title: Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment.
abstract: Objective. The study goals were to evaluate performance of SLE classification criteria, to define patients with incomplete lupus erythematosus (ILE), and to probe for features in these patients that might be useful as indicators of disease status and hydroxychloroquine response.Methods. Patients with ILE (N= 70) and SLE (N= 32) defined by the 1997 American College of Rheumatology criteria were reclassified using the 2012 Systemic Lupus International Collaborating Clinics criteria. Disease activity, patient reported outcomes, and levels of Type I interferon- (IFN-) inducible genes, autoantibodies, and cytokines were measured. Subgroups treated with hydroxychloroquine (HCQ) were compared to patients not on this drug.Results. The classification sets were correlated (R2= 0.87). ILE patients were older (P= 0.0043) with lower disease activity scores (P< 0.001) and greater dissatisfaction with health status (P= 0.034) than SLE patients. ILE was associated with lower levels of macrophage-derived cytokines and levels of expressed Type I IFN-inducible genes. Treatment of ILE with HCQ was associated with better self-reported health status scores and lower expression levels of Type I IFN-inducible genes than ILE patients not on HCQ.Conclusion. The 2012 SLICC SLE classification criteria will be useful to define ILE in trials. Patients with ILE have better health status and immune profiles when treated with HCQ.
authors.affiliation: Division of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA, USA.
authors.forename: Nancy J
authors.identifier: 0000-0002-6588-3364
authors.initials: NJ
authors.lastname: Olsen
authors.affiliation: Division of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA, USA.
authors.forename: Carl
authors.initials: C
authors.lastname: McAloose
authors.affiliation: Division of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA, USA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Carter
authors.affiliation: Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Bobby Kwanghoon
authors.initials: BK
authors.lastname: Han
authors.affiliation: Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Indu
authors.initials: I
authors.lastname: Raman
authors.affiliation: Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Quan-Zhen
authors.identifier: 0000-0002-7257-0489
authors.initials: QZ
authors.lastname: Li
authors.affiliation: Department of Public Health Sciences, Penn State University, College of Medicine, Hershey, PA, USA.
authors.forename: Duanping
authors.initials: D
authors.lastname: Liao