title: Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides.
abstract: New 1-thia-azaspiro[4.5]decane derivatives, their derived thiazolopyrimidine and 1,3,4-thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized (1,3,4-thiadiazolyl)thiaazaspiro[4.5]decane and thiazolopyrimidinethione compounds were synthesized by glycosylation reactions using acetylated glycosyl bromides. The anticancer activity of synthesized compounds was studied against the cell culture of HepG-2 (human liver hepatocellular carcinoma), PC-3 (human prostate adenocarcinoma) and HCT116 (human colorectal carcinoma) cell lines and a number of compounds showed moderate to high inhibition activities.
authors.affiliation: Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Monawarah 1343, Saudi Arabia. emanmflefel@yahoo.com.|Photochemistry Department, National Research Centre, Dokki 12622, Giza, Egypt. emanmflefel@yahoo.com.
authors.forename: Eman M
authors.initials: EM
authors.lastname: Flefel
authors.affiliation: Photochemistry Department, National Research Centre, Dokki 12622, Giza, Egypt. waelshendy@gmail.com.
authors.forename: Wael A
authors.initials: WA
authors.lastname: El-Sayed
authors.affiliation: Applied Organic Chemistry Department, National Research Centre, Dokki 12622, Giza, Egypt. ammewas1@gmail.com.|Chemistry Department, College of Science, Aljouf University, Sakaka, Al-Jouf 72341, Saudi Arabia. ammewas1@gmail.com.
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: Mohamed
authors.affiliation: Photochemistry Department, National Research Centre, Dokki 12622, Giza, Egypt. walaa.elsofany@gmail.com.
authors.forename: Walaa I
authors.initials: WI
authors.lastname: El-Sofany
authors.affiliation: Department of Tanning Materials and Leather Technology, National Research Centre, Dokki 12622, Giza, Egypt. hanem_awad@yahoo.com.
authors.forename: Hanem M
authors.initials: HM
authors.lastname: Awad
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D006031:Glycosylation; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013865:Thioglycosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013141:Spiro Compounds; D013830:Thiadiazoles; D053778:Thiazolidines; D013865:Thioglycosides; C058949:1,3,4-thiadiazole
keywords: 1,3,4-thiadiazoles anticancer activity; 1-thia-azaspiro[4.5]decane; thiazolopyrimidine; thioglycosides