title: The INSR rs2059806 single nucleotide polymorphism, a genetic risk factor for vascular and metabolic disease, associates with pre-eclampsia.
abstract: Pre-eclampsia is a risk factor for later life vascular and metabolic diseases. This study postulates that this reflects a common genetic cause, and investigates whether the INSR rs2059806 single nucleotide polymorphism (SNP) (a risk factor for essential hypertension, type 2 diabetes and metabolic syndrome) is also associated with pre-eclampsia. The association of INSR rs2059806 with pre-eclampsia was tested in two cohorts - a Caucasian case control group (123 pre-eclamptic mother-father-baby trios and 1185 mother-father-baby trios from uncomplicated pregnancies) and an independent cohort of Sinhalese women (175 women with pre-eclampsia and 171 women with uncomplicated pregnancies). In the Caucasian cohort, the prevalence of the INSR rs2059806 AA genotype was greater among pre-eclamptic women compared with the uncomplicated pregnancies (12.7% versus 4.7%, OR[95%CI] = 3.1[1.6-5.8], P = 0.0003). In the Sinhalese cohort, maternal INSR rs2059806 AA genotype was greater among pre-eclamptic women who delivered small for gestational age infants compared with the uncomplicated pregnancies (10.8% versus 4.2%, OR[95%CI] = 2.8[1.0-7.4], P = 0.03). Thus, it was found that the INSR rs2059806 SNP is also associated with pre-eclampsia phenotypes in two independent cohorts suggesting that genetic susceptibility may be implicated in the link between pre-eclampsia and subsequent vascular and metabolic diseases.
authors.affiliation: Discipline of Obstetrics and Gynaecology, School of Medicine and Robinson Research Institute, The University of Adelaide, Adelaide, Australia. Electronic address: prabha.andraweera@adelaide.edu.au.
authors.forename: Prabha H
authors.initials: PH
authors.lastname: Andraweera
authors.affiliation: Discipline of Obstetrics and Gynaecology, School of Medicine and Robinson Research Institute, The University of Adelaide, Adelaide, Australia.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Gatford
authors.affiliation: Discipline of Obstetrics and Gynaecology, School of Medicine and Robinson Research Institute, The University of Adelaide, Adelaide, Australia; Women's and Children's Division, Lyell McEwin Hospital, Elizabeth Vale, Australia.
authors.forename: Gustaaf A
authors.initials: GA
authors.lastname: Dekker
authors.affiliation: Discipline of Obstetrics and Gynaecology, School of Medicine and Robinson Research Institute, The University of Adelaide, Adelaide, Australia.
authors.forename: Shalem
authors.initials: S
authors.lastname: Leemaqz
authors.affiliation: Human Genetics Unit, Faculty of Medicine, The University of Colombo, Colombo, Sri Lanka.
authors.forename: Rohan W
authors.initials: RW
authors.lastname: Jayasekara
authors.affiliation: Human Genetics Unit, Faculty of Medicine, The University of Colombo, Colombo, Sri Lanka.
authors.forename: Vajira H W
authors.initials: VHW
authors.lastname: Dissanayake
authors.affiliation: Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand.
authors.forename: Lesley
authors.initials: L
authors.lastname: McCowan
authors.affiliation: Discipline of Obstetrics and Gynaecology, School of Medicine and Robinson Research Institute, The University of Adelaide, Adelaide, Australia.
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
mesh_terms: D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011972:Receptor, Insulin / Q000235:genetics*; D012307:Risk Factors; D014652:Vascular Diseases / Q000235:genetics*
chemical_list: D011972:Receptor, Insulin
keywords: INSR; Pre-eclampsia; SNP; Single nucleotide polymorphism; rs2059806