title: Efficient preparation of 2-nitroimidazole nucleosides as precursors for hypoxia PET tracers.
abstract: 2-Deoxy-D-ribose was converted toα/β-mixtures of methyl 3-O-acetyl- and methyl 3-O-benzoyl-2-deoxy-5-(p-toluenesulfonyl)-D-ribofuranosides. These were reacted with boron trichloride to generate ribofuranosyl chlorides, which afforded precursors for tracers to image tumor hypoxia on substitution with salts of 2-nitroimidazole. The anomeric ratio of the nucleosides was delicately influenced by the reaction conditions.
authors.affiliation: Department of Organic Chemistry, University of Vienna, Vienna, Austria.
authors.forename: Petra
authors.initials: P
authors.lastname: Križková
authors.affiliation: Department of Organic Chemistry, University of Vienna, Vienna, Austria.
authors.forename: Anna
authors.initials: A
authors.lastname: Wieczorek
authors.affiliation: Department of Organic Chemistry, University of Vienna, Vienna, Austria.
authors.forename: Friedrich
authors.identifier: 0000-0003-2193-1405
authors.initials: F
authors.lastname: Hammerschmidt
keywords: 2-Deoxy-D-ribose nucleosides; 2-Nitroimidazole; Alkylation; Halogenides; Hypoxia