title: [Strategy for Unresectable Pancreatic Cancer with Stenosis of the Duodenum - A Case Report].
abstract: Unresectable(UR)pancreatic cancer often causes duodenal obstruction. Case 1: A 58-year-old man was diagnosed with UR pancreatic cancer with obstruction of the 3rd duodenal portion. A duodenum 2nd portion jejunum bypass was performed, and FOLFIRINOX was introduced and continued over 6 months. Case 2: A 74-year-old man was diagnosed with UR pancreatic cancer with obstruction of the duodenum near the Treitz ligament. A duodenum 3rd portion jejunum bypass was performed, and gemcitabine plus nab-paclitaxel was introduced. After 8 courses of GN, adjuvant surgery was performed. Both patients resumed oral intake within a few days after bypass, their performance statuses(PS)were improved, and their body weights increased. Because a duodenal jejunum bypass is more physiological than a gastro-jejunum bypass and duodenal stent, stable ingestion is enabled, and they are stable enough for early initiation of chemotherapy.
authors.affiliation: Dept. of Hepato-Biliary-Pancreatic Surgery, Saitama Medical Center, Saitama Medical University.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Komagome
authors.forename: Riki
authors.initials: R
authors.lastname: Ninomiya
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mitsui
authors.forename: Akira
authors.initials: A
authors.lastname: Maki
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ozawa
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Beck
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004380:Duodenal Obstruction / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome