title: Citrate functionalized Mn3O4in nanotherapy of hepatic fibrosis by oral administration.
abstract: OBJECTIVE
  To test the potential of orally administered citrate functionalized Mn3O4nanoparticles (C-Mn3O4NPs) as a therapeutic agent against hepatic fibrosis and associated chronic liver diseases.
  
  
  METHODS
  C-Mn3O4NPs were synthesized and the pH dependent antioxidant mechanism was characterized byin vitrostudies. CCl4intoxicated mice were orally treated with C-Mn3O4NPs to test itsin vivoantioxidant and antifibrotic ability.
  
  
  RESULTS
  We demonstrated ultrahigh efficacy of the C-Mn3O4NPs in treatment of chronic liver diseases such as hepatic fibrosis and cirrhosis in mice compared with conventional medicine silymarin without any toxicological implications.
  
  
  CONCLUSIONS
  These findings may pave the way for practical clinical use of the NPs as safe medication of chronic liver diseases associated with fibrosis and cirrhosis in human subjects.
authors.affiliation: Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India; Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India; Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India.
authors.forename: Nabarun
authors.initials: N
authors.lastname: Polley
authors.affiliation: Research & Development Division, Dey's Medical Stores (Mfg.) Ltd., 62, Bondel Road, Ballygunge, Kolkata 700019, India; Research & Development Division, Dey's Medical Stores (Mfg.) Ltd., 62, Bondel Road, Ballygunge, Kolkata 700019, India.
authors.forename: Soumendra
authors.initials: S
authors.lastname: Darbar
authors.affiliation: Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India; Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India.
authors.forename: Damayanti
authors.initials: D
authors.lastname: Bagchi
authors.affiliation: Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India; Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India.
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Pal
keywords: fibrosis; hepatoprotective; nanomedicine; nanotherapy; oral administration of drug