title: Effect of β-blocker on aneurysm sac behavior after endovascular abdominal aortic repair.
abstract: This study was conducted to determine whether β-blocker (BB) therapy is associated with abdominal aortic aneurysm (AAA) sac regression after endovascular abdominal aortic repair (EVAR).
  
  
  
  A total of 198 patients (mean age, 76 years) who underwent EVAR were analyzed (104 in the BB group and 94 in the non-BB group). The primary end point was the incidence of AAA sac regression at 1 and 2 years.
  
  
  
  Hypertension, coronary artery disease, and hyperlipidemia were more common in the BB group. The BB group was also more likely to have been prescribed an aspirin and a statin than the non-BB group. The length of proximal neck was significantly longer in the non-BB group than in the BB group. All study patients were monitored for at least 1 year after EVAR, and 2-year follow-up was available in 104 patients (52.5%). There was no statistically significant difference in the incidence of aneurysm sac regression in either group at 1 year (52.1% in the non-BB group vs 45.2% in the BB group; P = .330) and 2 years (58.5% in the non-BB group vs 64.7% in the BB group; P = .515). The difference of the change of AAA maximum diameter between two groups did not reach statistical significance at 1 year (-6.0 ± 7.0 mm in the non-BB group vs -5.5 ± 8.1 mm in the BB group; P = .644) and 2 years (-9.0 ± 10.5 mm in the non-BB group vs -9.0 ± 10.0 mm in the BB group; P = .977). BB therapy was not associated with increased odds of AAA sac regression. The effect of third-generation BBs on AAA sac regression was not significant.
  
  
  
  BB therapy had no effect on AAA sac regression. At the present time, there is insufficient evidence to recommend BB therapy for the purpose of AAA sac regression.
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Fla; Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Fla; Division of Cardiology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Republic of Korea.
authors.forename: Wonho
authors.initials: W
authors.lastname: Kim
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Fla.
authors.forename: Ripal T
authors.initials: RT
authors.lastname: Gandhi
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Fla.
authors.forename: Constantino S
authors.initials: CS
authors.lastname: Peña
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Fla.
authors.forename: Raul E
authors.initials: RE
authors.lastname: Herrera
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Fla.
authors.forename: Melanie B
authors.initials: MB
authors.lastname: Schernthaner
authors.affiliation: Division of Vascular Surgery, Miami Cardiac and Vascular Institute, Miami, Fla.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tsoukas
authors.affiliation: Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Fla.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Acuña
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Fla. Electronic address: barryk@baptisthealth.net.
authors.forename: Barry T
authors.initials: BT
authors.lastname: Katzen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D057510:Endovascular Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists