title: The temporal trend of vascular function in women with gestational diabetes.
abstract: The objective of the study was to assess the temporal changes in vascular function during pregnancy in healthy women and in those with gestational diabetes mellitus (GDM). Assessment of vascular function was done at three time points, 11-13+6weeks+days, 20-22+6weeks+daysand 30-32+6weeks+days, by flow-mediated dilatation (FMD), augmentation index (AIx) and carotid-radial pulse wave velocity (crPWV) in women ( n=100) with singleton pregnancies. Out of the 100 women, 20 developed GDM, who were compared with 20 healthy, age-matched pregnant women in a nested case-control design. Women with GDM had lower FMD% in the third compared to the first trimester (6.77 (4.36-9.96) vs 9.76 (6.66-16.61)%; p = 0.026); however, FMD% was similar on inter-group comparison between GDM and healthy pregnancies. AIx was significantly higher in GDM than healthy pregnancies at both first (15.35 ± 10.57 vs 6.45 ± 9.81%; p<0.05) and second trimesters (15.00 ± 8.44 vs 2.50 ± 9.01%; p<0.05). A higher AIx in early pregnancy differentiates women with GDM from those with healthy pregnancies.
authors.affiliation: 1 Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Garg
authors.affiliation: 1 Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Smriti
authors.initials: S
authors.lastname: Badhwar
authors.affiliation: 1 Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Jaryal
authors.affiliation: 2 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Kachhawa
authors.affiliation: 1 Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Kishore Kumar
authors.initials: KK
authors.lastname: Deepak
authors.affiliation: 2 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Alka
authors.initials: A
authors.lastname: Kriplani
mesh_terms: D000328:Adult; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011264:Pregnancy Trimesters; D011379:Prognosis; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D013997:Time Factors; D016216:Ultrasonography, Prenatal / Q000379:methods; D059289:Vascular Stiffness; D014664:Vasodilation; D055815:Young Adult
keywords: arterial stiffness; flow-mediated dilatation; gestational diabetes mellitus; pregnancy; vascular function