title: Effects of NSAIDs and hydroxyapatite coating on osseointegration.
abstract: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration.
  
  
  
  Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and grit-blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically.
  
  
  
  HA-coated implants had a significantly better failure load and "percentage of bone-implant contact" than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations.
  
  
  
  Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with grit-blasted implants.
authors.affiliation: 1 Istanbul University, Istanbul Faculty of Medicine, Orthopedic and Traumatology Department, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Salduz
authors.affiliation: 1 Istanbul University, Istanbul Faculty of Medicine, Orthopedic and Traumatology Department, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Dikici
authors.affiliation: 1 Istanbul University, Istanbul Faculty of Medicine, Orthopedic and Traumatology Department, Istanbul, Turkey.
authors.forename: Önder Ismet
authors.initials: ÖI
authors.lastname: Kılıçoğlu
authors.affiliation: 1 Istanbul University, Istanbul Faculty of Medicine, Orthopedic and Traumatology Department, Istanbul, Turkey.
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Balcı
authors.affiliation: 1 Istanbul University, Istanbul Faculty of Medicine, Orthopedic and Traumatology Department, Istanbul, Turkey.
authors.forename: Turgut
authors.initials: T
authors.lastname: Akgul
authors.affiliation: 2 Cukurova University, Faculty of Dentistry, Adana, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kürkçü
authors.affiliation: 2 Cukurova University, Faculty of Dentistry, Adana, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Kurtoğlu
authors.affiliation: 1 Istanbul University, Istanbul Faculty of Medicine, Orthopedic and Traumatology Department, Istanbul, Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Tözün
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D017886:Durapatite / Q000494:pharmacology*; D005269:Femur / Q000601:surgery; D006622:Hip Prosthesis; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D011817:Rabbits; D013718:Tensile Strength; D014025:Titanium
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D014025:Titanium
keywords: HA coating; celecoxib; diclofenac; grit blasted; osseointegration