title: Analysis of the Osteogenic Effects of Biomaterials Using Numerical Simulation.
abstract: We describe the development of an optimization algorithm for determining the effects of different properties of implanted biomaterials on bone growth, based on the finite element method and bone self-optimization theory. The rate of osteogenesis and the bone density distribution of the implanted biomaterials were quantitatively analyzed. Using the proposed algorithm, a femur with implanted biodegradable biomaterials was simulated, and the osteogenic effects of different materials were measured. Simulation experiments mainly considered variations in the elastic modulus (20-3000 MPa) and degradation period (10, 20, and 30 days) for the implanted biodegradable biomaterials. Based on our algorithm, the osteogenic effects of the materials were optimal when the elastic modulus was 1000 MPa and the degradation period was 20 days. The simulation results for the metaphyseal bone of the left femur were compared with micro-CT images from rats with defective femurs, which demonstrated the effectiveness of the algorithm. The proposed method was effective for optimization of the bone structure and is expected to have applications in matching appropriate bones and biomaterials. These results provide important insights into the development of implanted biomaterials for both clinical medicine and materials science.
authors.affiliation: Orthopaedic Institute, Soochow University, Suzhou, China; Department of Fundamental Courses, Wuxi Institute of Technology, Wuxi, China.
authors.forename: Lan
authors.identifier: 0000-0002-4892-4726
authors.initials: L
authors.lastname: Wang
authors.affiliation: Orthopaedic Institute, Soochow University, Suzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Orthopaedic Institute, Soochow University, Suzhou, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, China.
authors.forename: Hui-Lin
authors.initials: HL
authors.lastname: Yang
authors.affiliation: Orthopaedic Institute, Soochow University, Suzhou, China; Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, China.
authors.forename: Zong-Ping
authors.identifier: 0000-0003-4447-805X
authors.initials: ZP
authors.lastname: Luo
mesh_terms: D000465:Algorithms; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001842:Bone and Bones / Q000473:pathology; D003198:Computer Simulation; D005260:Female; D005264:Femoral Fractures / Q000628:therapy; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008422:Materials Testing; D015233:Models, Statistical; D008962:Models, Theoretical; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D016012:Poisson Distribution; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials