title: Rapid Synthesis of68Ga-labeled macroaggregated human serum albumin (MAA) for routine application in perfusion imaging using PET/CT.
abstract: 99mTc-labeled MAA is commonly used for single photon emission computed tomography SPECT. In contrast, positron emission tomography/CT (PET/CT) delivers images with significantly higher resolution. The generator produced radionuclide68Ga is widely used for PET/CT imaging agents and68Ga-labeled MAA represents an attractive alternative to99mTc-labeled MAA. We report a simple and rapid NaCl based labeling procedure for the labeling of MAA with68Ga using a commercially available MAA labeling kit for99mTc. The procedure delivers68Ga-labeled MAA with a high specific activity and a high labeling efficiency (>99%). The synthesis does not require a final step of separation or the use of organic solvents.
authors.affiliation: Department of Radiophamacy, Zentralklinik Bad Berka, Germany. Electronic address: dirk.mueller@zentralklinik.de.
authors.forename: D
authors.initials: D
authors.lastname: Mueller
authors.affiliation: Theranostics Center for Molecular Radiotherapy and Molecular Imaging, Zentralklinik Bad Berka, Germany.
authors.forename: Harshad
authors.initials: H
authors.lastname: Kulkarni
authors.affiliation: Theranostics Center for Molecular Radiotherapy and Molecular Imaging, Zentralklinik Bad Berka, Germany.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Baum
authors.affiliation: Department of Nuclear Medicine, University Hospital Halle(Saale), Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Odparlik
keywords: Gallium-68; MAA; Macroaggregated human serum albumin; Perfusion imaging; Positron emission tomography; Radiopharmaceutical