title: [Coffee as hepatoprotective factor].
abstract: The mind about the coffee did change upon the recent studies and metaanalysis of the last years. Consensual protective effect of coffee on the progression of chronic liver diseases (NASH, viral hepatitis, liver cirrhosis, hepatocelullar carcinoma) was detected in experimental, clinical and large population studies together with decrease of mortality. Antioxidant, antifibrotic, insulinsensitizing and anticarcinogenic effect of coffee were detected. Modulation of genetic expression of key enzymes of fatty acid synthesis, modulation of mRNA included in autophagia, reduction of stress of endoplasmatic reticulum together with decrease of proinflammatory cytokines and decrease of fibrogenesis are main mechanisms. Chlorogenic acids, diterpens (cafestol, kahweol), caffein, polyfenols and melanoidins are key protective components of coffee. Inverse dose-dependent correlation of coffee consumption with liver diseases was found in clinical and population studies. Coffee is non-pharmacological tool of primary and secondary prevention of chronic liver diseases. Review of published data together with supposed mechanisms of hepatoprotection are given.Key words: coffee - hepatoprotective effect - metaanalysis.
authors.forename: Mária
authors.initials: M
authors.lastname: Szántová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Ďurkovičová
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control; D002908:Chronic Disease; D003069:Coffee; D004224:Diterpenes; D006801:Humans; D008103:Liver Cirrhosis / Q000517:prevention & control; D008107:Liver Diseases / Q000188:drug therapy / Q000517:prevention & control*; D008113:Liver Neoplasms / Q000517:prevention & control; D065626:Non-alcoholic Fatty Liver Disease / Q000517:prevention & control
chemical_list: D000975:Antioxidants; D003069:Coffee; D004224:Diterpenes; C053401:kahweol; C053400:cafestol