title: Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.
abstract: Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry.
authors.affiliation: Department of Vertebrate Zoology, Faculty of Biology, Saint Petersburg State University, Universitetskaya nab., 7/9, Saint Petersburg 199034, Russia. trulioff@gmail.com.
authors.forename: Andrey
authors.initials: A
authors.lastname: Trulioff
authors.affiliation: Department of Vertebrate Zoology, Faculty of Biology, Saint Petersburg State University, Universitetskaya nab., 7/9, Saint Petersburg 199034, Russia. ermakov99@mail.ru.|Laboratory of Molecular Neurobiology, Department of Ecological Physiology, Institute of Experimental Medicine, ul. Akad. Pavlov, 12, Saint Petersburg 197376, Russia. ermakov99@mail.ru.
authors.forename: Alexander
authors.initials: A
authors.lastname: Ermakov
authors.affiliation: Department of Vertebrate Zoology, Faculty of Biology, Saint Petersburg State University, Universitetskaya nab., 7/9, Saint Petersburg 199034, Russia. y.malashichev@spbu.ru.|Laboratory of Molecular Neurobiology, Department of Ecological Physiology, Institute of Experimental Medicine, ul. Akad. Pavlov, 12, Saint Petersburg 197376, Russia. y.malashichev@spbu.ru.
authors.forename: Yegor
authors.initials: Y
authors.lastname: Malashichev
keywords: DCDC2; Disc1; Dyx1c1; PCM-1; abelson helper integrator 1; centrosome; hamartin; left-right asymmetry; pericentrin; schizophrenia