title: RNA modifications and structures cooperate to guide RNA-protein interactions.
abstract: An emerging body of evidence indicates that post-transcriptional gene regulation relies not only on the sequence of mRNAs but also on their folding into intricate secondary structures and on the chemical modifications of the RNA bases. These features, which are highly dynamic and interdependent, exert direct control over the transcriptome and thereby influence many aspects of cell function. Here, we consider how the coupling of RNA modifications and structures shapes RNA-protein interactions at different steps of the gene expression process.
authors.affiliation: Department of Biochemistry, University of Illinois.
authors.forename: Cole J T
authors.initials: CJ
authors.lastname: Lewis
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Pan
authors.affiliation: Department of Biochemistry, University of Illinois.|Institute of Genomic Biology, University of Illinois, Urbana-Champaign, Illinois 61801, USA.
authors.forename: Auinash
authors.initials: A
authors.lastname: Kalsotra
mesh_terms: D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D019154:Protein Splicing; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism; D000094704:RNA, Guide, CRISPR-Cas Systems
chemical_list: D011506:Proteins; D012333:RNA, Messenger; D000094704:RNA, Guide, CRISPR-Cas Systems