title: Helical tomotherapy of spinal chordomas: French Multicentric, retrospective study of a cohort of 30 cases.
abstract: OBJECTIVE
  To evaluate the efficacy and toxicity of helical tomotherapy (HT) in the management of spine chordomas when proton therapy is unavailable or non-feasible.
  
  
  METHODS
  Between 2007 and 2013, 30 patients with biopsy-proven chordomas were treated by HT in five French institutions. Information regarding local control (LC), overall survival (OS), progression-free survival (PFS) and metastasis-free survival (MFS) was collected. Clinical efficacy, toxicity and treatment quality were evaluated.
  
  
  RESULTS
  Two-year actuarial LC, OS, PFS and MFS were 69.9%, 96.7%, 61.2% and 76.4%, respectively. HT treatments were well tolerated and no Grade 4-5 toxicities were observed. HT permitted the delivery of a mean dose of 68 Gy while respecting organ at risk (OAR) dose constraints, in particular in the spinal cord and cauda equina.
  
  
  CONCLUSIONS
  This multicentric, retrospective study demonstrated the feasibility of HT in the treatment of spine chordomas, in the absence of hadron therapy.
authors.affiliation: Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076, Bordeaux, France. m.bobin@bordeaux.unicancer.fr.|University of Bordeaux, Bordeaux Cedex, France. m.bobin@bordeaux.unicancer.fr.
authors.forename: Maxime
authors.initials: M
authors.lastname: Bobin
authors.affiliation: Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076, Bordeaux, France.
authors.forename: Christina
authors.initials: C
authors.lastname: Zacharatou
authors.affiliation: Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076, Bordeaux, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Sargos
authors.affiliation: Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076, Bordeaux, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Brouste
authors.affiliation: Department of Radiation Oncology, Institut de Cancérologie de l'Ouest René Gauducheau, Comprehensive Cancer Center, Saint-Herblain Cedex, France.
authors.forename: Albert
authors.initials: A
authors.lastname: Lisbona
authors.affiliation: Department of Radiation Oncology, Institut de Cancérologie de l'Ouest René Gauducheau, Comprehensive Cancer Center, Saint-Herblain Cedex, France.
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Mahé
authors.affiliation: Department of Radiotherapy, Centre Paul Strauss, Comprehensive Cancer Center, 3 rue de la Porte-de-l'Hôpital, BP 42, 67065, Strasbourg, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Noël
authors.affiliation: Department of Radiotherapy, Hôpital de la Pitié-Salpêtrière-Charles-Foix, Assistance Publique Hôpitaux de Paris, 47-83, boulevard de l'Hôpital, 75013, Paris, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Halley
authors.affiliation: Department of Radiotherapy, Hôpital de la Pitié-Salpêtrière-Charles-Foix, Assistance Publique Hôpitaux de Paris, 47-83, boulevard de l'Hôpital, 75013, Paris, France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Feuvret
authors.affiliation: Academic Radiation Oncology Department, Centre Oscar Lambret, Comprehensive Cancer Center, 3 rue Frédéric Combemale, Lille, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Gras
authors.affiliation: Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076, Bordeaux, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Hoppe
authors.affiliation: Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076, Bordeaux, France.
authors.forename: Bénédicte Henriques
authors.initials: BH
authors.lastname: de Figueiredo
authors.affiliation: Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076, Bordeaux, France.|University of Bordeaux, Bordeaux Cedex, France.
authors.forename: Guy
authors.initials: G
authors.lastname: Kantor
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002817:Chordoma / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D015996:Survival Rate
keywords: Helical tomotherapy; Local control; Spinal chordomas; Survival rates