title: Antidiabetic medications use trends in an Andalusian region from 2001 to 2014.
abstract: There is a widening range of antidiabetic medications available; however changes in consumption patterns remain poorly documented. The aim of this study is to analyze the evolution of consumption of antidiabetic medications during the period 2001-2014 in an Andalusian region.
  
  
  
  All antidiabetic medicines on the market were selected for analysis. Consumption data were obtained for the 15-year period and were expressed in defined daily doses (DDD) per 1000 inhabitants per day (DHD).
  
  
  
  During the study period consumption of insulins grew only a 2.2%, from 17.9 DHD to 18.3 DHD, while oral agents increased a 27.6%, from 41.3 DHD to 52.7 DHD. Consumption of sulfonylureas was gradually reduced from 30.1 DHD to 16.4 DHD but metformin (alone) usage increased from 4.3 DHD to 23.7 DHD, and was the most consumed agent in 2014. A rise in consumption of dipeptidyl peptidase-4 inhibitors and "other hypoglycemic agents" was also noticed. Overall expenditure in antidiabetic medications increased notably from 4.5 in 2001 to 14.4 million euros in 2014.
  
  
  
  We highlight the market uptake of antidiabetic drugs commercialized during the last decade; despite further exploration is needed to clarify the cost-benefit ratio of these new antidiabetic medicines.
authors.affiliation: Unidad Gestión Clínica de Farmacia Provincial de Granada, Distrito Sanitario Granada Metropolitano, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain.
authors.forename: Rocío
authors.initials: R
authors.lastname: López-Sepúlveda
authors.affiliation: Unidad Gestión Clínica de Farmacia Provincial de Granada, Distrito Sanitario Granada Metropolitano, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain. Electronic address: mariaa.garcia.lirola.sspa@juntadeandalucia.es.
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: García Lirola
authors.affiliation: Unidad Gestión Clínica de Farmacia Provincial de Granada, Distrito Sanitario Granada Metropolitano, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Espínola García
authors.affiliation: Unidad Gestión Clínica de Farmacia Provincial de Granada, Distrito Sanitario Granada Metropolitano, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain.
authors.forename: Jose María
authors.initials: JM
authors.lastname: Jurado Martínez
authors.affiliation: Unidad Gestión Clínica de Farmacia Provincial de Granada, Distrito Sanitario Granada Metropolitano, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain.
authors.forename: Salvadora
authors.initials: S
authors.lastname: Martín Sances
authors.affiliation: Unidad Gestión Clínica de Farmacia Provincial de Granada, Distrito Sanitario Granada Metropolitano, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Anaya Ordóñez
authors.affiliation: Unidad de Gestión Clínica de Farmacia Provincial de Granada, Complejo Hospitalario de Granada, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Cabeza Barrera
mesh_terms: D003132:Commerce / Q000191:economics / Q000639:trends; D003362:Cost-Benefit Analysis; D016208:Databases, Factual; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000191:economics; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000191:economics; D016527:Drug Costs / Q000639:trends; D011307:Drug Prescriptions; D017723:Drug Utilization Review; D005102:Health Expenditures / Q000639:trends; D006801:Humans; D007004:Hypoglycemic Agents / Q000191:economics / Q000627:therapeutic use*; D010818:Practice Patterns, Physicians' / Q000191:economics / Q000639:trends*; D012189:Retrospective Studies; D013030:Spain; D013997:Time Factors
chemical_list: D007004:Hypoglycemic Agents
keywords: Andalusia; Antidiabetic agents; Diabetes mellitus; Trends