title: In vitro evaluation of Selective Inhibitors of Nuclear Export (SINE) drugs KPT-185 and KPT-335 against canine mammary carcinoma and transitional cell carcinoma tumor initiating cells.
authors.affiliation: Small Animal Clinical Sciences, Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Grayton
authors.affiliation: Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: T
authors.initials: T
authors.lastname: Miller
authors.affiliation: Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: H
authors.initials: H
authors.lastname: Wilson-Robles
mesh_terms: D000178:Acrylamides / Q000494:pharmacology / Q000627:therapeutic use*; D000179:Acrylates / Q000494:pharmacology / Q000627:therapeutic use*; D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000662:veterinary*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006834:Hydrazines / Q000494:pharmacology / Q000627:therapeutic use*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000178:Acrylamides; D000179:Acrylates; D000970:Antineoplastic Agents; D006834:Hydrazines; C576639:KPT-185; D014230:Triazoles; C000593855:verdinexor
keywords: cell signalling; in vitro models; oncology; stem cells; tumour biology