title: [Reactive arthritis due to Clostridium difficile: Report of two cases and literature review].
abstract: BACKGROUND
  Reactive arthritis due to Clostridium difficile infection is uncommon.
  
  
  METHODS
  We report two cases of reactive arthritis associated with C. difficile infection that occurred in a 40-year-old woman and a 47-year-old man. The literature review between 1976 (date of first reported case) and 2016 retrieved 54 observations (including our two cases). Reactive arthritis occurs most frequently in young subjects after a variable time frame according to C. difficile infection, involving one or several articulations. The issue is generally favourable with or without anti-inflammatory treatment.
  
  
  CONCLUSIONS
  The increasing incidence of C. difficile infection makes more likely the occurrence of this related reactive arthritis. Therefore physicians should consider it in differential diagnosis of bacterial infections capable of causing reactive arthritis.
authors.affiliation: Service de médecine interne, institut hospitalier Franco-Britannique, 92300 Levallois-Perret, France. Electronic address: philippe.garrigues@ihfb.org.
authors.forename: P
authors.initials: P
authors.lastname: Garrigues
authors.affiliation: Service de médecine interne, institut hospitalier Franco-Britannique, 92300 Levallois-Perret, France.
authors.forename: T
authors.initials: T
authors.lastname: de Roux
authors.affiliation: Service de médecine interne, institut hospitalier Franco-Britannique, 92300 Levallois-Perret, France.
authors.forename: E
authors.initials: E
authors.lastname: Georgilopoulos
authors.affiliation: Service de médecine interne, institut hospitalier Franco-Britannique, 92300 Levallois-Perret, France.
authors.forename: E
authors.initials: E
authors.lastname: Wanono
authors.affiliation: Service de médecine interne, institut hospitalier Franco-Britannique, 92300 Levallois-Perret, France.
authors.forename: A
authors.initials: A
authors.lastname: Mathieu
mesh_terms: D000328:Adult; D016918:Arthritis, Reactive / Q000175:diagnosis / Q000382:microbiology*; D016360:Clostridioides difficile / Q000302:isolation & purification / Q000502:physiology*; D003015:Clostridium Infections / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Arthrite réactionnelle; Clostridium difficile; Reactive arthritis