title: Efficacy and Safety of Oral Spray Containing Lysozyme and Cetylpyridinium: Subjective Determination of Patients with Tonsillopharyngitis.
abstract: BACKGROUND
  Tonsillopharyngitis (sore throat) is a common disease mainly related to the seasonal common cold. To relieve unpleasant symptoms and discomfort of acute tonsillopharyngitis associated with common cold, patients usually take some non-prescription drugs.
  
  
  OBJECTIVE
  The primary aim of this study was to assess subjective determinations of the efficacy and the safety/tolerability of an oral spray comprising a combination of lysozyme chloride and cetylpyridinium chloride in those patients.
  
  
  METHODS
  The study involved 1727 patients with tonsillopharyngitis associated with common cold and treated with the studied drug, in the period from December 2014 through March 2015.
  
  
  RESULTS
  In total, 95% of patients rated the studied drug to be well, very well and excellently effective. In 32% of patients, the symptoms were relieved 10 minutes after the application of the spray. Significant correlations were found between the two subjective assessments of the drug efficiency with the total of 74.11% (95% CI: 73.41, 77.47%) of patients who said that the feeling of pain in the throat completely disappeared after the drug administration, evaluated the impact/effect of the drug was very good or good (Pearson Chi Square=391.401, p<0.001). The effectiveness was significantly better in patients with up to two episodes of common cold a year (Pearson Chi Square=6.101; p=0.014). The studied drug was rated to be well, very well and excellently tolerated by 97% of patients.
  
  
  CONCLUSIONS
  According to patients' subjective assessment, the combination of lysozyme chloride and cetylpyridinium chloride in a formulation of spray can quickly, efficiently and safely resolve the symptoms of acute tonsillopharyngitis associated with common cold.
authors.affiliation: Pharmaceutical Society of Federation of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.
authors.forename: Tarik
authors.initials: T
authors.lastname: Catic
authors.affiliation: Bosnalijek JSC, Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Meliha
authors.initials: M
authors.lastname: Mehic
authors.affiliation: Pharmaceutical Chamber of Federation of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.
authors.forename: Zahida
authors.initials: Z
authors.lastname: Binakaj
authors.affiliation: Public Institution "Sarajevo Pharmacies", Sarajevo, Bosnia and Herzegovina.
authors.forename: Bilsena
authors.initials: B
authors.lastname: Sahman
authors.affiliation: Psychiatric hospital of Canton Sarajevo - Clinical Pharmacy, Sarajevo, Bosnia and Herzegovina.
authors.forename: Vedina
authors.initials: V
authors.lastname: Cordalija
authors.affiliation: Private pharmacy chain "Al Hana" Sarajevo, Bosnia and Herzegovina.
authors.forename: Amra
authors.initials: A
authors.lastname: Kerla
authors.affiliation: Bosnalijek JSC, Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Igor
authors.initials: I
authors.lastname: Martinovic
authors.affiliation: Public Institution "Sarajevo Pharmacies", Sarajevo, Bosnia and Herzegovina.
authors.forename: Hajra
authors.initials: H
authors.lastname: Eskic
keywords: cetylpyridinium; efficacy; lysozyme; oral spray; safety/tolerability; tonsillopharyngitis