title: Bio-Inspired Fragmentations: Rapid Assembly of Indolones, 2-Quinolinones, and (-)-Goniomitine.
abstract: Inspired by the biogenetic origin of goniomitine, new synthetic bio-inspired fragmentation strategies for the synthesis of functionalized 2-quinolinones and indolones have been developed. Remarkable synthetic efficiency was achieved by telescoping several transformations into one-pot reactions, allowing for the direct coupling of 2-alkynyl-anilines and diazo ketones. The synthetic utility was demonstrated by the 5-step asymmetric total synthesis of (-)-goniomitine from 2-ethyl-cyclopentanone.
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Haokun
authors.initials: H
authors.lastname: Li
authors.affiliation: Collaborative Innovation Center for Biotherapy, West China Medical School, Sichuan University, Chengdu, 610041, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cheng
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Long
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Collaborative Innovation Center for Biotherapy, West China Medical School, Sichuan University, Chengdu, 610041, China.
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.|Collaborative Innovation Center for Biotherapy, West China Medical School, Sichuan University, Chengdu, 610041, China.
authors.forename: Liansuo
authors.initials: L
authors.lastname: Zu
keywords: fragmentation; goniomitine; indolones; quinolinones; total synthesis