title: The influence of TNF alpha -308 G/A polymorphism on oxidative stress in patients with chronic lymphocytic leukemia.
abstract: The aim of this study was to examine the association of TNF-α-308G/A polymorphism with CLL and influence on oxidative stress parameters.Significant difference in the genotype and allele distribution was obtained in TNFA subgroup of patients.Significantly higher GPx activity and TBARS and lower catalase activity were detected in CLL.Significantly higher catalase and lower GPx activities were detected in PBMC of TNFG compared to TNFA subgroup, while TBARS were higher in TNFA.Oxidative stress in CLL patients highly correlates with the presence of TNFA subgroup. Increased TBARS, GPx and decreased catalase activity are associated with TNF-α-308A allele containing genotypes.
authors.affiliation: University of Nis, Faculty of Medicine, Department of Biochemistry, Nis, Serbia; University of Nis, Faculty of Medicine, Laboratory for Functional Genomics and Proteomics, Nis, Serbia. Electronic address: tjevtovic@yahoo.com.
authors.forename: T
authors.initials: T
authors.lastname: Jevtovic-Stoimenov
authors.affiliation: University of Nis, Faculty of Medicine, Department of Biochemistry, Nis, Serbia.
authors.forename: T
authors.initials: T
authors.lastname: Cvetkovic
authors.affiliation: University of Nis, Faculty of Medicine, Department of Biochemistry, Nis, Serbia; University of Nis, Faculty of Medicine, Laboratory for Functional Genomics and Proteomics, Nis, Serbia.
authors.forename: M
authors.initials: M
authors.lastname: Despotovic
authors.affiliation: University of Nis, Faculty of Medicine, Department of Biochemistry, Nis, Serbia; University of Nis, Faculty of Medicine, Laboratory for Functional Genomics and Proteomics, Nis, Serbia.
authors.forename: J
authors.initials: J
authors.lastname: Basic
authors.affiliation: Institute for treatment and rehabilitation "Niška Banja", Niš, Serbia.
authors.forename: J
authors.initials: J
authors.lastname: Cvetkovic
authors.affiliation: University of Nis, Faculty of Medicine, Clinic for Hematology and Clinical Immunology, Clinical Center, Nis, Serbia.
authors.forename: G
authors.initials: G
authors.lastname: Marjanovic
authors.affiliation: University of Nis, Faculty of Medicine, Department of Biochemistry, Nis, Serbia; University of Nis, Faculty of Medicine, Laboratory for Functional Genomics and Proteomics, Nis, Serbia.
authors.forename: D
authors.initials: D
authors.lastname: Pavlovic
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D005260:Female; D005838:Genotype; D005979:Glutathione Peroxidase / Q000032:analysis; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha; D002374:Catalase; D005979:Glutathione Peroxidase
keywords: CLL; Oxidative stress; TNF-α polymorphism