title: [Surgical Resection after Gemcitabine plus Cisplatin Chemotherapy for Intrahepatic Cholangiocarcinoma with Multiple Lymph Node Metastases - Report of a Case].
abstract: An 82-year-old man with upper abdominal pain was referred to our hospital because of an elevated serum CEA level and dilatation of the intrahepatic bile ducts on ultrasonography.Computed tomography revealed a hypovascular mass measuring 5.0 cm in size in the lateral section, dilatation of the peripheral intrahepatic bile ducts, and swollen lymph nodes around the lesser curvature of the stomach, the common hepatic artery, and the paraaorta.He was diagnosed with unresectable intrahepatic cholangiocarcinoma, and he received chemotherapy with biweekly gemcitabine plus cisplatin.After 33 courses of the chemotherapy, computed tomography revealed that the tumor size decreased over 63%, and all swollen lymph nodes had almost resolved.He underwent a left hemihepatectomy 1 year 6 months after the start of the chemotherapy.He remains alive and well with no evidence of recurrence, 11 months after resection.
authors.affiliation: Dept. of Surgery, Akita Kosei Medical Center.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Otani
authors.forename: Jun
authors.initials: J
authors.lastname: Sakata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kameyama
authors.forename: Ayaka
authors.initials: A
authors.lastname: Otani
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamura
authors.forename: Yuta
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Miura
authors.forename: Kei
authors.initials: K
authors.lastname: Yoshino
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kido
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Endo
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Wakai
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000601:surgery; D018281:Cholangiocarcinoma / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006498:Hepatectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020360:Neoadjuvant Therapy; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine