title: Correlation between serum S100β protein levels and cognitive dysfunction in patients with cerebral small vessel disease: a case-control study.
abstract: The present study was designed to explore the correlation between serum S100β levels and cognitive dysfunction in patients with cerebral small vessel disease (SVD). A total of 172 SVD patients participated in the study, and they were assigned to patients with no cognitive impairment (NCI group) and those with vascular cognitive impairment no dementia (VCIND group). In total, 105 people were recruited into the normal control group. Serum S100β protein level was detected by ELISA. A receiver operating characteristic (ROC) curve was employed for the predictive value of serum S100β in diagnosing SVD with cognitive dysfunction. Pearson correlation analysis was used to examine the association of S100β level with mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) and the association of S100β levels with hypertension. Logistic regression analysis was used to analyze risk factors of SVD. The serum S100β levels in the VCIND group were higher than those in the NCI and normal control groups. Logistic regression analysis revealed that a high serum S100β protein level, hypertension, and high low density lipoprotein-cholesterol (LDL-C) level were the independent risk factors for SVD. In addition, hypertension patients showed higher S100β levels than those with normal blood pressure and the normal control group, and there was a positive correlation between S100β level and blood pressure. The concentration of serum S100β level was related to impairment of cognition function of VCIND patients, therefore, early detection of serum S100β was of great value for diagnosis of SVD.
authors.affiliation: Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, P.R. China.
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Zou
authors.affiliation: Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P.R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P.R. China.
authors.forename: Xun
authors.initials: X
authors.lastname: Chen
authors.affiliation: Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P.R. China DRyuhualin@163.com tao_sunn@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.affiliation: Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P.R. China DRyuhualin@163.com tao_sunn@163.com.
authors.forename: Hua-Lin
authors.initials: HL
authors.lastname: Yu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D059345:Cerebral Small Vessel Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008078:Cholesterol, LDL / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012372:ROC Curve; D012307:Risk Factors; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: D008078:Cholesterol, LDL; D064568:S100 Calcium Binding Protein beta Subunit
keywords: Cerebral small vessel disease; Cognitive dysfunction; Mini-mental state examination; Montreal cognitive assessment; Serum S100β