title: Bispecific Antibodies (bsAbs): Promising Immunotherapeutic Agents for Cancer Therapy.
abstract: Antibodies have become the preferred therapeutic treatment option for cancers. Antibody therapy is associated with low toxic profile and specific in its activity, unlike chemotherapy and radiotherapy. Types of tumor are known to express multiple receptors that cross-talk to activate perpetual growth, proliferation and metastasis, and inhibit apoptosis in such tumors. Bispecific antibodies (BsAbs) are therefore the preferred agent for the treatment of such cancers due to its unique characteristics. This review discusses up to date therapeutic potentials of BsAbs.
authors.affiliation: Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast. Ghana.
authors.forename: Deasmond O
authors.initials: DO
authors.lastname: Acheampong
authors.affiliation: Department of Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast. Ghana.
authors.forename: Christian K
authors.initials: CK
authors.lastname: Adokoh
authors.affiliation: Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast. Ghana.
authors.forename: Paulina
authors.initials: P
authors.lastname: Ampomah
authors.affiliation: Department of Molecular Biology and Biotechnology, School of Biological Sciences, University of Cape Coast, Cape Coast. Ghana.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Agyirifor
authors.affiliation: Department of Medical Laboratory Technology, School of Allied Health Sciences, University of Cape Coast, Cape Coast. Ghana.
authors.forename: Isaac
authors.initials: I
authors.lastname: Dadzie
authors.affiliation: Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast. Ghana.
authors.forename: Francis A
authors.initials: FA
authors.lastname: Ackah
authors.affiliation: Department of Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast. Ghana.
authors.forename: Ernest A
authors.initials: EA
authors.lastname: Asiamah
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000737:chemistry / Q000235:genetics / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D009369:Neoplasms / Q000628:therapy*
chemical_list: D018033:Antibodies, Bispecific
keywords: Antibody; antitumor; bispecific antibody (BsAb); cancer therapy; diabody; immunotherapeutic agent