title: [Molecular mechanisms of pidolate magnesium action and its neurotropic affects].
abstract: OBJECTIVE
  A complex study of pharmacological properties of magnesium pyroglutamate using the modern methods of chemoinformatics and bioinformatics.
  
  
  METHODS
  Pharmacological properties of magnesium pyroglutamate were studied using chemoinformatic and bioinformatic analyses.
  
  
  RESULTS
  Neurotropic effects of magnesium pyroglutamate are due to an influence on the synthesis of neuropeptides containing pyroglutamate (orexin, thyroliberin, neurotensin etc) and due to the similarity between pyroglutamate-anion with some neuroactive components (L-theanine, 2-pirrolydinone, piracetam).
  
  
  CONCLUSIONS
  The results of the study suggest neuroprotective, sedative and antidepressive properties of magnesium pyroglutamate which are realized by pyroglutamate-anion in the synergism with magnesium cation.
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Gromova
authors.affiliation: Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Torshin
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kalacheva
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia.
authors.forename: L E
authors.initials: LE
authors.lastname: Fedotova
authors.affiliation: Ivanovo State Medical Academy, Ivanovo, Russia, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Rudakov
mesh_terms: D000818:Animals; D000928:Antidepressive Agents; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D048088:Informatics / Q000379:methods; D009479:Neuropeptides / Q000096:biosynthesis*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives; D009479:Neuropeptides; D018696:Neuroprotective Agents; D011761:Pyrrolidonecarboxylic Acid