title: Two dimensional magnetic particle spectrometry.
abstract: Magnetic particle spectrometry (MPS) is an excellent and straight forward method to determine the response of magnetic nanoparticles to an oscillating magnetic field. Such fields are applied in magnetic particle imaging (MPI). However, state of the art MPS devices lack the ability to excite particles in multidimensional field sequences that are present in MPI devices. Especially the particle behavior caused by Lissajous sequences cannot be measured with only one excitation direction. This work presents a new kind of MPS which features two excitation directions to overcome this limitation. Both field coils can drive AC as well as DC currents and are thereby able to emulate the field sequences for arbitrary spatial positions inside an MPI device. Since the DC currents can be switched very fast, the device can be used as system calibration unit and acquire system matrices in very short time. These are crucial for MPI image reconstruction. As the signal-to-noise-ratio provided by the MPS is approximately 1000 times higher than that of actual imaging devices, the time space analysis of particle signals is more precise and easier done. Four system matrices are presented in this paper which have been measured with the realized multidimensional MPS. Additionally, a time space comparison of the particle signal for Lissajous, radial and spiral trajectories is given.
authors.affiliation: Institute of Medical Engineering, Universität zu Lübeck, Ratzeburger Allee 160, Lübeck, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Graeser
authors.forename: A
authors.initials: A
authors.lastname: von Gladiss
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.forename: T M
authors.initials: TM
authors.lastname: Buzug
mesh_terms: D000465:Algorithms; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008280:Magnetics; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles; D059629:Signal-To-Noise Ratio