title: The application of skin metabolomics in the context of transdermal drug delivery.
abstract: Metabolomics is a powerful emerging tool for the identification of biomarkers and the exploration of metabolic pathways in a high-throughput manner. As an administration site for percutaneous absorption, the skin has a variety of metabolic enzymes, except other than hepar. However, technologies to fully detect dermal metabolites remain lacking. Skin metabolomics studies have mainly focused on the regulation of dermal metabolites by drugs or on the metabolism of drugs themselves. Skin metabolomics techniques include collection and preparation of skin samples, data collection, data processing and analysis. Furthermore, studying dermal metabolic effects via metabolomics can provide novel explanations for the pathogenesis of some dermatoses and unique insights for designing targeted prodrugs, promoting drug absorption and controlling drug concentration. This paper reviews current progress in the field of skin metabolomics, with a specific focus on dermal drug delivery systems and dermatosis.
authors.affiliation: School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China. Electronic address: gdlijinling2009@126.com.
authors.forename: Jinling
authors.initials: J
authors.lastname: Li
authors.affiliation: Research Department of Pharmacognosy, China Pharmaceutical University, Nanjing, Jiangsu, China. Electronic address: xuweitong22@126.com.
authors.forename: Weitong
authors.initials: W
authors.lastname: Xu
authors.affiliation: School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China. Electronic address: yibiaoleung@126.com.
authors.forename: Yibiao
authors.initials: Y
authors.lastname: Liang
authors.affiliation: School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China. Electronic address: gdwanghui2006@126.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D055432:Metabolomics / Q000379:methods; D011355:Prodrugs / Q000008:administration & dosage* / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption / Q000502:physiology
chemical_list: D015415:Biomarkers; D011355:Prodrugs
keywords: Biomarker; Metabolomics; Skin; Techniques; Transdermal drug delivery