title: Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans.
abstract: To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further compare risk factors between those with typical AMD and polypoidal choroidal vasculoapthy (PCV) subtypes. We recruited 456 cases and 1,824 controls matched for age, gender and ethnicity. Data on systemic and ocular risk factors were collected on questionnaires. In a subgroup of subjects, we included genetic data on four AMD-associated single nucleotide polymorphisms (SNPs). Risk factors for nAMD and subtypes were analyzed. Systemic risk factors for nAMD included older age, male gender, higher BMI and higher HDL-cholesterol. Ocular risk factors included pseudophakic and shorter axial length. Risk factors common to both typical AMD and PCV subtypes included age, BMI and HDL-cholesterol. Shorter axial length was only associated with PCV, while male gender and pseudophakia were only associated with typical AMD. In the subgroup with genotype data, ARMS2 rs10490924 and CFH rs800292 were associated with nAMD. None of the risk factors were significantly different between PCV and typical AMD. Systemic, ocular and genetic risk factors were largely similar for typical AMD and PCV subtypes in this Asian population based in Singapore.
authors.affiliation: Singapore National Eye Centre, Singapore.|Singapore Eye Research Institute, Singapore.|Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Chui Ming Gemmy
authors.initials: CM
authors.lastname: Cheung
authors.affiliation: Singapore Eye Research Institute, Singapore.|Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
authors.forename: Augustinus
authors.initials: A
authors.lastname: Laude
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Ian
authors.initials: I
authors.lastname: Yeo
authors.affiliation: Singapore Eye Research Institute, Singapore.
authors.forename: Shu-Pei
authors.initials: SP
authors.lastname: Tan
authors.affiliation: Singapore Eye Research Institute, Singapore.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Mathur
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Shu Yen
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Choi Mun
authors.initials: CM
authors.lastname: Chan
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Gavin
authors.initials: G
authors.lastname: Tan
authors.affiliation: Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
authors.forename: Tock Han
authors.initials: TH
authors.lastname: Lim
authors.affiliation: Singapore Eye Research Institute, Singapore.
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Singapore National Eye Centre, Singapore.|Singapore Eye Research Institute, Singapore.|Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D020256:Choroidal Neovascularization / Q000150:complications / Q000235:genetics*; D003710:Demography; D005123:Eye / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012846:Singapore