title: Computational imaging reveals shape differences between normal and malignant prostates on MRI.
abstract: We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6-9, Stage: T1-T3). The negative group (PCa-) combined 24 biopsy negative (Bx-) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl-). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx- and Cl- prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p < 0.05). The atlas comparison revealed central gland hypertrophy in the Bx- subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Mirabela
authors.initials: M
authors.lastname: Rusu
authors.affiliation: Section of Abdominal Imaging and Nuclear Radiology Department, Imaging Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195, USA.
authors.forename: Andrei S
authors.initials: AS
authors.lastname: Purysko
authors.affiliation: University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, Ohio, 45267, USA.
authors.forename: Sadhna
authors.initials: S
authors.lastname: Verma
authors.affiliation: University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kiechle
authors.affiliation: University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, Ohio, 45267, USA.
authors.forename: Jay
authors.initials: J
authors.lastname: Gollamudi
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Soumya
authors.initials: S
authors.lastname: Ghose
authors.affiliation: University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Karin
authors.initials: K
authors.lastname: Herrmann
authors.affiliation: University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Gulani
authors.affiliation: University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Raj
authors.initials: R
authors.lastname: Paspulati
authors.affiliation: University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Lee
authors.initials: L
authors.lastname: Ponsky
authors.affiliation: Garvan Institute of Medical Research, The Kinghorn Cancer Centre, 384 Victoria St, Darlinghurst, New South Wales, 2010, Australia.
authors.forename: Maret
authors.initials: M
authors.lastname: Böhm
authors.affiliation: Garvan Institute of Medical Research, The Kinghorn Cancer Centre, 384 Victoria St, Darlinghurst, New South Wales, 2010, Australia.
authors.forename: Anne-Maree
authors.initials: AM
authors.lastname: Haynes
authors.affiliation: Radiology Department, Spectrum Medical Imaging, 13-15 Silver St, Randwick, New South Wales, 2031, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Moses
authors.affiliation: Southern Radiology, Neuroscience Research Australia, Barker St &Easy St, Randwick, New South Wales, 2031, Australia.
authors.forename: Ron
authors.initials: R
authors.lastname: Shnier
authors.affiliation: Douglass Hanly Moir Pathology, 14 Giffnock Ave, Macquarie Park, New South Wales, 2113, Australia.
authors.forename: Warick
authors.initials: W
authors.lastname: Delprado
authors.affiliation: Garvan Institute of Medical Research, The Kinghorn Cancer Centre, 384 Victoria St, Darlinghurst, New South Wales, 2010, Australia.|St. Vincent's Prostate Cancer Center, 390 Victoria St, Darlinghurst, New South Wales, 2010, Australia.|School of Medicine, University of New South Wales, 18 High St, Kensington, New South Wales, 2052, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Thompson
authors.affiliation: St. Vincent's Prostate Cancer Center, 390 Victoria St, Darlinghurst, New South Wales, 2010, Australia.
authors.forename: Phillip
authors.initials: P
authors.lastname: Stricker
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, 44106, USA.
authors.forename: Anant
authors.initials: A
authors.lastname: Madabhushi
mesh_terms: D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*