title: Tailor-made drug carrier: Comparison of formation-dependent physicochemical properties within self-assembled aggregates for an optimal drug carrier.
abstract: Self-assembled surfactant aggregates, such as micelles and vesicles, have been investigated for their application as drug carriers in the treatment of various diseases. However, the characteristics that decide which aggregate is the best drug carrier for each disease have not yet been clarified. In order to design an optimal drug carrier for each disease, various kinds of self-assembled aggregates, such as spherical micelles, lens-like vesicles, and tube-like vesicles, were evaluated by "multiple techniques" including dynamic light scattering, differential scanning calorimetry, nuclear magnetic resonance spectroscopy, and fluorescence measurement using the Laurdan probe. These studies led to the compilation of a database on the formation-dependent properties of self-assembled aggregates. As the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers have been extensively reported, this database can be utilized for designing an optimal drug carrier, i.e., a tailor-made drug carrier.
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata Yamatokoritama-cyo, Nara, 639-1080, Japan. Electronic address: hayashi@chem.nara-k.ac.jp.
authors.forename: Keita
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata Yamatokoritama-cyo, Nara, 639-1080, Japan.
authors.forename: Hideka
authors.initials: H
authors.lastname: Iwai
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata Yamatokoritama-cyo, Nara, 639-1080, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamei
authors.affiliation: Division of Environmental Science, Graduate School of Environmental and Life Science, Okayama University, 3-1-1 Tsushima-Naka, Okayama, 700-8530, Japan.
authors.forename: Kaede
authors.initials: K
authors.lastname: Iwamoto
authors.affiliation: Division of Environmental Science, Graduate School of Environmental and Life Science, Okayama University, 3-1-1 Tsushima-Naka, Okayama, 700-8530, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Shimanouchi
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 6300192, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Fujita
authors.affiliation: Department of Chemical Engineering, National Institute of Technology, Nara College, 22 Yata Yamatokoritama-cyo, Nara, 639-1080, Japan.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan. Electronic address: umakoshi@chem.es.osaka-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Umakoshi
mesh_terms: D016208:Databases, Factual; D004337:Drug Carriers / Q000737:chemistry*; D008823:Micelles
chemical_list: D004337:Drug Carriers; D008823:Micelles
keywords: Micelle; Self-assembly; Tailor-made drug carrier; Vesicle