title: Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective.
abstract: Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recent technological progresses in mass spectrometry, nuclear magnetic resonance spectroscopy, and chromatography have significantly enhanced the developments and applications of metabolic profiling of lipids in more complex biological samples. As many diseases reveal a notable change in lipid profiles compared with that of healthy people, lipidomics have also been broadly introduced to scientific research on diseases. Exploration of lipid biochemistry by lipidomics approach will not only provide insights into specific roles of lipid molecular species in health and disease, but it will also support the identification of potential biomarkers for establishing preventive or therapeutic approaches for human health. This chapter aims to illustrate how lipidomics can contribute for understanding the biological mechanisms inherent to schizophrenia and why lipids are relevant biomarkers of schizophrenia. The application of lipidomics in clinical studies has the potential to provide new insights into lipid profiling and pathophysiological mechanisms underlying schizophrenia. The future perspectives of lipidomics in mental disorders are also discussed herein.
authors.affiliation: Department of Psychiatry, Federal University of São Paulo (UNIFESP), Research Building II, Rua Pedro de Toledo 669-3, Floor Funds - Vila Clementino, 04039-032, São Paulo, Brazil.
authors.forename: Sumit
authors.initials: S
authors.lastname: Sethi
authors.affiliation: Department of Pharmacology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Mirian A F
authors.initials: MA
authors.lastname: Hayashi
authors.affiliation: Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.
authors.forename: Banny S
authors.initials: BS
authors.lastname: Barbosa
authors.affiliation: Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.
authors.forename: João G M
authors.initials: JG
authors.lastname: Pontes
authors.affiliation: Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.
authors.forename: Ljubica
authors.initials: L
authors.lastname: Tasic
authors.affiliation: Department of Psychiatry, Federal University of São Paulo (UNIFESP), Research Building II, Rua Pedro de Toledo 669-3, Floor Funds - Vila Clementino, 04039-032, São Paulo, Brazil. elisabrietzke@hotmail.com.
authors.forename: Elisa
authors.initials: E
authors.lastname: Brietzke
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D019295:Computational Biology; D006801:Humans; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics / Q000379:methods*; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D008055:Lipids
keywords: Biomarkers; Lipidomics; Liquid Chromatography; Mass Spectrometry; Metabolomics; Nuclear Magnetic Resonance Spectroscopy; Schizophrenia