title: [Long-Term Survival of a Patient with Stage IV Breast Cancer and An Intrathoracic Space-Occupying Metastatic Lesion].
abstract: A 50-year old woman noticed left axillary lymph node swelling and presented at our hospital. CNB showed adenocarcinoma( pap-tub, ER+, PgR+, HER2 3+). CT revealed a right lung metastatic nodule and swollen lymph nodes above the left collarbone and left axilla. However, no breast tumor was found at that time. We diagnosed occult breast cancer, TxN3bM1 (lung), Stage IV . FEC(100), paclitaxel, letrozole, anastrozole, exemestane plus trastuzumab, tegafur/uracil plus trastuzumab, and lapatinib plus capecitabine were sequentially administered. Five years and 9 months after the treatment started, CT revealed a right intrathoracic lesion that had gradually increased in size. Subsequently, trastuzumab plus pertuzumab plus docetaxel, bevacizumab plus paclitaxel, trastuzumab emtansine, trastuzumab plus fulvestrant, and doxifluridine plus medroxyprogesterone acetate plus cyclophosphamide(DMpC therapy)were sequentially administered. At this time, 8 years after the treatment started, trastuzumab plus pertuzumab plus vinorelbine were also administered. An intrathoracic space-occupying lesion due to breast cancer is rare, and anti-HER2 chemotherapy was effective for this patient.
authors.affiliation: Dept. of Surgery, Japan Community Health care Organization Kobe Central Hospital.
authors.forename: Toshimori
authors.initials: T
authors.lastname: Koh
authors.forename: Tomohito
authors.initials: T
authors.lastname: Sakai
authors.forename: Shunji
authors.initials: S
authors.lastname: Kato
authors.forename: Shoji
authors.initials: S
authors.lastname: Hirajima
authors.forename: Minoru
authors.initials: M
authors.lastname: Nishio
authors.forename: Koji
authors.initials: K
authors.lastname: Soga
authors.forename: Atsushi
authors.initials: A
authors.lastname: Oguro
authors.forename: Noboru
authors.initials: N
authors.lastname: Nakagawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D000070602:Rib Cage / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome