title: Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528.
abstract: A new griseofulvin derivative, 4'-demethoxy-4'-N-isopentylisogriseofulvin (1), three new indole alkaloids, 2-demethylcyclopiamide E (2), 2-demethylsperadine F (3), and clopiamine C (4), and five known metabolites (5-9) were isolated from Penicillium griseofulvum CPCC 400528. Compound 1 is the first reported griseofulvin analogue with an N-isopentane group and the first example of a naturally occurring N-containing griseofulvin analogue. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu Kα). The possible biogenetic pathway of 1-3 was proposed. Compounds 1, 2, and 5 exhibited anti-HIV activities with IC50values of 33.2, 20.5, and 12.6 μM, respectively.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Dewu
authors.identifier: 0000-0001-6289-0617
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.|College of Herbal Medicine, Tianjin University of Traditional Chinese Medicines , 88 Yuquan Road, Tianjin 300193, People's Republic of China.
authors.forename: Lining
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Fang
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Liu
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Xuefu
authors.initials: X
authors.lastname: You
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Shan
authors.initials: S
authors.lastname: Cen
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Yu
mesh_terms: D002681:China; D018360:Crystallography, X-Ray; D006118:Griseofulvin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*
chemical_list: C000621201:4'-demethoxy-4'-N-isopentylisogriseofulvin; D026121:Indole Alkaloids; D006118:Griseofulvin