title: Mercy Pregnancy and Emotional Well-being Study (MPEWS): Understanding maternal mental health, fetal programming and child development. Study design and cohort profile.
abstract: Maternal mental health represents a significant global health burden. The Mercy Pregnancy and Emotional Well-being Study (MPEWS) was established to provide a comprehensive investigation of early developmental mechanisms and modifiers for maternal, fetal and child emotional well-being. MPEWS is a prospective, longitudinal study from pregnancy to 36 months postpartum that includes diagnostic measures of maternal mental health, observational measures of the mother-infant relationship, measures of child development, and repeat biological sampling. A total of 282 pregnant women were recruited in early pregnancy from the Mercy Hospital for Women in Melbourne, Australia, including 52 women on antidepressant medication, 31 non-medicated women meeting diagnostic criteria for current unipolar depression or dysthymia, and 65 women with a past history of depression. Sample recruitment characteristics included a mean age of 31 years and average gestation of 16 weeks. The MPEWS cohort was comparable to national averages for Australia on key pregnancy and birth variables. Those participants taking antidepressant medication had higher mean Edinburgh Postnatal Depression Scale (EPDS) and State Trait Anxiety Inventory (STAI) scores than the cohort as a whole but were comparable on other key variables. The MPEWS protocol provides a unique opportunity to evaluate the impact of pregnancy mental health on future maternal mental health and child development to aid the development of evidence-based interventions. The study is open for collaborative proposals via approach to the principal investigators.
authors.affiliation: School of Psychology and Exercise Science, Murdoch University, Perth, Australia.|School of Medicine, University of Notre Dame, Fremantle, Australia.|Fiona Stanley Hospital, Perth, Australia.
authors.forename: Megan
authors.initials: M
authors.lastname: Galbally
authors.affiliation: Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands.
authors.forename: Marinus
authors.initials: M
authors.lastname: van IJzendoorn
authors.affiliation: Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Permezel
authors.affiliation: Murdoch Children's Research Institute, Royal Children's Hospital, and Department of Paediatrics, University of Melbourne, Parkville, Australia.
authors.forename: Richard
authors.initials: R
authors.lastname: Saffery
authors.affiliation: Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia.|Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Australia.
authors.forename: Martha
authors.initials: M
authors.lastname: Lappas
authors.affiliation: Murdoch Children's Research Institute, Royal Children's Hospital, and Department of Paediatrics, University of Melbourne, Parkville, Australia.|Inserm U1061, University Montpellier, Montpellier, France.
authors.forename: Joanne
authors.initials: J
authors.lastname: Ryan
authors.affiliation: Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: van Rossum
authors.affiliation: School of Psychology and Speech Pathology, Curtin University, Bentley, Australia.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Johnson
authors.affiliation: Human Development and Family Studies, The Pennsylvania State University, State College, Pennsylvania, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Teti
authors.affiliation: School of Psychology and Exercise Science, Murdoch University, Perth, Australia.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lewis
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis*; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D009034:Mother-Child Relations / Q000523:psychology*; D010549:Personal Satisfaction; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000188:drug therapy; D013315:Stress, Psychological / Q000175:diagnosis*; D014739:Victoria
keywords: antidepressants; anxiety; child development; depression; fetal development; perinatal mental health