title: Similar change in platelets and leucocytes 24 h after injury is associated with septic shock a week later.
abstract: BACKGROUND
  Septic shock is a severe complication in polytrauma patients. Early identification of patients at risk can guide future prevention strategies. Platelets (PLTs) and leucocytes presumably play an important role in the post-injury inflammatory response. The role of early changes in PLT and leucocyte counts was investigated in search for the aetiology of the development of septic complications.
  
  
  METHODS
  Polytrauma patients (aged 16-80 years) admitted to the intensive care unit with an expected stay of at least 3 days were included. PLT and leucocyte counts were measured on a daily basis for 14 days.
  
  
  RESULTS
  A total of 41 patients were included, of whom nine (22%) developed septic shock. There was no difference in (New) Injury Severity Score or Acute Physiology and Chronic Health Evaluation II scores between patients who developed septic shock and patients who did not. Three patients died, one of them in septic shock. Patients who developed septic shock during hospital stay had lower PLTs and a slower recovery to normal PLT counts than patients without septic shock. Patients who developed either a decrease in both PLTs and leucocytes or an increase in PLTs and leucocytes in the first 24 h after trauma were more likely to develop septic shock. This correlation was not found in patients who did not develop septic shock.
  
  
  CONCLUSIONS
  A similar change in PLT and leucocyte counts in the first 24 h after trauma is associated with the development of septic shock after a week. This indicates an early interaction between PLTs and leucocytes, which needs further investigation to gain more insight in the aetiology of post-injury septic complications.
authors.affiliation: Department of Trauma Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Saskia
authors.initials: S
authors.lastname: Jol
authors.affiliation: Department of Trauma Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Falco
authors.initials: F
authors.lastname: Hietbrink
authors.affiliation: Department of Trauma Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Luke P H
authors.initials: LP
authors.lastname: Leenen
authors.affiliation: Department of Respiratory Medicine and Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Leo
authors.initials: L
authors.lastname: Koenderman
authors.affiliation: Department of Trauma Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Karlijn J P
authors.initials: KJ
authors.lastname: van Wessem
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000473:pathology*; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007362:Intensive Care Units; D007958:Leukocyte Count; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood*; D010976:Platelet Count; D012772:Shock, Septic / Q000097:blood*; D055815:Young Adult
keywords: platelet and leucocyte correlation; septic shock; trauma