title: Attitudes to Stem Cell Therapy Among Ischemic Stroke Survivors in the Lund Stroke Recovery Study.
abstract: Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors influencing this among stroke patients potentially suitable for SCT. Consecutive first-ever acute ischemic stroke patients aged 20-75 years with NIH stroke scale scores 1-18 were included. Exclusion criteria were severe comorbidities or infratentorial stroke. Clinical follow-up after 3-5 years assessed severity of residual stroke symptoms, cognitive function, functional status, patient-reported outcome, and comorbidity, and after receiving standardized information, the participants also completed an eight-item questionnaire on knowledge and attitudes about SCT. The relationships between clinical variables and positive attitude to SCT were assessed with logistic regression analyses. Of 108 patients included at baseline, 84 participated at follow-up and completed the questionnaire. In total, 12% had prior knowledge of SCT. When informed, 63% were positive toward it and 36% reported willingness to participate in SCT trials. Only 5%-8% expressed ethical considerations regarding different stem cell sources. Positive attitudes to SCT were associated with male gender (OR: 3.74; 95% CI: 1.45-9.61; P < 0.01) and better patient-reported outcome (OR: 1.02; 95% CI: 1.00-1.04; P < 0.05). In conclusion, stroke patients had limited prior knowledge of SCT, yet attitudes were positive among the majority after receiving standardized and neutral information. Gender and degree of stroke recovery may influence attitudes to SCT, indicating a need for targeted information to improve knowledge about SCT.
authors.affiliation: 1 Department of Clinical Sciences Lund, Neurology, Lund University , Lund, Sweden .|2 Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital , Lund, Sweden .
authors.forename: Joseph
authors.initials: J
authors.lastname: Aked
authors.affiliation: 1 Department of Clinical Sciences Lund, Neurology, Lund University , Lund, Sweden .|2 Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital , Lund, Sweden .
authors.forename: Hossein
authors.initials: H
authors.lastname: Delavaran
authors.affiliation: 1 Department of Clinical Sciences Lund, Neurology, Lund University , Lund, Sweden .|2 Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital , Lund, Sweden .|3 Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University , Lund, Sweden .
authors.forename: Olle
authors.initials: O
authors.lastname: Lindvall
authors.affiliation: 1 Department of Clinical Sciences Lund, Neurology, Lund University , Lund, Sweden .|2 Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital , Lund, Sweden .
authors.forename: Bo
authors.initials: B
authors.lastname: Norrving
authors.affiliation: 1 Department of Clinical Sciences Lund, Neurology, Lund University , Lund, Sweden .|3 Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University , Lund, Sweden .
authors.forename: Zaal
authors.initials: Z
authors.lastname: Kokaia
authors.affiliation: 1 Department of Clinical Sciences Lund, Neurology, Lund University , Lund, Sweden .|2 Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital , Lund, Sweden .
authors.forename: Arne
authors.initials: A
authors.lastname: Lindgren
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000523:psychology / Q000628:therapy*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D010361:Patients / Q000523:psychology*; D033581:Stem Cell Transplantation / Q000523:psychology*; D020521:Stroke / Q000523:psychology / Q000628:therapy*
keywords: patient attitude; stem cell therapy; stroke