title: Validation of a novel prognostic scoring system using inflammatory response biomarkers in patients undergoing curative thoracoscopic esophagectomy for esophageal squamous cell carcinoma.
abstract: BACKGROUND
  Systemic inflammatory markers, including the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio have been shown to predict postoperative recurrence and survival in various types of cancer. However, their role in esophageal cancer has yet to be determined. This study aimed to evaluate the prognostic significance of an inflammatory response biomarker (IRB) score, independent of conventional clinicopathological criteria, in patients with esophageal cancer undergoing curative resection.
  
  
  METHODS
  We retrospectively reviewed a database containing the medical records of 147 consecutive patients who underwent curative esophagectomy for esophageal squamous cell carcinoma. The IRB score was determined as follows: a low lymphocyte-to-monocyte ratio (<4), a low neutrophil-to-lymphocyte ratio (<1.6), and a high platelet-to-lymphocyte ratio (>147), which were each scored as 1, with all remaining values scored as 0. The scores were added together to produce the IRB score (range: 0-3).
  
  
  RESULTS
  An IRB score of 2-3 (hazard ratio: 6.023, 95% confidence interval: 1.675-13.078;P<0.01) was identified as an independent poor prognostic factor of cancer-specific survival (CSS) in a multivariate logic regression analysis. The 5-year CSS rates in patients with the IRB scores of 0-1, 2, and 3 were 37.8%, 67.8%, and 72.5%, respectively. As determined by Kaplan-Meier analysis and the log-rank test, these differences were significant (P<0.001).
  
  
  CONCLUSIONS
  The IRB score can predict the systemic inflammatory response as accurately as conventional tumor markers and is useful for determining CSS in patients with esophageal cancer undergoing curative thoracoscopic esophagectomy.
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Hirahara
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Fujii
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Hyakudomi
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirayama
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Taniura
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishitobi
authors.affiliation: Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Shimane, Japan.
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Tajima
keywords: IRB score; esophageal squamous cell carcinoma; inflammatory response biomarker score; lymphocyte-to-monocyte ratio; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; prognosis