title: Lessons from the genomes and transcriptomes of filarial nematodes.
abstract: Human filarial infections are a leading cause of morbidity in the developing world. While a small arsenal of drugs exists to treat these infections, there remains a tremendous need for the development of additional interventions. Recent genome sequences and transcriptome analyses of filarial nematodes have provided novel biological insight and allowed for the prediction of novel drug targets as well as potential vaccine candidates. In this review, we discuss the currently available data, insights gained into the metabolism of these organisms, and how the filaria field can move forward by leveraging these data.
authors.affiliation: Center for Genomics and Systems Biology, Department of Biology, New York University, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Grote
authors.affiliation: Molecular Parasitology, New York Blood Center, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Lustigman
authors.affiliation: Center for Genomics and Systems Biology, Department of Biology, New York University, USA. Electronic address: elodie.ghedin@nyu.edu.
authors.forename: Elodie
authors.initials: E
authors.lastname: Ghedin
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000639:trends; D005370:Filarioidea / Q000235:genetics*; D056726:Genetic Association Studies / Q000639:trends; D049751:Genome, Helminth; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D059467:Transcriptome
keywords: Filaria; Genomics; Parasitic nematodes; Transcriptomics