title: [An Autopsy Case of an Elderly Patient with Signet-Ring Cell Carcinoma of the Breast Derived from Lobular Carcinoma].
abstract: A 90-year-old woman was referred to our hospital because of abdominal distension and pretibial edema. No tumors were palpable in either breast. Her abdomen was distended and palpitation was noticed. Laboratory examination revealed hypercalcemia and elevated levels of tumor markers(PIVKA- II , CEA, CA19-9, SCC). Contrast-enhanced computed tomography(CT) showed pleural effusion and ascites, an approximately 17-mm high-contrast mass in the D area of the left breast, and osteolysis of the dorsal lumber spine. We initiated treatment for pleural effusion, ascites, and hypercalcemia. However, on her 11th day in the hospital, hematemesis was observed and the patient died. We suspected metastasis of a malignant tumor, but a primary lesion had not been identified; therefore, an autopsy was performed. Autopsy showed a 17-mm mass in the D area of the left breast. Histopathological examination showed the growth of a signet-ring cell tumor that was immunohistochemically ER-positive, PgR-positive, and E-cadherin-negative. The patient was diagnosed with primary signet-ring cell carcinoma of the breast derived from lobular carcinoma. We reported a rare case of primary signet-ring cell carcinoma of the breast with a review of literature.
authors.affiliation: Dept. of Surgery, Fuchu Hospital.
authors.forename: Gen
authors.initials: G
authors.lastname: Tsujio
authors.forename: Naoki
authors.initials: N
authors.lastname: Aomatsu
authors.forename: Seika
authors.initials: S
authors.lastname: Tei
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Yamakoshi
authors.forename: En
authors.initials: E
authors.lastname: Wang
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nagashima
authors.forename: Toshiki
authors.initials: T
authors.lastname: Hirakawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Iwauchi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nishii
authors.forename: Junya
authors.initials: J
authors.lastname: Morimoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Yasutake
authors.initials: Y
authors.lastname: Uchima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Harada
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kawano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D000369:Aged, 80 and over; D001344:Autopsy; D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D018279:Carcinoma, Signet Ring Cell / Q000556:secondary*; D005260:Female; D006801:Humans