title: [The results of SPRINT study from the point of nephrology].
abstract: There is no consensus of the opinion that the value of systolic blood pressure (SBP) is the most favourable for the treatment of hypertension in patients with chronic kidney disease (CKD). The interventional study SPRINT (The Systolic Blood Pressure Intervention Trial) demonstrated the significant reduction in major cardiovascular events and overall mortality with intensive control of SBP (< 120 mm Hg) in individuals with high risk, including those with CKD and mild proteinuria. Nephrologists should take into account the results of the SPRINT study in the determination of the optimal SBP in patients with CKD, but at the same time they pay the attention to the early detection of adverse events related to treatment, including disorders of electrolyte balance, acute renal impairment, hypotension, and side effects of medications.Key words: acute kidney injury - cardiovascular events - glomerular filtration rate - chronic kidney disease - proteinuria - systolic blood pressure.
authors.forename: Václav
authors.initials: V
authors.lastname: Monhart
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D013599:Systole
chemical_list: D000959:Antihypertensive Agents