title: HDR Pathological Image Enhancement Based on Improved Bias Field Correction and Guided Image Filter.
abstract: Pathological image enhancement is a significant topic in the field of pathological image processing. This paper proposes a high dynamic range (HDR) pathological image enhancement method based on improved bias field correction and guided image filter (GIF). Firstly, a preprocessing including stain normalization and wavelet denoising is performed for Haematoxylin and Eosin (H and E) stained pathological image. Then, an improved bias field correction model is developed to enhance the influence of light for high-frequency part in image and correct the intensity inhomogeneity and detail discontinuity of image. Next, HDR pathological image is generated based on least square method using low dynamic range (LDR) image, H and E channel images. Finally, the fine enhanced image is acquired after the detail enhancement process. Experiments with 140 pathological images demonstrate the performance advantages of our proposed method as compared with related work.
authors.affiliation: Software College of Northeastern University, Shenyang, Liaoning 110819, China.
authors.forename: Qingjiao
authors.identifier: 0000-0001-9371-0201
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Software College of Northeastern University, Shenyang, Liaoning 110819, China.
authors.forename: Huiyan
authors.identifier: 0000-0002-1428-8776
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Software College of Northeastern University, Shenyang, Liaoning 110819, China.
authors.forename: Ganzheng
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Software College of Northeastern University, Shenyang, Liaoning 110819, China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Li
authors.affiliation: Software College of Northeastern University, Shenyang, Liaoning 110819, China.
authors.forename: Shang
authors.initials: S
authors.lastname: Gong
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Shenyang 110015, China.
authors.forename: Benqiang
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Shenyang 110015, China.
authors.forename: Libo
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001706:Biopsy / Q000379:methods*; D003124:Colorimetry / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity