title: Gender differences in risk profile and outcome of Middle Eastern patients undergoing percutaneous coronary intervention.
abstract: To determine the gender differences in cardiovascular risk profile and outcomes among patients undergoing percutaneous coronary intervention (PCI). Methods: In a prospective multicenter study of consecutive Middle Eastern patients managed with PCI from January 2013 to February 2014 in 12 tertiary care centers in Amman and Irbid, Jordan. Clinical and coronary angiographic features, and major cardiovascular events were assessed for both genders from hospital stay to 1 year. Results: Women comprised 20.6% of 2426 enrolled patients, were older (mean age 62.9 years versus 57.2 years), had higher prevalence of hypertension (81% versus 57%), diabetes (66% versus 44%), dyslipidemia (58% versus 46%), and obesity (44% versus 25%) compared with men, p less than 0.001. The PCI for ST-segment elevation myocardial infarction was indicated for fewer women than men (23% versus 33%; p=0.001). Prevalence of single or multi-vessel coronary artery disease was similar in women and men. More women than men had major bleeding during hospitalization (2.2% versus 0.6%; p=0.003) and at one year (2.5% versus 0.9%; p=0.007). There were no significant differences between women and men in mortality (3.1% versus 1.7%) or stent thrombosis (2.1% versus 1.8%) at 1 year. Conclusion: Middle Eastern women undergoing PCI had worse baseline risk profile compared with men.Except for major bleeding, no gender differences in the incidence of major adverse cardiovascular events were demonstrated.
authors.affiliation: Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordon. E-mail. mijarrah@just.edu.jo.
authors.forename: Mohamad I
authors.initials: MI
authors.lastname: Jarrah
authors.forename: Ayman J
authors.initials: AJ
authors.lastname: Hammoudeh
authors.forename: Dalal B
authors.initials: DB
authors.lastname: Al-Natour
authors.forename: Yousef S
authors.initials: YS
authors.lastname: Khader
authors.forename: Ramzi A
authors.initials: RA
authors.lastname: Tabbalat
authors.forename: Imad A
authors.initials: IA
authors.lastname: Alhaddad
authors.forename: Susan M
authors.initials: SM
authors.lastname: Kullab
mesh_terms: D017023:Coronary Angiography / Q000706:statistics & numerical data; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008877:Middle East / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000706:statistics & numerical data*; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D016896:Treatment Outcome