title: Ultrasound-Guided Diffuse Optical Tomography for Differentiation of Benign and Malignant Breast Lesions: A Meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to assess the diagnostic performance of ultrasound-guided diffuse optical tomography for differentiation of benign and malignant breast lesions.
  
  
  METHODS
  The Cochrane Library, PubMed, and Embase databases were searched from inception to February 14, 2016. Sensitivity, specificity, and other information were extracted from the included studies. Sensitivity and specificity were pooled by a bivariate mixed-effects binary regression model. A summary receiver operating characteristic curve was constructed. Heterogeneity and publication bias were explored by Higgins and Deeks tests, respectively.
  
  
  RESULTS
  Seven studies including 768 women with 886 lesions were analyzed. The summary sensitivity, specificity, and diagnostic odds ratio were 95% (95% confidence interval [CI], 85%-98%), 77% (95% CI, 66%-85%), and 57 (95% CI, 12-267), respectively. The area under the summary receiver operating characteristic curve was 91% (95% CI, 89%-94%). No significant heterogeneity or publication bias existed.
  
  
  CONCLUSIONS
  Ultrasound-guided diffuse optical tomography is useful for differentiating breast lesions. Especially, its sensitivity is excellent.
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Jin-Chun
authors.initials: JC
authors.lastname: Feng
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Shabier
authors.initials: S
authors.lastname: Tuerhong
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Jinsihan
authors.initials: J
authors.lastname: Dilixiati
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Xu
authors.affiliation: Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhu
mesh_terms: D001940:Breast / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*; D016217:Ultrasonography, Mammary / Q000379:methods*
keywords: breast tumor; breast ultrasound; diffuse optical tomography; meta-analysis; ultrasound; ultrasound-guided diffuse optical tomography