title: Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology.
abstract: This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy, and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology, which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease. Although significant progress has been made in defining endotypes for asthma, definitions of endotypes for food and drug allergy or for anaphylaxis lag behind. Progress has been made in discovery of biomarkers to guide a precision medicine approach to treatment of food and drug allergy, but further validation and quantification of these biomarkers are needed to allow their translation into practice in the clinical management of allergic disease.
authors.affiliation: Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Muraro
authors.affiliation: Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: R F
authors.initials: RF
authors.lastname: Lemanske
authors.affiliation: Drug Hypersensitivity and Desensitization Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Castells
authors.affiliation: Allergy Unit, Regional University Hospital of Malaga-IBIMA, UMA, Malaga, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Torres
authors.affiliation: Division of Allergy & Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: D
authors.initials: D
authors.lastname: Khan
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: H-U
authors.initials: HU
authors.lastname: Simon
authors.affiliation: Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Bindslev-Jensen
authors.affiliation: Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: W
authors.initials: W
authors.lastname: Burks
authors.affiliation: Allergy Clinic, Copenhagen University Hospital at Gentofte Hospital, Copenhagen, Denmark.
authors.forename: L K
authors.initials: LK
authors.lastname: Poulsen
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Sampson
authors.affiliation: Klinik für Dermatologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Worm
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.|Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: K C
authors.identifier: http://orcid.org/0000-0002-2146-2955
authors.initials: KC
authors.lastname: Nadeau
mesh_terms: D017668:Age of Onset; D000485:Allergens / Q000276:immunology; D000707:Anaphylaxis / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D015415:Biomarkers; D015897:Comorbidity; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D010641:Phenotype; D057285:Precision Medicine / Q000379:methods; D012720:Severity of Illness Index
chemical_list: D000485:Allergens; D015415:Biomarkers
keywords: allergy; anaphylaxis; endotype; phenotype; precision medicine