title: The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin.
abstract: This study was designed to investigate the effects of 2450 MHz EMR on the heart and blood in rat and possible ameliorating effects of melatonin.
  
  
  
  Thirty-two female Wistar Albino rats were randomly grouped (by eight in each group) as follows:  Group I: cage-control group (dimethysulfoxide (DMSO), 10mg/kg/day i.p. without stress and EMR. Group II: sham-control rats stayed in restrainer without EMR and DMSO (10mg/kg/day i.p.). Group III: rats exposed to 2450 MHz EMR. Group IV: treated group rats exposed to 2450 MHz EMR+melatonin (MLT) (10mg/kg/day i.p.).
  
  
  
  In the blood tissue, there was no significant difference between the groups in respect of erythrocytes GSH, GSH-Px activity, plasma LP level and vitamin A concentration (p > 0.05). However, in the Group IV, erythrocytes' LP levels (p < 0.05) were observed to be significantly decreased while plasma vitamin C, and vitamin E concentrations (p < 0.05) were found to be increased when compared to Group III. In the heart tissues, MDA and NO levels significantly increased in group III compared with groups I and II (p < 0.05). Contrary to these oxidant levels, CAT and SOD enzyme activities decreased significantly in group III compared with groups I and II (p 0.05). Besides, MLT treatment lowered the MDA and NO levels compared with group III.
  
  
  
  In conclusion, these results demonstrated that contrary to its effect on the heart, the wireless (2450 MHz) devices cause slight oxidative-antioxidative changes in the blood of rats, and a moderate melatonin supplementation may play an important role in the antioxidant system (plasma vitamin C and vitamin E). However, further investigations are required to clarify the mechanism of action of the applied 2450 MHz EMR exposure (Tab. 3, Fig. 1, Ref. 49).
authors.forename: N
authors.initials: N
authors.lastname: Gumral
authors.forename: M
authors.initials: M
authors.lastname: Saygin
authors.forename: H
authors.initials: H
authors.lastname: Asci
authors.forename: A C
authors.initials: AC
authors.lastname: Uguz
authors.forename: O
authors.initials: O
authors.lastname: Celik
authors.forename: D K
authors.initials: DK
authors.lastname: Doguc
authors.forename: H B
authors.initials: HB
authors.lastname: Savas
authors.forename: S
authors.initials: S
authors.lastname: Comlekci
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D060733:Electromagnetic Radiation; D004912:Erythrocytes; D005260:Female; D006321:Heart / Q000528:radiation effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D008550:Melatonin; D001205:Ascorbic Acid
keywords: 2450 MHz electromagnetic radiation; heart and blood of rat; oxidant-antioxidant system melatonin.