title: MTHFR C677Tpolymorphism and breast, ovarian cancer risk: a meta-analysis of 19,260 patients and 26,364 controls.
abstract: OBJECTIVE
  Previous studies have found that many gene variations can be detected in both breast cancer and ovarian cancer, which is beneficial for the elaboration of the molecular origin of breast and ovarian cancer. Furthermore, many studies have explored the association of methylenetetrahydrofolate reductase (MTHFR)C677Tpolymorphism with the risk of breast cancer and/or ovarian cancer; however, the results remained inconclusive. Therefore, this study conducted a systematic review and meta-analysis to evaluate the association betweenMTHFR C677Tpolymorphism and the risk of breast and ovarian cancer.
  
  
  METHODS
  A total of 50 studies with 19,260 cases and 26,364 controls including 39 studies for breast cancer and 8 studies for ovarian cancer were identified on searching through PubMed, Embase, Web of Science, China National Knowledge Infrastructure, WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP). Allele model, dominant model, recessive model, homozygous model, and co-dominant model were applied to evaluate the association ofMTHFR C677Tpolymorphism with breast cancer and/or ovarian cancer risk. Moreover, the odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association betweenMTHFR C677Tpolymorphism and breast and ovarian cancer risk.
  
  
  RESULTS
  A significantly increased breast cancer risk was observed in the overall analysis (for C vs T, OR =1.19, CI: 1.12-1.28,P<0.05; for CC vs TT, OR =1.20, CI: 1.10-1.23,P<0.05; for (CT+CC) vs TT, OR =1.19, CI: 1.11-1.27,P<0.05; for CC vs (CT+TT), OR =1.19, CI: 1.79-1.95,P<0.05), while no significantly increased ovarian cancer risk was detected. In the subgroup analysis based on ethnicity, a significant association of breast cancer and/or ovarian cancer risk withMTHFR C677Tpolymorphism was observed in Asians. Interestingly, there was no significant association betweenMTHFR C677Tpolymorphism and ovarian cancer risk in Caucasians, whereas a significantly increased risk of breast cancer was found in Caucasians.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates thatMTHFR C677Tpolymorphism may be a risk factor for breast and ovarian cancer, especially in Asians.
authors.affiliation: Department of Oncology, The First People's Hospital of Tianmen City, Tianmen, Hubei Province, People's Republic of China.
authors.forename: Lilin
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Oncology, The First People's Hospital of Tianmen City, Tianmen, Hubei Province, People's Republic of China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Shen
keywords: C677T; MTHFR; breast cancer; meta-analysis; ovarian cancer; polymorphism