title: [Blast-like tumor tissue in cervical lymph node with expression of placental alkaline phosphatase].
abstract: We report a case of ALK1-positive anaplastic large cell lymphoma with expression of placental alkaline phosphatase (PLAP) in many tumor cells. Initially, due to the positivity of tumor cells for CD30 and PLAP, lymph node metastasis of a germ cell neoplasm was discussed. Anaplastic large cell lymphomas of T‑cell lineage form a group of rare non-Hodgkin lymphomas with heterogeneous morphological and immunohistochemical appearance. They may imitate other neoplasms, such as large cell B‑cell lymphomas, metastasis of a carcinoma, melanoma, embryonal carcinoma or seminoma, rhabdomyosarcoma and inflammatory myofibroblastic tumor. Only an extended immunohistochemistry panel leads to an accurate diagnosis.
authors.affiliation: Institut für Pathologie, Hegau-Bodensee-Kliniken des Gesundheitsverbundes Landkreis Konstanz, Akademisches Lehrkrankenhaus der Universität Freiburg, Virchowstr. 10c, 78224, Singen, Deutschland. Christian.Fellbaum@glkn.de.
authors.forename: C
authors.initials: C
authors.lastname: Fellbaum
authors.affiliation: Institut für Pathologie und Comprehensive Cancer Center Mainfranken, Universität Würzburg, Würzburg, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Kircher
authors.affiliation: Institut für Pathologie, Hegau-Bodensee-Kliniken des Gesundheitsverbundes Landkreis Konstanz, Akademisches Lehrkrankenhaus der Universität Freiburg, Virchowstr. 10c, 78224, Singen, Deutschland.
authors.forename: U
authors.initials: U
authors.lastname: Oehler
authors.affiliation: Praxisklinik für Hals-Nasen-Ohren-Heilkunde, Singen, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Blessing
authors.affiliation: Institut für Pathologie und Comprehensive Cancer Center Mainfranken, Universität Würzburg, Würzburg, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Rosenwald
mesh_terms: D030301:Activin Receptors, Type II / Q000235:genetics; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism*; D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D009333:Neck; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental
keywords: ALK‑1; Cytokeratin; Immunophenotyping; Non-Hodgkin lymphoma; Placental alkaline phosphatase (PLAP); T-cell type