title: Effects of cannabinoid and vanilloid receptor agonists and their interaction on learning and memory in rats.
abstract: Despite previous findings on the effects of cannabinoid and vanilloid systems on learning and memory, the effects of the combined stimulation of these 2 systems on learning and memory have not been studied. Therefore, in this study, we tested the interactive effects of cannabinoid and vanilloid systems on learning and memory in rats by using passive avoidance learning (PAL) tests. Forty male Wistar rats were divided into the following 4 groups: (1) control (DMSO+saline), (2) WIN55,212-2, (3) capsaicin, and (4) WIN55,212-2 + capsaicin. On test day, capsaicin, a vanilloid receptor type 1 (TRPV1) agonist, or WIN55,212-2, a cannabinoid receptor (CB1/CB2) agonist, or both substances were injected intraperitoneally. Compared to the control group, the group treated with capsaicin (TRPV1 agonist) had better scores in the PAL acquisition and retention test, whereas treatment with WIN55,212-2 (CB1/CB2agonist) decreased the test scores. Capsaicin partly reduced the effects of WIN55,212-2 on PAL and memory. We conclude that the acute administration of a TRPV1 agonist improves the rats' cognitive performance in PAL tasks and that a vanilloid-related mechanism may underlie the agonistic effect of WIN55,212-2 on learning and memory.
authors.affiliation: a Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.|b Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mariam
authors.initials: M
authors.lastname: Shiri
authors.affiliation: a Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Komaki
authors.affiliation: b Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Shahrbanoo
authors.initials: S
authors.lastname: Oryan
authors.affiliation: a Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Taheri
authors.affiliation: a Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Komaki
authors.affiliation: a Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Etaee
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D048588:Benzoxazines / Q000008:administration & dosage / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D063386:Cannabinoid Receptor Agonists / Q000494:pharmacology*; D002186:Cannabinoids; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D008568:Memory / Q000187:drug effects*; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D009281:Naphthalenes / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018689:Sensory System Agents / Q000494:pharmacology; D050916:TRPV Cation Channels / Q000819:agonists*
chemical_list: D048588:Benzoxazines; D002121:Calcium Channel Blockers; D063386:Cannabinoid Receptor Agonists; D002186:Cannabinoids; D009025:Morpholines; D009281:Naphthalenes; D018689:Sensory System Agents; D050916:TRPV Cation Channels; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; D002211:Capsaicin
keywords: TRPV1; WIN55,212-2; WIN55,212–2; apprentissage; cannabinoid; cannabinoïde; capsaicin; capsaïcine; learning; memory; mémoire; passive avoidance test; test d’évitement passif; vanilloid; vanilloïde