title: Prospective Evaluation of Intra-Articular Sodium Hyaluronate Injection in the Ankle.
abstract: Viscosupplementation by injection of hyaluronic acid into the ankle can be used to provide pain relief and to delay the need for surgery in patients with osteoarthritis of the ankle. In the present investigation, we prospectively evaluated 50 consecutive patients (25 males and 25 females) undergoing a 3-injection protocol of sodium hyaluronate viscosupplementation in the ankle from January 2014 to January 2015. The Foot and Ankle Outcomes Score was used to compare the patients' pre- and post-treatment opinions about their ankle problems. The mean pretreatment Foot and Ankle Outcomes Score was 48 ± 6.3 (range 25 to 84) and the 6-month post-treatment score was 78 ± 5.8 (range 48 to 100). This difference was statistically significant (p = .003). From our findings in the present prospective cohort study, we have concluded that intra-articular injection of sodium hyaluronate viscosupplementation is a useful conservative therapy for osteoarthritis of the ankle.
authors.affiliation: Orthopaedic Resident, Department of Trauma and Orthopaedics, Galway University Hospital, Saolta Hospital Group, Galway, Ireland. Electronic address: evelynmurphy@hotmail.com.
authors.forename: Evelyn P
authors.initials: EP
authors.lastname: Murphy
authors.affiliation: Orthopaedic Registrar, Department of Trauma and Orthopaedics, Galway University Hospital, Saolta Hospital Group, Galway, Ireland.
authors.forename: Mark
authors.initials: M
authors.lastname: Curtin
authors.affiliation: Orthopaedic Specialist Registrar, Department of Trauma and Orthopaedics, Galway University Hospital, Saolta Hospital Group, Galway, Ireland.
authors.forename: Niall P
authors.initials: NP
authors.lastname: McGoldrick
authors.affiliation: Orthopaedic Resident, Department of Trauma and Orthopaedics, Galway University Hospital, Saolta Hospital Group, Galway, Ireland.
authors.forename: Gerard
authors.initials: G
authors.lastname: Thong
authors.affiliation: Consultant Surgeon, Department of Trauma and Orthopaedics, Galway University Hospital, Saolta Hospital Group, Galway, Ireland.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Kearns
mesh_terms: D000328:Adult; D000368:Aged; D000843:Ankle Joint / Q000503:physiopathology*; D000072700:Conservative Treatment; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D063868:Patient Outcome Assessment; D011446:Prospective Studies; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid
keywords: Foot and Ankle Outcomes Score; Suplasyn(®); ankle arthritis; conservative treatment; hyaluronic acid; viscosupplementation