title: A genetic risk factor for major depression and suicidal ideation is mitigated by physical activity.
abstract: We evaluated associations of five candidate polymorphisms (Bcl1 [rs41423247], -2C/G [rs2070951], COMT [rs737865], Val66Met [rs6265], and 5HTTLPR [biallelic and triallelic [5HTTLPR/rs25531]) with probable MDD and suicidal ideation (SI), the effects of physical activity on these endpoints, and whether physical activity attenuates genetic risk in military members (N=736). C carriers who were also less physically active were 3.3 times as likely to meet criteria for probable MDD and 9.6 times as likely to endorse SI as compared to physically active GG carriers. An adequate dose of physical activity diminishes risk of MDD and SI imposed by a genetic predisposition.
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, USA; School of Exercise and Nutritional Sciences, San Diego State University, ENS Building, Room 351, 5500 Campanile Drive, San Diego, CA 92182, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California, USA, Irvine, CA 92697, USA. Electronic address: marcus.k.taylor2.civ@mail.mil.
authors.forename: Marcus K
authors.initials: MK
authors.lastname: Taylor
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, USA.
authors.forename: Shiloh E
authors.initials: SE
authors.lastname: Beckerley
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, USA.
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Henniger
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, USA; School of Exercise and Nutritional Sciences, San Diego State University, ENS Building, Room 351, 5500 Campanile Drive, San Diego, CA 92182, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Hernández
authors.affiliation: Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, USA.
authors.forename: Gerald E
authors.initials: GE
authors.lastname: Larson
authors.affiliation: Institute for Interdisciplinary Salivary Bioscience Research, University of California, USA, Irvine, CA 92697, USA; Johns Hopkins University School of Nursing, and Johns Hopkins University Bloomberg School of Public Health, 3400 North Charles Street, Baltimore, MD 21218, USA.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Granger
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000235:genetics* / Q000517:prevention & control / Q000523:psychology; D015444:Exercise / Q000502:physiology* / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D040242:Risk Reduction Behavior; D059020:Suicidal Ideation
keywords: Exercise; Polymorphism; Suicide