title: Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice.
abstract: Styphnolobium japonicum(L.) is utilized in Korean medicine for the treatment of various inflammatory diseases. The aim of the present study was to explore the effects of Fructus sophorae extract (FSE) isolated from the dried ripe fruit ofS. japonicum(L.) on the development of type II collagen-induced arthritis (CIA) in BALB/c mice. The CIA mice were orally administered FSE or saline daily for 2 weeks. The incidence and severity of disease and the inflammatory response in the serum and the joint tissues were assessed. Macroscopic and histological investigation indicated that FSE protected against CIA development. FSE was associated with a significant reduction in the levels of total immunoglobulin G2a and proinflammatory cytokines and mediators in the serum. In addition, FSE suppressed the gene expression levels of proinflammatory cytokines and mediators, the mediator of osteoclastic bone remodeling, the receptor activator of nuclear factor κ-B ligand and matrix metalloproteinases in the joint tissues. The present results suggest that FSE may protect against inflammation and bone damage, and would be a valuable candidate for further investigation as a novel anti-arthritic agent.
authors.affiliation: Department of Physiology, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.
authors.forename: Hyoung-Min
authors.initials: HM
authors.lastname: Han
authors.affiliation: Department of Biochemistry, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Hong
authors.affiliation: NOVAREX Co., Ltd. Life Science R&D Institute, Ochang, Chungcheongbuk 363-885, Republic of Korea.
authors.forename: Heung-Sik
authors.initials: HS
authors.lastname: Park
authors.affiliation: NOVAREX Co., Ltd. Life Science R&D Institute, Ochang, Chungcheongbuk 363-885, Republic of Korea.
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Jung
authors.affiliation: Department of Anatomy, College of Medicine, Kosin University, Busan 602-703, Republic of Korea.
authors.forename: Jong-Sik
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.
authors.forename: Yong-Tae
authors.initials: YT
authors.lastname: Lee
authors.affiliation: Anti-Aging Research Center and Blue-Bio Industry RIC, Dongeui University, Busan 614-714, Republic of Korea; Departments of Life Science and Biotechnology, Dongeui University, Busan 614-714, Republic of Korea.
authors.forename: Eun-Woo
authors.initials: EW
authors.lastname: Lee
authors.affiliation: Department of Biochemistry, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea; Anti-Aging Research Center and Blue-Bio Industry RIC, Dongeui University, Busan 614-714, Republic of Korea.
authors.forename: Yung-Hyun
authors.initials: YH
authors.lastname: Choi
authors.affiliation: Anti-Aging Research Center and Blue-Bio Industry RIC, Dongeui University, Busan 614-714, Republic of Korea; Departments of Life Science and Biotechnology, Dongeui University, Busan 614-714, Republic of Korea.
authors.forename: Byung-Woo
authors.initials: BW
authors.lastname: Kim
authors.affiliation: Research Center for Anti-Aging Technology Development, Busan 609-735, Republic of Korea; Department of Biochemistry, College of Medicine, Pusan National University, Yangsan, Gyeongsangnam 626-870, Republic of Korea.
authors.forename: Cheol-Min
authors.initials: CM
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.
authors.forename: Kyung-Hwa
authors.initials: KH
authors.lastname: Kang
keywords: Fructus sophorae extract; Styphnolobium japonicum L.; type II collagen-induced arthritis