title: Correlations of serum cystatin C and glomerular filtration rate with vascular lesions and severity in acute coronary syndrome.
abstract: The aim of this study was to evaluate the predictive value of cystatin C (CysC) and estimated glomerular filtration rate (eGFR) regarding vascular lesions and their severity in patients with acute coronary syndrome (ACS).
  
  
  
  According to the results of coronary angiography, 195 ACS patients were divided into a single-vascular-lesion group (91 cases), a dual-vascular-lesion group (67 cases), and a multiple-vascular-lesion group (37 cases) to assess the severity of coronary artery disease according to Gensini scores and to analyze the correlations of CysC and eGFR level with vascular lesions and severity in ACS patients.
  
  
  
  Intergroup comparisons of univariate and multivariate regression analyses showed that CysC was positively correlated with vascular lesions (P < 0.05), but eGFR showed no correlation. Regarding the severity of vascular lesions, CysC was positively correlated with Gensini score (Pearson's correlation coefficient r = 0.1811, P < 0.05), but eGFR was not correlated (P > 0.05).
  
  
  
  Serum CysC levels could reflect the severity of vascular lesions in ACS patients, and a high CysC level had predictive value regarding the severity of vascular lesions in ACS.
authors.affiliation: Department of Cardiology, North Huashan Hospital of Fudan University, Shanghai, 201907, People's Republic of China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Tongren Hospital, Shanghai, 200050, People's Republic of China.
authors.forename: Xianhao
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Beixinjing Community Health Center, Shanghai, 200335, People's Republic of China.
authors.forename: Peizhen
authors.initials: P
authors.lastname: Gao
authors.affiliation: Department of Cardiology, North Huashan Hospital of Fudan University, Shanghai, 201907, People's Republic of China. pingpingyandoc@163.com.
authors.forename: Pingping
authors.initials: P
authors.lastname: Yan
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D023921:Coronary Stenosis / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D055316:Cystatin C / Q000032:analysis*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C
keywords: Acute coronary syndrome; Correlation study; Glomerular filtration rate; Serum cystatin C