title: Nebulized Liposomal Amphotericin B for Treatment of Pulmonary Infection Caused by Hormographiella aspergillata: Case Report and Literature Review.
abstract: Invasive fungal infection is a serious complication following allogeneic hematopoietic stem cell transplantation. Pulmonary infection due to Hormographiella aspergillata is an uncommon condition associated with a high mortality rate. The susceptibility of H. aspergillata to available antifungal agents is not well established. We report for the first time a case of H. aspergillata lung infection that responded poorly to conventional treatment with liposomal amphotericin B (LAmB; 3 mg kg-1of body weight per day) with renal damage at higher posology (5 mg kg-1of body weight per day), but improved rapidly after addition of nebulized LAmB to intravenous LAmB (3 mg kg-1of body weight per day). Successful treatment of our patient using nebulized LAmB would be worth evaluating in cases refractory to standard treatment or when the reference treatment may not be extended due to interaction or side effects.
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France. c.godet@chu-poitiers.fr.|Service des Maladies Infectieuses et Tropicales, CHU de Poitiers, 86021, Poitiers Cedex, France. c.godet@chu-poitiers.fr.
authors.forename: Cendrine
authors.identifier: http://orcid.org/0000-0003-1433-686X
authors.initials: C
authors.lastname: Godet
authors.affiliation: faculté de médecine et de Pharmacie, Université de Poitiers, 6 rue de la Milétrie, Poitiers, France.|Laboratoire de Parasitologie-Mycologie, CHU Poitiers, 86000, Poitiers, France.
authors.forename: Estelle
authors.initials: E
authors.lastname: Cateau
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France.|faculté de médecine et de Pharmacie, Université de Poitiers, 6 rue de la Milétrie, Poitiers, France.|Inserm U1070, 6 rue de la Milétrie, Poitiers, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Rammaert
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Grosset
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France.
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Le Moal
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France.|EA2694, Université Droit et Santé Lille 2, Lille, France.|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Béraud
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France.
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Martellosio
authors.affiliation: Service de Parasitologie-Mycologie, CHU Toulouse, Toulouse, France.|Centre de Physiopathologie de Toulouse Purpan, INSERM UMR U1043, CNRS UMR 5282, Université de Toulouse, Toulouse, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Iriart
authors.affiliation: Service de Pneumologie, AP-HP, Hôpital Tenon, Paris, France.|Sorbonne Université, UPMC Université Paris 06, 75970, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Cadranel
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000, Poitiers, France.|faculté de médecine et de Pharmacie, Université de Poitiers, 6 rue de la Milétrie, Poitiers, France.|Laboratoire de Parasitologie-Mycologie, CHU Poitiers, 86000, Poitiers, France.
authors.forename: France
authors.initials: F
authors.lastname: Roblot
mesh_terms: D000280:Administration, Inhalation; D061605:Administration, Intravenous; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage*; D000363:Agaricales / Q000302:isolation & purification*; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B
keywords: Hormographiella aspergillata; Lung; Nebulized liposomal amphotericin B; Treatment outcome