title: Hypoxia and antitumor CD8+T cells: An incompatible alliance?
abstract: T Lymphocytes face pathologically low O2tensions within the tumor bed at which they will have to function in order to impact on the malignancy. Recent studies highlighting the importance of O2and hypoxia-inducible factors for CD8+T-cell function and fate must now be integrated into tumor immunology concepts if immunotherapies are to progress. Here, we discuss, reinterpret, and reconcile the many apparent contradictions in these data and we propose that O2is a master regulator of the CD8+T-cell response. Certain T cell functions are enhanced, others suppressed, but on balance, hypoxia is globally detrimental to the antitumor response.
authors.affiliation: Geneva University Hospitals and University of Geneva, Geneva, Switzerland; Ludwig Center for Cancer Research of the University of Lausanne, Biopôle III, Epalinges, Switzerland.
authors.forename: Romain
authors.initials: R
authors.lastname: Vuillefroy de Silly
authors.affiliation: Geneva University Hospitals and University of Geneva , Geneva, Switzerland.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Dietrich
authors.affiliation: Geneva University Hospitals and University of Geneva , Geneva, Switzerland.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Walker
keywords: CD8+ T cell; CTL; Cancer; hypoxia; normoxia; oxygen; physioxia; tumor