title: Limited cutaneous systemic sclerosis arising in a patient with Graves' disease.
abstract: Although Graves' disease and systemic sclerosis are both autoimmune disorders, their relationship is rarely reported. We present the case of a Filipino woman with goitre and thyrotoxic signs and symptoms. Diagnosed with Graves' disease at the outpatient clinic, she took antithyroid medications and underwent radioactive iodine ablation with resultant hypothyroidism after 6 months, during which she began to experience skin tightness over the face, neck and fingers. Workup revealed limited cutaneous systemic sclerosis, and the patient improved with methotrexate. This case highlights the increased prevalence of coincident autoimmune disorders in Graves' disease.
authors.affiliation: Department of Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines.
authors.forename: Marc Gregory
authors.identifier: http://orcid.org/0000-0002-0376-9574
authors.initials: MG
authors.lastname: Yu
authors.affiliation: Department of Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines.|Section of Endocrinology, Diabetes and Metabolism, University of the Philippines-Philippine General Hospital, Manila, Philippines.
authors.forename: John Paul Montinola
authors.identifier: http://orcid.org/0000-0002-9527-712X
authors.initials: JP
authors.lastname: Quisumbing
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008713:Methimazole / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D009333:Neck; D045745:Scleroderma, Limited / Q000150:complications* / Q000188:drug therapy; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013956:Antithyroid Agents; D007166:Immunosuppressive Agents; D007457:Iodine Radioisotopes; D008713:Methimazole; D013974:Thyroxine; D008727:Methotrexate