title: Safety assessment of xylan by a 90-day feeding study in rats.
abstract: Xylans are present naturally in various plants and have important uses in nutrition, food, novel material and biotechnology; however, to date, data regarding their systemic toxicity and safety evaluation is still limited. This study investigated the potential toxicity of xylan from sugarcane bagasse by a subchronic toxicity study in rats. A total of 80 male and female rats were fed with diets containing 10%, 5%, 2.5% and 0% (control) xylan for 90 days. A toxicological assessment was performed including mortality, body and organ weights, food consumption, blood biochemistry, hematology, urinalysis, gross necropsy and histopathological examinations. There were no signs of toxicity and treatment-related changes in rats treated with xylan. The no-observed-adverse-effect levels (NOAEL) of xylan were 9.0 g kg-1bw for males and 10.6 g kg-1bw for females of rats under this experimental condition, respectively.
authors.affiliation: Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China. Electronic address: qinguangqiu@hotmail.com.
authors.forename: Guangqiu
authors.initials: G
authors.lastname: Qin
authors.affiliation: Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
authors.forename: Pingjing
authors.initials: P
authors.lastname: Wen
authors.affiliation: Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
authors.forename: Yanwu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
authors.forename: Lujuan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
authors.forename: Huili
authors.initials: H
authors.lastname: Liang
authors.affiliation: Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
authors.forename: Huiyan
authors.initials: H
authors.lastname: Qin
authors.affiliation: School of Environment and Sustainability, University of Saskatchewan, Saskatoon, SK S7N5B3, Canada.
authors.forename: Song
authors.initials: S
authors.lastname: Tang
authors.affiliation: Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002482:Cellulose / Q000737:chemistry*; D005260:Female; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D051381:Rats; D017207:Rats, Sprague-Dawley; D031786:Saccharum; D059550:Toxicity Tests, Subchronic; D014990:Xylans / Q000633:toxicity*
chemical_list: D014990:Xylans; D002482:Cellulose; C027433:bagasse
keywords: Animal study; Histopathological examination; NOAEL; Subchronic toxicity