title: Patient-reported outcomes with direct-acting antivirals for the treatment of chronic hepatitis C: current knowledge and outstanding issues.
abstract: Patient-reported outcomes (PROs) play a key role in the evaluation of direct-acting antivirals (DAA) for the treatment of chronic hepatitis C (CHC). The main PROs of particular interest in CHC include quality of life (QoL), fatigue and its functional repercussions, work productivity, adherence to treatment, and risk behaviors. Areas covered: This study summarizes the body of knowledge regarding PROs in CHC with DAA-based therapy. Outstanding related issues are presented and discussed. Expert commentary: Current knowledge on PROs with CHC mainly relies on clinical trial data. All-oral DAA regimens are associated with minimal QoL impairment and symptom burden, rapid recovery once treatment has ended, and improvement in PROs for a non-negligible proportion of treated patients, especially HCV clearers. Further research is needed to analyze both long-term changes in PROs, and PROs in specific populations including people who use drugs, comorbid patients and patients at risk of reinfection.
authors.affiliation: a Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille , France.|b ORS PACA, Observatoire régional de la santé Provence-Alpes-Côte d'Azur , Marseille , France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Marcellin
authors.affiliation: a Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille , France.|b ORS PACA, Observatoire régional de la santé Provence-Alpes-Côte d'Azur , Marseille , France.
authors.forename: Perrine
authors.initials: P
authors.lastname: Roux
authors.affiliation: a Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille , France.|b ORS PACA, Observatoire régional de la santé Provence-Alpes-Côte d'Azur , Marseille , France.
authors.forename: Camelia
authors.initials: C
authors.lastname: Protopopescu
authors.affiliation: c EA 7334 REMES, Patient-Centered Outcomes Research , University Paris-Diderot, Sorbonne Paris Cité , Paris , France.|d URC-ECO, Hôpital Hôtel-Dieu, AP-HP , Paris , France.|e Service de Médecine Interne et d'Immunologie Clinique , Hôpital Bicêtre, AP-HP , Kremlin-Bicêtre , France.
authors.forename: Martin
authors.initials: M
authors.lastname: Duracinsky
authors.affiliation: a Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille , France.|b ORS PACA, Observatoire régional de la santé Provence-Alpes-Côte d'Azur , Marseille , France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Spire
authors.affiliation: a Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille , France.|b ORS PACA, Observatoire régional de la santé Provence-Alpes-Côte d'Azur , Marseille , France.
authors.forename: Maria Patrizia
authors.initials: MP
authors.lastname: Carrieri
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004526:Efficiency; D004651:Employment; D016174:Hepacivirus / Q000187:drug effects* / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D055118:Medication Adherence; D000071066:Patient Reported Outcome Measures; D011788:Quality of Life; D012074:Remission Induction; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents
keywords: Chronic infection; direct-acting antivirals; drug users; fatigue; hepatitis C; key populations; patient-reported outcomes; quality of life; reinfection; risk behaviors