title: Role of Non-coding Regulatory RNA in the Virulence of Human PathogenicVibrios.
abstract: In recent decades, the identification of small non-coding RNAs in bacteria has revealed an important regulatory mechanism of gene expression involved in the response to environmental signals and to the control of virulence. In the familyVibrionaceae, which includes several human and animal pathogens, small non-coding RNAs (sRNAs) are closely related to important processes including metabolism, quorum sensing, virulence, and fitness. Studies conductedin silicoand experiments using microarrays and high-throughput RNA sequencing have led to the discovery of an unexpected number of sRNAs inVibrios. The present review discusses the most relevant reports regarding the mechanisms of action of sRNAs and their implications in the virulence of the main human pathogens in the familyVibrionaceae: Vibrio parahaemolyticus, V. vulnificusandV. cholerae.
authors.affiliation: Centro de Investigación Biomédica, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile San Miguel, Chile.
authors.forename: Diliana
authors.initials: D
authors.lastname: Pérez-Reytor
authors.affiliation: Centro de Investigación Biomédica, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de ChileSan Miguel, Chile; Institute of Nutrition and Food Technology, University of ChileSantiago, Chile.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Plaza
authors.affiliation: Institute of Nutrition and Food Technology, University of Chile Santiago, Chile.
authors.forename: Romilio T
authors.initials: RT
authors.lastname: Espejo
authors.affiliation: Institute of Nutrition and Food Technology, University of Chile Santiago, Chile.
authors.forename: Paola
authors.initials: P
authors.lastname: Navarrete
authors.affiliation: Laboratory of Microbiology, Institute of Biology, Pontificia Universidad Católica de Valparaíso Valparaíso, Chile.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bastías
authors.affiliation: Centro de Investigación Biomédica, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile San Miguel, Chile.
authors.forename: Katherine
authors.initials: K
authors.lastname: Garcia
keywords: Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; bioinformatics analysis; pathogenic vibrios; quorum sensing; sRNA; virulence