title: Anastomosing hemangioma: report of two renal cases and analysis of the literature.
abstract: BACKGROUND
  Anastomosing hemangioma (AH) is a very rare vascular tumor mimicking angiosarcoma, predominately observed in kidney and less frequently in other organs. We present two new renal cases of AH at opposite ends of the clinical presentation spectrum, provide review of the literature and compare the epidemiological, clinical and pathological profiles of renal and non-renal cases.
  
  
  METHODS
  The first occurred in a 64-year-old woman presented with back pain and the second, a multifocal lesion, in a 47-year-old man with end stage renal disease (ESRD). Histology disclosed a vascular tumor with striking anastomosing pattern, minimal nuclear atypia and locally infiltrative pattern, mimicking superficially angiosarcoma. Extramedullary hematopoiesis, extensive perirenal fat entrapment and increased number of mast cells were additional features in the second lesion. Both patients are well, without disease, 25 and 14 months after diagnosis.
  
  
  CONCLUSIONS
  Comprehensive review and analysis of the published literature show that the growing number of non-renal AHs exhibits similar epidemiologic, clinical, biologic and histologic characteristics with renal AHs and most mild differences vanish after exclusion of cases associated with ESRD. Better understanding of AH pathogenesis will contribute to optimal treatment choices.
authors.affiliation: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Goudi, Mikras Asias 75, 11527, Athens, Greece.
authors.forename: Marina
authors.initials: M
authors.lastname: Perdiki
authors.affiliation: Department of Pathology, Medical School, University of Crete, Voutes, Heraklion, 71110, Greece.
authors.forename: Galateia
authors.initials: G
authors.lastname: Datseri
authors.affiliation: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Goudi, Mikras Asias 75, 11527, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Liapis
authors.affiliation: Department of Urology-University Hospital of Heraklion, Medical School, University of Crete, Voutes, Heraklion, 71110, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Chondros
authors.affiliation: First Department of Urology, Medical School, National and Kapodistrian University of Athens, Goudi, Mikras Asias 75, 11527, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Anastasiou
authors.affiliation: Department of Pathology, Medical School, University of Crete, Voutes, Heraklion, 71110, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Tzardi
authors.affiliation: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Goudi, Mikras Asias 75, 11527, Athens, Greece.
authors.forename: Johanna K
authors.initials: JK
authors.lastname: Delladetsima
authors.affiliation: Department of Pathology, Medical School, University of Crete, Voutes, Heraklion, 71110, Greece. drakil@uoc.gr.
authors.forename: Elias
authors.initials: E
authors.lastname: Drakos
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006391:Hemangioma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor
keywords: Anastomosing; Hemangioma; Non-renal; Renal; Review