title: Mitochondrial DNA control region sequences may differentiate Yanbian Koreans in China from other Asian populations.
abstract: BACKGROUND
  Sequence polymorphisms of mitochondrial DNA (mtDNA) are valuable in forensic medicine and anthropological genetics.
  
  
  OBJECTIVE
  This study investigated the mtDNA control region sequences in 295 unrelated individuals living in the Yanbian Korean Autonomous Prefecture in the People's Republic of China.
  
  
  METHODS
  DNA was extracted from blood stained filter papers. Hypervariable regions of the mtDNA control region (HVI and HVII) were amplified and sequenced. The resulting sequences were aligned and compared with the revised Cambridge reference sequence (rCRS).
  
  
  RESULTS
  A total of 182 variations were confirmed. Population comparison showed the significant difference between Yanbian Korean and other included populations.
  
  
  CONCLUSIONS
  These results provide useful data for human genetic studies and forensic examinations and demonstrate that the Yanbian Korean population is an endogamous Northeast Asian group.
authors.affiliation: a School of Forensic Medicine , China Medical University , Shenyang , PR China.|b School of Fundamental Sciences , China Medical University , Shenyang , PR China.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Li
authors.affiliation: c Department of Forensic Medicine , China Criminal Police College , Shenyang , PR China.
authors.forename: Ji-Long
authors.initials: JL
authors.lastname: Zheng
authors.affiliation: a School of Forensic Medicine , China Medical University , Shenyang , PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.affiliation: a School of Forensic Medicine , China Medical University , Shenyang , PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Dong
authors.affiliation: a School of Forensic Medicine , China Medical University , Shenyang , PR China.
authors.forename: Zhang-Sen
authors.initials: ZS
authors.lastname: Shi
authors.affiliation: a School of Forensic Medicine , China Medical University , Shenyang , PR China.
authors.forename: Bao-Jie
authors.initials: BJ
authors.lastname: Wang
mesh_terms: D002681:China; D004272:DNA, Mitochondrial / Q000235:genetics*; D056911:Democratic People's Republic of Korea / Q000208:ethnology; D006801:Humans; D019901:Locus Control Region; D011110:Polymorphism, Genetic; D056910:Republic of Korea / Q000208:ethnology; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial
keywords: haplogroup; haplotype; hypervariable region; mtDNA