title: Assessment of Cardiovascular Risk Factors in Patients with Psoriasis.
abstract: Psoriasis is a chronic inflammatory skin disorder associated with increased cardiovascular risk. Aim of this work was to evaluate the association between psoriasis and chosen cardiovascular risk factors, echocardiographic parameters, and carotid intima-media thickness. A total of 50 patients with psoriasis and 50 controls were enrolled in the study. Psoriasis area severity index was calculated in the study group. Systolic and diastolic blood pressure, body mass index, waist circumference, lipids, fasting glucose, and D-dimer levels were assessed in all patients. In addition, echochardiographic parameters and carotid intima-media thickness were measured. Patients with psoriasis had higher blood pressure (P=0.001), elevated triglycerides (P=0.0218), lower high-density lipoprotein cholesterol (HDL-C) (P=0.0014), elevated D-dimer levels (p=0.0009), and were more frequently overweight (P=0.0198) in comparison to controls. There were no differences in echocardiographic parameters and carotid intima-media thickness between the psoriasis and control groups. Moreover, a positive correlation between psoriasis area severity index and blood pressure was observed (P=0.0088). The study confirmed that psoriasis is associated with increased cardiovascular risk. The association between psoriasis, intima-media thickness, and echocardiographic parameters should be evaluated in large prospective studies.
authors.forename: Olivia
authors.initials: O
authors.lastname: Komorowska
authors.forename: Michal
authors.initials: M
authors.lastname: Bohdan
authors.affiliation: Szczerkowska-Dobosz Aneta, MD, PhD, 7th Debinki St., 80-211 Gdansk, Poland; adobosz@gumed.edu.pl.
authors.forename: Aneta
authors.initials: A
authors.lastname: Szczerkowska-Dobosz
authors.forename: Dorota
authors.initials: D
authors.lastname: Rawicz-Zegrzda
authors.forename: Maria
authors.initials: M
authors.lastname: Dudziak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zdrojewski
authors.forename: Marcin
authors.initials: M
authors.lastname: Gruchala
authors.forename: Dorota
authors.initials: D
authors.lastname: Purzycka-Bohdan
authors.forename: Roman
authors.initials: R
authors.lastname: Nowicki
mesh_terms: D000328:Adult; D017677:Age Distribution; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D015897:Comorbidity; D016001:Confidence Intervals; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology*; D015994:Incidence; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011379:Prognosis; D011565:Psoriasis / Q000453:epidemiology* / Q000473:pathology; D012016:Reference Values; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D049629:Waist-Hip Ratio