title: Association of V249I and T280M variants of fractalkine receptor CX3CR1 with carotid intima-media thickness in a mexican population with type 2 diabetes.
abstract: OBJECTIVE
  To evaluate the association of the V249I and T280M variants of CX3CR1 fractalkine gene with carotid intima-media thickness in Mexican subjects with and without type 2 diabetes.
  
  
  METHODS
  We analyzed the V249I and T280M variants of the CX3CR1 receptor by TaqMan assays in 111 subjects with type 2 diabetes and 109 healthy controls. Hemoglobin A1c, glucose, and lipid profile were determined.
  
  
  RESULTS
  A significant increase in carotid intima-media thickness was observed in type 2 diabetes patients (0.979 ± 0.361 mm) compared to healthy controls (0.588 ± 0.175 mm). In subjects carrying the MM variant of the T280M polymorphism, hemoglobin A1c was higher (p = 0.008). Classic risk factors for atherosclerosis showed no differences between carriers of the T280M and V249I variants. Controls with the II249 genotype associated with carotid intima-media thickness (0.747 ± 0.192 mm; p = 0.041), and this difference remained significant even after adjusting factors such as age, gender, and body mass index (OR: 7.7; 95% CI: 1.269-47.31; p = 0.027).
  
  
  CONCLUSIONS
  V249I genotype of the fractalkine receptor showed a protector role in patients with type 2 diabetes. The T280M genotype is associated with increased carotid intima-media thickness in Mexican individuals with or without type 2 diabetes.
authors.affiliation: Unidad de Investigación Médica en Epidemiología Clínica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Rita A
authors.initials: RA
authors.lastname: Gómez-Díaz
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Gutiérrez
authors.affiliation: Servicio de Radiodiagnóstico de la UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Alicia
authors.initials: A
authors.lastname: Contreras-Rodriguez
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Adán
authors.initials: A
authors.lastname: Valladares-Salgado
authors.affiliation: Servicio de Radiodiagnóstico de la UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Janet
authors.initials: J
authors.lastname: Tanus-Hajj
authors.affiliation: Unidad de Investigación Médica en Epidemiología Clínica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Mondragón-González
authors.affiliation: Unidad de Investigación Médica en Epidemiología Clínica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Juan O
authors.initials: JO
authors.lastname: Talavera
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.|Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
authors.forename: María Aurora
authors.initials: MA
authors.lastname: Mejía-Benitez
authors.affiliation: Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: García-Mena
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Unidad de Investigación Médica en Epidemiología Clínica, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors.forename: Niels H
authors.initials: NH
authors.lastname: Wacher
mesh_terms: D000328:Adult; D000073883:CX3C Chemokine Receptor 1; D059168:Carotid Intima-Media Thickness; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging* / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D019707:Receptors, Chemokine / Q000235:genetics*
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine