title: Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1Aligands.
abstract: The 5-hydroxytryptamine (5-HT1A) receptors represent an attractive target in drug discovery. In particular, 5-HT1Aagonists and partial agonists are deeply investigated for their potential role in the treatment of anxiety, depression, ischaemic brain disorder and more recently, of pain. On the other hand, 5-HT1Aantagonists have been revealed promising compounds in cognition disorders and, lately, in cancer. Thus, the discovery of 5HT1Aligands is nowadays an appealing research activity in medicinal chemistry. In this work, Comparative Molecular Fields Analysis (CoMFA) and Comparative Molecular Similarity Index Analysis (CoMSIA) were applied on an in-house library of 5-HT1Aligands bearing different chemical scaffolds in order to elucidate their affinity and selectivity for the target.Following this procedure, a number of structural modifications have been drawn for the development of much more effective 5-HT1AR ligands. [Formula: see text].
authors.affiliation: a Department of Pharmacy , University of Genoa , Genoa , Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Guariento
authors.affiliation: b Department of Life Sciences , University of Modena and Reggio Emilia , Modena , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Franchini
authors.affiliation: a Department of Pharmacy , University of Genoa , Genoa , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Tonelli
authors.affiliation: a Department of Pharmacy , University of Genoa , Genoa , Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Fossa
authors.affiliation: b Department of Life Sciences , University of Modena and Reggio Emilia , Modena , Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Sorbi
authors.affiliation: a Department of Pharmacy , University of Genoa , Genoa , Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Cichero
authors.affiliation: b Department of Life Sciences , University of Modena and Reggio Emilia , Modena , Italy.
authors.forename: Livio
authors.initials: L
authors.lastname: Brasili
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D058829:Serotonin 5-HT1 Receptor Antagonists; D044282:Receptor, Serotonin, 5-HT1A
keywords: 3D-QSAR; 5HT1A-ligands; Adrenoreceptor; CoMFA; CoMSIA