title: Identifying and targeting cancer stem cells in the treatment of gastric cancer.
abstract: Current treatment regimens for gastric cancer are not adequate. Cancer stem cells (CSCs) may be a key driving factor for growth and metastasis of this tumor type. In contrast to the conventional clonal evolution hypothesis, CSCs can initiate tumor formation, self-renew, and differentiate into tumor-propagating cells. Because gastric cancer can originate from CSCs, it is necessary to review current targets of signaling pathways for CSCs in gastric cancer that are being studied in clinical trials. These pathways are known to regulate the self-renewal and differentiation process in gastric CSCs. A better understanding of the clinical results of trials that target gastric CSCs will lead to better outcomes for patients with gastric cancer. Cancer 2017;123:1303-1312. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
authors.affiliation: Gastrointestinal Cancer Program, Mayo Clinic Cancer Center, Phoenix, Arizona.|Division of Hematology and Oncology, Mayo Clinic, Phoenix, Arizona.
authors.forename: Tanios
authors.initials: T
authors.lastname: Bekaii-Saab
authors.affiliation: Department of Hematology and Medical Oncology, Emory School of Medicine, Atlanta, Georgia.
authors.forename: Bassel
authors.initials: B
authors.lastname: El-Rayes
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014408:Biomarkers, Tumor; D002986:Clinical Trials as Topic; D019468:Disease Management; D055808:Drug Discovery; D006801:Humans; D058990:Molecular Targeted Therapy; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: cancer stem cells; clinical trials; gastric cancer; napabucasin; targeted therapy; vismodeqib