title: Nuclear Import of Hepatitis B Virus Capsids and Genome.
abstract: Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus. The virus must have thus ways of transporting its DNA genome into this compartment. This review summarizes the data on hepatitis B virus genome transport and correlates the finding to those from other viruses.
authors.affiliation: Laboratoire de Microbiologie Fondamentale et Pathogénicité, University of Bordeaux, UMR 5234, F-33076 Bordeaux, France. lara.gallucci@u-bordeaux.fr.|CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, F-33076 Bordeaux, France. lara.gallucci@u-bordeaux.fr.
authors.forename: Lara
authors.initials: L
authors.lastname: Gallucci
authors.affiliation: Laboratoire de Microbiologie Fondamentale et Pathogénicité, University of Bordeaux, UMR 5234, F-33076 Bordeaux, France. michael.kann@u-bordeaux.fr.|CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, F-33076 Bordeaux, France. michael.kann@u-bordeaux.fr.|Centre Hospitalier Universitaire de Bordeaux, Service de Virologie, F-33076 Bordeaux, France. michael.kann@u-bordeaux.fr.
authors.forename: Michael
authors.initials: M
authors.lastname: Kann
mesh_terms: D021581:Active Transport, Cell Nucleus; D002213:Capsid / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism*; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D053586:Virus Internalization
chemical_list: D004279:DNA, Viral
keywords: genome release; hepatitis B virus; nuclear pore; nuclear transport; nucleoporin