title: Linear accelerator radiosurgery for arteriovenous malformations: Updated literature review.
abstract: Arteriovenous malformations (AVMs) are the leading causing of intra-cerebral haemorrhage. Stereotactic radiosurgery (SRS) is an established treatment for arteriovenous malformations (AVM) and commonly delivered using Gamma Knife within dedicated radiosurgery units. Linear accelerator (LINAC) SRS is increasingly available however debate remains over whether it offers an equivalent outcome. The aim of this project is to evaluate the outcomes using LINAC SRS for AVMs used within a UK neurosciences unit and review the literature to aid decision making across various SRS platforms. Results have shown comparability across platforms and strongly supports that an adapted LINAC based SRS facility within a dynamic regional neuro-oncology department delivers similar outcomes (in terms of obliteration and toxicity) to any other dedicated radio-surgical platform. Locally available facilities can facilitate discussion between options however throughput will inevitably be lower than centrally based dedicated national radiosurgery units.
authors.affiliation: Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Yahya
authors.affiliation: Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Heyes
authors.affiliation: Wolfson Computer Laboratory, University Hospitals Birmingham, NHS Foundation Trust, United Kingdom.
authors.forename: P
authors.initials: P
authors.lastname: Nightingale
authors.affiliation: Department of Neuroradiology, University Hospitals Birmingham, NHS Foundation Trust, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Lamin
authors.affiliation: Department of Neuroradiology, University Hospitals Birmingham, NHS Foundation Trust, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Chavda
authors.affiliation: Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: I
authors.initials: I
authors.lastname: Geh
authors.affiliation: Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Spooner
authors.affiliation: Department of Neurosurgery, University Hospitals Birmingham, NHS foundation Trust, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Cruickshank
authors.affiliation: Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital, Birmingham, United Kingdom. Electronic address: paul.sanghera@uhb.nhs.uk.
authors.forename: P
authors.initials: P
authors.lastname: Sanghera
mesh_terms: D000328:Adult; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators / Q000706:statistics & numerical data; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Arteriovenous malformation; Linac based; Stereotactic radiotherapy