title: Hematopoietic Processes in Eosinophilic Asthma.
abstract: Airway eosinophilia is a hallmark of allergic asthma, and understanding mechanisms that promote increases in lung eosinophil numbers is important for effective pharmacotherapeutic development. It has become evident that expansion of hematopoietic compartments in the bone marrow (BM) promotes differentiation and trafficking of mature eosinophils to the airways. Hematopoietic progenitor cells egress the BM and home to the lungs, where in situ differentiation within the tissue provides an ongoing source of proinflammatory cells. In addition, hematopoietic progenitor cells in the airways can respond to locally derived alarmins to produce a panoply of cytokines, thereby themselves acting as effector proinflammatory cells that potentiate type 2 responses in eosinophilic asthma. In this review, we provide evidence for these findings and discuss novel targets for modulating eosinophilopoietic processes, migration, and effector function of precursor cells.
authors.affiliation: CardioRespiratory Research Group, Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: Brittany M
authors.initials: BM
authors.lastname: Salter
authors.affiliation: CardioRespiratory Research Group, Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: sehmir@mcmaster.ca.
authors.forename: Roma
authors.initials: R
authors.lastname: Sehmi
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D053648:Cytokine Receptor Common beta Subunit / Q000037:antagonists & inhibitors; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology; D004804:Eosinophils / Q000166:cytology / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors; D011657:Pulmonary Eosinophilia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D012130:Respiratory Hypersensitivity / Q000209:etiology / Q000503:physiopathology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D053648:Cytokine Receptor Common beta Subunit; D016207:Cytokines; D008565:Membrane Proteins; C584197:TMEM102 protein, human; D000094632:Thymic Stromal Lymphopoietin
keywords: airway inflammation; allergic asthma; asthma; bone marrow