title: Functional Isoeugenol-Modified Nanogel Coatings for the Design of Biointerfaces.
abstract: A new route for the synthesis of functional aqueous nanogels decorated with a controlled amount of surface-drafted isoeugenol molecules has been developed. Obtained nanogels exhibit two key functions: a) antibacterial activity against different oral pathogens and b) cell-adhesive and -growth-promoting properties. Functional nanogels can be potentially used as building blocks in the design of bioactive coatings on various implants preventing infections and accelerating tissue regeneration.
authors.affiliation: Funktionelle und interaktive Polymere, DWI-Leibniz Institut für Interaktive Materialien, Forckenbeckstrasse 50, 52056, Aachen, Germany.
authors.forename: Michael
authors.identifier: 0000-0001-6139-3483
authors.initials: M
authors.lastname: Kather
authors.affiliation: Lehr- und Forschungsgebiet Orale Mikrobiologie und Immunologie der Klinik für Zahnerhaltung, ZPP, Uniklinik, RWTH Aachen, Germany.
authors.forename: Merle
authors.initials: M
authors.lastname: Skischus
authors.affiliation: Institut für Pathologie und Helmholtz Institut für Biomedizinische Technologien-Zell- und Molekularbiologie an Grenzflächen, Uniklinik, RWTH Aachen, Germany.
authors.forename: Pierre
authors.initials: P
authors.lastname: Kandt
authors.affiliation: Funktionelle und interaktive Polymere, DWI-Leibniz Institut für Interaktive Materialien, Forckenbeckstrasse 50, 52056, Aachen, Germany.
authors.forename: Andrij
authors.initials: A
authors.lastname: Pich
authors.affiliation: Lehr- und Forschungsgebiet Orale Mikrobiologie und Immunologie der Klinik für Zahnerhaltung, ZPP, Uniklinik, RWTH Aachen, Germany.
authors.forename: Georg
authors.identifier: 0000-0003-2577-5294
authors.initials: G
authors.lastname: Conrads
authors.affiliation: Institut für Pathologie und Helmholtz Institut für Biomedizinische Technologien-Zell- und Molekularbiologie an Grenzflächen, Uniklinik, RWTH Aachen, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Neuss
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects; D001424:Bacterial Infections / Q000517:prevention & control; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000517:prevention & control; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D005054:Eugenol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005782:Gels / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009055:Mouth / Q000382:microbiology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D020099:Coated Materials, Biocompatible; D005782:Gels; D005054:Eugenol; D011092:Polyethylene Glycols; C036643:isoeugenol
keywords: antibacterial properties; cell adhesion; gels; isoeugenol; oral pathogens