title: Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment.
abstract: L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review.
authors.affiliation: Keitaro Hayashi, Naohiko Anzai, Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Keitaro Hayashi, Naohiko Anzai, Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, Japan.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Anzai
keywords: Amino acid starvation response; Amino acid transporter; LAT1; Molecular target drug; Signal transduction