title: Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity.
abstract: It has widely been accepted that major histocompatibility complex class I molecules (MHC-I) are limited to binding small peptides of 8-10 residues in length. However, this consensus has recently been challenged with the identification of longer peptides (≥11 residues) that can also elicit cytotoxic CD8+ T cell responses. Indeed, a growing number of studies demonstrate that these non-canonical epitopes are important targets for the immune system. As long epitopes represent up to 10% of the peptide repertoire bound to MHC-I molecules, here we review their impact on antigen presentation by MHC-I, TCR recognition, and T cell immunity.
authors.affiliation: .
authors.forename: Tracy M
authors.initials: TM
authors.lastname: Josephs
authors.affiliation: .
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Grant
authors.affiliation: .
authors.forename: Stephanie
authors.initials: S
authors.lastname: Gras
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D011948:Receptors, Antigen, T-Cell
keywords: T cell receptor recognition; antigen presentation; human leukocyte antigen; major histocompatibility complex; tumor peptide; viral peptide