title: Umbilical cord-derived mesenchymal stem cell transplantation for treating elderly vascular dementia.
abstract: This study aimed to determine the efficacy and safety of human umbilical cord-derived mesenchymal stem cell (HUC-MSC) transplantation for treating elderly vascular dementia (VaD). Ten VaD patients (average age, 73.88 years old) were treated. HUC-MSCs were isolated, cultured, stem cell-marked, and qualified and administered as a 3-course intravenous infusion to these patients. The Mini-Mental State Exam (MMSE) and the Activities of Daily Living Index (Barthel Index scoring system) were used to assess the cognitive function and daily living activity improvements in these patients before transplantation (T0), 3 months after transplantation (T1), and 6 months after transplantation (T2). The MMSE and Barthel Index scores were 15.80 ± 5.49 and 42.00 ± 9.33 points at T0, respectively, and were significantly different when compared with those at T1 (19.20 ± 6.39 and 49.20 ± 10.86 points, respectively, P < 0.05), whereas there was no difference when compared with those at T2 (14.00 ± 6.55 and 40.70 ± 10.37 points, respectively, P > 0.05). HUC-MSC transplantation was safe and feasible for VaD and improved early cognitive functions and daily living activities in VaD patients to a certain extent, thus improving patients' quality of life.
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China. xingfangjin@126.com.
authors.forename: Xingfang
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Central Laboratory, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Mingyao
authors.initials: M
authors.lastname: Meng
authors.affiliation: Department of Central Laboratory, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Zongliu
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Geriatric, the Second People's Hospital of Kunming, Kunming, 650203, China.
authors.forename: Weimeng
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of Geriatric, the Second People's Hospital of Kunming, Kunming, 650203, China.
authors.forename: You
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Central Laboratory, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Wenju
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Yunhong
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Hongqiong
authors.initials: H
authors.lastname: Meng
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Xuyang
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Geriatric, Yan'an Hospital Affiliated of Kunming Medical University, Kunming, 650051, China.
authors.forename: Linyao
authors.initials: L
authors.lastname: Fu
mesh_terms: D000368:Aged; D002469:Cell Separation; D002478:Cells, Cultured; D003071:Cognition; D015140:Dementia, Vascular / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008875:Middle Aged; D011788:Quality of Life; D014470:Umbilical Cord / Q000166:cytology*
keywords: Cell transplantation; Umbilical cord-derived mesenchymal stem cells; Vascular dementia