title: Cardiovascular effects of fission neutron or60Co γ exposure in the B6CF1mouse.
abstract: In this study, the B6CF1mice from the JANUS program at the Argonne National Laboratory were analyzed for increased cardiovascular disease (CVD) mortality from60Co γ ray or fission neutron exposures administered in either a single dose or protracted weekly doses. The data used for this study represent the last studies conducted at Argonne and have been archived for at least 15 years. CVD mortality increased in a dose-dependent manner from γ rays as well as from neutron exposures. The relative biological effectiveness (RBE) for neutrons is about 4 or 5. CVD mortality appeared to be enhanced when the dose was protracted, with a DDREF (dose and dose rate effectiveness factor) in the range of 0.4-0.45 for neutron and gamma ray exposure, respectively.
authors.affiliation: a Department of Public Health Sciences , Medical University of South Carolina , Charleston , SC , USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Hoel
authors.affiliation: b The Donald W. Reynolds Department of Geriatric Medicine , University of Oklahoma College of Medicine , Oklahoma City , OK , USA.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Carnes
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006331:Heart Diseases / Q000401:mortality* / Q000473:pathology; D008297:Male; D051379:Mice; D009502:Neutrons; D009680:Nuclear Fission; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000706:statistics & numerical data*; D011832:Radiation Injuries / Q000401:mortality* / Q000473:pathology; D012062:Relative Biological Effectiveness; D015996:Survival Rate; D014916:Whole-Body Irradiation / Q000401:mortality*
chemical_list: D003037:Cobalt Radioisotopes
keywords: B6CF1; Cardiovascular; DDREF; RBE; gamma ray; neutron