title: [A Case of a Large Gastric Gastrointestinal Stromal Tumor with a PDGFRA Exon 18 Mutation].
abstract: A 49-year-old man visited our hospital with a chief complaint of abdominal pain that began 1 day before his visit.An approximately 30 cm tumor that was extensively in contact with the gastric wall in the abdominal cavity was detected on computed tomography(CT).An elevated lesion covered with normal mucosa on the posterior wall of the greater curvature was detected on upper endoscopy.He was diagnosed with a submucosal tumor of the stomach, and he underwent surgery. Surgical findings revealed an elastic soft tumor with a maximal dimension of 38 cm that projected from the posterior wall of the stomach beyond the gastric wall.No invasion and metastasis to other organs were detected.Partial gastrectomy was performed.On histopathological examination, proliferation of atypical round and spindle cells was found, and immunostaining was negative for KIT but positive for CD34.In the gene search, an Asp842Val mutation was detected in exon 18 of the PDGFRA gene.Currently, the patient has survived for 7 months after surgery without recurrence.
authors.affiliation: Dept. of Surgery, Bell Land General Hospital.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Imagawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Tomizawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okumura
authors.forename: Sho
authors.initials: S
authors.lastname: Toyoda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Kansuke
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Aya
authors.initials: A
authors.lastname: Ito
authors.forename: Naoto
authors.initials: N
authors.lastname: Mizumura
authors.forename: Ken
authors.initials: K
authors.lastname: Yoo
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Maehira
authors.forename: Masao
authors.initials: M
authors.lastname: Ogawa
authors.forename: Masayasu
authors.initials: M
authors.lastname: Kawasaki
authors.forename: Masao
authors.initials: M
authors.lastname: Kameyama
authors.forename: Michiko
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirota
mesh_terms: D005091:Exons; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000601:surgery
chemical_list: D020796:Receptor, Platelet-Derived Growth Factor alpha