title: Minimizing Skin Scarring through Biomaterial Design.
abstract: Wound healing continues to be a major burden to patients, though research in the field has expanded significantly. Due to an aging population and increasing comorbid conditions, the cost of chronic wounds is expected to increase for patients and the U.S. healthcare system alike. With this knowledge, the number of engineered products to facilitate wound healing has also increased dramatically, with some already in clinical use. In this review, the major biomaterials used to facilitate skin wound healing will be examined, with particular attention allocated to the science behind their development. Experimental therapies will also be evaluated.
authors.affiliation: Division of General and Gastrointestinal Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA. amoore4@stanford.edu.|Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. amoore4@stanford.edu.
authors.forename: Alessandra L
authors.initials: AL
authors.lastname: Moore
authors.affiliation: Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. cmarshal@stanford.edu.
authors.forename: Clement D
authors.initials: CD
authors.lastname: Marshall
authors.affiliation: Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. longaker@stanford.edu.|Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. longaker@stanford.edu.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Longaker
keywords: biomaterials; scar; tissue engineering; wound healing