title: [A Case of Neuroendocrine Carcinoma of the Esophagus Treated with Neoadjuvant Chemotherapy Comprising 5-Fluorouracil plus Cisplatin].
abstract: Esophageal neuroendocrine carcinoma is relatively rare and the prognosis is poor owing to its aggressive malignancy. We experienced a case of neuroendocrine carcinoma of the esophagus treated with neoadjuvant chemotherapy of 5-fluorouracil plus cisplatin. A 71-year-old man was diagnosed with esophageal carcinoma(clinical T3N1M0, Stage III ). He received neoadjuvant chemotherapy comprising 5-fluorouracil plus cisplatin, followed by subtotal esophagectomy with dissection of 3 regional lymph nodes. Immunohistochemical findings were synaptophysin-positive, CD56-positive, Ki-67(labeling index) B90%. The final diagnosis was neuroendocrine carcinoma, categorized as CT-pT1a-MM, pN0, Stage 0. The pathological response to neoadjuvant chemotherapy was Grade 2. The patient is alive 8 months after esophagectomy without metastasis.
authors.affiliation: Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Muroya
authors.forename: Naoki
authors.initials: N
authors.lastname: Wajima
authors.forename: Harue
authors.initials: H
authors.lastname: Akasaka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hasebe
authors.forename: Yuta
authors.initials: Y
authors.lastname: Yakoshi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yachi
authors.forename: Takanobu
authors.initials: T
authors.lastname: Akaishi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Sato
authors.forename: Yuto
authors.initials: Y
authors.lastname: Mitsuhashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016629:Esophagectomy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy
chemical_list: D002945:Cisplatin; D005472:Fluorouracil