title: Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms.
abstract: Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabolic processes resulting in impaired arterial health. Subsequently, these vascular impairments directly and indirectly contribute to the development of CVD.
authors.affiliation: 1Research Institute for Sport and Exercise Science, Liverpool John Moore's University, Liverpool, United Kingdom; and 2Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Sophie
authors.initials: S
authors.lastname: Carter
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Hartman
authors.forename: Sophie
authors.initials: S
authors.lastname: Holder
authors.forename: Dick H
authors.initials: DH
authors.lastname: Thijssen
authors.forename: Nicola D
authors.initials: ND
authors.lastname: Hopkins
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D012307:Risk Factors; D057185:Sedentary Behavior
chemical_list: D001786:Blood Glucose