title: Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy.
abstract: The platelet-derived growth factor receptors alpha and beta (PDGFRα and PDGFRβ) mark fibroadipogenic progenitor cells/fibroblasts and pericytes in skeletal muscle, respectively. While the role that these cells play in muscle growth and development has been evaluated, it was not known whether the PDGF receptors activate signaling pathways that control transcriptional and functional changes during skeletal muscle hypertrophy. To evaluate this, we inhibited PDGFR signaling in mice subjected to a synergist ablation muscle growth procedure, and performed analyses 3 and 10 days after induction of hypertrophy. The results from this study indicate that PDGF signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.
authors.affiliation: Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.|Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.|Section of Plastic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Kristoffer B
authors.initials: KB
authors.lastname: Sugg
authors.affiliation: Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Korn
authors.affiliation: Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Dylan C
authors.initials: DC
authors.lastname: Sarver
authors.affiliation: Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Markworth
authors.affiliation: Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.|Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Mendias
mesh_terms: D000125:Achilles Tendon / Q000601:surgery; D000818:Animals; D000831:Animals, Newborn; D001562:Benzimidazoles / Q000494:pharmacology; D005109:Extracellular Matrix / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006984:Hypertrophy / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D016474:Weight-Bearing
chemical_list: D001562:Benzimidazoles; C497448:CP-673,451; D010982:Platelet-Derived Growth Factor; D011804:Quinolines; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta
keywords: extracellular matrix; platelet-derived growth factor; skeletal muscle