title: Impact of dietary fat composition on prediabetes: a 12-year follow-up study.
abstract: OBJECTIVE
  Dietary fatty acid composition likely affects prediabetic conditions such as isolated impaired fasting glucose (IFG) or impaired glucose tolerance (IGT); however, this risk has not been evaluated in a large population nor has it been followed prospectively.
  
  
  METHODS
  Diet, physical activity, anthropometric, socio-economic and blood glucose data from the Atherosclerosis Risk in Communities (ARIC) study were obtained from BioLINCC. Cox proportional hazards regression models were used to evaluate associations of dietary SFA, MUFA, PUFA, n-3 fatty acid (FA) and n-6 FA intakes with incidence of one (isolated IFG) or two (IFG with IGT) prediabetic conditions at the end of 12-year follow-up.
  
  
  METHODS
  Study volunteers were from counties in North Carolina, Mississippi, Minnesota and Maryland, USA.
  
  
  METHODS
  Data from 5288 volunteers who participated in the ARIC study were used for all analyses reported herein.
  
  
  RESULTS
  The study population was 62% male and 84 % white, mean age 53·5 (sd 5·7) years and mean BMI 26·2 (sd 4·6) kg/m2. A moderately high intake of dietary MUFA (10-15 % of total daily energy) was associated with a 10 % reduced risk of isolated IFG incidence, while a high intake of n-3 FA (>0·15 % of total daily energy) was associated with a 10 % increase in risk. Curiously, moderately high intake of n-6 PUFA (4-5 % of total daily energy) was associated with a 12 % reduction in IFG and IGT incidence.
  
  
  CONCLUSIONS
  MUFA, n-3 and n-6 FA contribute differently to the development of isolated IFG v. IFG with IGT; and their mechanism may be more complex than originally proposed.
authors.affiliation: 1Department of Nutrition,University of California Davis,430 W. Health Sciences Drive,Davis,CA 95616,USA.
authors.forename: Sridevi
authors.initials: S
authors.lastname: Krishnan
authors.affiliation: 2Division of Epidemiology and Community Health,School of Public Health,University of Minnesota,Minneapolis,MN,USA.
authors.forename: Lyn M
authors.initials: LM
authors.lastname: Steffen
authors.affiliation: 3Department of Food Science and Technology,University of Georgia,Athens,GA,USA.
authors.forename: Chad M
authors.initials: CM
authors.lastname: Paton
authors.affiliation: 4Department of Foods and Nutrition,University of Georgia,Athens,GA,USA.
authors.forename: Jamie A
authors.initials: JA
authors.lastname: Cooper
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D015444:Exercise; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008396:Maryland; D008875:Middle Aged; D008910:Minnesota; D008922:Mississippi; D009657:North Carolina; D011236:Prediabetic State / Q000097:blood / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6
keywords: Impaired fasting glucose; Impaired glucose tolerance; MUFA; n-6