title: A simple method for calculating the productivity of polyphenol separations by polymer-based chromatography.
abstract: A simple method for calculating the productivity of chromatography processes was proposed based on the iso-resolution curve concept. The model separation system was polyphenol separations by polystyrene divinylbenzene resins with the ethanol-water mixture mobile phase. The distribution coefficient K was determined as a function of ethanol concentration I by linear gradient elution experiments. The HETP-mobile phase velocity u curves were determined as a function of I. Using K and HETP, the iso-resolution curve was calculated, from which the productivity was determined as a function of I. It was found that there is an optimum I, where the highest productivity with the minimum amount of mobile phase consumption is obtained.
authors.affiliation: a Bio-Process Engineering Laboratory, School of Engineering & Graduate School of Medicine, Yamaguchi University Biomedical Engineering Center (YUBEC) , Yamaguchi University , Ube , Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimoto
authors.affiliation: a Bio-Process Engineering Laboratory, School of Engineering & Graduate School of Medicine, Yamaguchi University Biomedical Engineering Center (YUBEC) , Yamaguchi University , Ube , Japan.
authors.forename: Yukiteru
authors.initials: Y
authors.lastname: Sugiyama
authors.affiliation: a Bio-Process Engineering Laboratory, School of Engineering & Graduate School of Medicine, Yamaguchi University Biomedical Engineering Center (YUBEC) , Yamaguchi University , Ube , Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D002852:Chromatography, Ion Exchange; D000431:Ethanol / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry* / Q000302:isolation & purification; D011137:Polystyrenes / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D011108:Polymers; D059808:Polyphenols; D011137:Polystyrenes; D014867:Water; D000431:Ethanol
keywords: distribution coefficient; polymer-resin chromatography; polyphenols; productivity