title: A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods.
abstract: Rod-shape nanocarriers have attracted great interest because of their better cell internalization capacity and higher drug loading properties. Besides, the combination of photodynamic therapy (PDT) and photothermal therapy (PTT) holds great promise to overcome respective limitations of the anti-cancer treatment. In this work, we first report Au nanorods-capped and Ce6-doped mesoporous silica nanorods (AuNRs-Ce6-MSNRs) for the single wavelength of near infrared (NIR) light triggered combined phototherapy. AuNRs-Ce6-MSNRs are not only able to generate hyperthermia to perform PTT effect based on the AuNRs, but also can produce singlet oxygen (1O2) for PDT effect based on Ce6 after uncapping of AuNRs under the single NIR wavelength irradiation. In addition, the combined therapy can be dual-imaging guided by taking the photoacoustic (PA) and NIR fluorescence (NIRF) imaging of AuNRs and Ce6, respectively. What's more, by utilizing the special structure of MSNRs, this nanocarrier can serve as a drug delivery platform with high drug loading capacity and enhanced cellular uptake efficiency. The multi-functional nanocomposite is designed to integrate photothermal and photodynamic therapy, in vivo dual-imaging into one system, achieving synergistic anti-tumor effects both in vitro and in vivo.
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: You
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Pang
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Tan
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China. Electronic address: tanfengping@163.com.
authors.forename: Fengping
authors.initials: F
authors.lastname: Tan
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China. Electronic address: linan19850115@163.com.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002735:Chlorophyllides; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006046:Gold / Q000737:chemistry; D006979:Hyperthermia, Induced / Q000379:methods; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D051379:Mice; D008819:Mice, Nude; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects; D058608:Nanopores / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry* / Q000528:radiation effects; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D010789:Phototherapy / Q000379:methods*; D011166:Porphyrins / Q000008:administration & dosage*; D012822:Silicon Dioxide / Q000737:chemistry / Q000528:radiation effects
chemical_list: D002735:Chlorophyllides; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D006046:Gold; D012822:Silicon Dioxide
keywords: Au nanorod; Ce6; Combined phototherapy; Dual-imaging guided; Mesoporous silica nanorod; Single wavelength of light trigger