title: Molecular complexes of nucleosides and nucleotides with a monomeric cationic porphyrin and some of its metal derivatives.
abstract: Tetrakis(4-7V-methylpyridyl)porphine (H2TMpyP) and a number of its metal derivatives interact extensively with
  mononucleotides and mononucleosides in aqueous solution. The complexes formed are of a stacking-type involving extensive
  overlap of the -systems of the porphyrin and purine or pyrimidine bases. Coulombic attractions help stabilize the complexes
  but there is no evidence for ligation of the bases to axial sites of the metalloporphyrins. Stability constants determined via
  NMR and spectrophotometric titrations are larger for purine bases than pyrimidines with a given porphyrin derivative. More
  dramatic influences on stability result from changing porphyrins. Porphyrins having no axial ligands (e.g., metal-free copper(II),
  palladium(II), and nickel(II) derivatives) or one axial ligand (Zn(II)) produce much larger interactions with a given nucleotide
  or nucleoside than do metalloporphyrins having two axial ligands (e.g., Mn(III), Fe(III), or Co(III)). The kinetics of the
  interaction of H2TMpyP with 2'-deoxyadenosine S'-monophosphate (dAMP) were studied via the laser raman temperature-jump
  method. The measured rate constants are consistent with a simple stacking model for the interaction.
authors.forename: R F
authors.initials: RF
authors.lastname: Pasternack
authors.forename: E J
authors.initials: EJ
authors.lastname: Gibbs
authors.forename: A
authors.initials: A
authors.lastname: Gaudemer
authors.forename: A
authors.initials: A
authors.lastname: Antebi
authors.forename: S
authors.initials: S
authors.lastname: Bassner
authors.forename: L
authors.initials: L
authors.lastname: De Poy
authors.forename: D H
authors.initials: DH
authors.lastname: Turner
authors.forename: A
authors.initials: A
authors.lastname: Williams
authors.forename: F
authors.initials: F
authors.lastname: Laplace
authors.forename: M H
authors.initials: MH
authors.lastname: Lansard
authors.forename: C
authors.initials: C
authors.lastname: Merienne
authors.forename: M
authors.initials: M
authors.lastname: Perree-Fauvet
mesh_terms: D002412:Cations / Q000737:chemistry; D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D002412:Cations; D008665:Metalloporphyrins; D009705:Nucleosides; D009711:Nucleotides; D011166:Porphyrins