title: Preprocedural C-Reactive Protein Predicts Outcomes after Primary Percutaneous Coronary Intervention in Patients with ST-elevation Myocardial Infarction a systematic meta-analysis.
abstract: Risk assessment in patients with acute coronary syndromes (ACS) is critical in order to provide adequate treatment. We performed a systematic meta-analysis to assess the predictive role of serum C-reactive protein (CRP) in patients with ST-segment elevation myocardial infarction (STEMI), treated with primary percutaneous coronary intervention (PPCI). We included 7 studies, out of 1,033 studies, with a total of 6,993 patients with STEMI undergoing PPCI, which were divided in the high or low CRP group, according to the validated cut-off values provided by the corresponding CRP assay. High CRP values were associated with increased in-hospital and follow-up all-cause mortality, in-hospital and follow-up major adverse cardiac events (MACE), and recurrent myocardial infarction (MI). The pre-procedural CRP predicted in-hospital target vessel revascularization (TVR), but was not associated with acute/subacute and follow-up in-stent restenosis (ISR), and follow-up TVR. Thus, pre-procedural serum CRP could be a valuable predictor of global cardiovascular risk, rather than a predictor of stent-related complications in patients with STEMI undergoing PPCI. This biomarker might have the potential to improve the management of these high-risk patients.
authors.affiliation: University Hospital Essen, Medical Faculty, West German Heart and Vascular Center, Department of Cardiology and Vascular Diseases, Hufelandstr. 55, 45147 Essen, Germany.|University of Medicine and Pharmacy Carol Davila - University and Emergency Hospital, Cardiac Research Unit, Splaiul Independentei 169, 050098 Bucharest, Romania.
authors.forename: Raluca-Ileana
authors.initials: RI
authors.lastname: Mincu
authors.affiliation: University Hospital Essen, Medical Faculty, West German Heart and Vascular Center, Department of Cardiology and Vascular Diseases, Hufelandstr. 55, 45147 Essen, Germany.
authors.forename: Rolf Alexander
authors.initials: RA
authors.lastname: Jánosi
authors.affiliation: University of Medicine and Pharmacy Carol Davila - University and Emergency Hospital, Cardiac Research Unit, Splaiul Independentei 169, 050098 Bucharest, Romania.
authors.forename: Dragos
authors.initials: D
authors.lastname: Vinereanu
authors.affiliation: University Hospital Essen, Medical Faculty, West German Heart and Vascular Center, Department of Cardiology and Vascular Diseases, Hufelandstr. 55, 45147 Essen, Germany.
authors.forename: Tienush
authors.initials: T
authors.lastname: Rassaf
authors.affiliation: University Hospital Essen, Medical Faculty, West German Heart and Vascular Center, Department of Cardiology and Vascular Diseases, Hufelandstr. 55, 45147 Essen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Totzeck
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D009204:Myocardial Revascularization / Q000401:mortality; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000401:mortality; D017594:Publication Bias; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D015607:Stents
chemical_list: D002097:C-Reactive Protein