title: Changes in body mass index during childhood and risk of various asthma phenotypes: a retrospective analysis.
abstract: It is known that asthma is related to obesity but also to small birthweight. The objective of this study was to clarify this issue by assessing the putative relationship between the changes in corpulence between birth and childhood as assessed by body mass index (BMI) and asthma phenotypes.
  
  
  
  The following status in corpulence was assessed in 7781 schoolchildren using quartile of BMI at birth and at around 10 (9-11 years): underweight at birth and at around 10, underweight at birth and overweight at around 10, overweight at birth and underweight at around 10, overweight at birth and at around 10, and the reference group constituted by all the other children in whom corpulence changes were not extreme. Determination of asthma phenotypes (allergic, non-allergic, and exercise-induced asthma) was based on a clinical examination including skin prick tests, an exercise challenge test, and a questionnaire.
  
  
  
  The risk of allergic asthma was higher in children with persistent underweight, children with persistent overweight, and children becoming markedly more corpulent. In boys, the risk of allergic asthma was significantly higher for the less corpulent children at birth, regardless of whether they remained so or become overweight. In girls, the risk of allergic asthma was significantly higher in those with persistent overweight. There were no significant associations between BMI changes and non-allergic and exercise-induced asthma.
  
  
  
  We observed that some extreme changes in BMI, persistent underweight, and persistent overweight in childhood increased the risk of allergic asthma.
authors.affiliation: Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France.|Département de Médecine générale, Faculté de Médecine, Paris UPMC, Université Paris 6, Paris, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Chastang
authors.affiliation: Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France.
authors.forename: Nour
authors.identifier: 0000-0001-6165-3935
authors.initials: N
authors.lastname: Baiz
authors.affiliation: Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France.|Département de Médecine générale, Faculté de Médecine, Paris UPMC, Université Paris 6, Paris, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Parnet
authors.affiliation: Département de Médecine générale, Faculté de Médecine, Paris UPMC, Université Paris 6, Paris, France.
authors.forename: Jean Sébastien
authors.initials: JS
authors.lastname: Cadwallader
authors.affiliation: Service de pneumologie, CHU de Strasbourg, Strasbourg, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: De Blay
authors.affiliation: Service de pneumologie, CHU de Clermont-Ferrand, Clermont-Ferrand, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Caillaud
authors.affiliation: Service de pneumologie, CHU de Marseille, Marseille, France.
authors.forename: Denis André
authors.initials: DA
authors.lastname: Charpin
authors.affiliation: Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France.
authors.forename: John
authors.initials: J
authors.lastname: Dwyer
authors.affiliation: Service de pneumologie et allergologie, CHU de Reims, Reims, France.
authors.forename: François
authors.initials: F
authors.lastname: Lavaud
authors.affiliation: Service de pneumologie et affections respiratoires, CHU de Bordeaux, Bordeaux, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Raherison
authors.affiliation: Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France.|Département de Médecine générale, Faculté de Médecine, Paris UPMC, Université Paris 6, Paris, France.
authors.forename: Gladys
authors.initials: G
authors.lastname: Ibanez
authors.affiliation: Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France.
authors.forename: Isabella
authors.initials: I
authors.lastname: Annesi-Maesano
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000209:etiology*; D001724:Birth Weight; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000150:complications*; D010641:Phenotype; D012307:Risk Factors; D012882:Skin Tests; D011795:Surveys and Questionnaires; D013851:Thinness / Q000150:complications*
keywords: 
  BMI
  ; allergic asthma; asthma; corpulence; obesity