title: Eyelid Eccrine Cyst: An Exceptional Lesion Among Dominant Apocrine Cysts.
abstract: A 71-year-old woman developed a small bluish lesion beneath the cilia of the left lower eyelid. Excision and microscopic examination disclosed a cyst with an intimately associated eccrine sweat gland. Immunohistochemistry demonstrated that the cyst's epithelium was strongly CK5/6, CK14, CK7 weakly positive, and gross cystic disease fluid protein-15 and smooth muscle actin negative. This is the first immunohistochemically proven eccrine cyst of the eyelid skin. Apocrine cysts develop only at the eyelid margin where the glands of Moll are located. They immunostain positively for cytoplasmic gross cystic disease fluid protein-15 in the adlumenal cells and smooth muscle actin in an outer myoepithelial (abluminal) layer.
authors.affiliation: *David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; and †Albert Einstein School of Medicine, Bronx, New York, U.S.A.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Jakobiec
authors.forename: Sana
authors.initials: S
authors.lastname: Qureshi
authors.forename: Fouad R
authors.initials: FR
authors.lastname: Zakka
authors.forename: Yufei
authors.initials: Y
authors.lastname: Tu
authors.forename: Nhayoung Grace
authors.initials: NG
authors.lastname: Lee
mesh_terms: D000368:Aged; D001050:Apocrine Glands / Q000473:pathology*; D001706:Biopsy; D003560:Cysts / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000473:pathology*; D005141:Eyelid Diseases / Q000175:diagnosis*; D005143:Eyelids / Q000473:pathology*; D005260:Female; D006801:Humans