title: Evaluation of wrought Zn-Al alloys (1, 3, and 5 wt % Al) through mechanical and in vivo testing for stent applications.
abstract: Special high grade zinc and wrought zinc-aluminum (Zn-Al) alloys containing up to 5.5 wt % Al were processed, characterized, and implanted in rats in search of a new family of alloys with possible applications as bioabsorbable endovascular stents. These materials retained roll-induced texture with an anisotropic distribution of the second-phase Al precipitates following hot-rolling, and changes in lattice parameters were observed with respect to Al content. Mechanical properties for the alloys fell roughly in line with strength (190-240 MPa yield strength; 220-300 MPa ultimate tensile strength) and elongation (15-30%) benchmarks, and favorable elastic ranges (0.19-0.27%) were observed. Intergranular corrosion was observed during residence of Zn-Al alloys in the murine aorta, suggesting a different corrosion mechanism than that of pure zinc. This mode of failure needs to be avoided for stent applications because the intergranular corrosion caused cracking and fragmentation of the implants, although the composition of corrosion products was roughly identical between non- and Al-containing materials. In spite of differences in corrosion mechanisms, the cross-sectional reduction of metals in murine aorta was nearly identical at 30-40% and 40-50% after 4.5 and 6 months, respectively, for pure Zn and Zn-Al alloys. Histopathological analysis and evaluation of arterial tissue compatibility around Zn-Al alloys failed to identify areas of necrosis, though both chronic and acute inflammatory indications were present. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 245-258, 2018.
authors.affiliation: Department of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, 49931.
authors.forename: Patrick K
authors.initials: PK
authors.lastname: Bowen
authors.affiliation: Department of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, 49931.
authors.forename: Jan-Marten
authors.initials: JM
authors.lastname: Seitz
authors.affiliation: Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, 49931.
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Guillory
authors.affiliation: Department of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, 49931.
authors.forename: Jacob P
authors.initials: JP
authors.lastname: Braykovich
authors.affiliation: Department of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, 49931.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, 49931.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Goldman
authors.affiliation: Department of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, 49931.
authors.forename: Jaroslaw W
authors.initials: JW
authors.lastname: Drelich
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000535:Aluminum / Q000737:chemistry*; D000818:Animals; D001011:Aorta; D001807:Blood Vessel Prosthesis; D003343:Corrosion; D008422:Materials Testing; D051379:Mice; D015607:Stents; D013314:Stress, Mechanical; D015032:Zinc / Q000737:chemistry*
chemical_list: D000497:Alloys; D000535:Aluminum; D015032:Zinc
keywords: alloys; bioabsorbable stent; corrosion; histology; mechanical testing; zinc