title: In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism.
abstract: This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in mice for 30 days. ATP and neutrophil concentrations have been measured, at the implant site after the device was explanted, to assess the level of biocompatibility of the device. Finally, fully working prototypes of the device were implanted in mice and tested. The implanted devices were used to detect variations in the physiological concentrations of glucose and paracetamol. Data trends on these analytes have been successfully acquired and transmitted to the external base station. Glucose and paracetamol (also named acetaminophen) have been proposed in this research as model molecules for applications to personalized and translational medicine.
authors.forename: Camilla
authors.initials: C
authors.lastname: Baj-Rossi
authors.forename: Andrea
authors.initials: A
authors.lastname: Cavallini
authors.forename: Enver G
authors.initials: EG
authors.lastname: Kilinc
authors.forename: Francesca
authors.initials: F
authors.lastname: Stradolini
authors.forename: Tanja
authors.initials: T
authors.lastname: Rezzonico Jost
authors.forename: Michele
authors.initials: M
authors.lastname: Proietti
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Micheli
authors.forename: Fabio
authors.initials: F
authors.lastname: Grassi
authors.forename: Catherine
authors.initials: C
authors.lastname: Dehollain
authors.forename: Sandro
authors.initials: S
authors.lastname: Carrara
mesh_terms: D000082:Acetaminophen / Q000097:blood*; D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D001786:Blood Glucose / Q000032:analysis*; D003217:Conductometry / Q000295:instrumentation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008904:Miniaturization; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D019736:Prostheses and Implants; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D059015:Wireless Technology / Q000295:instrumentation*
chemical_list: D001786:Blood Glucose; D000082:Acetaminophen