title: Effects of periodontal treatment on exacerbation frequency and lung function in patients with chronic periodontitis: study protocol of a 1-year randomized controlled trial.
abstract: Chronic obstructive pulmonary disease (COPD) has been associated with periodontal disease (PD), and periodontal treatment (PT) has been connected to reduction of lung disease exacerbations. Bronchiectasis has many clinical similarities with COPD but, although it is also a chronic lung disease, to date it has not been studied with relation to PD. The aim of this study is to evaluate whether PT associated with photodynamic therapy (PDT) reduces the number of exacerbations, improves pulmonary function, periodontal clinical parameters and quality of life after 1 year of periodontal treatment follow-up.
  
  
  
  Bronchiectasis patients will undergo medical anamnesis and periodontal examination. Participants with periodontitis will be divided into two groups and PT will be performed as G1 control group (n = 32) - OHO (oral hygiene orientation) + supragingival treatment + simulation of using photodynamic therapy (PDT); G2 experimental (n = 32) - scaling and root planing + PDT + OHO. Lung function will be assessed both at baseline and after 1 year by spirometry, exacerbation history will be analyzed through clinical records monitoring. Three instruments for quality of life assessment will also be applied - Saint George's Respiratory Questionnaire and Impact Profile Analysis Oral health (OHIP-14). It is expected that periodontal treatment can improve the analyzed parameters after 1 year.
  
  
  
  Although only one study evaluates exacerbation in COPD after 1 year of PT, bronchiectasis has not been studied in the dentistry field to date.
  
  
  
  NCT02514226. Version #1. This study protocol receives grant from FAPESP (São Paulo Research Foundation) #2015/20535-1. First received: July 22, 2015, 1stversion. This protocol has been approved by the Research Ethics Committee of Nove de Julho University.
authors.affiliation: Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
authors.forename: Sergio dos Santos
authors.initials: SS
authors.lastname: Romero
authors.affiliation: Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, Vergueiro, 235/249, CEP 01504-001, São Paulo, Brazil.
authors.forename: Erika Horácio
authors.initials: EH
authors.lastname: Pinto
authors.affiliation: Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, Vergueiro, 235/249, CEP 01504-001, São Paulo, Brazil.
authors.forename: Priscila Larcher
authors.initials: PL
authors.lastname: Longo
authors.affiliation: Postgraduate program in Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
authors.forename: Simone
authors.initials: S
authors.lastname: Dal Corso
authors.affiliation: Postgraduate program in Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
authors.forename: Fernanda Cordoba
authors.initials: FC
authors.lastname: Lanza
authors.affiliation: Pulmonary Department, Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Stelmach
authors.affiliation: Pulmonary Department, Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Samia Zahi
authors.initials: SZ
authors.lastname: Rached
authors.affiliation: Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, Vergueiro, 235/249, CEP 01504-001, São Paulo, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Lino-Dos-Santos-Franco
authors.affiliation: Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Marcia Pinto Alves
authors.initials: MP
authors.lastname: Mayer
authors.affiliation: Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, Vergueiro, 235/249, CEP 01504-001, São Paulo, Brazil.|Postgraduate program in Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
authors.forename: Sandra Kalil
authors.initials: SK
authors.lastname: Bussadori
authors.affiliation: Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, Vergueiro, 235/249, CEP 01504-001, São Paulo, Brazil.|Postgraduate program in Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
authors.forename: Kristianne Porta Santos
authors.initials: KP
authors.lastname: Fernandes
authors.affiliation: Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, Vergueiro, 235/249, CEP 01504-001, São Paulo, Brazil.|Postgraduate program in Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
authors.forename: Raquel Agnelli
authors.initials: RA
authors.lastname: Mesquita-Ferrari
authors.affiliation: Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, Vergueiro, 235/249, CEP 01504-001, São Paulo, Brazil. annacrth@gmail.com.
authors.forename: Anna Carolina Ratto Tempestini
authors.initials: AC
authors.lastname: Horliana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D001987:Bronchiectasis / Q000150:complications* / Q000503:physiopathology*; D055113:Chronic Periodontitis / Q000628:therapy*; D012534:Dental Scaling; D018450:Disease Progression; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene / Q000379:methods; D010778:Photochemotherapy; D011788:Quality of Life; D012107:Research Design; D016745:Root Planing; D013147:Spirometry; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
keywords: Bronchiectasis; Dentistry; Periodontal disease; Periodontal treatment; Respiratory medicine