title: [Clinical Evaluation of Hyperthermic Intraperitoneal Chemotherapy(HIPEC)in Colorectal Cancer Patients at High Risk of Peritoneal Recurrence].
abstract: OBJECTIVE
  We herein report the clinical outcomes of hyperthermic intraperitoneal chemotherapy(HIPEC)in patients at high risk of colorectal peritoneal metastasis.
  
  
  METHODS
  We enrolled 21 patients with advanced colorectal cancer who were received HIPEC between 2009 and 2014. Retrospectively, we evaluated the short-term and long-term outcomes of these cases.
  
  
  RESULTS
  We performed HIPEC for 12 patients with primary cancer and 9 with recurrent cancer. Perioperative complications characteristic of HIPEC did not occur. Seventeen patients(81%)had postoperative recurrence, 5 of whom had a peritoneal recurrence, and all of them already had synchronous peritoneal metastasis at the time of HIPEC. Patients with a higher peritoneal cancer index(PCI)had a tendency towards a higher rate of peritoneal recurrence than those with a lower PCI(11[median]vs 4; p=0.08).
authors.affiliation: Dept. of Gastroenterological Surgery, Shiga University of Medical Science.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohta
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Sonoda
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ueki
authors.forename: Toru
authors.initials: T
authors.lastname: Miyake
authors.forename: Eiji
authors.initials: E
authors.lastname: Mekata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Endo
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kaida
authors.forename: Katsushi
authors.initials: K
authors.lastname: Takebayashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Murata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Hiroya
authors.initials: H
authors.lastname: Akabori
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Naka
authors.forename: Masaji
authors.initials: M
authors.lastname: Tani
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000517:prevention & control* / Q000556:secondary; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome