title: High-dose anti-histamine use and risk factors in children with urticaria.
abstract: OBJECTIVE
  The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.
  
  
  METHODS
  The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria.
  
  
  RESULTS
  The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p<0.0001). There was no difference between the two groups in terms of blood eosinophil and basophil counts, and serum total IgE levels (p>0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=-0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged ≥10 years (p<0.001, p=0.015). High UAS7 score (OR: 1.09; CI 95%: [1.03-1.15]) and basopenia (OR: 6.77; CI 95%: [2.01-22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria.
  
  
  CONCLUSIONS
  The requirement of high-dose H1-antihistamines was higher with children's increasing age. Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines.
authors.affiliation: Division of Pediatric Allergy and Clinical Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Uysal
authors.affiliation: Department of Child and Adolescent Psychiatry, Adnan Menderes University School of Medicine, Aydın, Turkey.
authors.forename: Sibelnur
authors.initials: S
authors.lastname: Avcil
authors.affiliation: Division of Pediatric Allergy and Clinical Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Erge
keywords: Acute urticaria; antihistamine; chronic urticaria; pediatrics; treatment; urticaria