title: Effect of telmisartan and enalapril on ventricular remodeling and kidney prognosis of patients with coronary artery disease complicated with diabetic nephropathy.
abstract: The aim of the present study was to compare the value of telmisartan and enalapril on ventricular remodeling and kidney prognosis of patients with coronary artery disease complicated with diabetic nephropathy, and provide discussion on clinical reasonably chosen medicine. A total of 60 cases of coronary artery disease complicated with diabetic nephropathy were randomly divided for telmisartan (80 mg/day) treatment (n=32), enalapril (10 mg/day) treatment (n=28), while the rest of the therapy was kept the same. After 12 weeks, the clinical effects were compared between different groups. It was found that in comparison with enalapril group, the left ventricular ejection fraction of telmisartan group was significantly higher, and left ventricular end-diastolic diameter was significantly lower (P<0.05). The serum creatinine level and 24-h protein of telmisartan group were significantly lower than that for the enalapril group (P<0.05). In conclusion, the regular telmisartan treatment for patients with coronary artery disease complicated with diabetic nephropathy is better than enalapril on ventricular remodeling and kidney prognosis.
authors.affiliation: Department of Cardiovascular Medicine, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Cardiovascular Medicine, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Fucheng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Medicine, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Medicine, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Shuhong
authors.initials: S
authors.lastname: Su
authors.affiliation: Department of Cardiovascular Medicine, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Cardiovascular Medicine, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Wang
keywords: Scr; coronary artery disease; diabetic nephropathy; enalapril; left ventricular ejection fraction; left ventricular end-diastolic diameter; telmisartan