title: Areas of research and clinical approaches to the study of liver abscess.
abstract: OBJECTIVE
  To analyze the research activity on liver abscess (LA) and identify the main topic clusters in the area.
  
  
  METHODS
  We identified all documents using the medical subject heading "LA" indexed in the MEDLINE database between 2001 and 2015. We performed a descriptive bibliometric analysis, characterizing the evolution of scientific activity, the publication types of the documents, the document categories of clinical interest (case reports, clinical trials, evaluation studies, meta-analysis, observational studies, practice guidelines and validation studies) and the geographic distribution of the research. We also carried out an analysis of networks and research clusters in order to identify the main topic areas of research.
  
  
  RESULTS
  Our search yielded a total of 1278 documents, showing a stable scientific production over the study period and a marked multidisciplinary nature. The research was dominated by case reports (65.9% of the documents analyzed). In terms of geographic distribution, researchers from the United States led in the number of signatures (n= 229), followed by those from Taiwan (n= 185), India (n= 145), Japan (n= 144), South Korea (n= 100), and China (n= 84). With regard to amebic LA, the top-producing countries were India and Mexico (n= 69 each), followed by the United States (n= 29). In the case of pyogenic LA, Taiwanese researchers led scientific production (n= 71), followed by the United States (n= 39) and China (n= 29). The most active areas of research in the field are diagnosisviacomputerized tomography scan, differential diagnosis with regard to liver cancer, treatment with antimicrobial agents, andKlebsiellainfections (including bacteremia).
  
  
  CONCLUSIONS
  Clinical case reports associated with diagnosis and treatment are the main topic of study, highlighting the importance of this document type in advancing knowledge.
authors.affiliation: Gregorio González-Alcaide, Department of History of Science and Documentation, University of Valencia, 46010 Valencia, Spain.
authors.forename: Gregorio
authors.initials: G
authors.lastname: González-Alcaide
authors.affiliation: Gregorio González-Alcaide, Department of History of Science and Documentation, University of Valencia, 46010 Valencia, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Peris
authors.affiliation: Gregorio González-Alcaide, Department of History of Science and Documentation, University of Valencia, 46010 Valencia, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Ramos
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D015706:Bibliometrics; D035843:Biomedical Research; D002681:China; D003937:Diagnosis, Differential; D004748:Entamoeba histolytica; D006801:Humans; D015994:Incidence; D007194:India; D007564:Japan; D007710:Klebsiella Infections / Q000150:complications; D008100:Liver Abscess / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D008101:Liver Abscess, Amebic / Q000469:parasitology; D046290:Liver Abscess, Pyogenic / Q000382:microbiology; D008113:Liver Neoplasms / Q000175:diagnosis*; D008800:Mexico; D056910:Republic of Korea; D012108:Research Personnel; D013624:Taiwan; D014057:Tomography, X-Ray Computed; D014481:United States
chemical_list: D000890:Anti-Infective Agents
keywords: Amebic abscess; Bibliometrics; Cluster analysis; Liver abscess; Pyogenic abscess