title: Self-assembly of ultra-small micelles from amphiphilic lipopeptoids.
abstract: Poly(N-substituted glycine) "peptoids" constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomimetic nanospheres.
authors.affiliation: WestCHEM/Department of Pure & Applied Chemistry, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK. Aaron.Lau@strath.ac.uk.
authors.forename: King Hang Aaron
authors.identifier: http://orcid.org/0000-0003-3676-9228
authors.initials: KH
authors.lastname: Lau
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK. I.W.Hamley@reading.ac.uk.
authors.forename: Valeria
authors.initials: V
authors.lastname: Castelletto
authors.affiliation: EPSRC Doctoral Training Centre in Continuous Manufacturing and Crystallisation, Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose Street, Glasgow, G1 1XJ, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kendall
authors.affiliation: Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose Street, Glasgow, G1 1XJ, UK.
authors.forename: Jan
authors.initials: J
authors.lastname: Sefcik
authors.affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK. I.W.Hamley@reading.ac.uk.
authors.forename: Ian W
authors.identifier: http://orcid.org/0000-0002-4549-0926
authors.initials: IW
authors.lastname: Hamley
authors.affiliation: Department of Applied Physics, Aalto University School of Science, P.O. Box 15100, FI-00076, Aalto, Finland.
authors.forename: Mehedi
authors.initials: M
authors.lastname: Reza
authors.affiliation: Department of Applied Physics, Aalto University School of Science, P.O. Box 15100, FI-00076, Aalto, Finland.
authors.forename: Janne
authors.initials: J
authors.lastname: Ruokolainen
mesh_terms: D005998:Glycine / Q000031:analogs & derivatives*; D008055:Lipids / Q000737:chemistry*; D055666:Lipopeptides / Q000737:chemistry; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D034444:Peptoids / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D008055:Lipids; D055666:Lipopeptides; D008823:Micelles; D034444:Peptoids; D013501:Surface-Active Agents; D005998:Glycine