title: A Novel Marker of Impaired Aortic Elasticity in Never Treated Hypertensive Patients: Monocyte/High-Density Lipoprotein Cholesterol Ratio.
abstract: BACKGROUND
  Monocyte to high density lipoprotein cholesterol ratio (MHR) is generally understood to be a candidate marker of inflammation and oxidative stress. Therefore, we aimed to assess the association between MHR and aortic elastic properties in hypertensive patients.
  
  
  METHODS
  A total of 114 newly-diagnosed untreated patients with hypertension and 71 healthy subjects were enrolled. Aortic stiffness index, aortic strain and aortic distensibility were measured by using echocardiography.
  
  
  RESULTS
  Patients with hypertension had a significantly higher MHR compared to the control group (p < 0.001). Also, aortic stiffness index (p < 0.001) was significantly higher and aortic distensibility (p < 0.001) was lower in the hypertensive group. There was a positive correlation of MHR with aortic stiffness index (r = 0.294, p < 0.001) and negative correlation with aortic distensibility (r = -0.281, p < 0.001). In addition, MHR and high sensitivity C-reactive protein have a positive correlation (r = 0.30, p < 0.001). Furthermore, MHR was found to be an independent predictor of aortic distensibility and aortic stiffness index.
  
  
  CONCLUSIONS
  In patients with newly-diagnosed untreated essential hypertension, higher MHR was significantly associated with impaired aortic elastic properties.
authors.affiliation: Department of Cardiology, Dışkapı Yıldırım Beyazıt Education and Research Hospital.
authors.forename: Kadriye Gayretli
authors.initials: KG
authors.lastname: Yayla
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital.
authors.forename: Uğur
authors.initials: U
authors.lastname: Canpolat
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital.
authors.forename: Çagri
authors.initials: Ç
authors.lastname: Yayla
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboğa
authors.affiliation: Department of Cardiology, Dışkapı Yıldırım Beyazıt Education and Research Hospital.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akyel
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akdi
authors.affiliation: Department of Cardiology, Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Çiçek
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital.
authors.forename: Firat
authors.initials: F
authors.lastname: Ozcan
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital.
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydoğdu
keywords: Aortic stiffness; Hypertension; Inflammation; Oxidative stress