title: Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats.
abstract: OBJECTIVE
  We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group.
  
  
  METHODS
  Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test.
  
  
  RESULTS
  In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p<0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p<0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p<0.05).
  
  
  CONCLUSIONS
  Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity.
authors.affiliation: Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, SP, Brazil.
authors.forename: Fabio Santos
authors.initials: FS
authors.lastname: Lira
authors.affiliation: Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, Brazil.
authors.forename: Andrea Maculano
authors.initials: AM
authors.lastname: Esteves
authors.affiliation: Laboratory of Research in Clinical Nutrition and Sports (Labince), Nutrition Faculty (FANUT), Federal University of Goias (UFG), Goiânia, GO, Brazil.
authors.forename: Gustavo Duarte
authors.initials: GD
authors.lastname: Pimentel
authors.affiliation: Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: José Cesar
authors.initials: JC
authors.lastname: Rosa
authors.affiliation: Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, Brazil.
authors.forename: Miriam Kannebley
authors.initials: MK
authors.lastname: Frank
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil.
authors.forename: Melise Oliveira
authors.initials: MO
authors.lastname: Mariano
authors.affiliation: Laboratory of Neurosciences, National Institute for Translational Medicine, and Center of Excellence in Applied Neurosciences of Santa Catarina, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.
authors.forename: Josiane
authors.initials: J
authors.lastname: Budni
authors.affiliation: Laboratory of Neurosciences, National Institute for Translational Medicine, and Center of Excellence in Applied Neurosciences of Santa Catarina, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.affiliation: Departamento de Biociências, Universidade Federal de São Paulo, Santos, Brazil.
authors.forename: Ronaldo Vagner Dos
authors.initials: RV
authors.lastname: Santos
authors.affiliation: Departamento de Esportes, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
keywords: Doxorubicin; Locomotor activity; Rats; Sleep