title: Usefulness of bronchoalveolar lavage and flow cytometry in patients with hematological malignancies and respiratory failure.
abstract: OBJECTIVE
  Strategies to improve the efficiency of bronchoalveolar lavage (BAL) are needed. We conducted a study to establish the diagnostic value of BAL in patients with hematological malignancies and pulmonary infiltrates.
  
  
  METHODS
  The correlation of cytologic and flow cytometric study of BAL with the microbiological findings and the clinical evolution was determined.
  
  
  RESULTS
  Seventy BAL were performed and flow cytometric study was analyzed in 23 of them. Fifty-three patients did not present any adverse event attributable to BAL. Anti-infectious therapy was modified in 64 (91%) patients. T lymphocyte count >0.3×109/l in peripheral blood was associated with longer OS at 3 years (53 vs. 22%, p=.009). Higher CD4 (>20/μL) and CD8 (>35/μL) lymphocyte counts in the BAL were associated with a longer OS at 3 years: 82 vs. 21% (p=.030) and 80 vs. 23% (p=.059).
  
  
  CONCLUSIONS
  Our study confirms the clinical value of BAL for treatment decision making in patients with hematological malignancies and acute respiratory failure.
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona, España; Instituto de Investigación contra la Leucemia Josep Carreras, Badalona, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: Christelle
authors.initials: C
authors.lastname: Ferrà
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona, España; Instituto de Investigación contra la Leucemia Josep Carreras, Badalona, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: bxicoy@iconcologia.net.
authors.forename: Blanca
authors.initials: B
authors.lastname: Xicoy
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona, España.
authors.forename: Nerea
authors.initials: N
authors.lastname: Castillo
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona, España.
authors.forename: Mireia
authors.initials: M
authors.lastname: Morgades
authors.affiliation: Instituto de Investigación contra la Leucemia Josep Carreras, Badalona, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: Jordi
authors.initials: J
authors.lastname: Juncà
authors.affiliation: Servicio de Neumología, Hospital Germans Trias i Pujol, Badalona, España.
authors.forename: Felipe
authors.initials: F
authors.lastname: Andreo
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona, España; Instituto de Investigación contra la Leucemia Josep Carreras, Badalona, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Millá
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona, España; Instituto de Investigación contra la Leucemia Josep Carreras, Badalona, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: Evarist
authors.initials: E
authors.lastname: Feliu
authors.affiliation: Servicio de Hematología, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona, España; Instituto de Investigación contra la Leucemia Josep Carreras, Badalona, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: Josep-María
authors.initials: JM
authors.lastname: Ribera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018893:Bronchoalveolar Lavage; D000066491:Clinical Decision-Making; D005260:Female; D005434:Flow Cytometry; D019337:Hematologic Neoplasms / Q000150:complications / Q000473:pathology*; D006801:Humans; D017254:Leukemic Infiltration; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult
keywords: Bronchoalveolar lavage; Citometría de flujo; Flow cytometry; Haematological malignancies; Hemopatías malignas; Insuficiencia respiratoria; Lavado broncoalveolar; Respiratory failure