title: Dark Adaptation in Patients with Primary Open-Angle Glaucoma, Pseudoexfoliation Glaucoma and Childhood Glaucoma.
abstract: PurposeTo investigate the state of dark adaptation and macular blood flow in different forms of glaucoma.MethodsEighteen eyes of 18 patients with primary open-angle glaucoma, 14 eyes of 14 patients with pseudoexfoliation glaucoma, and 10 eyes of 10 patients with childhood glaucoma (CG) were examined by means of dark adaptometry, scanning-laser retinal flowmetry, and retinal tomography.ResultsAll glaucomatous eyes had comparable optic disc excavation (one-way ANOVA, p = 0.138). Eyes with CG had significantly lower best-corrected visual acuity than the other groups (Tukey, all p < 0.0001). Macular perfusion was comparable in all three groups (one - way ANOVA, p = 0.08). The delay in rod-cone break time in the CG group was significantly higher than in the other groups (Tukey, all p < 0.0001). The scotopic sensitivity threshold in the CG group was significantly greater than in the other groups (Tukey, all p < 0.01).ConclusionThis underlying dysfunction of dark adaptation may contribute, at least to some extent, to the decreased visual perception observed in patients with CG.
authors.affiliation: Department of Ophthalmology, Ipswich Hospital NHS Trust, University of Cambridge, Ipswich, UK (Lead: Mr C. Edelsten).
authors.forename: G D
authors.initials: GD
authors.lastname: Panos
authors.affiliation: Department of Ophthalmology, University of Athens, Greece (Head: Pr I. Ladas).
authors.forename: M M
authors.initials: MM
authors.lastname: Moschos
authors.affiliation: Paediatric Ophthalmology Unit, Ophthalmica Eye Institute, Thessaloniki, Greece (Head of the Unit: Dr N. Kozeis).
authors.forename: N
authors.initials: N
authors.lastname: Kozeis
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom (Lead. Declan Flanagan).
authors.forename: R R
authors.initials: RR
authors.lastname: Deshmukh
authors.affiliation: Clinique Montchoisi, Lausanne, Switzerland (Head Pr. A. Mermoud).
authors.forename: K
authors.initials: K
authors.lastname: Mansouri
authors.affiliation: Department of Ophthalmology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland (Head Prof. G. Thumann).
authors.forename: T
authors.initials: T
authors.lastname: Shaarawy
authors.affiliation: Paediatric Ophthalmology Unit, Ophthalmica Eye Institute, Thessaloniki, Greece (Head of the Unit: Dr N. Kozeis).
authors.forename: Z
authors.initials: Z
authors.lastname: Gatzioufas
mesh_terms: D003623:Dark Adaptation; D017889:Exfoliation Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields