title: Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt/β-catenin signaling.
abstract: Non-small cell lung cancer (NSCLC) is one of the most common and aggressive tumors around the world. Long-noncoding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes including tumor progression. However, the role of lncRNA FOXD2-AS1 in NSCLC remains unclear. In this study, we found that lncRNA FOXD2-AS1 is significantly up-regulated in NSCLC tissues. Loss- and gain-function assays revealed that FOXD2-AS1 promotes NSCLC cell growth and NSCLC tumor progression. Furthermore, we also revealed that FOXD2-AS1 modulates Wnt/β-catenin signaling in NSCLC cells. Taken together, we conclude that lncRNA FOXD2-AS1 promotes NSCLC progression though Wnt/β-catenin signaling. These results suggest that lncRNA FOXD2-AS1 might act as a novel therapeutic target for NSCLC treatment.
authors.affiliation: Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Rong
authors.affiliation: Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, China.
authors.forename: Ruixing
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, China. Electronic address: wchqba@163.com.
authors.forename: Jinxiu
authors.initials: J
authors.lastname: Lu
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology*; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008807:Mice, Inbred BALB C; D009361:Neoplasm Invasiveness; D062085:RNA, Long Noncoding / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D015854:Up-Regulation; D060449:Wnt Signaling Pathway
chemical_list: D062085:RNA, Long Noncoding; C000619855:long non-coding RNA FOXD2-AS1, human
keywords: FOXD2-AS1; NSCLC; Wnt/β-catenin signaling; lncRNA