title: The expression of insulin-like growth factor-1 in senior patients with diabetes and dementia.
abstract: This study was conducted to investigate the expression of insulin-like growth factor-1 (IGF-1) in elderly patients with diabetes and dementia and to analyze the expression mechanism. A total of 30 senior patients with diabetes and dementia (group A), 30 senior patients with dementia but no diabetes (group B), 30 senior patients with diabetes but no dementia (group C), and 30 healthy seniors (group D) were continuously selected. The ELISA method was used to test the level of serum IGF-1, β-amyloid peptide (Aβ) and the phosphorylation of immunohistochemical staining of microtubule associated protein (tau protein). Western blot analysis was utilized to test the level of prion protein (PrP), forkhead transcription factor O (FOXO) subfamily protein, p-PI3K and p-Akt. The levels of IGF-1, Aβ, tau protein positive rate, PrP, FOXO protein, p-PI3K, and p-Akt in group A were significantly higher than that in group B, which was higher than in groups C and D. The results between groups A and B, but not groups C and D, were statistically significant (P<0.05). IGF-1 was highly expressed in senior patients with diabetes and dementia. Thus, IGF-1 can adjust the expression of PrP and FOXO through p-PI3K/Akt pathway and further impact the formation of Aβ and tau protein, leading to dementia.
authors.affiliation: Department of Neurology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264003, P.R. China.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Linglong Yingcheng Hospital, Zhaoyuan, Shandong 265400, P.R. China.
authors.forename: Shu-Qing
authors.initials: SQ
authors.lastname: Liu
authors.affiliation: Department of Neurology, Affiliated Hospital of Heze Medical College, Heze, Shandong 274000, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yuan
authors.affiliation: Department of Geriatric Medicine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264003, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Lu
keywords: and PI3K/Akt; dementia; diabetes; forkhead transcription factor O; insulin-like growth factor-1; microtubule associated protein; prion protein; β-amyloid peptide