title: MicroRNA 155 and viral-induced neuroinflammation.
abstract: MicroRNA (miRNA) regulation of gene expression is becoming an increasingly recognized mechanism by which host immune responses are governed following microbial infection. miRNAs are short, non-coding RNAs that repress translation of target genes, and have been implicated in a number of activities that modulate host immune responses, including the regulation of immune cell proliferation, survival, expansion, differentiation, migration, polarization, and effector function. This review highlights several examples in which mammalian-encoded miR-155 influences immune responses following viral infection of the CNS.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, United States. Electronic address: laura.dickey@path.utah.edu.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Dickey
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, United States. Electronic address: timothy.hanley@hsc.utah.edu.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Hanley
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, United States. Electronic address: thomas.huffaker@path.utah.edu.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Huffaker
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, United States. Electronic address: andrew.ramstead@path.utah.edu.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Ramstead
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, United States. Electronic address: ryan.oconnell@path.utah.edu.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: O'Connell
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, United States. Electronic address: tom.lane@path.utah.edu.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Lane
mesh_terms: D000818:Animals; D004660:Encephalitis / Q000209:etiology / Q000276:immunology / Q000821:virology; D015967:Gene Expression Regulation, Viral / Q000276:immunology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009187:Myelitis / Q000209:etiology / Q000276:immunology / Q000821:virology; D014777:Virus Diseases / Q000150:complications*
chemical_list: D035683:MicroRNAs
keywords: MicroRNAs; Neuroinflammation; Neuropathogenesis; Neurotropic viruses; miR-155