title: Protective Effect of Green Tea (Camellia sinensis(L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients.
abstract: Green tea (GT) has been studied for its effects as antioxidant and cancer-preventive agent. Epidemiological studies showed that GT consumption decreases the risk for prostate cancer (PC). To investigate whether erythrocyte oxidative stress (OS) is associated with PC and whether daily consumption of GT improves the oxidative phenotype, we performed a study in a group of Algerian PC patients, preceded by an in vitro study to characterize composition and antioxidant/antiproliferative activities of the GT used. This contained a high content of phenolic and flavonoid compounds, demonstrating in vitro antioxidant activity and significant antiproliferative effect on human prostate cancer PC-3 cell line. Seventy PC patients and 120 age-matched healthy subjects participated in the study, with glutathione (GSH), malondialdehyde (MDA), and catalase activity evaluated before and after GT consumption. The results showed a reduced GSH and catalase activity and a high level of MDA in erythrocytes from PC patients. The consumption of 2-3 cups per day of GT during 6 months significantly increased GSH concentration and catalase activity and decreased MDA concentration. In conclusion, GT significantly decreased OS in Algerian PC patients. Regular consumption of GT for a long period may prevent men from developing PC or at least delay its progression.
authors.affiliation: Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria; Laboratoire de Physiologie Animale, Département de Biologie Animale, Faculté des Sciences de la Nature et de la Vie, Université Constantine 1, 25000 Constantine, Algeria; Clinic of Urology-Nephrology and Kidney Transplant Daksi, Constantine, Algeria.
authors.forename: Somia
authors.initials: S
authors.lastname: Lassed
authors.affiliation: CNC-Center for Neuroscience and Cellular Biology, UC-Biotech Building, Biocant Park, University of Coimbra, Coimbra, Portugal.
authors.forename: Cláudia M
authors.initials: CM
authors.lastname: Deus
authors.affiliation: Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria; Laboratoire de Physiologie Animale, Département de Biologie Animale, Faculté des Sciences de la Nature et de la Vie, Université Constantine 1, 25000 Constantine, Algeria.
authors.forename: Radja
authors.initials: R
authors.lastname: Djebbari
authors.affiliation: Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria.
authors.forename: Djamila
authors.identifier: 0000-0002-4312-7701
authors.initials: D
authors.lastname: Zama
authors.affiliation: CNC-Center for Neuroscience and Cellular Biology, UC-Biotech Building, Biocant Park, University of Coimbra, Coimbra, Portugal.
authors.forename: Paulo J
authors.identifier: 0000-0002-5201-9948
authors.initials: PJ
authors.lastname: Oliveira
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
authors.forename: Albert A
authors.identifier: 0000-0002-9427-5739
authors.initials: AA
authors.lastname: Rizvanov
authors.affiliation: Clinic of Urology-Nephrology and Kidney Transplant Daksi, Constantine, Algeria.
authors.forename: Abderrezak
authors.initials: A
authors.lastname: Dahdouh
authors.affiliation: Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria.
authors.forename: Fadila
authors.initials: F
authors.lastname: Benayache
authors.affiliation: Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria.
authors.forename: Samir
authors.initials: S
authors.lastname: Benayache