title: Management of Neonatal Hypotension.
abstract: Hypotension is a common problem in neonates with complex underlying pathophysiology. Although treatment of low blood pressure is common, clinicians must use all available information to target neonates with compromised perfusion. Pharmacotherapy should be tailored to the specific physiologic perturbations of the individual neonate. Dopamine is the most commonly utilized agent and may be the most appropriate agent for septic shock with low diastolic blood pressure. However, alternative therapies should be considered for other etiologies of hypotension, including milrinone and vasopressin for persistent pulmonary hypertension of the newborn and dobutamine for patent ductus arteriosus. Additional studies are required to refine the approach to neonatal hypotension and document the long-term outcomes of treated neonates.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Kalish
mesh_terms: D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004280:Dobutamine / Q000627:therapeutic use*; D004298:Dopamine / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000150:complications; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D007231:Infant, Newborn; D000069451:Long Term Adverse Effects; D020105:Milrinone / Q000627:therapeutic use*; D012772:Shock, Septic / Q000150:complications
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine; D020105:Milrinone; D004298:Dopamine