title: Copper-catalyzed asymmetric sp3C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst.
abstract: This report describes a highly enantioselective oxidative sp3C-H arylation ofN-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3C-H asymmetric arylation of THIQs.
authors.affiliation: Department of Chemistry, FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Querard
authors.affiliation: Department of Chemistry, FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Inna
authors.initials: I
authors.lastname: Perepichka
authors.affiliation: Organic Semiconductor Centre, EaStCHEM School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, UK.
authors.forename: Eli
authors.initials: E
authors.lastname: Zysman-Colman
authors.affiliation: Department of Chemistry, FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Li
keywords: C–H arylation; copper catalyst; enantioselectivity; visible light