title: Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation.
abstract: Hair cells (HCs) are the sensory preceptor cells in the inner ear, which play an important role in hearing and balance. The HCs of organ of Corti are susceptible to noise, ototoxic drugs, and infections, thus resulting in permanent hearing loss. Recent approaches of HCs regeneration provide new directions for finding the treatment of sensor neural deafness. To have normal hearing function, the regenerated HCs must be reinnervated by nerve fibers and reform ribbon synapse with the dendrite of spiral ganglion neuron through nerve regeneration. In this review, we discuss the research progress in HC regeneration, the synaptic plasticity, and the reinnervation of new regenerated HCs in mammalian inner ear.
authors.affiliation: Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
authors.forename: Xiaoling
authors.identifier: 0000-0002-6550-7502
authors.initials: X
authors.lastname: Lu
authors.affiliation: Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
authors.forename: Yilai
authors.identifier: 0000-0001-5668-5107
authors.initials: Y
authors.lastname: Shu
authors.affiliation: Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
authors.forename: Mingliang
authors.identifier: 0000-0001-8010-5598
authors.initials: M
authors.lastname: Tang
authors.affiliation: Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Key Laboratory of Hearing Medicine of NHFPC, Shanghai 200031, China; Shanghai Engineering Research Centre of Cochlear Implant, Shanghai 200031, China; The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
authors.forename: Huawei
authors.identifier: 0000-0001-7673-0884
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D006198:Hair Cells, Auditory / Q000166:cytology*; D034381:Hearing Loss / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000378:metabolism*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*