title: Hormone receptor status and survival of medullary breast cancer patients. A Turkish cohort.
abstract: OBJECTIVE
  To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis.
  
  
  RESULTS
  Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p less than 0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p less than 0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p greater than 0.05).  Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.
authors.affiliation: Department of Medical Oncology, Medical Faculty, Firat University Elazig, Turkey. E-mail. asudeaksoy@hotmail.com.
authors.forename: Asude
authors.initials: A
authors.lastname: Aksoy
authors.forename: Hatice
authors.initials: H
authors.lastname: Odabas
authors.forename: Serap
authors.initials: S
authors.lastname: Kaya
authors.forename: Oktay
authors.initials: O
authors.lastname: Bozkurt
authors.forename: Mustafa
authors.initials: M
authors.lastname: Degirmenci
authors.forename: Turkan O
authors.initials: TO
authors.lastname: Topcu
authors.forename: Aydin
authors.initials: A
authors.lastname: Aytekin
authors.forename: Erkan
authors.initials: E
authors.lastname: Arpaci
authors.forename: Nilufer
authors.initials: N
authors.lastname: Avci
authors.forename: Kezban N
authors.initials: KN
authors.lastname: Pilanci
authors.forename: Havva Y
authors.initials: HY
authors.lastname: Cinkir
authors.forename: Yakup
authors.initials: Y
authors.lastname: Bozkaya
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Cirak
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gumus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D018276:Carcinoma, Medullary / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis*; D012189:Retrospective Studies; D016019:Survival Analysis; D014421:Turkey / Q000453:epidemiology
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone