title: Malaria transmission and the sensitivity of aggressive mosquitoes to insecticides in a poorly urbanized area of the Deido health district in Douala (Cameroon).
abstract: The design of an appropriate strategy for mosquito control in urban areas must take into account the local ecoclimate and its particularities. This study sought to determine the dynamics of malaria transmission and the level of insecticide susceptibility of aggressive mosquitoes in Ndogbong, a poorly urbanized district of Douala. Mosquitoes were captured on volunteers in 4 houses and outdoors for 2 consecutive nights a month, from April to September 2014, and identified by molecular and morphologic techniques. The infectivity of vectors was determined by a circumsporozoite protein (CSP) ELISA test. The susceptibility of vectors to DDT, deltamethrin, and permethrin was also assessed. Overall, 3794 mosquitoes belonging to 6 species were captured in 96 person-nights. The aggressive mosquito fauna comprised : Culex pipiens (57.83%), Cx. poicilipes (1.45%), Anopheles gambiae s.l. (39.01%), Aedes albopictus (1.51%), and An. paludis (0.10%). An. coluzzii accounted for 97% of members of the Gambiae complex captured and was the only species found to be infected with P. falciparum, with an average infection rate of 1.9% (95% CI : 0.82-4.41). The mean entomological inoculation rate was estimated at 0.3 ib/p/n. Susceptibility testing on female An. gambiae s.l. and Cx. pipiens revealed mortality rates lower than 85 % and thus suggested strong resistance to insecticides. An. Coluzzii develops well in poorly urbanized built-up areas of Africa and appears to be the major malaria vector in Ndogbong, especially during the rainy season. The high resistance to insecticides observed requires the development of new formulations for insecticides.
authors.affiliation: Laboratoire de biologie et physiologie animale, Faculté des sciences, Université de Douala, BP 2415, Douala, Cameroun.
authors.forename: P
authors.initials: P
authors.lastname: Akono Ntonga
authors.affiliation: Faculté des sciences, Université de Douala, Douala, Cameroun.
authors.forename: C
authors.initials: C
authors.lastname: Tonga
authors.affiliation: Faculté des sciences, Université de Douala, Douala, Cameroun.
authors.forename: J A
authors.initials: JA
authors.lastname: Mbida Mbida
authors.affiliation: Faculté de médecine et de sciences pharmaceutiques, Douala, Cameroun.
authors.forename: C
authors.initials: C
authors.lastname: Ndo
authors.affiliation: Institut de recherche de Yaoundé (IRY), Organisation pour la coordination de la lutte contre les endémies en Afrique centrale, Yaoundé, Cameroun.
authors.forename: P
authors.initials: P
authors.lastname: Awono Ambene
authors.affiliation: Faculté des sciences, Université de Douala, Douala, Cameroun.
authors.forename: L G
authors.initials: LG
authors.lastname: Lehman
authors.affiliation: Faculté des sciences, Université de Douala, Douala, Cameroun.
authors.forename: R
authors.initials: R
authors.lastname: Ngaha
authors.affiliation: Faculté des sciences, Université de Douala, Douala, Cameroun.
authors.forename: O E
authors.initials: OE
authors.lastname: Ngo Hondt
authors.affiliation: Faculté des sciences, Université de Douala, Douala, Cameroun.
authors.forename: M F
authors.initials: MF
authors.lastname: Peka Nsangou
authors.affiliation: Faculté des Sciences, Université de Yaoundé I, Yaoundé, Cameroun.
authors.forename: N
authors.initials: N
authors.lastname: Tedongmo Lopedji
mesh_terms: D000818:Animals; D002163:Cameroon; D009033:Culicidae; D006801:Humans; D007303:Insect Vectors; D007305:Insecticide Resistance; D008288:Malaria / Q000635:transmission*; D014504:Urban Health
keywords: An. Coluzzii; Cameroon; malaria; resistance; urbanization