title: Rare virilizing granulosa cell tumor in an adolescent.
abstract: Hormone-producing malignancies are rare in children or adolescent patients: Only 0.1% of all ovarian tumors and 4-5% of granulosa cell tumors occur in the sexually non-active ages. Granulosa cell tumors (GCTs) are sex cord-stromal tumors of the ovary, representing 7-8% of all ovarian neoplasms. A total of 95% of all GCTs are adult-type, and only 5% are diagnosed as juvenile-type GCT. A majority of children with juvenile-type GCT present with isosexual precocious pseudopuberty due to excessive estrogen production, although virilizing, testosterone-producing, juvenile-type GCTs are rare, occurring only in 2-3% of cases. The present case study reports on a case of a virilizing, juvenile-type GCT in a 14-year-old girl, along with a review of the literature.
authors.affiliation: Department of Obstetrics and Gynecology, Zala County Hospital, 8900 Zalaegerszeg, Hungary.
authors.forename: Dorottya
authors.initials: D
authors.lastname: Bús
authors.affiliation: Department of Neonatology and Pediatrics, Zala County Hospital, 8900 Zalaegerszeg, Hungary.
authors.forename: Mária
authors.initials: M
authors.lastname: Buzogány
authors.affiliation: Department of Radiology, Zala County Hospital, 8900 Zalaegerszeg, Hungary.
authors.forename: Gyöngyi
authors.initials: G
authors.lastname: Nagy
authors.affiliation: Department of Obstetrics and Gynecology, Zala County Hospital, 8900 Zalaegerszeg, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Vajda
keywords: adolescent; juvenile granulosa cell tumor; ovary; virilization