title: Effects of aging upon the host response to implants.
abstract: Macrophage polarization during the host response is now a well-accepted predictor of outcomes following material implantation. Immunosenescence, dysregulation of macrophage function, and delayed resolution of immune responses in aged individuals have all been demonstrated, suggesting that host responses to materials in aged individuals should differ from those in younger individuals. However, few studies examining the effects of aging upon the host response have been performed. The present work sought to elucidate the impacts of aging upon the host response to polypropylene mesh implanted into 8-week-old and 18-month-old mice. The results showed that there are significant differences in macrophage surface marker expression, migration, and polarization during the early host macrophage response and delayed resolution of the host response in 18-month-old versus 8-week-old mice. These differences could not be attributed to cell-intrinsic defects alone, suggesting that the host macrophage response to implants is likely also dictated to a significant degree by the local tissue microenvironment. These results raise important questions about the design and testing of materials and devices often intended to treat aged individuals and suggest that an improved understanding of patient- and context-dependent macrophage responses has the potential to improve outcomes in aged individuals. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1281-1292, 2017.
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, Pennsylvania, 15219.|Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hachim
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, Pennsylvania, 15219.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, Pennsylvania, 15219.|Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.
authors.forename: Samuel T
authors.initials: ST
authors.lastname: Lopresti
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, Pennsylvania, 15219.|Department of Pathology, University of Pittsburgh School of Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, Pennsylvania, 15261.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Stahl
authors.affiliation: Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.
authors.forename: Yuta U
authors.initials: YU
authors.lastname: Umeda
authors.affiliation: Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.
authors.forename: Rahul D
authors.initials: RD
authors.lastname: Rege
authors.affiliation: Department of Chemical Engineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.
authors.forename: Sean T
authors.initials: ST
authors.lastname: Carey
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, Pennsylvania, 15219.
authors.forename: Deepa
authors.initials: D
authors.lastname: Mani
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, Pennsylvania, 15219.|Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.|Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, University of Pittsburgh, 300 Halket Street, Pittsburgh, Pennsylvania, 15213.
authors.forename: Bryan N
authors.initials: BN
authors.lastname: Brown
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D005260:Female; D005549:Foreign-Body Reaction / Q000378:metabolism* / Q000503:physiopathology; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D011126:Polypropylenes; D013526:Surgical Mesh
chemical_list: D011126:Polypropylenes
keywords: aging; host response; implant; macrophage; polarization