title: Bleeding risk in endoscopic retrograde cholangiopancreatography. Impact of the use of antithrombotic drugs.
abstract: OBJECTIVE
  To analyze the risk factors for hemorrhage during endoscopic retrograde cholangiopancreatography and the impact of antithrombotic drugs.
  
  
  METHODS
  Data sources: papers indexed in PubMed have been reviewed, as well as those found during the analysis of the bibliography of meta-analysis and reviews.
  
  
  METHODS
  the references have been firstly evaluated by review of the abstract. After selecting the most significant articles (mainly randomized trials and well-designed case series) these have been deeply analyzed. Evaluation of the studies and synthesis: criteria by the Oxford Centre for Evidence-Based Medicine have been used for the analysis of the references and elaboration of evidence levels.
  
  
  RESULTS
  Seven hundred and sixty-five references were found, 753 in PubMed and the Cochrane Library. Twelve studies were selected during the analysis of other published articles (systematic reviews, meta-analysis and clinical practice guidelines). After analyzing the title or the abstract, 655 studies were excluded. Finally, 83 high quality trials or descriptive studies have been included in the analysis.
  
  
  CONCLUSIONS
  Seven conclusions regarding the risk factors for bleeding and the impact of antithrombotic drugs have been defined.
authors.affiliation: Digestivo/endocopias, Hospital Clínico Universitario Virgen de la Arrixaca, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Alberca de Las Parras
authors.affiliation: Unidad de Gestión Clínica digestivo, Hospital Clínico Universitario Virgen de la Arrixaca.
authors.forename: Juan
authors.initials: J
authors.lastname: Egea Valenzuela
authors.affiliation: Unidad de Gestión Clínica Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca.
authors.forename: Fernando
authors.initials: F
authors.lastname: Carballo Álvarez
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006470:Hemorrhage / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors