title: Successful treatment of pulmonary injury after nitrogen oxide exposure with corticosteroid therapy: A case report and review of the literature.
abstract: Nitrogen oxides are representative chemicals of occupational and environmental exposure, which can lead to fatal pulmonary injury. These oxides are also known to cause delayed occurrence of bronchiolitis obliterans (BO). Herein, we report a case of nitrogen oxide-induced lung injury. A 50-year-old man developed pulmonary edema after nitric acid exposure. Hypoxemia and respiratory failure were immediately improved after introduction of corticosteroid pulse therapy with supplemental oxygen. This was followed by administration of oral prednisolone, and delayed BO did not develop. This case supports the therapeutic efficacy of corticosteroids against pulmonary injury and late-onset BO after nitrogen oxide exposure.
  Prolonged oral prednisolone might be a potential therapy to prevent delayed onset of bronchiolitis obliterans after nitric acid exposure.
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan; Department of Biomedical Chemistry, Graduate School of Medicine, University of Tokyo, Japan.
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Kido
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Mitani
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Isago
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takeshima
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Narumoto
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Goh
authors.initials: G
authors.lastname: Tanaka
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamauchi
authors.affiliation: Department of Clinical Laboratory, The University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Daiya
authors.initials: D
authors.lastname: Takai
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Ohishi
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo Hospital, Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Nagase