title: Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement.
abstract: Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (-)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.
authors.affiliation: Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. fei.liu@mq.edu.au.
authors.forename: Alpesh Ramanlal
authors.initials: AR
authors.lastname: Patel
authors.forename: Ari
authors.initials: A
authors.lastname: Hardianto
authors.forename: Shoba
authors.initials: S
authors.lastname: Ranganathan
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D054879:Halogenation; D008024:Ligands; D011506:Proteins / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D011506:Proteins; D000255:Adenosine Triphosphate