title: [A Study of Therapy for Locally Advanced Breast Cancer with Metastasis].
abstract: We reviewed 21 patients with locally advanced breast cancer with distant metastasis.The median age was 61 years.The median time to presentation at hospital was 13 months, and the median neoplasm diameter on the first visit was 10 cm.The main histological type was scirrhous carcinoma.Sixteen cases tested positive for hormone receptor(76%), 4 tested positive for HER2(19%), and 3 were triple negative(14%).Four patients underwent surgery.The techniques performed included mastectomy and axillary lymph node dissection.Three patients experienced local recurrence.The first-line treatment was surgery for 1 patient, chemotherapy for 12 patients, hormonal therapy for 7 patients, and trastuzumab for the HER2 positive patients.The median follow-up period was 49 months.The patients for where an operation was performed were 49 months and the operation not- enforcement patients were 54 months.If treatment is possible for patients with locally advanced breast cancer with distant metastasis, multidisciplinary treatment according to individual patient characteristics is recommended. In the case of surgical treatment, careful consideration must also be given to these characteristics.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Aoki
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ando
authors.forename: Akira
authors.initials: A
authors.lastname: Fukuda
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ami
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Imai
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ganno
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sugita
authors.forename: Hideaki
authors.initials: H
authors.lastname: Amagasa
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Arai
authors.forename: Shikofumi
authors.initials: S
authors.lastname: Tei
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Akita
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis