title: Inflammatory Bowel Disease: A Potential Risk Factor for Coronary Artery Disease.
abstract: Patients with inflammatory bowel disease (IBD) have a higher incidence of coronary artery disease (CAD) compared with the general population. Left main coronary artery (LMCA) thrombosis constitutes a very rare but catastrophic manifestation of acute coronary syndrome. Case reports describing young patients with IBD and LMCA thrombosis are scarce. Most importantly, patients with a positive family history of thrombotic events and those with significant genetic or acquired risk factors such as the antiphospholipid antibody syndrome, advanced age, immobilization, pregnancy, oral contraceptive use, obesity, diabetes, and cigarette smoking may have a higher risk of thrombosis among those with active IBD. We describe a 28-year-old man who was admitted for coronary angiography (CA) due to ST-segment elevation myocardial infarction. He had a recent exacerbation of ulcerative colitis. The patient was a smoker without a family history of CAD. Proximal total occlusion of the left anterior descending (LAD) artery and left circumflex (LCX) artery with massive thrombus was shown on CA, whereas a normal dominant right coronary artery delivered collaterals to the LAD artery.
authors.affiliation: 1 Department of Cardiology, Patras University Hospital, Patras, Greece.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Tsigkas
authors.affiliation: 1 Department of Cardiology, Patras University Hospital, Patras, Greece.
authors.forename: Periklis
authors.initials: P
authors.lastname: Davlouros
authors.affiliation: 1 Department of Cardiology, Patras University Hospital, Patras, Greece.
authors.forename: Stefanos
authors.initials: S
authors.lastname: Despotopoulos
authors.affiliation: 2 Department of Internal Medicine, Patras University Hospital, Patras, Greece.
authors.forename: Stelios F
authors.initials: SF
authors.lastname: Assimakopoulos
authors.affiliation: 3 Department of Gastroenterology, Patras University Hospital, Patras, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Theocharis
authors.affiliation: 1 Department of Cardiology, Patras University Hospital, Patras, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Hahalis
mesh_terms: D000328:Adult; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D004452:Echocardiography; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D012307:Risk Factors
keywords: inflammatory bowel disease; left main thrombosis; myocardial infarction; thromboembolic complications