title: Specific imaging characteristic of solitary necrotic nodule of the liver: Marked peripheral rim-like enhancement with internal hypointensity on longer delayed MRI.
abstract: OBJECTIVE
  To obtain specific imaging findings of solitary necrotic nodule of the liver (SNNL) using longer delayed contrast-enhanced MRI and compare them with those of three mimic hepatic diseases.
  
  
  METHODS
  Sixteen patients with SNNL underwent plain and contrast-enhanced triphasic CT and multiphasic MRI with delayed time prolonged to 2 h after contrast bolus injection. Twenty-three patients with mimic lesions including seven with eight HCCs, five with five iCCs and 11 with metastatic lesions served as the control group. Those patients also received plain and multiphasic contrast-enhanced MRI. Imaging features of lesions such as peripheral wash-out time were evaluated.
  
  
  RESULTS
  Among the 16 SNNLs, with a prolonged delayed MRI time, the enhancement degree of tumour periphery increased gradually. When it was up to 1 h, all lesions represented moderate/marked peripheral enhancement with internal hypointensity. However, the peripheral wash-out in seven HCCs (87.5%) and all metastatic lesions except three appeared at 10 or 15 min, one iCC (20%) at 30 min and the other lesions at 1 h.
  
  
  CONCLUSIONS
  Longer MRI with a delayed time of 1-2 h may be useful in diagnosis SNNL, revealing the specific imaging characteristic of SNNL as pronounced peripheral enhancement with internal hypointensity.
  
  
  CONCLUSIONS
  • Longer delayed MRI plays an important role in the diagnosis of SNNL. • Characteristic imaging feature of SNNL is pronounced peripheral enhancement with internal hypointensity. • Periphery wash-out time can differentiate SNNL from mimic diseases. • Imaging findings of SNNL on routine CT and MRI are unspecific.
authors.affiliation: Department of Radiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Ji'nan City, Shandong, China, 250012.
authors.forename: Jiayang
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Ji'nan City, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Radiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Ji'nan City, Shandong, China, 250012. yudexin0330@sina.com.
authors.forename: Dexin
authors.initials: D
authors.lastname: Yu
authors.affiliation: Department of Radiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Ji'nan City, Shandong, China, 250012.
authors.forename: Xiangxing
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Radiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Ji'nan City, Shandong, China, 250012.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Department of Radiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Ji'nan City, Shandong, China, 250012.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media
keywords: Hepatic metastasis; Hepatocellular carcinoma; Imaging findings; Intrahepatic cholangiocarcinoma; Solitary necrotic nodule of the liver