title: Aggressive Early Debridement in Treatment of Acute Periprosthetic Joint Infections After Hip and Knee Replacements.
abstract: BACKGROUND
  Periprosthetic Joint Infection Remains a Dreaded Complication After Hip and Knee Replacement Surgery. Treatment Options for Acute Postoperative and Acute Hematogenous Infections Include Arthroscopic or Open Debridement With Retention or Exchange of the Prostheses. This Review Article Aims to Summarize the Evidence for Management of Acute Postoperative And Acute Hematogenous Infections.
  
  
  METHODS
  A Systematic Literature Search Was Performed Using a Computer-based Search Engine Covering Medline (OvidSP), PubMed Database (U.S. National Library of Medicine, National Institutes of Health), Embase, Web of Science, Cochrane and Google Scholar for Relevant Articles.
  
  
  RESULTS
  Common Themes Around Treatment of Acute Postoperative and Acute Hematogenous Infections Discussed in this Review Include the Timing of Intervention, Description of the Optimal Procedure and How we Perform it at our Institution, the Role of Arthroscopic Debridement, Most Commonly Isolated Micro-organisms and Prognostic Factors for Infection Control.
  
  
  CONCLUSIONS
  Success in Treating Acute Postoperative and Acute Hematogenous Infections Depends on Early Diagnosis and Aggressive Surgical Debridement Combined With Effective Antibiotic Therapy.
authors.affiliation: Department of Trauma and Orthopaedics, University College London Hospital, 235 Euston Road, NW1 2BU, London, United Kingdom.
authors.forename: Andrea
authors.initials: A
authors.lastname: Volpin
authors.affiliation: Department of Trauma and Orthopaedics, The Royal London Hospital, Whitechapel, E1 1BB, London, United Kingdom.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sukeik
authors.affiliation: Department of Trauma and Orthopaedics, The Royal London Hospital, Whitechapel, E1 1BB, London, United Kingdom.
authors.forename: Sulaiman
authors.initials: S
authors.lastname: Alazzawi
authors.affiliation: Department of Trauma and Orthopaedics, University College London Hospital, 235 Euston Road, NW1 2BU, London, United Kingdom.
authors.forename: Fares Sami
authors.initials: FS
authors.lastname: Haddad
keywords: Acute; Arthroplasty; Debridement; Hip; Irrigation; Knee; Periprosthetic joint infection