title: AmyloidβPeptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input.
abstract: Alterations in prefrontal cortex (PFC) function and abnormalities in its interactions with other brain areas (i.e., the hippocampus) have been related to Alzheimer Disease (AD). Considering that these malfunctions correlate with the increase in the brain's amyloid beta (Aβ) peptide production, here we looked for a causal relationship between these pathognomonic signs of AD. Thus, we tested whether or not Aβaffects the activity of the PFC network and the activation of this cortex by hippocampal input stimulationin vitro. We found that Aβapplication to brain slices inhibits PFC spontaneous network activity as well as PFC activation, both at the population and at the single-cell level, when the hippocampal input is stimulated. Our data suggest that Aβcan contribute to AD by disrupting PFC activity and its long-range interactions throughout the brain.
authors.affiliation: Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, 76230 Querétaro, QRO, Mexico.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Flores-Martínez
authors.affiliation: Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, 76230 Querétaro, QRO, Mexico.
authors.forename: Fernando
authors.identifier: 0000-0002-0348-4392
authors.initials: F
authors.lastname: Peña-Ortega