title: The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches.
abstract: Interplay among immune activation and cancer pathogenesis provides the framework for a novel subspecialty known as immunooncology. In the rapidly evolving field of immunooncology, understanding the tumor-specific immune response enhances understanding of cancer resistance. This review highlights the fundamentals of incorporating precision medicine to discover new immune biomarkers and predictive signatures. Using a personalized approach may have a significant, positive impact on the use of oncolytics to better guide safer and more effective therapies.
authors.affiliation: Indiana University School of Medicine, Riley CCRC 2641, 705 Riley Hospital Drive, Indianapolis, IN 46202, USA.
authors.forename: Pankita H
authors.initials: PH
authors.lastname: Pandya
authors.affiliation: Indiana University School of Medicine, Riley CCRC 2623, 705 Riley Hospital Drive, Indianapolis, IN 46202, USA.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Murray
authors.affiliation: Indiana University School of Medicine, Research Building R4, 302D1044 West Walnut St., Indianapolis, IN 46202, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Pollok
authors.affiliation: Indiana University School of Medicine, Riley CCRC 2616, 705 Riley Hospital Drive, Indianapolis, IN 46202, USA.
authors.forename: Jamie L
authors.identifier: 0000-0001-9629-8216
authors.initials: JL
authors.lastname: Renbarger
mesh_terms: D014408:Biomarkers, Tumor / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D057285:Precision Medicine
chemical_list: D014408:Biomarkers, Tumor