title: Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report.
abstract: BACKGROUND
  Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern.
  
  
  METHODS
  We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract.
  
  
  METHODS
  From 1996 to 2016, this patient was diagnosed with a high grade cervical intraepithelial neoplasia; a HR-HPV positive inguinal lymph node metastasis from clinically undetectable primary squamous cell carcinoma; a HPV-related vulvar high-grade squamous intraepithelial lesion and an invasive squamous cell carcinoma of the anus.
  
  
  METHODS
  All the intraepithelial and invasive lesions detected were properly treated, and subsequent follow up visits with gynecologic examination, anoscopy, pap smear and anal cytology were performed.
  
  
  RESULTS
  After a recurrence of the anal cancer and a subsequent salvage surgery with abdominoperineal resection, at the last available follow up visit no sign of disease recurrence was found.
  
  
  CONCLUSIONS
  This case stresses the importance of an accurate multidisciplinary follow-up in HIV-positive patients, including not only the routine medical, immunological, and virological evaluation, but also a periodical complete examination of the anogenital tract with cervicovaginal and anal cytology, colposcopy, high resolution anoscopy, and vulvar examination.
authors.affiliation: Gynecological Oncology Unit Pathology Unit Medical Oncology Radiotherapy Unit, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Clemente
authors.forename: Lara
authors.initials: L
authors.lastname: Alessandrini
authors.forename: Emanuela
authors.initials: E
authors.lastname: Vaccher
authors.forename: Antonino
authors.initials: A
authors.lastname: De Paoli
authors.forename: Monica
authors.initials: M
authors.lastname: Buttignol
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Canzonieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Sopracordevole
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D001005:Anus Neoplasms / Q000821:virology*; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D060085:Coinfection; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006689:Hodgkin Disease / Q000821:virology; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000821:virology*; D009382:Neoplasms, Unknown Primary / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000821:virology*