title: Apolipoprotein E polymorphisms increase the risk of post-stroke depression.
abstract: Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whetherAPOEaffects post-stroke depression. Accordingly, we hypothesized thatAPOEpolymorphisms modify the risk of post-stroke depression. Here, we performed a hospital-based case-control study (including 76 cerebral infarction cases with post-stroke depression, 88 cerebral infarction cases without post-stroke depression, and 109 controls without any evidence of post-stroke depression or cerebral infarction) to determine possible association betweenAPOErs429358 and rs7412 polymorphisms and risk of post-stroke depression. Our findings show no difference among the groups with regards genotype distribution of the rs7412 polymorphism. In contrast,APOEgenotypes with rs429358-C alleles increased the risk of post-stroke depression. Further, the rs429358 polymorphism was associated with significantly decreased regional cerebral blood flow values in the left temporal lobe of post-stroke depression cases. Additionally, the rs429358 polymorphism was not only associated with depression severity, but with increasing serum levels of total cholesterol. These results suggest that theAPOErs429358 polymorphism is associated with increased risk of developing post-stroke depression, and thatAPOErs429358-C allele genotypes may be detrimental to recovery of nerve function after stoke. Indeed, these findings provide clinical data for future post-stroke depression gene interventions.
authors.affiliation: Stroke Center & Neurology Division, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China; Department of Neurology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.
authors.forename: Xue-Bin
authors.initials: XB
authors.lastname: Li
authors.affiliation: Department of Nephrology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Stroke Center & Neurology Division, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China.
authors.forename: An-Ding
authors.identifier: 0000-0003-3154-0985
authors.initials: AD
authors.lastname: Xu
authors.affiliation: Department of Neurology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Huang
authors.affiliation: Department of Neurology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.
authors.forename: Lan-Qing
authors.initials: LQ
authors.lastname: Meng
authors.affiliation: Department of Neurology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.
authors.forename: Rui-Ya
authors.initials: RY
authors.lastname: Huang
authors.affiliation: Department of Laboratory Medicines, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Wang
keywords: apolipoprotein E; cerebral infarction; genetic polymorphism; nerve regeneration; neural regeneration; post-stroke depression; regional resting-state cerebral blood flow; risk; rs429358; rs7412