title: [Treatment of Dupuytren's disease with collagenase Clostridium histolyticum].
abstract: BACKGROUND
  Dupuytren's disease as a benign fibroproliferative disease leads to hyperplasia of the collagen fibers of the fascia of the palm, which can result in severe impairment of the functionality of the hand.
  
  
  OBJECTIVE
  Examination of the significance of non-operative treatment of Dupuytren's disease with injectable collagenase clostridium histolyticum (CCH) METHODS: Observation of 120 patients treated with injectable collagenase. Documentation of the range of motion before the intervention, 12 months after the intervention, and documentation of any adverse events.
  
  
  RESULTS
  All in all, 120 patients were treated (107 male, 13 female) (mean age 62 years, range 30-84 years). In 49% the little finger, in 44% the ring finger, in 4% the middle finger, and in 3% the index finger were treated. Full release was accomplished in 71%, partial release in 26%, and no change in 3% of the patients. The median contracture before the treatment was 37° for the metacarpophalangeal (MP) joint (range 25-100°) and 51° for the proximal interphalangeal (PIP) joint (range 30-97°). After 12 months, the mean contracture for the MP joint was 9° (range 0-25°) and 21° (range 10-36°) or the PIP joint. Adverse events occurred in 96% of patients within 3 months after treatment. No tendon ruptures, anaphylactic reactions, nerve, or ligament injuries were observed.
authors.affiliation: Department für Unfallchirurgie, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.
authors.forename: M
authors.initials: M
authors.lastname: Keller
authors.affiliation: Department für Unfallchirurgie, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich. rohit.arora@tirol-kliniken.at.
authors.forename: R
authors.initials: R
authors.lastname: Arora
authors.affiliation: Department für Unfallchirurgie, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.
authors.forename: G
authors.initials: G
authors.lastname: Schmiedle
authors.affiliation: Department für Unfallchirurgie, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.
authors.forename: T
authors.initials: T
authors.lastname: Kastenberger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004387:Dupuytren Contracture / Q000188:drug therapy* / Q000473:pathology*; D019317:Evidence-Based Medicine; D006801:Humans; D015552:Injections, Intralesional; D008137:Longitudinal Studies; D003012:Microbial Collagenase / Q000008:administration & dosage*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D003012:Microbial Collagenase
keywords: Collagenase; Dupuytreny; Finger; Non surgical treatment; Palmar fibromatosis