title: Hepatoprotective standardized EtOH-water extract of the leaves of Ziziphus jujuba.
abstract: The hepatoprotective activity of the EtOH-water extract of Ziziphus jujuba leaves was evaluated against CCl4-induced hepatic damage in mice. The EtOH-water extract significantly alleviated liver damage as indicated by the decreased levels of serum ALT and AST and the decreased MDA content, the increased levels of SOD, GSH and GSH-Px, and the reduced pathological tissue injury induced by CCl4. A quantitative analysis of fifteen major constituents (1-15) of the EtOH-water extract of the leaves of Z. jujuba was conducted by HPLC-DAD. Based on our research results, it can be concluded that the EtOH-water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of CCl4-induced hepatic injury in mice. Flavonoids might be the active ingredients responsible for the biological and pharmacological activities towards hepatoprotection.
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Lu
authors.initials: L
authors.lastname: Bai
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Cui
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Ni
authors.initials: N
authors.lastname: Cheng
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Sen
authors.initials: S
authors.lastname: Guo
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901, USA.
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
authors.affiliation: College of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, China 710069. nsbai@nwu.edu.cn.
authors.forename: Naisheng
authors.identifier: http://orcid.org/0000-0001-6056-9192
authors.initials: N
authors.lastname: Bai
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D002251:Carbon Tetrachloride