title: Feasibility of long-term continuous subcutaneous magnesium supplementation in a patient with irreversible magnesium wasting due to cisplatin.
abstract: A 39-year-old woman presented with severe, uncontrolled and irreversible hypomagnesaemia, following cisplatin treatment in her childhood. Because high-dose oral magnesium supplementation therapy was insufficient and not tolerated, continuous subcutaneous magnesium supplementation was successfully instituted and continued in the outpatient setting. This case demonstrates that continuous subcutaneous magnesium supplementation is effective in maintaining magnesium levels within the normal range, is well tolerated and may provide a long-term solution for chronic hypomagnesaemia due to intractable renal losses.
authors.affiliation: Department of Nephrology, VU University Medical Center Amsterdam, Amsterdam, the Netherlands.
authors.forename: E A
authors.initials: EA
authors.lastname: Vermeulen
authors.forename: M G
authors.initials: MG
authors.lastname: Vervloet
authors.forename: C H
authors.initials: CH
authors.lastname: Lubach
authors.forename: S A
authors.initials: SA
authors.lastname: Nurmohamed
authors.forename: E L
authors.initials: EL
authors.lastname: Penne
mesh_terms: D000328:Adult; D002945:Cisplatin / Q000009:adverse effects*; D019587:Dietary Supplements; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D055104:Infusions, Subcutaneous; D008274:Magnesium / Q000008:administration & dosage*; D015499:Renal Tubular Transport, Inborn Errors / Q000139:chemically induced / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008274:Magnesium; D002945:Cisplatin