title: Impact of transjugular intrahepatic porto-systemic shunt on post liver transplantation outcomes: Study based on the United Network for Organ Sharing database.
abstract: OBJECTIVE
  To determine the impact of transjugular intrahepatic porto-systemic shunt (TIPS) on post liver transplantation (LT) outcomes.
  
  
  METHODS
  Utilizing the United Network for Organ Sharing (UNOS) database, we compared patients who underwent LT from 2002 to 2013 who had underwent TIPS to those without TIPS for the management of ascites while on the LT waitlist. The impact of TIPS on 30-d mortality, length of stay (LOS), and need for re-LT were studied. For evaluation of mean differences between baseline characteristics for patients with and without TIPS, we used unpairedt-tests for continuous measures and χ2tests for categorical measures. We estimated the impact of TIPS on each of the outcome measures. Multivariate analyses were conducted on the study population to explore the effect of TIPS on 30-d mortality post-LT, need for re-LT and LOS. All covariates were included in logistic regression analysis.
  
  
  RESULTS
  We included adult patients (age ≥ 18 years) who underwent LT from May 2002 to September 2013. Only those undergoing TIPS after listing and before liver transplant were included in the TIPS group. We excluded patients with variceal bleeding within two weeks of listing for LT and those listed for acute liver failure or hepatocellular carcinoma. Of 114770 LT in the UNOS database, 32783 (28.5%) met inclusion criteria. Of these 1366 (4.2%) had TIPS between the time of listing and LT. We found that TIPS increased the days on waitlist (408 ± 553 d) as compared to those without TIPS (183 ± 330 d),P< 0.001. Multivariate analysis showed that TIPS had no effect on 30-d post LT mortality (OR = 1.26; 95%CI: 0.91-1.76) and re-LT (OR = 0.61; 95%CI: 0.36-1.05). Pre-transplant hepatic encephalopathy added 3.46 d (95%CI: 2.37-4.55,P< 0.001), followed by 2.16 d (95%CI: 0.92-3.38,P= 0.001) by TIPS to LOS.
  
  
  CONCLUSIONS
  TIPS did increase time on waitlist for LT. More importantly, TIPS was not associated with 30-d mortality and re-LT, but it did lengthen hospital LOS after transplantation.
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Khalid
authors.initials: K
authors.lastname: Mumtaz
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Sherif
authors.initials: S
authors.lastname: Metwally
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Rohan M
authors.initials: RM
authors.lastname: Modi
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Nishi
authors.initials: N
authors.lastname: Patel
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Tumin
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Michaels
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: James
authors.initials: J
authors.lastname: Hanje
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Ashraf
authors.initials: A
authors.lastname: El-Hinnawi
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.affiliation: Khalid Mumtaz, Anthony J Michaels, James Hanje, Wexner Medical Center, Gastroenterology, Hepatology and Nutrition Division, the Ohio State University, Columbus, OH 43210, United States.
authors.forename: Sylvester M
authors.initials: SM
authors.lastname: Black
keywords: Ascites; Liver; Model for end-stage liver disease; Mortality; Shunt; Transjugular; Transjugular intrahepatic porto-systemic shunt; Transplantation