title: TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer.
abstract: Breast cancer remains a lethal disease to women due to lymph node metastasis, the tumor microenvironment, secondary resistance and other unknown factors. Several important transcription factors involved in this disease, such as PTEN, p53 and beta-catenin, have been identified and researched in-depth as candidates for targeted therapy in breast cancer. TFDP3 is a new, promising candidate for transcriptional regulation in breast cancer, although it was first identified in hepatocellular carcinoma. Here, we demonstrate that TFDP3 is expressed in a variety of malignancies, normal testis tissue and breast cancer cell lines and thus provide evidence that TFDP3 is a cancer-testis antigen. We illustrate that overexpression or silencing TFDP3 interferes with epithelial-mesenchymal transition but does not influence cell proliferation, indicating that the TFDP3 protein acts as a transcription factor during epithelial-mesenchymal transition. These data highlight that TFDP3 is expressed in breast cancer, that it is a member of the cancer-testis antigen family and that it functions as a regulator in epithelial-mesenchymal transition.
authors.affiliation: Department of Immunology, School of Basic Medical Science, Peking University, Beijing, China.
authors.forename: Kailin
authors.initials: K
authors.lastname: Yin
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning, China.
authors.forename: Yanchen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Immunology, School of Basic Medical Science, Peking University, Beijing, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chu
authors.affiliation: Department of Immunology, School of Basic Medical Science, Peking University, Beijing, China.
authors.forename: Yuedan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D013737:Testis / Q000378:metabolism; D050680:Transcription Factor DP1 / Q000378:metabolism / Q000502:physiology*; D059016:Tumor Microenvironment
chemical_list: C516920:TFDP3 protein, human; D050680:Transcription Factor DP1