title: Comparison of the Effects of Intrathecal Fentanyl and Intrathecal Morphine on Pain in Elective Total Knee Replacement Surgery.
abstract: Objective. Total knee replacement is one of the most painful orthopedic surgical procedures. In this study, our goal was to compare the intraoperative and postoperative hemodynamic effects, the side effects, the effect on the duration of pain start, the 24-hour VAS, and the amount of additional analgesia used, of the fentanyl and morphine we added to the local anesthetic in the spinal anesthesia we administered in cases of elective knee replacement.Materials and Methods. After obtaining the approval of the Erciyes University Medical Faculty Clinical Drug Trials Ethics Committee, as well as the verbal and written consent of the patients, we included 50 patients in our prospective, randomized study.Results. In our study, the morphine group (Group M) had lower pain scores in the 2nd, 6th, 12th, and 24th hours compared to the fentanyl group (Group F). When additional analgesic requirements were compared, it was found that in the 2nd, 6th, and 24th hours fewer Group M patients needed more analgesics than did Group F patients.Conclusion. The fentanyl group also had lower first analgesic requirement times than did the morphine group. In terms of nausea and vomiting, there was no statistically significant difference between the two groups.
authors.affiliation: Anesthesiology and Reanimation Clinic, Bor State Hospital, Niğde, Turkey.
authors.forename: Refika
authors.initials: R
authors.lastname: Kılıçkaya
authors.affiliation: Anesthesiology and Reanimation Clinic, Mardin State Hospital, Mardin, Turkey.
authors.forename: Yavuz
authors.identifier: 0000-0002-8356-6223
authors.initials: Y
authors.lastname: Orak
authors.affiliation: Anesthesiology and Reanimation Clinic, Bor State Hospital, Niğde, Turkey.
authors.forename: Mehtap Arda
authors.initials: MA
authors.lastname: Balcı
authors.affiliation: Anesthesiology and Reanimation Clinic, Niğde State Hospital, Niğde, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Balcı
authors.affiliation: Medical Biostatistics Department, Çukurova University, Adana, Turkey.
authors.forename: İlker
authors.identifier: 0000-0002-9485-3295
authors.initials: İ
authors.lastname: Ünal
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D017558:Elective Surgical Procedures / Q000009:adverse effects*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D009020:Morphine / Q000008:administration & dosage*; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; D005283:Fentanyl