title: Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.
abstract: Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.|Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhuo
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Kang