title: Astrovirus Pathogenesis.
abstract: Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the familyAstroviridaehas expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Cydney.Johnson@stjude.org.
authors.forename: Cydney
authors.initials: C
authors.lastname: Johnson
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Virginia.Hargest@stjude.org.|Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Virginia.Hargest@stjude.org.
authors.forename: Virginia
authors.initials: V
authors.lastname: Hargest
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Valerie.Cortez@stjude.org.
authors.forename: Valerie
authors.initials: V
authors.lastname: Cortez
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Victoria.Meliopoulos@stjude.org.
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Meliopoulos
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Stacey.Schultz-Cherry@stjude.org.
authors.forename: Stacey
authors.initials: S
authors.lastname: Schultz-Cherry
mesh_terms: D000818:Animals; D019200:Astroviridae / Q000502:physiology*; D019350:Astroviridae Infections / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans
keywords: animal models; astrovirus; cell culture; pathogenesis