title: The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases.
abstract: The Metabolic Syndrome in Men (METSIM) study is a population-based study including 10,197 Finnish men examined in 2005-2010. The aim of the study is to investigate nongenetic and genetic factors associated with the risk of T2D and CVD, and with cardiovascular risk factors. The protocol includes a detailed phenotyping of the participants, an oral glucose tolerance test, fasting laboratory measurements including proton NMR measurements, mass spectometry metabolomics, adipose tissue biopsies from 1,400 participants, and a stool sample. In our ongoing follow-up study, we have, to date, reexamined 6,496 participants. Extensive genotyping and exome sequencing have been performed for essentially all METSIM participants, and >2,000 METSIM participants have been whole-genome sequenced. We have identified several nongenetic markers associated with the development of diabetes and cardiovascular events, and participated in several genetic association studies to identify gene variants associated with diabetes, hyperglycemia, and cardiovascular risk factors. The generation of a phenotype and genotype resource in the METSIM study allows us to proceed toward a "systems genetics" approach, which includes statistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein, or metabolite levels, to provide a global view of the molecular architecture of complex traits.
authors.affiliation: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland markku.laakso@uef.fi.|Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Laakso
authors.affiliation: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.|Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Kuusisto
authors.affiliation: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
authors.forename: Alena
authors.initials: A
authors.lastname: Stančáková
authors.affiliation: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
authors.forename: Teemu
authors.initials: T
authors.lastname: Kuulasmaa
authors.affiliation: Departments of Human Genetics David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA.|Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA.
authors.forename: Päivi
authors.initials: P
authors.lastname: Pajukanta
authors.affiliation: Departments of Human Genetics David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA.|Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA.
authors.forename: Aldons J
authors.initials: AJ
authors.lastname: Lusis
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
authors.forename: Francis S
authors.initials: FS
authors.lastname: Collins
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, NC.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Mohlke
authors.affiliation: Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.
authors.forename: Michael
authors.initials: M
authors.lastname: Boehnke
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000368:Aged; D001706:Biopsy; D001786:Blood Glucose; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D005951:Glucose Tolerance Test; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000235:genetics / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D055432:Metabolomics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D001786:Blood Glucose
keywords: METSIM; cardiovascular risk factors; coronary artery disease; metabolic disease; type 2 diabetes