title: The effects of hydroporation on melasma with anti-aging cocktail.
abstract: BACKGROUND
  Jet-M is a device for epidermal peeling and is used to deliver substances by spraying air and microdroplets. Previously, a case was treated with a mixed solution of copper-GHK, oligo-hyaluronic acid, Rhodiola extract, tranexamic acid, and β-glucan. The results showed significant improvement of aged skin.
  
  
  OBJECTIVE
  This study was conducted to evaluate the effects of hydroporation on melasma with the formulation in a small group of volunteers.
  
  
  METHODS
  Clinical effects were evaluated by both subjective and objective methods including melanin index (MI) and erythema index (EI) measurement.
  
  
  RESULTS
  Clinically, pigmentation and erythema were relieved and also both MI and EI decreased. Histopathologic observation revealed that type IV collagen and procollagen were increased in the upper dermis. Furthermore, the number of p63-positive cells is increased along the basement membrane. These results all suggest that hydroporation with GHR formulation induced anti-aging effects by reconstruction of extracellular matrix.
  
  
  CONCLUSIONS
  These findings suggest that the treatment may have depigmenting effects and erythema decreasing effects by enhancing the microenvironment of the skin.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.|Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
authors.forename: Je Byeong
authors.identifier: http://orcid.org/0000-0002-0968-3819
authors.initials: JB
authors.lastname: Chae
authors.affiliation: Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
authors.forename: Seung Hye
authors.initials: SH
authors.lastname: Yang
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.|Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
authors.forename: Sang Young
authors.initials: SY
authors.lastname: Byun
authors.affiliation: Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
authors.forename: Hye-Ryung
authors.initials: HR
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.|Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Shin
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.|Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
authors.forename: Kyoung-Chan
authors.initials: KC
authors.lastname: Park
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D024141:Collagen Type IV / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D004338:Drug Combinations; D004890:Erythema / Q000188:drug therapy; D005109:Extracellular Matrix / Q000187:drug effects; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D015603:Keratinocytes / Q000378:metabolism; D008548:Melanosis / Q000188:drug therapy* / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism; D009842:Oligopeptides / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D011347:Procollagen / Q000378:metabolism; D029771:Rhodiola; D012720:Severity of Illness Index; D014148:Tranexamic Acid / Q000627:therapeutic use*; D047071:beta-Glucans / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; C081876:CKAP4 protein, human; D024141:Collagen Type IV; D003879:Dermatologic Agents; D004338:Drug Combinations; D008565:Membrane Proteins; D009842:Oligopeptides; D010936:Plant Extracts; D011347:Procollagen; D047071:beta-Glucans; D014148:Tranexamic Acid; D003300:Copper; D006820:Hyaluronic Acid
keywords: Jet-M; basement membrane; collagen; hydroporation; melasma