title: Treatment of Pelvic Floor Disorders Following Neobladder.
abstract: Radical cystectomy remains the gold standard treatment for organ-confined high-grade recurrent or muscle-invasive bladder cancer. Orthotopic neobladder urinary diversion following cystectomy represents an option for patients wishing for continent urinary diversion. Female patients who undergo radical cystectomy with orthotopic bladder substitution are at risk for developing both common and neobladder-specific disorders of the pelvic floor, including urinary incontinence, hypercontinence, vaginal prolapse, and neobladder-vaginal fistula. Each of these sequelae can have significant impact on the patient's quality of life. Due to the increased frequency of orthotopic neobladder creation in women, subspecialty urologists are more likely to confront such pelvic floor disorders in bladder cancer survivors. This review presents the most current information on the treatment of pelvic floor disorders after orthotopic bladder substitution.
authors.affiliation: Department of Urology, University of Arkansas Medical Center, 4301 W. Markham St, Slot 540, Little Rock, AR, 72201, USA. nrlittlejohn@uams.edu.
authors.forename: Nathan
authors.initials: N
authors.lastname: Littlejohn
authors.affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Cohn
authors.affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Casey G
authors.initials: CG
authors.lastname: Kowalik
authors.affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Kaufman
authors.affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Roger R
authors.initials: RR
authors.lastname: Dmochowski
authors.affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: W Stuart
authors.initials: WS
authors.lastname: Reynolds
mesh_terms: D015653:Cystectomy; D005402:Fistula / Q000150:complications; D006801:Humans; D059952:Pelvic Floor Disorders / Q000209:etiology / Q000628:therapy*; D011788:Quality of Life; D001745:Urinary Bladder Diseases / Q000150:complications
keywords: Cystectomy; Fistula; Incontinence; Neobladder; Prolapse; Urinary retention