title: Morning blood pressure surge and arterial stiffness in newly diagnosed hypertensive patients.
abstract: OBJECTIVE
  We aimed to investigate the relationship between the morning blood pressure (BP) surge and arterial stiffness in patients with newly diagnosed hypertension.
  
  
  METHODS
  Three hundred and twenty four (mean age 51.7 ± 11.4 years) patients who had newly diagnosed hypertension with 24 h ambulatory BP monitoring were enrolled. Parameters of arterial stiffness, pulse wave velocity and augmentation index (Aix) were measured by applanation tonometry and aortic distensibility was calculated by echocardiography.
  
  
  RESULTS
  Compared with the other groups, pulse wave velocity, day-night systolic BP (SBP) difference (p < 0.001, for all) and hs-CRP (p = 0.005) were higher in morning BP surge high group. Aortic distensibility values were significantly lower in morning BP surge high group compared to the other groups (p < 0.05, for all). Morning BP surge was found to be independently associated with pulse wave velocity (β = 0.286, p < 0.001), aortic distensibility (β= -0.384, p < 0.001) and day-night SBP difference (β = 0.229, p < 0.001) in multivariate linear regression analysis.
  
  
  CONCLUSIONS
  We found independent relationship between morning BP surge and arterial stiffness which is a surrogate endpoint for cardiovascular diseases. The inverse relationship between morning BP surge and aortic distensibility and direct relation found in our study is new to the literature.
authors.affiliation: a Department of Cardiology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kıvrak
authors.affiliation: a Department of Cardiology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Özbiçer
authors.affiliation: a Department of Cardiology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Gülhan Yüksel
authors.initials: GY
authors.lastname: Kalkan
authors.affiliation: a Department of Cardiology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
mesh_terms: D000328:Adult; D001011:Aorta / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
keywords: Hypertension; ambulatory blood pressure monitoring; arterial stiffness; morning blood pressure surge