title: [A Case of Curatively Resected Locally Advanced Cancer of the Pancreatic Body Treated by Distal Pancreatectomy with En Bloc Celiac Axis Resection after Preoperative Intensive Treatment].
abstract: A 70-year-old woman with locally advanced pancreatic body cancer invading the celiac axis underwent 4 courses of preoperative chemotherapy consisting of gemcitabine(GEM)plus nab-paclitaxel(nab-PTX)on days 1, 8, and 15 every 4 weeks, followed by radiation therapy(CRT; 50.4Gy delivered in 28 daily fractions). The tumor size was greatly diminished and levels of all tumor markers were decreased. R0resection by distal pancreatectomy with en bloc celiac axis resection(DP-CAR)was performed. The histopathologic findings showed that the effect of CRT was grade 2b(Evans' classification), and the surgical margins were histologically clear. After the surgery, S-1 was administered continuously. The patient shows no signs of recurrence 1 year after surgery.
authors.affiliation: Dept. of Surgery, Kaizuka City Hospital.
authors.forename: Yongkook
authors.initials: Y
authors.lastname: Kim
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hoshino
authors.forename: Naruyasu
authors.initials: N
authors.lastname: Kakita
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Yohei
authors.initials: Y
authors.lastname: Hosoda
authors.forename: Masaya
authors.initials: M
authors.lastname: Nishino
authors.forename: Miho
authors.initials: M
authors.lastname: Okano
authors.forename: Junji
authors.initials: J
authors.lastname: Kawada
authors.forename: Masaki
authors.initials: M
authors.lastname: Okuyama
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tsujinaka
mesh_terms: D000368:Aged; D000418:Albumins / Q000008:administration & dosage; D002445:Celiac Artery / Q000601:surgery*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D017239:Paclitaxel / Q000008:administration & dosage; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000093542:Gemcitabine
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D003841:Deoxycytidine; D017239:Paclitaxel; D000093542:Gemcitabine