title: Underperforming Big Ideas in Biomedical Research-Reply.
authors.affiliation: Laboratory of Human Integrative Physiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyner
authors.affiliation: Department of Epidemiology and Biostatistics, Michigan State University, East Lansing.
authors.forename: Nigel
authors.initials: N
authors.lastname: Paneth
authors.affiliation: Department of Medicine, Stanford Prevention Research Center, Stanford, California.
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
mesh_terms: D035843:Biomedical Research; D006801:Humans