title: The Association of Lesion Location and Sleep Related Breathing Disorder in Patients with Acute Ischemic Stroke.
abstract: OBJECTIVE
  Sleep related breathing disorders (SRBD) are common in patients with ischemic stroke and are associated with poor outcome. SRBD after stroke were assumed to be a direct consequence of injury of specific central nervous system structures. However, whether specific locations of ischemic infarcts cause SRBD is yet unknown. We therefore investigated the association of ischemic lesion location with SRBD.
  
  
  METHODS
  Patients with acute ischemic stroke treated on our stroke unit were included in a prospective observational study. All patients underwent magnetic resonance imaging (MRI) and polygraphy in the acute phase after stroke. SRBD was defined by an apnea-hypopnea index (AHI) ≥10. MRI were evaluated using standardized maps to depict voxel-wise probability distribution of infarction for patients with and without SRBD. Groups were compared using logistic regression analysis.
  
  
  RESULTS
  Of 142 patients included, 86 (59%) had a SRBD. Age, body mass index and prevalence of arterial hypertension were significantly higher in patients with SRBD. There was no statistically significant association between any lesion location and SRBD.
  
  
  CONCLUSIONS
  We found no association of lesion location and SRBD in stroke patients, whereas established risk factors for SRBD, known from general population, were significantly associated with SRBD. Given the high prevalence of SRBD in stroke patients, these findings suggest that cerebral ischemia facilitates the occurrence of SRBD in patients with pre-existing risk factors rather than causing it by damaging specific central nervous system structures. Our findings can be used to identify stroke patients who might benefit from polygraphy screening.
authors.affiliation: Department of Neurology, University of Muenster, Muenster, Germany.
authors.forename: Anna Lena
authors.initials: AL
authors.lastname: Fisse
authors.affiliation: Department of Neuroradiology, University of Luebeck, Luebeck, Germany.
authors.forename: André
authors.initials: A
authors.lastname: Kemmling
authors.affiliation: Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Teuber
authors.affiliation: Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Wersching
authors.affiliation: Department of Sleep Medicine and Neuromuscular Disorders, Muenster, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Young
authors.affiliation: Department of Neurology, University of Muenster, Muenster, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Dittrich
authors.affiliation: Department of Neurology, University of Muenster, Muenster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Ritter
authors.affiliation: Department of Neurology, University of Muenster, Muenster, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Dziewas
authors.affiliation: Department of Neurology, University of Muenster, Muenster, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Minnerup
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012891:Sleep Apnea Syndromes / Q000150:complications*; D020521:Stroke / Q000150:complications*