title: Difference of coronary stenosis severity between systolic and diastolic phases in quantitative CT angiography.
abstract: BACKGROUND
  To compare the difference of coronary diameter stenosis by quantitative analysis of CT angiography (QCT) in the systolic (QCT-S) and diastolic phase (QCT-D) of the cardiac cycle, with invasive catheter angiography (QCA) as reference standard.
  
  
  METHODS
  A total of 109 patients (57.5 ± 10.6 years, 78.9% male) with suspected coronary artery disease (CAD) who underwent both CT angiography and invasive catheter angiography were retrospectively included in this study. Coronary diameter stenoses in systolic and diastolic coronary CTA reconstructions were compared with QCA.
  
  
  RESULTS
  Mean time interval between CT angiography and invasive angiography was 17.4 ± 4.4 days. QCT-D overestimated coronary diameter stenosis by 5.7%-8.5% while QCT-S overestimated coronary diameter stenosis by 9.4%-11.9% (p < 0.05). In calcified lesions, QCT-D overestimated coronary diameter stenosis by 13.2 ± 4.3%, while QCT-S overestimated by stenosis by 16.6 ± 4.3% (p < 0.05).
  
  
  CONCLUSIONS
  Coronary diameter stenosis was overestimated by QCT-D as well as QCT-S, respectively, when compared with QCA. Overestimation was more pronounced in calcified lesions.
authors.affiliation: Department of CT, Shandong Medical Imaging Research Institute, Shandong University, #324 Jingwu Road, Jinan, 250021, PR China; Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
authors.forename: Zhennan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of CT, Shandong Medical Imaging Research Institute, Shandong University, #324 Jingwu Road, Jinan, 250021, PR China. Electronic address: wangximing_369@sina.com.
authors.forename: Ximing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China. Electronic address: bluvip@126.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
mesh_terms: D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003971:Diastole; D005260:Female; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013599:Systole; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D003287:Contrast Media; D007472:Iohexol
keywords: CT angiography; Invasive catheter angiography; Plaque compositions; Quantitative analysis; Systolic phase and diastolic phase