title: Plasma L-carnitine levels of obese and non-obese polycystic ovary syndrome patients.
abstract: It is well-known that plasma L-carnitine concentrations are significantly decreased in obese individuals. A study showed that L-carnitine concentrations are significantly lower in lean PCOS patients than in lean healthy women. Thus, it has been suggested that lowered L-carnitine is associated with PCOS. This study also showed that the women with PCOS had significantly lower L-carnitine levels than those of the healthy controls. In addition, this study hypothesised that low L-carnitine levels in PCOS patients were associated with obesity and/or insulin resistance. Moreover, plasma L-carnitine concentrations were found to be statistically similar in PCOS patients and healthy controls, when controlled for obesity. This study implied that L-carnitine could be used as an adjunctive therapy in the management of insulin resistance or obesity in women who have PCOS. Further research might be planned to clarify the clinical effects of L-carnitine administration in PCOS patients with insulin resistance and/or obesity.
authors.affiliation: a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Celik
authors.affiliation: a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Kose
authors.affiliation: a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmazer
authors.affiliation: a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Gülengül N
authors.initials: GN
authors.lastname: Köken
authors.affiliation: a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Dagistan Tolga
authors.initials: DT
authors.lastname: Arioz
authors.affiliation: a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Kanat Pektas
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002331:Carnitine / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000097:blood* / Q000145:classification; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: D002331:Carnitine
keywords: L-Carnitine; obesity; polycystic ovary syndrome