title: [Long-Term Survival of a Patient with Recurrent Duodenal GIST Treated with Various Molecular Targeted Drugs and TAE - A Case Report].
abstract: The patient was 66-year-old woman with anemia. A 6 cm GIST was diagnosed in the fourth portion of the duodenum using abdominal CT. Duodenal-jejunal segmental resection was performed for the GIST. Four years after surgery, multiple liver metastatic recurrences ofGIST were diagnosed using abdominal CT. The metastatic tumor was treated with imatinib, but the treatment caused adverse events such as leukocytopenia(Grade 2)and anemia(Grade 3). The treatment continued for 41 months while reduced or discontinued during the administration period. Sunitinib was administered, but the treatment caused a reduced platelet count(Grade 3), anemia(Grade 2), and melena(Grade 3). The treatment continued for 12 months while reduced or discontinued during the administration period. Regorafenib was administered and continued for 9 months. Thereafter, trancecatheter arterial embolization(TAE)was performed 5 times. The patient is alive 8 years and 3 months after recurrence.
authors.affiliation: Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.
authors.forename: Hikari
authors.initials: H
authors.lastname: Chidimatsu
authors.forename: Hiroto
authors.initials: H
authors.lastname: Matsui
authors.forename: Michihisa
authors.initials: M
authors.lastname: Iida
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kanekiyo
authors.forename: Yukio
authors.initials: Y
authors.lastname: Tokumitsu
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tokuhisa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takeda
authors.forename: Tomio
authors.initials: T
authors.lastname: Ueno
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Yoshino
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hazama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
mesh_terms: D000368:Aged; D018450:Disease Progression; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D004621:Embolization, Therapeutic; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D058990:Molecular Targeted Therapy