title: Parathyroid Hormone Levels in the Prediction of Ischemic Stroke Risk.
abstract: Objective. It was examined whether PTH and 25-dihydroxyvitamin D (25(OH)D) levels, together or separately, are indicators of the risk of stroke.Materials and Methods. This prospective study was performed at two centers. In the study, 100 patients diagnosed with acute ischemic stroke and 100 control individuals in the same age range were examined. In addition to neurological examination, cranial imaging, extensive routine blood chemistry, PTH, and 25(OH)D levels were evaluated in all cases. Stroke risk factors were determined. Logistic regression was used for statistical analysis.Results. A total of 60 patients and 79 control individuals were included in the study. Different estimation models were designed in order to examine the relationship between PTH and 25(OH)D levels with stroke. According to modeling results, it was determined that the most effective predictor for risk of stroke was 25(OH)D levels, followed by hypertension and PTH levels, respectively.Conclusion. PTH and 25(OH)D levels together can make important contributions to determination of stroke risk, and further investigations are needed to understand this relationship more fully.
authors.affiliation: Beyhekim State Hospital, Department of Neurology, Konya, Turkey.
authors.forename: Güner
authors.identifier: 0000-0002-2477-3660
authors.initials: G
authors.lastname: Çelik
authors.affiliation: Bandırma State Hospital, Department of Neurology, Balıkesir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Doğan
authors.affiliation: Department of Neurology, Başkent University, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Şefik
authors.initials: Ş
authors.lastname: Dener
authors.affiliation: Department of Neurology, Selçuk Medical Faculty, Selçuk University, Konya, Turkey.
authors.forename: Şerefnur
authors.initials: Ş
authors.lastname: Öztürk
authors.affiliation: Department of Biochemistry, Başkent University, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Sevsen
authors.initials: S
authors.lastname: Kulaksızoğlu
authors.affiliation: Department of Neurology, Selçuk Medical Faculty, Selçuk University, Konya, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ekmekçi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002545:Brain Ischemia / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D016022:Case-Control Studies; D004100:Dihydroxycholecalciferols / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D020521:Stroke / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D015415:Biomarkers; D004100:Dihydroxycholecalciferols; D010281:Parathyroid Hormone