title: Memory Impairment Following Electroconvulsive Therapy in Chinese Patients with Schizophrenia: Meta-Analysis of Randomized Controlled Trials.
abstract: OBJECTIVE
  To evaluate memory impairment associated with electroconvulsive therapy (ECT)-antipsychotic (AP) combination in comparison to AP monotherapy in schizophrenia.
  
  
  METHODS
  A systematic literature search of randomized controlled trial (RCTs) was performed.
  
  
  RESULTS
  Eleven RCTs that compared ECT-AP combination (n = 508) with AP monotherapy (n = 510) were analyzed. ECT-AP combination was associated with greater impairment than AP monotherapy in (1) endpoint memory quotient (MQ) of the Wechsler Memory Scale (WMS)-Revised at the end of the ECT course; and (2) picture recall, counting, recognition, and associative learning of the WMS. However, no group difference was found in MQ at 1 and 2 weeks post-ECT.
  
  
  CONCLUSIONS
  The ECT-AP combination was associated with greater transient memory impairment compared to AP monotherapy.
authors.affiliation: Resident Psychiatrist, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Resident Psychiatrist, The National Clinical Research Center for Mental Disorders and Beijing Anding Hospital, Capital Medical University, Beijing, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Tong
authors.affiliation: Professor, School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia.|The University of Notre Dame Australia/Marian Centre, Perth, Australia.
authors.forename: Gabor S
authors.initials: GS
authors.lastname: Ungvari
authors.affiliation: Professor, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Chee H
authors.initials: CH
authors.lastname: Ng
authors.affiliation: Professor, Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Helen F K
authors.initials: HFK
authors.lastname: Chiu
authors.affiliation: Associate Professor, The National Clinical Research Center for Mental Disorders and Beijing Anding Hospital, Capital Medical University, Beijing, China.
authors.forename: Ying-Qiang
authors.initials: YQ
authors.lastname: Xiang
authors.affiliation: Attending Psychiatrist, Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China.|Shenzhen Key Laboratory for Psychological Healthcare and Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital and Shenzhen Mental Health Center, Shenzhen, China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Cao
authors.affiliation: Attending Psychiatrist, Mental Hospital of Guangzhou Civil Administration, Guangzhou, China.
authors.forename: Zheng-Rong
authors.initials: ZR
authors.lastname: Liu
authors.affiliation: Professor, School of Health Sciences, Macao Polytechnic Institute, Macao SAR, China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Meng
authors.affiliation: Honorary Associate Professor, Consultation-Liaison Psychiatric Service, Szent Istvan and Szent Laszlo Hospitals, Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Gazdag
authors.affiliation: Associate Professor, Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Xiang
mesh_terms: D002681:China; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D006801:Humans; D008569:Memory Disorders / Q000209:etiology*; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000628:therapy*
keywords: ECT-antipsychotic combination; memory impairment; meta-analysis