title: Recent Temporal Changes in Atherosclerotic Cardiovascular Diseases in Ontario: Clinical and Health Systems Impact.
abstract: It is unknown how the contemporary burden of atherosclerotic cardiovascular disease (ASCVD) compares with historical trends.
  
  
  
  As part of the Cardiovascular Health in Ambulatory Care Research Team "big data" initiative, we used information from multiple population-based databases to study 20-year temporal trends in hospitalizations and deaths from ASCVD. We calculated hospitalization rates for 6 ASCVD events (acute myocardial infarction, unstable angina, stroke, transient ischemic attack, peripheral arterial disease, and congestive heart failure) and death rates resulting from ischemic heart disease, cerebrovascular disease and circulatory and noncirculatory causes in adults aged 20-105 years in Ontario, Canada from 1994-2014 (to 2012 for deaths).
  
  
  
  The overall age-standardized composite rate of hospitalization for the 6 conditions or circulatory deaths declined 49.2% in men (from 1533.4 per 100,000 in 1994 to 778.3 per 100,000 in 2012) and 49.9% in women (from 1191.2 per 100,000 in 1994 to 596.2 per 100,000 in 2012). The annual rates of decline were least evident among those aged 20-49 years for both sexes. The overall self-reported prevalence of Ontarians living with heart disease or stroke, or both, declined nonsignificantly (P for trend = 0.19), from 7.7% to 7.1% for men, and significantly (P for trend = 0.01), from 7.3% to 5.8% for women, from 2001-2012.
  
  
  
  Striking declines in hospitalizations and deaths from ASCVD were observed in Ontario from 1994-2014. However, the limited progress observed in younger Canadians highlights the need for ongoing efforts aimed at preventing and treating ASCVDs and their associated risk factors.
authors.affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address: tu@ices.on.ca.
authors.forename: Jack V
authors.initials: JV
authors.lastname: Tu
authors.affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
authors.forename: Anam M
authors.initials: AM
authors.lastname: Khan
authors.affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Kelvin
authors.initials: K
authors.lastname: Ng
authors.affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
authors.forename: Anna
authors.initials: A
authors.lastname: Chu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000453:epidemiology* / Q000628:therapy; D003695:Delivery of Health Care; D005260:Female; D006305:Health Status Indicators; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D055815:Young Adult