title: A Prospective Study of Platelet-Rich Plasma as Biological Augmentation for Acute Achilles Tendon Rupture Repair.
abstract: Acute Achilles tendon rupture is one of the most common tendon injuries in adults. We hypothesized that Platelet-Rich Plasma (PRP) can be used as biological augmentation for surgical treatment of acute Achilles tendon rupture. Our study is a prospective randomized controlled trial. Patients with acute Achilles tendon rupture undergoing surgical repair were randomly assigned into either control group or PRP group. End-to-end modified Krackow suture was performed in both groups. In the PRP group, PRP was injected into the paratenon sheath and around the ruptured tissue after the tendon was repaired. Postoperatively we evaluated isokinetic muscle strength at 3, 6, 12, and 24 months. In addition, ankle ROM, calf circumference, Leppilahti score, and the SF-36 score were evaluated at 6, 12, and 24 months after operation. At 3 months, the PRP group had better isokinetic muscle. The PRP group also achieved higher SF-36 and Leppilahti scores at 6 and 12 months. At 24 months, the PRP group had an improved ankle range of motion compared to the control group. Our study results suggest that PRP can serve as a biological augmentation to acute Achilles tendon rupture repair and improves both short and midterm functional outcomes.
authors.affiliation: Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zou
authors.affiliation: The People's Hospital of Shigatse City, Shigatse, Tibet 857000, China.
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Mo
authors.affiliation: Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Zhongmin
authors.identifier: 0000-0002-2467-8735
authors.initials: Z
authors.lastname: Shi
authors.affiliation: The People's Hospital of Shigatse City, Shigatse, Tibet 857000, China.
authors.forename: Tanzhu
authors.initials: T
authors.lastname: Li
authors.affiliation: Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xue
authors.affiliation: Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Mei
authors.affiliation: Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Li
mesh_terms: D000125:Achilles Tendon / Q000293:injuries* / Q000503:physiopathology; D000328:Adult; D016512:Ankle Injuries / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D017713:Platelet Transfusion / Q000379:methods*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D012421:Rupture / Q000175:diagnosis* / Q000628:therapy*; D013708:Tendon Injuries / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome