title: The evaluation of central corneal thickness and intraocular pressure in conjunction with tear IGF-1 levels in patients with acromegaly.
abstract: OBJECTIVE
  To compare the central corneal thickness (CCT), intraocular pressure (IOP), and tear insulin-like growth factor 1 (IGF-1) levels between patients with acromegaly and a control group and to evaluate the possible effect of tear IGF-1 and duration of the disease on CCT and IOP.
  
  
  METHODS
  We included 31 patients with acromegaly (study group) and 40 age- and sex-matched controls in the study. Patients with acromegaly were divided into 2 subgroups based on disease status (active/inactive). All participants underwent complete ophthalmologic evaluation including CCT and IOP values. Basal tear samples were collected from both groups and tear IGF-1 levels were measured. The CCT, IOP, and tear IGF-1 levels were compared between groups and subgroups and the association between tear IGF-I levels and ocular parameters (CCT, IOP) and disease duration were also evaluated.
  
  
  RESULTS
  Central corneal thickness, IOP, and tear IGF-1 levels did not show a significant difference between study and control groups. We also did not find a significant difference in terms of CCT, IOP, or tear IGF-1 levels between subgroups of patients. Correlation analysis did not show an association between the duration of disease and tear IGF-1 levels with CCT or IOP.
  
  
  CONCLUSIONS
  There was no significant difference in tear IGF-1 levels between patients with acromegaly and controls. Additionally, there was no correlation between disease duration and tear IGF-1 levels with CCT or IOP levels. This lack of association may suggest that tear IGF-1 levels might not have an effect on CCT or IOP findings in patients with acromegaly.
authors.affiliation: Department of Ophthalmology, Samsun Training and Research Hospital, Samsun - Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Kan
authors.affiliation: Department of Endocrinology and Metabolism, Samsun Training and Research Hospital, Samsun - Turkey.
authors.forename: Elif K
authors.initials: EK
authors.lastname: Kan
authors.affiliation: Department of Biochemistry, School of Medicine, Ondokuz Mayıs University, Samsun - Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Okuyucu
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000378:metabolism; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D003315:Cornea / Q000473:pathology*; D003430:Cross-Sectional Studies; D005128:Eye Diseases / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000737:chemistry*; D014065:Tonometry, Ocular
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I