title: Lymphoepithelial carcinoma in parotid gland related to EBV infection: A case report.
abstract: Lymphoepithelial carcinoma commonly occurs at the nasopharynx and rarely occurs at other sites in the head and neck region. It is well known to occur at limited patients of local area as Asia or Arctic Circle. Related to this point, it is pointed out that this tumor has strong relation with Epstein-Barr Virus (EBV) infection. In this time, we experienced to treat lymphoepithelial carcinoma with metastatic cervical lymph nodes occurring at parotid gland. The morbidity ratio of this tumor is less than one percent of all parotid gland tumors. Moreover, we proved the infection of EBV to tumor cell by in situ hybridization (ISH). Incidentally, because it is considered that this tumor has well sensitivity against irradiation or anti-tumor drugs, prognosis of this tumor is better than that of other head and neck tumors with different pathological type. Actually, we tried to perform chemotherapy twice in (Nedaplatin (CDGP) 60mg/m2×day 2 and 5-FU 600mg/m2×day 5) and to irradiate about 70Gy dose against parotid gland and cervical lymph nodes. It could not find local recurrence or metastasis as of now after five years from treatment.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan. Electronic address: maeidahiroyuki@yahoo.co.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maeda
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamashiro
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Yukashi
authors.initials: Y
authors.lastname: Yamashita
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hirakawa
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Agena
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Uehara
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Sen
authors.initials: S
authors.lastname: Matayoshi
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D009333:Neck; D010306:Parotid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D010307:Parotid Neoplasms / Q000000981:diagnostic imaging / Q000821:virology*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: CCRT; EBV; In situ hybridization; Lymphoepithelial carcinoma; Parotid gland