title: Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography.
abstract: We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system ( > 200 ?? kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United StatesbShandong Normal University, Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, Institute of Biomedical Sciences, School of Physics and Electronics, Jinan, Shandong, China.
authors.forename: Pengxiao
authors.initials: P
authors.lastname: Zang
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.
authors.forename: Gangjun
authors.initials: G
authors.lastname: Liu
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Hwang
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.
authors.forename: David J
authors.initials: DJ
authors.lastname: Wilson
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.affiliation: Shandong Normal University, Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, Institute of Biomedical Sciences, School of Physics and Electronics, Jinan, Shandong, China.
authors.forename: Dengwang
authors.initials: D
authors.lastname: Li
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000465:Algorithms; D000792:Angiography; D003430:Cross-Sectional Studies; D006801:Humans; D012160:Retina / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence