title: A case of pediatric multiple sclerosis presenting with a tumefactive demyelinating lesion.
abstract: Pediatric multiple sclerosis accompanied by a tumefactive demyelinating lesion (TDL) is extremely rare. Because it is very difficult to distinguish TDLs from neoplasms, invasive brain biopsies are required for a definitive diagnosis. MR spectroscopy (MRS) without brain biopsy was recently shown diagnostic in some patients with TDLs, based on the elevation of glutamate/glutamine peaks. This report describes the clinical course of a 9-year-old girl with multiple sclerosis following a TDL and discusses the usefulness of MRS and brain biopsies to diagnose TDLs.
authors.affiliation: Department of Pediatrics, Toyohashi Municipal Hospital.
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Majima
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ito
authors.forename: Norihisa
authors.initials: N
authors.lastname: Koyama
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D003711:Demyelinating Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005971:Glutamates; D005973:Glutamine; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology
chemical_list: D005971:Glutamates; D005973:Glutamine