title: Mania in Wolfram's Disease: From Bedside to Bench.
abstract: Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specificWFS1gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.
authors.affiliation: Department of Psychiatry, Medical College, Calcutta National Medical College, Kolkata, India.
authors.forename: Seshadri Sekhar
authors.initials: SS
authors.lastname: Chatterjee
authors.affiliation: Consultant Psychiatrist, Calcutta National Medical College, Kolkata, India.
authors.forename: Sayantanava
authors.initials: S
authors.lastname: Mitra
authors.affiliation: Department of Endocrinology, Calcutta National Medical College, Kolkata, India.
authors.forename: Salil Kumar
authors.initials: SK
authors.lastname: Pal
keywords: Bipolar Disorder; Comorbidity; Wolfram syndrome