title: Repeated Administrations of Rituximab along with Steroids and Immunosuppressive Agents in Refractory Steroid-resistant Nephrotic Syndrome.
abstract: BACKGROUND
  A recent randomized control trial in children with steroid-resistant nephrotic syndrome revealed that two doses of rituximab did not reduce proteinuria.
  
  
  METHODS
  A 14-month-old boy developed refractory steroid-resistant nephrotic syndrome due to focal segmental glomerulosclerosis.
  
  
  METHODS
  The patient achieved complete remission 11 months after disease onset following eight doses of rituximab combined with steroids and cyclosporine.
  
  
  CONCLUSIONS
  Long-lasting B cell depletion with repeated rituximab administrations may be required to achieve complete remission in patients with steroid-resistant nephrotic syndrome and massive proteinuria.
authors.affiliation: Division of Nephrology, Saitama Childrens Medical Center and *Department of Pediatrics, Juntendo University School of Medicine; Japan. Correspondence to: Dr Shuichiro Fujinaga, Division of Nephrology, Saitama Childrens Medical Center, 2100 Magome, Iwatsuki-ku, Saitama-city Saitama 339 8551, Japan. f_shuich@d2.dion.ne.jp.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Fujinaga
authors.forename: Koji
authors.initials: K
authors.lastname: Sakuraya
mesh_terms: D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D000069283:Rituximab / Q000008:administration & dosage / Q000627:therapeutic use; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D000069283:Rituximab