title: Assessing the level of matrix metal proteinases 1,8,9, their tissue inhibitor, type I, in cases of odontogenic phlegmons.
abstract: The article considers the measured values of the level of MMP-1, MMP-8 and MMP-9, and of their tissue inhibitor Type I (TIMP-1) in the blood serum and mixed saliva samples of 78 patients (31 women - 36.2 %, 47 men - 63.8 %) suffering from odontogenic phlegmons in the oral and maxillofacial region. The study indicators were assessed through the enzyme-linked immunosorbent assay using diagnostic sets RandD Diagnostics Inc. (USA). An uncontrolled hyperactivation of metal proteinases as one of the components of the systemic inflammatory response in case of phlegmon-related complications in the oral and maxillofacial region, as well as development of the sepsis syndrome were studied and it was determined that it results in distortion of the processes of reparative hystogeny and compel us to employ new approaches to the treatment of this type of patients (Tab. 2, Fig. 1, Ref. 13).
authors.forename: E V
authors.initials: EV
authors.lastname: Markelova
authors.forename: A L
authors.initials: AL
authors.lastname: Romanchuk
authors.forename: E V
authors.initials: EV
authors.lastname: Prosekova
authors.forename: V E
authors.initials: VE
authors.lastname: Krasnikov
authors.forename: S N
authors.initials: SN
authors.lastname: Beniova
mesh_terms: D000328:Adult; D002481:Cellulitis / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D020784:Matrix Metalloproteinase 8 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D010522:Periostitis / Q000473:pathology*; D011379:Prognosis; D012463:Saliva / Q000737:chemistry*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C488762:MMP8 protein, human; D020784:Matrix Metalloproteinase 8; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
keywords: metal proteinases; tissue inhibitor of metal proteinases odontogenic phlegmons.