title: CPEB4 links the clock and the UPR to protect the liver.
abstract: Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.
authors.affiliation: Department of Pathology, Diabetes Center, and Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, California 94143, USA.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Moore
authors.affiliation: Department of Pathology, Diabetes Center, and Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, California 94143, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Oakes
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008099:Liver / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D056811:Unfolded Protein Response / Q000502:physiology*
chemical_list: C554939:CPEB4 protein, human; D016601:RNA-Binding Proteins