title: Evaluation of Tc-99m-3PRGD2 Integrin Receptor Imaging in the Differential Diagnosis of Breast Lesions and Comparison With Mammography.
abstract: OBJECTIVE
  The aims of this study were to evaluate and compare efficacies of Tc-99m-3PRGD2 integrin receptor imaging under variety of conditions for the diagnosis of breast lesions, in addition to comparison with mammography.
  
  
  METHODS
  Seventy-two female patients with established breast lesions were recruited. All patients were examined by Tc-99m-3PRGD2 integrin receptor imaging and mammography. Whole-body scan and SPECT/CT were acquired at dual time points of 2 and 4 h after injection using standard protocol. The processed images were evaluated by visual and semi-quantitative analysis. Mammography was performed using up and down and internal and external oblique views. The gold standard of diagnosis was based on histopathological findings.
  
  
  RESULTS
  Sensitivity greater than 85.0% and accuracy greater than 80.0% were observed under any technical method. For dense mammary gland, the sensitivity, specificity, and accuracy of Tc-99m-3PRGD2 SPECT/CT 4-h imaging and mammography were 95.2, 75.0, and 90.7%, and 71.4, 58.3, and 68.5% respectively. Combined two methods' sensitivity, specificity, and accuracy for detection of breast cancer can reach 98.3, 86.7, and 96.0%.
  
  
  CONCLUSIONS
  Tc-99m-3PRGD2-based molecular imaging is a sensitive method for the differential diagnosis of breast lesions. Particularly, Tc-99m-3PRGD2-SPECT/CT has better diagnostic value in dense mammary gland as compared with mammography. Combining two methods can significantly improve the diagnostic efficiency.
authors.affiliation: a Department of Nuclear Medicine , The First Affiliated Hospital of Xiamen University , Xiamen , China.
authors.forename: Guibing
authors.initials: G
authors.lastname: Chen
authors.affiliation: b Department of Breast Surgery , The First Affiliated Hospital of Xiamen University , Xiamen , China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Ouyang
authors.affiliation: c Medical Isotopes Research Center, Peking University , Beijing , China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: d Department of Nuclear Medicine & Minnan PET Center , The First Affiliated Hospital of Xiamen University , Xiamen , China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.affiliation: c Medical Isotopes Research Center, Peking University , Beijing , China.
authors.forename: Bing
authors.initials: B
authors.lastname: Jia
authors.affiliation: e Department of Radiology , University of Virginia , Charlottesville , Virginia , USA.
authors.forename: Mahendra D
authors.initials: MD
authors.lastname: Chordia
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000032:analysis*; D010456:Peptides, Cyclic / Q000032:analysis*; D019275:Radiopharmaceuticals / Q000032:analysis*; D000072098:Single Photon Emission Computed Tomography Computed Tomography / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; D010456:Peptides, Cyclic; D019275:Radiopharmaceuticals; C561921:technetium 99m (HYNIC-3PRGD(2))(tricine)(TPPTS)
keywords: SPECT; Tc-99m-3PRGD2; breast neoplasms; diagnosis; differential; mammography