title: Detection ofHelicobacter pyloriin the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR.
abstract: BACKGROUND
  Lung cancer is one of the most common causes of death worldwide. Although smoking and environmental pollutants are the most important risk factors of lung cancer, the role of infectious causes should also be considered in the pathogenesis and progress of lung cancer.
  
  
  OBJECTIVE
  This study examined the relationship betweenHelicobacter pyloriand lung cancer through serology, real-time PCR, and urease tests.
  
  
  METHODS
  This descriptive cross-sectional study was conducted on 52 adult patients with lung cancer who were selected after having their history taken and being physically examined by a pulmonologist. Then, the patients underwent a bronchoscopy, a BAL, and biopsy sampling. A urease test was run for each biopsy sample, real-time PCR was used for each BAL sample, andH. pyloriserology was used for each patient's serum.
  
  
  RESULTS
  The patients' average age was 60.65 ± 9.15 years; 11.5% were female and 88.5% were male. The prevalence ofH. pyloriin lung cancer patients was 11.5% according to the BAL PCR test, 92.3% according to the serology test, and 3.8% according to the urease test.
  
  
  CONCLUSIONS
  The results demonstrated an association between of lung cancer andH. Pyloriinfection via the hypothesis of direct damage and chronic inflammation through inhalation and aspiration and the systematic immune response induced byH. pyloricolonization.Helicobacter pylori, together with a host's genetic predisposition and other environmental risk factors, could be attributed to the induction of lung cancer.
authors.affiliation: Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IR Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Samareh-Fekri
authors.affiliation: Afzalipour Hospital Research Center, Kerman University of Medical Sciences,Kerman, IR Iran.
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Hashemi Bajgani
authors.affiliation: Afzalipour Hospital Research Center, Kerman University of Medical Sciences,Kerman, IR Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shafahi
authors.affiliation: Afzalipour Hospital Research Center, Kerman University of Medical Sciences,Kerman, IR Iran.
authors.forename: Mahbobeh
authors.initials: M
authors.lastname: Asadi-Zarandi
authors.affiliation: Afzalipour Hospital Research Center, Kerman University of Medical Sciences,Kerman, IR Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Mollaie
authors.affiliation: Afzalipour Hospital Research Center, Kerman University of Medical Sciences,Kerman, IR Iran.
authors.forename: Arshia
authors.initials: A
authors.lastname: Jamali Paghalhe
keywords: Helicobacter pylori; Pulmonary Neoplasm; Real-Time PCR