title: [Takotsubo cardiomyopathy recurrence in patient with chronic kidney disease: case report and literature review].
abstract: Takotsubo cardiomyopathy (CT) is a syndrome characterized by an acute and transient left ventricular dysfunction, electrocardiographic abnormalities suggestive of acute coronary syndrome, chest pain and/or dyspnea, left ventricular mid-apical segments akinesia and normal coronary angiography. It is mainly observed in postmenopausal women after an intense physical or mental stress. The course is usually favourable but sometimes severe complications occur. The recurrence rate is 2-10%. We present the case of a recurrence of CT in a female, 79 years old, with hypertension, diabetes, chronic kidney disease (CKD) stage 3 who was admitted to the emergency room for dyspnea and vomiting. The electrocardiogram (ECG) showed a sinusal rhythm and T wave inversion in the pre-cordial leads and the echocardiogram a typical feature of CT with depressed left ventricular systolic function (FE). The ECG ranged quickly with atrial fibrillation rhythm, followed by a major hypokinetic arrhythmia with advanced atrio-ventricular block which indicated the need for a temporary pacemaker placement. The patient was oligouric, with severe renal failure, hyponatremia, hyperkalemia and metabolic acidosis. A continuous renal replacement therapy (CRRT) was started. On the seventh day improvement in urine output, electrolyte and acid base imbalance and FE normalization occurred. The renal function improved gradually, but after 36 months, persisted CKD stage 4. The case report describes the development of a cardiorenal syndrome type 1 induced by CT recurrence and effectiveness of CRRT in the management of acute heart failure. It also suggests a potential role played by CKD as a risk factor in the onset and recurrence of CT.
authors.forename: Francesco
authors.initials: F
authors.lastname: Caccetta
authors.forename: Maurizio
authors.initials: M
authors.lastname: Caroppo
authors.forename: Fernando
authors.initials: F
authors.lastname: Musio
authors.forename: Anna
authors.initials: A
authors.lastname: Mudoni
authors.forename: Antonella
authors.initials: A
authors.lastname: Accogli
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Zacheo
authors.forename: Domenica
authors.initials: D
authors.lastname: Burzo
authors.forename: Rolando
authors.initials: R
authors.lastname: Mangia
authors.forename: Michele
authors.initials: M
authors.lastname: Accogli
authors.forename: Vitale
authors.initials: V
authors.lastname: Nuzzo
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D012008:Recurrence; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D054549:Takotsubo Cardiomyopathy / Q000209:etiology*