title: Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke.
abstract: Hemorrhagic transformation occurs in about 10-15% of patients with acute ischemic stroke. The treatment of hemorrhagic conversion is complex and includes blood pressure management, reversing coagulopathy, and managing its complications including increased intracranial pressure. Future research should be directed on identifying indications to treat and use of appropriate homeostatic regimens to effectively reverse the different anticoagulants and thrombolytic agents in an attempt to improve outcomes of patients with hemorrhagic transformation.
authors.affiliation: Department of Neurology, The Warren Alpert Medical School of Brown University, 353 Eddy Street APC 530, Providence, RI, 02903, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Stone
authors.affiliation: Departments of Neurology, Columbia University Medical Center, New York, NY, USA.
authors.forename: Joshua Z
authors.initials: JZ
authors.lastname: Willey
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MI, USA.
authors.forename: Salah
authors.initials: S
authors.lastname: Keyrouz
authors.affiliation: Department of Internal Medicine, Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: James
authors.initials: J
authors.lastname: Butera
authors.affiliation: Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: McTaggart
authors.affiliation: Department of Neurology, The Warren Alpert Medical School of Brown University, 353 Eddy Street APC 530, Providence, RI, 02903, USA.
authors.forename: Shawna
authors.initials: S
authors.lastname: Cutting
authors.affiliation: Department of Neurology, The Warren Alpert Medical School of Brown University, 353 Eddy Street APC 530, Providence, RI, 02903, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Silver
authors.affiliation: Department of Neurology, The Warren Alpert Medical School of Brown University, 353 Eddy Street APC 530, Providence, RI, 02903, USA.|Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Bradford
authors.initials: B
authors.lastname: Thompson
authors.affiliation: Department of Neurology, The Warren Alpert Medical School of Brown University, 353 Eddy Street APC 530, Providence, RI, 02903, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Furie
authors.affiliation: Department of Neurology, The Warren Alpert Medical School of Brown University, 353 Eddy Street APC 530, Providence, RI, 02903, USA. shadiyaghi@yahoo.com.
authors.forename: Shadi
authors.initials: S
authors.lastname: Yaghi
keywords: Anticoagulation; Hemorrhagic transformation; Ischemic stroke; Thrombolytic therapy; Treatment