title: Resistance diagnosis and the changing epidemiology of antibiotic resistance.
abstract: Widespread adoption of point-of-care resistance diagnostics (POCRD) reduces ineffective antibiotic use but could increase overall antibiotic use. Indeed, in the context of a standard susceptible-infected epidemiological model with a single antibiotic, POCRD accelerates the rise of resistance in the disease-causing bacterial population. When multiple antibiotics are available, however, POCRD may slow the rise of resistance even as more patients receive antibiotic treatment, belying the conventional wisdom that antibiotics are "exhaustible resources" whose increased use necessarily promotes the rise of resistance.
authors.affiliation: Fuqua School of Business and Economics Department, Duke University, Durham, North Carolina.
authors.forename: David
authors.initials: D
authors.lastname: McAdams
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy; D024881:Drug Resistance, Bacterial; D006801:Humans; D019095:Point-of-Care Systems
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotic resistance; economic epidemiology; point-of-care diagnosis; resistance-targeted treatment