title: Effect ofDendrobium officinaleExtraction on Gastric Carcinogenesis in Rats.
abstract: Dendrobium officinale(Tie Pi Shi Hu in Chinese) has been widely used to treat different diseases in China. Anticancer effect is one of the important effects ofDendrobium officinale. However, the molecular mechanism of its anticancer effect remains unclear. In the present study, gastric carcinogenesis in rats was used to evaluate the effect ofDendrobium officinaleon cancer, and its pharmacological mechanism was explored.Dendrobium officinaleextracts (4.8 and 2.4 g/kg) were orally administered to the rats of the gastric carcinogenesis model. Compared with the cancer model group, the high dose ofDendrobium officinaleextracts significantly inhibited the rate of carcinogenesis. Further analysis revealed thatDendrobium officinaleextracts could regulate the DNA damage, oxidative stress, and cytokines related with carcinogenesis and induce cell apoptosis in order to prevent gastric cancer.
authors.affiliation: Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
authors.forename: Yi
authors.identifier: 0000-0001-9692-0562
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
authors.forename: Xi-Ming
authors.initials: XM
authors.lastname: Lan
authors.affiliation: Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Xu
authors.affiliation: School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: You-Zhi
authors.initials: YZ
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.affiliation: Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
authors.forename: Hong-Ning
authors.identifier: 0000-0002-8246-4073
authors.initials: HN
authors.lastname: Liu