title: Photoredox-Catalyzed Reductive Carbamoyl Radical Generation: A Redox-Neutral Intermolecular Addition-Cyclization Approach to Functionalized 3,4-Dihydroquinolin-2-ones.
abstract: The first reductive generation of carbamoyl radicals using photoredox catalysis for their formation is reported. This approach facilitated the development of a redox-neutral synthesis of functionalized 3,4-dihydroquinolin-2-ones via the novel intermolecular addition-cyclization of carbamoyl radicals across electron-deficient alkenes. To illustrate the versatility of this reaction, a diverse collection of 3,4-dihydroquinolin-2-ones, including fused cyclic and spirocyclic systems inspired by natural products, has been prepared.
authors.affiliation: Department of Chemistry, University of York , York YO10 5DD, U.K.
authors.forename: Wade F
authors.initials: WF
authors.lastname: Petersen
authors.affiliation: Department of Chemistry, University of York , York YO10 5DD, U.K.
authors.forename: Richard J K
authors.initials: RJ
authors.lastname: Taylor
authors.affiliation: Department of Chemistry, University of York , York YO10 5DD, U.K.
authors.forename: James R
authors.identifier: 0000-0002-2176-4902
authors.initials: JR
authors.lastname: Donald