title: Evaluation of the Pathogenesis of Tumor Development from Endometriosis by Estrogen Receptor, P53 and Bcl-2 Immunohistochemical Staining
abstract: Objective: Endometriosis, one of the most common estrogen dependent gynecological disorders, can present
  as both benign and malignant disease. The prevalence of tumoral transformation is 0.7-1.6% and the most common
  tumors are clear cell and endometrioid carcinomas. Unfortunately, the pathogenesis of transformation is unknown.
  For this purpose, we examined molecular alterations in ovarian endometriosis and endometriosis-associated tumors.
  Methods: Using the data bank of Alzahra hospital pathology department and paraffin blocks from appropriate cases
  were identified. Sections were cut and stained for 3 markers: estrogen receptor, P53 and bcl2. Correlations between
  findings were investigated. Results: Nineteen cases of endometriosis-associated tumor and 19 cases of endometriosis
  were identified. Staining for bcl2 was documented in 14 of 19 (73.7%) of endometriosis-associated tumor cases
  and also 7 of 19 (36.8%) endometriosis cases (P=0.02). Only 3 of the 19 (15.8%) endometriosis-associated tumors
  exhibited positive staining for estrogen receptors, compared with 14 of 19 (73.7%) endometriosis cases (P<0.001).
  Positive staining for P53 was noted in 5 of 19 (31.6%) endometriosis-associated ovarian tumor samples but was absent
  in endometriosis samples (0%), (P =0.008). Conclusions: Endometriosis-associated tumors appear to be associated
  with overexpression of bcl2 and P53 and reduced expression of Estrogen receptor. These finding may help to diagnose
  tumoral transformation with a background of endometriosis.
authors.affiliation: Departments of Pathology, Imam Reza Teaching Hospital, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Email:azimpouranm@tbzmed.ac.ir
authors.forename: Esmaili
authors.initials: E
authors.lastname: Haidarali
authors.forename: Amir
authors.initials: A
authors.lastname: Vahedi
authors.forename: Shiva
authors.initials: Sh
authors.lastname: Mohajeri
authors.forename: Elmira
authors.initials: E
authors.lastname: Mostafidi
authors.forename: Mahzad
authors.initials: M
authors.lastname: Azimpouran
authors.forename: Mohammad
authors.initials: M
authors.lastname: Naghavi Behzad
keywords: Ovarian tumor; endometriosis; estrogen receptor; P53; Bcl2