title: Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps.
abstract: Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium cross talk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.
authors.affiliation: Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Jamie E
authors.identifier: 0000-0002-2644-676X
authors.initials: JE
authors.lastname: Meegan
authors.affiliation: Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Danielle C
authors.initials: DC
authors.lastname: Coleman
authors.affiliation: Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Melanie
authors.initials: M
authors.lastname: Jannaway
authors.affiliation: Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Sarah Y
authors.initials: SY
authors.lastname: Yuan
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000293:injuries*; D065206:Extracellular Traps / Q000502:physiology*; D006801:Humans; D008833:Microcirculation; D018375:Neutrophil Activation; D009504:Neutrophils / Q000502:physiology*; D020239:Receptor Cross-Talk; D015398:Signal Transduction
keywords: endothelial barrier dysfunction; neutrophil extracellular traps; vascular hyperpermeability