title: Facile fabrication of a magnetically smart PTX-loaded Cys-Fe3O4/CuS@BSA nano-drug for imaging-guided chemo-photothermal therapy.
abstract: In this study, a multifunctional nano-drug (PTX-loaded Cys-Fe3O4/CuS@BSA nanocomposite), which performs well in hydrophobic drug delivery, magnetic resonance imaging (MRI) and chemo-photothermal combination therapy, has been successfully synthesized via a facile method with several biocompatible agents. The characterization verified that our as-obtained nanocarrier has a preferable average diameter of about 300 nm for cancer therapy, shows a great MRI ability and magnetism performance, and exhibits a favorable in vitro and in vivo photothermal therapeutic efficacy by introducing CuS, and the sustained release of chemotherapeutics could be controlled by pH value and near-infrared laser irradiation has further enhanced the therapeutic performance. Overall, the excellent synergistic effect to inhibit tumor growth effectively realized via imaging-guided combinational chemo-photothermal therapy in the present work, highlights the promise of conquering the limitations of tumor treatments.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Lanfang
authors.initials: L
authors.lastname: Ren
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Xijian
authors.identifier: http://orcid.org/0000-0001-5856-9142
authors.initials: X
authors.lastname: Liu
authors.affiliation: Orthopedic Traumatology, Trauma Center, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Orthopedic Traumatology, Trauma Center, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, P. R. China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Deng
authors.affiliation: Orthopedic Traumatology, Trauma Center, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, P. R. China and First School of Clinical Medicine, Nanjing Medical University, Nanjing, 211166, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
mesh_terms: D003300:Copper / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D060328:Magnetic Phenomena; D049329:Nanostructures / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry* / Q000627:therapeutic use; D010789:Phototherapy; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D012710:Serum Albumin, Bovine; D003300:Copper; C017846:cupric sulfide; D017239:Paclitaxel; D052203:Ferrosoferric Oxide