title: [A Case of Primary Acinic Cell Carcinoma(ACC)of the Breast].
abstract: A49 -year-old woman presented with a 3.5 cm mass in her right breast. Mammography revealed a lobular mass with poorly defined margins and no microcalcification. Ultrasonography showed a hypoechoic mass with an irregular margin. The tumor was diagnosed as breast carcinoma using a core needle biopsy. The patient underwent a modified radical mastectomy with sentinel lymph node biopsy, and received adjuvant chemotherapy. The tumor consisted of 2 types of carcinoma. The center of the tumor was solid-tubular carcinoma, and the periphery was acinic cell carcinoma(ACC). Histopathologically, the neoplastic cells of the periphery were characterized by widespread acinic cell-like differentiation with a eosinophilic granular or clear cytoplasm, resembling acinic cells of the parotid gland(t3, f[+], ly0, v0, n0, stage II B). Immunohistochemically, the specimens tested positive for salivary gland amylase, and negative for collagen type IV , ER, PgR, and HER2. We administered UFT as adjuvant chemotherapy. Eight months after surgery, local recurrence was observed. ACC of the breast is rare, and has been reported to have a good prognosis. Further investigations are needed to elucidate its true histogenesis the appropriate treatment.
authors.affiliation: Dept. of Surgery, Okayama Rosai Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawai
authors.forename: Ryoma
authors.initials: R
authors.lastname: Sugimoto
authors.forename: Norichika
authors.initials: N
authors.lastname: Iga
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Ikeda
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Yoshida
authors.forename: Naohisa
authors.initials: N
authors.lastname: Waki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nishi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yamashita
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D018267:Carcinoma, Acinar Cell / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D005641:Tegafur; D014498:Uracil