title: Lead adsorption, anticoagulation and in vivo toxicity studies on the new magnetic nanomaterial Fe3O4@SiO2@DMSA as a hemoperfusion adsorbent.
abstract: This project aimed to develop and characterize a new nanoadsorbent for hemoperfusion. Fe3O4nanoparticles synthesized by a facile solvothermal method were coated with SiO2and further modified by DMSA. TEM, XRD, FTIR, XPS and SEM were performed before and after lead adsorption to reveal the general performance and adsorption mechanism. Rabbit lead poisoning models were established to study the adsorption rate; then, a pig hemoperfusion experiment was used for further validation. In addition, coagulation, liver, kidney and heart function, blood lipids, electrolytes and the immune inflammatory system were studied before and after hemoperfusion. The results indicated that the materials had a high adsorption rate and chemisorbed lead mainly in the plasma. No obvious coagulation-fibrinolysis, organ toxicity, electrolyte disturbances, inflammatory reactions or immunosuppression was observed. The excellent blood compatibility and high biosafety of this material demonstrate its potential as a new type of hemoperfusion adsorbent.
authors.affiliation: Urology Surgery of Haikou People's Hospital, Haikou, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Urology Surgery of Haikou People's Hospital, Haikou, China. Electronic address: HKBZM59@aliyun.com.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Bai
authors.affiliation: Central Laboratory of Haikou People's Hospital, Haikou, China.
authors.forename: Shufang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Hemodialysis Department of Haikou People's Hospital, Haikou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Central Laboratory of Haikou People's Hospital, Haikou, China.
authors.forename: Shunlan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Clinical Laboratory of Haikou People's Hospital, Haikou, China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wei
authors.affiliation: Hemodialysis Department of Haikou People's Hospital, Haikou, China.
authors.forename: Wenshi
authors.initials: W
authors.lastname: Mo
authors.affiliation: Urology Surgery of Haikou People's Hospital, Haikou, China.
authors.forename: Jiale
authors.initials: J
authors.lastname: Long
authors.affiliation: Urology Surgery of Haikou People's Hospital, Haikou, China.
authors.forename: Zhenxiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Animal Operation Center of Haikou People's Hospital, Haikou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Central Laboratory of Haikou People's Hospital, Haikou, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Zheng
authors.affiliation: School of Metallurgy and Environment, Central South University, Changsha, China.
authors.forename: Xueyi
authors.initials: X
authors.lastname: Guo
authors.affiliation: School of Metallurgy and Environment, Central South University, Changsha, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Xiaoyang
authors.affiliation: School of Metallurgy and Environment, Central South University, Changsha, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Mao
authors.affiliation: Department of Pharmaceutical Science, Ningxia Medical University, Yinchuan, China.
authors.forename: Ningchuan
authors.initials: N
authors.lastname: Feng
mesh_terms: D000327:Adsorption; D000818:Animals; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006464:Hemoperfusion; D007854:Lead / Q000737:chemistry*; D007855:Lead Poisoning / Q000628:therapy*; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D011817:Rabbits; D012822:Silicon Dioxide / Q000737:chemistry; D004113:Succimer / Q000737:chemistry; D013552:Swine; D018675:Toxicity Tests
chemical_list: D007854:Lead; D012822:Silicon Dioxide; D004113:Succimer; D052203:Ferrosoferric Oxide
keywords: Adsorption mechanism; Biosafety; Fe(3)O(4)@SiO(2)@DMSA nanoparticle; Hemoperfusion; Pigs