title: Spontaneous Remission in an Older Patient with RelapsedFLT3ITD Mutant AML.
abstract: Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized byFLT3internal tandem duplication (FLT3ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR ofFLT3ITD mutant AML in the literature. Our patient was an elderly woman with relapsedNPM1andFLT3ITD mutant AML whose disease underwent SR for a brief duration without precipitating cause. We review the potential immune mechanisms underlying SR in AML and discuss the implications for novel immunotherapeutic approaches forFLT3mutant AML.
authors.affiliation: Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Pankit
authors.identifier: 0000-0001-9779-6217
authors.initials: P
authors.lastname: Vachhani
authors.affiliation: Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Jason H
authors.initials: JH
authors.lastname: Mendler
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Evans
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
authors.forename: George
authors.initials: G
authors.lastname: Deeb
authors.affiliation: Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Petr
authors.initials: P
authors.lastname: Starostik
authors.affiliation: Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Wallace
authors.affiliation: Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Eunice S
authors.initials: ES
authors.lastname: Wang