title: Development of a peptide conjugate vaccine for inducing therapeutic anti-IgE antibodies.
abstract: Given the multifaceted effector functions of IgE in immediate hypersensitivity, late-phase reactions, regulation of IgE receptor expression and immune modulation, IgE antibodies have long represented an attractive target for therapeutic agents in asthma and other allergic diseases. Effective pharmacologic blockade of the binding of IgE to its receptors has become one of most innovative therapeutic strategies in the field of allergic diseases in the last 10 years. Areas covered: The latest strategies targeting IgE include the development of a therapeutic vaccine, able to trigger our own immune systems to produce therapeutic anti-IgE antibodies, potentially providing a further step forward in the treatment of allergic diseases. The aim of this review is to discuss the discovery strategy, preclinical and early clinical development of a peptide conjugate vaccine for inducing therapeutic anti-IgE antibodies. Expert opinion: Outside the area of development of humanized anti-IgE monoclonal antibodies, the research field of therapeutic IgE-targeted vaccines holds potential benefits for the treatment of allergic diseases. However, most of the experimental observations in animal models have not yet been translated into new treatments and evidence of human efficacy and safety of this new therapeutic strategy are still lacking.
authors.affiliation: a Department of Pediatrics , Foundation IRCCS Policlinico San Matteo, University of Pavia , Pavia , Italy.
authors.forename: Amelia
authors.initials: A
authors.lastname: Licari
authors.affiliation: a Department of Pediatrics , Foundation IRCCS Policlinico San Matteo, University of Pavia , Pavia , Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Castagnoli
authors.affiliation: a Department of Pediatrics , Foundation IRCCS Policlinico San Matteo, University of Pavia , Pavia , Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: De Sando
authors.affiliation: a Department of Pediatrics , Foundation IRCCS Policlinico San Matteo, University of Pavia , Pavia , Italy.
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000276:immunology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000276:immunology; D002986:Clinical Trials as Topic / Q000379:methods; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D000069444:Omalizumab / Q000276:immunology / Q000627:therapeutic use; D018074:Vaccines, Conjugate / Q000276:immunology / Q000627:therapeutic use*; D022223:Vaccines, Subunit / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018074:Vaccines, Conjugate; D022223:Vaccines, Subunit; C026408:anti-IgE antibodies; D000069444:Omalizumab; D007073:Immunoglobulin E
keywords: IgE; adjuvants; allergy; anti-IgE; asthma; omalizumab; vaccine; virus-like particles