title: IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant.
abstract: A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component vaccine STn-αGalCer is devoid of antigenic peptide, featuring the well-defined structure with high simplicity. STn-αGalCer showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes of IgG antibody were primarily IgG1 and IgG3.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Xu-Guang
authors.initials: XG
authors.lastname: Yin
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Xiang-Zhao
authors.initials: XZ
authors.lastname: Chen
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Wen-Mei
authors.initials: WM
authors.lastname: Sun
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Geng
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Xiao-Kang
authors.initials: XK
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University , Wuhan, Hubei 430060, P. R. China.
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Ji
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University , Wuhan, Hubei 430060, P. R. China.
authors.forename: Zhong-Yin
authors.initials: ZY
authors.lastname: Zhou
authors.affiliation: College of Pharmacy, Natural Medicine Research Institute, Mokpo National University , 1666 Youngsan-ro, Muan-gun, Jeonnam 534-729, Korea.
authors.forename: Dong Jae
authors.initials: DJ
authors.lastname: Baek
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Guang-Fu
authors.identifier: 0000-0003-4384-2593
authors.initials: GF
authors.lastname: Yang
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Zheng
authors.identifier: 0000-0002-3696-339X
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo