title: [A Patient with Colon Cancer Local Site Recurrence Who Experienced Difficulty Tolerating Intensive Chemotherapy Was Treated Effectively with sLV5FU2 Therapy].
abstract: An 82-year-old man underwent anterior resection for rectal cancer in 2006. Local recurrence was diagnosed 5 years and 4 months after the operation. He could not undergo intensive chemotherapy because of his age and health status(a history of tubercular and pancytopenia due to chronic hepatitis C). sLV5FU2 chemotherapy was initiated. The CEA level decreased immediately after chemotherapy, and a complete response was observed on CT. After 18 courses, chemotherapy was discontinued. A complete response was detected for 1 year after the chemotherapy holiday began. For patients who experience difficulty tolerating intensive chemotherapy, good outcomes have been achieved even if relatively light regimens are used. For elderly patients or those with several complications, we suggest selecting a regimen based on the QOL.
authors.affiliation: Dept. of Surgery, Nishinomiya Municipal Central Hospital.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Shinji
authors.initials: S
authors.lastname: Tokuyama
authors.forename: Shoko
authors.initials: S
authors.lastname: Honda
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yukimoto
authors.forename: Akina
authors.initials: A
authors.lastname: Saito
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Okada
authors.forename: Ken
authors.initials: K
authors.lastname: Konishi
authors.forename: Hideo
authors.initials: H
authors.lastname: Ota
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Miki
authors.forename: Kenji
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D002955:Leucovorin; D005472:Fluorouracil