title: [A Case of Pathological Complete Response after Neoadjuvant Chemotherapy(S-1 plus Oxaliplatin)and Laparoscopic Low Anterior Resection for Rectal Cancer].
abstract: We report a case of pathological complete response after neoadjuvant chemotherapy(NAC)(S-1 plus oxaliplatin)for rectal cancer. The patient was a 50-year-old man who had type 3 circumferential rectal cancer. An abdominal CT scan revealed locally advanced rectal cancer(cT3N2H0P0M0, cStage III b)with severe stenosis and oral-side intestinal dilatation. The patient was treated with NAC after loop-ileostomy. After 3 courses of chemotherapy, a CT scan revealed significant tumor reduction. Laparoscopic low anterior resection and bilateral lymph node dissection were performed 5 weeks after the last course of chemotherapy. The pathological diagnosis was a pathological complete response(no residual cancer cells). This case suggests that laparoscopic low anterior resection after NAC with S-1 plus oxaliplatin for locally advanced rectal cancer is a potentially effective procedure.
authors.affiliation: Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.
authors.forename: Daichi
authors.initials: D
authors.lastname: Ichinohe
authors.forename: Hajime
authors.initials: H
authors.lastname: Morohashi
authors.forename: Satoko
authors.initials: S
authors.lastname: Umetsu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoshida
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Wakasa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Odagiri
authors.forename: Toshirou
authors.initials: T
authors.lastname: Kimura
authors.forename: Akiko
authors.initials: A
authors.lastname: Suto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saito
authors.forename: Eri
authors.initials: E
authors.lastname: Yoshida
authors.forename: Harue
authors.initials: H
authors.lastname: Akasaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Jin
authors.forename: Takuya
authors.initials: T
authors.lastname: Miura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology / Q000601:surgery; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D010094:Oxonic Acid / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid