title: Finding the start site: redefining the human initiator element.
abstract: Transcription by RNA polymerase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the transcription start site (TSS) that help direct the proper initiation of transcription. Taking advantage of recent advances in genome-wide sequencing approaches, Vo ngoc and colleagues (pp. 6-11) identified transcripts with focused sites of initiation and found that many were transcribed from promoters containing a new consensus sequence for the human initiator (Inr) core promoter element.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA.
authors.forename: Jennifer F
authors.initials: JF
authors.lastname: Kugel
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Goodrich
mesh_terms: D001483:Base Sequence; D016384:Consensus Sequence; D006801:Humans; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000235:genetics; D016385:TATA Box; D024363:Transcription Initiation Site; D014158:Transcription, Genetic
chemical_list: D012319:RNA Polymerase II
keywords: RNA polymerase II; core promoter; focused transcription; initiator; transcription start site