title: Frontal beta-theta network during REM sleep.
abstract: We lack detailed knowledge about the spatio-temporal physiological signatures of REM sleep, especially in humans. By analyzing intracranial electrode data from humans, we demonstrate for the first time that there are prominent beta (15-35 Hz) and theta (4-8 Hz) oscillations in both the anterior cingulate cortex (ACC) and the DLPFC during REM sleep. We further show that these theta and beta activities in the ACC and the DLPFC, two relatively distant but reciprocally connected regions, are coherent. These findings suggest that, counter to current prevailing thought, the DLPFC is active during REM sleep and likely interacting with other areas. Since the DLPFC and the ACC are implicated in memory and emotional regulation, and the ACC has motor areas and is thought to be important for error detection, the dialogue between these two areas could play a role in the regulation of emotions and in procedural motor and emotional memory consolidation.
authors.affiliation: Department of Mathematics and Statistics, Boston University, Boston, United States.|Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, United States.
authors.forename: Sujith
authors.identifier: 0000-0001-6385-3922
authors.initials: S
authors.lastname: Vijayan
authors.affiliation: Department of Mathematics and Statistics, Boston University, Boston, United States.
authors.forename: Kyle Q
authors.initials: KQ
authors.lastname: Lepage
authors.affiliation: Department of Mathematics and Statistics, Boston University, Boston, United States.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Kopell
authors.affiliation: Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, United States.
authors.forename: Sydney S
authors.initials: SS
authors.lastname: Cash
mesh_terms: D000328:Adult; D001611:Beta Rhythm; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D017397:Prefrontal Cortex / Q000502:physiology*; D012895:Sleep, REM; D013826:Theta Rhythm
keywords: Anterior Cingulate Cortex; Dorsolateral Prefrontal Cortex; Oscillations; REM Sleep; human; neuroscience