title: Neuroprotective potential ofIndigofera oblongifolialeaf methanolic extract against lead acetate-induced neurotoxicity.
abstract: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. This study investigated the possible neuroprotective role ofIndigofera oblongifolialeaf methanolic extract (IOLME) against lead-induced neurotoxicity. Rats were intraperitoneally injected with lead acetate, with or without IOLME (intragastric administration for 5 days), and the neuroprotective effect of IOLME was assessed by measuring the lead concentration, redox status (lipid peroxidation, nitric oxide and glutathione), enzymatic antioxidant activities (superoxide dismutase, catalase, glutathione peroxidase and reductase), PCR assays of apoptosis markers (Bax and Bcl-2) and histopathology of the brain. The increases in the lipid peroxidation, nitric oxide, and apoptosis, the decreases in the glutathione level and the activity of antioxidant enzymes, and the altered histology of the brain induced by lead acetate were mitigated in the brain of rats pre-treated with IOLME. These findings indicate that IOLME has beneficial effects and it mitigates lead acetate-induced neurotoxicityviaits antioxidant and anti-apoptotic activities.
authors.affiliation: Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Saleh
authors.initials: S
authors.lastname: Al-Quraishy
authors.affiliation: Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Dkhil
authors.affiliation: Department of Molecular Drug Evaluation, National Organization for Drug Control & Research (NODCAR), Giza, Egypt.
authors.forename: Shaimaa R
authors.initials: SR
authors.lastname: Ibrahim
authors.affiliation: Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
authors.forename: Ahmed E
authors.identifier: 0000-0002-2654-2591
authors.initials: AE
authors.lastname: Abdel Moneim
keywords: Indigofera oblongifolia; apoptosis; nerve regeneration; lead acetate; neural regeneration; neurotoxicity; oxidative stress