title: Cordycepin inhibits airway remodeling in a rat model of chronic asthma.
abstract: The potential suppression role of cordycepin (Cor) on airway remodeling in a rat model of chronic asthma was investigated in this paper. We evaluated the anti-remodeling of Cor (50mg/kg) combined with or without budesonide (BUD) and investigated the possible underlying molecular mechanisms. We found that Cor attenuated immunoglobulin (Ig) E, alleviated the airway wall thickness, and decreased eosinophils and neutrophils in the bronchoalveolar lavage fluid (BALF). Notably, Cor reduced the up-regulation of IL-5, IL-13 and TNF-α in the BALF. Cor also regulated the increase of A2AARmRNA and the decrease of TGF-β1expression. Furthermore, Cor markedly blocked p38MAPK signaling pathway activation in the OVA-driven asthmatic mice. The combination treatment of Cor and BUD showed profound efficacy in regulating the levels of inflammatory cells and the expression of IL-13, TGF-β1and A2AARmRNA. Collectively, this study demonstrated that Cor combined with glucocorticoids treatment shows synergistically profound efficacy in inhibiting airway remodeling, and some benefits of Cor may result from the increased A2AARmRNA expression, the reduced TGF-β1levels and the inhibition of Th2-cytokines through the suppression of the p38MAPK signaling pathways.
authors.affiliation: Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Fei
authors.affiliation: Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China.
authors.forename: Wu-Ping
authors.initials: WP
authors.lastname: Bao
authors.affiliation: Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China. Electronic address: maggie_zhangmin@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China. Electronic address: xzhou53@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
mesh_terms: D056151:Airway Remodeling / Q000187:drug effects*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D001980:Bronchi / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D019819:Budesonide / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D003839:Deoxyadenosines / Q000627:therapeutic use*; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D007958:Leukocyte Count; D010047:Ovalbumin; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors
chemical_list: D018927:Anti-Asthmatic Agents; D016207:Cytokines; D003839:Deoxyadenosines; D007074:Immunoglobulin G; D018836:Inflammation Mediators; D019819:Budesonide; D010047:Ovalbumin; D048051:p38 Mitogen-Activated Protein Kinases; C058120:cordycepin
keywords: Airway remodeling; Asthma; Cordycepin