title: The Association Between Liver and Tumor [18F]FDG Uptake in Patients with Diffuse Large B Cell Lymphoma During Chemotherapy.
abstract: The aim of this study was to explore the association between liver, mediastinum and tumor 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake during chemotherapy in diffuse large B cell lymphoma (DLBCL).
  
  
  
  Nineteen patients with proven DLBCL underwent positron emission tomography (PET)/X-ray computed tomography scan at baseline, 1 week and 2 cycles after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) therapy, and again after chemotherapy completion. The mean and maximal standardized uptake value (SUVmean and SUVmax) of the liver and mediastinum were measured and correlated with the tumor SUVmax, SUVsum, whole-body metabolic tumor volume (MTVwb), and total lesion glycolysis (TLG).
  
  
  
  At baseline, both the liver and mediastinum SUVmean and SUVmax correlated inversely with the tumor MTVwb or TLG (p < 0.01 or 0.001). The liver SUVmean and SUVmax increased significantly after 1 week of R-CHOP therapy and remained at the high level until chemotherapy completion. The mediastinum SUVmean and SUVmax remained stable during chemotherapy. The tumor SUVmax, SUVsum, MTVwb, and TLG decreased significantly after 1 week of R-CHOP therapy. The change of the liver SUVmean correlated inversely with the change of tumor MTVwb and TLG after 1 week of chemotherapy (p < 0.05, respectively). The intersubject variability of liver and mediastinum [18F]FDG uptake ranged from 11 to 26 %.
  
  
  
  The liver [18F]FDG uptake increased significantly after R-CHOP therapy. One of the possible reasons is the distribution of a greater fraction of the tracer to healthy tissues rather than tumor after effective chemotherapy. The variability of the liver [18F]FDG uptake during chemotherapy might affect the visual analysis of the interim PET scan and this needs to be confirmed in future studies with a large patient cohort. In addition, the intersubject variability of the liver and mediastinum [18F]FDG uptake should be considered.
authors.affiliation: Department of Oncology, Tampere University Hospital, Tampere, Finland. Xingchen.Wu@uta.fi.|Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Xingchen.Wu@uta.fi.
authors.forename: Xingchen
authors.initials: X
authors.lastname: Wu
authors.affiliation: Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland.|Faculty of Biomedical Engineering, Tampere University of Technology, Tampere, Finland.
authors.forename: Abhisek
authors.initials: A
authors.lastname: Bhattarai
authors.affiliation: Medical Imaging Centre, Department of Nuclear Medicine, Tampere University Hospital, Tampere, Finland.
authors.forename: Pasi
authors.initials: P
authors.lastname: Korkola
authors.affiliation: Department of Oncology, Tampere University Hospital, Tampere, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Pertovaara
authors.affiliation: Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland.|Faculty of Biomedical Engineering, Tampere University of Technology, Tampere, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Eskola
authors.affiliation: Department of Oncology, Tampere University Hospital, Tampere, Finland.|Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
authors.forename: Pirkko-Liisa
authors.initials: PL
authors.lastname: Kellokumpu-Lehtinen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003710:Demography; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008111:Liver Function Tests; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents; D019788:Fluorodeoxyglucose F18
keywords: DLBCL; Liver; MTV; Mediastinum; PET/CT; SUV; TLG; [18F]FDG