title: The effectiveness of rapid sequence intubation (RSI) versus non-RSI in emergency department: an analysis of multicenter prospective observational study.
abstract: BACKGROUND
  Although rapid sequence intubation (RSI) is the method of choice in emergency department (ED) airway management, data to support the use of RSI remain scarce. We sought to compare the effectiveness of airway management between RSI and non-RSI (intubation with sedative agents only or without medications) in the ED.
  
  
  METHODS
  Secondary analysis of the data from a multicenter prospective observational registry at 13 Japanese EDs. All non-cardiac-arrest patients who underwent intubation with RSI or non-RSI were included for the analysis. Outcomes of interest were the success rate of intubation and intubation-related complications.
  
  
  RESULTS
  Of 2365 eligible patients, 761 (32%) underwent intubations with RSI and 1,604 (68%) with non-RSI. Intubations with RSI had a higher success rate on the first attempt compared to those with non-RSI (73 vs. 63%; P < 0.0001). By contrast, the complication rates did not differ significantly between RSI and non-RSI groups (12 vs. 13%; P = 0.59). After adjusting for age, sex, estimated weight, principal indication, device, specialties and training level of the intubator, and clustering of patients within EDs, intubation with RSI was associated with a significantly higher success rate on the first attempt (OR, 2.3; 95% CI, 1.8-2.9; P < 0.0001) while that with RSI was not associated with the risk of complications (OR, 0.9; 95% CI, 0.6-1.2; P = 0.31).
  
  
  CONCLUSIONS
  In this large multicenter study of ED airway management, we found that intubation with RSI was independently associated with a higher success rate on the first attempt but not with the risk of complications.
authors.affiliation: Department of Emergency Medicine, University of Pittsburgh, Iroquois Building Suite 400 A, 3600 Forbes Avenue, Pittsburgh, PA, 15261, USA. masashiokubo914@gmail.com.
authors.forename: Masashi
authors.initials: M
authors.lastname: Okubo
authors.affiliation: Biostatistics Center, Kurume University, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Gibo
authors.affiliation: Department of Pediatric Emergency and Critical Care Medicine, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hagiwara
authors.affiliation: Department of Emergency Medicine, Okinawa Prefectural Chubu Hospital, 281 Miyazato, Uruma, Okinawa, 904-2293, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nakayama
authors.affiliation: Department of Emergency Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Kohei
authors.initials: K
authors.lastname: Hasegawa
keywords: Airway management; Complications of intubation; Emergency department; Intubation; Intubation success; Rapid sequence intubation; Resuscitation