title: Association of Psoriasis and Metabolic Syndrome in Latin America: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Meta-analyses have found evidence of a relationship between psoriasis and metabolic syndrome, but Latin American populations have not been included.
  
  
  METHODS
  We performed a systematic review and meta-analysis of observational studies including adults with psoriasis and metabolic syndrome indexed in Medline, Scopus, SciELO, Google Scholar, Science Direct, and LILACS between 1980 and 2016. We computed pooled odds ratios (OR) with a random effects model and analyzed subgroups according to patient variables used in the studies.
  
  
  RESULTS
  Five studies with a total of 241 patients with psoriasis were found; 46.5% of the patients also had metabolic syndrome (pooled OR, 2.63; 95% CI: 1.11-6.23; P=.03). In studies using the Adult Treatment Panel III (ATP-III) criteria for metabolic syndrome, the pooled OR was similar at 3.97 (95% CI: 1.27-21.42). Studies that included patients with chronic and severe disease detected higher risk for metabolic syndrome (pooled OR, 6.65; 95% CI: 3.32-13.31). Limitations are that few studies have been done in Latin America, heterogeneity was high, and inconsistency was found across studies.
  
  
  CONCLUSIONS
  The association between psoriasis and metabolic syndrome is high in Latin America. The association is stronger when psoriasis is chronic and severe and when the ATP-III criteria are used for diagnosis.
authors.affiliation: Servicio de Dermatología, Hospital Nacional Daniel Alcides Carrión, Callao, Perú; Universidad Nacional Mayor de San Marcos, Lima, Perú. Electronic address: milton_rz@hotmail.com.
authors.forename: M J M
authors.initials: MJM
authors.lastname: Rodríguez-Zúñiga
authors.affiliation: Servicio de Dermatología, Hospital Nacional Daniel Alcides Carrión, Callao, Perú.
authors.forename: F
authors.initials: F
authors.lastname: Cortez-Franco
authors.affiliation: Servicio de Dermatología, Hospital Nacional Daniel Alcides Carrión, Callao, Perú.
authors.forename: E
authors.initials: E
authors.lastname: Quijano-Gomero
mesh_terms: D000328:Adult; D015984:Causality; D015897:Comorbidity; D004198:Disease Susceptibility; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D008962:Models, Theoretical; D064887:Observational Studies as Topic; D016017:Odds Ratio; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology*; D012107:Research Design; D012306:Risk
keywords: Latin America; Latinoamérica; Meta-analysis; Metaanálisis; Metabolic syndrome; Psoriasis; Síndrome metabólico