title: Relationship between Serum Levels of Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinases-1 and Exercise Test Results in Postmenopausal Women.
abstract: Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well as all the processes taking part in maintenance of efficient homeostasis. Presentation of the correlation between exercise test results and MMP-8 (metalloproteinase-8) and TIMP-1 (tissue inhibitor of metalloproteinases-1) levels was attempted in this work. MMP-8 is a proteolytic enzyme taking part in progression of diseases related to process of ageing. 62 healthy women in postmenopausal period were qualified for the study (mean age: 54 ± 3.6). There was exercise test on the treadmill according to Bruce's protocol performed. MMP-8 and TIMP-1 serum levels were measured. There was statistically important correlation between increased level of MMP-8 and increased level of TIMP-1 with lower results of exercise test observed. The conducted study provides further biochemical arguments for prophylactic role of physical activity, which lowers the risk of noninfectious diseases, typical for middle adulthood, by influencing physical capacity.
authors.affiliation: Department of Internal Diseases, Medical University of Lublin, Lublin, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Mieczkowska
authors.affiliation: Department of Tourism and Recreation, University of Life Sciences in Lublin, Lublin, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Rutkowska
authors.affiliation: Department of Internal Diseases, Medical University of Lublin, Lublin, Poland.
authors.forename: J
authors.identifier: 0000-0003-0320-1863
authors.initials: J
authors.lastname: Mosiewicz
authors.affiliation: Department of Internal Diseases, Students Medical Associations, Medical University of Lublin, Lublin, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Mosiewicz
mesh_terms: D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006339:Heart Rate; D006801:Humans; D020784:Matrix Metalloproteinase 8 / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C488762:MMP8 protein, human; D020784:Matrix Metalloproteinase 8