title: A Receptor on Acid.
abstract: Wacker et al. report the crystal structure of LSD in complex with one of its major targets in the brain, the 5-HT2Breceptor, the first such structure for any psychedelic drug. The results shed light on the molecular mechanisms underlying its ability to induce hallucinations with greater duration and potency than closely related compounds.
authors.affiliation: The Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Chen
authors.affiliation: The Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: tesmerjj@umich.edu.
authors.forename: John J G
authors.initials: JJG
authors.lastname: Tesmer
mesh_terms: D001921:Brain / Q000187:drug effects; D006213:Hallucinogens / Q000494:pharmacology*; D008238:Lysergic Acid Diethylamide / Q000031:analogs & derivatives*
chemical_list: D006213:Hallucinogens; D008238:Lysergic Acid Diethylamide