title: Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy.
abstract: Focal cortical dysplasia is a congenital abnormality of cortical development and the leading cause of surgically remediable drug-resistant epilepsy in children. Post-surgical outcome is improved by presurgical lesion detection on structural MRI. Automated computational techniques have improved detection of focal cortical dysplasias in adults but have not yet been effective when applied to developing brains. There is therefore a need to develop reliable and sensitive methods to address the particular challenges of a paediatric cohort. We developed a classifier using surface-based features to identify focal abnormalities of cortical development in a paediatric cohort. In addition to established measures, such as cortical thickness, grey-white matter blurring, FLAIR signal intensity, sulcal depth and curvature, our novel features included complementary metrics of surface morphology such as local cortical deformation as well as post-processing methods such as the "doughnut" method - which quantifies local variability in cortical morphometry/MRI signal intensity, and per-vertex interhemispheric asymmetry. A neural network classifier was trained using data from 22 patients with focal epilepsy (mean age = 12.1 ± 3.9, 9 females), after intra- and inter-subject normalisation using a population of 28 healthy controls (mean age = 14.6 ± 3.1, 11 females). Leave-one-out cross-validation was used to quantify classifier sensitivity using established features and the combination of established and novel features. Focal cortical dysplasias in our paediatric cohort were correctly identified with a higher sensitivity (73%) when novel features, based on our approach for detecting local cortical changes, were included, when compared to the sensitivity using only established features (59%). These methods may be applicable to aiding identification of subtle lesions in medication-resistant paediatric epilepsy as well as to the structural analysis of both healthy and abnormal cortical development.
authors.affiliation: Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children, London, UK.
authors.forename: Sophie
authors.initials: S
authors.lastname: Adler
authors.affiliation: Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Brain Mapping Unit, Institute of Psychiatry, University of Cambridge, UK.
authors.forename: Konrad
authors.initials: K
authors.lastname: Wagstyl
authors.affiliation: Great Ormond Street Hospital for Children, London, UK.
authors.forename: Roxana
authors.initials: R
authors.lastname: Gunny
authors.affiliation: Brain Mapping Unit, Institute of Psychiatry, University of Cambridge, UK.
authors.forename: Lisa
authors.initials: L
authors.lastname: Ronan
authors.affiliation: Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Carmichael
authors.affiliation: Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children, London, UK.
authors.forename: J Helen
authors.initials: JH
authors.lastname: Cross
authors.affiliation: Brain Mapping Unit, Institute of Psychiatry, University of Cambridge, UK; Cambridge & Peterborough NHS Foundation Trust, Cambridgeshire, UK.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Fletcher
authors.affiliation: Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children, London, UK.
authors.forename: Torsten
authors.initials: T
authors.lastname: Baldeweg
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications* / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D000069550:Machine Learning; D008279:Magnetic Resonance Imaging; D008297:Male; D065703:Malformations of Cortical Development, Group I / Q000000981:diagnostic imaging* / Q000209:etiology*; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen
keywords: AUC, area under the curve; Automated classification; FCD; FCD, focal cortical dysplasia; FLAIR, fluid-attenuated inversion recovery; Intractable epilepsy; LCD, local cortical deformation; LGI, local gyrification index; PCA, principal component analysis; Paediatric; ROC, receiver operator characteristic; Structural MRI