title: The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project.
abstract: Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for demographics, cardiovascular risk factor, severe edentulism, symptoms of depression, the MoCA score, and neuroimaging signatures of cerebrovascular damage), poor sleep quality was associated with GCA (p=0.004). A multivariate probability model showed that the probability of moderate-to-severe GCA significantly increased in individuals with poor sleep quality aged ≥67 years. This study provides evidence for an association between poor sleep quality and GCA in older adults and the important interaction of age in this association.
authors.affiliation: School of Medicine, Universidad Espíritu Santo - Ecuador, Guayaquil, Ecuador.
authors.forename: Oscar H
authors.initials: OH
authors.lastname: Del Brutto
authors.affiliation: Vanderbilt University Medical Center, Nashville, TN, United States.
authors.forename: Robertino M
authors.initials: RM
authors.lastname: Mera
authors.affiliation: Community Center, The Atahualpa Project, Atahualpa, Ecuador.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Zambrano
authors.affiliation: Sleep Disorders Center, Mayo Clinic College of Medicine, Jacksonville, FL, United States.
authors.forename: Pablo R
authors.initials: PR
authors.lastname: Castillo
keywords: Global cortical atrophy; Older adults; Pittsburgh Sleep Quality Index; Population-based study; Sleep quality