title: Hyperthyroidism-associated hypercalcemic crisis: A case report and review of the literature.
abstract: BACKGROUND
  Hyperthyroidism is one of the major clinical causes of hypercalcaemia, however, hyperthyroidism-related hypercalcemic crisis is rare, only 1 case have been reported. The potential mechanisms are still not too clear. It may be related that thyroid hormone stimulate bone turnover, elevate serum calcium, increase urinary and fecal calcium excretion.
  
  
  METHODS
  A 58-year-old female patient was found to have Graves' disease, a marked elevated serum calcium level (adjusted serum calcium: 3.74 mmol/L), and reduced parathyroid hormone level.
  
  
  METHODS
  She was diagnosed as hyperthyroidism-associated hypercalcemic crisis.
  
  
  METHODS
  Treatment with methimazole to correct the hyperthyroidism and treatment of the patient's hypercalcaemia was achieved by physiological saline, salmon calcitonin and furosemide.
  
  
  RESULTS
  After treatment for hypercalcaemia and hyperthyroidism, her symptoms and serum calcium levels quickly returned to normal.
  
  
  CONCLUSIONS
  hyperthyroid-associated hypercalcaemia crisis is rare, however, the diagnosis should pay attention to screening for other diseases caused by hypercalcemia. Timely treatment of hypercalcaemia is a critical step for rapidly control of symptoms, and treatment of hyperthyroidism is beneficial to relief the symptoms and maintain the blood calcium level.
authors.affiliation: Department of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Xie
authors.forename: Liling
authors.initials: L
authors.lastname: Zhao
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Mo
mesh_terms: D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008875:Middle Aged