title: Different types of white matter hyperintensities in CADASIL: Insights from 7-Tesla MRI.
abstract: In Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), by contrast to sporadic cerebral small vessel disease related to age and hypertension, white matter hyperintensities (WMH) are frequently observed in the white matter of anterior temporal poles, external capsules, and superior frontal regions. Whether these WMH (specific WMH) differ from those observed in other white matter areas (nonspecific WMH) remains unknown. Twenty patients were scanned to compare specific and nonspecific WMH using high-resolution images and analyses of relaxation times (T1R: longitudinal relaxation time and T2*R: effective transversal relaxation time). Specific WMH were characterized by significantly longer T1Rand T2*R(T1R: 2309 ± 120 ms versus 2145 ± 138 ms; T2*R: 40 ± 5 ms versus 35 ± 5 ms, p < 0.001). These results were not explained by the presence of dilated perivascular spaces found in the close vicinity of specific WMH. They were not either explained by the normal regional variability of T1Rand T2*Rin the white matter nor by systematic imaging artifacts as shown by the study of 17 age- and sex-matched healthy controls. Our results suggest large differences in water content between specific and nonspecific WMH in CADASIL, supporting that mechanisms underlying WMH may differ according to their location.
authors.affiliation: 1 University Paris Diderot, Sorbonne Paris Cité, UMR-S 1161 INSERM, Paris, France.|2 DHU NeuroVasc Sorbonne Paris Cité, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: De Guio
authors.affiliation: 3 UNIRS, NeuroSpin, I2BM/DSV, CEA, Gif-sur-Yvette, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vignaud
authors.affiliation: 1 University Paris Diderot, Sorbonne Paris Cité, UMR-S 1161 INSERM, Paris, France.|2 DHU NeuroVasc Sorbonne Paris Cité, Paris, France.|4 AP-PH, Lariboisière Hosp., Department of neurology, F-75475, Paris, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Chabriat
authors.affiliation: 1 University Paris Diderot, Sorbonne Paris Cité, UMR-S 1161 INSERM, Paris, France.|2 DHU NeuroVasc Sorbonne Paris Cité, Paris, France.|4 AP-PH, Lariboisière Hosp., Department of neurology, F-75475, Paris, France.|5 UNIACT, NeuroSpin, I2BM/DSV, CEA, Gif-sur-Yvette, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Jouvent
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D046589:CADASIL / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: CADASIL; cerebral small vessel disease; dilated perivascular spaces; relaxometry; white matter hyperintensities