title: An efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives under catalyst-free conditions.
abstract: A concise, efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives via a three-component reaction of 4-oxo-4H-chromene-3-carbaldehydes, malononitrile or cyanoacetates, and aromatic amines under catalyst-free conditions in an environmentally friendly medium (ethanol-water, 3:1 v/v) is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Yong-Xiang
authors.initials: YX
authors.lastname: Zheng
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Xun
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Huang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China. dqshi@suda.edu.cn.
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Shi
mesh_terms: D060326:Chemistry Techniques, Synthetic; D000431:Ethanol / Q000737:chemistry; D055772:Green Chemistry Technology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D011725:Pyridines; D014867:Water; D000431:Ethanol
keywords: Chromeno[4,3-b]pyridine; Group-assisted purification (GAP) process; Multicomponent reactions (MCRs)