title: THA and TKA in patients with cardiovascular disease: What makes the risk of perioperative bleeding?
abstract: Backround: The purpose of the study was to ascertain the incidence of bleeding and ischaemic complications in patients with cardiac disease after total hip arthroplasty (THA) and total knee arthroplasty (TKA).
  
  
  
  In total, 477 patients (289 women, 188 men) with known history of cardiac disease or thromboembolic disease treated with surgery in 2010-2013, were enrolled in the study. Perioperative prevention of thromboembolic disease using low-molecular-weight heparins was applied in all the patients. The data that could have an impact on the development of monitored perioperative complications, were observed.
  
  
  
  Complications occurred in 55 (11.6 %) patients: bleeding complications in 32, ischaemic in 19, and both in four patients. Complications were found in 13 (12.0 %) patients after THA and in 6 (9.5 %) patients after TKA. Bleeding complications were observed in 17 patients after THA and TKA, ischaemic in one, and both simultaneously in one patient.Bleeding complications occurred insignificantly more frequently after THA and TKA (p = 0.094); however, this difference was statistically significant after adjustment for risk factors (p = 0.003). On the contrary, ischaemic complications were significantly more frequent after other skeletal surgeries (p = 0.014). Nevertheless, this difference was not statistically significant after the adjustment (p = 0.880). The comparison of the risk of complications in patients after THA with that in patients after TKA showed no significant difference (p = 0.580).
  
  
  
  The study showed a significantly higher incidence of bleeding complications in patients after THA and TKA compared to other surgeries of the musculoskeletal system in patients with a history of cardiac disease. Bleeding complications cannot be detected in advance (Tab. 1, Ref. 16).
authors.forename: V
authors.initials: V
authors.lastname: Dzupa
authors.forename: Z
authors.initials: Z
authors.lastname: Motovska
authors.forename: P
authors.initials: P
authors.lastname: Widimsky
authors.forename: P
authors.initials: P
authors.lastname: Waldauf
authors.forename: M
authors.initials: M
authors.lastname: Ondrakova
authors.forename: R
authors.initials: R
authors.lastname: Bartoska
authors.forename: M
authors.initials: M
authors.lastname: Jezek
authors.forename: T
authors.initials: T
authors.lastname: Lena
authors.forename: O
authors.initials: O
authors.lastname: Popelka
authors.forename: M
authors.initials: M
authors.lastname: Krbec
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000517:prevention & control*; D006493:Heparin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D059035:Perioperative Period; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology*
chemical_list: D000925:Anticoagulants; D006493:Heparin
keywords: ischaemic complications; perioperative bleeding; total hip replacement total knee replacement.