title: Macular hole in Stargardt disease: Clinical and ultra-structural observation.
abstract: To report for the first time a case report of a Stargardt disease patient who developed a macular hole (MH) which was treated with a surgical approach.
  
  
  
  Case report.
  
  
  
  After vitrectomy a complete closure of the MH was obtained and the best-corrected visual acuity remained stable. No complications were reported after one year of follow-up. An ultra-structural examination of the removed internal limiting membrane (ILM) and epiretinal membrane (ERM) was carried out under electron microscopy.
  
  
  
  Vitreo-retinal surgery could represent a therapeutic option to treat vitreo-retinal interface abnormalities associated with inherited retinal diseases.
authors.affiliation: a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
authors.forename: Stanislao
authors.initials: S
authors.lastname: Rizzo
authors.affiliation: a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
authors.forename: Dario Pasquale
authors.initials: DP
authors.lastname: Mucciolo
authors.affiliation: a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Bacherini
authors.affiliation: a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
authors.forename: Vittoria
authors.initials: V
authors.lastname: Murro
authors.affiliation: a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Vannozzi
authors.affiliation: a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Virgili
authors.affiliation: b Department of Experimental & Clinical Medicine , Research Unit of Histology & Embryology, University of Florence , Florence , Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Bani
authors.affiliation: a Department of Translational Surgery and Medicine , Eye Clinic, University of Florence , Florence , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sodi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000328:Adult; D001485:Basement Membrane / Q000601:surgery / Q000648:ultrastructure*; D004596:Electroretinography; D019773:Epiretinal Membrane / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D012167:Retinal Perforations / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D000080362:Stargardt Disease; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014821:Vitrectomy; D057586:Vitreoretinal Surgery
chemical_list: C056475:ABCA4 protein, human; D018528:ATP-Binding Cassette Transporters
keywords: Genetics; Stargardt disease; macular hole; retinal dystrophy; vitrectomy