title: [Neuron specific enolase as a measure of the efficacy of mexidol in patients with neurologic complications of primary hypothyroidism].
abstract: OBJECTIVE
  To evaluate the activity of neuron specific enolase (NSE) in patients with primary hypothyroidism (PGT) treated with mexidol.
  
  
  METHODS
  Patients with PGT (n=110) were examined before and after treatment. Neuropsychological and neurological status of the patients was studied. To assess the status of the peripheral nervous system, electroneuromyography was performed and serum NSE level was determined.
  
  
  CONCLUSIONS
  The NSE activity depended on gender, age of the patient, duration of endocrinopathy and presence/absence of neurological symptoms. The clear positive dynamics of the majority of the parameters studied was noted during mexidol treatment. The efficacy of antioxidant therapy in these patients was confirmed.
authors.affiliation: Razumovsky Saratov State Medical University, Saratov, Russia.
authors.forename: E B
authors.initials: EB
authors.lastname: Kuznetsova
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D007159:Immunologic Tests; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D010847:Picolines / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D010847:Picolines; C070020:emoxypine succinate; D010751:Phosphopyruvate Hydratase