title: [Analysis of Oxaliplatin Combination Therapy for Unresectable or Recurrent Gastric Cancer].
abstract: We analyzed 26 cases of unresectable or recurrent gastric cancer treated with oxaliplatin(OX)combination therapy between September 2014 and January 2016. The number of unresectable gastric cancer cases was 14 and there were 12 recurrent cases. The number of patients receiving S-1 plus OX(SOX), SOX plus trastuzumab(Tmab), capecitabine(Cape)plus OX(CapeOX), and CapeOX plus Tmab was 17, 1, 6, and 2, respectively. The starting dose of OX was 130mg/m2 in 12 patients and 100mg/m2 in 14. The median follow-up duration from the first treatment was 6 months(1-14). The median number of treatment cycles was 5(1-19). Dose reductions occurred in 14 cases, and treatment delay occurred in 13 cases. Grade 3 adverse events occurred in 2 cases(8%); thrombocytopenia and stomatitis occurred in 1 case. The response rate was 23%, the disease control rate was 69%, and the median relapse-free survival time was 4 months(1-14). OX combination therapy for unresectable or recurrent gastric cancer was feasible in terms of safety and might be effective for disease control.
authors.affiliation: Dept. of Surgery, Hokkaido P. W. F. A. C. Sapporo-Kosei General Hospital.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shusaku
authors.initials: S
authors.lastname: Takahashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kenno
authors.forename: Keita
authors.initials: K
authors.lastname: Noguchi
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kakisaka
authors.forename: Munenori
authors.initials: M
authors.lastname: Tahara
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamagami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishizu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D000077150:Oxaliplatin; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin