title: Functionally relevant proteins in Plasmodium falciparum host cell invasion.
abstract: A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite survival and highlights the conserved amino acid sequences of the most important proteins involved in sporozoite invasion of hepatocytes and merozoite invasion of red blood cells. Conserved high activity binding peptides are located in such proteins' functionally strategic sites, whose functions are related to receptor binding, nutrient and protein transport, enzyme activity and molecule-molecule interactions. They are thus excellent targets for vaccine development as they block proteins binding function involved in invasion and also their biological function.
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.|Universidad Nacional de Colombia, Bogotá DC, Colombia.
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Patarroyo
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.|Universidad de Ciencias Aplicadas y Ambientales (UDCA), Bogotá, Colombia.
authors.forename: Martha P
authors.initials: MP
authors.lastname: Alba
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.
authors.forename: Rocío
authors.initials: R
authors.lastname: Rojas-Luna
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.|Universidad del Rosario, Bogotá DC, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Bermudez
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.
authors.forename: Jorge
authors.initials: J
authors.lastname: Aza-Conde
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000378:metabolism*; D018360:Crystallography, X-Ray; D015195:Drug Design; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology*; D022781:Hepatocytes / Q000276:immunology / Q000469:parasitology*; D054884:Host-Pathogen Interactions; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D017780:Malaria Vaccines / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D017780:Malaria Vaccines
keywords: cHABP; invasion-proteins; malaria; merozoite; sporozoite; vaccine