title: Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review.
abstract: Gelatinous marrow transformation (GMT) is a rare condition observed in severe illness or malnutrition, in which the bone marrow contains amorphous "gelatinous" extracellular material, and histopathology demonstrates varied degrees of fat cell atrophy and loss of hematopoietic elements. An association of GMT with imatinib use in chronic myeloid leukemia (CML) has been reported recently. The objective of this study is to describe a case of GMT associated with imatinib use and review the existing similar cases in the literature to identify epidemiological patterns and potential imatinib-induced mechanisms leading to gelatinous conversion.
authors.affiliation: Department of Hematology and Oncology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA; Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
authors.forename: E
authors.identifier: 0000-0001-6255-2853
authors.initials: E
authors.lastname: Chang
authors.affiliation: Department of Hematology and Oncology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA; Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
authors.forename: G
authors.identifier: 0000-0002-2866-9203
authors.initials: G
authors.lastname: Rivero
authors.affiliation: Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Endocrinology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA.
authors.forename: B
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Hematology and Oncology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA; Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
authors.forename: S
authors.initials: S
authors.lastname: Yellapragada
authors.affiliation: Department of Hematology and Oncology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA; Department of Pathology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA.
authors.forename: P
authors.initials: P
authors.lastname: Thiagarajan