title: Prevalence and correlates of DSM-5 major depressive and related disorders in the community.
abstract: Although the DSM-5 has suggested the two new categories of Persistent Depressive Disorders (PDD) and Other Specified Depressive Disorders (OSDD), no study so far has applied the DSM-5 criteria throughout the range of depressive disorders. The aims of the present study were to 1) establish the lifetime prevalence of specific depressive disorders according to the new DSM-5 definitions in a community sample, and 2) determine their clinical relevance in terms of socio-demographic characteristics, comorbidity, course and treatment patterns. The semi-structured Diagnostic Interview for Genetic Studies was administered by masters-level psychologists to a random sample of an urban area (n=3720). The lifetime prevalence was 15.2% for PDD with persistent major depressive episode (MDE), 3.3% for PDD with pure dysthymia, 28.2% for Major Depressive Disorder (MDD) and 9.1% for OSDD. Subjects with PDD with persistent MDE were the most severely affected, followed by those with recurrent MDD, single episode MDD, PDD with pure dysthymia and OSDD and finally those without depressive disorders. Our data provide further evidence for the clinical significance of mild depressive disorders (OSDD), but cast doubt on the pertinence of lumping together PDD with persistent MDE and the former DSM-IV dysthymic disorder within the new PDD category.
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland. Electronic address: Caroline.Vandeleur@chuv.ch.
authors.forename: Caroline L
authors.initials: CL
authors.lastname: Vandeleur
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Sylfa
authors.initials: S
authors.lastname: Fassassi
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Enrique
authors.initials: E
authors.lastname: Castelao
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland; Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Glaus
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Marie-Pierre F
authors.initials: MF
authors.lastname: Strippoli
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Aurélie M
authors.initials: AM
authors.lastname: Lasserre
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Dominique
authors.initials: D
authors.lastname: Rudaz
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Sirak
authors.initials: S
authors.lastname: Gebreab
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pistis
authors.affiliation: Department of Mental Health and Psychiatry, University Hospital of Geneva, Switzerland.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Aubry
authors.affiliation: Zurich University Psychiatric Hospital, Switzerland.
authors.forename: Jules
authors.initials: J
authors.lastname: Angst
authors.affiliation: Department of Psychiatry, University Hospital of Lausanne, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Preisig
mesh_terms: D000328:Adult; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D019263:Dysthymic Disorder / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence
keywords: Comorbidity; Course; Major depression; Persistent depression; Prevalence; Subthreshold depression; Treatment