title: [Role of microtubule severing proteins in cytoskeleton reorganization].
abstract: ATP-dependent severing activity of microtubule severing proteins leads to the local destabilization of the microtubule structure and causes shortening or disassembly of the existing microtubules or formation of the numerous short microtubule fragments that serve as templates during new microtubule polymerization. Microtubule severing protein-dependent rearrangement of the microtubular cytoskeleton plays an important role in the numerous cellular processes including chromosome segregation during meiosis and mitosis, cells migration, dendrites and axon formation, cilia assembly and arrangement of the cortical microtubules in plant cells.
authors.affiliation: Laboratory of Cytoskeleton and Cilia Biology, Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wacławek
authors.affiliation: Laboratory of Cytoskeleton and Cilia Biology, Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Włoga
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities / Q000378:metabolism / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology; D002465:Cell Movement; D002923:Cilia / Q000378:metabolism / Q000502:physiology; D006801:Humans; D000074201:Katanin / Q000378:metabolism / Q000502:physiology*; D008540:Meiosis; D008869:Microtubule-Associated Proteins / Q000378:metabolism / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D018521:Plant Physiological Phenomena; D010944:Plants / Q000378:metabolism; D000074181:Spastin / Q000378:metabolism / Q000502:physiology*
chemical_list: D008869:Microtubule-Associated Proteins; D000255:Adenosine Triphosphate; D000074183:ATPases Associated with Diverse Cellular Activities; C000613810:FIGN protein, human; D000074181:Spastin; C000600349:KATNAL1 protein, human; D000074201:Katanin; C400283:SPAST protein, human
keywords: fidgetin; katanin; microtubule severing proteins; microtubules; spastin