title: Does parvovirus infection have a role in systemic lupus erythematosus?
abstract: We sought to evaluate a possible link between parvovirus B19 infection and the clinical and laboratory expression of systemic lupus erythematosus (SLE). SLE patients were examined to evaluate their clinical status and disease activity. A complete Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score was obtained for each patient. In addition, we determined the level of systemic involvement throughout the course of the disease. Blood levels of IgM and IgG antibodies to parvovirus B19, levels of anti-dsDNA, C3, and C4 were measured. A PCR real-time assay was used to determine the presence of parvovirus B19 genetic material. The viral genome was found in sera of 2 of 51(3.9%) patients with SLE. There was no correlation between viral serology and the clinical and serological parameters of the disease. More SLE patients with secondary antiphospholipid syndrome (APS) had IgG and IgM antibodies to the virus (p < 0.029 and p < 0.018, respectively). These patients also had a higher titer of IgG antibodies to parvovirus B19 compared to SLE patients without APS. In this group of SLE patients, no association was found between parvovirus infection and the presence or activity of SLE. The results of the study suggest an association between parvovirus infection and antibody production directed against phospholipids.
authors.affiliation: Department of Medicine E, Meir Medical Center, 44261, Kfar Saba, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Tami
authors.initials: T
authors.lastname: Hod
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Department of Medicine C, Wolfson Medical Center, Holon, Israel.
authors.forename: Giselle
authors.initials: G
authors.lastname: Zandman-Goddard
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Rheumatology Unit, Sheba Medical Center, Tel Hashomer Hospital, Ramat Gan, Israel.
authors.forename: Pnina
authors.initials: P
authors.lastname: Langevitz
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Central Virology Laboratory, Sheba Medical Center, Tel Hashomer Hospital, Ramat Gan, Israel.
authors.forename: Hagit
authors.initials: H
authors.lastname: Rudnic
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Central Virology Laboratory, Sheba Medical Center, Tel Hashomer Hospital, Ramat Gan, Israel.
authors.forename: Zehava
authors.initials: Z
authors.lastname: Grossman
authors.affiliation: Department of Medicine E, Meir Medical Center, 44261, Kfar Saba, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Pnina
authors.initials: P
authors.lastname: Rotman-Pikielny
authors.affiliation: Department of Medicine E, Meir Medical Center, 44261, Kfar Saba, Israel. levy.yair@clalit.org.il.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. levy.yair@clalit.org.il.
authors.forename: Yair
authors.initials: Y
authors.lastname: Levy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D004279:DNA, Viral / Q000032:analysis; D018450:Disease Progression; D016731:Erythema Infectiosum / Q000276:immunology / Q000821:virology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016732:Parvovirus B19, Human / Q000502:physiology*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; D003176:Complement C3; D003181:Complement C4; D004279:DNA, Viral
keywords: Antiphospholipid antibody; Antiphospholipid syndrome; Parvovirus b19; Systemic lupus erythematosus