title: Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies.
abstract: To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for-gestational-age (LGA) and small-for-gestational-age (SGA) cases in a nested case-control study. Maternal serum samples were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Serum hormone concentrations were determined by ELISA. We found that maternal serum GH-V concentrations at 20 weeks of gestation in LGA pregnancies were significantly higher than in AGA and SGA pregnancies. Maternal GH-V concentrations were positively correlated to birth weights and customized birth weight centiles, while IGFBP-1 concentrations were inversely related to birth weights and customized birth weight centiles. Our findings suggest that maternal serum GH-V and IGFBP-1 concentrations at 20 weeks' gestation are associated with fetal growth.
authors.affiliation: a Liggins Institute, University of Auckland , Auckland , New Zealand.|b Gravida: National Centre for Growth and Development , Auckland , New Zealand.|c The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
authors.forename: Shutan
authors.initials: S
authors.lastname: Liao
authors.affiliation: a Liggins Institute, University of Auckland , Auckland , New Zealand.|b Gravida: National Centre for Growth and Development , Auckland , New Zealand.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Vickers
authors.affiliation: d Department of Obstetrics and Gynaecology , University of Auckland , Auckland , New Zealand.
authors.forename: Rennae S
authors.initials: RS
authors.lastname: Taylor
authors.affiliation: e Institute of Natural and Mathematical Sciences, Massey University , Auckland , New Zealand.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Jones
authors.affiliation: f Department of Physiology , University of Auckland , Auckland , New Zealand , and.
authors.forename: Mhoyra
authors.initials: M
authors.lastname: Fraser
authors.affiliation: d Department of Obstetrics and Gynaecology , University of Auckland , Auckland , New Zealand.
authors.forename: Lesley M E
authors.initials: LM
authors.lastname: McCowan
authors.affiliation: a Liggins Institute, University of Auckland , Auckland , New Zealand.|b Gravida: National Centre for Growth and Development , Auckland , New Zealand.|g College of Medicine, Biological Sciences and Psychology, University of Leicester , Leicester , UK.
authors.forename: Philip N
authors.initials: PN
authors.lastname: Baker
authors.affiliation: a Liggins Institute, University of Auckland , Auckland , New Zealand.|b Gravida: National Centre for Growth and Development , Auckland , New Zealand.
authors.forename: Jo K
authors.initials: JK
authors.lastname: Perry
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D047109:Fetal Development; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D010926:Placental Hormones / Q000097:blood*; D011247:Pregnancy
chemical_list: C064980:GH2 protein, human; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D010926:Placental Hormones; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: Placental growth hormone; birth weight; large-for-gestational-age; pregnancy