title: [Biodegradable synthetic polymers for the design of implantable medical devices: the ligamentoplasty case].
abstract: The sector of implantable medical devices is a growing sector of health products especially dynamic in the field of research. To improve the management of patients and to meet clinical requirements, researchers are developing new types of medical devices. They use different families of biomaterials presenting various chemical and physical characteristics in order for providing clinicians with health products optimized for biomedical applications. In this article, we aim to show how, starting from a family of biomaterials (degradable polymers), it is possible to design an implantable medical device for the therapeutic management of the failure of anterior cruciate ligament. The main steps leading to the design of a total ligament reinforcement are detailed. They range from the synthesis and characterization of degradable polymer to the shaping of the knitted implant, through the assessment of the study of the impact of sterilization on mechanical properties and checking cytocompatibility.
authors.affiliation: Département Biopolymères Artificiels : Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, Faculté de Pharmacie, Bâtiment I, 15, avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Garric
authors.affiliation: Département Biopolymères Artificiels : Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, Faculté de Pharmacie, Bâtiment I, 15, avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Nottelet
authors.affiliation: Département Biopolymères Artificiels : Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, Faculté de Pharmacie, Bâtiment I, 15, avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France.
authors.forename: Coline
authors.initials: C
authors.lastname: Pinese
authors.affiliation: Département Biopolymères Artificiels : Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, Faculté de Pharmacie, Bâtiment I, 15, avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Leroy
authors.affiliation: Département Biopolymères Artificiels : Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, Faculté de Pharmacie, Bâtiment I, 15, avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Coudane
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D063566:Biodegradable Plastics / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D004867:Equipment Design / Q000379:methods*; D006801:Humans; D008022:Ligaments / Q000601:surgery*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D019651:Plastic Surgery Procedures / Q000379:methods / Q000639:trends; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends
chemical_list: D001672:Biocompatible Materials; D063566:Biodegradable Plastics; D011108:Polymers