title: Cervical cancer incidence after screening with HPV, cytology, and visual methods: 18-Year follow-up of the Guanacaste cohort.
abstract: Testing negative for human papillomavirus (HPV) predicts long-term reassurance against invasive cervical cancer (ICC). To provide realistic estimates of effectiveness for new screening programs, we studied ICC risk after a 7-year repeated multimethod screening effort. In 1993-1994, 10,049 women aged 18-97 years were enrolled into a population-based cohort study of cervical HPV in Guanacaste, Costa Rica. Women were screened at different intervals according to enrollment results. Each visit (mean 3.2, 90% attendance) included split-sample conventional, automated, and liquid-based cytology, visual inspection, cervicography, and PCR-based HPV testing. Abnormal screening led to colposcopy and excisional treatment as appropriate during the study. Referral to colposcopy for HPV in the absence of other findings was introduced only at the last visit. Population-based Costa Rica Cancer Registry linkage identified cohort women diagnosed with ICC in the 18 years following cohort enrollment. The ICC cumulative risk was 0.4% (n = 38); 18 were diagnosed with ICC after study participation. Of these, 9 were missed at the screening step (negative screening or below the referral threshold, refused screening or colposcopy), 5 attended colposcopy but were not diagnosed as CIN2+, and 4 were treated for CIN2/3 but progressed to ICC nonetheless. Decreasing age-standardized ICC rates for the 1993-2011 period were observed in Guanacaste; cohort women showed additional 31% ICC incidence reduction with apparent downstaging of cancers that occurred. ICC risk following negative HPV testing in the optimal age range 30-50 years was extremely low. Real-life screening effectiveness following introduction is lower than the potential near-complete efficacy predicted by HPV natural history.
authors.affiliation: National Cancer Institute Consultant, San José, Costa Rica.
authors.forename: Ana Cecilia
authors.initials: AC
authors.lastname: Rodríguez
authors.affiliation: Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, San José, Costa Rica.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ávila
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Rolando
authors.initials: R
authors.lastname: Herrero
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, MD.
authors.forename: Allan
authors.initials: A
authors.lastname: Hildesheim
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, DHHS, Rockville, MD.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Sherman
authors.affiliation: Albert Einstein College of Medicine, Albert Einstein Cancer Center, The Bronx, NY.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burk
authors.affiliation: Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, San José, Costa Rica.
authors.forename: Jorge
authors.initials: J
authors.lastname: Morales
authors.affiliation: Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, San José, Costa Rica.
authors.forename: Mario
authors.initials: M
authors.lastname: Alfaro
authors.affiliation: Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, San José, Costa Rica.
authors.forename: Diego
authors.initials: D
authors.lastname: Guillén
authors.affiliation: Ministerio de Salud, San José, Costa Rica.
authors.forename: María Ethel
authors.initials: ME
authors.lastname: Trejos
authors.affiliation: Ministerio de Salud, San José, Costa Rica.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Vargas
authors.affiliation: Ministerio de Salud, San José, Costa Rica.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Torres
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, MD.
authors.forename: Mark
authors.initials: M
authors.lastname: Schiffman
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003127:Colposcopy; D003364:Costa Rica; D003581:Cytodiagnosis; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000821:virology; D011247:Pregnancy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000821:virology; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral
keywords: cervical cancer risk 18-years after enrollment into the Guanacaste cohort; cervical cancer screening; screening frequency