title: Anterior segment changes on ultrasound biomicroscopy after intravitreal anti vascular endothelial growth factor injection.
abstract: BACKGROUND
  Intravitreal injections are standard of care today and have the potential to change the anatomy of the anterior segment of the eye. This research was undertaken to evaluate the changes in anterior segment anatomy after intravitreal anti vascular endothelial growth factor (anti VEGF) injections.
  
  
  METHODS
  We conducted a prospective interventional case series at a quaternary care center where patients undergoing intravitreal injection had pre and post injection ultrasound biomicroscopy (UBM) and intraocular pressure (IOP) measurement after intravitreal anti VEGF injection of 0.05 ml volume.
  
  
  RESULTS
  75 eyes of 75 patients as per inclusion criteria were studied. A transient rise in IOP post intravitreal injection was found immediately after the injection. The mean rise from baseline was 17 mmHg immediately after injection and IOP returned to normal within 30 min in all cases. Angle measurement done as per established techniques revealed no significant changes in the angles and anterior chamber.
  
  
  CONCLUSIONS
  Intravitreal anti VEGF injections had no readily apparent short term concerns. IOP rise was transient and no case was found to have IOP high enough to cause concern for interruption of the optic nerve perfusion or statistically significant narrowing of the anterior chamber angle.
authors.affiliation: Senior Advisor (Ophthalmology and Vitreoretinal Surgery), INHS Asvini, Colaba, Mumbai, India.
authors.forename: H S
authors.initials: HS
authors.lastname: Trehan
authors.affiliation: Classified Specialist (Ophthalmology) Command Hospital (Western Command), Chandimandir, India.
authors.forename: Jaya
authors.initials: J
authors.lastname: Kaushik
authors.affiliation: Army Hospital (R&R), New Delhi, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Rangi
authors.affiliation: Classified Specialist (Ophthalmology), INHS Dhanvantari, Port Blair, Andaman and Nicobar Islands, India.
authors.forename: A S
authors.initials: AS
authors.lastname: Parihar
authors.affiliation: Graded Specialist (Ophthalmology), INHS Asvini, Colaba, Mumbai, India.
authors.forename: P
authors.initials: P
authors.lastname: Vashisht
authors.affiliation: Addl DGAFMS (MR, H & Trg), O/o DGAFMS, Ministry of Defence, 'M' Bock, New Delhi 110001, India.
authors.forename: J K S
authors.initials: JK
authors.lastname: Parihar
keywords: Anterior chamber; Anti vascular endothelial growth factor; Intraocular pressure; Intravitreal; Ultrasound biomicroscopy