title: Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities (Review).
abstract: The study of wound‑healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemicals are involved in the healing process of the body, including antioxidants and cytokines. Although several pharmaceutical preparations and formulations are available for wound care and management, it remains necessary to search for efficacious treatments, as certain current formulations cause adverse effects or lack efficacy. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via various mechanisms. Several herbal medicines have displayed marked activity in the management of wounds and various natural compounds have verified in vivo wound healing potential, and can, therefore, be considered as potential drugs of natural origin. Chromolaena odorata (L.) R.M. King and H. Robinson is considered a tropical weed. However, it exhibits anti‑inflammatory, antipyretic, analgesic, antimicrobial, cytotoxic and numerous other relevant medicinal properties on an appreciable scale, and is known in some parts of the world as a traditional medicine used to treat various ailments. To understand its specific role as nature's gift for healing wounds and its contribution to affordable healthcare, this plant must be scientifically assessed based on the available literature. This review aims to summarize the role of C. odorata and its biomarkers in the wound healing activities of biological systems, which are crucial to its potential future drug design, development and application for the treatment of wounds.
authors.affiliation: School of Life Sciences, B.S. Abdur Rahman University, Chennai, Tamil Nadu 600048, India.
authors.forename: Kavitha
authors.initials: K
authors.lastname: Vijayaraghavan
authors.affiliation: Department of Biotechnology, Rajalakshmi Engineering College, Chennai, Tamil Nadu 602105, India.
authors.forename: Johanna
authors.initials: J
authors.lastname: Rajkumar
authors.affiliation: Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
authors.forename: Syed Nasir Abbas
authors.initials: SN
authors.lastname: Bukhari
authors.affiliation: Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia.
authors.forename: Badr
authors.initials: B
authors.lastname: Al-Sayed
authors.affiliation: Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
authors.forename: Mohammed Ali
authors.initials: MA
authors.lastname: Seyed
mesh_terms: D036604:Chromolaena / Q000737:chemistry; D008519:Medicine, Traditional; D064209:Phytochemicals / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects
chemical_list: D064209:Phytochemicals; D010936:Plant Extracts; D028321:Plant Preparations