title: Change in Caco-2 cells following treatment with various lavender essential oils.
abstract: Lavender is an aromatic evergreen shrub diffused in the Mediterranean basin appreciated since antiquity. The genus Lavandula is part of Lamiaceae family and includes more than 20 species, among which true lavender (L. vera D.C. or L. angustifolia Miller.) and spike lavender (L. latifolia Medikus); there are also numerous hybrids known as lavandins (L. hybrida Rev.). L. vera, spike lavender and several hybrids are the most intensely used breeding species for the production of essential oils. Lavender and lavandin essential oils have been applied in food, pharmaceutical and other agro industries as biological products. In their chemical composition, terpenes linalool and linalyl acetate along with terpenoids such as 1,8-cineole are mostly responsible for biological and therapeutic activities. This study evaluates cytotoxic activity of essential oils derived from four lavender species on human epithelial colorectal adenocarcinoma cells. Analysis of pre- and post-treatment cell morphology has been performed using scanning electron microscope.
authors.affiliation: a Department of Biomedical Science , University of Sassari , Sassari , Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Donadu
authors.affiliation: a Department of Biomedical Science , University of Sassari , Sassari , Italy.
authors.forename: D
authors.initials: D
authors.lastname: Usai
authors.affiliation: a Department of Biomedical Science , University of Sassari , Sassari , Italy.
authors.forename: V
authors.initials: V
authors.lastname: Mazzarello
authors.affiliation: a Department of Biomedical Science , University of Sassari , Sassari , Italy.
authors.forename: P
authors.initials: P
authors.lastname: Molicotti
authors.affiliation: a Department of Biomedical Science , University of Sassari , Sassari , Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cannas
authors.affiliation: b Department of Agricultural Sciences , University of Bologna , Bologna , Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Bellardi
authors.affiliation: a Department of Biomedical Science , University of Sassari , Sassari , Italy.
authors.forename: S
authors.initials: S
authors.lastname: Zanetti
mesh_terms: D000080462:Acyclic Monoterpenes; D018938:Caco-2 Cells; D003511:Cyclohexanols / Q000032:analysis / Q000494:pharmacology; D000077591:Eucalyptol; D006801:Humans; D027523:Lavandula / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D039821:Monoterpenes / Q000032:analysis / Q000494:pharmacology; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000080462:Acyclic Monoterpenes; D003511:Cyclohexanols; D039821:Monoterpenes; D009822:Oils, Volatile; C074463:linalyl acetate; C018584:linalool; D000077591:Eucalyptol
keywords: Colon cancer; drugs; electron microscopy; essential oils; lavender; morphology