title: New Insights into mTOR Signal Pathways in Ovarian-Related Diseases: Polycystic Ovary Syndrome and Ovarian Cancer
abstract: mTOR, the mammalian target of rapamycin, is a conserved serine/threonine kinase which belongs to the
  phosphatidyl-linositol kinase-related kinase (PIKK) family. It has two complexes called mTORC1 and mTORC2. It
  is well established that mTOR plays important roles in cell growth, proliferation and differentiation. Over-activation
  of the mTOR pathway is considered to have a relationship with the development of many types of diseases, including
  polycystic ovary syndrome (PCOS) and ovarian cancer (OC). mTOR pathway inhibitors, such as rapamycin and its
  derivatives, can directly or indirectly treat or relieve the symptoms of patients suffering from PCOS or OC. Moreover,
  mTOR inhibitors in combination with other chemical-molecular agents may have extraordinary efficacy. This paper
  will discuss links between mTOR signaling and PCOS and OC, and explore the mechanisms of mTOR inhibitors in
  treating these two diseases, with conclusions regarding the most effective therapeutic approaches.
authors.affiliation: Institute of Biological Science, The Key Laboratory of Biological Toxicology and Ecological Restoration of Hengyang City, School of Pharmaceutical and Biological Science, University of South China, Heng yang 421001, Hunan Province, China. Email: pengcuiying2004@126.com
authors.forename: Ai Ling
authors.initials: AL
authors.lastname: Liu
authors.forename: Hong Qing
authors.initials: HQ
authors.lastname: Liao
authors.forename: Zhi Liang
authors.initials: ZhL
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Cui Lan
authors.initials: CL
authors.lastname: Zhou
authors.forename: Zi Fen
authors.initials: ZF
authors.lastname: Guo
authors.forename: Hong Yan
authors.initials: HY
authors.lastname: Xie
authors.forename: Cui Ying
authors.initials: CY
authors.lastname: Peng
keywords: mTOR signaling pathway; PCOS; ovarian cancer