title: Physiological expression of pancreatic somatostatin receptors in 99mTc-HYNIC-TOC scintigraphy.
abstract: OBJECTIVE
  To describe the frequency of head and/or pancreas uncinate process uptake of 99mTc-HYNIC-TOC, to study its nature, and analyze its diagnostic value.
  
  
  METHODS
  Retrospective evaluation of 47 consecutive 99mTc-HYNIC-TOC examinations was conducted. Head and/or pancreas uncinate process uptake was considered to be physiological in patients with normal CT at the same episode and in follow-up. It was analyzed if age or diabetes mellitus was justifying the existence or not of uptake.
  
  
  RESULTS
  32.5% patients showed uptake; 73% of them were mild. 84.6% patients with uptake have no pathology and 4% had neuroendocrine pancreatic disease at CT. Neither the age nor the diabetes mellitus established differences in patients without lesion.
  
  
  CONCLUSIONS
  Near one-third of patients show physiological uptake by head and/or pancreas uncinate process at 99mTc-HYNIC-TOC scintigraphy. It seems that neither the diabetes nor the ages are factors that determine this physiological uptake.
authors.affiliation: Nuclear Medicine Department, University Hospital Miguel Servet, Paseo Isabel la Católica 1-3, 50009, Zaragoza, Spain. ldelacueva@salud.aragon.es.
authors.forename: L
authors.initials: L
authors.lastname: de la Cueva
authors.affiliation: Nuclear Medicine Department, University Hospital Miguel Servet, Paseo Isabel la Católica 1-3, 50009, Zaragoza, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Lloro
authors.affiliation: Nuclear Medicine Department, University Hospital Miguel Servet, Paseo Isabel la Católica 1-3, 50009, Zaragoza, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Sangrós
authors.affiliation: Clínica las Américas, Medellín, Colombia.
authors.forename: L
authors.initials: L
authors.lastname: López Vélez
authors.affiliation: Nuclear Medicine Department, University Hospital Miguel Servet, Paseo Isabel la Católica 1-3, 50009, Zaragoza, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Navarro
authors.affiliation: Radiology Department, University Hospital Miguel Servet, Zaragoza, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Sarria
authors.affiliation: Nuclear Medicine Department, University Hospital Miguel Servet, Paseo Isabel la Católica 1-3, 50009, Zaragoza, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Álvarez
authors.affiliation: Nuclear Medicine Department, University Hospital Miguel Servet, Paseo Isabel la Católica 1-3, 50009, Zaragoza, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Abós
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D015282:Octreotide / Q000031:analogs & derivatives* / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000378:metabolism*; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D011877:Radionuclide Imaging / Q000379:methods*; D017481:Receptors, Somatostatin / Q000378:metabolism*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D017481:Receptors, Somatostatin; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; D015282:Octreotide
keywords: 99mTc-HYNIC-TOC; Neuroendocrine tumors; Pancreas uncinate process; Somatostatin receptor scintigraphy