title: Analysis of Numerous Androgen Disruptors in Fish by Gas Chromatography Tandem Mass Spectrometry.
abstract: An improved analytical method was developed for the simultaneous quantification of numerous androgen disruptors-vinclozolin, dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes, chlordane, heptachlor, dieldrin, endrin, and aldrin-in fish, followed by GC with tandem MS (MS/MS). Extraction, cleanup, and MS/MS parameters of analytes were optimized. The LOQs of the analytes ranged from 0.3 to 3.7 μg/kg. Reasonable recoveries (73.7-119.2%) were demonstrated at different spike levels with RSDs lower than 12.2%. This method was applied for the analysis of the target analytes in fish samples sold in Hangzhou, China, and DDTs were found to be the predominant contaminants in fish samples.
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Laboratory of Chemistry and Physics, Hangzhou 310021, People's Republic of China.
authors.forename: Shaoying
authors.initials: S
authors.lastname: Liu
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Laboratory of Chemistry and Physics, Hangzhou 310021, People's Republic of China.
authors.forename: Tianbin
authors.initials: T
authors.lastname: Bian
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Laboratory of Chemistry and Physics, Hangzhou 310021, People's Republic of China.
authors.forename: Huali
authors.initials: H
authors.lastname: He
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Laboratory of Chemistry and Physics, Hangzhou 310021, People's Republic of China.
authors.forename: Huang
authors.initials: H
authors.lastname: Huang
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Laboratory of Chemistry and Physics, Hangzhou 310021, People's Republic of China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Jin
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Laboratory of Chemistry and Physics, Hangzhou 310021, People's Republic of China.
authors.forename: Shuting
authors.initials: S
authors.lastname: Wang
authors.affiliation: Zhejiang University, Institute of Pesticide and Environmental Toxicology, Hangzhou 310029, People's Republic of China.
authors.forename: Guonian
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000728:Androgens; D000818:Animals; D002681:China; D052244:Endocrine Disruptors / Q000032:analysis*; D005399:Fishes; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D017747:Seafood / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D000728:Androgens; D052244:Endocrine Disruptors