title: Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus.
abstract: Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells.
authors.affiliation: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: GoodSmith
authors.affiliation: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
authors.affiliation: Werner-Reichardt Centre for Integrative Neuroscience, 72076 Tübingen, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Burgalossi
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Christian
authors.affiliation: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA. Electronic address: jknierim@jhu.edu.
authors.forename: James J
authors.initials: JJ
authors.lastname: Knierim
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D056654:CA3 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D003663:Decision Trees; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D008568:Memory; D008959:Models, Neurological; D019599:Mossy Fibers, Hippocampal / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D065855:Spatial Processing / Q000502:physiology*
keywords: dentate gyrus; granule cell; hilus; mossy cell; pattern separation