title: Epithelial cell migration as a potential therapeutic target in early lung cancer.
abstract: Lung cancer is the most lethal cancer type worldwide, with the majority of patients presenting with advanced stage disease. Targeting early stage disease pathogenesis would allow dramatic improvements in lung cancer patient survival. Recently, cell migration has been shown to be an integral process in early lung cancer ontogeny, with preinvasive lung cancer cells shown to migrate across normal epithelium prior to developing into invasive disease. TP53 mutations are the most abundant mutations in human nonsmall cell lung cancers and have been shown to increase cell migration via regulation of Rho-GTPase protein activity. In this review, we explore the possibility of targeting TP53-mediated Rho-GTPase activity in early lung cancer and the opportunities for translating this preclinical research into effective therapies for early stage lung cancer patients.
authors.affiliation: Lungs for Living, UCL Respiratory, Division of Medicine, University College London, London, UK.|Dept of Thoracic Medicine, University College London Hospital, London, UK.
authors.forename: Fraser R
authors.initials: FR
authors.lastname: Millar
authors.affiliation: Lungs for Living, UCL Respiratory, Division of Medicine, University College London, London, UK.|Dept of Thoracic Medicine, University College London Hospital, London, UK.
authors.forename: Sam M
authors.initials: SM
authors.lastname: Janes
authors.affiliation: Lungs for Living, UCL Respiratory, Division of Medicine, University College London, London, UK Adam.Giangreco@ucl.ac.uk.
authors.forename: Adam
authors.initials: A
authors.lastname: Giangreco
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement / Q000187:drug effects*; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D058990:Molecular Targeted Therapy; D009154:Mutation; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D015398:Signal Transduction / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D020741:rho GTP-Binding Proteins