title: Associations of objective physical activity with insulin sensitivity and circulating adipokine profile: the Framingham Heart Study.
abstract: The purpose of this study was to explore the relation of physical activity (PA) and sedentary time (SED) to insulin sensitivity and adipokines. We assessed PA and SED using Actical accelerometers and insulin resistance (HOMA-IR) in 2109 participants (free of type 1 and 2 diabetes mellitus) from Framingham Generation 3 and Omni 2 cohorts (mean age 46 years, 54% women). Systemic inflammation (C-reactive protein [CRP]) and circulating adipokines were measured 6 years earlier. Steps per day, moderate-to-vigorous PA (MVPA) and SED per wear time (%SED) were predictor variables in multivariable regression analyses, with HOMA-IR, CRP and circulating adipokines as outcome measures. We reported that higher MVPA and more steps per day were associated with lower HOMA-IR, adjusting for %SED (β = -0.036, P = 0.002; β = -0.041, P = 0.005). Steps were inversely associated with CRP, but were directly associated with insulin-like growth factor (IGF)-1 levels (β = -0.111, P = 0.002; β = 3.293, P = 0.007). %SED was positively associated with HOMA-IR (β = 0.033, P < 0.0001), but non-significant after adjusting for MVPA (P = 0.13). %SED was associated with higher ratio of leptin/leptin receptor (sOB-R) and higher adipocyte fatty acid-binding protein (FABP)4 (β = 0.096, P < 0.0001; β = 0.593, P = 0.002). Our findings suggest differential influences of PA vs. SED on metabolic pathways, with PA modulating insulin resistance and inflammation, whereas SED influences FABPs.
authors.affiliation: Sections of Preventive Medicine and Epidemiology, and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.|Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.|Framingham Heart Study, Framingham, MA, USA.
authors.forename: N L
authors.initials: NL
authors.lastname: Spartano
authors.affiliation: Framingham Heart Study, Framingham, MA, USA.|Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Stevenson
authors.affiliation: Sections of Preventive Medicine and Epidemiology, and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.|Framingham Heart Study, Framingham, MA, USA.|Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
authors.forename: V
authors.initials: V
authors.lastname: Xanthakis
authors.affiliation: Framingham Heart Study, Framingham, MA, USA.|Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Larson
authors.affiliation: Framingham Heart Study, Framingham, MA, USA.|Department of Internal Medicine, Glostrup Hospital, Glostrup, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Andersson
authors.affiliation: Framingham Heart Study, Framingham, MA, USA.|Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Murabito
authors.affiliation: Sections of Preventive Medicine and Epidemiology, and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.|Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.|Framingham Heart Study, Framingham, MA, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Vasan
mesh_terms: D054392:Adipokines / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D054411:Receptors, Leptin / Q000097:blood; D012044:Regression Analysis; D057185:Sedentary Behavior
chemical_list: D054392:Adipokines; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D007328:Insulin; C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein
keywords: Epidemiology; exercise; inflammation; sedentary time