title: Intraperitoneal free cancer cells in gastric cancer: pathology of peritoneal carcinomatosis and rationale for intraperitoneal chemotherapy/hyperthermic intraperitoneal chemotherapy in gastric cancer.
abstract: Peritoneal carcinomatosis (PC) is one of the most common causes of death in gastric cancer patients. Intraperitoneal free cancer cells (IFCCs) play a very important role in forming PC, but the administration of intraperitoneal chemotherapy (IPC) and/or hyperthermic intraperitoneal chemotherapy (HIPEC) could be an effective treatment for IFCCs. This review focuses on the origin of IFCCs, the mechanism of PC formatting, the rationale of IPC/HIPEC, and the current clinical trials on IPC/HIPEC to treat advanced gastric cancer patients.
authors.affiliation: Department of Peritoneal Cancer Surgery, Cancer Center of Beijing Shijitan Hospital affiliated to the Capital Medical University, Beijing 100038, China.
authors.forename: Zhong-He
authors.initials: ZH
authors.lastname: Ji
authors.affiliation: Department of Peritoneal Cancer Surgery, Cancer Center of Beijing Shijitan Hospital affiliated to the Capital Medical University, Beijing 100038, China.
authors.forename: Kai-Wen
authors.initials: KW
authors.lastname: Peng
authors.affiliation: Department of Peritoneal Cancer Surgery, Cancer Center of Beijing Shijitan Hospital affiliated to the Capital Medical University, Beijing 100038, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
keywords: Intraperitoneal free cancer cells (IFCCs); gastric cancer (GC); hyperthermic intraperitoneal chemotherapy (HIPEC); intraperitoneal chemotherapy (IPC); peritoneal carcinomatosis (PC)