title: [Microtubule severing proteins - structure and activity regulation].
abstract: Microtubule severing proteins, katanin, spastin and fidgetin cause local destabilization of the microtubules structure. This ATP-dependent activity leads to the shortening or disassembly of the existing microtubules. The generated short microtubule fragments may serve as templates to polymerize new microtubules and in consequence, the activity of the microtubule severing proteins leads to the reorganization of the microtubular cytoskeleton. This review summarizes current knowledge concerning structural organization of the microtubule severing proteins, the molecular mechanism of their action, factors that regulate the level of the katanin and spastin within the cells and their microtubule severing activity.
authors.affiliation: Laboratory of Cytoskeleton and Cilia Biology, Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw; 3 Pasteur St., 02-093 Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wacławek
authors.affiliation: Laboratory of Cytoskeleton and Cilia Biology, Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw; 3 Pasteur St., 02-093 Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Włoga
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities / Q000737:chemistry / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006801:Humans; D000074201:Katanin / Q000737:chemistry / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D011487:Protein Conformation; D000074181:Spastin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008869:Microtubule-Associated Proteins; D000255:Adenosine Triphosphate; D000074183:ATPases Associated with Diverse Cellular Activities; C000613810:FIGN protein, human; D000074181:Spastin; C000600349:KATNAL1 protein, human; D000074201:Katanin; C400283:SPAST protein, human
keywords: fidgetin; katanin; microtubule severing proteins; microtubules; spastin