title: Shutting down the power supply for DNA repair in cancer cells.
abstract: Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.
authors.affiliation: Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9723GZ Groningen, Netherlands m.vugt@umcg.nl.
authors.forename: Marcel A T M
authors.identifier: 0000-0002-3202-4678
authors.initials: MA
authors.lastname: van Vugt
mesh_terms: D004260:DNA Repair; D006019:Glycolysis; D006801:Humans; D009369:Neoplasms; D010736:Phosphoglycerate Mutase / Q000235:genetics*; D059767:Recombinational DNA Repair
chemical_list: D010736:Phosphoglycerate Mutase