title: A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER.
abstract: We report a 33-year-old male with a left advanced non-seminomatous testicular germ cell tumor (NSGCT) accompanied panic disorder. He had experienced palpitation and hyperpnea in crowds in his twenties. He was admitted to the Department of Otorhinolaryngology with the chief complaint of left neck swelling.18F-fluorodeoxy glucose positron emission tomography/computed tomography (FDG-PET/CT) demonstrated left neck, left supraclavicular, left axillary, and paraaortic lymph node (LN) swelling and left testicular swelling. He was referred to our department. The left testis had enlarged to the size of a fist. He rejected admission at that time, but next day, he was taken to our hospital by an ambulance because he lost consciousness at home. No abnormalities were found in the brain CT and electrocardiogram. He was admitted and left high orchiectomy was performed. The human chorionic gonadotropin (HCG) level had elevated to 9,717 IU/L and alpha fetoprotein level (AFP) had elevated to 427 ng/ml. The histopathological diagnosis was tumors of more than one histological type, mixed forms: seminoma and embryonal carcinoma.He had palpitation and hyperpnea after admission and was diagnosed with panic disorder by a psychiatrist. Psychotropic drugs (fluvoxamine maleate 50 mg/day, alprazolam 0.8 mg/day) were prescribed and the panic attacks disappeared afterwards. The psychiatric social worker supported his mind side. Bleomycin, etoposide, and cisplatin (BEP) therapy was performed for 4 courses. He put on a blanket to his face and came to avoid a conversation with other people during the chemotherapy. He was diagnosed with depression and psychotropic drugs were increased (fluvoxamine maleate 50→75 mg/day, alprazolam 0.8→1.2 mg/day) in quantity.Lymphadenectomies for LN metastases were performed and their histopathological examination revealed the existence of viable embryonal carcinoma in the supraclavicular LN. Etoposide, ifosfamide, and cisplatin (VIP) therapy was performed for 2 courses.The pateint has remained alive without tumor recurrence. Psychotropic drugs were reduced and the recent drug is fluvoxamine maleate 25 mg/day.
authors.affiliation: Department of Urology, Kurobe City Hospital.
authors.forename: Akiou
authors.initials: A
authors.lastname: Okumura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Morii
authors.forename: Masato
authors.initials: M
authors.lastname: Kiriyama
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takamatsu
authors.forename: Masashi
authors.initials: M
authors.lastname: Shimizu
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yasui
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takagawa
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D018236:Carcinoma, Embryonal / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D006063:Chorionic Gonadotropin / Q000097:blood; D003131:Combined Modality Therapy; D016666:Fluvoxamine / Q000008:administration & dosage; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D009378:Neoplasms, Multiple Primary; D009919:Orchiectomy; D016584:Panic Disorder / Q000150:complications* / Q000188:drug therapy; D000072078:Positron Emission Tomography Computed Tomography; D011619:Psychotropic Drugs / Q000008:administration & dosage; D013736:Testicular Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D000509:alpha-Fetoproteins
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D011619:Psychotropic Drugs; D000509:alpha-Fetoproteins; D016666:Fluvoxamine; D000525:Alprazolam