title: Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma.
abstract: The aim of the study was to analyze the effects of the intravenous infusion of salbutamol aerosol combined with magnesium sulfate in the treatment of pediatric asthma and the subsequent effects on the levels of T-lymphocyte subgroups and Th1/Th2 cytokines. A total of 86 patients with pediatric asthma, first diagnosed and treated at the Xuzhou Children's Hospital, were continuously selected and randomly divided into an observation group of 44 cases and control group of 42 cases. The patients in the control group were treated with budesonide atomization inhalation, while the children in the observation group were treated with intravenous infusion of salbutamol aerosol combined with magnesium sulfate. The therapeutic effects in the groups were compared. After treatment, the levels of serum CD3+and CD8+decreased when compared to before treatment; the levels of CD4+and CD4+/CD8+also increased, but the observation group had more significant improvement. Differences were statistically significant (P<0.05). After treatment, the levels of serum interleukin-2 (IL-2) and interferon-γ (IFN-γ) increased when compared to before, while levels of IL-4 and IL-6 decreased, and the observation group had more significant improvement. The differences were statistically significant (P<0.05). After treatment, the levels of VT, t-PTEF/t-E, MTIF/MTEF and TEF75/PTEF increased when compared to before; the observation group had more significant improvement. The differences were statistically significant (P<0.05). The effective rate and degree of treatment for the observation group were significantly higher than those of the control group and differences were statistically significant (P<0.05). The intravenous infusion of salbutamol aerosol combined with magnesium sulfate in the treatment of pediatric asthma can significantly improve therapeutic effects and lung functions, improve immune functions and relieve inflammatory reactions. Therefore, it indicates better clinical application and promotion value.
authors.affiliation: Department of Respiratory Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Diao
authors.affiliation: Department of Respiratory Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Min
authors.affiliation: Department of Respiratory Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
authors.affiliation: Department of Respiratory Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Chong-Lin
authors.initials: CL
authors.lastname: Zhang
keywords: T lymphocyte subgroup; Th1/Th2 cytokines; magnesium sulfate; pediatric asthma; salbutamol aerosol