title: Peabody Picture Vocabulary Test: Proxy for Verbal IQ in Genetic Studies of Autism Spectrum Disorder.
abstract: This study assessed the utility of a brief assessment (the Peabody Picture Vocabulary Test-4th Edition; PPVT4) as a proxy for verbal IQ (VIQ) in large-scale studies of autism spectrum disorder (ASD). In a sample of 2,420 proband with ASD, PPVT4:IQ correlations were strong. PPVT4 scores were, on average, 5.46 points higher than VIQ; 79% of children had PPVT4 scores within one standard deviation (+/-15) of their VIQ and 90% were similarly classified as having abilities above or below 70 on both measures. Distributions of PPVT4 and VIQ by de novo mutation status were highly similar. These results strongly support the utility of PPVT4 as a proxy for VIQ in large-scale ASD studies, particularly for genetic investigations.
authors.affiliation: University of California San Francisco Department of Psychiatry, 1550 4th St, San Francisco, CA, 94158, USA.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Krasileva
authors.affiliation: University of California San Francisco Department of Psychiatry, 1550 4th St, San Francisco, CA, 94158, USA.
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Sanders
authors.affiliation: University of California San Francisco Department of Psychiatry, 1550 4th St, San Francisco, CA, 94158, USA. Vanessa.HusBal@ucsf.edu.|STAR Center for ASD & NDD, 401 Parnassus Ave, San Francisco, CA, 94143, USA. Vanessa.HusBal@ucsf.edu.
authors.forename: Vanessa Hus
authors.initials: VH
authors.lastname: Bal
mesh_terms: D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D007361:Intelligence Tests / Q000592:standards; D007807:Language Tests / Q000592:standards; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D014705:Verbal Behavior / Q000502:physiology*; D014825:Vocabulary
keywords: Autism spectrum disorder; Cognition; Intelligence tests; Language tests