title: The DSM5/RDoC debate on the future of mental health research: implication for studies on human stress and presentation of the signature bank.
abstract: In 2008, the National Institute of Mental Health (NIMH) announced that in the next few decades, it will be essential to study the various biological, psychological and social "signatures" of mental disorders. Along with this new "signature" approach to mental health disorders, modifications of DSM were introduced. One major modification consisted of incorporating a dimensional approach to mental disorders, which involved analyzing, using a transnosological approach, various factors that are commonly observed across different types of mental disorders. Although this new methodology led to interesting discussions of the DSM5 working groups, it has not been incorporated in the last version of the DSM5. Consequently, the NIMH launched the "Research Domain Criteria" (RDoC) framework in order to provide new ways of classifying mental illnesses based on dimensions of observable behavioral and neurobiological measures. The NIMH emphasizes that it is important to consider the benefits of dimensional measures from the perspective of psychopathology and environmental influences, and it is also important to build these dimensions on neurobiological data. The goal of this paper is to present the perspectives of DSM5 and RDoC to the science of mental health disorders and the impact of this debate on the future of human stress research. The second goal is to present the "Signature Bank" developed by the Institut Universitaire en Santé Mentale de Montréal (IUSMM) that has been developed in line with a dimensional and transnosological approach to mental illness.
authors.affiliation: a Centre for Studies on Human Stress , CIUSSS Est , Quebec , Canada.|b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.|c Department of Psychiatry, Faculty of Medicine , University of Montreal , Montreal , Canada.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lupien
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.|c Department of Psychiatry, Faculty of Medicine , University of Montreal , Montreal , Canada.
authors.forename: M
authors.initials: M
authors.lastname: Sasseville
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.
authors.forename: N
authors.initials: N
authors.lastname: François
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.
authors.forename: C E
authors.initials: CE
authors.lastname: Giguère
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.
authors.forename: J
authors.initials: J
authors.lastname: Boissonneault
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.|d Department of Psychoeducation, Faculty of Arts and Sciences , University of Montreal , Montreal , Canada.
authors.forename: P
authors.initials: P
authors.lastname: Plusquellec
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.|c Department of Psychiatry, Faculty of Medicine , University of Montreal , Montreal , Canada.
authors.forename: R
authors.initials: R
authors.lastname: Godbout
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.|c Department of Psychiatry, Faculty of Medicine , University of Montreal , Montreal , Canada.
authors.forename: L
authors.initials: L
authors.lastname: Xiong
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.|c Department of Psychiatry, Faculty of Medicine , University of Montreal , Montreal , Canada.
authors.forename: S
authors.initials: S
authors.lastname: Potvin
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.
authors.forename: E
authors.initials: E
authors.lastname: Kouassi
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.|c Department of Psychiatry, Faculty of Medicine , University of Montreal , Montreal , Canada.
authors.forename: A
authors.initials: A
authors.lastname: Lesage
authors.affiliation: b Research Centre , Montreal Mental Health University Institute, CIUSSS Est , Quebec , Canada.
mesh_terms: D004777:Environment; D006801:Humans; D008603:Mental Health; D009315:National Institute of Mental Health (U.S.); D011599:Psychopathology; D012106:Research; D013315:Stress, Psychological; D014481:United States
keywords: DSM5; Mental health; RDoC; biological signature; development; developmental psychopathology; dimensions; environment