title: [Implants for drug substance delivery].
abstract: Implants for controlled drug delivery can be very helpful to improve the therapeutic efficacy of a medical treatment, and at the same time reduce the risk of toxic side effects. In this article, four different strategies are exemplarily presented: hybrid bone substitutes combining hydroxyapatite and chitosan hydrogels; vascular stents coated with a bio-inspired polymer; cochlear implants for local dexamethasone delivery; and in-situ forming implants for periodontitis treatment. But this is only a restricted selection, and numerous other approaches and applications based on implants releasing a drug (or a combination of drugs) exist. Compared to conventional implants or pharmaceutical dosage forms, they might offer decisive advantages.
authors.affiliation: Université de Lille, Inserm, U1008, CHU de Lille, Controlled Drug Delivery Systems and Biomaterials, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, F-59000 Lille, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Blanchemain
authors.affiliation: Université de Lille, Inserm, U1008, CHU de Lille, Controlled Drug Delivery Systems and Biomaterials, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, F-59000 Lille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Siepmann
authors.affiliation: Université de Lille, Inserm, U1008, CHU de Lille, Controlled Drug Delivery Systems and Biomaterials, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, F-59000 Lille, France.
authors.forename: Juergen
authors.initials: J
authors.lastname: Siepmann
mesh_terms: D000818:Animals; D003054:Cochlear Implants; D015921:Dental Implants; D016503:Drug Delivery Systems / Q000379:methods*; D004343:Drug Implants / Q000737:chemistry* / Q000627:therapeutic use*; D054855:Drug-Eluting Stents; D006083:Graft Occlusion, Vascular / Q000473:pathology; D006801:Humans; D010519:Periodontium; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D015921:Dental Implants; D004343:Drug Implants; D011108:Polymers