title: Irritability and internalizing symptoms: Modeling the mediating role of emotion regulation.
abstract: Irritability and emotion regulation are both important transdiagnostic factors that contribute to the development of internalizing symptoms during adolescence. The current study examined whether emotion regulation mediates the relationship between irritability and internalizing symptoms.
  
  
  
  To examine this relationship we analysed the indirect effect of irritability (measured using a single item from the Goldberg Mania Questionnaire) on internalizing symptoms (anxiety and depression) via the mediator, emotion regulation (Difficulties in Emotion Regulation Scale) in 112 adolescent females.
  
  
  
  Mediation analysis, using bootstrapping, showed a significant indirect effect and suggests that the relationship between irritability and internalizing symptoms is mediated by emotion dysregulation.
  
  
  
  These include measuring irritability using a single item and employing a cross sectional design.
  
  
  
  These novel findings add to our understanding of the processes and mechanisms by which irritability contributes to the development of internalizing symptoms.
authors.affiliation: Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW 2065 Australia; Sydney Medical School Northern, University of Sydney, NSW 2006, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia. Electronic address: gin.malhi@sydney.edu.au.
authors.forename: Gin S
authors.initials: GS
authors.lastname: Malhi
authors.affiliation: Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW 2065 Australia; Sydney Medical School Northern, University of Sydney, NSW 2006, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia.
authors.forename: Yulisha
authors.initials: Y
authors.lastname: Byrow
authors.affiliation: Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW 2065 Australia; Sydney Medical School Northern, University of Sydney, NSW 2006, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia.
authors.forename: Tim
authors.initials: T
authors.lastname: Outhred
authors.affiliation: Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW 2065 Australia; Sydney Medical School Northern, University of Sydney, NSW 2006, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia.
authors.forename: Pritha
authors.initials: P
authors.lastname: Das
authors.affiliation: Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW 2065 Australia; Sydney Medical School Northern, University of Sydney, NSW 2006, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Fritz
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D001007:Anxiety / Q000523:psychology*; D003430:Cross-Sectional Studies; D003674:Defense Mechanisms; D003863:Depression / Q000523:psychology; D004644:Emotions; D005260:Female; D006801:Humans; D007389:Internal-External Control; D007508:Irritable Mood; D012307:Risk Factors; D011795:Surveys and Questionnaires
keywords: Adolescence; Emotion regulation; Internalizing symptoms; Irritability