title: Biocompatible bacterial cellulose membrane in dural defect repair of rat.
abstract: Duraplasty is necessary in nearly 30% of all neurological surgeries. Different tissues and materials have been evaluated in dura mater repair or as dural substitutes in neurosurgery. The aim was to evaluate the biocompatibility of the bacterial cellulose (BC) membranes, produced from sugarcane molasses, for dural defect repair in rats. Forty adults males Wistar rats divided into two groups: a control (ePTFE) and an experimental (BC). Bilateral frontoparietal craniectomy was performed, and a dural defect was created. The arachnoid underlying defect was disrupted with a narrow hook. The animals were observed for 120 days. There were no cases of infection, cerebrospinal fluid fistulae, delayed hemorrhages, behavior disturbances, seizures and palsies. The BC membrane showed to have suitable biocompatibility properties, was not induced immune reaction, nor chronic inflammatory response and absence of neurotoxicity signals.
authors.affiliation: Center for Experimental Surgery, Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil.
authors.forename: Frederico de Melo Tavares de
authors.initials: FM
authors.lastname: Lima
authors.affiliation: Center for Experimental Surgery, Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil. fcmorone@gmail.com.
authors.forename: Flávia Cristina Morone
authors.initials: FC
authors.lastname: Pinto
authors.affiliation: Department of Physiology and Pharmacology, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Belmira Lara da Silveira
authors.initials: BL
authors.lastname: Andrade-da-Costa
authors.affiliation: Immunopathology Laboratory Keizo Asami, LIKA, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil.
authors.forename: Jaiurte Gomes Martins da
authors.initials: JG
authors.lastname: Silva
authors.affiliation: Immunopathology Laboratory Keizo Asami, LIKA, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil.
authors.forename: Olávio
authors.initials: O
authors.lastname: Campos Júnior
authors.affiliation: Center for Experimental Surgery, Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil.
authors.forename: José Lamartine de Andrade
authors.initials: JL
authors.lastname: Aguiar
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D004388:Dura Mater / Q000187:drug effects* / Q000293:injuries; D007107:Immune System; D007249:Inflammation; D008297:Male; D008965:Molasses; D051381:Rats; D017208:Rats, Wistar; D031786:Saccharum; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D002482:Cellulose