title: Topical Application of TAT-Superoxide Dismutase in Acupoints LI 20 on Allergic Rhinitis.
abstract: Reactive oxygen species are products of cellular metabolism and assigned important roles in biomedical science as deleterious factors in pathologies. In fact, some studies have shown that the therapeutic benefits of taking antioxidants were limited and the potential for therapeutic intervention remains unclear. New evidences showed that ROS have some ability of intercellular transportation. For treating allergic rhinitis, as a novel intracellular superoxide quencher, TAT-SOD applied to acupoints LI 20 instead of directly to nasal cavity can be used to test that. TTA group apply TAT-SOD cream prepared by adding purified TAT-SOD to the vehicle cream to acupoints LI 20, while placebo group used the vehicle cream instead. TTN group applied the same TAT-SOD cream directly to nasal cavity three times daily. Symptom scores were recorded at baseline and days 8 and 15. For the overall efficacy rate, TTA group was 81.0%, while placebo group was 5.9% and TTN was 0%. Malondialdehyde levels decreased observably in TTA group, and superoxide dismutase, catalase, and glutathione peroxidase levels remained basically unaffected. Enzymatic scavenging of the intracellular superoxide at acupoints LI 20 proved to be effective in treating allergic rhinitis, while no improvement was observed with the placebo group and TTN group.
authors.affiliation: SIBS, CAS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Zhejiang Gongshang University, Hangzhou 310018, China.
authors.forename: Jing-Ke
authors.identifier: 0000-0003-0934-5198
authors.initials: JK
authors.lastname: Guo
authors.affiliation: SIBS, CAS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Zhejiang Gongshang University, Hangzhou 310018, China.
authors.forename: Ming-Ming
authors.identifier: 0000-0002-4771-5316
authors.initials: MM
authors.lastname: Xu
authors.affiliation: Acupuncture College, Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China.
authors.forename: Mei-Feng
authors.initials: MF
authors.lastname: Zheng
authors.affiliation: College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.
authors.forename: Shu-Tao
authors.identifier: 0000-0003-4882-9662
authors.initials: ST
authors.lastname: Liu
authors.affiliation: SIBS, CAS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Zhejiang Gongshang University, Hangzhou 310018, China.
authors.forename: Jian-Wu
authors.initials: JW
authors.lastname: Zhou
authors.affiliation: SIBS, CAS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Zhejiang Gongshang University, Hangzhou 310018, China.
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Ke
authors.affiliation: Natural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.
authors.forename: Tian-Bao
authors.identifier: 0000-0001-8011-9260
authors.initials: TB
authors.lastname: Chen
authors.affiliation: SIBS, CAS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Zhejiang Gongshang University, Hangzhou 310018, China.
authors.forename: Ping-Fan
authors.identifier: 0000-0003-3184-7290
authors.initials: PF
authors.lastname: Rao