title: Peptide hormones and lipopeptides: from self-assembly to therapeutic applications.
abstract: This review describes the properties and activities of lipopeptides and peptide hormones and how the lipidation of peptide hormones could potentially produce therapeutic agents combating some of the most prevalent diseases and conditions. The self-assembly of these types of molecules is outlined, and how this can impact on bioactivity. Peptide hormones specific to the uptake of food and produced in the gastrointestinal tract are discussed in detail. The advantages of lipidated peptide hormones over natural peptide hormones are summarised, in terms of stability and renal clearance, with potential application as therapeutic agents. © 2017 The Authors Journal of Peptide Science published by European Peptide Society and John Wiley & Sons Ltd.
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Hutchinson
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: S
authors.initials: S
authors.lastname: Burholt
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors.forename: I W
authors.initials: IW
authors.lastname: Hamley
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods*; D004435:Eating / Q000187:drug effects; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D055666:Lipopeptides / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000627:therapeutic use; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D036361:Peptide Hormones / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000627:therapeutic use; D055550:Protein Stability; D017433:Protein Structure, Secondary; D059748:Proteolysis; D013329:Structure-Activity Relationship
chemical_list: D055666:Lipopeptides; D036361:Peptide Hormones
keywords: bioactivity; lipopeptides; peptide; peptide hormones; self-assembly; therapeutics