title: Role of selectins and their ligands in human implantation stage.
abstract: Selectins are a family of calcium-dependent, type I transmembrane, carbohydrate-binding glycoproteins. Selectins and their ligands are not only involved in physiological processes such as leukocyte homing and pathological processes such as cancer, but also play an essential role in the human implantation. L-selectin and its ligands participate in the adhesion of the blastocyst to the endometrium at the maternal-fetal interface. P-selectin and E-selectin are involved in immune recognition of maternal decidua to the embedded embryo as well as trophoblast migration within decidual spiral arterioles. Moreover, altered expression of selectins and their ligands are found to be associated with some abnormal pregnancies and infertilities. This review focuses on the current progress of research on the role of selectins and their ligands in the human implantation process.
authors.affiliation: Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.|West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Pediatric Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Biology, San Diego State University, San Diego, CA 92182, USA.
authors.forename: Liwen
authors.initials: L
authors.lastname: Deng
authors.affiliation: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77225, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Yao
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan610041, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan610041, P.R. China.
authors.forename: Yilun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan610041, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan610041, P.R. China.
authors.forename: Qianhong
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.|Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ma
mesh_terms: D003656:Decidua / Q000254:growth & development / Q000378:metabolism; D010064:Embryo Implantation / Q000235:genetics*; D004717:Endometrium / Q000254:growth & development / Q000378:metabolism; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D011247:Pregnancy; D019087:Selectins / Q000235:genetics / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism*
chemical_list: D008024:Ligands; D019087:Selectins
keywords: decidua; endometrium; selectin ligands; selectins; trophoblast