title: Second primary malignancies in patients treated for gastric mucosa-associated lymphoid tissue lymphoma.
abstract: To assess the risk of second primary malignancy (SPM) in patients with gastric mucosa-associated lymphoid tissue (MALT) Lymphoma (GML), we included 175 patients with GML in the present study. The incidence of SPM in the general population, used for reference, was determined from the French network of cancer registries. During the 1442.9 patient-years of follow-up, 29 patients were diagnosed with incident SPM, including five patients diagnosed with gastric cancer (20.1/1000 patient-years). An increased incidence of SPM was observed in patients with GML (standardized incidence ratios [SIR]: 1.71 [1.14-2.45]) compared to the general French population especially for gastric cancer (SIR: 16.1 [5.19-37.56]). This elevated risk of SPM was significantly increased only in patients treated with immuno/chemotherapy but not in patients treated with Helicobacter pylori eradication alone. Long-term follow-up of patients with GML is mandatory even in patients who have achieved complete remission.
authors.affiliation: a Department of Gastroenterology , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.|b Faculté de Médecine , Université Paris Est-Creteil (UPEC) , Creteil , France.|c EC2M3-EA7375 unit , Creteil , France.
authors.forename: Aurelien
authors.initials: A
authors.lastname: Amiot
authors.affiliation: d Digestive Cancer Registry of Burgundy , University Hospital of Dijon, University of Burgundy, INSERM, U866 , Dijon , France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Jooste
authors.affiliation: a Department of Gastroenterology , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.|b Faculté de Médecine , Université Paris Est-Creteil (UPEC) , Creteil , France.|c EC2M3-EA7375 unit , Creteil , France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Gagniere
authors.affiliation: a Department of Gastroenterology , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.
authors.forename: Michaël
authors.initials: M
authors.lastname: Lévy
authors.affiliation: b Faculté de Médecine , Université Paris Est-Creteil (UPEC) , Creteil , France.|e Department of Pathology , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.|f Unit UMR-S 955, INSERM , Creteil , France.
authors.forename: Christiane
authors.initials: C
authors.lastname: Copie-Bergman
authors.affiliation: g Lymphoid Malignancies Unit , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.
authors.forename: Jehan
authors.initials: J
authors.lastname: Dupuis
authors.affiliation: a Department of Gastroenterology , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Le Baleur
authors.affiliation: g Lymphoid Malignancies Unit , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.
authors.forename: Karim
authors.initials: K
authors.lastname: Belhadj
authors.affiliation: a Department of Gastroenterology , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.
authors.forename: Iradj
authors.initials: I
authors.lastname: Sobhani
authors.affiliation: b Faculté de Médecine , Université Paris Est-Creteil (UPEC) , Creteil , France.|f Unit UMR-S 955, INSERM , Creteil , France.|g Lymphoid Malignancies Unit , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Haioun
authors.affiliation: d Digestive Cancer Registry of Burgundy , University Hospital of Dijon, University of Burgundy, INSERM, U866 , Dijon , France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Bouvier
authors.affiliation: a Department of Gastroenterology , Groupe Hospitalier Henri Mondor-Albert Chennevier, APHP , Creteil , France.|b Faculté de Médecine , Université Paris Est-Creteil (UPEC) , Creteil , France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Delchier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects; D015994:Incidence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy
keywords: MALT; alkylating agents; rituximab; rituximab plus chlorambucil; t(11;18) translocation