title: Nuclear-Targeted Multifunctional Magnetic Nanoparticles for Photothermal Therapy.
abstract: The pursuit of multifunctional, innovative, more efficient, and safer cancer treatment has gained increasing interest in the research of preclinical nanoparticle-mediated photothermal therapy (PTT). Cell nucleus is recognized as the ideal target for cancer treatment because it plays a central role in genetic information and the transcription machinery reside. In this work, an efficient nuclear-targeted PTT strategy is proposed using transferrin and TAT peptide (TAT: YGRKKRRQRRR) conjugated monodisperse magnetic nanoparticles, which can be readily functionalized and stabilized for potential diagnostic and therapeutic applications. The monodisperse magnetic nanoparticles exhibit high photothermal conversion efficiency (≈37%) and considerable photothermal stability. They also show a high magnetization value and transverse relaxivity (207.1 mm-1s-1), which could be applied for magnetic resonance imaging. The monodisperse magnetic nanoparticles conjugated with TAT peptides can efficiently target the nucleus and achieve the imaging-guided function, efficient cancer cells killing ability. Therefore, this work may present a practicable strategy to develop subcellular organelle targeted PTT agents for simultaneous cancer targeting, imaging, and therapy.
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
authors.forename: Haibao
authors.initials: H
authors.lastname: Peng
authors.affiliation: Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
authors.forename: Guannan
authors.initials: G
authors.lastname: Guo
authors.affiliation: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, China.
authors.forename: Angang
authors.initials: A
authors.lastname: Dong
authors.affiliation: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
authors.forename: Wuli
authors.initials: W
authors.lastname: Yang
mesh_terms: D000072283:A549 Cells; D000818:Animals; D002467:Cell Nucleus; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006979:Hyperthermia, Induced; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy
chemical_list: D058185:Magnetite Nanoparticles
keywords: TAT; magnetic nanoparticle; nuclear-targeted; photothermal therapy; transferrin