title: Vps13 and Cdc31/centrin: Puzzling partners in membrane traffic.
abstract: Yeast Vps13 is a member of a conserved protein family that includes human homologues associated with neurodegenerative and developmental disorders. In this issue, De et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606078) establish direct roles for Vps13 and its surprising binding partner, the calcium-binding centrin Cdc31, in trans-Golgi network (TGN) to endosome traffic and TGN homotypic fusion.
authors.affiliation: Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.
authors.forename: Margaret D
authors.initials: MD
authors.lastname: Myers
authors.affiliation: Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 gpayne@mednet.ucla.edu.
authors.forename: Gregory S
authors.identifier: 0000-0002-5267-5443
authors.initials: GS
authors.lastname: Payne
mesh_terms: D002135:Calcium-Binding Proteins; D006801:Humans; D021381:Protein Transport; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D021601:trans-Golgi Network
chemical_list: D002135:Calcium-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins