title: Aortoseptal angle and pressure gradient reduction following balloon valvuloplasty in dogs with severe subaortic stenosis.
abstract: BACKGROUND
  To determine the relationship between aortoseptal angle (AoSA) and the short- and long-term systolic pressure gradient (PG) reduction following combined cutting and high-pressure balloon valvuloplasty (CB/HPBV) in dogs with severe subaortic stenosis.
  
  
  METHODS
  Retrospective study of 22 client-owned dogs of various breeds with severe subaortic stenosis (mean left ventricular to aortic PG = 143 mmHg; range = 80-322 mmHg) that underwent CB/HPBV.
  
  
  METHODS
  Initial angiographic and left apical and right-sided parasternal long-axis view echocardiographic video loops were used for measuring the angle between the plane of the interventricular septum and the longitudinal axis of the ascending aorta. The PG reduction ratio immediately after CB/HPBV and 6 and 12 months later were compared with AoSA.
  
  
  RESULTS
  Weak correlations were observed for all instances of PG reduction ratio and AoSA type. Significantly greater mean differences of PG reduction ratio were observed for angles >160° than for angles <160° at 24 h (>160° mean: 54.45, standard error [SE]: ±3.8; <160° mean: 39.88, SE: ±2.09), 6 months (>160° mean: 57.73, SE: ±10.9; <160° mean: 28.22, SE: ±3.42), and 12 months (>160° mean: 76.11, SE: ±17.5; <160° mean: 27.61, SE: ±6.44; p=0.003).
  
  
  CONCLUSIONS
  Dogs with AoSA >160° on right-sided parasternal long-axis view echocardiograms responded with a greater PG reduction following CB/HPBV than did dogs with AoSA <160°. This suggests that AoSA is associated with long-term outcomes of CB/HPBV, and measurement could help in the evaluation of dogs that are candidates for CB/HPBV.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: L
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA. Electronic address: estradaa@ufl.edu.
authors.forename: A H
authors.initials: AH
authors.lastname: Estrada
authors.affiliation: Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Côté
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Powell
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: B
authors.initials: B
authors.lastname: Winter
authors.affiliation: Lamb Consulting, West St. Paul, MN, USA.
authors.forename: K
authors.initials: K
authors.lastname: Lamb
mesh_terms: D000818:Animals; D001020:Aortic Stenosis, Subvalvular / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D063126:Balloon Valvuloplasty / Q000662:veterinary; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D006343:Heart Septal Defects / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: Angiography; Aortic stenosis; Cardiovascular; Congenital; Echocardiography