title: Validation of a Behavioral Approach for Measuring Saccades in Parkinson's Disease.
abstract: Speed and control of saccades are related to disease progression and cognitive functioning in Parkinson's disease (PD). Traditional eye-tracking complexities encumber application for individual evaluations and clinical trials. The authors examined psychometric properties of standalone tasks for reflexive prosaccade latency, volitional saccade initiation, and saccade inhibition (antisaccade) in a heterogeneous sample of 65 PD patients. Demographics had minimal impact on task performance. Thirty-day test-retest reliability estimates for behavioral tasks were acceptable and similar to traditional eye tracking. Behavioral tasks demonstrated concurrent validity with traditional eye-tracking measures; discriminant validity was less clear. Saccade initiation and inhibition discriminated PD patients with cognitive impairment. The present findings support further development and use of the behavioral tasks for assessing latency and control of saccades in PD.
authors.affiliation: a Department of Neurology , Medical University of South Carolina , Charleston.
authors.forename: Travis H
authors.initials: TH
authors.lastname: Turner
authors.affiliation: a Department of Neurology , Medical University of South Carolina , Charleston.
authors.forename: Jenna B
authors.initials: JB
authors.lastname: Renfroe
authors.affiliation: a Department of Neurology , Medical University of South Carolina , Charleston.
authors.forename: Amy
authors.initials: A
authors.lastname: Duppstadt-Delambo
authors.affiliation: a Department of Neurology , Medical University of South Carolina , Charleston.|b Ralph H. Johnson VAMC , Charleston , South Carolina.
authors.forename: Vanessa K
authors.initials: VK
authors.lastname: Hinson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000067290:Behavior Rating Scale / Q000706:statistics & numerical data*; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D011594:Psychometrics; D015203:Reproducibility of Results; D012438:Saccades / Q000502:physiology*
keywords: Parkinson's disease; behavioral test; cognition; dementia; eye tracking; mild cognitive impairment; saccade; saccadic eye movements