title: Reducing the prevalence of dysglycemia: is the time ripe to test the effectiveness of intervention in high-risk individuals with elevated 1 h post-load glucose levels?
abstract: Identifying the earliest time point on the prediabetic continuum is critical to avoid progressive deterioration in β-cell function. Progressively rising glucose levels even within the "normal range" occur considerably late in the evolution to diabetes thus presenting an important opportunity for earlier diagnosis, treatment, and possible reversal. An elevated 1 h postprandial glucose level, not detected by current diagnostic standards, may provide an opportunity for the early identification of those at risk. When the 1 h post-load glucose level is elevated, lifestyle intervention may have the greatest benefit for preserving β-cell function and prevent further progression to prediabetes and diabetes. In view of the considerable consistent epidemiologic data in large disparate populations supporting the predictive capacity of the1 h post-load value for predicting progression to diabetes and mortality, the time is therefore ripe to evaluate this hypothesis in a large, prospective multicenter randomized trial with lifestyle intervention.
authors.affiliation: NYU School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, NYU Langone Diabetes Prevention Program, New York, NY, 10016, USA. michael.bergman@nyumc.org.
authors.forename: Michael
authors.initials: M
authors.lastname: Bergman
authors.affiliation: NYU School of Medicine, Department of Population Health, Division of Health Behavior Change, New York, NY, 10016, USA.
authors.forename: Ram
authors.initials: R
authors.lastname: Jagannathan
authors.affiliation: Department of Endocrinology and Diabetology, Université Catholique de Louvain, University Clinic Saint-Luc, Brussels, Belgium.
authors.forename: Martin
authors.initials: M
authors.lastname: Buysschaert
authors.affiliation: Oporto Medical School, Oporto University, Oporto, Portugal.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Medina
authors.affiliation: NYU School of Medicine, Department of Population Health, Division of Health Behavior Change, New York, NY, 10016, USA.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Sevick
authors.affiliation: NYU School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, NYU Langone Diabetes Prevention Program, New York, NY, 10016, USA.
authors.forename: Karin
authors.initials: K
authors.lastname: Katz
authors.affiliation: NYU School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, NYU Langone Diabetes Prevention Program, New York, NY, 10016, USA.
authors.forename: Brenda
authors.initials: B
authors.lastname: Dorcely
authors.affiliation: The Feinstein Institute for Medical Research, Manhasset, North Shore, New York, 11030, USA.
authors.forename: Jesse
authors.initials: J
authors.lastname: Roth
authors.affiliation: Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, 52621, Israel.
authors.forename: Angela
authors.initials: A
authors.lastname: Chetrit
authors.affiliation: The Feinstein Institute for Medical Research, Manhasset, North Shore, New York, 11030, USA.|Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, 52621, Israel.|Sackler Faculty of Medicine, School of Public Health, Department of Epidemiology and Preventive Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.
authors.forename: Rachel
authors.initials: R
authors.lastname: Dankner
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D018450:Disease Progression; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D005951:Glucose Tolerance Test; D006801:Humans; D008019:Life Style; D015995:Prevalence
chemical_list: D001786:Blood Glucose
keywords: Diabetes; Diabetes prevention; Dysglycemia; Oral glucose tolerance test; Prediabetes