title: [Study of Breast Cancer Patients Diagnosed Preoperatively with Ductal Carcinoma In Situ].
abstract: Although ductal carcinoma in situ(DCIS)is generally cured by surgical resection, it has been suggested that resection is over-treatment for some patients with DCIS. The aim of this study was to reconsider operative indications for patients with DCIS by examining clinicopathological features of 23 patients who underwent surgical resection for DCIS in our institute over a single year. Postoperative histological examination revealed that there were Luminal and HER2-positive subtypes, but no triple negative cancers. We found coincidental invasive ductal carcinoma(IDC)in 5 patients, and in all 5 the tumor size exceeded 60 mm. There was no coincidence of IDC in patients with a Ki-67 index ≤5%. Positive surgical margins were observed in 7 patients, all of which were histologically diagnosed as DCIS. Only 1 of the 7 patients underwent additional surgical resection; the 6 remaining patients, including 2 patients who received no treatment, did not undergo additional resection. All patients including those with positive surgical margins have had a 5-year relapse-free survival. Our findings imply that the subgroup of DCIS patients without IDC could be followed up without surgery.
authors.affiliation: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
authors.forename: Masato
authors.initials: M
authors.lastname: Nakajima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nagahashi
authors.forename: Maiko
authors.initials: M
authors.lastname: Endo
authors.forename: Ayaka
authors.initials: A
authors.lastname: Otani
authors.forename: Junko
authors.initials: J
authors.lastname: Tsuchida
authors.forename: Kazuki
authors.initials: K
authors.lastname: Moro
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Niwano
authors.forename: Chie
authors.initials: C
authors.lastname: Toshikawa
authors.forename: Miki
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Mayuko
authors.initials: M
authors.lastname: Ikarashi
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tatsuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kameyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yu
authors.initials: Y
authors.lastname: Koyama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Wakai
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D055815:Young Adult