title: Directing traffic on DNA-How transcription factors relieve or induce transcriptional interference.
abstract: Transcriptional interference (TI) is increasingly recognized as a widespread mechanism of gene control, particularly given the pervasive nature of transcription, both sense and antisense, across all kingdoms of life. Here, we discuss how transcription factor binding kinetics strongly influence the ability of a transcription factor to relieve or induce TI.
authors.affiliation: a Department of Molecular and Cellular Biology , School of Biological Sciences, University of Adelaide , Adelaide , SA , Australia.
authors.forename: Nan
authors.initials: N
authors.lastname: Hao
authors.affiliation: b Department of Systems Biology , Harvard Medical School , Boston , MA , USA.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Palmer
authors.affiliation: a Department of Molecular and Cellular Biology , School of Biological Sciences, University of Adelaide , Adelaide , SA , Australia.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Dodd
authors.affiliation: a Department of Molecular and Cellular Biology , School of Biological Sciences, University of Adelaide , Adelaide , SA , Australia.
authors.forename: Keith E
authors.initials: KE
authors.lastname: Shearwin
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004330:Drosophila; D008089:Listeria monocytogenes / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D050543:Phosphoglycerate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D004718:Saccharomycetales / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D004247:DNA; D050543:Phosphoglycerate Dehydrogenase; C493278:SER3 protein, S cerevisiae; D012321:DNA-Directed RNA Polymerases
keywords: DNA-binding kinetics; convergent promoters; dislodgement; roadblock; transcriptional interference