title: [Severe infective endocarditis through the history].
abstract: The history of infective endocarditis (IE) is a good example of medical progress. Initially incurable, endocarditis, when diagnosed, was synonym of death. After significant diagnostic progress, thanks to Osler's contribution especially, the first surgeries and antibacterial drugs obtained very few successful cures. We had to wait until Flamming's discovery to observe frequent cures thanks to antibiotics. Surgery manages to push possibilities of cure a bit further. However, paravalvular extensions, described since the first surgical case of IE, was a real technical matter. Thus, the second half of 20th century was devoted to overcoming this surgical challenge. In this historical review, we describe the story of severe IE, especially with paravalvular involvement, by highlighting major progress - clinical and surgical, that allows its current management.
authors.affiliation: Service de chirurgie cardiothoracique et cardiovasculaire, CHU Pontchailloux, 2, rue Henri-le-Guilloux, 35000 Rennes, France. Electronic address: simon.rouze@chu-rennes.fr.
authors.forename: S
authors.initials: S
authors.lastname: Rouzé
authors.affiliation: Service de chirurgie cardiothoracique et cardiovasculaire, CHU Pontchailloux, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors.forename: A
authors.initials: A
authors.lastname: Leguerrier
authors.affiliation: Service de chirurgie cardiothoracique et cardiovasculaire, CHU Pontchailloux, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Verhoye
authors.affiliation: Service de chirurgie cardiothoracique et cardiovasculaire, CHU Pontchailloux, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors.forename: E
authors.initials: E
authors.lastname: Flécher
mesh_terms: D002309:Cardiology / Q000266:history*; D004696:Endocarditis / Q000266:history*; D004739:England; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D013903:Thoracic Surgery / Q000266:history*
keywords: Abcès; Abscess; Chirurgie; Endocardite; Endocarditis; Extension; Fistulae; Fistule; Histoire; History; Paravalvulaire; Paravalvular; Surgery