title: Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients.
abstract: Objective. The objective of the study was to assess the serum vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) and find association between serum VEGF levels and PIH.Methods. Thirty-five PIH subjects, 35 normal pregnant females, and 20 normal healthy females were included in the study. Detailed history, clinical examination, and relevant biochemical parameters were assessed; serum VEGF levels were estimated using Double-antibody enzyme-linked immunosorbent assay.Results. The study groups were found to be age matched (p= 0.38). VEGF level in the pregnancy-induced hypertensive group (median = 109.19 (3.38 ± 619)) was significantly higher than the normal pregnant (median = 20.82 (1.7-619)) and control (median = 4.92 (1.13-13.07)) group and the difference between these three groups was significant (p< 0.0001). The 3 groups are found to be significantly different in terms of RBS (p= 0.01), urea (p< 0.0001), creatinine (p= 0.0005), AST (p= 0.0032), ALT (p= 0.0007), total protein (p= 0.0004), albumin (p< 0.0001), calcium (p= 0.001), and sodium (p= 0.02), while no statistically significant difference was found between total bilirubin (p= 0.167), direct bilirubin (p= 0.07), uric acid (p= 0.16), and potassium (p= 0.14).Conclusion. Significantly higher levels of serum VEGF were noted in PIH subjects compared to normal pregnant and control subjects.
authors.affiliation: Department of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India.
authors.forename: Vibha
authors.initials: V
authors.lastname: Tandon
authors.affiliation: Department of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Hiwale
authors.affiliation: Department of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India.
authors.forename: Dnyanesh
authors.initials: D
authors.lastname: Amle
authors.affiliation: Department of Obstetrics and Gynaecology, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India.
authors.forename: Tripti
authors.initials: T
authors.lastname: Nagaria
authors.affiliation: Department of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India.
authors.forename: Pradeep Kumar
authors.identifier: 0000-0003-4426-0384
authors.initials: PK
authors.lastname: Patra
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia; D011247:Pregnancy; D012372:ROC Curve; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
chemical_list: D042461:Vascular Endothelial Growth Factor A