title: [Treatment of asthenoneurotic disorders in children].
abstract: OBJECTIVE
  To evaluate the efficacy of cogitum in the treatment of asthenoneurotic disorders in children after bacterial meningitis (BM) or brain injury (BI).
  
  
  METHODS
  Twenty-four patients were examined. Group 1 included 14 patients with BM, 8 boys and 6 girls, aged 7 - 12 years, mean age 9,91 ± 1,71 years; group 2 consisted of 10 patients with BI, 6 boys and 4 girls, aged 7-12 years, mean age 10,4 ± 2,36 years. All patients received cogitum in dose of 250- 500 mg daily during 8 weeks. Neurological and neuropsychological (Bourdon's test, Luria's tests) examinations, EEG, MRI were performed before and after treatment.
  
  
  CONCLUSIONS
  The study of cognitive functions showed a decrease in the accuracy and speed during performance of Bourdon's and Luria's tests. After the beginning of treatment with cogitum, 80% of the patients in both groups demonstrated a significant improvement in the accuracy of Bourdon's test (р<0,01) and verbal retention (р<0,001). Repeated EEG (3-6 months after treatment) showed the distinct theta- , alpha-, beta- rhythms and clear zonal differences. Given a spectrum of clinical effects of cogitum, the authors recommend it for active use in pediatric practice.
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia; Z.A.Bashlaeva Children's City Clinical Hospital, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Milovanova
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Astanina
mesh_terms: D000368:Aged; D001247:Asthenia / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications*; D009497:Neurotic Disorders / Q000188:drug therapy* / Q000209:etiology; D013386:Succinates / Q000627:therapeutic use
chemical_list: D013386:Succinates