmolar CM induced an increase of PSV and EDV together with a decrease of RRI, low-osmolar CM could not show this effect or rather led to the opposite.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Lamby
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Jung
authors.affiliation: Department of Plastic and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Falter
authors.affiliation: Institute for Heart and Circulation Research, Eißendorfer Pferdeweg, Hamburg-Harburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Mrowietz
authors.affiliation: Department of Plastic and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Graf
authors.affiliation: Department of Anesthesiology, University of Regensburg, Regensburg, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Schellenberg
authors.affiliation: Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Platz Batista da Silva
authors.affiliation: Department of Plastic and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Prantl
authors.affiliation: Department of Biomaterials, Central Institute for Biomedical Engineering, University of Ulm, Ulm, Germany.
authors.forename: R P
authors.initials: RP
authors.lastname: Franke
authors.affiliation: Department of Anesthesiology, University of Regensburg, Regensburg, Germany.
authors.forename: E M
authors.initials: EM
authors.lastname: Jung
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003287:Contrast Media / Q000627:therapeutic use*; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced*; D006801:Humans; D007668:Kidney / Q000528:radiation effects*; D011446:Prospective Studies; D013552:Swine
chemical_list: D003287:Contrast Media
keywords: CCDS; CIN; Renal perfusion; color coded Doppler sonography; contrast agent; contrast-induced Nephropathy; radiographic contrast media