title: Occurrence of equine coital exanthema (ECE) in stallions in Japan and effectiveness of treatment with valacyclovir for ECE.
abstract: Equine coital exanthema (ECE) has been reported in many countries, but equine herpesvirus 3 (EHV-3) has been isolated only once in Japan. In 2015, symptoms of ECE were found, and EHV-3 was isolated in two stallions. Valacyclovir, an anti-herpesvirus agent, was administered orally. The stallions rested from mating for more than two weeks, causing enormous financial losses because of their high fees. This is the first study in which valacyclovir was administered for ECE. Though valacyclovir treatment did not shorten the duration of healing, the affected area did not expand after administration of valacyclovir. Valacyclovir therefore seems to be effective for suppression of EHV-3 infection. Further investigation about the administration protocol might be required.
authors.affiliation: Shadai Stallion Station, 275 Hayakita-Genbu, Abira-cho, Yufutsu-gun, Hokkaido 059-1501, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Toishi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsunoda
authors.forename: Rikio
authors.initials: R
authors.lastname: Kirisawa
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D005076:Exanthema / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D004858:Herpesvirus 3, Equid / Q000302:isolation & purification*; D006734:Horse Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D006736:Horses; D007564:Japan; D008297:Male; D015229:Sexually Transmitted Diseases, Viral / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir