title: TGF-β Family Signaling inDrosophila.
abstract: The transforming growth factor β (TGF-β) family signaling pathway is conserved and ubiquitous in animals. InDrosophila, fewer representatives of each signaling component are present compared with vertebrates, simplifying mechanistic study of the pathway. Although there are fewer family members, the TGF-β family pathway still regulates multiple and diverse functions inDrosophila.In this review, we focus our attention on several of the classic and best-studied functions for TGF-β family signaling in regulatingDrosophiladevelopmental processes such as embryonic and imaginal disc patterning, but we also describe several recently discovered roles in regulating hormonal, physiological, neuronal, innate immunity, and tissue homeostatic processes.
authors.affiliation: Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Ambuj
authors.initials: A
authors.lastname: Upadhyay
authors.affiliation: Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Moss-Taylor
authors.affiliation: Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Myung-Jun
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Arpan C
authors.initials: AC
authors.lastname: Ghosh
authors.affiliation: Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Michael B
authors.initials: MB
authors.lastname: O'Connor
mesh_terms: D000818:Animals; D019521:Body Patterning; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology; D004330:Drosophila / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D060227:Imaginal Discs / Q000166:cytology / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008958:Models, Molecular; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta