title: Piceatannol extends the lifespan of Caenorhabditis elegans via DAF-16.
abstract: Piceatannol is a natural stilbene with many beneficial effects, such as antioxidative, anti-inflammatory, antiatherogenic activities; however, its role on aging is not known. In this study, we used Caenorhabditis elegans as an animal model to study the effect of piceatannol on its lifespan and investigated the underlying mechanisms. The results showed that 50 and 100 µM piceatannol significantly extended the lifespan of C. elegans without altering the growth rate, worm size and progeny production. Piceatannol delayed the age-related decline of pumping rate and locomotive activity, and protected the worms from heat and oxidative stress. This study further indicated that lifespan extension and enhanced stress resistance induced by piceatannol requires DAF-16. Since DAF-16 is conserved from nematodes to mammals, our study may have important implications in utilizing piceatannol to promote healthy aging and combat age-related disease in humans. © 2016 BioFactors, 43(3):379-387, 2017.
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Peiyi
authors.initials: P
authors.lastname: Shen
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Yiren
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Quancai
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Bow High School, Bow, NH, USA.
authors.forename: Nandita
authors.initials: N
authors.lastname: Kasireddy
authors.affiliation: Department of Food Science, Purdue University, West Lafayette, IN, USA.|Center for Cancer Research Purdue University, West Lafayette, IN, USA.
authors.forename: Kee-Hong
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Yeonhwa
authors.initials: Y
authors.lastname: Park
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006358:Hot Temperature; D006801:Humans; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008136:Longevity / Q000187:drug effects* / Q000235:genetics; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction; D013267:Stilbenes / Q000494:pharmacology*; D013312:Stress, Physiological / Q000235:genetics
chemical_list: D000975:Antioxidants; D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D017382:Reactive Oxygen Species; D013267:Stilbenes; C108831:daf-16 protein, C elegans; C041525:3,3',4,5'-tetrahydroxystilbene
keywords: C. elegans; daf-16; lifespan; piceatannol