title: How does leptin restore euglycemia in insulin-deficient diabetes?
abstract: Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.
authors.forename: Douglas
authors.initials: D
authors.lastname: Oberlin
authors.forename: Christoph
authors.initials: C
authors.lastname: Buettner
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D020738:Leptin / Q000627:therapeutic use*; D008066:Lipolysis / Q000187:drug effects*
chemical_list: D007328:Insulin; D020738:Leptin