title: Amygdala-prefrontal cortex resting-state functional connectivity varies with first depressive or manic episode in bipolar disorder.
abstract: Bipolar disorder (BD) is one of the most complex mental illnesses, characterized by interactive depressive and manic states that are 2 contrary symptoms of disease states. The bilateral amygdala and prefrontal cortex (PFC) appear to play critical roles in BD; however, abnormalities seem to manifest differently in the 2 states and may provide further insight into underlying mechanisms.
  
  
  
  Sixteen participants with first-episode depressive and 13 participants with first-episode manic states of bipolar disorder as well as 30 healthy control (HC) participants underwent resting-state functional magnetic resonance imaging (fMRI). Resting-state functional connectivity (rsFC) between the bilateral amygdala and PFC was compared among the 3 groups.
  
  
  
  Compared with depressive state participants of the BD group, manic state participants of the BD group showed a significant decrease in rsFC between the amygdala and right orbital frontal cortex (p<0.05, corrected). In addition, rsFC between the amygdala and left middle frontal cortex was significantly decreased in depressive and manic state participants of the BD group when compared with the HC group (p<0.05, corrected).
  
  
  
  Our findings suggest that mood state during the first episodes of BD may be related to abnormality in hemispheric lateralization. The abnormalities in amygdala- left PFC functional connectivity might present the trait feature for BD, while deficits in amygdala- right PFC functional connectivity might be specific to manic episode, compared to depressive episode.
authors.affiliation: Brain Function Research Section, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; Department of Radiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Wei
authors.affiliation: Department of Radiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Geng
authors.affiliation: Brain Function Research Section, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; Department of Radiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Radiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Miao
authors.initials: M
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; Department of Geriatric Medicine, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Yifang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Radiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Brain Function Research Section, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; Department of Geriatric Medicine, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Brain Function Research Section, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; Department of Radiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China; Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China. Electronic address: fei.wang@cmu.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D001714:Bipolar Disorder / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology*; D055815:Young Adult
keywords: Amygdala; Depressive; First episode; Functional connectivity; Manic; Prefrontal cortex; Resting state