title: Clinical Relevance of Steroid Use in Neuro-Oncology.
abstract: Corticosteroids are commonly used in the management of primary central nervous system (CNS) tumors and CNS metastases to treat cancer- and treatment-related cerebral edema and improve neurologic function. However, they are also associated with significant morbidity and mortality, given their wide range of adverse effects.
  
  
  
  To review the mechanism of action, pharmacology, and toxicity profile of corticosteroids and to critically appraise the evidence that supports their use in neuro-oncologic practice based on the latest scientific and clinical data.
  
  
  
  Recent data suggest that corticosteroids may negatively impact survival in glioma patients. In addition, corticosteroids should be incorporated as a standard criterion to assess a patient's clinical and radiographic response to treatment. Corticosteroids should be used judiciously in neuro-oncologic patients, given the potential deleterious effects on clinical outcome and patient survival. Anti-angiogenic agents, which lack these adverse effects, may be a reasonable alternative to corticosteroids.
authors.affiliation: Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.|Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
authors.forename: K Ina
authors.initials: KI
authors.lastname: Ly
authors.affiliation: Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA. patrick_wen@dfci.harvard.edu.
authors.forename: Patrick Y
authors.initials: PY
authors.lastname: Wen
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D001929:Brain Edema / Q000209:etiology; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005910:Glioma / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D060787:Neoplasm Grading
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Brain metastases; Brain tumor; Cerebral edema; Corticosteroids; Response assessment; Steroids