title: [Lymph Node Recurrence of Small Cell Carcinoma of the Extrahepatic Bile Ducts Effectively Treated with Cisplatin plus Irinotecan Chemotherapy - Report of a Case].
abstract: A 78-year-old man with jaundice was diagnosed with perihilar cholangiocarcinoma(Bismuth type I ). After endoscopic biliary drainage for jaundice, a subtotal stomach-preserving pancreaticoduodenectomy was performed. Histologic examination and immunohistochemical staining with chromogranin A, synaptophysin, and CD56 resulted in a diagnosis of small cell carcinoma. Of the 18 dissected lymph nodes, 8 nodes contained a metastatic tumor. Left supraclavicular and paraaortic lymph node metastases were detected by computed tomography 5 months after the resection. He received cisplatin plus irinotecan chemotherapy, and after 2 courses of the chemotherapy, both metastatic lesions were reduced in size. He remains alive and well with no evidence of progressive disease after 6 courses of chemotherapy.
authors.affiliation: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katada
authors.forename: Jun
authors.initials: J
authors.lastname: Sakata
authors.forename: Takuya
authors.initials: T
authors.lastname: Ando
authors.forename: Daiki
authors.initials: D
authors.lastname: Soma
authors.forename: Kizuki
authors.initials: K
authors.lastname: Yuza
authors.forename: Koji
authors.initials: K
authors.lastname: Toge
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hirosuke
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Kohei
authors.initials: K
authors.lastname: Miura
authors.forename: Taku
authors.initials: T
authors.lastname: Ohashi
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Takizawa
authors.forename: Kabuto
authors.initials: K
authors.lastname: Takano
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kameyama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Wakai
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017734:Bile Ducts, Extrahepatic / Q000473:pathology* / Q000601:surgery; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin