title: Rare Occurrence of a Poorly Differentiated Neuroendocrine Tumor of the Bladder.
abstract: Neuroendocrine tumors rarely occur in the urinary bladder. They can be carcinomatous, subdivided into small cell and large cell pathology. Small cell carcinoma of the bladder is a rarity that may present at an advanced pathologic stage. No treatment regimens have been standardized for local or metastatic disease. Review of the recent literature shows equivalent survival data for localized disease treated with chemoradiotherapy combined with either bladder sparing surgery or radical cystectomy. Patients with significant comorbidities are an additional challenge. We report a case of poorly differentiated neuroendocrine tumor of the bladder, which could not be classified as small or large cell carcinoma, complicated by significant comorbidities. After management with transurethral resection of the tumor, adjuvant chemotherapy, and radiation, the patient is alive and asymptomatic nearly 1 year after initial TURBT with no evidence of disease recurrence.
authors.affiliation: Department of Urology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.
authors.forename: Katherine
authors.identifier: 0000-0002-7176-1443
authors.initials: K
authors.lastname: Dowd
authors.affiliation: Department of Urology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Rotenberry
authors.affiliation: Department of Urology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Russell
authors.affiliation: Department of Pathology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Wachtel
authors.affiliation: Department of Urology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.
authors.forename: Werner
authors.identifier: 0000-0003-1963-2334
authors.initials: W
authors.lastname: de Riese