title: Wearable near-infrared optical probe for continuous monitoring during breast cancer neoadjuvant chemotherapy infusions.
abstract: We present a new continuous-wave wearable diffuse optical probe aimed at investigating the hemodynamic response of locally advanced breast cancer patients during neoadjuvant chemotherapy infusions. The system consists of a flexible printed circuit board that supports an array of six dual wavelength surface-mount LED and photodiode pairs. The probe is encased in a soft silicone housing that conforms to natural breast shape. Probe performance was evaluated using tissue-simulating phantoms and in vivo normal volunteer measurements. High SNR (71 dB), low source-detector crosstalk ( ? 60 ?? dB ), high measurement precision (0.17%), and good thermal stability (0.22% V rms / ° C ) were achieved in phantom studies. A cuff occlusion experiment was performed on the forearm of a healthy volunteer to demonstrate the ability to track rapid hemodynamic changes. Proof-of-principle normal volunteer measurements were taken to demonstrate the ability to collect continuous in vivo breast measurements. This wearable probe is a first of its kind tool to explore prognostic hemodynamic changes during chemotherapy in breast cancer patients.
authors.affiliation: Boston University, Department of Electrical and Computer Engineering and Photonics Center, 8 Saint Mary's Street, Boston, Massachusetts 02215, United States.
authors.forename: Fei
authors.initials: F
authors.lastname: Teng
authors.affiliation: Boston University, Fraunhofer Center for Manufacturing Innovation, 15 Saint Mary's Street, Brookline, Massachusetts 02446, United States.
authors.forename: Timothy
authors.initials: T
authors.lastname: Cormier
authors.affiliation: Boston University, Fraunhofer Center for Manufacturing Innovation, 15 Saint Mary's Street, Brookline, Massachusetts 02446, United States.
authors.forename: Alexis
authors.initials: A
authors.lastname: Sauer-Budge
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
authors.forename: Rachita
authors.initials: R
authors.lastname: Chaudhury
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
authors.forename: Vivian
authors.initials: V
authors.lastname: Pera
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
authors.forename: Raeef
authors.initials: R
authors.lastname: Istfan
authors.affiliation: Boston University, Fraunhofer Center for Manufacturing Innovation, 15 Saint Mary's Street, Brookline, Massachusetts 02446, United States.
authors.forename: David
authors.initials: D
authors.lastname: Chargin
authors.affiliation: Boston University, Fraunhofer Center for Manufacturing Innovation, 15 Saint Mary's Street, Brookline, Massachusetts 02446, United States.
authors.forename: Samuel
authors.initials: S
authors.lastname: Brookfield
authors.affiliation: Boston Medical Center, Section of Hematology and Oncology, Women's Health Unit, 801 Massachusetts Avenue, First Floor, Boston, Massachusetts 02118, United States.
authors.forename: Naomi Yu
authors.initials: NY
authors.lastname: Ko
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
authors.forename: Darren M
authors.initials: DM
authors.lastname: Roblyer
mesh_terms: D001940:Breast / Q000502:physiology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D020360:Neoadjuvant Therapy / Q000379:methods*; D019047:Phantoms, Imaging; D000076251:Wearable Electronic Devices