title: Congenital Mesoblastic Nephroma Presenting With Refractory Hypertension in a Premature Neonate: A Case Study.
abstract: The most common nonencapsulated solid renal tumor in the neonatal period is congenital mesoblastic nephroma. Mesoblastic nephroma is a solid lesion originating within or extending from the renal parenchyma. These tumors proliferate rapidly, typically within 3-6 months after birth. Mesoblastic nephromas are stratified by classification as either classical (benign) or atypical (malignant); masses composed of both benign and malignant cells are also reported. The hallmark clinical manifestation of mesoblastic nephroma is a palpable abdominal mass, which may be accompanied by hypertension, hypercalcemia, hematuria, and polyuria. Differentiating between benign and malignant renal tumors is essential to invoke a timely, evidence-based management and treatment plan. With appropriate surgical intervention in a timely manner, prognosis is excellent and mesoblastic nephroma is considered curable. We present a case involving a premature infant with congenital mesoblastic nephroma with discussion of embryology, pathophysiology, diagnostic, management, and prognostic implications for the neonate and family.
authors.forename: Tracey
authors.initials: T
authors.lastname: Robertson-Bell
authors.forename: Desi M
authors.initials: DM
authors.lastname: Newberry
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Jnah
authors.forename: Stephen D
authors.initials: SD
authors.lastname: DeMeo
mesh_terms: D019468:Disease Management; D004351:Drug Resistance; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000628:therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008297:Male; D018201:Nephroma, Mesoblastic / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D010347:Patient Care Planning; D011379:Prognosis; D016896:Treatment Outcome