title: Amplified Photodegradation of Cell-Laden Hydrogels via an Addition-Fragmentation Chain Transfer Reaction.
abstract: Hydrogels crosslinked by allyl-sulfide-containing molecules are presented. By exposure to light in the presence of a photoinitiator and a free monofunctional thiol, photodegradation is achieved. Both the gelation and degradation are cytocompatible and allow for cell encapsulation and subsequent release. The photodegradation kinetics and depths attainable are superior to those of traditional cell-laden photodegradable hydrogels.
authors.affiliation: Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
authors.forename: Tobin E
authors.initials: TE
authors.lastname: Brown
authors.affiliation: Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Marozas
authors.affiliation: Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.|Howard Hughes Medical Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
authors.forename: Kristi S
authors.initials: KS
authors.lastname: Anseth
keywords: AFCT; adaptable networks; hydrogels; photodegradation; thiol-ene