title: Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China.
abstract: To understand the relationship between the Staphylococcus aureus infection rate and the reasonable usage of antibiotics, which will help in the effective control of MRSA infection.
  
  
  
  All data were obtained by the application of the nosocomial infection surveillance network. Drug resistance, departmental sources, and isolated sites as well as infection rate variations of S. aureus were analyzed in the 7-year period in key departments.
  
  
  
  Between 2008 and 2014, 2525 strains of S. aureus isolates, mainly from sputum, skin/soft tissue, bloodstreams were collected from several hospital departments including respiratory, burn, brain surgery, orthopedics, ICU, and emergency. During these periods, the resistance rate of S. aureus to most drugs, including oxacillin, tetracycline, erythromycin, clindamycin, gentamicin, and ciprofloxacin, showed a tendency to decrease. The resistance to sulphamethoxazole/trimethoprim showed the opposite trend (P = 0.075) and there were no S. aureus strains resistant to linezolid and vancomycin. The MRSA infection rate was different across crucial hospital departments, with the burns department and ICU maintaining a high infection level. Over the 7-year period, both the brain surgery and the emergency departments had an expected upward trend (P < 0.05), while the orthopedic department showed a clear downward trend (P < 0.05) in MRSA infection rate.
  
  
  
  Hospitals should continue to maintain the current pattern of antibiotic administration, while more effective measures should be taken to reduce the high MRSA infection rate in some important hospital departments.
authors.affiliation: Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, 17 Yongwaizhengjie, Nanchang, 330006, China. chenks100@126.com.
authors.forename: Kaisen
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, 17 Yongwaizhengjie, Nanchang, 330006, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: The College of Public Health of Nanchang University, Nanchang, 330006, China.
authors.forename: Qiuyue
authors.initials: Q
authors.lastname: Song
authors.affiliation: The College of Public Health of Nanchang University, Nanchang, 330006, China.
authors.forename: Chenhui
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, 17 Yongwaizhengjie, Nanchang, 330006, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, 17 Yongwaizhengjie, Nanchang, 330006, China.
authors.forename: Lingbing
authors.initials: L
authors.lastname: Zeng
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002681:China / Q000453:epidemiology; D002981:Clindamycin / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology*; D004917:Erythromycin / Q000494:pharmacology; D006784:Hospitals, Teaching; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification* / Q000302:isolation & purification* / Q000502:physiology; D062606:Tertiary Care Centers; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin; D013752:Tetracycline
keywords: China; Drug resistance; S. aureus; Trend