title: Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10.
abstract: In the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While collectively called regulatory B cells (Breg), no definitive phenotype has emerged for B cells with regulatory potential. This has made their study challenging and thus unique B cell regulatory mechanisms have emerged in a disease-dependent manner. Thus to harness the therapeutic potential of Breg, further studies are needed to understand how they emerge and are induced to evoke their regulatory activities.
authors.affiliation: Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA. rayavijit@gmail.com.|Oncology Discovery, AbbVie Inc., North Chicago, IL 60064, USA. rayavijit@gmail.com.
authors.forename: Avijit
authors.initials: A
authors.lastname: Ray
authors.affiliation: Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA. bonnie.dittel@bcw.edu.|Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. bonnie.dittel@bcw.edu.
authors.forename: Bonnie N
authors.initials: BN
authors.lastname: Dittel
keywords: B cell; autoimmunity; immune regulation; inflammation