title: Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach.
abstract: Epidemiology and clinical studies provide clear evidence of the complex links between diet and health. To understand these links, reliable dietary assessment methods are pivotal. Biomarkers have emerged as more objective measures of intake compared with traditional dietary assessment methods. However, there are only a limited number of putative biomarkers of intake successfully identified and validated. The use of biomarkers that reflect food intake to examine diet related diseases represents the next step in biomarker research. Therefore, the aim of this study was to (1) identify and confirm biomarkers associated with dietary fat intake and (2) examine the relationship between those biomarkers with health parameters. Heatmap analysis identified a panel of 22 lipid biomarkers associated with total dietary fat intake in the Metabolic Challenge (MECHE) Study. Confirmation of four of these biomarkers demonstrated responsiveness to different levels of fat intake in a separate intervention study (NutriTech study). Linear regression identified a significant relationship between the panel of dietary fat biomarkers and HOMA-IR, with three lipid biomarkers (C16, PCaaC36:2, and PCae36:4) demonstrating significant associations. Identifying such links allows us to explore the relationship between diet and health to determine whether these biomarkers can be modulated through diet to improve health outcomes.
authors.affiliation: Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Aoife
authors.initials: A
authors.lastname: O'Gorman
authors.affiliation: Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Helena
authors.initials: H
authors.lastname: Gibbons
authors.affiliation: Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Miriam F
authors.initials: MF
authors.lastname: Ryan
authors.affiliation: Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Eileen R
authors.initials: ER
authors.lastname: Gibney
authors.affiliation: Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gibney
authors.affiliation: Department of Medicine, Imperial College London , London SW7 2AZ, United Kingdom.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Frost
authors.affiliation: Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin , Belfield, Dublin 4, Ireland.|Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Roche
authors.affiliation: Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin , Belfield, Dublin 4, Ireland.|Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Lorraine
authors.identifier: 0000-0002-7711-7499
authors.initials: L
authors.lastname: Brennan
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004032:Diet; D004041:Dietary Fats / Q000097:blood; D004435:Eating; D005260:Female; D006262:Health; D006801:Humans; D007494:Ireland; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D008055:Lipids
keywords: dietary biomarkers; dietary fat; diseases; lipidomics; metabolic syndrome