title: Non-high-density lipoprotein cholesterol predicts nonfatal recurrent myocardial infarction in patients with ST segment elevation myocardial infarction.
abstract: BACKGROUND
  Lipids, which are associated with atherogenesis, clotting, and the fibrinolytic pathway, may be important prognostic indicators of recurrent myocardial infarction. The aim of this study was to determine the predictive value of baseline lipid fractions for nonfatal recurrent myocardial infarction in patients with ST segment elevation myocardial infarction 2 years after primary percutaneous coronary intervention in China.
  
  
  METHODS
  Cox proportional-hazards models were used to evaluate the association between potential risk factors, including lipid fractions, and the occurrence of nonfatal recurrent myocardial infarction in 2402 consecutive patients who underwent primary percutaneous coronary intervention for ST segment elevation myocardial infarction.
  
  
  RESULTS
  The cumulative incidence of recurrent myocardial infarction was 2.7% at 1 year, 3.8% at 2 years, and 5.8% at 3 years after percutaneous coronary intervention. The effects of collinearity of lipids were investigated. In concerning the principal components analysis, composing factor 1 (scoring factors were 0.689 for non-HDL, 0.702 for LDL, 0.182 for HDL) which had eigenvalues of 1.86 and explained 62% of the variability among lipid cholesterols was significantly associated with recurrent MI in the final adjusted analysis of the lipid cholesterols principal components. Non-high-density lipoprotein cholesterol was the strongest independent predictor of nonfatal recurrent myocardial infarction. The adjusted hazards ratios for nonfatal recurrent myocardial infarction were 1.26 (95% confidence interval (CI): 1.05-1.51) for non-high-density lipoprotein cholesterol, 1.17 (95% CI: 0.99-1.39) for low-density lipoprotein and 1.15 (95% CI: 0.95-1.40) for HDL. After adjusting for gender and age, the odds ratio for patients in the highest non-high-density lipoprotein cholesterol quartile was 2.10 (95% CI: 1.19-3.72).
  
  
  CONCLUSIONS
  Non-high-density lipoprotein cholesterol value is a stronger predictor of nonfatal recurrent myocardial infarction than other lipid risk factors in patients with ST segment elevation myocardial infarction. Moreover, the occurrence of reinfarction after percutaneous coronary intervention was highest for patients in the highest non-high-density lipoprotein cholesterol quartile.
  
  
  BACKGROUND
  http://www.chictr.org.cn/edit.aspx?pid=13583&htm=4 , registration number: ChiCTR-EPC-16008199, date of registration:2013.01.01.
authors.affiliation: The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.affiliation: The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Zhang
authors.affiliation: The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.|Laboratory for Cardiovascular Diseases, Institute of Translational Medicine, Changchun, China.|Key Laboratory for Cardiovascular Mechanism of Traditional Chinese Medicine, First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China. 1071927028@qq.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012008:Recurrence; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000401:mortality
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
keywords: Lipid; Primary percutaneous coronary intervention; Recurrent myocardial infarction; ST segment elevation myocardial infarction; Serum transaminase