title: Downhill exercise training in monocrotaline-injected rats: Effects on echocardiographic and haemodynamic variables and survival.
abstract: BACKGROUND
  Eccentric exercise training has been shown to improve muscle force strength without excessive cardiovascular stress. Such an exercise modality deserves to be tested in pulmonary arterial hypertension.
  
  
  OBJECTIVE
  We aimed to assess the effects of an eccentric training modality on cardiac function and survival in an experimental monocrotaline-induced model of pulmonary arterial hypertension with right ventricular dysfunction.
  
  
  METHODS
  Forty rats were randomly assigned to one of four groups: 40mg/kg monocrotaline-injected sedentary rats; 40mg/kg monocrotaline-injected eccentric-trained rats; sedentary control rats; or eccentric-trained control rats. Eccentric exercise training consisted of downhill running on a treadmill with a -15° slope for 30minutes, 5 days a week for 4 weeks. Training tolerance was assessed by echocardiography, right ventricle catheterization and the rats' maximal eccentric speed.
  
  
  RESULTS
  Survival in monocrotaline-injected eccentric-trained rats was not different from that in monocrotaline-injected sedentary rats. Monocrotaline-injected eccentric-trained rats tolerated this training modality well, and haemodynamic status did not deteriorate further compared with monocrotaline-injected sedentary rats. The eccentric maximal speed decline was less pronounced in trained compared with sedentary pulmonary arterial hypertension rats.
  
  
  CONCLUSIONS
  Eccentric exercise training had no detrimental effects on right heart pressure, cardiac function and survival in rats with stable monocrotaline-induced pulmonary hypertension.
authors.affiliation: Service de physiologie et d'explorations fonctionnelles, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, 67091 Strasbourg, France; Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France. Electronic address: Irina.Enache@chru-strasbourg.fr.
authors.forename: Irina
authors.initials: I
authors.lastname: Enache
authors.affiliation: Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Favret
authors.affiliation: Service de physiologie et d'explorations fonctionnelles, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, 67091 Strasbourg, France; Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Doutreleau
authors.affiliation: Service de physiologie et d'explorations fonctionnelles, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, 67091 Strasbourg, France; Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Paola
authors.initials: P
authors.lastname: Goette Di Marco
authors.affiliation: Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Charles
authors.affiliation: Service de physiologie et d'explorations fonctionnelles, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, 67091 Strasbourg, France; Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Geny
authors.affiliation: Service de physiologie et d'explorations fonctionnelles, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, 67091 Strasbourg, France; Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Charloux
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D004195:Disease Models, Animal; D004452:Echocardiography; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D016686:Monocrotaline / Q000633:toxicity*; D010805:Physical Conditioning, Animal / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016686:Monocrotaline
keywords: Dysfonction ventriculaire droite; Eccentric exercise; Echocardiography; Entraînement; Exercice excentrique; Hypertension pulmonaire; Monocrotaline; Pulmonary hypertension; Right ventricular dysfunction; Training; Échocardiographie