title: Size-Dependent Ag2S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy.
abstract: Ag2S nanoparticles are increasingly important in biomedicine, such as in cancer imaging. However, there has been only limited success in the exploration of theranostic Ag2S nanoparticles for photoinduced cancer imaging and simultaneous therapy. Here we report size-dependent Ag2S nanodots (NDs) with well-defined nanostructure as a theranostic agent for multimodal imaging and simultaneous photothermal therapy. The NDs are precisely synthesized through carefully controlled growth of Ag2S in hollow human serum albumin nanocages. These NDs produce effective fluorescence in second near-infrared (NIR-II) region, distinct photoacoustic intensity, and good photothermal conversion in a size-dependent manner under light irradiation, thereby generating sufficient in vivo fluorescence and photoacoustic signals as well as potent hyperthermia at tumors. Moreover, Ag2S NDs possess ideal resistance to photobleaching, effective cellular uptake, preferable tumor accumulation, and in vivo elimination, thus facilitating NIR-II fluorescence/photoacoustics imaging with both ultrasensitivity and microscopic spatial resolution and simultaneous photothermal tumor ablation. These findings provide insight into the clinical potential of Ag2S nanodots for cancer theranostics.
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: National Engineering Research Center for Nanomedicine and College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Yong'an
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lv
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Hengte
authors.initials: H
authors.lastname: Ke
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: National Engineering Research Center for Nanomedicine and College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen 361102, China.
authors.forename: Gang
authors.identifier: 0000-0003-2613-7286
authors.initials: G
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Center of Excellence for Nanosciences, National Center for Nanoscience and Technology of China , Beijing 100190, China.
authors.forename: Yuliang
authors.identifier: 0000-0002-9586-9360
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University , Suzhou 215123, China.|School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University , Suzhou 215123, China.
authors.forename: Huabing
authors.identifier: 0000-0003-1637-2872
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007259:Infrared Rays; D051379:Mice; D064847:Multimodal Imaging; D049329:Nanostructures / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging; D061848:Optical Imaging; D010316:Particle Size; D055668:Photochemical Processes; D010789:Phototherapy; D016062:Porosity; D045663:Quantum Dots / Q000737:chemistry*; D000075462:Serum Albumin, Human / Q000737:chemistry; D018030:Silver Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D018030:Silver Compounds; C013251:silver sulfide; D000075462:Serum Albumin, Human
keywords: Ag2S nanodot; albumin nanocage; photothermal therapy; second near-infrared fluorescence; tumor ablation