title: Can killers be saviors?
abstract: Autoimmunity and cancer have a multifarious epidemiology. Often, it is because of an impaired genome, culminating in functional aberrations in the human system. Systemic lupus erythematosus (SLE) is a heterogeneous complex disease which ensues due to the failure of the immune system to distinguish between self and non-self antigens, thus producing autoantibodies against DNA, RNA and proteins. Cancer, the other side of the same coin, results from an excessive proliferation of cells that evade immune regulation as a result of incompetent defense by T-cells, B-cells and macrophages. Recent findings have indicated that lupus autoantibodies could be used as an effective weapon to kill cancerous cells. This is an attempt to take an account of malicious 'lupus autoantibodies' and their role in neutralizing cancerous cells which may help in enhancing the survival rate of cancer patients, hence, killers can be saviors.
authors.affiliation: 1 Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Greater Noida, Uttar Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Singh
authors.affiliation: 2 Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Agarwal
authors.affiliation: 2 Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: J
authors.initials: J
authors.lastname: Prosek
authors.affiliation: 1 Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Greater Noida, Uttar Pradesh, India.
authors.forename: M S K
authors.initials: MSK
authors.lastname: Jayadev
authors.affiliation: 1 Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Greater Noida, Uttar Pradesh, India.
authors.forename: A
authors.initials: A
authors.lastname: Singh
mesh_terms: D001323:Autoantibodies / Q000276:immunology / Q000627:therapeutic use*; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies
keywords: Systemic lupus erythematosus (SLE); autoantibodies; cancer; lupus; protective autoimmunity