title: Impaired Vascular Function in Sarcoidosis Patients.
abstract: A common feature of sarcoidosis and atherosclerosis is a chronic systemic inflammatory reaction. Our hypothesis was that sarcoidosis may negatively influence the vessel status. We addressed the issue by examining preatherosclerotic vascular alternations using an ultrasound-based speckle-tracking method in 72 sarcoidosis patients and 15 matched controls. To find potential factors which may have a deleterious influence on arterial performance, different subgroups of sarcoidosis, such as sarcoidosis with or without cortisone therapy, pulmonary sarcoidosis in early and advanced stages, pulmonary sarcoidosis alone or combined with extrapulmonary sarcoidosis, and sarcoidosis with or without elevated blood levels of angiotensin converting enzyme (ACE)/soluble interleukin 2 receptor (sIL-2R) were investigated. We found in the general collective of sarcoidosis patients that circumferential strain (2.68 ± 0.19%), circumferential strain rate (0.21 ± 0.01 1/s), and radial displacement (0.10 ± 0.01 mm) were significantly decreased compared to controls (3.77 ± 0.35%, 0.28 ± 0.02 1/s, and 0.14 ± 0.02 mm, respectively). Vascular strains were more impaired in patients with cortisone therapy, pulmonary sarcoidosis in stages III-IV, and in pulmonary sarcoidosis accompanied by extrapulmonary involvement. The level of ACE/sIL-2R had no relevant influence on the angiological parameters. In conclusion, sarcoidosis is associated with increased vascular stiffness. Cortisone therapy and advanced stages of pulmonary sarcoidosis with extrapulmonary manifestations may account for the impaired vascular function in this patient collective.
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany. izabela.tuleta@ukb.uni-bonn.de.
authors.forename: I
authors.initials: I
authors.lastname: Tuleta
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Skowasch
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Biener
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pizarro
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schueler
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Nickenig
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Schahab
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schaefer
authors.affiliation: Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Pingel
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D017565:Sarcoidosis, Pulmonary / Q000097:blood* / Q000378:metabolism / Q000473:pathology*
chemical_list: D015375:Receptors, Interleukin-2; D007703:Peptidyl-Dipeptidase A
keywords: Arterial Elastic Properties; Atherosclerosis; Granulomatous Disease; Inflammation; Sarcoidosis Vasculopathy; Vascular Ultrasound