title: Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora.
abstract: Studies of the genome-sequenced, flutimide-producing coprophilous fungus Delitschia confertaspora (ATCC 74209), originally obtained from a sample of rock hyrax (Procavia capensis) dung collected in Namibia, led to the discovery of three new highly aromatic natural products named delicoferones A-B (1-2) and fimetarone B (3). The new benzophenone derivatives 1 and 2 have a somewhat unusual skeleton that incorporates three aromatic rings linked via two ketone carbonyl groups, while 3 contains a spiro[chroman-3,7'-isochromene]-4,6'(8'H) skeleton reported only once previously. The structures of these compounds were assigned mainly by analysis of 2D NMR and HRESITOFMS data.
authors.affiliation: Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
authors.forename: Dinith R
authors.initials: DR
authors.lastname: Jayanetti
authors.affiliation: Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , 1881 East Road, Houston, Texas 77054, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center , Houston, Texas 77054, United States.
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Bartholomeusz
authors.affiliation: Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , 1881 East Road, Houston, Texas 77054, United States.
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Bills
authors.affiliation: Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
authors.forename: James B
authors.identifier: 0000-0002-9261-7571
authors.initials: JB
authors.lastname: Gloer
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification*; D005658:Fungi / Q000737:chemistry*; D007043:Hyraxes; D015394:Molecular Structure; D009276:Namibia; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D001577:Benzophenones; D013141:Spiro Compounds; C000621347:delicoferone A; C000621348:delicoferone B; C576092:fimetarone A