title: Evaluating Effect of Albendazole onTrichuris trichiuraInfection: A Systematic Review Article.
abstract: BACKGROUND
  The aim of the study was assessment of defaults and conducted meta-analysis of the efficacy of single-dose oral albendazole againstT. trichiurainfection.
  
  
  METHODS
  We searched PubMed, ISI Web of Science, Science Direct, the Cochrane Central Register of Controlled Trials, and WHO library databases between 1983 and 2014. Data from 13 clinical trial articles were used. Each article was included the effect of single oral dose (400 mg) albendazole and placebo in treating two groups of patients withT. trichiurainfection. For both groups in each article, sample size, the number of those withT. trichiurainfection, and the number of those recovered following the intake of albendazole were identified and recorded. The relative risk and variance were computed. Funnel plot, Beggs and Eggers tests were used for assessment of publication bias. The random effect variance shift outlier model and likelihood ratio test were applied for detecting outliers. In order to detect influence, DFFITS values, Cook's distances and COVRATIO were used. Data were analyzed using STATA and R software.
  
  
  RESULTS
  The article number 13 and 9 were outlier and influence, respectively. Outlier is diagnosed by variance shift of target study in inferential method and by RR value in graphical method. Funnel plot and Beggs test did not show the publication bias (P=0.272). However, the Eggers test confirmed it (P=0.034). Meta-analysis after removal of article 13 showed that relative risk was 1.99 (CI 95% 1.71 - 2.31).
  
  
  CONCLUSIONS
  The estimated RR and our meta-analyses show that treatment ofT. trichiurawith single oral doses of albendazole is unsatisfactory. New anthelminthics are urgently needed.
authors.affiliation: Clinical Research Development Center, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Toraj
authors.initials: T
authors.lastname: Ahmadi Jouybari
authors.affiliation: Clinical Research Development Center, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Khadije
authors.initials: K
authors.lastname: Najaf Ghobadi
authors.affiliation: Clinical Research Development Center, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Bahare
authors.initials: B
authors.lastname: Lotfi
authors.affiliation: Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Alavi Majd
authors.affiliation: Department of Medical Lab Technology, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Nayeb Ali
authors.initials: NA
authors.lastname: Ahmadi
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rostami-Nejad
authors.affiliation: Clinical Research Development Center, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Aghaei
keywords: Albendazole; Meta-analysis; Trichuris trichiura