title: Bartha-k61 vaccine protects growing pigs against challenge with an emerging variant pseudorabies virus.
abstract: Since late 2011, pseudorabies (PR) has resurfaced in many large pig farms, causing great economic loss for the swine industry in China. The PRV variant strain with high virulence and antigenic variation has been considered to be the main cause, and much attention has been focused on how to prevent and control the reoccurrence of this disease in China. In this study, two kinds of vaccination strategy were employed to evaluate the protective effects of Bartha-k61vaccine against both variant PRV (XJ5) and classical PRV (Ra) strain challenge. Humoral immunity response, clinical signs, survival rate, body weight, virus shedding and pathology were assessed in commercial pigs. The results showed that Bartha-k61vaccine, administered either once or twice, was effective against the PRV variant (XJ5) challenge, while no significant differences were observed between single and prime-boost vaccinated pigs. However, pigs vaccinated twice had better body weight gains than those vaccinated once, following challenge with the classical PRV strain (Ra) (p<0.01). Therefore, the Bartha-k61 vaccine appears to be an effective vaccine to control the spread of PRV variants in China in the absence of new powerful candidate vaccines specific to these PRV strains.
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR China.
authors.forename: Jinzhu
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Zou
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR China. Electronic address: gsong@yzu.edu.cn.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000940:Antigenic Variation; D001835:Body Weight / Q000187:drug effects; D002522:Chlorocebus aethiops; D011558:Herpesvirus 1, Suid / Q000187:drug effects* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D056724:Immunity, Humoral / Q000187:drug effects*; D007117:Immunization, Secondary; D000071497:Immunogenicity, Vaccine; D011557:Pseudorabies / Q000276:immunology / Q000401:mortality / Q000517:prevention & control* / Q000821:virology; D022421:Pseudorabies Vaccines / Q000008:administration & dosage*; D016019:Survival Analysis; D013552:Swine; D014611:Vaccination; D014709:Vero Cells; D019562:Viral Load / Q000187:drug effects; D014774:Virulence; D017201:Virus Shedding / Q000187:drug effects
chemical_list: D000914:Antibodies, Viral; D022421:Pseudorabies Vaccines
keywords: Bartha-k61 vaccine; Pseudorabies; Pseudorabies virus; Variant