title: Roseburia spp.: a marker of health?
abstract: The genus Roseburia consists of obligate Gram-positive anaerobic bacteria that are slightly curved, rod-shaped and motile by means of multiple subterminal flagella. It includes five species: Roseburia intestinalis, R. hominis, R. inulinivorans, R. faecis and R. cecicola. Gut Roseburia spp. metabolize dietary components that stimulate their proliferation and metabolic activities. They are part of commensal bacteria producing short-chain fatty acids, especially butyrate, affecting colonic motility, immunity maintenance and anti-inflammatory properties. Modification in Roseburia spp. representation may affect various metabolic pathways and is associated with several diseases (including irritable bowel syndrome, obesity, Type 2 diabetes, nervous system conditions and allergies). Roseburia spp. could also serve as biomarkers for symptomatic pathologies (e.g., gallstone formation) or as probiotics for restoration of beneficial flora.
authors.affiliation: INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Tamanai-Shacoori
authors.affiliation: INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.
authors.forename: Imen
authors.initials: I
authors.lastname: Smida
authors.affiliation: INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.
authors.forename: Latifa
authors.initials: L
authors.lastname: Bousarghin
authors.affiliation: INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Loreal
authors.affiliation: INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.|CHU Rennes, 2 rue Henri Le Guilloux, 35000 Rennes, France.|Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Meuric
authors.affiliation: Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France.
authors.forename: Shao Bing
authors.initials: SB
authors.lastname: Fong
authors.affiliation: INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.|CHU Rennes, 2 rue Henri Le Guilloux, 35000 Rennes, France.|Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Bonnaure-Mallet
authors.affiliation: INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.|CHU Rennes, 2 rue Henri Le Guilloux, 35000 Rennes, France.|Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Jolivet-Gougeon
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000382:microbiology / Q000628:therapy; D004032:Diet; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000382:microbiology / Q000628:therapy; D009765:Obesity / Q000382:microbiology / Q000628:therapy; D056692:Prebiotics; D019936:Probiotics
chemical_list: D000890:Anti-Infective Agents; D056692:Prebiotics
keywords: Roseburia spp.; butyrate; diet; irritable bowel syndrome; microbiota; nervous system