title: Effects of social adversity and HIV on subcortical shape and neurocognitive function.
abstract: The purpose of the current study was to examine the independent and interactive effects of social adversity (SA) and HIV infection on subcortical shape alterations and cognitive functions. Participants included HIV+ (n = 70) and HIV- (n = 23) individuals who underwent MRI, neurocognitive and clinical assessment, in addition to completing questionnaires from which responses were used to create an SA score. Bilateral amygdalae and hippocampi were extracted from T1-weighted images. Parametric statistical analyses were used to compare the radial distance of the structure surface to a median curve to determine the presence of localized shape differences as a function of HIV, SA and their interaction. Next, multiple regression was used to examine the interactive association between HIV and SA with cognitive performance data. An HIV*SA interactive effect was found on the shape of the right amygdala and left hippocampus. Specifically, HIV-infected participants (but not HIV-uninfected controls) who evidenced higher levels of SA displayed an inward deformation of the surface consistent with reduced volume of these structures. We found interactive effects of HIV and SA on learning/memory performance. These results suggest that HIV+ individuals may be more vulnerable to neurological and cognitive changes in the hippocampus and amygdala as a function of SA than HIV- individuals, and that SA indicators of childhood SES and perceived racial discrimination are important components of adversity that are associated with cognitive performance.
authors.affiliation: David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, 28-263, Los Angeles, CA, 90095, USA. athames@mednet.ucla.edu.
authors.forename: April D
authors.initials: AD
authors.lastname: Thames
authors.affiliation: David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, 28-263, Los Angeles, CA, 90095, USA.|Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA.
authors.forename: Taylor P
authors.initials: TP
authors.lastname: Kuhn
authors.affiliation: David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, 28-263, Los Angeles, CA, 90095, USA.|Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Zanjbeel
authors.initials: Z
authors.lastname: Mahmood
authors.affiliation: David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, 28-263, Los Angeles, CA, 90095, USA.|Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Bilder
authors.affiliation: Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Williamson
authors.affiliation: David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, 28-263, Los Angeles, CA, 90095, USA.
authors.forename: Elyse J
authors.initials: EJ
authors.lastname: Singer
authors.affiliation: California State University Northridge, Northridge, CA, USA.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Arentoft
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D003071:Cognition; D004198:Disease Susceptibility; D005260:Female; D007839:Functional Laterality; D015658:HIV Infections / Q000000981:diagnostic imaging* / Q000523:psychology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011287:Prejudice; D012044:Regression Analysis; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Adversity; Amygdala; Cognition; Hippocampus; Human immunodeficiency virus; Structural neuroimaging