title: Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis.
abstract: BACKGROUND
  Much of the attention of tuberculosis (TB) programs is focused on outcomes of microbiological cure and mortality, and health related quality of life (HRQL) is undervalued. Also, TB patients have a significantly higher risk of developing depression and anxiety compared with those in the general population. We intend to evaluate the HRQL and the prevalence of symptoms of depression and anxiety in hospitalized patients with TB.
  
  
  METHODS
  Cross-sectional study in a tertiary care hospital in Brazil. Adult patients with pulmonary TB that were hospitalized during the study period were identified and invited to participate. HRQL was measured using the Medical Outcomes Study Short Form-36 (SF-36) version 2. Hospital Anxiety and Depression Scale (HADS) was used to record symptoms of anxiety and depression.
  
  
  RESULTS
  Eighty-six patients were included in the analysis. The mean age of all patients was 44.6±15.4 years, 69.8% were male, and 53.5% were white. Thirty-two patients (37.2%) were human immunodeficiency virus positive. Twenty-seven patients (31.4%) met study criteria for depression (HADS depression score ≥11) and 33 (38.4%) had anxiety (HADS anxiety score ≥11). Scores on all domains of SF-36 were significantly lower than the Brazilian norm scores (p<0.001).
  
  
  CONCLUSIONS
  The present study shows that TB patients may have a poor HRQL. Additionally, we found a possible high prevalence of depression and anxiety in this population. Health care workers should be aware of these psychological disorders to enable a better management of these patients. The treatment of these comorbidities may be associated with better TB outcomes.
authors.affiliation: Graduate Program in Pneumological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Ana Paula Ceré
authors.initials: AP
authors.lastname: Dos Santos
authors.affiliation: Graduate Program in Pneumological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Tássia Kirchmann
authors.initials: TK
authors.lastname: Lazzari
authors.affiliation: Graduate Program in Pneumological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Pulmonology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Denise Rossato
authors.initials: DR
authors.lastname: Silva
keywords: Anxiety; Comorbidity; Depression; Mental Disorders; Mycobacterium tuberculosis; Quality of Life; Tuberculosis