title: Intramolecular 1,5-C(sp3)-H Radical Amination via Co(II)-Based Metalloradical Catalysis for Five-Membered Cyclic Sulfamides.
abstract: Co(II)-based metalloradical catalysis (MRC) proves effective for intramolecular 1,5-C-H amination of sulfamoyl azides under neutral and nonoxidative conditions, providing a straightforward approach to access strained 5-membered cyclic sulfamides with nitrogen gas as the only byproduct. The metalloradical amination system is applicable to different types of C(sp3)-H bonds and has a high degree of functional group tolerance. Additional features of the Co(II)-catalyzed 1,5-C-H amination include excellent chemoselectivity toward allylic and propargylic C-H bonds. The unique reactivity and selectivity profile of the Co(II)-catalyzed 1,5-C-H amination is attributed to the underlying radical mechanism of MRC.
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.; The Institute of Chemistry & Biomedical Sciences, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Hongjian
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Lang
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Huiling
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Wojtas
authors.affiliation: Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
authors.forename: X Peter
authors.initials: XP
authors.lastname: Zhang