title: [Pathological Complete Response Obtained by Eribulin Chemotherapy in a Case of Advanced Breast Cancer].
abstract: A goal for treating advanced disease is prolonging survival while maintaining a good quality of life(QOL). Eribulin chemotherapy may be suitable for this purpose. We report a case of advanced breast cancer with pathological complete response (pCR)obtained by eribulin chemotherapy. The patient was a 43-year-old woman who complained of a right mammary mass. A tumor measuring approximately 3 cm was palpated, and breast cancer was detected via ultrasound examination. Core needle biopsy indicated invasive ductal carcinoma based on histopathological findings. A metastasis to the supraclavicular lymph node was observed and was found to be malignant via fine-needle aspiration cytology. The patient was diagnosed with advanced breast cancer cT2N3M0, stage III C, Luminal B like. She underwent primary systemic therapy with 6 cycles of eribulin. The patient exhibited a clinical complete response to eribulin chemotherapy. Thereafter, a right mastectomy with level 3 axillary lymph node dissection was performed. Pathological diagnosis of the surgical specimen was pCR. At present, 3 years after surgery, the patient has no recurrence.
authors.affiliation: Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Asano
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kashiwagi
authors.forename: Wataru
authors.initials: W
authors.lastname: Goto
authors.forename: Koji
authors.initials: K
authors.lastname: Takada
authors.forename: Tamami
authors.initials: T
authors.lastname: Morisaki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takashima
authors.forename: Satoru
authors.initials: S
authors.lastname: Noda
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Onoda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ohira
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006801:Humans; D007659:Ketones / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D020360:Neoadjuvant Therapy; D000095662:Polyether Polyketides
chemical_list: D005663:Furans; D007659:Ketones; C490954:eribulin; D000095662:Polyether Polyketides