title: Cell culture-based biosensing techniques for detecting toxicity in water.
abstract: The significant increase of contaminants entering fresh water bodies calls for the development of rapid and reliable methods to monitor the aquatic environment and to detect water toxicity. Cell culture-based biosensing techniques utilise the overall cytotoxic response to external stimuli, mediated by a transduced signal, to specify the toxicity of aqueous samples. These biosensing techniques can effectively indicate water toxicity for human safety and aquatic organism health. In this review we account for the recent developments of the mainstream cell culture-based biosensing techniques for water quality evaluation, discuss their key features, potentials and limitations, and outline the future prospects of their development.
authors.affiliation: Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 133, 8600 Dübendorf, Switzerland.
authors.forename: Lu
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 133, 8600 Dübendorf, Switzerland; School of Architecture, Civil and Environmental Engineering (ENAC), EPF Lausanne, 1015 Lausanne, Switzerland; Institute of Biogeochemistry and Pollutant Dynamics, ETH Zürich, 8092 Zürich, Switzerland. Electronic address: kristin.schirmer@eawag.ch.
authors.forename: Kristin
authors.initials: K
authors.lastname: Schirmer
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D018929:Cell Culture Techniques; D005399:Fishes; D005618:Fresh Water; D006801:Humans; D018675:Toxicity Tests / Q000379:methods*; D014867:Water / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D060753:Water Quality
chemical_list: D014874:Water Pollutants, Chemical; D014867:Water