title: Development of Semiautomated Module for Preparation of131I Labeled Lipiodol for Liver Cancer Therapy.
abstract: Intra-arterial injection of131I Lipiodol is an effective treatment option for primary hepatocellular carcinoma as it delivers high radiation dose to liver tumor tissue with minimal accumulation in adjacent normal tissue. The present article demonstrates design, fabrication, and utilization of a semiautomated radiosynthesis module for preparation of131I labeled Lipiodol. The radiolabeling method was standardized for preparation of patient dose of131I labeled Lipiodol radiochemical yield (RCY); radiochemical purity (RCP) and pharmaceutical purity of the product were determined using optimized procedures. Sterile and apyrogenic131I labeled Lipiodol in >60% RCY could be prepared with >95% RCP. Preclinical evaluation in animals indicated retention of more than 90% of activity at 24 hours postportal vein injection. This is the first report demonstrating potential application of simple user friendly and safe semiautomated system for routine production of131I labeled Lipiodol, which is adaptable at centralized hospital radiopharmacies. The described prototype module can be modified as per demand for preparation of other therapeutic radiopharmaceuticals.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC) , Mumbai, India .
authors.forename: Archana
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC) , Mumbai, India .
authors.forename: Suresh
authors.initials: S
authors.lastname: Subramanian
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC) , Mumbai, India .
authors.forename: Rajwardhan
authors.initials: R
authors.lastname: Ambade
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC) , Mumbai, India .
authors.forename: Bhaurao
authors.initials: B
authors.lastname: Avhad
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC) , Mumbai, India .
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre (BARC) , Mumbai, India .
authors.forename: Aruna
authors.initials: A
authors.lastname: Korde
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy*; D004998:Ethiodized Oil / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007269:Injections, Intra-Arterial; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007553:Isotope Labeling / Q000295:instrumentation*; D008113:Liver Neoplasms / Q000532:radiotherapy*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D004998:Ethiodized Oil
keywords: 131I labeled Lipiodol; hepatocellular carcinoma; liver cancer therapy; radioembolization; radiosynthesis; semiautomated module