title: [Mechanism of mitochondrial fission - structure and function of Drp1 protein].
abstract: In the cell mitochondria constitute a dynamic network undergoing continuous reshaping by fusion and fission. Mitochondrial fission is involved in several crucial cellular processes such as mitosis, apoptosis and mitophagy. Main mediator of mitochondrial fission is Dynamin related protein 1 (Drp1). This protein is able to assemble into higher order oligomers, what enables the formation of Drp1 spiral structures on the surface of mitochondrial network. These spirals constrict thanks to the energy gained from GTP hydrolysis, what results in mitochondrial fission. Mitochondrial fission process is precisely regulated by different mechanisms, especially by controlling Drp1 activity. This article presents our current understanding of mitochondrial fission with a particular focus on the role of Drp1 in this process and mechanisms that regulate activity of this protein.
authors.affiliation: Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology PAS, 3 Pasteur St., 02-093 Warsaw, Poland.
authors.forename: Bernadeta
authors.initials: B
authors.lastname: Michalska
authors.affiliation: Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology PAS, 3 Pasteur St., 02-093 Warsaw, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Duszyński
authors.affiliation: Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology PAS, 3 Pasteur St., 02-093 Warsaw, Poland.
authors.forename: Jędrzej
authors.initials: J
authors.lastname: Szymański
mesh_terms: D017209:Apoptosis; D034281:Dynamins / Q000378:metabolism / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000378:metabolism / Q000502:physiology*; D008938:Mitosis; D011487:Protein Conformation
chemical_list: D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; C110768:DNM1L protein, human; C486391:Dnm1l protein, mouse; D034281:Dynamins
keywords: Drp1; fission complex; mitochondrial fission