title: Insulin glargine 300 units/mL: a guide for healthcare professionals involved in the management of diabetes.
abstract: Insulin glargine 300 units/mL: Insulin glargine 300 units/mL (Gla-300) is a formulation of insulin glargine that delivers the same number of insulin units in one-third of the injectable volume of insulin glargine 100 units/mL (Gla-100). Glucose control: Recently approved in the United States and in Europe for use in type 1 and type 2 diabetes, Gla-300 has a more constant and evenly distributed glucose-lowering effect compared with Gla-100, with a duration of action beyond 24 hours and lower within-day and between-day intra-individual variability in blood glucose levels. These benefits translate into predictable and sustained glucose control from a once-daily injection, with potential for fewer hypoglycemia episodes and less weight gain.
  
  
  
  Case studies are presented to highlight the potential clinical benefits and considerations associated with initiating treatment with Gla-300 in people with type 1 and type 2 diabetes.
authors.affiliation: a Ministry Medical Group , Stevens Point , WI , USA.
authors.forename: Jodi
authors.initials: J
authors.lastname: Strong
authors.affiliation: b Henry Ford Medical Center, Division of Endocrinology, Diabetes, Bone and Mineral Disorders , Detroit , MI , USA.
authors.forename: Davida
authors.initials: D
authors.lastname: Kruger
authors.affiliation: c Riverside Medical Associates , Riverdale , MD , USA.
authors.forename: Lucia
authors.initials: L
authors.lastname: Novak
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy*; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000494:pharmacology; D000069036:Insulin Glargine / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D000069036:Insulin Glargine
keywords: Hypoglycemia; insulin glargine 300 units/mL; insulin therapy; treatment case study