title: Mechanisms of cell death induction by food-borne mycotoxins.
abstract: Mycotoxins are secondary metabolites of fungi that contaminate a wide range of foods and feeds. Mycotoxin contamination is considered to be an important risk factor for food safety which poses serious threat to human and animal health. Cell death induction is suggested to be the key cellular event contributed to the pleiotropically toxic effects of mycotoxins. During the past decades, substantial progress has been made in uncovering the mechanisms of cell death induction by mycotoxins. Understanding of the mechanisms underlying mycotoxin-induced cytotoxicity will benefit the development of effective strategies for the management of mycotoxin-associated health issues. The current review will discuss the types of cell death induced by mycotoxins and summarize the present understanding of signaling pathways involved in mycotoxin-mediated cytotoxicities.
authors.affiliation: a Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, College of Food Science and Nutritional Engineering , China Agricultural University, National Engineering Research Center for Fruit and Vegetable Processing, Beijing, China , Haidian District, Beijing , China.
authors.forename: Shutao
authors.initials: S
authors.lastname: Yin
authors.affiliation: a Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, College of Food Science and Nutritional Engineering , China Agricultural University, National Engineering Research Center for Fruit and Vegetable Processing, Beijing, China , Haidian District, Beijing , China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Liu
authors.affiliation: b College of Veterinary Medicine , China Agricultural University , Haidian District, Beijing , China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Fan
authors.affiliation: a Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, College of Food Science and Nutritional Engineering , China Agricultural University, National Engineering Research Center for Fruit and Vegetable Processing, Beijing, China , Haidian District, Beijing , China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Hu
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects*; D005506:Food Contamination; D006801:Humans; D009183:Mycotoxins / Q000737:chemistry / Q000633:toxicity*
chemical_list: D009183:Mycotoxins
keywords: MAPKs; Mycotoxins; apoptosis; autophagic cell death; endoplasmic reticulum stress; necrotic cell death; p53; reactive oxygen species