title: Diverse Profiles of Anxiety Related Disorders in Fragile X, Cornelia de Lange and Rubinstein-Taybi Syndromes.
abstract: Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous aetiology. In this study, we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and (a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales (b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and (c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.
authors.affiliation: Centre for Research in Psychology, Behaviour and Achievement, Coventry University, James Starley Building (JSG12), Priory Street, Coventry, CV1 5FB, UK. hayley.crawford@coventry.ac.uk.|Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. hayley.crawford@coventry.ac.uk.
authors.forename: Hayley
authors.identifier: http://orcid.org/0000-0002-1147-7029
authors.initials: H
authors.lastname: Crawford
authors.affiliation: Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Waite
authors.affiliation: Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Oliver
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D002648:Child; D003635:De Lange Syndrome / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D008297:Male; D012415:Rubinstein-Taybi Syndrome / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D055815:Young Adult
keywords: Anxiety; Cornelia de Lange syndrome; Fragile X syndrome; Genetic syndromes; Intellectual disability; Rubinstein–Taybi syndrome