title: Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata.
abstract: A 21-year-old Bangladesh-born man presented with a month history of evolving neurological symptoms in the context of a six-month history of fever, night sweats, and axillary lymphadenopathy. He was subsequently diagnosed with multiple multidrug resistant intracranial tuberculomata and was successfully treated over two years. Intracranial multidrug resistant tuberculosis has a high mortality and successful treatment is rarely reported. Management is complex and requires consideration of the penetration and likely effect of antituberculous agents within the central nervous system. We discuss the role of various antituberculous agents, the duration of therapy, the utility of corticosteroids, the value of intrathecal and systemic therapy, and the need for rapid diagnosis.
authors.affiliation: Department of Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, Australia; Prince of Wales Clinical School, University of NSW, Sydney, NSW, Australia.
authors.forename: Richard P
authors.identifier: 0000-0001-7176-1673
authors.initials: RP
authors.lastname: Sullivan
authors.affiliation: Department of Respiratory Medicine, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: Hazel F
authors.initials: HF
authors.lastname: Goldberg
authors.affiliation: Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: Ross S
authors.initials: RS
authors.lastname: Mellick
authors.affiliation: Department of Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, Australia; Prince of Wales Clinical School, University of NSW, Sydney, NSW, Australia.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Post