title: Ganotheaecolin A, a Neurotrophic Conjugated Ergosterol with a Naphtho[1,8-ef]azulene Scaffold from Ganoderma theaecolum.
abstract: Ganotheaecolin A (1), a novel ergosterol with a rare naphtho[1,8-ef]azulene ring system, was isolated from the fruiting bodies of Ganoderma theaecolum. Its structure was determined by spectroscopic data and computational methods. Compound 1 represents a 6/6/7/5-fused carbon skeletal ergosterol typically formed by Wagner-Meerwein rearrangement, whose plausible biosynthetic pathway was briefly discussed. Finally, the neurotrophic activity of 1 was examined using PC12 cells.
authors.affiliation: University of Chinese Academy of Sciences , Beijing 100049, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.forename: Zhu-Liang
authors.initials: ZL
authors.lastname: Yang
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.forename: Yong-Xian
authors.identifier: 0000-0002-1343-0806
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D000818:Animals; D052176:Azulenes; D004875:Ergosterol / Q000737:chemistry*; D048690:Fruiting Bodies, Fungal; D032902:Ganoderma; D015394:Molecular Structure; D016716:PC12 Cells; D051381:Rats
chemical_list: D052176:Azulenes; D004875:Ergosterol