title: Greater Adherence to Cancer Prevention Guidelines Is Associated with Higher Circulating Concentrations of Vitamin D Metabolites in a Cross-Sectional Analysis of Pooled Participants from 2 Chemoprevention Trials.
abstract: Background:Several lifestyle factors targeted by the American Cancer Society (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines are also associated with circulating concentrations of vitamin D metabolites. This suggests that greater adherence to the ACS guidelines may be related to better vitamin D status.Objective:We examined the relation between adherence to the ACS guidelines and circulating concentrations of 2 vitamin D metabolites, 25-hydroxycholecalciferol [25(OH)D] and 1α,25-dihydroxyvitamin D [1,25(OH)2D].Methods:We conducted cross-sectional analyses of pooled participants from the Wheat Bran Fiber (n= 503) and Ursodeoxycholic Acid (n= 854) trials. A cumulative adherence score was constructed with the use of baseline data on body size, diet, physical activity, and alcohol consumption. Continuous vitamin D metabolite concentrations and clinically relevant categories were evaluated with the use of multiple linear and logistic regression models, respectively.Results:The most adherent participants were more likely to be older, white, and nonsmokers than were the least adherent. A statistically significant association was observed between guideline adherence and concentrations of circulating 25(OH)D (means ± SEs-high adherence: 32.0 ± 0.8 ng/mL; low adherence: 26.4 ± 0.7 ng/mL;P-trend < 0.001). For 1,25(OH)2D concentrations, high adherence was again significantly related to greater metabolite concentrations, with mean ± SE concentrations of 36.3 ± 1.3 pg/mL and 31.9 ± 1.0 pg/mL for high- and low-adherers, respectively (P-trend = 0.008). Furthermore, the odds of attaining a sufficient 25(OH)D status were 4.37 times higher for those most adherent than for those least adherent (95% CI: 2.47, 7.71 times).Conclusion:These findings demonstrate that greater adherence to the ACS guidelines is associated with higher circulating concentrations of both of 25(OH)D and 1,25(OH)2D.
authors.affiliation: Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, and.
authors.forename: Lindsay N
authors.initials: LN
authors.lastname: Kohler
authors.affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Hibler
authors.affiliation: Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, and.|University of Arizona Cancer Center, Tucson, AZ.
authors.forename: Robin B
authors.initials: RB
authors.lastname: Harris
authors.affiliation: Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, and.
authors.forename: Eyal
authors.initials: E
authors.lastname: Oren
authors.affiliation: Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, and.|University of Arizona Cancer Center, Tucson, AZ.
authors.forename: Denise J
authors.initials: DJ
authors.lastname: Roe
authors.affiliation: School of Mathematical and Natural Sciences, Arizona State University, Phoenix, AZ; and.|Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Jurutka
authors.affiliation: Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, and jacobse@email.arizona.edu.|Department of Nutritional Sciences, University of Arizona, Tucson, AZ.|University of Arizona Cancer Center, Tucson, AZ.
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Jacobs
mesh_terms: D000236:Adenoma / Q000517:prevention & control; D000368:Aged; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D004043:Dietary Fiber; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D004043:Dietary Fiber; D014807:Vitamin D; D014580:Ursodeoxycholic Acid; C104450:25-hydroxyvitamin D
keywords: adherence; cancer prevention guidelines; diet; physical activity; vitamin D