title: Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging.
abstract: Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs) communicate with organ systems to adjust immune response, provide signals for differentiation, migration, enzymatic reactions, and to equilibrate the regenerative demands of balanced tissue homeostasis. The identification of the mechanisms by which ADSCs accomplish these functions for dermatological rejuvenation and wound healing has great potential to identify novel targets for the treatment of disorders and combat aging. Herein, we review new insights into the role of adipose-derived stem cells in the maintenance of dermal and epidermal homeostasis, and recent advances in clinical applications of ADSCs related to dermatology.
authors.affiliation: Aelan Cell Technology, San Francisco, CA 94107, USA. mgaur@aelanct.com.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Gaur
authors.affiliation: Division of Plastic Surgery, University of California, San Diego, La Jolla, CA 92121, USA. mdobke@ucsd.edu.
authors.forename: Marek
authors.initials: M
authors.lastname: Dobke
authors.affiliation: Aelan Cell Technology, San Francisco, CA 94107, USA. vlunyak@aelanct.com.
authors.forename: Victoria V
authors.initials: VV
authors.lastname: Lunyak
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D012060:Rejuvenation / Q000502:physiology; D015595:Skin Aging / Q000502:physiology*; D012871:Skin Diseases / Q000503:physiopathology* / Q000628:therapy; D014945:Wound Healing / Q000502:physiology*
keywords: adipose-derived stem cells; aging; clinical applications; dermis; epidermis; matrikines; skin homeostasis; subcutaneous adipose depot; wound healing