title: Early Prognostic Value of Monitoring Serum Free Light Chain in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.
abstract: We hypothesized the levels of free light chains obtained before and after autologous stem cell transplantation can be useful in predicting transplantation outcome. We analyzed 70 multiple myeloma patients. Abnormal free light chain ratios before stem cell transplantation were found to be associated early progression, although without any impact on overall survival. At day +30, the normalization of levels of involved free light chain related with early progression. According to these results almost one-third reduction of free light chain levels can predict favorable prognosis after autologous stem cell transplantation.
authors.affiliation: a Department of Hematology , Gazi University School of Medicine , Ankara , Turkey.
authors.forename: Zübeyde Nur
authors.initials: ZN
authors.lastname: Özkurt
authors.affiliation: a Department of Hematology , Gazi University School of Medicine , Ankara , Turkey.
authors.forename: Gülsan Türköz
authors.initials: GT
authors.lastname: Sucak
authors.affiliation: a Department of Hematology , Gazi University School of Medicine , Ankara , Turkey.
authors.forename: Şahika Zeynep
authors.initials: ŞZ
authors.lastname: Akı
authors.affiliation: a Department of Hematology , Gazi University School of Medicine , Ankara , Turkey.
authors.forename: Münci
authors.initials: M
authors.lastname: Yağcı
authors.affiliation: a Department of Hematology , Gazi University School of Medicine , Ankara , Turkey.
authors.forename: Rauf
authors.initials: R
authors.lastname: Haznedar
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D003131:Combined Modality Therapy; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D007147:Immunoglobulin Light Chains
keywords: Autologous stem cell transplantation; Free light chain; Multiple myeloma; Prognosis; Progression free survival