title: Congenital malformations according to etiology in newborns from the floricultural zone of Mexico state.
abstract: Birth defects are the number one cause of child mortality worldwide and in 2010 it was the second cause in Mexico. Congenital malformations are a public health issue, because they cause infant mortality, chronic disease and disability. The origin can be genetic, environmental or unknown causes. Among environmental contaminants, pesticides stand out. In this study, we determine the frequency and etiology of congenital malformations in newborns (NBs) of a floricultural community and we compare it with that in the urban community. For 18 months, the NBs were monitored at the Tenancingo General Hospital and the Mother and Child Gynecology and Obstetrics Hospital (IMIEM) in Toluca. The identification of these malformations was carried out in accordance with the WHO. In Tenancingo, 1149 NBs were viewed, where 20% had some kind of congenital malformations. While in the IMIEM, 5069 were reviewed and 6% had some malformation. According to the etiology, in Tenancingo, 69% were multifactorial, 28% were monogenetic and 2% were chromosomal. In the IMIEM, 47% were multifactorial, then 18.3% were monogenetic and 2.8% were chromosomal. There was a significant difference between the global frequency of malformations and the multifactorial etiology of both institutions. Our results show that congenital malformations in the NBs occurred more frequently in the floricultural zone and that because the percentage of multifactorial etiology is higher, it is likely there is an association with exposure to pesticides.
authors.affiliation: Centro de Investigación en Ciencias Médicas, Universidad Autónoma del Estado de México, Jesús Carranza No.205, Col. Universidad, C.P. 50130, Toluca de Lerdo, Mexico. jcastilloc@uaemex.mx.
authors.forename: Julieta
authors.initials: J
authors.lastname: Castillo-Cadena
authors.affiliation: Centro de Investigación en Ciencias Médicas, Universidad Autónoma del Estado de México, Jesús Carranza No.205, Col. Universidad, C.P. 50130, Toluca de Lerdo, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Mejia-Sanchez
authors.affiliation: Centro de Investigación en Ciencias Médicas, Universidad Autónoma del Estado de México, Jesús Carranza No.205, Col. Universidad, C.P. 50130, Toluca de Lerdo, Mexico.
authors.forename: Jerónimo Amado
authors.initials: JA
authors.lastname: López-Arriaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000383:Agriculture; D002947:Cities / Q000453:epidemiology; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology*; D004785:Environmental Pollutants; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010575:Pesticides; D011247:Pregnancy; D012424:Rural Population; D014505:Urban Population; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D010575:Pesticides
keywords: Congenital malformations; Etiology; Floriculture; Pesticides; Workplace exposure