title: Altered amplitude of low frequency fluctuations in schizophrenia patients with persistent auditory verbal hallucinations.
abstract: The aim of this study is to analyze the differences in low frequency fluctuation (LFF) values between schizophrenia patients with and without auditory verbal hallucinations (AVH). Nineteen schizophrenia patients with persistent AVH (HP), fourteen non-hallucinating schizophrenia patients (nHP) and twenty healthy controls (HC) underwent R-fMRI. LFF values were calculated in the slow frequency band (0.01-0.08Hz). By means of group level contrasts, we performed direct voxel-wise group comparisons. Both groups of patients showed decreased amplitude LFF (ALFF) values in the occipital pole and lingual gyrus compared to HC, whereas increased ALFF values were found in the temporal pole and fusifom gyrus. Schizophrenia patients exhibited decreased fractional ALFF (fALFF) values in the precuneus, occipital pole and bilateral occipital cortex, and increased fALFF in the insula compared to HC. There were also differences between patients with and without AVH. (Ok to start with lower case?) fALFF values were higher in the putamen and insular cortex and lower in the frontal pole in HP compared to nHP and HC. ALFF increased in HP patients in the bilateral thalamus and bilateral parahippocampal gyrus, compared to nHP patients and HC. Our results suggest that altered dynamics in low-frequency fluctuations may play a key role in the neurophysiology of auditory hallucinations.
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain; Mental Health Networking Biomedical Research Center, CIBERSAM, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Alonso-Solís
authors.affiliation: Scientific Information Port (PIC), Autonomous University of Barcelona (UAB), High Energy Physics Institute (IFAE), Barcelona, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Vives-Gilabert
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain; Mental Health Networking Biomedical Research Center, CIBERSAM, Spain. Electronic address: mportella@santpau.cat.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Portella
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Rabella
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain; Mental Health Networking Biomedical Research Center, CIBERSAM, Spain.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Grasa
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Roldán
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Keymer-Gausset
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain.
authors.forename: Conrad
authors.initials: C
authors.lastname: Molins
authors.affiliation: Department of Neuroradiology, Santa Creu and Sant Pau Hospital, Autonomous University of Barcelona (UAB), Barcelona, Spain.
authors.forename: Fidel
authors.initials: F
authors.lastname: Núñez-Marín
authors.affiliation: Department of Neuroradiology, Santa Creu and Sant Pau Hospital, Autonomous University of Barcelona (UAB), Barcelona, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Gómez-Ansón
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain; Mental Health Networking Biomedical Research Center, CIBERSAM, Spain.
authors.forename: Enric
authors.initials: E
authors.lastname: Alvarez
authors.affiliation: Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB-SANT PAU), Santa Creu and Sant Pau Hospital; Autonomous University of Barcelona (UAB), Barcelona, Spain; Mental Health Networking Biomedical Research Center, CIBERSAM, Spain.
authors.forename: Iluminada
authors.initials: I
authors.lastname: Corripio
mesh_terms: D000328:Adult; D005260:Female; D006212:Hallucinations / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications* / Q000000981:diagnostic imaging; D013702:Temporal Lobe / Q000000981:diagnostic imaging
keywords: Auditory hallucinations; Low frequency fluctuations; Resting state fMRI; Schizophrenia