title: A Facile, Improved Synthesis of Sildenafil and Its Analogues.
abstract: This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with infrared (IR), ¹H-NMR and13C-NMR spectroscopic methods, and high resolution mass spectroscopy (HRMS) analysis.
authors.affiliation: Aurobindo Pharma Limited Research Centre-II, Survey No. 71&72, Indrakaran Village, Sangareddy Mandal, Medak District 502329, Telangana, India. avraghavareddy@yahoo.com.|Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500085, Telangana, India. avraghavareddy@yahoo.com.
authors.forename: Ambati V
authors.initials: AV
authors.lastname: Raghava Reddy
authors.affiliation: Aurobindo Pharma Limited Research Centre-II, Survey No. 71&72, Indrakaran Village, Sangareddy Mandal, Medak District 502329, Telangana, India. srinivasgaraga@yahoo.com.
authors.forename: Garaga
authors.initials: G
authors.lastname: Srinivas
authors.affiliation: Aurobindo Pharma Limited Research Centre-II, Survey No. 71&72, Indrakaran Village, Sangareddy Mandal, Medak District 502329, Telangana, India. chandiran.t@aurobindo.com.
authors.forename: Chandiran
authors.initials: C
authors.lastname: Takshinamoorthy
authors.affiliation: Aurobindo Pharma Limited Research Centre-II, Survey No. 71&72, Indrakaran Village, Sangareddy Mandal, Medak District 502329, Telangana, India. badari_peruri@yahoo.com.
authors.forename: Badarinadh
authors.initials: B
authors.lastname: Gupta Peruri
authors.affiliation: Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500085, Telangana, India. andranaidu@gmail.com.
authors.forename: Andra
authors.initials: A
authors.lastname: Naidu
keywords: chlorosulfonation; novel analogues; sildenafil