title: Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction.
abstract: A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis. The method uses the 1,3-dipolar cycloaddition reaction betweenN-alkylvinylindole/indazole and azomethine ylides, prepared in situ from cyclic/acyclic amino acids. The 1,3-dipolar cycloaddition proceeds efficiently under thermal conditions to afford the regio- and stereospecific cyclic adducts.
authors.affiliation: East Point College of Engineering and Technology, VisvesvarayaTechnological University, Aavalahalli, Bangalore-560 049, India.
authors.forename: Manjunatha
authors.initials: M
authors.lastname: Narayanarao
authors.affiliation: Department of Studies and Research in Chemistry, Vijayanagara Sri Krishnadevaraya University, Bellary-583105, India.
authors.forename: Lokesh
authors.initials: L
authors.lastname: Koodlur
authors.affiliation: Department of Chemistry, University College of Science, Tumkur University, BH Road, Tumakuru-572103 India.
authors.forename: Vijayakumar G
authors.initials: VG
authors.lastname: Revanasiddappa
authors.affiliation: Department of Studies and Research in Chemistry, Vijayanagara Sri Krishnadevaraya University, Bellary-583105, India.
authors.forename: Subramanya
authors.initials: S
authors.lastname: Gopal
authors.affiliation: East Point College of Engineering and Technology, VisvesvarayaTechnological University, Aavalahalli, Bangalore-560 049, India.
authors.forename: Susmita
authors.initials: S
authors.lastname: Kamila
keywords: 5-vinylindazole; 5-vinylindole; L-proline; ninhydrin; sarcosine; spiropyrrolidine