title: Multicomponent Assembly of the Kinesin Spindle Protein Inhibitor CPUYJ039 and Analogues as Antimitotic Agents.
abstract: The potent kinesin spindle protein inhibitor CPUYJ039 and a set of analogues were prepared by a target-oriented approach based on a Ugi reaction that uses 2-nitrophenyl isocyanides as key building blocks. The herein documented strategy provides straightforward and atom economical access to potent benzimidazole-based antimitotic agents by exploring the versatility and exploratory power of the Ugi reaction. The results of docking studies and biological activity evaluations of the benzimidazole compounds are also reported.
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Carbajales
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Shizuoka , Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Sawada
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova , Via Marzolo 5, 35131 Padova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Marzaro
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.|Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Avenida das Ciencias, s/n, Campus sur, Santiago de Compostela 15782, Spain.
authors.forename: Eddy
authors.identifier: 0000-0001-5571-2812
authors.initials: E
authors.lastname: Sotelo
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.
authors.forename: Luz
authors.initials: L
authors.lastname: Escalante
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sánchez-Díaz Marta
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Avenida das Ciencias, s/n, Campus sur, Santiago de Compostela 15782, Spain.
authors.forename: Xerardo
authors.initials: X
authors.lastname: García-Mera
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Shizuoka , Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Asai
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.|Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Avenida das Ciencias, s/n, Campus sur, Santiago de Compostela 15782, Spain.
authors.forename: Alberto
authors.identifier: 0000-0001-6514-3967
authors.initials: A
authors.lastname: Coelho
mesh_terms: D050256:Antimitotic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D006367:HeLa Cells; D006801:Humans; D016547:Kinesins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D062105:Molecular Docking Simulation
chemical_list: D050256:Antimitotic Agents; D001562:Benzimidazoles; C570061:CPUYJ039; C470243:KIF11 protein, human; D016547:Kinesins
keywords: CPUYJ039; Ugi reaction; antimitotic agent; kinesin spindle protein inhibitor