title: Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay.
abstract: Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses. As for every other antiviral immune system, there is also evidence of viruses interfering with and modulating NMD to their own advantage. This review will discuss our current understanding of why and how NMD targets viral RNAs, and elaborate counter-defense strategies viruses utilize to escape NMD.
authors.affiliation: Department of Biosciences, University of Helsinki, Helsinki FIN-00014, Finland. giuseppe.balistreri@helsinki.fi.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Balistreri
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern CH-3012, Switzerland. claudia.bognanni@dcb.unibe.ch.|Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern CH-3012, Switzerland. claudia.bognanni@dcb.unibe.ch.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bognanni
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern CH-3012, Switzerland. oliver.muehlemann@dcb.unibe.ch.
authors.forename: Oliver
authors.initials: O
authors.lastname: Mühlemann
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D059365:Nonsense Mediated mRNA Decay; D012328:RNA Viruses / Q000276:immunology* / Q000502:physiology*; D014779:Virus Replication
keywords: RNA quality control; RNA-protein interactions; gene expression; translation