title: Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine.
abstract: Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in the form of ionic liquid species. The main aim of this Review is to attract a broad audience of chemical, biological, and medical scientists to study advantages of ionic liquid pharmaceutics. Overall, the discussed data highlight the importance of the research direction defined as "Ioliomics", studies of ions in liquids in modern chemistry, biology, and medicine.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , Leninsky prospect 47, Moscow 119991, Russia.
authors.forename: Ksenia S
authors.initials: KS
authors.lastname: Egorova
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , Leninsky prospect 47, Moscow 119991, Russia.
authors.forename: Evgeniy G
authors.initials: EG
authors.lastname: Gordeev
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , Leninsky prospect 47, Moscow 119991, Russia.|Department of Chemistry, Saint Petersburg State University , Stary Petergof 198504, Russia.
authors.forename: Valentine P
authors.identifier: http://orcid.org/0000-0002-6447-557X
authors.initials: VP
authors.lastname: Ananikov
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001673:Biodegradation, Environmental; D004339:Drug Compounding; D016503:Drug Delivery Systems; D052578:Ionic Liquids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012995:Solubility
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D052578:Ionic Liquids