title: Effects of acute buspirone administration on inhibitory control and sexual discounting in cocaine users.
abstract: Cocaine users display deficits in inhibitory control and make impulsive choices that may increase risky behavior. Buspirone is an anxiolytic that activates dopaminergic and serotonergic systems and improves impulsive choice (i.e., reduces sexual risk-taking intent) in cocaine users when administered chronically. We evaluated the effects of acutely administered buspirone on inhibitory control and impulsive choice.
  
  
  
  Eleven subjects with a recent history of cocaine use completed this within-subject, placebo-controlled study. Subjects performed two cued go/no-go and a sexual risk delay-discounting task following oral administration of buspirone (10 and 30 mg), triazolam (0.375 mg; positive control), and placebo (negative control). Physiological and psychomotor performance and subject-rated data were also collected.
  
  
  
  Buspirone failed to change inhibitory control or impulsive choice; however, slower reaction times were observed at the highest dose tested. Buspirone did not produce subject-rated drug effects but dose-dependently decreased diastolic blood pressure. Triazolam impaired psychomotor performance and increased ratings of positive subject-rated effects (e.g., Like Drug).
  
  
  
  These findings indicate that acutely administered buspirone has little impact on behavioral measures of inhibitory control and impulsive sexual decision-making. Considering previous findings with chronic dosing, these findings highlight that the behavioral effects of buspirone differ as a function of dosing conditions.
authors.affiliation: Department of Psychology, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Strickland
authors.affiliation: Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: B Levi
authors.initials: BL
authors.lastname: Bolin
authors.affiliation: College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Romanelli
authors.affiliation: Department of Psychology, University of Kentucky, Lexington, Kentucky, USA.|Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.|Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Craig R
authors.initials: CR
authors.lastname: Rush
authors.affiliation: Department of Psychology, University of Kentucky, Lexington, Kentucky, USA.|Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.|Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Stoops
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D002065:Buspirone / Q000008:administration & dosage*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D065786:Delay Discounting / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012725:Sexual Behavior / Q000187:drug effects* / Q000502:physiology / Q000523:psychology*
chemical_list: D014151:Anti-Anxiety Agents; D002065:Buspirone
keywords: impulsivity; pharmacotherapy; response inhibition; substance use; triazolam