title: Antiproliferative Activity of Natural Taiwaniaquinoids and Related Compounds.
abstract: The in vitro antiproliferative activities of some taiwaniaquinoids and related compounds with functionalized A, B, or C rings against human breast (MCF-7), colon (T-84), and lung (A-549) tumor cell lines were assayed. The most potent compounds, 16, 27, and 36, were more effective than the naturally occurring taiwaniaquinones A (4) and F (5) in all three cell lines. The structure-activity relationship study of these new taiwaniaquinoids highlighted the correlation between the bromo substituent and the antiproliferative activity, especially in MCF-7 cells. These findings indicate that some of the taiwaniaquinoids might be useful as cytostatic agents against breast, colon, and lung cancer cell lines.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Guardia
authors.forename: Rubén
authors.initials: R
authors.lastname: Tapia
authors.affiliation: Laboratory Productions, Plant and Microbial Valuations (LP2VM), Department of Biotechnology, University of Sciences and Technology of Oran Mohamed Boudiaf , BP 1525, El M'Naouer, Oran, Algeria.
authors.forename: Soumicha
authors.initials: S
authors.lastname: Mahdjour
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodriguez-Serrano
authors.forename: Nuria
authors.initials: N
authors.lastname: Mut-Salud
authors.forename: Rachid
authors.initials: R
authors.lastname: Chahboun
authors.forename: Enrique
authors.identifier: 0000-0002-3659-4475
authors.initials: E
authors.lastname: Alvarez-Manzaneda
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D013237:Stereoisomerism; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes