title: Intermediate analysis of magnesium alloy covered stent for a lateral aneurysm model in the rabbit common carotid artery.
abstract: OBJECTIVE
  To analyze the outcomes of a magnesium alloy covered stent (MACS) for a lateral aneurysm model in common carotid artery (CCA).
  
  
  METHODS
  In 32 rabbits, a MACS (group A, n = 17) or a Willis covered stent (WCS; group B, n = 15) was inserted and the rabbits were sacrificed 1, 3, 6, or 12 months after stenting. Angiography and intravascular ultrasound (IVUS) were performed at 3, 6, and 12 months. Scanning electron microscopy was performed for six stents in each group at 1, 3, and 6 months, and histopathology and histomorphology were conducted at 3 (n = 4), 6 (n = 4), and 12 (n = 12) months.
  
  
  RESULTS
  Final angiography showed complete occlusion of the aneurysms in 12 cases. IVUS at 6 and 12 months revealed a significant increase in mean lumen area of the stented CCA in group A and also showed greater mean lumen area in group A than in group B. The endothelialization process was quicker in group A than in group B.
  
  
  CONCLUSIONS
  MACS is effective for occlusion of lateral aneurysms and is superior to WCS in growth of the stented CCA and endothelialization. Further work is needed to make this device available for human use.
  
  
  CONCLUSIONS
  • The MACS is an effective approach for occlusion of a lateral aneurysm. • IVUS showed that the CCA could grow following degradation of the MACS. • The lumen area of the stented CCA was excellent in MACS. • HE staining displayed the degradation of the magnesium alloy stent. • Combination of IVUS and DSA were applied in this study.
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.|, No.88, Jian Kang Road, Weihui, 453100, Henan Province, China.
authors.forename: Hong-Kai
authors.initials: HK
authors.lastname: Cui
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.|, No.88, Jian Kang Road, Weihui, 453100, Henan Province, China.
authors.forename: Fen-Bao
authors.initials: FB
authors.lastname: Li
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.|, No.88, Jian Kang Road, Weihui, 453100, Henan Province, China.
authors.forename: Ying-Chang
authors.initials: YC
authors.lastname: Guo
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.|, No.88, Jian Kang Road, Weihui, 453100, Henan Province, China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Zhao
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China.|, No.88, Jian Kang Road, Weihui, 453100, Henan Province, China.
authors.forename: Rui-Fang
authors.initials: RF
authors.lastname: Yan
authors.affiliation: Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, 200233, China.|, No. 600, Yi Shan Road, Shanghai, 200233, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, China. dr_liyongdong@sina.com.|, No.88, Jian Kang Road, Weihui, 453100, Henan Province, China. dr_liyongdong@sina.com.|Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, 200233, China. dr_liyongdong@sina.com.|, No. 600, Yi Shan Road, Shanghai, 200233, China. dr_liyongdong@sina.com.
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Li
authors.affiliation: Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, 200233, China. yongliwang2008@163.com.|, No. 6600, Nan Feng Road, Shanghai, 210499, China. yongliwang2008@163.com.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Wang
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China. gyyuan@sjtu.edu.cn.|, No. 800, Dong Chuan Road, Shanghai, 200240, China. gyyuan@sjtu.edu.cn.
authors.forename: Guang-Yin
authors.initials: GY
authors.lastname: Yuan
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000783:Aneurysm / Q000601:surgery*; D000792:Angiography; D000818:Animals; D002339:Carotid Arteries; D002340:Carotid Artery Diseases / Q000601:surgery*; D017536:Carotid Artery, Common / Q000601:surgery; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D008274:Magnesium; D008297:Male; D011817:Rabbits; D015607:Stents; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000295:instrumentation*
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D008274:Magnesium
keywords: Common carotid artery; Covered stent; Degradation; Intravascular ultrasound (IVUS); Mg alloy stent