title: [Surgical treatment of achalasia - endoscopic or laparoscopic? : Proposal for a tailored approach].
abstract: Primary idiopathic achalasia is the most common form of the rare esophageal motility disorders. A curative therapy which restores the normal motility does not exist; however, the therapeutic principle of cardiomyotomy according to Ernst Heller leads to excellent symptom control in the majority of cases. The established standard approach is Heller myotomy through the laparoscopic route (LHM), combined with Dor anterior fundoplication for reflux prophylaxis/therapy. At least four meta-analyses of randomized controlled trials (RCTs) have demonstrated superiority of LHM over pneumatic dilation (PD); therefore, LHM should be used as first line therapy (without prior PD) in all operable patients. Peroral endoscopic myotomy (POEM) is a new alternative approach, which enables Heller myotomy to be performed though the endoscopic submucosal route. The POEM procedure has a low complication rate and also leads to good control of dysphagia but reflux rates can possibly be slightly higher (20-30%). Long-term results of POEM are still scarce and the results of the prospective randomized multicenter trial POEM vs. LHM are not yet available; however, POEM seems to be the preferred treatment option for certain indications. Within the framework of the tailored approach for achalasia management of POEM vs. LHM established in Würzburg, we recommend long-segment POEM for patients with type III achalasia (spasmodic) and other hypercontractile motility disorders and potentially type II achalasia (panesophageal compression) with chest pain as the lead symptom, whereas LHM can also be selected for type I. For sigmoid achalasia, especially with siphon-like transformation of the esophagogastric junction, simultaneous hiatal hernia and epiphrenic diverticula, LHM is still the preferred approach. The choice of the procedure for revisional surgery in case of recurrent dysphagia depends on the suspected mechanism (morphological vs. functional/neuromotor).
authors.affiliation: Klinik für Allgemein-, Viszeral, Gefäß- und Kinderchirurgie, Zentrum für operative Medizin (ZOM), Universitätsklinikum Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Deutschland. Rahden_B@ukw.de.
authors.forename: B H A von
authors.initials: BH
authors.lastname: Rahden
authors.affiliation: Klinik für Allgemein-, Viszeral, Gefäß- und Kinderchirurgie, Zentrum für operative Medizin (ZOM), Universitätsklinikum Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Filser
authors.affiliation: Klinik für Allgemein-, Viszeral, Gefäß- und Kinderchirurgie, Zentrum für operative Medizin (ZOM), Universitätsklinikum Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Al-Nasser
authors.affiliation: Klinik für Allgemein-, Viszeral, Gefäß- und Kinderchirurgie, Zentrum für operative Medizin (ZOM), Universitätsklinikum Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Deutschland.
authors.forename: C-T
authors.initials: CT
authors.lastname: Germer
mesh_terms: D002299:Cardia / Q000601:surgery; D004931:Esophageal Achalasia / Q000145:classification / Q000175:diagnosis / Q000601:surgery*; D004945:Esophagoscopy / Q000379:methods*; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000145:classification / Q000175:diagnosis / Q000601:surgery; D019983:Guideline Adherence; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology
keywords: Achalasia; Esophageal motility disorders; Gastroesophageal reflux; Laparoscopic myotomy; Peroral endoscopic myotomy