title: Anthropometry in Long-Term Survivors of Acute Lymphoblastic Leukemia in Childhood and Adolescence.
abstract: OBJECTIVE
  Body mass index (BMI) is an inadequate measure of nutritional status in children and adolescents with cancer as it does not distinguish muscle from adipose tissue. However, arm anthropometry offers simple assessments of fat mass and lean body mass; especially valuable in low- and middle-income countries where the great majority of young people with cancer live and access to sophisticated expensive measures of body composition is markedly limited.
  
  
  METHODS
  The nutritional status of 75 long-term survivors of acute lymphoblastic leukemia was assessed by arm anthropometry, in addition to BMI, in a cross-sectional cohort study. Normal ranges for triceps skin fold thickness (TSFT, a surrogate for fat mass) and mid-upper arm circumference (MUAC, a surrogate for lean body mass) were between the 15th and 85th percentiles for age and sex. Overweight/obesity was classified as a TSFT >85th percentile and sarcopenia as an MUAC <15th percentile. Height normalized indices for TSFT and MUAC were also calculated.
  
  
  RESULTS
  Overweight/obesity was identified in 1/3 of subjects by a BMI >25 and by TSFT; and 20% of the subjects had a TSFT >95th percentile. Only two subjects were sarcopenic. None met the combined criteria for sarcopenic obesity. TSFT and MUAC/height indices did not add sensitivity to identification of sarcopenia or obesity.
  
  
  CONCLUSIONS
  TSFT is a useful measure of overweight/obesity in this population, but MUAC does not identify a notable proportion with sarcopenia. Further resolution may be provided by more sophisticated measures of body composition.
authors.affiliation: 1 Service of Hematology-Oncology, McMaster Children's Hospital , Hamilton, Ontario, Canada .
authors.forename: Laura
authors.initials: L
authors.lastname: Collins
authors.affiliation: 2 Department of Nuclear Medicine, Hamilton Health Sciences , Hamilton, Ontario, Canada .
authors.forename: Lesley
authors.initials: L
authors.lastname: Beaumont
authors.affiliation: 1 Service of Hematology-Oncology, McMaster Children's Hospital , Hamilton, Ontario, Canada .
authors.forename: Amy
authors.initials: A
authors.lastname: Cranston
authors.affiliation: 1 Service of Hematology-Oncology, McMaster Children's Hospital , Hamilton, Ontario, Canada .
authors.forename: Stefanie
authors.initials: S
authors.lastname: Savoie
authors.affiliation: 1 Service of Hematology-Oncology, McMaster Children's Hospital , Hamilton, Ontario, Canada .
authors.forename: Trishana
authors.initials: T
authors.lastname: Nayiager
authors.affiliation: 1 Service of Hematology-Oncology, McMaster Children's Hospital , Hamilton, Ontario, Canada .|3 Division of Hematology-Oncology, Department of Pediatrics, McMaster University , Hamilton, Ontario, Canada .
authors.forename: Ronald
authors.initials: R
authors.lastname: Barr
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001132:Arm / Q000033:anatomy & histology*; D001823:Body Composition; D015992:Body Mass Index; D000073116:Cancer Survivors; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003906:Developing Countries; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D055948:Sarcopenia / Q000453:epidemiology*; D012885:Skinfold Thickness; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: acute lymphoblastic leukemia; anthropometry; survivors