title: Cytokine networks and their association with Helicobacter pylori infection in gastric carcinoma.
abstract: Cytokine networks as dynamic networks are pivotal aspects of tumor immunology, especially in gastric cancer (GC), in which infection, inflammation, and antitumor immunity are key elements of disease progression. In this review, we describe functional roles of well-known GC-modulatory cytokines, highlight the functions of cytokines with more recently described roles in GC, and emphasize the therapeutic potential of targeting the complex cytokine milieu. We also focus on the role of Helicobacter pylori (HP)-induced inflammation in GC and discuss how HP-induced chronic inflammation can lead to the induction of stem cell hyperplasia, morphological changes in gastric mucosa and GC development.
authors.affiliation: Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Human Genetic Division, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.|Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Bagheri
authors.affiliation: Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Pathology, Faculty of Medicine, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Bahram
authors.initials: B
authors.lastname: Memar
authors.affiliation: Department of Medical Biotechnology, Student Research Committee, Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amir Abbas
authors.initials: AA
authors.lastname: Momtazi
authors.affiliation: Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.affiliation: Human Genetic Division, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Gholamin
authors.affiliation: Human Genetic Division, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.|Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Abbaszadegan
mesh_terms: D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000382:microbiology* / Q000473:pathology
chemical_list: D016207:Cytokines
keywords: Helicobacter pylori; cytokines; gastric cancer