title: Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells. Retracted
abstract: The purpose of this study was to investigate the effect of the heparanase inhibitor OGT2115 on the tumorigenic properties of KB oral cancer cells.
  
  
  
  We treated KB cells with different concentrations of OGT2115. Then proliferation, invasion, and migration were detected using different assays. Cell cycle was explored using flow cytometry.
  
  
  
  We found that the treatment inhibited proliferation, invasion, and migration in a dose-dependent manner. OGT2115 also increased the apoptosis of KB cells and blocked cell cycle in S-phase.
  
  
  
  Our results support the use of the heparanase inhibitor OGT2115 to inhibit several tumorigenic activities of KB oral cancer cells.
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, China. sx9l58@163.com.
authors.forename: S
authors.initials: S
authors.lastname: Shen
authors.forename: J-X
authors.initials: JX
authors.lastname: Tang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005966:Glucuronidase / Q000037:antagonists & inhibitors*; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D009361:Neoplasm Invasiveness; D000099175:Heparanase
chemical_list: D004791:Enzyme Inhibitors; D005966:Glucuronidase; D000099175:Heparanase