title: UNC-Emory Infant Atlases for Macaque Brain Image Analysis: Postnatal Brain Development through 12 Months.
abstract: Computational anatomical atlases have shown to be of immense value in neuroimaging as they provide age appropriate reference spaces alongside ancillary anatomical information for automated analysis such as subcortical structural definitions, cortical parcellations or white fiber tract regions. Standard workflows in neuroimaging necessitate such atlases to be appropriately selected for the subject population of interest. This is especially of importance in early postnatal brain development, where rapid changes in brain shape and appearance render neuroimaging workflows sensitive to the appropriate atlas choice. We present here a set of novel computation atlases for structural MRI and Diffusion Tensor Imaging as crucial resource for the analysis of MRI data from non-human primate rhesus monkey (Macaca mulatta) data in early postnatal brain development. Forty socially-housed infant macaques were scanned longitudinally at ages 2 weeks, 3, 6, and 12 months in order to create cross-sectional structural and DTI atlases via unbiased atlas building at each of these ages. Probabilistic spatial prior definitions for the major tissue classes were trained on each atlas with expert manual segmentations. In this article we present the development and use of these atlases with publicly available tools, as well as the atlases themselves, which are publicly disseminated to the scientific community.
authors.affiliation: Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Yundi
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Kitware Inc. Carrboro, NC, USA.
authors.forename: Francois
authors.initials: F
authors.lastname: Budin
authors.affiliation: Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Eva
authors.initials: E
authors.lastname: Yapuncich
authors.affiliation: Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Rumple
authors.affiliation: Department of Psychiatry, University of North CarolinaChapel Hill, NC, USA; Department of Computer Science, University of North CarolinaChapel Hill, NC, USA.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Young
authors.affiliation: Division of Autism and Related Developmental Disabilities, Department of Pediatrics, Marcus Autism Center, Children's Healthcare of Atlanta, Emory School of Medicine Atlanta, GA, USA.
authors.forename: Christa
authors.initials: C
authors.lastname: Payne
authors.affiliation: Yerkes National Primate Research Center, Emory University Atlanta, GA, USA.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Bioengineering, University of California, Riverside Riverside, CA, USA.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.affiliation: Yerkes National Primate Research Center, Emory University Atlanta, GA, USA.
authors.forename: Jodi
authors.initials: J
authors.lastname: Godfrey
authors.affiliation: Department of Child Psychology, Institute of Child Development, University of Minnesota Minneapolis, MN, USA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Howell
authors.affiliation: Yerkes National Primate Research Center, Emory UniversityAtlanta, GA, USA; Department of Psychiatry and Behavioral Sciences, Emory UniversityAtlanta, GA, USA.
authors.forename: Mar M
authors.initials: MM
authors.lastname: Sanchez
authors.affiliation: Department of Psychiatry, University of North CarolinaChapel Hill, NC, USA; Department of Computer Science, University of North CarolinaChapel Hill, NC, USA.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Styner
keywords: automatic segmentation; computational atlases; diffusion tensor imaging; macaque; magnetic resonance imaging; neuroimaging; non-human primate; white matter pathways