title: SWI/SNF complex in cancer.
abstract: Four studies in this issue report new mechanisms underlying the function of the chromatin remodeling SWI/SNF complex in controlling gene expression and suppressing tumor development, providing valuable insights into the treatment of cancers harboring mutations in genes encoding SWI/SNF complex subunits.
authors.affiliation: Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, New York, USA.
authors.forename: Chao
authors.identifier: http://orcid.org/0000-0003-0982-8122
authors.initials: C
authors.lastname: Lu
authors.affiliation: Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, New York, USA.
authors.forename: C David
authors.initials: CD
authors.lastname: Allis
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008869:Microtubule-Associated Proteins; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D063146:Polycomb-Group Proteins / Q000235:genetics* / Q000378:metabolism; D000071796:SMARCB1 Protein / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: C511511:Arid1a protein, mouse; C000612244:Arid1b protein, mouse; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C495328:Feo protein, Drosophila; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D063146:Polycomb-Group Proteins; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; C445179:SWI-SNF-B chromatin-remodeling complex; D014157:Transcription Factors; D011495:Histone-Lysine N-Methyltransferase; C524066:PRC2 protein, Drosophila