title: The clinical characteristics and prognostic significance of AID, miR-181b, and miR-155 expression in adult patients with de novo B-cell acute lymphoblastic leukemia.
abstract: This study aimed to investigate clinical characteristics and prognostic significance of activation-induced cytidine deaminase (AID) gene, miR-181b and miR-155 expression in de novo adult B-cell acute lymphoblastic leukemia (B-ALL) patients. Results showed that AID and miR-155 expression were higher in B-ALL patients than healthy controls, while miR-181b expression was lower in B-ALL patients. In addition, Ph+B-ALLs had higher AID expression than Ph-B-ALLs, and its high expression was associated with BCR-ABL. Moreover, B-ALL patients with AIDhighor miR-181blowexpression had a shorter overall survival (OS). AIDhighwith miR-181blow, AIDhighwith miR-155low, miR-181blow, miR-155low, AIDhighwith miR-181blowand miR-155lowexpression were associated with shorter OS. Combination of the three molecules are more accurate predictors for unfavorable OS compared with univariate group. Therefore, AID, miR-181b and miR-155 provide clinical prognosis of adult de novo B-ALL patients and may refine their molecular risk classification.
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Guangquan
authors.initials: G
authors.lastname: Zhou
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Dong
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: b Laboratory of Oncology, The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Hua
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ling
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Xiaobao
authors.initials: X
authors.lastname: Xie
authors.affiliation: c Department of Hematology , Children's Hospital of Suzhou University , Suzhou , Jiangsu Province , PR China.
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Hu
authors.affiliation: d Laboratory of Leukemia, Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University , Suzhou , Jiangsu Province , PR China.
authors.forename: Jiannong
authors.initials: J
authors.lastname: Cen
authors.affiliation: a Department of Hematology , The Third Affiliated Hospital of Suzhou University, The First People's Hospital of Changzhou , Changzhou , Jiangsu Province , PR China.
authors.forename: Weiying
authors.initials: W
authors.lastname: Gu
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003564:Cytidine Deaminase / Q000235:genetics*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality*; D011379:Prognosis; D055815:Young Adult
chemical_list: C000608460:MIRN-181 microRNA, human; C524942:MIRN155 microRNA, human; D035683:MicroRNAs; D003564:Cytidine Deaminase
keywords: Activation-induced cytidine deaminase; B-cell acute lymphoblastic leukemia; miR-155; miR-181b