title: The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.
abstract: Metabolic diseases are associated with an increased risk of developing cardiovascular disease. The features comprising metabolic diseases include obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hypertension. Recent evidence has emerged showcasing a role for cytochrome P450 epoxygenases, soluble epoxide hydrolase, and epoxyeicosatrienoic acids (EETs) in the development and progression of metabolic diseases. This review discusses the current knowledge related to the modulation of cytochrome P450 epoxygenases and soluble epoxide hydrolase to alter concentrations of biologically active EETs, resulting in effects on insulin resistance, lipid metabolism, obesity, and diabetes. Future areas of research to address current deficiencies in the understanding of these enzymes and their eicosanoid metabolites in various aspects of metabolic diseases are also discussed.
authors.affiliation: Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China; and.
authors.forename: Xizhen
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China; and.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China; and.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Chen
authors.affiliation: Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Hoopes
authors.affiliation: Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC.
authors.forename: Darryl C
authors.initials: DC
authors.lastname: Zeldin
authors.affiliation: Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China; and dwwang@tjh.tjmu.edu.cn.
authors.forename: Dao Wen
authors.initials: DW
authors.lastname: Wang
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D015777:Eicosanoids / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D015777:Eicosanoids; D003577:Cytochrome P-450 Enzyme System; D004851:Epoxide Hydrolases
keywords: cytochrome P450 (CYP) epoxygenase; epoxyeicosatrienoic acid; insulin resistance; lipid; obesity; soluble epoxide hydrolase; type 2 diabetes