title: Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy.
abstract: A dual-layer shell hollow nanostructure as drug carrier that provides instant on/off function for drug release and contrast enhancement for multimodal imaging is reported. The on-demand drug release is triggered by irradiation of an external magnetic field. The nanocarrier also demonstrates a high drug loading capacity and synergistic magnetic-thermal and chemotherapy.
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Qingxin
authors.initials: Q
authors.lastname: Mu
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Revia
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Xuezhe
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.|Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, 99354, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Pauzauskie
authors.affiliation: Department of Chemistry, The College of Staten Island, City University of New York, Staten Island, NY, 10314, USA.
authors.forename: Shuiqin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Miqin
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D041623:Tomography, Optical Coherence
chemical_list: D004337:Drug Carriers; D048271:Chitosan
keywords: chitosan valve; drug carriers; multimodal imaging; on/off release; synergistic therapy