title: Serum vitamin D, intact parathyroid hormone, and Fetuin A concentrations were associated with geriatric sarcopenia and cardiac hypertrophy.
abstract: With aging, intact parathyroid hormone (iPTH) increases. It plays a crucial role in left ventricular hypertrophy (LVH). Also, 25-hydroxy vitamin D (Vit-D) and iPTH have been observed to be determinants of muscle wasting known as sarcopenia. Fetuin A (FetA), a systemic calcification inhibitor, involves in the development of diastolic heart failure. Hence, we hypothesized that the interplay among FetA, Vit-D and iPTH may contribute to sarcopenic LVH among the elders. We analyzed a database from the Tianliao Old People study with 541 elders (≥65 years) in a Taiwan's suburban community. After excluding patients with renal function impairment, 120/449 (26.7%) patients were diagnosed with sarcopenia. Sarcopenic patients had lower serum Vit-D levels but higher FetA as well as iPTH. Notably, sarcopenic patients with LVH had significantly lower FetA and higher iPTH levels. In multivariate logistic regression analysis, only the increase in iPTH was independently associated with sarcopenic LVH (Odds ratio: 1.05; confidence interval: 1.03-1.08, p = 0.005). Using iPTH >52.3 ng/l as a cutoff point, the sensitivity and specificity was 66% and 84%, respectively. In conclusion, FetA, Vit-D, and iPTH levels were all associated with sarcopenia in this geriatric population. Among them, iPTH specifically indicates patients with sarcopenic LVH.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.|Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.|Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Chang
authors.affiliation: Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Chih-Hsing
authors.initials: CH
authors.lastname: Wu
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ling-Wei
authors.initials: LW
authors.lastname: Hsu
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.|Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Po-Wei
authors.initials: PW
authors.lastname: Chen
authors.affiliation: Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Yu
authors.affiliation: Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Chin-Sung
authors.initials: CS
authors.lastname: Chang
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Tsai
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.|Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Graduate Institute of Clinical Medical Sciences, College of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Ping-Yen
authors.initials: PY
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D055948:Sarcopenia / Q000473:pathology*; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry; D013383:Suburban Population; D013624:Taiwan; D014807:Vitamin D / Q000097:blood*; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis*
chemical_list: C556354:AHSG protein, human; D010281:Parathyroid Hormone; D060749:alpha-2-HS-Glycoprotein; D014807:Vitamin D