title: Molecular and cellular insights into Zika virus-related neuropathies.
abstract: Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and Guillain-Barré syndrome (GBS) in the adult. In this review, we focus on the underlying cellular and molecular mechanisms by which vertically transmitted microorganisms reach the fetus and trigger neuropathies.
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 21008, China.|Department of Infectious Disease, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 21008, China.
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 21008, China.
authors.forename: Di
authors.initials: D
authors.lastname: Yu
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 21008, China.
authors.forename: Hesuyuan
authors.initials: H
authors.lastname: Huang
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210008, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 21008, China. xuming_mo@126.com.
authors.forename: Xuming
authors.initials: X
authors.lastname: Mo
mesh_terms: D000330:Aedes / Q000821:virology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005333:Fetus; D020275:Guillain-Barre Syndrome / Q000235:genetics / Q000473:pathology / Q000821:virology*; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007303:Insect Vectors / Q000821:virology*; D051379:Mice; D008831:Microcephaly / Q000235:genetics / Q000473:pathology / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000235:genetics / Q000473:pathology / Q000821:virology*; D000071244:Zika Virus / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D000071243:Zika Virus Infection / Q000235:genetics / Q000473:pathology / Q000635:transmission / Q000821:virology*
keywords: Guillain–Barré syndrome; Microcephaly; Neurodevelopment; Zika virus