title: Start me up: Revision of evidences that AtGRP3 acts as a potential switch for AtWAK1.
abstract: AtGRP3 is a glycine-rich protein from Arabidopsis thaliana shown to interact with the extracellular domain of the receptor-like kinase (RLK) AtWAK1. Based on previous functional data for AtWAK1, a model was proposed that AtGRP3 when bound to this RLK would negatively regulate its kinase activity, inhibiting cell expansion. Here, we review recent functional studies on AtGRP3 that corroborate this model and suggest that AtGRP3/AtWAK1 complex regulates also defense signaling pathways. On the other hand, we show new data on AtGRP3-overexpressing plants indicating that its role in aluminum signaling pathways, as previously observed for elicitor signaling, seems to be more complex than a simple negative regulator.
authors.affiliation: a Laboratório de Genômica Funcional e Transdução de Sinal , Departamento de Genética, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
authors.forename: Amanda
authors.initials: A
authors.lastname: Mangeon
authors.affiliation: a Laboratório de Genômica Funcional e Transdução de Sinal , Departamento de Genética, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
authors.forename: Adriana Dias
authors.initials: AD
authors.lastname: Menezes-Salgueiro
authors.affiliation: a Laboratório de Genômica Funcional e Transdução de Sinal , Departamento de Genética, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Sachetto-Martins
mesh_terms: D000535:Aluminum / Q000633:toxicity; D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D029681:Arabidopsis Proteins; D008565:Membrane Proteins; D000535:Aluminum; D011494:Protein Kinases; C101093:WAK1 protein, Arabidopsis
keywords: Al tolerance; cell expansion; defense signaling; glycine-rich protein; receptor-like kinase