title: An Addison disease revealed with a serious hyponatremia.
abstract: We present the case of an Addison's disease revealed by a serious hyponatremia. The serum concentration of ACTH and 21-hydroxylase antibodies were increased and lead to the diagnosis. The cortisol blood level was lowered but required to take into account the stress induced by the hospitalisation of the patient. Addison's disease is characterized by the destruction of the adrenal cortex. Autoimmune adrenalitis is the main cause of adrenal insufficiency. Treatment involves normalisation of sodium concentration and corticosteroids replacement. With a good patient compliance, the survival rate of Addisonian patient is similar to that of the normal population. Management of patient requires vigilance because of the occurrence of others autoimmunes diseases during patient life.
authors.affiliation: Laboratoire.
authors.forename: Hadrien
authors.initials: H
authors.lastname: Maguet
authors.affiliation: Unité d'endocrinologie.
authors.forename: Agnès
authors.initials: A
authors.lastname: Carreau
authors.affiliation: Service de réanimation.
authors.forename: Serge
authors.initials: S
authors.lastname: Hautefeuille
authors.affiliation: Service d'accueil urgence, Centre Hospitalier de la Région d'Annecy Genevois, Metz-Tessy, Pringy, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bonnin
authors.affiliation: Laboratoire.
authors.forename: Gaspard
authors.initials: G
authors.lastname: Beaune
mesh_terms: D000224:Addison Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D003128:Coma / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000097:blood; D007010:Hyponatremia / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013255:Steroid 21-Hydroxylase / Q000276:immunology
chemical_list: D001323:Autoantibodies; D000324:Adrenocorticotropic Hormone; D013255:Steroid 21-Hydroxylase; D006854:Hydrocortisone
keywords: Addison disease; anti-21hydroxylase antibodies; cortisol concentration-ACTH; hyponatremia