title: The role of WRNIP1 in genome maintenance.
abstract: WRNIP1 interacts with WRN helicase, which is defective in the premature aging disease Werner syndrome. WRNIP1 belongs to the AAA+ ATPase family and is conserved from Escherichia coli to human. The protein contains an ubiquitin-binding zinc finger (UBZ) domain at the N terminus and an ATPase domain in the middle region. In addition to WRN, WRNIP1 interacts with proteins involved in multiple cellular pathways, including RAD18, monoubiquitylated PCNA, DNA polymerase δ, RAD51, and ATMIN. Mgs1, the yeast homolog of WRNIP1, may act downstream of ubiquitylation of PCNA to mobilize DNA polymerase δ. By contrast, the functions of WRNIP1 in higher eukaryotic cells remain obscure, although data regarding the roles of WRNIP1 in DNA transactions have emerged recently. Here, we first describe the functions of Mgs1 in DNA transaction. We then describe various features of WRNIP1 and discuss its possible roles based on recent studies of the function of WRNIP1.
authors.affiliation: a Molecular Cell Biology Laboratory , Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University , Nishitokyo-shi Tokyo , Japan.
authors.forename: Akari
authors.initials: A
authors.lastname: Yoshimura
authors.affiliation: b Laboratory of Biochemistry , Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University , Aoba-ku , Sendai , Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Seki
authors.affiliation: a Molecular Cell Biology Laboratory , Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University , Nishitokyo-shi Tokyo , Japan.
authors.forename: Takemi
authors.initials: T
authors.lastname: Enomoto
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D042822:Genomic Instability; D006801:Humans; D008954:Models, Biological
chemical_list: D004247:DNA; D000251:Adenosine Triphosphatases
keywords: ATMIN; DNA polymerase δ; DNA polymerase η; Mgs1; PCNA; RAD18; WRN; WRNIP1; ubiquitin