title: Chemotherapy for dogs with lymph node metastasis from histiocytic sarcomas.
abstract: BACKGROUND
  Histiocytic sarcomas (HS) frequently metastasise, most commonly to visceral sites, but also to regional lymph nodes. Nodal metastases are associated with a poorer prognosis. This retrospective study aimed to evaluate prognostic factors, including the effect of adjuvant chemotherapy, on survival in dogs with nodal, but not systemic, metastases from HS.
  
  
  METHODS
  Retrospective case series of 12 dogs with histologically diagnosed HS metastatic to lymph nodes treated with surgery with and without adjuvant chemotherapy.
  
  
  RESULTS
  All dogs had histological evidence of metastasis to lymph nodes, with no clinical evidence for metastasis to viscera. Eight dogs that received chemotherapy had a median estimated survival of 219 days (range 77-1638 days); 1- and 2-year estimated survival rates were 37.7%. Median survival time for 4 dogs with nodal metastases that did not receive chemotherapy was 57 days (range 39-136 days) with none alive 1 year after surgery CONCLUSION: Survival for dogs with only regional nodal metastases from HS appeared to be improved by adjuvant chemotherapy.
authors.affiliation: Veterinary Oncology Consultants, 379 Lake Innes Drive, Wauchope, New South Wales, Australia.
authors.forename: A S
authors.initials: AS
authors.lastname: Moore
authors.affiliation: Vetnostics, Macquarie Park, NSW, Australia.
authors.forename: D P
authors.initials: DP
authors.lastname: Taylor
authors.affiliation: Vetnostics, Macquarie Park, NSW, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Reppas
authors.affiliation: Veterinary Oncology Consultants, 379 Lake Innes Drive, Wauchope, New South Wales, Australia.
authors.forename: A E
authors.initials: AE
authors.lastname: Frimberger
mesh_terms: D000818:Animals; D017024:Chemotherapy, Adjuvant / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D054747:Histiocytic Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D013534:Survival; D016019:Survival Analysis
keywords: cancer; chemotherapy; dogs; histiocytic sarcoma; oncology