title: Handheld Capillary Blood Lactate Analyzer as an Accessible and Cost-Effective Prognostic Tool for the Assessment of Death and Heart Failure Occurrence during Long-Term Follow-Up.
abstract: Impact of tissue lactate accumulation on prognosis after acute myocardial infarction (AMI) is biased. The study aimed to assess the prognostic role of lactate concentration (LC) in patients with AMI during one year of follow-up. 145 consecutive patients admitted due to AMI were enrolled. The data on the frequency of endpoint occurrence (defined as I, death; II, heart failure (HF); and III, recurrent myocardial infarction (re-MI)) were collected. The patients were divided into group A (LC below the cut-off value) and group B (LC above the cut-off value) for the endpoints according to receiver operating characteristic (ROC) analysis. The cumulative survival rate was 99% in group I-A and 85% in group I-B (p= 0.0004, log-rank test). The HF-free survival rate was 95% in group II-A and 82% in group II-B (p= 0.0095, log-rank test). The re-MI-free survival rate did not differ between groups. A multivariate Cox analysis showed a statistically significant influence of LC on death [Hazard Ratio (HR): 1.41, 95% Confidence Interval (CI) (1.13-1.76), andp= 0.002] and HF [HR: 1.21, 95% CI (1.05-1.4), andp= 0.007] with no impact on re-MI occurrence. LC in capillary blood may be considered a useful prognostic marker of late-onset heart failure and death after AMI.
authors.affiliation: Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland; Internal Medicine Department, Pyskowice Municipal Hospital, 2 Szpitalna Street, 44-120 Pyskowice, Poland.
authors.forename: Grzegorz M
authors.identifier: 0000-0001-6274-5831
authors.initials: GM
authors.lastname: Kubiak
authors.affiliation: Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland; 2nd Department of Cardiology in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Jacheć
authors.affiliation: Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland; 2nd Department of Cardiology in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Celina
authors.identifier: 0000-0003-3700-8439
authors.initials: C
authors.lastname: Wojciechowska
authors.affiliation: Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland; Internal Medicine Department, Pyskowice Municipal Hospital, 2 Szpitalna Street, 44-120 Pyskowice, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Traczewska
authors.affiliation: Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kolaszko
authors.affiliation: Internal Medicine Department, Pyskowice Municipal Hospital, 2 Szpitalna Street, 44-120 Pyskowice, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Kubiak
authors.affiliation: Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jojko
authors.affiliation: Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland; 2nd Department of Cardiology in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Nowalany-Kozielska
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood*; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D003362:Cost-Benefit Analysis; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000191:economics* / Q000209:etiology / Q000401:mortality*; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D007773:Lactates