title: An enyne cycloisomerization/[5+1] reaction sequence to synthesize tetrahydroisoquinolinones from enyne-enes and CO.
abstract: An enyne cycloisomerization/[5+1] reaction sequence was developed to synthesize tetrahydroisoquinolinones from linear enyne-enes and CO. The first step is a gold(i)-catalyzed enyne cycloisomerization, generating six-membered-ring-fused vinylcyclopropanes. The second step is a rhodium(i)-catalyzed [5+1] reaction of vinylcyclopropanes with CO. This two-step reaction could also be carried out in one-pot without isolating the cycloisomerization product generated from the first step of this sequence.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, 100871, China. yuzx@pku.edu.cn.
authors.forename: Zhe
authors.identifier: http://orcid.org/0000-0001-6679-0496
authors.initials: Z
authors.lastname: Zhuang
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, 100871, China. yuzx@pku.edu.cn.
authors.forename: Chen-Long
authors.initials: CL
authors.lastname: Li
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, 100871, China. yuzx@pku.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, 100871, China. yuzx@pku.edu.cn.
authors.forename: Yu-Hao
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, 100871, China. yuzx@pku.edu.cn.
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Yu