title: [The matrix metalloproteinase in oral and oropharyngeol cancer - literature review].
abstract: The most common head and neck cancers are neoplasms that occur in the oral cavity and the throat. They are characterized by the high growth rate and clinical malignancy. The research on a significant role in the tumorigenesis of the matrix metalloproteinases MMP-2, MMP-8, MMP-9 and their tissue inhibitors is becoming more and more popular nowadays. MMPs are a group of proteolytic enzymes responsible for the stroma extracellular matrix (ECM) degradation, which enables the tumor growth, cell migration, and tumor invasion. The numerous studies reveal a significant growing trend in the level of the studied metalloproteinases expression and their inhibitors in the oral cavity and throat cancers in relation to healthy tissues. Moreover, it was proved that an increased gene MMP-2 expression in the tumor tissue correlates with the clinical staging, the histopathological grading, presence of metastases, cancer relapse, and the patient's survival time. In available articles there is evidence of increased gene MMP-2 expression as a potential marker of the tumor invasiveness and the worse prognosis in patients with the oral cavity and throat cancers. The relationships of the gene MMP-9 expression with the clinical and pathological features as well as with the survival time are inconclusive. A similar relationship is found in case of TIMPs, however this issue has not been commonly raised in the scientific literature.
authors.affiliation: Department of Otolaryngology, Departament of Cranio-Maxillo-Facial Surgery and Oncology, Medical University of Lodz, 22 Kopcińskiego St., 90-153 Lodz, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Wróbel-Roztropiński
authors.affiliation: Department of Otolaryngology, Departament of Cranio-Maxillo-Facial Surgery and Oncology, Medical University of Lodz, 22 Kopcińskiego St., 90-153 Lodz, Poland.
authors.forename: Bogna
authors.initials: B
authors.lastname: Zielińska-Kaźmierska
authors.affiliation: Department of Otolaryngology, Departament of Cranio-Maxillo-Facial Surgery and Oncology, Medical University of Lodz, 22 Kopcińskiego St., 90-153 Lodz, Poland.
authors.forename: Weronika
authors.initials: W
authors.lastname: Lucas-Grzelczyk
authors.affiliation: Department of Otolaryngology, Departament of Cranio-Maxillo-Facial Surgery and Oncology, Medical University of Lodz, 22 Kopcińskiego St., 90-153 Lodz, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Szemraj
authors.affiliation: Department of Otolaryngology, Departament of Cranio-Maxillo-Facial Surgery and Oncology, Medical University of Lodz, 22 Kopcińskiego St., 90-153 Lodz, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Józefowicz-Korczyńska
mesh_terms: D006801:Humans; D020782:Matrix Metalloproteinases; D009062:Mouth Neoplasms / Q000378:metabolism*; D009385:Neoplastic Processes; D009959:Oropharyngeal Neoplasms / Q000378:metabolism*
chemical_list: D020782:Matrix Metalloproteinases
keywords: matrix metalloproteinases; tissue inhibitors