title: Role of moesin, Src, and ROS in advanced glycation end product-induced vascular endothelial dysfunction.
abstract: The disruption of endothelial integrity and the occurrence of angiogenesis in response to AGEs contribute greatly to micro- and macrovascular complications associated with DM. Among human dermal, brain, and retinal vascular ECs, activation of ERM, moesin, by phosphorylation of Thr-558 is involved in AGE-induced hyperpermeability and angiogenesis via the Rho and ROCK (Rho/ROCK) and p38 pathways. Src also plays an important role in AGE-induced endothelial barrier dysfunction by phosphorylating moesin, VE-cadherin, and FAK. Furthermore, recent studies have demonstrated that ROS serve as a key mediator of the AGE-induced endothelial response. ROS inhibition would greatly benefit ECs. This review focuses on the role of moesin in microvascular permeability and angiogenesis, and on the involvement of Src and ROS in endothelial barrier disruption.
authors.affiliation: First Clinical College of Medicine, Southern Medical University, Guangzhou, China.
authors.forename: Wei-Jin
authors.initials: WJ
authors.lastname: Zhang
authors.affiliation: First Clinical College of Medicine, Southern Medical University, Guangzhou, China.
authors.forename: Pei-Xin
authors.initials: PX
authors.lastname: Li
authors.affiliation: Department of Pathophysiology, Key Laboratory for Shock and Microcirculation Research of Guangdong Province, Southern Medical University, Guangzhou, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Guo
authors.affiliation: Department of Pathophysiology, Key Laboratory for Shock and Microcirculation Research of Guangdong Province, Southern Medical University, Guangzhou, China.
authors.forename: Qiao-Bing
authors.identifier: 0000-0001-8931-7378
authors.initials: QB
authors.lastname: Huang
mesh_terms: D002199:Capillary Permeability; D004730:Endothelium, Vascular / Q000503:physiopathology*; D017127:Glycation End Products, Advanced / Q000502:physiology*; D006801:Humans; D008840:Microfilament Proteins / Q000502:physiology*; D009389:Neovascularization, Pathologic; D017382:Reactive Oxygen Species / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D008840:Microfilament Proteins; D017382:Reactive Oxygen Species; C071058:moesin; D019061:src-Family Kinases
keywords: 
  ROS
  ; AGEs; Src; endothelial dysfunction; moesin