title: Pathogenesis and Pathology of Mastocytosis.
abstract: Systemic mastocytosis is a clonal disorder of mast cells that may variably present with characteristic skin lesions, episodes of mast cell mediator release, and disturbances of hematopoiesis. No curative therapy presently exists. Conventional management has relied on agents that antagonize mediators released by mast cells, inhibit mediator secretion, or modulate mast cell proliferation. Recent advances in the molecular understanding of the pathophysiology of systemic mastocytosis have provided new therapeutic considerations, including new and novel tyrosine kinase inhibitors.
authors.affiliation: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; email: dmetcalfe@niaid.nih.gov.
authors.forename: Dean D
authors.initials: DD
authors.lastname: Metcalfe
authors.affiliation: Tel Hai College, Upper Galilee, 1220800 Israel; email: ymekori@telhai.ac.il.|Meir Medical Center, Kfar Saba 44281, Israel.|Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
authors.forename: Yoseph A
authors.initials: YA
authors.lastname: Mekori
mesh_terms: D000818:Animals; D006801:Humans; D008407:Mast Cells / Q000473:pathology*; D008415:Mastocytosis / Q000473:pathology*
keywords: KIT; mast cell mediators; mast cells; mastocytosis