title: A European myocardial123I-mIBG cross-calibration phantom study.
abstract: Planar myocardial123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy is a highly reproducible technique. However, differences in collimator use are one of the most important factors that cause variation among institutions and studies in heart-to-mediastinum (H/M) ratio. Therefore, standardization among various gamma camera-collimator combinations is needed. Previously, a phantom has been developed to cross-calibrate different acquisition conditions in Japan. For further cross-calibration of European myocardial123I-mIBG imaging, the aim of this study was to collect123I-mIBG data for H/M ratios from common European gamma camera vendors.
  
  
  
  210 experiments were performed in 27 European institutions. Based on these experiments, conversion coefficients for each gamma camera-collimator combination were calculated. An averaged conversion coefficient of 0.88 was used to calculate a standardized H/M ratio.
  
  
  
  On average, LE-collimator-derived H/M ratios were significantly lower compared to ME-collimator-derived H/M ratios. The mean conversion coefficients ranged from 0.553 to 0.605 for the LE-collimator group and from 0.824 to 0.895 for the ME-collimator group.
  
  
  
  Clinically established H/M ratios can be converted into standardized H/M ratios using cross-calibrated conversion coefficients. This standardization is important for identifying appropriate thresholds for adequate risk stratification. In addition, this cross-calibration enables comparison between different national and international data.
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands. d.o.verschure@amc.uva.nl.|Department of Cardiology, Zaans Medical Center, Zaandam, The Netherlands. d.o.verschure@amc.uva.nl.
authors.forename: Derk O
authors.initials: DO
authors.lastname: Verschure
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
authors.forename: Edwin
authors.initials: E
authors.lastname: Poel
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Physics, Kanazawa Medical University, Uchinada, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Okuda
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
authors.forename: Berthe L F
authors.initials: BLF
authors.lastname: van Eck-Smit
authors.affiliation: Cardiology Centers of the Netherlands, Amsterdam, The Netherlands.
authors.forename: G Aernout
authors.initials: GA
authors.lastname: Somsen
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Verberne
mesh_terms: D019797:3-Iodobenzylguanidine; D002138:Calibration; D015902:Gamma Cameras; D006801:Humans; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals; D012016:Reference Values
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
keywords: 123I-mIBG scintigraphy; calibration phantom; collimator; heart-to-mediastinum ratio; standardization