title: Sex Differences and Functional Outcome After Intravenous Thrombolysis.
abstract: Women have a worse outcome after stroke compared with men, although in intravenous thrombolysis (IVT)-treated patients, women seem to benefit more. Besides sex differences, age has also a possible effect on functional outcome. The interaction of sex on the functional outcome in IVT-treated patients in relation to age remains complex. The purpose of this study was to compare outcome after IVT between women and men with regard to age in a large multicenter European cohort reflecting daily clinical practice of acute stroke care.
  
  
  
  Data were obtained from IVT registries of 12 European tertiary hospitals. The primary outcome was poor functional outcome, defined as a modified Rankin scale score of 3 to 6 at 3 months. We stratified outcome by age in decades. Safety measures were symptomatic intracranial hemorrhage and mortality at 3 months.
  
  
  
  In this cohort, 9495 patients were treated with IVT, and 4170 (43.9%) were women with a mean age of 71.9 years. After adjustments for baseline differences, female sex remained associated with poor functional outcome (odds ratio, 1.15; 95% confidence interval, 1.02-1.31). There was no association between sex and functional outcome when data were stratified by age. Symptomatic intracranial hemorrhage rate was similar in both sexes (adjusted odds ratio, 0.93; 95% confidence interval, 0.73-1.19), whereas mortality was lower among women (adjusted odds ratio, 0.83; 95% confidence interval, 0.70-0.99).
  
  
  
  In this large cohort of IVT-treated patients, women more often had poor functional outcome compared with men. This difference was not dependent on age.
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Fianne H
authors.initials: FH
authors.lastname: Spaander
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Sanne M
authors.initials: SM
authors.lastname: Zinkstok
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Irem M
authors.initials: IM
authors.lastname: Baharoglu
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Henrik
authors.initials: H
authors.lastname: Gensicke
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Alexandros
authors.initials: A
authors.lastname: Polymeris
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Christopher
authors.initials: C
authors.lastname: Traenka
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Christian
authors.initials: C
authors.lastname: Hametner
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Peter
authors.initials: P
authors.lastname: Ringleb
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Sami
authors.initials: S
authors.lastname: Curtze
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Nicolas
authors.initials: N
authors.lastname: Martinez-Majander
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Karoliina
authors.initials: K
authors.lastname: Aarnio
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Christian H
authors.initials: CH
authors.lastname: Nolte
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Jan F
authors.initials: JF
authors.lastname: Scheitz
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Didier
authors.initials: D
authors.lastname: Leys
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Anais
authors.initials: A
authors.lastname: Hochart
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Visnja
authors.initials: V
authors.lastname: Padjen
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Georg
authors.initials: G
authors.lastname: Kägi
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pezzini
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Patrik
authors.initials: P
authors.lastname: Michel
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Olivier
authors.initials: O
authors.lastname: Bill
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Andrea
authors.initials: A
authors.lastname: Zini
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.).
authors.forename: Stefan T
authors.initials: ST
authors.lastname: Engelter
authors.affiliation: From the Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands (F.H.S., S.M.Z., I.M.B., P.J.N.); Stroke Center and Department of Neurology, University Hospital Basel, Switzerland (H.G., A.P., C.T., S.T.E.); Department of Neurology, University Hospital Heidelberg, Germany (C.H., P.R.); Department of Neurology, Helsinki University Central Hospital, Finland (S.C., N.M.-M., K.A.); Department of Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., J.F.S.); University Lille, Inserm, CHU Lille, U1171-Degenerative and Vascular Cognitive Disorders, France (D.L., A.H.); Department of Neurology, Clinical Centre of Serbia, Beograd (V.P.); Department of Neurology, Kantonsspital St. Gallen, Switzerland (G.K.); Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italy (A.P.); Department of Neurology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland (P.M., O.B.); and Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy (A.Z.). p.j.nederkoorn@amc.uva.nl.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Nederkoorn
mesh_terms: D061605:Administration, Intravenous / Q000379:methods; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: age distribution; female; registries; stroke; thrombolytic therapy