title: Diagnostic Method of Diabetes Based on Support Vector Machine and Tongue Images.
abstract: Objective. The purpose of this research is to develop a diagnostic method of diabetes based on standardized tongue image using support vector machine (SVM).Methods.Tongue images of 296 diabetic subjects and 531 nondiabetic subjects were collected by the TDA-1 digital tongue instrument. Tongue body and tongue coating were separated by the division-merging method and chrominance-threshold method. With extracted color and texture features of the tongue image as input variables, the diagnostic model of diabetes with SVM was trained. After optimizing the combination of SVM kernel parameters and input variables, the influences of the combinations on the model were analyzed.Results. After normalizing parameters of tongue images, the accuracy rate of diabetes predication was increased from 77.83% to 78.77%. The accuracy rate and area under curve (AUC) were not reduced after reducing the dimensions of tongue features with principal component analysis (PCA), while substantially saving the training time. During the training for selecting SVM parameters by genetic algorithm (GA), the accuracy rate of cross-validation was grown from 72% or so to 83.06%. Finally, we compare with several state-of-the-art algorithms, and experimental results show that our algorithm has the best predictive accuracy.Conclusions.The diagnostic method of diabetes on the basis of tongue images in Traditional Chinese Medicine (TCM) is of great value, indicating the feasibility of digitalized tongue diagnosis.
authors.affiliation: Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jianfeng
authors.identifier: 0000-0002-6176-5686
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jiatuo
authors.identifier: 0000-0002-1738-4245
authors.initials: J
authors.lastname: Xu
authors.affiliation: Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Qingguang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Tu
authors.affiliation: Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jingbin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Cui
mesh_terms: D003920:Diabetes Mellitus / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D012372:ROC Curve; D012680:Sensitivity and Specificity; D060388:Support Vector Machine; D014059:Tongue / Q000033:anatomy & histology*