title: Tumor Necrosis Factor-αT-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis.
abstract: Objectives. To investigate the potential association of tumor necrosis factor-αT-857C polymorphism with susceptibility to the five common malignant tumors.Materials and Methods. A comprehensive search of PubMed/Medline, Embase, and Web of Science databases was performed up to November 2015. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis, heterogeneity analyses, and publication bias were also texted in the meta-analysis.Results. A total of twenty-two publications involving 5215 cases and 6755 controls were recruited. Overall, the meta-analysis revealed an increased risk between the TNF-αT-857C polymorphism and gastric cancer susceptibility in T versus C model, heterozygote genetic model, and dominant genetic model. An increased risk between the TNF-αT-857C polymorphism and hepatocellular cancer susceptibility in homozygote genetic model and recessive genetic model was also found. No significant association was found between the TNF-αT-857C polymorphism and colorectal cancer, cervical cancer, and prostate cancer.Conclusions. Our meta-analyses suggest that TNF-αT-857C polymorphism may be associated with increased risk of gastric cancer and hepatocellular cancer development. Therefore, the TNF-αT-857C polymorphism could be considered as one possible risk factor of gastric cancer and hepatocellular cancer according to our study.
authors.affiliation: Department of Clinical Laboratory and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Ping
authors.identifier: 0000-0002-1653-5961
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.
authors.forename: June
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Mingxia
authors.identifier: 0000-0002-0529-0030
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Zhiqiang
authors.identifier: 0000-0003-0144-8790
authors.initials: Z
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha