title: Addressing Unmet Clinical Needs with UV Bioadhesives.
abstract: The invasive practice of suturing for wound closure has persisted for millennia; with the rate of medical development, it is staggering that there are few viable alternatives to invasive mechanical fasteners. Biocompatible and biodegradable polymers are attractive candidates for versatile bioadhesives and could revolutionize surgical procedures. Bioadhesives can be broadly placed into two groups: activated and instant. Almost all commercially available bioadhesives are instant, which cross-link by mixing two components or on contact with moisture. Activated bioadhesives, on the other hand, allow control of when and where a bioadhesive cross-links and, in some cases, the extent of cross-linking. Despite significant progress, there has been little translation of activated bioadhesives to clinical use. This review discusses recent developments in UV-activated bioadhesives toward addressing unmet clinical needs.
authors.affiliation: Singapore University of Technology and Design , 8 Somapah Road, Singapore 487372.
authors.forename: Richard D
authors.initials: RD
authors.lastname: O'Rorke
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , Block N4.1, Nanyang Avenue, Singapore 639798.
authors.forename: Oleksandr
authors.initials: O
authors.lastname: Pokholenko
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , Block N4.1, Nanyang Avenue, Singapore 639798.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , Block N4.1, Nanyang Avenue, Singapore 639798.
authors.forename: Ting
authors.initials: T
authors.lastname: Cheng
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , Block N4.1, Nanyang Avenue, Singapore 639798.
authors.forename: Ankur
authors.initials: A
authors.lastname: Shah
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , Block N4.1, Nanyang Avenue, Singapore 639798.|Faculty of Dentistry, National University of Singapore , 11 Lower Kent Ridge Road, Singapore 119083.
authors.forename: Vishal
authors.initials: V
authors.lastname: Mogal
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , Block N4.1, Nanyang Avenue, Singapore 639798.
authors.forename: Terry W J
authors.identifier: 0000-0001-8596-9619
authors.initials: TW
authors.lastname: Steele
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D004195:Disease Models, Animal; D006801:Humans; D011108:Polymers / Q000737:chemistry; D014014:Tissue Adhesives / Q000737:chemistry* / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D014014:Tissue Adhesives