title: Recent Advances in Nonlinear Optical Analyses of Pharmaceutical Materials in the Solid State.
abstract: The past decade has seen an increase in the use of nonlinear optical (NLO) techniques such as second harmonic generation, coherent antistokes Raman scattering, stimulated Raman scattering, and two-photon fluorescence for the solid-state characterization of pharmaceutical materials. These combined techniques offer several advantages (e.g., speed, selectivity, quantitation) of potential interest to the pharmaceutical community, as decreased characterization times in formulation development and testing could help decrease the time required to bring new, higher quality drugs to market. The large body of literature recently published in this field merits a review. Literature will be discussed in order of drug development, starting with applications in initial therapeutic molecule crystallization and polymorphic analysis, followed by final dosage form characterization, and ending with drug product performance testing.
authors.affiliation: Department of Chemistry, Wabash College , Crawfordsville, Indiana 47933, United States.
authors.forename: Paul D
authors.identifier: 0000-0002-1460-5559
authors.initials: PD
authors.lastname: Schmitt
mesh_terms: D004304:Dosage Forms; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations
keywords: amorphous solid dispersions; chemical imaging; coherent antistokes Raman spectroscopy; dissolution testing; formulation development; nonlinear optics; pharmaceuticals; polymorphism; second harmonic generation; stimulated Raman spectroscopy