title: UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
abstract: Systemic lupus erythematosus (SLE) is a multisystem disease affecting many organs, and the most severe complication is lupus nephritis. Podocyte injury and loss play vital roles in the pathogenesis of lupus nephritis. Studies have shown that ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is involved in the pathogenesis and progression of many diseases, such as neurodegenerative disorders, cancers, and diabetes. Recently, numerous studies have indicated that UCH-L1 was upregulated in the podocytes in immune complex-mediated glomerulonephritis. This increase was correlated with disease aggravation. In this review, we discuss the role and mechanism of UCH-L1 in the pathogenesis of many diseases and, particularly, in lupus nephritis. Hence, we highlight the role of UCH-L1 in lupus nephritis.
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, People's Republic of China.|College of Life Science, Northwest University, Xi'an, 710069, People's Republic of China.
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Cui
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, People's Republic of China. xiexin@nwu.edu.cn.|College of Life Science, Northwest University, Xi'an, 710069, People's Republic of China. xiexin@nwu.edu.cn.|Institute for Integrated Medical Information (IIMI), Xi'an, 710018, People's Republic of China. xiexin@nwu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex; D015870:Gene Expression; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D008181:Lupus Nephritis / Q000209:etiology*; D058990:Molecular Targeted Therapy / Q000379:methods; D050199:Podocytes / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000235:genetics / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D000936:Antigen-Antibody Complex; D043222:Ubiquitin Thiolesterase
keywords: NF-κB; UCH-L1; lupus nephritis; podocyte