title: Dosimetric aspects of breast radiotherapy with three-dimensional and intensity-modulated radiotherapy helical tomotherapy planning modules.
abstract: In this work, we investigated the dosimetric differences between the intensity-modulated radiotherapy (IMRT) plans and the three-dimensional (3D) helical plans based on the TomoTherapy system. A total of 15 patients with supine setup were randomly selected from the data base. For patients with lumpectomy planning target volume (PTV), regional lymph nodes were also included as part of the target. For dose sparing, the significant differences between the helical IMRT and helical 3D were only found in the heart and contralateral breast. For the dose to the heart, helical IMRT reduced the maximum point dose by 6.98Gy compared to the helical 3D plan (p = 0.01). For contralateral breast, the helical IMRT plans significantly reduced the maximum point dose by 5.6Gy compared to the helical 3D plan. However, compared to the helical 3D plan, the helical IMRT plan increased the volume for lower dose (13.08% increase in V5Gy, p = 0.01). In general, there are no significant differences in dose sparing between helical IMRT and helical 3D plans.
authors.affiliation: Department of Human Oncology, University of Wisconsin-Madison, Madison, WI; Service of Radiation Therapy, University of Wisconsin Aspirus Cancer Center, Wisconsin Rapids, WI.
authors.forename: Poonam
authors.initials: P
authors.lastname: Yadav
authors.affiliation: Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: yyan5@mdanderson.org.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Service of Radiation Therapy, University of Wisconsin Aspirus Cancer Center, Wisconsin Rapids, WI.
authors.forename: Tasha
authors.initials: T
authors.lastname: Ignatowski
authors.affiliation: Department of Human Oncology, University of Wisconsin-Madison, Madison, WI; Service of Radiation Therapy, University of Wisconsin Aspirus Cancer Center, Wisconsin Rapids, WI.
authors.forename: Anna
authors.initials: A
authors.lastname: Olson
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D018270:Carcinoma, Ductal, Breast / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D059351:Organ Sparing Treatments; D058958:Organs at Risk; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies
keywords: Breast cancer; Dose-volume histogram; Intensity-modulated radiotherapy; TomoTherapy