title: Click and Release: SO2Prodrugs with Tunable Release Rates.
abstract: Employing an intramolecular cycloaddition reaction, we have developed a series of SO2prodrugs with tunable release rates with half-lives ranging from minutes to days.
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.
authors.forename: Xingyue
authors.initials: X
authors.lastname: Ji
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
authors.forename: Eman M
authors.initials: EM
authors.lastname: El-Labbad
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.
authors.forename: Kaili
authors.initials: K
authors.lastname: Ji
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
authors.forename: Deena S
authors.initials: DS
authors.lastname: Lasheen
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
authors.forename: Rabah A T
authors.initials: RA
authors.lastname: Serya
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Abouzid
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.
authors.forename: Binghe
authors.identifier: 0000-0002-2200-5270
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D057930:Click Chemistry; D061565:Cycloaddition Reaction; D015195:Drug Design; D065546:Drug Liberation; D006207:Half-Life; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D051379:Mice; D015394:Molecular Structure; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism*; D000067996:RAW 264.7 Cells; D013329:Structure-Activity Relationship; D013458:Sulfur Dioxide / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011355:Prodrugs; D013458:Sulfur Dioxide