title: From mitochondrial large amplitude swelling to the permeability transition - a short historic overview.
abstract: An outline of studies on the mitochondrial large conductance permeability pore is presented starting from the early observations in the 1950s on the large amplitude mitochondrial swelling, through the concept of the permeability transition and various theories on the structure of the related permeability transition pore, up to its present identification as a part of mitochondrial (F1FO) ATPase/ATP synthase.
authors.affiliation: Department of Biochemistry, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
authors.forename: Lech
authors.initials: L
authors.lastname: Wojtczak
authors.affiliation: Department of Biochemistry, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
authors.forename: Mariusz R
authors.initials: MR
authors.lastname: Więckowski
mesh_terms: D000818:Animals; D001671:Biochemistry / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D025261:Mitochondrial Proton-Translocating ATPases; D008933:Mitochondrial Swelling; D010539:Permeability
chemical_list: D025261:Mitochondrial Proton-Translocating ATPases
keywords: ATP synthase; mitochondria; permeability transition; pore; swelling