title: Influence of Prescribed Blood Products on the Incidence of Deep Vein Thrombosis and Pulmonary Embolism in Surgical Patients.
abstract: Deep vein thrombosis (DVT) and pulmonary embolisms (PEs) are common complications after surgical procedures. The influence of prescribed blood products on the occurrence of DVT and PE was evaluated in postsurgical patients in this retrospective case-control study. The records of 286 surgical patients were analyzed: DVT (n = 52), PE (n = 92), and a control group (n = 142). The amounts of prescribed blood, blood products, and vitamin K were reviewed, together with appropriate prescribing of low-molecular-weight heparins. The influence of prescribed blood products on the occurrence of DVT or PE was analyzed using multinomial logistic regression. We demonstrated a significant difference between the test and control groups ( P < .05) in relation to receiving packed red blood cells. Treatment with red blood cells was associated with an increased risk of PE but not DVT. Patients who developed PE after surgery were hospitalized for longer (median 10 days) than patients with DVT (median 6 days). There was no difference between the test and control groups concerning treatment with fresh frozen plasma. Inadequate thromboprophylaxis significantly increased the likelihood of DVT. There is a connection between receiving packed red blood cells and occurrence of postoperative PE in surgical patients. Thus, patients receiving red blood cells should be monitored more closely after surgery, as they are more likely to develop PE postoperatively.
authors.affiliation: 1 Hospital Pharmacy, General Hospital Murska Sobota, Murska Sobota, Slovenia.|2 Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Alenka Premuš
authors.initials: AP
authors.lastname: Marušič
authors.affiliation: 2 Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Igor
authors.initials: I
authors.lastname: Locatelli
authors.affiliation: 2 Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Aleš
authors.initials: A
authors.lastname: Mrhar
authors.affiliation: 3 2nd Department of Internal Medicine, Comenius University and University Hospital, Bratislava, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Caprnda
authors.affiliation: 3 2nd Department of Internal Medicine, Comenius University and University Hospital, Bratislava, Slovakia.
authors.forename: Ludovit
authors.initials: L
authors.lastname: Gaspar
authors.affiliation: 4 Department of Thoracic Surgery, Medical University of Silesia, Katowice, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Adamek
authors.affiliation: 5 Department of Chemical Drugs, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.|6 2nd Department of Surgery, Masaryk University, Brno, Czech Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.affiliation: 7 Faculty of Medicine, Institute of Histology and Embryology, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrovič
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017707:Erythrocyte Transfusion; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011183:Postoperative Complications / Q000453:epidemiology / Q000628:therapy*; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D014812:Vitamin K / Q000008:administration & dosage*
chemical_list: D006495:Heparin, Low-Molecular-Weight; D014812:Vitamin K
keywords: blood replacement; prevention of venous thromboembolism; red blood cells; vitamin K