title: Phenolic acid derivatives with neuroprotective effect from the aqueous extract of Clerodendranthus spicatus.
abstract: Two new phenolic acid helisterculins C (1) and D (2) were isolated from the whole plant of Clerodendranthus spicatus. Their structures were elucidated on the basis of 1D and 2D NMR, MS, and CD analysis. Compound 1 possesses an unusual bicyclol [2. 2. 2] octane moiety which is rare in the previously isolated phenolic acid derivatives. The two compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells, and the result showed that compounds 1 and 2 displayed moderate neuroprotective activity with the IC50values of 17.4 and 21.3 μM, respectively.
authors.affiliation: a Acupuncture and Moxibustion Department , The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine , Harbin 150009 , China.|b Acupuncture and Moxibustion Department , Harbin Medical University , Harbin 150001 , China.
authors.forename: Hai-Chun
authors.initials: HC
authors.lastname: Zhou
authors.affiliation: c Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin 150040 , China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: d Wenchang Sub Center , Harbin First Aid Center , Harbin 150001 , China.
authors.forename: Rui-Zhu
authors.initials: RZ
authors.lastname: Guo
authors.affiliation: e School Basic Medical Sciences, HUCM , Heilongjiang University of Chinese Medicine , Harbin 150040 , China.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
mesh_terms: D016923:Cell Death / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D009795:Octanes; D016627:Oxidopamine
chemical_list: D004365:Drugs, Chinese Herbal; D062385:Hydroxybenzoates; D018696:Neuroprotective Agents; D009795:Octanes; C000623064:helisterculin C; C000623065:helisterculin D; D016627:Oxidopamine; C017616:phenolic acid; C026728:octane
keywords: Clerodendranthus spicatus; Lamiaceae; helisterculins C and D; neuroprotective activity; phenolic acids