title: A simplified and scalable synthesis of artesunate.
abstract: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH4-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents.
authors.affiliation: Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.
authors.forename: Armin
authors.identifier: 0000-0003-0845-750X
authors.initials: A
authors.lastname: Presser
authors.affiliation: Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Feichtinger
authors.affiliation: Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.
authors.forename: Silke
authors.initials: S
authors.lastname: Buzzi
keywords: Antimalarial; Green chemistry; Natural products; Peroxides; Reductions