title: miR-506 suppresses neuroblastoma metastasis by targeting ROCK1.
abstract: Neuroblastoma is a complex form of cancer with highly heterogeneous clinical behavior that arises during childhood from precursor cells of the sympathetic nervous system. In patients with neuroblastoma, mortality often occurs as a result of metastasis. The disease predominantly spreads to bone marrow, with a survival rate of ~40%. The current study demonstrates that microRNA (miR)-506 directly targets and downregulates Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) in transforming growth factor (TGF)-β non-canonical pathways. It may be concluded that ROCK1 contributes to the invasion and migration of neuroblastoma cells by directly downregulating miR-506; thus, leading to the upregulation of ROCK1, which promotes cell invasion and migration. The present results provide a novel understanding of how miR-506 directly regulates TGF-β non-canonical signaling.
authors.affiliation: Department of Pediatric Surgery, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
authors.forename: Dianguo
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Pediatrics, General Hospital of Jinan Command, Jinan, Shandong 250031, P.R. China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Pediatric Surgery, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pediatric Surgery, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
authors.forename: Jialong
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Pediatric Surgery, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Pediatric Surgery, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Sun
keywords: ROCK1; metastasis; miR-506; neuroblastoma