title: Polymorphisms of Dopamine Receptor Genes and Risk of L-Dopa-Induced Dyskinesia in Parkinson's Disease.
abstract: L-dopa-induced dyskinesia (LID) is a frequent motor complication of Parkinson's disease (PD), associated with a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and LID, the results of which have not been confirmed. The present study is aimed to determine whether genetic differences ofDRare associated with LID in a small but well-characterized cohort of PD patients. To this end we enrolled 100 PD subjects, 50 with and 50 without LID, matched for age, gender, disease duration and dopaminergic medication in a case-control study. We conducted polymerase chain reaction for single nucleotide polymorphisms (SNP) in both D1-like (DRD1A48G;DRD1C62T andDRD5T798C) and D2-likeDR(DRD2G2137A,DRD2C957T,DRD3G25A,DRD3G712C,DRD4C616G andDRD4nR VNTR 48bp) analyzed genomic DNA. Our results showed that PD patients carrying allele A atDRD3G3127A had an increased risk of LID (OR 4.9; 95% CI 1.7-13.9;p= 0.004). The present findings may provide valuable information for personalizing pharmacological therapy in PD patients.
authors.affiliation: Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy. comi@med.uniupo.it.
authors.forename: Cristoforo
authors.initials: C
authors.lastname: Comi
authors.affiliation: Center of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy. marco.ferrari@uninsubria.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Ferrari
authors.affiliation: Center of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy. franca.marino@uninsubria.it.
authors.forename: Franca
authors.initials: F
authors.lastname: Marino
authors.affiliation: Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy. magis.luca@gmail.com.
authors.forename: Luca
authors.initials: L
authors.lastname: Magistrelli
authors.affiliation: Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy. cantello@med.uniupo.it.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cantello
authors.affiliation: Departments of Biotechnology and Life Science, University of Insubria, 21100 Varese, Italy. g.riboldazzi@fastwebnet.it.
authors.forename: Giulio
authors.initials: G
authors.lastname: Riboldazzi
authors.affiliation: Departments of Biotechnology and Life Science, University of Insubria, 21100 Varese, Italy. mlebianchi@hotmail.com.
authors.forename: Maria Laura Ester
authors.initials: ML
authors.lastname: Bianchi
authors.affiliation: Departments of Biotechnology and Life Science, University of Insubria, 21100 Varese, Italy. giorgio.bono@uninsubria.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bono
authors.affiliation: Center of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy. marco.cosentino@uninsubria.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Cosentino
mesh_terms: D000368:Aged; D000483:Alleles; D000818:Animals; D018450:Disease Progression; D020820:Dyskinesias / Q000209:etiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011954:Receptors, Dopamine / Q000235:genetics*
chemical_list: D011954:Receptors, Dopamine; D007980:Levodopa
keywords: Parkinson’s disease; SNPs; disease progression; motor complications; personalized medicine