title: Treatment of cefuroxime-induced neurotoxicity with continuous venovenous haemofiltration.
abstract: A 61-year-old woman with decreased consciousness, myoclonus, tremors, nystagmus and bradypnoea, due to cefuroxime-induced neurotoxicity, was admitted to the intensive care unit. Continuous venovenous haemofiltration (CVVH) rapidly reduced plasma cefuroxime concentrations and improved neurological manifestations within the next few hours. Retrospective pharmacokinetic assessment showed a total cefuroxime clearance of 166 ml/min during the CVVH.
authors.affiliation: Department of Intensive Care, VieCuri Medical Centre, the Netherlands.
authors.forename: D G H A
authors.initials: DG
authors.lastname: van Dam
authors.forename: D M T
authors.initials: DM
authors.lastname: Burgers
authors.forename: N
authors.initials: N
authors.lastname: Foudraine
authors.forename: P K C
authors.initials: PK
authors.lastname: Janssen
authors.forename: C
authors.initials: C
authors.lastname: Neef
authors.forename: J L M L
authors.initials: JL
authors.lastname: le Noble
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000097:blood; D002444:Cefuroxime / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime