title: Breast cancer metastasis suppressor 1 (BRMS1) suppresses prostate cancer progression by inducing apoptosis and regulating invasion.
abstract: Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as a metastasis suppressor gene in human breast cancer.
  
  
  
  A recent study has established an association between BRMS1 with the clinical stage and different pathology grades of prostate cancer. However, whether BRMS1 plays a role in prostate cancer has not been elucidated.
  
  
  
  In this study, we found that overexpression of BRMS1 in PC-3 cells induced apoptosis and inhibited invasion; moreover, we found that overexpression BRMS1 was associated with the suppressed expression of EMMPRIN.
  
  
  
  Taken together, our results show that BRMS1 may suppress progression and metastasis of prostate cancer through modulating EMMPRIN expression.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. lchlv439@sina.com.
authors.forename: H-M
authors.initials: HM
authors.lastname: Zhang
authors.forename: Q-D
authors.initials: QD
authors.lastname: Qiao
authors.forename: H-F
authors.initials: HF
authors.lastname: Xie
authors.forename: J-X
authors.initials: JX
authors.lastname: Wei
mesh_terms: D017209:Apoptosis; D051926:Basigin / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C410024:BRMS1 protein, human; C497886:BSG protein, human; D012097:Repressor Proteins; D051926:Basigin