title: Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value.
abstract: Objective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT).Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m2and (2) low GFR group with GFR < 45 mL/min/1.73 m2. Outcome measurements were poor outcome (mRS 3-6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24-36 hours. Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs).Results. Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m2significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09-1.30,p< 0.001) and mortality (OR 1.18, 95% CI 1.06-1.32,p= 0.002). In multivariate regression, adjusted for all variables withpvalue < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01-4.56,p= 0.045).Conclusion. In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m2before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m2.
authors.affiliation: Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Elyar
authors.identifier: 0000-0002-5481-6027
authors.initials: E
authors.lastname: Sadeghi-Hokmabadi
authors.affiliation: Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Demet Funda
authors.identifier: 0000-0001-9231-0337
authors.initials: DF
authors.lastname: Baş
authors.affiliation: Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farhoudi
authors.affiliation: Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Taheraghdam
authors.affiliation: Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Daryoush
authors.initials: D
authors.lastname: Savadi Oskouei
authors.affiliation: Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yazdchi
authors.affiliation: Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Maziyar
authors.identifier: 0000-0002-9522-6963
authors.initials: M
authors.lastname: Hashemilar
authors.affiliation: Department of Neurology, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Nevzat
authors.identifier: 0000-0002-4961-4332
authors.initials: N
authors.lastname: Uzuner
authors.affiliation: Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Reshad
authors.identifier: 0000-0002-9829-2034
authors.initials: R
authors.lastname: Mirnour
authors.affiliation: Department of Biostatistics, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Ertugrul
authors.identifier: 0000-0003-3251-1043
authors.initials: E
authors.lastname: Colak
authors.affiliation: Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Atilla Özcan
authors.initials: AÖ
authors.lastname: Özdemir