title: A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring.
abstract: A new way of developing novel synthesis strategies for the construction of monocyclic rings found in organic molecules is presented. The method is based on the visual application of integer partitioning to chemical structures. Two problems are addressed: (1) the determination of the total number of possible ways to construct a given ring by 2-, 3-, and 4-component couplings; and (2) the systematic enumeration of those possibilities. The results of the method are illustrated using cyclohexanone, pyrazole, and the Biginelli adduct as target ring systems with a view to discover new and greener strategies for their construction using multicomponent reactions. The application of the method is also extended to various heterocycles found in many natural products and pharmaceuticals.
authors.affiliation: CareerChem, 504-1129 Don Mills Road, Toronto, ON M3B 2W4 Canada.
authors.forename: John
authors.initials: J
authors.lastname: Andraos
keywords: atom economy; green organic synthesis; integer partitioning; probability; reactions; retrosynthetic analysis; ring construction strategy