title: CBP/p300 Bromodomain Mediates Amyloid Formation.
abstract: Bromodomains are protein domains that serve as "readers" of acetylated lysine marks and mediate DNA-templated processes. In this issue of Cell Chemical Biology, Olzscha et al. (2017) report that the CBP/p300 bromodomains mediate the formation of amyloid-like aggregates and that inhibitors specific to these bromodomains reduce the degree of protein aggregation and mitigate HDAC inhibitor-induced cytotoxicity.
authors.affiliation: Department of Anatomy and Cell Biology, UF Health Cancer Center, University of Florida College of Medicine, Gainesville, FL 32610, USA. Electronic address: dliao@ufl.edu.
authors.forename: Daiqing
authors.initials: D
authors.lastname: Liao
mesh_terms: D000107:Acetylation; D008239:Lysine; D008958:Models, Molecular; D066329:Protein Aggregates; D000072417:Protein Domains
chemical_list: D066329:Protein Aggregates; D008239:Lysine