title: Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts.
abstract: A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced byE. coliLPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells.
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy. m.gasparrini@univpm.it.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Gasparrini
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy. tamara.forbe@gmail.com.|Area de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI), Campeche C.P. 24040, Mexico. tamara.forbe@gmail.com.
authors.forename: Tamara Y
authors.initials: TY
authors.lastname: Forbes-Hernandez
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy. f.giampieri@univpm.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giampieri
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy. dolla.bihs@gmail.com.
authors.forename: Sadia
authors.initials: S
authors.lastname: Afrin
authors.affiliation: Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, 60131 Ancona, Italy. b.mezzetti@univpm.it.
authors.forename: Bruno
authors.initials: B
authors.lastname: Mezzetti
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology ''José Mataix", Biomedical Research Centre, University of Granada, Granada, C.P. 18000, Spain. jlquiles@ugr.es.
authors.forename: Josè L
authors.initials: JL
authors.lastname: Quiles
authors.affiliation: Dipartimento di Scienze Biomediche e Sanità Pubblica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy. s.bompadre@univpm.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bompadre
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy. m.a.battino@univpm.it.|Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA), 39011 Santander, Spain. m.a.battino@univpm.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival; D004249:DNA Damage / Q000187:drug effects; D004926:Escherichia coli / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D031985:Fragaria / Q000737:chemistry*; D006801:Humans; D008070:Lipopolysaccharides / Q000009:adverse effects; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D011135:Polysaccharides, Bacterial
keywords: LPS; inflammation; oxidative stress; prevention; strawberry