title: Open Clinical Trial on Using Nifuroxazide Compared to Probiotics in Treating Acute Diarrhoeas in Adults.
abstract: BACKGROUND
  Nifuroxazide is well known and often used anti-diarrhoeal medicine which has been pushed back from routine practice in recent years and often replaced with probiotics. Even probiotics are accepted and placed in some therapeutic guidelines for diarrhoea treatment, there are no enough evidence for its effectiveness and no comparative efficacy data with nifuroxazide in treatment of acute diarrhea.
  
  
  METHODS
  In open, prospective observational study, the efficacy and safety of nifuroxazide were compared with a probiotic containing lactic acid bacteria in the treatment of acute diarrhoea. A total number of 169 adult patients were included in this study, who administered nifuroxazide in the dose of 200 mg/4 times a day, while they took preparation containing lactic acid bacteria (1,2 x 107live lyophilised lactic-acid bacteria) three times a day for three days.
  
  
  RESULTS
  Mean time to last unformed stool (TLUS) in a group which was treated with nifuroxazide was two days, while it took five days for the stool normalisation in the group using probiotic (p=0.0001).
  
  
  CONCLUSIONS
  Orally administered nifuroxazide has demonstrated better efficiency as compared to probiotic in treating acute diarrhoea, and both medicines have shown the same safety and tolerance in this study.
authors.affiliation: Clinical Pharmacology, Clinical Center University of Sarajevo.
authors.forename: Begler
authors.initials: B
authors.lastname: Begovic
authors.affiliation: Clinic for Infectious Diseases, University Clinical Center Tuzla.
authors.forename: Sead
authors.initials: S
authors.lastname: Ahmedtagic
authors.affiliation: Service for Contagious Diseases and Unclear Febrile Conditions, Cantonal Hospital in Zenica.
authors.forename: Lejla
authors.initials: L
authors.lastname: Calkic
authors.affiliation: Bosnalijek JSC, Sarajevo, Jukiceva 53, 71 000 Sarajevo, Bosnia and Herzegovina.
authors.forename: Midhat
authors.initials: M
authors.lastname: Vehabović
authors.affiliation: Bosnalijek JSC, Sarajevo, Jukiceva 53, 71 000 Sarajevo, Bosnia and Herzegovina.
authors.forename: Sanela Bakić
authors.initials: SB
authors.lastname: Kovacevic
authors.affiliation: Bosnalijek JSC, Sarajevo, Jukiceva 53, 71 000 Sarajevo, Bosnia and Herzegovina.
authors.forename: Tarik
authors.initials: T
authors.lastname: Catic
authors.affiliation: Bosnalijek JSC, Sarajevo, Jukiceva 53, 71 000 Sarajevo, Bosnia and Herzegovina.
authors.forename: Meliha
authors.initials: M
authors.lastname: Mehic
keywords: Acute diarrhea in adults; Nifuroxazide; Probiotics