title: Recent progression in the utilization of autophagy-regulating nature compound as anti-liver fibrosis agents.
abstract: Hepatic fibrosis is a wound-healing response to chronic liver injury caused by various pathogenesis, such as hepatitis virus infection, drugs toxicity and autoimmune imbalances. Autophagy, a cellular process degrading damaged organelles or aggregative proteins, participates in multiple human diseases including hepatic fibrosis. However, the precise role of autophagy in the pathogenesis of hepatic fibrosis is yet to be elucidated. Accumulated evidences indicate that several nature compounds exhibit anti-fibrotic potential through modulating autophagy activity. For a better understanding of the relationships among autophagy, hepatic fibrosis, and autophagy-regulating nature compounds, this review highlights the recent advancement of nature compounds treating hepatic fibrosis through regulating autophagy.
authors.affiliation: a Key Laboratory of Biotechnology of Antibiotics of NHFPC , Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors.forename: Mao-Xu
authors.initials: MX
authors.lastname: Ge
authors.affiliation: a Key Laboratory of Biotechnology of Antibiotics of NHFPC , Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: He
authors.affiliation: a Key Laboratory of Biotechnology of Antibiotics of NHFPC , Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors.forename: Rong-Guang
authors.initials: RG
authors.lastname: Shao
authors.affiliation: a Key Laboratory of Biotechnology of Antibiotics of NHFPC , Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000188:drug therapy*; D015394:Molecular Structure; D015398:Signal Transduction
keywords: Hepatic fibrosis; autophagy; natural compounds