title: Functional properties of dually modified sago starch/κ-carrageenan films: An alternative to gelatin in pharmaceutical capsules.
abstract: The aim of this study was development a composite film based on sago starch and κ-carrageenan to find a gelatin alternative in the pharmaceutical capsules processing. Hydrolyzed-Hydroxypropylated (dually modified) sago starch was mixed with κ-carrageenan (0.25, 0.5, 0.75, and 1%). The drying kinetics, thermomechanical, physicochemical, and barrier properties of composite films were estimated and compared with bovine gelatin. Results show that drying kinetics and mechanical properties of the composite films were comparable to those of gelatin. The water vapor permeability and moisture content of the composite films were lower than those of gelatin. The solubility of the composite films was higher than that of gelatin, and the composite films were more stable at higher relative humidity than were the gelatin films. These results show that dually modified sago starch in combination with κ-carrageenan has properties similar to those of gelatin, thus proposed system can be used in pharmaceutical capsules processes.
authors.affiliation: Department of Chemical Engineering, Shahrood Branch, Islamic Azad University, Shahrood, Iran.
authors.forename: Nazila
authors.initials: N
authors.lastname: Oladzadabbasabadi
authors.affiliation: Food Science and Technology Department, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Ebadi
authors.affiliation: Young Researchers and Elite Club, Damghan Branch, Islamic Azad University, Damghan, Iran. Electronic address: fstiau@gmail.com.
authors.forename: Abdorreza
authors.initials: A
authors.lastname: Mohammadi Nafchi
authors.affiliation: Food Biopolymer Research Group, Food Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
authors.forename: A A
authors.initials: AA
authors.lastname: Karim
authors.affiliation: Young Researchers and Elite Club, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Seyed Rahim
authors.initials: SR
authors.lastname: Kiahosseini
mesh_terms: D000818:Animals; D002214:Capsules; D002351:Carrageenan / Q000737:chemistry*; D002417:Cattle; D002626:Chemistry, Pharmaceutical; D005780:Gelatin / Q000737:chemistry; D010539:Permeability; D012995:Solubility; D013213:Starch / Q000737:chemistry*
chemical_list: D002214:Capsules; D002351:Carrageenan; D005780:Gelatin; D013213:Starch
keywords: Bovine gelatin; Drying kinetics; Dually modified starch; Mechanical properties; Water vapor permeability