title: Regulation of Calcium Homeostasis by ER Redox: A Close-Up of the ER/Mitochondria Connection.
abstract: Calcium signaling plays an important role in cell survival by influencing mitochondria-related processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the main storage compartment for cell calcium (Ca2+; ~60-500μM), and the Ca2+released by the ER has a prompt effect on the homeostasis of the juxtaposed mitochondria. Recent findings have highlighted a close connection between ER redox and Ca2+signaling that is mediated by Ca2+-handling proteins. This paper describes the redox-regulated mediators and mechanisms that orchestrate Ca2+signals from the ER to mitochondria.
authors.affiliation: Dulbecco Telethon Institute at IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Chernorudskiy
authors.affiliation: Dulbecco Telethon Institute at IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy. Electronic address: ester.zito@marionegri.it.
authors.forename: Ester
authors.initials: E
authors.lastname: Zito
mesh_terms: D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D008958:Models, Molecular; D010084:Oxidation-Reduction; D021381:Protein Transport; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism; D050994:Voltage-Dependent Anion Channels / Q000235:genetics / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D019837:Ryanodine Receptor Calcium Release Channel; D050994:Voltage-Dependent Anion Channels; D002118:Calcium
keywords: IP3R; RyR; SERCA; mitochondria-associated membranes; redox-regulated calcium signaling