title: Association of CAA and TATC Insertion/Deletion Genetic Polymorphisms in RTN4 3'-UTR with Hepatocellular Carcinoma Risk.
abstract: Evidence from recent researchers suggested that RTN4 is a multifunctional gene, including tumor suppression, apoptosis, vascular remodeling, and inhibition of axonal regeneration. The CAA and TATC insertion/deletion polymorphisms (CAA/TATC polymorphisms) of RTN4 3″-untranslated regions (UTRs) have been linked to cervical squamous cell carcinoma (CSCC), uterine leiomyomas (UL) and non-small cell lung cancer (NSCLC). However, the association between these two polymorphisms sites with Hepatocellular Carcinoma (HCC) risk was not carry out before. A total of 284 HCC patients and 484 control subjects were recruited for this study. The RTN4 CAA/TATC insertion/deletion genotypes were determined using polymerase chain reaction (PCR) assay. The ID/DD genotypes of CAA were significantly associated with an increased risk of HCC compared with the II genotype (ID vs. II: OR = 1.50, 95% CI: 1.10-2.04; DD vs. II: OR = 2.00, 95%CI: 1.15-3.46). Meanwhile, the frequency of D allele of CAA was significantly related with an increased risk of HCC compared with the I allele (D vs. I: OR = 1.39, 95% CI: 1.12-1.73). The ID genotypes of TATC was significantly associated with an increased risk of HCC compared with the DD genotype (ID vs. DD: OR = 1.70, 95% CI: 1.23-2.33). The present study provided evidence that RTN4 CAA/TATC polymorphisms were associated with HCC development in Chinese Han population.
authors.affiliation: School of Medical Laboratory Science, Chengdu Medical College, Chengdu, 610500, China.
authors.forename: NaNa
authors.initials: N
authors.lastname: Wang
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, 610500, China.
authors.forename: KeYu
authors.initials: K
authors.lastname: Chen
authors.affiliation: School of Medical Laboratory Science, Chengdu Medical College, Chengdu, 610500, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yuan
authors.affiliation: Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: HongYu
authors.initials: H
authors.lastname: Li
authors.affiliation: Development and Regeneration Key Laboratory of Sichuan Province, Department of Neurobiology, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, 610500, China.
authors.forename: FengMei
authors.initials: F
authors.lastname: Deng
authors.affiliation: Development and Regeneration Key Laboratory of Sichuan Province, Department of Neurobiology, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, 610500, China. zhangls2012@163.com.
authors.forename: LuShun
authors.initials: L
authors.lastname: Zhang
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D000070798:Nogo Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D012307:Risk Factors; D017384:Sequence Deletion
chemical_list: D020413:3' Untranslated Regions; D014408:Biomarkers, Tumor; D000070798:Nogo Proteins; C000603199:RTN4 protein, human
keywords: Hepatocellular carcinoma; Nogo; Polymorphisms; RTN4