title: Synthesis of fused indoline heterocycles via dearomatization of indoles with α-bromohydrazones: a systematic study on the substrates.
abstract: An efficient metal-free dearomatization of indoles with α-bromohydrazones is reported. Various fused indoline heterocycles, which are potentially biologically active, were achieved in good yields (up to 94%) under mild conditions. A systematic study on electronic- and steric effects of substrate and reagents revealed that they have great influence upon the reaction. Based on this, the scope of indoles and α-bromohydrazones was widely exploited.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, People's Republic of China. xuxp@suda.edu.cn shunjun@suda.edu.cn.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Cao
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji