title: A novel seven-long non-coding RNA signature predicts survival in early stage lung adenocarcinoma.
abstract: Increasing evidence has revealed the significant association between dysregulated lncRNA expression and cancers. The prognostic value of lncRNAs in predicting the risk of disease recurrence and identifying high-risk subgroup of early stage lung adenocarcinoma (LUAD) is still unclear. In this study, we analyzed lncRNA expression profiles of 415 early-stage LUAD patients from Gene Expression Omnibus and identified a novel seven-lncRNA signature that was significantly associated with survival in patients with early-stage LUAD (HR = 2.718, CI = 2.054-3.597, p < 0.001). Based on the seven-lncRNA signature, we constructed a risk score model which is able to classify patients of training dataset into the high-risk group and the low-risk group with significantly different clinical outcome (p < 0.001). The robustness of the seven-lncRNA signature was successfully validated through application in other two independent patient datasets. Furthermore, the prognostic value of seven-lncRNA signature was independent of other clinicopathological factors including age, gender, stage and smoking status. Functional analysis suggested that the seven-lncRNA signature may be involved in a variety of biological pathways including cell cycle, ECM-receptor interaction, Focal adhesion and p53 signaling pathway. Taken together, our study not only provides insights into the lncRNA association with LUAD, but also provide alternative molecular markers in prognosis prediction for early-stage LUAD patients.
authors.affiliation: Department of Anatomy, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Anatomy, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Baoquan
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Anatomy, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Jianbing
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin 150040, PR China.
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Anatomy, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Yafang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D012372:ROC Curve; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: long non-coding RNAs; lung adenocarcinoma; prognosis; survival