title: [Two Cases of Locally Recurrent Rectal Cancer after Intersphincteric Resection That Were Controlled with a Combination of Chemoradiotherapy and Abdominoperineal Resection].
abstract: We report 2 cases of locally recurrent rectal cancer after intersphincteric resection(ISR)that were controlled with a combination of chemoradiotherapy and abdominoperineal resection(APR). In Case 1, we performed preoperative chemoradiotherapy( TS-1 plus RT 45 Gy)and APR for the local recurrence of ISR. On pathology, viable neoplastic cells were noted. In Case 2, we performed preoperative chemotherapy(Bmab plus mFOLFOX6)and APR for the local recurrence of ISR. On pathology, no viable neoplastic cells were noted. However, a local recurrence developed again 3 months later. Therefore, we performed chemoradiotherapy(TS-1 plus RT 53 Gy). The 2 patients survived without recurrence until now. Their pathology tissues and clinical courses showed that control of local recurrence with only chemoradiotherapy or surgical resection was likely to be difficult. We might be able to improve the prognosis of patients with a combination of chemoradiotherapy and surgical resection.
authors.affiliation: Dept. of Surgery, Hiroshima City Hiroshima Citizens Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Idani
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Takahashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Mimura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ogawa
authors.forename: Soichiro
authors.initials: S
authors.lastname: Miyake
authors.forename: Michihiro
authors.initials: M
authors.lastname: Ishida
authors.forename: Daisuke
authors.initials: D
authors.lastname: Satoh
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Choda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sumitani
authors.forename: Masao
authors.initials: M
authors.lastname: Harano
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Ojima
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Shiozaki
authors.forename: Masazumi
authors.initials: M
authors.lastname: Okajima
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000628:therapy*; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*; D012008:Recurrence; D016896:Treatment Outcome