title: Crosstalk between the nucleolus and the DNA damage response.
abstract: Nucleolar function and the cellular response to DNA damage have long been studied as distinct disciplines. New research and a new appreciation for proteins holding multiple functional roles, however, is beginning to change the way we think about the crosstalk among distinct cellular processes. Here, we focus on the crosstalk between the DNA damage response and the nucleolus, including a comprehensive review of the literature that reveals a role for conventional DNA repair proteins in ribosome biogenesis, and conversely, ribosome biogenesis proteins in DNA repair. Furthermore, with recent advances in nucleolar proteomics and a growing list of proteins that localize to the nucleolus, it is likely that we will continue to identify new DNA repair proteins with a nucleolar-specific role. Given the importance of ribosome biogenesis and DNA repair in essential cellular processes and the role that they play in diverse pathologies, continued elucidation of the overlap between these two disciplines will be essential to the advancement of both fields and to the development of novel therapeutics.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA. susan.baserga@yale.edu.
authors.forename: L M
authors.identifier: http://orcid.org/0000-0001-6841-059X
authors.initials: LM
authors.lastname: Ogawa
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA. susan.baserga@yale.edu and Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA and Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: S J
authors.identifier: http://orcid.org/0000-0002-7731-8629
authors.initials: SJ
authors.lastname: Baserga
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000235:genetics* / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D009687:Nuclear Proteins