title: [Evaluation of Bevacizumab in Combination with Weekly Paclitaxel for Locally Advanced Breast Cancer].
abstract: Locally advanced breast cancer that exhibits bleeding, has a foul odor, and expresses an exudate often reduces the quality of life(QOL). Bevacizumab(Bv)in combination with weekly paclitaxel(PTX)therapy has a high response rate. To date, we have used this combination for 8 cases of locally advanced breast cancer in our hospital. The patients' mean age was 62.1 years. The tumors were T4b in 6 cases, T4c in 1 case and T4d in 1 case. The clinical stage was Stage III B in 1 case and Stage IV in 7 cases. The subtype was Luminal A in 2 cases, Luminal B in 4 cases, and triple negative in 2 cases. The mean dosage duration was 5.8 months. Five cases underwent local control operations after chemotherapy. One case showed a complete response, 4 cases had a partial response, 2 cases had a stable disease and 1 case had progressive disease. Four cases with Grade 2-3 hypertension and 4 cases with Grade 2 neutropenia were identified. Bvin combination with weekly PTX therapy had a high response rate, and 5 patients were able to undergo surgery. As QOL improved after treatment and the safety did not have any problem, Bv in combination with weekly PTX therapy is one of the effective treatments for locally advanced breast cancer.
authors.affiliation: Dept. of Surgery, Soka Municipal Hospital.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Fukuichiro
authors.initials: F
authors.lastname: Orita
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kume
authors.forename: Hironobu
authors.initials: H
authors.lastname: Baba
authors.forename: Yuya
authors.initials: Y
authors.lastname: Sato
authors.forename: Naoaki
authors.initials: N
authors.lastname: Hoshino
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Nishioka
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D000068258:Bevacizumab; D017239:Paclitaxel