title: Salivary mucins promote the coexistence of competing oral bacterial species.
abstract: Mucus forms a major ecological niche for microbiota in various locations throughout the human body such as the gastrointestinal tract, respiratory tract and oral cavity. The primary structural components of mucus are mucin glycoproteins, which crosslink to form a complex polymer network that surrounds microbes. Although the mucin matrix could create constraints that impact inhabiting microbes, little is understood about how this key environmental factor affects interspecies interactions. In this study, we develop an experimental model using gel-forming human salivary mucins to understand the influence of mucin on the viability of two competing species of oral bacteria. We use this dual-species model to show that mucins promote the coexistence of the two competing bacteria and that mucins shift cells from the mixed-species biofilm into the planktonic form. Taken together, these findings indicate that the mucus environment could influence bacterial viability by promoting a less competitive mode of growth.
authors.affiliation: Biological Sciences in Dental Medicine, Harvard University, Cambridge, MA, USA.|Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Erica Shapiro
authors.initials: ES
authors.lastname: Frenkel
authors.affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Katharina
authors.initials: K
authors.lastname: Ribbeck
mesh_terms: D018407:Bacterial Physiological Phenomena; D018441:Biofilms; D006801:Humans; D056265:Microbial Interactions; D050296:Microbial Viability; D008954:Models, Biological; D009077:Mucins / Q000502:physiology*; D012471:Salivary Proteins and Peptides / Q000502:physiology*
chemical_list: D009077:Mucins; D012471:Salivary Proteins and Peptides