title: Effect of Ioxaglate on the cutaneous microcirculation in patients with coronary artery disease: Randomized, double blind, placebo-controlled study.
abstract: Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography.The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line.VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%.
authors.affiliation: Krankenhaus Dresden-Friedrichstadt, II. Medizinische Klinik, Dresden, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Gerk
authors.affiliation: Institute for Heart and Circulation Research, Eißendorfer Pferdeweg, Hamburg-Harburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Mrowietz
authors.affiliation: Praxisklinik Herz und Gefäße, Dresden, and Brandenburgische Technische Universität (BTU), Cottbus-Senftenberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Sternitzky
authors.affiliation: Department of Biomaterials, Central Institute for Biomedical Engineering, University of Ulm, Ulm, Germany.
authors.forename: R P
authors.initials: RP
authors.lastname: Franke
authors.affiliation: Praxisklinik Herz und Gefäße, Dresden, and Brandenburgische Technische Universität (BTU), Cottbus-Senftenberg, Germany.
authors.forename: S G
authors.initials: SG
authors.lastname: Spitzer
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Jung
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007485:Ioxaglic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D007485:Ioxaglic Acid
keywords: Cutaneous microcirculation; Ioxaglate; coronary artery disease