title: Association Study of Klotho Gene Polymorphism With Calcium Oxalate Stones in The Uyghur Population of Xinjiang, China.
abstract: OBJECTIVE
  The aim of the present study was to investigate the correlation between Klotho gene polymorphisms andcalcium oxalate stones in Xinjiang Uyghur people.
  
  
  METHODS
  We compared 128 patients with calcium oxalate stones (case group) and 94 healthypeople (control group), detected the genotype and allele distributions of single-nucleotide polymorphisms (SNPs)of the Klotho gene (rs3752472, rs650439, and rs1207568) by reverse transcription polymerase chain reaction.
  
  
  RESULTS
  The distributions of the genotype and allele frequencies of the SNPs were consistent with the Hardy-Weinberg equilibrium in the two groups. There were statistically significant differences between the genotype andallele distributions of rs3752472 between the case and control groups; the allele frequencies in the case/controlgroups were C = 240 (93.7%)/151 (80.3%) and T = 16 (6.3%)/37 (19.7%). There was no statistically significantdifference in the genotype distribution of rs650439 between the case and control groups, but there was a differencein the allele distribution; the allele frequencies in the case/control groups were A = 202 (78.9%)/143 (57.2%) andT = 54 (21.1%)/107 (42.8%). There were no statistically significant differences in genotype and allele distributionsbetween the case and control groups of rs1207568; the allele frequencies in the case/control groups were C = 194(71.3%)/145 (77.1%) and T = 78 (28.7%)/43 (22.9%). In rs3752472, the risk for patients with the C and A allelesincreased by 3.675 and 2.799 times, respectively.
  
  
  CONCLUSIONS
  The rs3752472 and rs650439 SNPs are related to the risk of calcium oxalate stones in Xinjiang Uyghurpeople, and might be one of the risk factors.
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi ,Xinjiang, China. abdusamat3787@126.com.
authors.forename: Abdusamat
authors.initials: A
authors.lastname: Ali
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi ,Xinjiang, China.
authors.forename: Halmurat
authors.initials: H
authors.lastname: Tursun
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi ,Xinjiang, China.
authors.forename: Alim
authors.initials: A
authors.lastname: Talat
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi ,Xinjiang, China.
authors.forename: Akpar
authors.initials: A
authors.lastname: Abla
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi ,Xinjiang, China.
authors.forename: Erpan
authors.initials: E
authors.lastname: Muhtar
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi ,Xinjiang, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi ,Xinjiang, China.
authors.forename: Murat
authors.initials: M
authors.lastname: Mahmut
mesh_terms: D000328:Adult; D002129:Calcium Oxalate / Q000032:analysis; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000235:genetics*; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D002129:Calcium Oxalate; D005966:Glucuronidase; D000090265:Klotho Proteins