title: Mixed Botryoid and Spindle Cell Bladder Rhabdomyosarcoma: An Outstanding Pediatric Case.
abstract: We report a case of a 3-year-old North African child, initially assessed for nonspecific urinary symptoms such as haematuria and burning urination. The ultrasound evaluation showed a vegetating mass occupying the lumen with weak vascular signs at the Colour-Doppler evaluation. An explorative cystoscopy was performed and it revealed a nonbleeding lesion, white in colour, pedunculated, projecting into the lumen, and associated with a brown satellite formation. Histological examination showed a mixed Botryoid and Spindle Cell Rhabdomyosarcoma. This mixed histology has not been described before and no statistical data are reported in literature so far. Despite the Embryonal Rhabdomyosarcoma variant being the most common, the association characterized by two histological Rhabdomyosarcoma subtypes such as Botryoid and Spindle Cell is rarely observed and it is important to get an accurate histological diagnosis in order to immediately start the correct treatment protocol.
authors.affiliation: Department of Pediatric Sciences, University of Messina, Messina, Italy.
authors.forename: Tommaso
authors.identifier: 0000-0002-3082-855X
authors.initials: T
authors.lastname: Alterio
authors.affiliation: Department of Pediatric Sciences, University of Messina, Messina, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Chimenz
authors.affiliation: Department of Pediatric Surgery, University of Messina, Messina, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Arena
authors.affiliation: Department of Pediatric Sciences, University of Messina, Messina, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Conti
authors.affiliation: Department of Pediatric Sciences, University of Messina, Messina, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Cardile
authors.affiliation: Department of Pediatric Surgery, University of Messina, Messina, Italy.
authors.forename: Carmelo
authors.identifier: 0000-0002-7616-5480
authors.initials: C
authors.lastname: Romeo
authors.affiliation: Department of Pediatric Sciences, University of Messina, Messina, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Salpietro
authors.affiliation: Department of Pediatric Sciences, University of Messina, Messina, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Fede