title: Ratio of matrix metalloproteinase-2 to -9 is a more accurate predictive biomarker in women with suspected pre-eclampsia.
abstract: Pre-eclampsia (PE) is a condition unique to pregnancy, and abnormal expression of matrix metalloproteinases (MMPs) has been implicated in its pathogenesis. We aimed to evaluate the reliability of plasma levels of MMP-2, MMP-9 and their relative ratio in predicting PE. A total of 318 women with suspected PE were recruited for the study, who were subsequently either cleared or diagnosed of PE and grouped accordingly. Their baseline characteristics were compared. Blood samples were also collected from all participants, to determine the plasma levels of MMP-2 and MMP-9. The predictive values of levels of MMP-2 and MMP-9, as well as their ratio, were analyzed using the receiver operating characteristic (ROC) curve. Either MMP-2 or MMP-9 alone did not exhibit any obvious differences between normal and PE pregnancies. However the ratio of MMP-2/MMP-9 was significantly higher in PE-affected pregnancy than normal control group. ROC curve analysis also indicated that the MMP-2/MMP-9 ratio provided better compromise between specificity and sensitivity in distinguishing PE from normal pregnancies, than either of the two MMPs alone. MMP-2/MMP-9 ratio is a more accurate biomarker to predict PE than either MMP-2 or MMP-9 alone.
authors.affiliation: Department of Obstetrics and Gynecology, Shandong Provincial Qianfoshan Hospital affiliated to Shandong University, Jinan 250014, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Feng
authors.affiliation: Department of Obstetrics and Gynecology, Shandong Provincial Qianfoshan Hospital affiliated to Shandong University, Jinan 250014, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Shandong Provincial Qianfoshan Hospital affiliated to Shandong University, Jinan 250014, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Shandong Provincial Qianfoshan Hospital affiliated to Shandong University, Jinan 250014, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Shandong Provincial Qianfoshan Hospital affiliated to Shandong University, Jinan 250014, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Department of Obstetrics and Gynecology, Provincial Hospital affiliated to Shandong University, Key Laboratory of Birth Regulation and Control Technology of National Health and Family Planning Commission of China, Maternal and Child Health Care of Shandong Province, Jinan 250014, China xietongwangg@sina.com.
authors.forename: Xietong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: matrix metalloproteinase; predictive biomarker; preeclampsia; pregnancy; receiver operating characte