title: Expression of phosphatase of regenerating liver-3 is associated with prognosis of Wilms' tumor.
abstract: OBJECTIVE
  The current study was undertaken to explore the clinical and prognostic value of phosphatase of regenerating liver-3 (PRL-3) expression in Wilms' tumor.
  
  
  METHODS
  Seventy-six patients with Wilms' tumor in Qilu Hospital from January 2003 to July 2009 were enrolled in the study. Protein expression level of PRL-3 was examined by immunohistochemical staining, and the correlation between PRL-3 expression and histopathological parameters, clinical variables, and outcome of patients with Wilms' tumor were analyzed.
  
  
  RESULTS
  We found that 19% of patients with unfavorable histology had tumor recurrence and 16% of patients died following the operation. PRL-3 was expressed in 15 out of 76 tumors (19%) and expressed highly in unfavorable histology Wilms' tumor (P=0.04). PRL-3 protein expression level was correlated to 2.5-fold increase in recurrence rate of Wilms' tumor (P=0.06) without any statistically significant difference. However, in favorable histology Wilms' tumor, PRL-3 expression was correlated to an increase of 3.4-fold in recurrence rate (P=0.03).
  
  
  CONCLUSIONS
  The expression of PRL-3 protein was correlated with an increased recurrence rate of favorable histology Wilms' tumor. PRL-3 may serve as a promising biomarker for predicting patients with high risk of Wilms' tumor. Further investigations are warranted to investigate the clinical function of PRL-3 in Wilms' tumor.
authors.affiliation: Department of Pediatric Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province.
authors.forename: Fengyin
authors.initials: F
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou, Fujian Province; Department of Vascular Surgery, Xinzhou City People's Hospital, Xinzhou, Shanxi Province, People's Republic of China.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of General Surgery, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou, Fujian Province.
authors.forename: Lie
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Vascular Surgery, Xinzhou City People's Hospital, Xinzhou, Shanxi Province, People's Republic of China.
authors.forename: Changfeng
authors.initials: C
authors.lastname: Jiao
keywords: Wilms’ tumor; prognosis; recurrence; tumorigenesis