title: Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels.
abstract: Calcium-activated chloride channels (CaCCs) are a family of anionic transmembrane ion channels. They are mainly responsible for the movement of Cl-and other anions across the biological membranes, and they are widely expressed in different tissues. Since the Cl-flow into or out of the cell plays a crucial role in hyperpolarizing or depolarizing the cells, respectively, the impact of intracellular Ca2+concentration on these channels is attracting a lot of attentions. After summarizing the molecular, biophysical, and pharmacological properties of CaCCs, the role of CaCCs in normal cellular functions will be discussed, and I will emphasize how dysregulation of CaCCs in pathological conditions can account for different diseases. A better understanding of CaCCs and a pivotal regulatory role of Ca2+can shed more light on the therapeutic strategies for different neurological disorders that arise from chloride dysregulation, such as asthma, cystic fibrosis, and neuropathic pain.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.|Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Mohammad Amin
authors.identifier: http://orcid.org/0000-0002-1856-503X
authors.initials: MA
authors.lastname: Kamaleddin
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D018118:Chloride Channels / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D008564:Membrane Potentials; D049990:Membrane Transport Modulators / Q000494:pharmacology*; D009437:Neuralgia / Q000188:drug therapy / Q000378:metabolism; D011487:Protein Conformation; D015398:Signal Transduction / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D018118:Chloride Channels; D002712:Chlorides; D049990:Membrane Transport Modulators; D002118:Calcium
keywords: anoctamin; calcium-activated chloride channel; chloride dynamic; chloride regulation; cystic fibrosis