title: Clinicopathological importance of anterior prostate cancer in Japanese Men.
abstract: Prostate cancer of transition zone origin or anterior location has been recognized as infrequent, smaller in size and indolent, whereas, our previous report showed that transition zone/anterior cancer was frequently experienced in Japanese men. The current study was conducted to show clinicopathological characteristics of transition zone/anterior cancer. A total of 201 radical prostatectomy specimens were categorized as cancer of anterior or posterior prostate where more than two thirds of the tumor existed in the specific area. Clinicopathological characteristics including Gleason score, pathological stage, lymph node metastasis, extraprostatic extension, surgical incision into the prostate (shown as pT2+), and surgical margin status were compared between anterior and posterior cases. Cases were divided as 83, 73, and 45 of anterior, posterior cancer, and no dominance, respectively. Anterior cancers included significant numbers of high grade tumors (13/83 cases: 15.7%), which was less than posterior cancers (28.8%: 21/73). The cases in pT2+ were significantly more frequent in anterior cases than posterior ones (22.9% vs. 4.1%). No seminal vesicle invasion was shown in anterior cases. Thus, although anterior cancers are less aggressive than posterior cancers, a significant numbers of clinically important cancers were located in the anterior portion in Japanese men.
authors.affiliation: Department of Pathology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan.
authors.forename: Shun
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Pathology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Urology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Urology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Egawa
authors.affiliation: Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523 Japan.
authors.forename: Bungo
authors.initials: B
authors.lastname: Furusato
authors.affiliation: Department of Pathology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ikegami
mesh_terms: D000368:Aged; D044466:Asian People; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000473:pathology*
keywords: Gleason score; prostate cancer; surgical pathology; transition zone; tumor location