title: A Micelle Self-Assembled from Doxorubicin-Arabinoxylan Conjugates with pH-Cleavable Bond for Synergistic Antitumor Therapy.
abstract: Nanomedicine offers new hope to overcome the low solubility and high side toxicity to normal tissue appeared in traditional chemotherapy. The biocompatibility and intracellular drug accumulation is still a big challenge for the nano-based formulations. Herein, a medical-used biocompatible arabinoxylan (AX) is used to develop to delivery chemodrug doxorubicin (DOX). The solubility of DOX is obviously enhanced via the hydrogen bond formed with AX which results in an amphiphilic AX-DOX. A micelle with pH-cleavable bond is thus self-assembled from such AX-DOX with DOX core and AX shell. The inner DOX can be easily released out at low intracellular pH, which obviously enhanced its in vitro cytotoxicity against breast cancer cells (MCF-7). Interestingly, an unexpected apoptosis is evoked except for the proliferation inhibition. Moreover, the therapeutic effects are further synergistically promoted by the enhanced permeability and retention (EPR) and intracellular pH-triggered drug release. Consequently, the in vivo intratumor accumulation of DOX, the tumor inhibition was significantly promoted after intravenous administration to the Balb/c nude mice bearing MCF-7 tumors. These in vitro/vivo results indicated that the AX-DOX micellular formulation holds high potential in cancer therapy.
authors.affiliation: College of Pharmacy & Institute of Biopharmaceutical Research, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong, 252000, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, People's Republic of China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Dong
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Chong
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Tai
authors.initials: T
authors.lastname: Yu
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Fulei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.affiliation: College of Pharmacy & Institute of Biopharmaceutical Research, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong, 252000, People's Republic of China. junhanmail@163.com.|International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China. junhanmail@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Han
authors.affiliation: College of Pharmacy & Institute of Biopharmaceutical Research, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong, 252000, People's Republic of China. liwei@smmu.edu.cn.|International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of China. liwei@smmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
keywords: Biocompatibility; Micelle; Nanomedicine; Synergistic antitumor therapy; pH-cleavable bond