title: Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success.
abstract: Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells.
authors.affiliation: National Scientific and Technical Research Council, Buenos Aires, Argentina; Institute of Virology, National Institute of Agricultural Technology, Castelar, Buenos Aires, Argentina.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Jaworski
authors.affiliation: Pharmacological and Botanical Study Center, School of Medicine, University of Buenos Aires , Buenos Aires , Argentina.
authors.forename: Alejandrina
authors.initials: A
authors.lastname: Vendrell
authors.affiliation: Ferrer Advanced Biotherapeutics , Barcelona , Spain.
authors.forename: Sebastián Matias
authors.initials: SM
authors.lastname: Chiavenna
keywords: human immunodeficiency virus; neutralizing antibodies; prophylaxis; reservoir; treatment; vaccine