title: DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori.
abstract: Helicobacter pylori is the most common bacterial infection worldwide, and virtually all infected persons develop co-existing gastritis. H. pylori is able to send and receive signals from the gastric mucosa, which enables both host and microbe to engage in a dynamic equilibrium. In order to persist within the human host, H. pylori has adopted dichotomous strategies to both induce inflammation as a means of liberating nutrients while simultaneously tempering the immune response to augment its survival. Toll-like receptors (TLRs) and Nod proteins are innate immune receptors that are present in epithelial cells and represent the first line of defense against pathogens. To ensure persistence, H. pylori manipulates TLR-mediated defenses using strategies that include rendering its LPS and flagellin to be non-stimulatory to TLR4 and TLR5, respectively; translocating peptidoglycan into host cells to induce NOD1-mediated anti-inflammatory responses; and translocating DNA into host cells to induce TLR9 activation.
authors.affiliation: Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Matthew Gordon
authors.initials: MG
authors.lastname: Varga
authors.affiliation: Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. Richard.Peek@Vanderbilt.edu.|Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. Richard.Peek@Vanderbilt.edu.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Peek
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology; D016481:Helicobacter Infections / Q000235:genetics / Q000378:metabolism / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004269:DNA, Bacterial; D051193:Toll-Like Receptors
keywords: Cag T4SS; Helicobacter pylori; Toll-Like receptor 9