title: Predictors of peripheral arterial disease in SLE change with patient's age.
abstract: OBJECTIVE
  To analyse the differential influence of risk factors of peripheral artery disease (PAD) according to age in patients with SLE.
  
  
  METHODS
  216 patients from the Lupus-Cruces cohort were divided in three age groups: ≤34 years, 35-49 years and ≥50 years. A low ankle-brachial index defined PAD. Significant variables were identified by univariant and multivariant analysis in each age group.
  
  
  RESULTS
  Different factors were identified in different age groups: antiphospholipid antibodies/antiphospholipid syndrome and glucocorticoids in patients ≤34 years; in patients 35-49 years old, hypertension was the only statistically significant predictor, although a trend was observed for fibrinogen levels; a trend was observed for hypercholesterolaemia in those ≥50 years.
  
  
  CONCLUSIONS
  Age may modulate the influence of risk factors for PAD in patients with SLE.
authors.affiliation: Autoimmune Diseases Research Unit, Department of Internal Medicine , Biocruces Health Research Institute, Hospital Universitario Cruces, University of The Basque Country , Bizkaia, The Basque Country , Spain.
authors.forename: Jose-Gabriel
authors.initials: JG
authors.lastname: Erdozain
authors.affiliation: Autoimmune Diseases Research Unit, Department of Internal Medicine , Biocruces Health Research Institute, Hospital Universitario Cruces, University of The Basque Country , Bizkaia, The Basque Country , Spain.
authors.forename: Irama
authors.initials: I
authors.lastname: Villar
authors.affiliation: Autoimmune Diseases Research Unit, Department of Internal Medicine , Biocruces Health Research Institute, Hospital Universitario Cruces, University of The Basque Country , Bizkaia, The Basque Country , Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Nieto
authors.affiliation: Autoimmune Diseases Research Unit, Department of Internal Medicine , Biocruces Health Research Institute, Hospital Universitario Cruces, University of The Basque Country , Bizkaia, The Basque Country , Spain.
authors.forename: Ioana
authors.initials: I
authors.lastname: Ruiz-Arruza
authors.affiliation: Autoimmune Diseases Research Unit, Department of Internal Medicine , Biocruces Health Research Institute, Hospital Universitario Cruces, University of The Basque Country , Bizkaia, The Basque Country , Spain.
authors.forename: Guillermo
authors.identifier: 0000-0001-7788-1043
authors.initials: G
authors.lastname: Ruiz-Irastorza
keywords: Antiphospholipid Syndrome; Systemic Lupus Erythematosus; ankle-brachial index; peripheral arterial disease