title: [Mitofusin 2 and mitochondrial dynamics in norm and pathology].
abstract: Results of an intensive research performed during last 25 years have revealed that an understanding of biochemical and molecular principles of oxidative phosphorylation has not finished the streak of ground-breaking discoveries of newly identified mitochondrial functions in numerous cellular processes. Among other things it has been shown that mitochondria undergo reversible fission and fusion processes, and may form a complex network which functionally and structurally interacts with the endoplasmic reticulum membranes and probably also other organelles. An organization of mitochondrial network is closely controlled and is of high importance for numerous intracellular processes to occur properly. In this review, mitofusin 2 - one of a few proteins involved in a maintenance of an appropriate mitochondrial architecture, and in the consequence in the regulation of mitochondrial metabolism and calcium signalling, the controlling of the mitochondrial DNA level, and the regulation of cell proliferation and differentiation is the focus. Mutations within mitofusin 2-encoding gene are a cause of Charcot-Marie-Tooh 2A - type neuropathies while an affected expression of this protein seems to be related to neoplasia, type 2 diabetes, or vascular hyperplasia. Numerous experimental data confirm pleiotropic effects of mitofisin 2 in animal cells.
authors.affiliation: Molecular Biology Unit, Mossakowski Medical Research Centre, PAS, 5 A. Pawińskiego St., 02-106 Warsw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Kawalec
authors.affiliation: Molecular Biology Unit, Mossakowski Medical Research Centre, PAS, 5 A. Pawińskiego St., 02-106 Warsw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Beręsewicz
authors.affiliation: Cell Metabolism Laboratory, Nencki Institute of Experimental Biology, PAS, 3 Pasteura St., 02-093 Warsaw, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zabłocki
authors.affiliation: Molecular Biology Unit, Mossakowski Medical Research Centre, PAS, 5 A. Pawińskiego St., 02-106 Warsw, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Zabłocka
mesh_terms: D002118:Calcium / Q000378:metabolism; D049109:Cell Proliferation; D004272:DNA, Mitochondrial; D020558:GTP Phosphohydrolases / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000502:physiology*
chemical_list: D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; C470018:MFN2 protein, human; C488751:Mfn2 protein, mouse; D002118:Calcium
keywords: Mitofusin 2; mitochondria; mitochondrial network