title: Major publications in the critical care pharmacotherapy literature in 2015.
abstract: Recently published practice guidelines and research reports on pharmacotherapy in critical care patient populations are summarized.
  
  
  
  The Critical Care Pharmacotherapy Literature Update (CCPLU) Group is composed of over 50 experienced critical care pharmacists who evaluate 31 peer-reviewed journals monthly to identify literature pertaining to pharmacotherapy in critical care populations. Articles are chosen for summarization in a monthly CCPLU Group publication on the basis of applicability and relevance to clinical practice and strength of study design. From January to December 2015, a total of 121 articles were summarized; of these, 3 articles presenting clinical practice guidelines and 12 articles presenting original research findings were objectively selected for inclusion in this review based on their potential to change or reinforce current evidence-based practice. The reviewed guidelines address the management of intracranial hemorrhage (ICH), adult advanced cardiac life support (ACLS) and post-cardiac arrest care, and the management of supraventricular tachycardia (SVT). The reviewed research reports address topics such as nutrition in critically ill adults, administration of β-lactams for severe sepsis, anticoagulant selection in the context of continuous renal replacement therapy, early goal-directed therapy in septic shock, magnesium use for neuroprotection in acute stroke, and progesterone use in patients with traumatic brain injury.
  
  
  
  Important recent additions to the critical care pharmacy literature include updated joint clinical practice guidelines on the management of spontaneous ICH, ACLS, and SVT.
authors.affiliation: Brigham and Women's Hospital/MCPHS University, Boston, MA awong22@partners.org.
authors.forename: Adrian
authors.initials: A
authors.lastname: Wong
authors.affiliation: University of Florida Health-Jacksonville, Jacksonville, FL.
authors.forename: Michael
authors.initials: M
authors.lastname: Erdman
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, AR.
authors.forename: Drayton A
authors.initials: DA
authors.lastname: Hammond
authors.affiliation: IU Health Methodist, Indianapolis, IN.
authors.forename: Tara
authors.initials: T
authors.lastname: Holt
authors.affiliation: Beaumont Hospital-Royal Oak, Royal Oak, MI.
authors.forename: Jenna M
authors.initials: JM
authors.lastname: Holzhausen
authors.affiliation: Henry Ford Hospital, Detroit, MI.
authors.forename: Michelle
authors.initials: M
authors.lastname: Horng
authors.affiliation: VA Medical Center, Ann Arbor, MI.
authors.forename: Lori Lynn
authors.initials: LL
authors.lastname: Huang
authors.affiliation: St. Mary's of Michigan, Saginaw, MI.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Jarvis
authors.affiliation: Duke University Hospital, Durham, NC.
authors.forename: Bridgette
authors.initials: B
authors.lastname: Kram
authors.affiliation: Medical and Cardiothoracic ICU, Duke University Medical Center, Durham, NC.
authors.forename: Shawn
authors.initials: S
authors.lastname: Kram
authors.affiliation: NeuroICU, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY.
authors.forename: Christine
authors.initials: C
authors.lastname: Lesch
authors.affiliation: Roper St. Francis Health Care, Charleston, SC.
authors.forename: Jessica
authors.initials: J
authors.lastname: Mercer
authors.affiliation: Loyola University Medical Center, Maywood, IL.
authors.forename: Megan A
authors.initials: MA
authors.lastname: Rech
authors.affiliation: UPMC Presbyterian, Pittsburgh, PA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Rivosecchi
authors.affiliation: Frederick Memorial Hospital, Frederick, MD.
authors.forename: Brian
authors.initials: B
authors.lastname: Stump
authors.affiliation: Hospital of Central Connecticut, New Britain, CT.
authors.forename: Colleen
authors.initials: C
authors.lastname: Teevan
authors.affiliation: Doctors Hospital OhioHealth, Columbus, OH.
authors.forename: Sarah
authors.initials: S
authors.lastname: Day
mesh_terms: D022561:Advanced Cardiac Life Support / Q000379:methods / Q000639:trends; D002543:Cerebral Hemorrhage / Q000628:therapy; D003422:Critical Care / Q000379:methods / Q000639:trends*; D016638:Critical Illness / Q000628:therapy*; D019317:Evidence-Based Medicine / Q000379:methods / Q000639:trends; D006801:Humans; D010506:Periodicals as Topic / Q000639:trends*; D017410:Practice Guidelines as Topic; D013617:Tachycardia, Supraventricular / Q000628:therapy
keywords: cardiology; critical care; drug therapy; neurology; nutrition therapy; review