title: [Radical Resection of cT3a Gallbladder Cancer after Neoadjuvant Chemotherapy - A Case Report].
abstract: We report a case of a radical resection of cT3a gallbladder cancer after neoadjuvant chemotherapy(NAC). A 68-year-old man was referred to our hospital with a chief complaint of right hypochondralgia.Imaging findings were consistent with acute cholecystitis with a stone at the neck of the gallbladder, and advanced gallbladder cancer with infiltration into segments 4 and 5 from the fundus of the gallbladder, Gfb, cT3a(liver), cN1(8a), cM0, cStage III B, was diagnosed on staging laparoscopy. The patient received 3 courses of GEM plus CDDP NAC.The response to the treatment included reduction of the main tumor by 35%, diminished accumulation of FDG at the 8a lymph node, and decrease in serum CA19-9, from 163 U/mL to 75 U/mL. Cholecystectomy with the gallbladder bed and regional lymphadenectomy were performed.The histologic examination revealed extensive necrosis and degeneration of cancer cells in the infiltrating lesions, and the therapeutic effect was judged as Grade I b.The patient has now survived for 11 months without recurrence.
authors.affiliation: Dept. of General and Digestive Surgery, Kanazawa Medical University.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Ueda
authors.forename: Yoritaka
authors.initials: Y
authors.lastname: Fujii
authors.forename: Seiko
authors.initials: S
authors.lastname: Miura
authors.forename: Jun
authors.initials: J
authors.lastname: Fujita
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kaida
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Tomita
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funaki
authors.forename: Hideto
authors.initials: H
authors.lastname: Fujita
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kinami
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nakano
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D041881:Cholecystitis, Acute / Q000209:etiology / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine