title: Dscam1 web server: online prediction of Dscam1 self- and hetero-affinity.
abstract: BACKGROUND
  Formation of homodimers by identical Dscam1 protein isomers on cell surface is the key factor for the self-avoidance of growing neurites. Dscam1 immense diversity has a critical role in the formation of arthropod neuronal circuit, showing unique evolutionary properties when compared to other cell surface proteins. Experimental measures are available for 89 self-binding and 1722 hetero-binding protein samples, out of more than 19 thousands (self-binding) and 350 millions (hetero-binding) possible isomer combinations.
  
  
  RESULTS
  We developed Dscam1 Web Server to quickly predict Dscam1 self- and hetero- binding affinity for batches of Dscam1 isomers. The server can help the study of Dscam1 affinity and help researchers navigate through the tens of millions of possible isomer combinations to isolate the strong-binding ones.
  
  
  METHODS
  Dscam1 Web Server is freely available at: http://bioinformatics.tecnoparco.org/Dscam1-webserver . Web server code is available at https://gitlab.com/ne1s0n/Dscam1-binding .
  
  
  BACKGROUND
  simone.marini@unipv.it or guangzhong.wang@picb.ac.cn.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.
authors.forename: Simone
authors.initials: S
authors.lastname: Marini
authors.affiliation: Council for Agricultural Research and Economics (CREA), Research Centre for Fodder Crops and Dairy Productions, Lodi, Italy.
authors.forename: Nelson
authors.initials: N
authors.lastname: Nazzicari
authors.affiliation: Department of Bioinformatics and Biostatistics, PTP Science Park, Lodi, Italy.|Faculty of Bioscience and Technology for Food, Agriculture and Environment, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Filippo
authors.initials: F
authors.lastname: Biscarini
authors.affiliation: Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Guang-Zhong
authors.initials: GZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules; D019295:Computational Biology / Q000379:methods*; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D055503:Protein Multimerization; D012984:Software
chemical_list: D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; C491736:Dscam1 protein, Drosophila; D019006:Neural Cell Adhesion Molecules