title: The Effects of Dexmedetomidine on Microelectrode Recordings of the Subthalamic Nucleus during Deep Brain Stimulation Surgery: A Retrospective Analysis.
abstract: The placement of subthalamic nucleus (STN) deep brain stimulation (DBS) electrodes can be facilitated by intraoperative microelectrode recording (MER) of the STN.
  
  
  
  Optimal anesthetic management during surgery remains unclear because of a lack of quantitative data of the effect of anesthetics on MER. Therefore, we measured the effects of dexmedetomidine (DEX) on MER measures of the STN commonly taken intraoperatively.
  
  
  
  MER from 45 patients was retrospectively compared between patients treated with remifentanil (REMI) alone or both REMI and DEX, which are the 2 main standards of care at our center. The measures examined were population activity, such as root mean square, STN length, and number of passes yielding STN, and the single-neuron measures of firing rate and variability.
  
  
  
  The addition of DEX does not affect population measures (number of passes: DEX+REMI, n = 68, REMI only, n = 154), or neuronal firing rates (number of neurons: DEX+REMI, n = 64, REMI only, n = 72), but firing rate variability was reduced.
  
  
  
  In this cohort, population-based measures routinely used for electrode placement in the STN were unaffected by DEX when added to REMI. Neuronal firing rates were also unaffected, but their variability was reduced, even beyond 20 min after cessation.
authors.affiliation: Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Letha
authors.initials: L
authors.lastname: Mathews
authors.forename: Corrie R
authors.initials: CR
authors.lastname: Camalier
authors.forename: Koffi M
authors.initials: KM
authors.lastname: Kla
authors.forename: Martina D
authors.initials: MD
authors.lastname: Mitchell
authors.forename: Peter E
authors.initials: PE
authors.lastname: Konrad
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Neimat
authors.forename: Kenneth G
authors.initials: KG
authors.lastname: Smithson
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000368:Aged; D046690:Deep Brain Stimulation; D020927:Dexmedetomidine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D009474:Neurons / Q000187:drug effects*; D010300:Parkinson Disease / Q000601:surgery*; D010880:Piperidines / Q000494:pharmacology; D000077208:Remifentanil; D012189:Retrospective Studies; D020531:Subthalamic Nucleus / Q000187:drug effects / Q000601:surgery*
chemical_list: D010880:Piperidines; D020927:Dexmedetomidine; D000077208:Remifentanil