title: [Combination and sequential therapy using bisphosphonates.]
abstract: Bisphosphonates have been explored possible combination and/or sequential use with other anti-osteoporotic medications including PTH. Besides with vitamin D(metabolites), combination treatment had been uncommon mainly because there had not been enough anti-fracture evidence. PTH, which can only be used for a certain period over lifetime, requires other anti-osteoporotic medications after and/or before its use. Bisphosphonates have been tried with PTH in various sequential and/or combination ways. Various combination and/or sequential therapy using bisphosphonates will be reviewed in this article.
authors.affiliation: Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Okazaki
mesh_terms: D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D058866:Osteoporotic Fractures / Q000517:prevention & control
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates