title: Lipidomic and Antioxidant Response to Grape Seed, Corn and Coconut Oils in Healthy Wistar Rats.
abstract: Specialty oils differ in fatty acid, phytosterol and antioxidant content, impacting their benefits for cardiovascular health. The lipid (fatty acid, phytosterol) and antioxidant (total phenolics, radical scavenging capacity) profiles of grapeseed (GSO), corn (CO) and coconut (CNO) oils and their physiological (triacylglycerides, total and HDL-cholesterol and antioxidant capacity (FRAP) in serum and fatty acid and phytosterol hepatic deposition) and genomic (HL, LCAT, ApoA-1 and SR-BP1 mRNA hepatic levels) responses after their sub-chronic intake (10% diet for 28 days) was examined in healthy albino rats. Fatty acid, phytosterol and antioxidant profiles differed between oils (p≤ 0.01). Serum and hepatic triacylglycerides and total cholesterol increased (p≤ 0.01); serum HDL-Cholesterol decreased (p< 0.05); but serum FRAP did not differ (p> 0.05) in CNO-fed rats as compared to CO or GSO groups. Hepatic phytosterol deposition was higher (+2.2 mg/g;p≤ 0.001) in CO- than GSO-fed rats, but their fatty acid deposition was similar. All but ApoA-1 mRNA level increased in GSO-fed rats as compared to other groups (p≤ 0.01). Hepatic fatty acid handling, but not antioxidant response, nor hepatic phytosterol deposition, could be related to a more efficient reverse-cholesterol transport in GSO-fed rats as compared to CO or CNO.
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico. awall@uacj.mx.
authors.forename: Abraham
authors.initials: A
authors.lastname: Wall-Medrano
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico. ldelaros@uacj.mx.
authors.forename: Laura A
authors.initials: LA
authors.lastname: de la Rosa
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico. alma.vazquez@uacj.mx.
authors.forename: Alma A
authors.initials: AA
authors.lastname: Vázquez-Flores
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico. gil_4783@yahoo.com.mx.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Mercado-Mercado
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico. rga.nut@gmail.com.
authors.forename: Rogelio
authors.initials: R
authors.lastname: González-Arellanes
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico. joslopez@uacj.mx.
authors.forename: José A
authors.initials: JA
authors.lastname: López-Díaz
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, AC (Unidad Hermosillo), Coordinación de Tecnología de Alimentos de Origen Animal (DTAOA), Carretera a la Victoria km. 0.6, AP 1735, Hermosillo 83000, Sonora, Mexico. aaronglz@ciad.mx.
authors.forename: Aarón F
authors.initials: AF
authors.lastname: González-Córdova
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, AC (Unidad Hermosillo), Tecnología de Alimentos de Origen Vegetal (DTAOV), Carretera a la Victoria km. 0.6, AP 1735, Hermosillo 83000, Sonora, Mexico. gustavo@ciad.mx.
authors.forename: Gustavo A
authors.initials: GA
authors.lastname: González-Aguilar
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, AC (Unidad Hermosillo), Coordinación de Tecnología de Alimentos de Origen Animal (DTAOA), Carretera a la Victoria km. 0.6, AP 1735, Hermosillo 83000, Sonora, Mexico. vallejo@ciad.mx.
authors.forename: Belinda
authors.initials: B
authors.lastname: Vallejo-Cordoba
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, AC. (Unidad Cuauhtémoc), Laboratorio de Tecnología de Alimentos de Origen Vegetal y Toxicología, Ave. Río Conchos s/n, Parque Industrial, AP 781, Cuauhtémoc 31570, Chihuahua, Mexico. javiermolina@ciad.mx.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Molina-Corral
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000009:adverse effects / Q000032:analysis / Q000737:chemistry / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL / Q000819:agonists / Q000037:antagonists & inhibitors / Q000097:blood; D000074263:Coconut Oil; D003314:Corn Oil / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects / Q000627:therapeutic use*; D005227:Fatty Acids / Q000009:adverse effects / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use; D005786:Gene Expression Regulation; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D000072257:Oxygen Radical Absorbance Capacity; D010636:Phenols / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use; D010840:Phytosterols / Q000009:adverse effects / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use; D010938:Plant Oils / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D011897:Random Allocation; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D013047:Specific Pathogen-Free Organisms; D027843:Vitis / Q000737:chemistry
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008076:Cholesterol, HDL; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D010636:Phenols; D010840:Phytosterols; D010938:Plant Oils; D003314:Corn Oil; D000074263:Coconut Oil
keywords: HDL; antioxidant; coconut oil; corn oil; fatty acids; grapeseed oil; lipoproteins; phytosterols; specialty oil