title: Cobalt-Catalyzed Enantio- and Diastereoselective Intramolecular Hydroacylation of Trisubstituted Alkenes.
abstract: Enantio- and diastereoselective synthesis of trans-2,3-disubstituted indanones is achieved by intramolecular hydroacylation of 2-alkenylbenzaldehydes bearing trisubstituted alkenyl groups under cobalt-chiral diphosphine catalysis. Notably, a high level of enantioselectivity is induced regardless of the stereochemistry (E/Z ratio) of the alkenyl group of the starting material. Deuterium-labeling experiments shed light on the productive reaction pathways of the E- and Z-isomers.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Yang
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.|Laboratoire de Chimie Moléculaire, CNRS, Ecole Polytechnique, Université Paris Saclay, 91128, Palaiseau, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Rérat
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
authors.forename: Yang Jie
authors.initials: YJ
authors.lastname: Lim
authors.affiliation: Laboratoire de Chimie Moléculaire, CNRS, Ecole Polytechnique, Université Paris Saclay, 91128, Palaiseau, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Gosmini
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
authors.forename: Naohiko
authors.identifier: 0000-0002-8997-3268
authors.initials: N
authors.lastname: Yoshikai
keywords: C−H activation; asymmetric synthesis; cobalt; cyclizations; hydroacylation