title: The Hippo pathway in tissue homeostasis and regeneration.
abstract: While several organs in mammals retain partial regenerative capability following tissue damage, the underlying mechanisms remain unclear. Recently, the Hippo signaling pathway, better known for its function in organ size control, has been shown to play a pivotal role in regulating tissue homeostasis and regeneration. Upon tissue injury, the activity of YAP, the major effector of the Hippo pathway, is transiently induced, which in turn promotes expansion of tissue-resident progenitors and facilitates tissue regeneration. In this review, with a general focus on the Hippo pathway, we will discuss its major components, functions in stem cell biology, involvement in tissue regeneration in different organs, and potential strategies for developing Hippo pathway-targeted regenerative medicines.
authors.affiliation: Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
authors.forename: Aijuan
authors.initials: A
authors.lastname: Yu
authors.affiliation: Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. fxyu@fudan.edu.cn.|Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China. fxyu@fudan.edu.cn.|Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, 200032, China. fxyu@fudan.edu.cn.
authors.forename: Fa-Xing
authors.initials: FX
authors.lastname: Yu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D000090683:Hippo Signaling Pathway; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012038:Regeneration / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Hippo; YAP; regeneration