title: Management of peripheral neuropathy induced by chemotherapy in adults with cancer: a review.
abstract: OBJECTIVE
  To identify which of the examined agents or modalities were effective in the management of chemotherapy-induced peripheral neuropathy (CIPN).
  
  
  METHODS
  PubMed, CINAHL, Medline, Science Direct and Ovid databases were used to search keywords. The literature search identified 59 potentially relevant studies; after removing duplicates and reviewing titles a total of 26 articles were examined. In the end, a total of 18 studies met the inclusion criteria.
  
  
  RESULTS
  The preliminary data for using lafutidine, acupuncture and sweet bee venom pharmacopuncture indicate that they may be useful in CIPN management. The use of duloxetine was effective and supported as a management of CIPN; likewise the use of scrambler therapy significantly decreased CIPN pain. However, the use of electroacupuncture and topical amitriptyline and ketamine was not supported.
  
  
  CONCLUSIONS
  The use of duloxetine was effective in CIPN management. Further studies with larger sample size are needed.
authors.affiliation: Hashemite University, Faculty of Nursing.
authors.forename: Nijmeh
authors.initials: N
authors.lastname: Al-Atiyyat
authors.affiliation: Pain Management Nurse, King Hussein Cancer Center, Hashemite University.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Obaid
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: Antineoplastic drugs; Chemotherapy-induced peripheral neuropathy; Management; Sensory neurotoxicity