title: Microarray Analysis of Hypertension.
abstract: Hypertension is a complex disorder in which multiple genes, pathways, and organ systems simultaneously interact to contribute to the final level of blood pressure. Fully elucidating these interactions is an important area of hypertension research and one in which high-throughput methods such as microarrays can play a key role. With recent advances in microarray technology, reliable and accurate quantification of all known mRNA transcripts in a sample is now routinely performed. In addition, with improved statistical methods and publicly available tools and resources, robust analysis of the large amount of data generated from microarray experiments is now achievable for all research laboratories as will be outlined in this review.
authors.affiliation: Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 375 Newton Road, 3181 MERF, Iowa City, IA, 52242, USA.
authors.forename: Henry L
authors.initials: HL
authors.lastname: Keen
authors.affiliation: Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 375 Newton Road, 3181 MERF, Iowa City, IA, 52242, USA. curt-sigmund@uiowa.edu.
authors.forename: Curt D
authors.initials: CD
authors.lastname: Sigmund
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D019295:Computational Biology; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D012333:RNA, Messenger
keywords: Bioinformatics; Blood pressure; Computational biology; Gene expression; Hypertension; Microarrays; mRNA