title: Understanding the role of structural integrity and differential expression of integrin profiling to identify potential therapeutic targets in breast cancer.
abstract: Breast cancer is found to be the most prevalent neoplasm in women worldwide. Despite the function of physically tethering cells to the matrix, transmembrane protein integrins are crucially involved in diverse cellular functions such as cell differentiation, proliferation, invasion, migration, and metastasis. Dysregulation of integrins and their interactions with the cells and their microenvironment can trigger several signaling cues that determine the cell fate decision. In this review, we spotlight all pre-existing integrin molecules, their structure, molecular interactions motifs, and function through several cross talks with kinase receptors. We also discuss the role of these integrins as potential prognostic and therapeutic targets and also in the regulation of breast cancer cells differentiation. Understanding of integrin structure and their motifs for ligand interactions in this context will enable the development of new therapeutic approaches to sensitize the tumors and their microenvironment to conventional therapy and overall suppress their metastatic phenotype.
authors.affiliation: Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Das
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India.
authors.forename: Gazal
authors.initials: G
authors.lastname: Kalyan
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand, India.|Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
authors.forename: Saugata
authors.initials: S
authors.lastname: Hazra
authors.affiliation: Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, India.
authors.forename: Mintu
authors.initials: M
authors.lastname: Pal
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D055808:Drug Discovery / Q000379:methods*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015394:Molecular Structure; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D016023:Integrins
keywords: breast cancer; cross-talk signaling; integrins structure; metastasis; prognostic and therapeutic targets