title: Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death.
abstract: In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponins I and T (cTn-I and T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (p < 0.05). SCD cases showed significantly higher levels (p < 0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 h of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.
authors.affiliation: Biochemical and Nutrition Chemistry Area, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico.
authors.forename: Octavio
authors.initials: O
authors.lastname: Carvajal-Zarrabal
authors.affiliation: Biochemical and Nutrition Chemistry Area, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Hayward-Jones
authors.affiliation: Department of Chemical Engineering and Energy Sustainability of the Faculty of Engineering, University Malaysia Sarawak (UNIMAS), Kota Samarahan, Sarawak, Malaysia.
authors.forename: Cirilo
authors.initials: C
authors.lastname: Nolasco-Hipolito
authors.affiliation: Biological-Chemistry Area, Veracruz Institute of Technology, Calzada M.A. de Quevedo 2779, 91860, Veracruz, Ver, Mexico.
authors.forename: Dulce Ma
authors.initials: DM
authors.lastname: Barradas-Dermitz
authors.affiliation: Institute of Forensic Medicine, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico.
authors.forename: Ana Laura
authors.initials: AL
authors.lastname: Calderón-Garcidueñas
authors.affiliation: Institute of Forensic Medicine, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico.
authors.forename: Noé
authors.identifier: http://orcid.org/0000-0002-8279-841X
authors.initials: N
authors.lastname: López-Amador
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D052279:Creatine Kinase, MB Form / Q000097:blood*; D016757:Death, Sudden, Cardiac; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007118:Immunoassay; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D019210:Troponin I; D020107:Troponin T; D007770:L-Lactate Dehydrogenase; D052279:Creatine Kinase, MB Form
keywords: cardiac injury biomarkers; forensic pathology; forensic science; postmortem; sudden cardiac death; troponin I; troponin T