title: Guilt by Association: A Phenotype-Based View of the Plant Phosphoinositide Network.
abstract: Eukaryotic membranes contain small amounts of phospholipids that have regulatory effects on the physiological functions of cells, tissues, and organs. Phosphoinositides (PIs)-the phosphorylated derivatives of phosphatidylinositol-are one example of such regulatory lipids. Although PIs were described in plants decades ago, their contribution to the regulation of physiological processes in plants is not well understood. In the past few years, evidence has emerged that PIs are essential for plant function and development. Recently reported phenotypes associated with the perturbation of different PIs suggest that some subgroups of PIs influence specific processes. Although the molecular targets of PI-dependent regulation in plants are largely unknown, the effects of perturbed PI metabolism can be used to propose regulatory modules that involve particular downstream targets of PI regulation. This review summarizes phenotypes associated with the perturbation of the plant PI network to categorize functions and suggest possible downstream targets of plant PI regulation.
authors.affiliation: Department of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany; email: katharina.gerth@biochemtech.uni-halle.de , feng.lin@biochemtech.uni-halle.de , wilhelm.menzel@biochemtech.uni-halle.de , praveen.krishnamoorthy@biochemtech.uni-halle.de , irene.stenzel@biochemtech.uni-halle.de , mareike.heilmann@biochemtech.uni-halle.de , ingo.heilmann@biochemtech.uni-halle.de.
authors.forename: Katharina
authors.initials: K
authors.lastname: Gerth
authors.affiliation: Department of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany; email: katharina.gerth@biochemtech.uni-halle.de , feng.lin@biochemtech.uni-halle.de , wilhelm.menzel@biochemtech.uni-halle.de , praveen.krishnamoorthy@biochemtech.uni-halle.de , irene.stenzel@biochemtech.uni-halle.de , mareike.heilmann@biochemtech.uni-halle.de , ingo.heilmann@biochemtech.uni-halle.de.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.affiliation: Department of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany; email: katharina.gerth@biochemtech.uni-halle.de , feng.lin@biochemtech.uni-halle.de , wilhelm.menzel@biochemtech.uni-halle.de , praveen.krishnamoorthy@biochemtech.uni-halle.de , irene.stenzel@biochemtech.uni-halle.de , mareike.heilmann@biochemtech.uni-halle.de , ingo.heilmann@biochemtech.uni-halle.de.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Menzel
authors.affiliation: Department of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany; email: katharina.gerth@biochemtech.uni-halle.de , feng.lin@biochemtech.uni-halle.de , wilhelm.menzel@biochemtech.uni-halle.de , praveen.krishnamoorthy@biochemtech.uni-halle.de , irene.stenzel@biochemtech.uni-halle.de , mareike.heilmann@biochemtech.uni-halle.de , ingo.heilmann@biochemtech.uni-halle.de.
authors.forename: Praveen
authors.initials: P
authors.lastname: Krishnamoorthy
authors.affiliation: Department of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany; email: katharina.gerth@biochemtech.uni-halle.de , feng.lin@biochemtech.uni-halle.de , wilhelm.menzel@biochemtech.uni-halle.de , praveen.krishnamoorthy@biochemtech.uni-halle.de , irene.stenzel@biochemtech.uni-halle.de , mareike.heilmann@biochemtech.uni-halle.de , ingo.heilmann@biochemtech.uni-halle.de.
authors.forename: Irene
authors.initials: I
authors.lastname: Stenzel
authors.affiliation: Department of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany; email: katharina.gerth@biochemtech.uni-halle.de , feng.lin@biochemtech.uni-halle.de , wilhelm.menzel@biochemtech.uni-halle.de , praveen.krishnamoorthy@biochemtech.uni-halle.de , irene.stenzel@biochemtech.uni-halle.de , mareike.heilmann@biochemtech.uni-halle.de , ingo.heilmann@biochemtech.uni-halle.de.
authors.forename: Mareike
authors.initials: M
authors.lastname: Heilmann
authors.affiliation: Department of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany; email: katharina.gerth@biochemtech.uni-halle.de , feng.lin@biochemtech.uni-halle.de , wilhelm.menzel@biochemtech.uni-halle.de , praveen.krishnamoorthy@biochemtech.uni-halle.de , irene.stenzel@biochemtech.uni-halle.de , mareike.heilmann@biochemtech.uni-halle.de , ingo.heilmann@biochemtech.uni-halle.de.
authors.forename: Ingo
authors.initials: I
authors.lastname: Heilmann
mesh_terms: D001692:Biological Transport; D008954:Models, Biological; D010641:Phenotype; D010716:Phosphatidylinositols / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D010944:Plants / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D010716:Phosphatidylinositols; D010940:Plant Proteins
keywords: membrane lipids; phenotype-based annotation; phosphoinositides; physiological function; subcellular distribution