title: Hepatocellular carcinoma: an evolving challenge in viral hepatitis and HIV coinfection.
abstract: Liver-related morbidity and mortality is expanding in people living with HIV. Hepatocellular carcinoma (HCC), the third most lethal malignancy on a global scale, is a dominant complication of chronic liver disease and cirrhosis in patients with coexisting hepatitis. HIV infection further complicates the clinical heterogeneity of HCC, posing concurrent challenges stemming from the underlying immunological status of the patients and the ongoing need for combined antiretroviral therapy. In this article, we review the multiple clinical implications that characterize the multidisciplinary management of HCC in the context of HIV infection.
authors.affiliation: aDepartment of Surgery and Cancer, Hammersmith Campus of Imperial College London bDepartment of Oncology, National Centre for HIV Malignancies cDepartment of HIV Medicine, Chelsea & Westminster Hospital, London, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Pinato
authors.forename: Alessia
authors.initials: A
authors.lastname: Dalla Pria
authors.forename: Rohini
authors.initials: R
authors.lastname: Sharma
authors.forename: Mark
authors.initials: M
authors.lastname: Bower
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000821:virology; D060085:Coinfection / Q000150:complications*; D019468:Disease Management; D015658:HIV Infections / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000821:virology