title: Neurotoxicity Associated With Dimethyl Sulfoxide Used in Allogeneic Stem Cell Transplantation.
abstract: Dimethyl sulfoxide (DMSO) is a cryoprotective agent used in storage of frozen stem cells in stem cell transplantation. Central nervous system side effects of DMSO such as epileptic seizures, stroke, transient global amnesia, and temporary leucoencephalopathy are rarely seen. Here, we report a pediatric patient who developed seizures after DMSO-cryopreserved stem cell infusion and whose magnetic resonance imaging of the brain demonstrated parietal and occipital focal cortical T2-signal intensity increase. DMSO toxicity should be kept in mind in patients who received cryopreserved stem cell infusion and magnetic resonance imaging may be helpful in differential diagnosis of central nervous system involvement.
authors.affiliation: Departments of *Pediatric Hematology †Radiology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Ataseven
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Tüfekçi
authors.forename: Şebnem
authors.initials: Ş
authors.lastname: Yilmaz
authors.forename: Handan
authors.initials: H
authors.lastname: Güleryüz
authors.forename: Hale
authors.initials: H
authors.lastname: Ören
mesh_terms: D000293:Adolescent; D064591:Allografts; D015925:Cryopreservation / Q000379:methods; D003451:Cryoprotective Agents / Q000633:toxicity*; D003937:Diagnosis, Differential; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000000981:diagnostic imaging / Q000209:etiology*; D033581:Stem Cell Transplantation / Q000009:adverse effects*
chemical_list: D003451:Cryoprotective Agents; D004121:Dimethyl Sulfoxide