title: A very unusual case of food allergy, between FPIES and IgE-mediated food allergy.
abstract: Food protein induced enterocolitis syndrome (FPIES) is a food-related gastrointestinal hypersensitivity disorder, probably non-IgE-mediated. Over the years, various diagnostic criteria have been proposed to identify FPIES. In the last few years, there was an increased interest from researchers about FPIES's syndrome, that frequently brought to discover new aspects of this disease. We describe an unusual case of FPIES to egg in a 21-months-old child, because of its clinical characteristics that reflect some aspects of IgE-mediated allergy and other of non IgE-mediated allergy. Although we believe that the most correct diagnosis for our case is FPIES, we think also that this is undoubtedly an atypical form. This is in fact, the first description of a patient who simultaneously has both clinical expressions of IgE-mediated FA that of FPIES. Our case highlights the need to review criteria for FPIES diagnosis.
authors.affiliation: Allergy Unit, Department of Paediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy. Phone: +39 06 301 562 83 Fax: +39 06 338 32 11 E-mail: stefano.micelisopo@unicatt.it - stefano.micelisopo@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Miceli Sopo
authors.affiliation: Allergy Unit, Department of Paediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Monaco
authors.affiliation: Allergy Unit, Department of Paediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cerchiara
authors.affiliation: Allergy Unit, Department of Paediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bersani
mesh_terms: D004044:Dietary Proteins / Q000009:adverse effects*; D021181:Egg Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D004760:Enterocolitis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007223:Infant; D008297:Male; D012882:Skin Tests; D013577:Syndrome
chemical_list: D004044:Dietary Proteins; D007073:Immunoglobulin E
keywords: Diagnosis; IgE-mediated food allergy; egg; food protein induced enterocolitis syndrome