title: Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials.
abstract: The advent of long-term remotely conducted clinical trials requires assessments which can be administered online. This paper considers the utility, reliability, sensitivity and validity of an internet-based system for measuring changes in cognitive function which is being used in one such trial.
  
  
  
  The Platform for Research Online to investigate Genetics and Cognition in Ageing is a 10-year longitudinal and entirely remote study launched in November 2015. The CogTrackTMSystem is being used to monitor changes in important aspects of cognitive function using tests of attention, information processing and episodic memory. On study entry, the participants performed CogTrackTMup to three times over seven days, and these data are evaluated in this paper.
  
  
  
  During the first six months of the study, 14 531 individuals aged 50 to 94 years enrolled and performed the CogTrackTMSystem, 8627 of whom completed three test sessions. On the first administration, 99.4% of the study tasks were successfully completed. Repeated testing showed training/familiarisation effects on four of the ten measures which had largely stabilised by the third test session. The factor structure of the various measures was found to be robust. Evaluation of the influence of age identified clinically relevant declines over the age range of the population on one or more measures from all tasks.
  
  
  
  The results of these analyses identify CogTrackTMto be a practical and valid method to reliably, sensitively, remotely and repeatedly collect cognitive data from large samples of individuals aged 50 and over. Copyright © 2017 John Wiley & Sons, Ltd.
authors.affiliation: Wesnes Cognition Ltd, Streatley on Thames, UK.|Medical School, Exeter University, UK.|Department of Psychology, Northumbria University, Newcastle, UK.|Centre for Human Psychopharmacology, Swinburne University, Australia.|Medicinal Plant Research Group, Newcastle University, UK.
authors.forename: Keith A
authors.identifier: 0000-0002-4498-8511
authors.initials: KA
authors.lastname: Wesnes
authors.affiliation: Wesnes Cognition Ltd, Streatley on Thames, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Brooker
authors.affiliation: Medical School, Exeter University, UK.|King's College London, UK.
authors.forename: Clive
authors.initials: C
authors.lastname: Ballard
authors.affiliation: King's College London, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: McCambridge
authors.affiliation: Manta Software Limited, Cambridge, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Stenton
authors.affiliation: Medical School, Exeter University, UK.|King's College London, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Corbett
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001288:Attention / Q000502:physiology; D002986:Clinical Trials as Topic / Q000379:methods*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D059026:Diagnostic Self Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009862:Online Systems; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires / Q000592:standards; D006113:United Kingdom
keywords: attention; memory; remote cognitive testing; the PROTECT study