title: Antimicrobial activity and phytochemical characterization of Carya illinoensis.
abstract: Carya illinoensis is a widespread species, belonging to the Juglandaceae family, commonly known as Pecan. Popularly, the leaves have been used in the treatment of smoking as a hypoglycemic, cleansing, astringent, keratolytic, antioxidant, and antimicrobial agent. The following research aimed to identify for the first time the phytochemical compounds present in the leaves of C. illinoensis and carry out the determination of antimicrobial activity of aqueous and ethanolic extracts. The antimicrobial activity was tested against 20 microorganisms by determining the minimum inhibitory concentration (MIC). Phenolic acids (gallic acid and ellagic acid), flavonoids (rutin), and tannins (catechins and epicatechins) were identified by HPLC-DAD and may be partially responsible for the antimicrobial activity against Gram-positive, Gram-negative, and yeast. The results showed MIC values between 25 mg/mL and 0.78 mg/mL. The extracts were also able to inhibit the production of germ tubes by Candida albicans.
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, RS, Brazil; Laboratory of Pharmacognosy, Centro Universitário Franciscano, Santa Maria, RS, Brazil.
authors.forename: Nathieli Bianchin
authors.initials: NB
authors.lastname: Bottari
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, RS, Brazil.
authors.forename: Leonardo Quintana Soares
authors.initials: LQ
authors.lastname: Lopes
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, RS, Brazil.
authors.forename: Kauana
authors.initials: K
authors.lastname: Pizzuti
authors.affiliation: Laboratory of Oral Microbiology Research, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Camilla
authors.initials: C
authors.lastname: Filippi Dos Santos Alves
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, RS, Brazil.
authors.forename: Marcos Saldanha
authors.initials: MS
authors.lastname: Corrêa
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, RS, Brazil.
authors.forename: Leandro Perger
authors.initials: LP
authors.lastname: Bolzan
authors.affiliation: Laboratory of Pharmacognosy, Centro Universitário Franciscano, Santa Maria, RS, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Zago
authors.affiliation: Laboratory of Microbiology Research, Centro Universitário Franciscano, Santa Maria, RS, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: de Almeida Vaucher
authors.affiliation: Laboratory of Phytochemistry, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Aline Augusti
authors.initials: AA
authors.lastname: Boligon
authors.affiliation: Laboratory of Pharmaceutical Technology, Universidade Regional Integrada do Alto Uruguai (URI), Santiago, Rio Grande do Sul, Brazil.
authors.forename: Janice Luehring
authors.initials: JL
authors.lastname: Giongo
authors.affiliation: Laboratory of Oral Microbiology Research, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Matheus Dellaméa
authors.initials: MD
authors.lastname: Baldissera
authors.affiliation: Laboratory of Oral Microbiology Research, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Roberto Christ Vianna
authors.initials: RC
authors.lastname: Santos
mesh_terms: D000935:Antifungal Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D031325:Carya / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D062385:Hydroxybenzoates / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D064209:Phytochemicals / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013634:Tannins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D005419:Flavonoids; D062385:Hydroxybenzoates; D064209:Phytochemicals; D013634:Tannins; C017616:phenolic acid
keywords: Antimicrobial activity; C. illinoensis; Flavonoids; Germinal tube; Phenols