title: Effects of Radiation Therapy on Established Neurogenic Heterotopic Ossification.
abstract: Heterotopic ossification (HO) is frequently seen on rehabilitation units after spinal cord injuries, fractures, brain injuries, and limb amputations. Currently, there is no effective treatment for HO other than prophylaxis with anti-inflammatory medications, irradiation, and bisphosphonate administration. These prophylactic treatments are not effective for managing ectopic bone once it has formed. Here we describe three cases of established neurogenic HO treated with radiation therapy (RT). All patients had decreased serum alkaline phosphatase (ALP) and bone-specific ALP levels with decreased pain but increased range of motion immediately after RT. Post-treatment X-rays revealed no further growth of the HO. All patients maintained clinical and laboratory improvements 4 or 6 months after the RT. Our results suggest that RT is safe and effective in decreasing pain and activity of neurogenic HO.
authors.affiliation: Department of Rehabilitation Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
authors.forename: Chan Ho
authors.identifier: 0000-0002-5129-6652
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
authors.forename: Su Jung
authors.identifier: 0000-0002-2364-6651
authors.initials: SJ
authors.lastname: Shim
authors.affiliation: Department of Rehabilitation Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
authors.forename: Hyun Jung
authors.identifier: 0000-0002-2198-5668
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Rehabilitation Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
authors.forename: Hyuna
authors.identifier: 0000-0002-2265-4166
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Rehabilitation Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
authors.forename: Youn Joo
authors.identifier: 0000-0002-9938-5435
authors.initials: YJ
authors.lastname: Kang
keywords: Brain injuries; Heterotopic ossification; Radiotherapy