title: Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs.
abstract: Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P< 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P< 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P< 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression.
authors.affiliation: Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Universidad de la República, Lasplaces 1550, Montevideo, Uruguay.
authors.forename: P
authors.initials: P
authors.lastname: Pessina
authors.affiliation: Cat. Clin. Méd. Peq. An. and U. Endocrinología, Escuela Medicina Veterinaria, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires. Av. Chorroarín 280, C. Autónoma de Buenos Aires, Argentina.
authors.forename: V A
authors.initials: VA
authors.lastname: Castillo
authors.affiliation: Instituto Plan Agropecuario, Br. Artigas 3802, Montevideo, Uruguay.
authors.forename: D
authors.initials: D
authors.lastname: César
authors.affiliation: Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Universidad de la República, Lasplaces 1550, Montevideo, Uruguay.
authors.forename: I
authors.initials: I
authors.lastname: Sartore
authors.affiliation: Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Universidad de la República, Lasplaces 1550, Montevideo, Uruguay.
authors.forename: A
authors.initials: A
authors.lastname: Meikle
keywords: Canine; Histology; Immunohistochemistry; Thyroid carcinoma