title: Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status.
abstract: The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an association of the Ser267Phe variant (rs2296651) with HBV infection status in Moroccan patients.
  
  
  
  Using a TaqMan 5' allelic discrimination assay, the Ser267Phe variant was genotyped in 286 chronic hepatitis B patients, 135 individuals with spontaneous clearance from HBV infection and 109 healthy controls negative for hepatitis B serological markers.
  
  
  
  In this cohort, we detected only wild-type genotype (S267S) in all groups. This polymorphism was not associated with the HBV infection status in Moroccan patients.
  
  
  
  The S267F variant is absent among Moroccans regardless of chronic HBV infection status.
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place Louis Pasteur, 20360, Casablanca, Morocco. sayeh.ezzikouri@pasteur.ma.
authors.forename: Sayeh
authors.initials: S
authors.lastname: Ezzikouri
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place Louis Pasteur, 20360, Casablanca, Morocco.|Cell Biology Department, Faculty of Sciences, Chouaib Doukkali University, El-Jadida, Morocco.
authors.forename: Hajar
authors.initials: H
authors.lastname: Chihab
authors.affiliation: Cell Biology Department, Faculty of Sciences, Chouaib Doukkali University, El-Jadida, Morocco.
authors.forename: Abdellah
authors.initials: A
authors.lastname: Elhabazi
authors.affiliation: Virology Unit, Immunovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
authors.forename: Lahcen
authors.initials: L
authors.lastname: Wakrim
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place Louis Pasteur, 20360, Casablanca, Morocco.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Benjelloun
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco; D029363:Organic Anion Transporters, Sodium-Dependent / Q000235:genetics*; D011110:Polymorphism, Genetic; D027981:Symporters / Q000235:genetics*; D044465:White People; D055815:Young Adult
chemical_list: D029363:Organic Anion Transporters, Sodium-Dependent; D027981:Symporters; C071908:sodium-bile acid cotransporter
keywords: Functional receptor; Hepatitis B virus; NTCP; Polymorphism