title: A UK wide cohort study describing management and outcomes for infants with surgical Necrotising Enterocolitis.
abstract: The Royal College of Surgeons have proposed using outcomes from necrotising enterocolitis (NEC) surgery for revalidation of neonatal surgeons. The aim of this study was therefore to calculate the number of infants in the UK/Ireland with surgical NEC and describe outcomes that could be used for national benchmarking and counselling of parents. A prospective nationwide cohort study of every infant requiring surgical intervention for NEC in the UK was conducted between 01/03/13 and 28/02/14. Primary outcome was mortality at 28-days. Secondary outcomes included discharge, post-operative complication, and TPN requirement. 236 infants were included, 43(18%) of whom died, and eight(3%) of whom were discharged prior to 28-days post decision to intervene surgically. Sixty infants who underwent laparotomy (27%) experienced a complication, and 67(35%) of those who were alive at 28 days were parenteral nutrition free. Following multi-variable modelling, presence of a non-cardiac congenital anomaly (aOR 5.17, 95% CI 1.9-14.1), abdominal wall erythema or discolouration at presentation (aOR 2.51, 95% CI 1.23-5.1), diagnosis of single intestinal perforation at laparotomy (aOR 3.1 95% CI 1.05-9.3), and necessity to perform a clip and drop procedure (aOR 30, 95% CI 3.9-237) were associated with increased 28-day mortality. These results can be used for national benchmarking and counselling of parents.
authors.affiliation: National Perinatal Epidemiology Unit, Old Road Campus, Headington, Oxford, OX37LF, UK.|Department of Paediatric Surgery, Oxford Children's Hospital, Headley Way, Oxford, OX39DU, UK.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Allin
authors.affiliation: National Perinatal Epidemiology Unit, Old Road Campus, Headington, Oxford, OX37LF, UK.|Department of Paediatric Surgery, Oxford Children's Hospital, Headley Way, Oxford, OX39DU, UK.
authors.forename: Anna-May
authors.initials: AM
authors.lastname: Long
authors.affiliation: Neonatal Intensive Care Unit, Oxford Children's Hospital, Headley Way, Oxford, OX39DU, UK.
authors.forename: Amit
authors.initials: A
authors.lastname: Gupta
authors.affiliation: National Perinatal Epidemiology Unit, Old Road Campus, Headington, Oxford, OX37LF, UK.
authors.forename: Marian
authors.initials: M
authors.lastname: Knight
authors.affiliation: Department of Paediatric Surgery, Oxford Children's Hospital, Headley Way, Oxford, OX39DU, UK.
authors.forename: Kokila
authors.initials: K
authors.lastname: Lakhoo
mesh_terms: D019985:Benchmarking; D015331:Cohort Studies; D003376:Counseling; D020345:Enterocolitis, Necrotizing / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007494:Ireland; D007813:Laparotomy / Q000009:adverse effects; D008297:Male; D009026:Mortality; D010289:Parenteral Nutrition, Total / Q000706:statistics & numerical data; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D006113:United Kingdom