title: The effect of mad honey on testosterone levels of male rats.
abstract: We aimed to investigate the effect of mad honey on sexual performance.
  
  
  
  In traditional medicine in Turkey, mad honey is used to improve appetite, to heighten mental alertness, to reduce joint pain, to eliminate gastrointestinal system pains and to increase sexual performance.
  
  
  
  In this experimental animal study eighteen Sprague Dawley male rats were randomized into three groups, a control group, a normal honey group and a mad honey group. Rats in the treatment groups were given a daily dose of 80 mg/kg normal honey or mad honey throughout the 30-day study period. Total testosterone, free testosterone, FSH, LH, estradiol, and progesterone levels were subsequently investigated from blood sera on day 30.
  
  
  
  Comparison of blood total testosterone levels among the groups revealed significantly higher levels in the mad honey group compared to the normal honey and control groups (p = 0.006, p = 0.00). Free testosterone levels were also significantly higher in the mad honey group than in the normal honey and control groups (p = 0.023, p = 0.01). No statistically significant differences were determined for other hormonal measurements.
  
  
  
  This study revealed a significant increase in both total and free testosterone levels in mad-honey group (Tab. 1, Fig. 2, Ref. 16).
authors.forename: O
authors.initials: O
authors.lastname: Tatli
authors.forename: Y
authors.initials: Y
authors.lastname: Karaca
authors.forename: S
authors.initials: S
authors.lastname: Turkmen
authors.forename: G S
authors.initials: GS
authors.lastname: Gulgen
authors.forename: A
authors.initials: A
authors.lastname: Sahin
authors.forename: U
authors.initials: U
authors.lastname: Eryigit
authors.forename: O
authors.initials: O
authors.lastname: Fazli
authors.forename: E
authors.initials: E
authors.lastname: Karaguzel
authors.forename: A
authors.initials: A
authors.lastname: Mentese
authors.forename: A
authors.initials: A
authors.lastname: Orem
authors.forename: A
authors.initials: A
authors.lastname: Cansu
authors.forename: S
authors.initials: S
authors.lastname: Turedi
authors.forename: A
authors.initials: A
authors.lastname: Gunduz
mesh_terms: D000818:Animals; D005640:Follicle Stimulating Hormone / Q000097:blood; D006722:Honey / Q000009:adverse effects*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011374:Progesterone / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012725:Sexual Behavior; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: grayanotoxin; mad honey; sexual performance testosterone.; traditional medicine