title: Primary cutaneous diffuse large B-cell lymphoma presenting as chronic non-healing ulcer.
abstract: Primary cutaneous diffuse large B-cell lymphoma is an uncommon and aggressive lymphoproliferative disorder with a rapid growth rate and dismal prognosis. We present the case of a 91-year-old female with an unusual manifestation of primary cutaneous diffuse large B-cell lymphoma, mimicking other more prevalent diseases like chronic non-healing venous ulceration. Dermatopathologic evaluation rendered the correct diagnosis. A discussion of this rare presentation is important for clinician consideration to prevent misdiagnosis and prolongation of proper management in patients with chronic non-healing leg ulcers.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Billero
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: LaSenna
authors.affiliation: Department of Dermatology, University of Pisa, Pisa, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Romanelli
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.
authors.forename: Alessio
authors.initials: A
authors.lastname: Giubellino
authors.affiliation: Department of Surgery, Saint Mary's Hospital, Waterbury, CT, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Brenes
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Romanelli
mesh_terms: D000369:Aged, 80 and over; D002908:Chronic Disease / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy*; D011379:Prognosis; D035583:Rare Diseases / Q000175:diagnosis / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D012883:Skin Ulcer / Q000175:diagnosis* / Q000628:therapy*
keywords: Chronic ulcer; Dermatopathology; Leg ulcer; Non-healing ulcer; Primary cutaneous diffuse large B-cell lymphoma leg-type