title: Synthesis of ketones from biomass-derived feedstock.
abstract: Cyclohexanone and its derivatives are very important chemicals, which are currently produced mainly by oxidation of cyclohexane or alkylcyclohexane, hydrogenation of phenols, and alkylation of cyclohexanone. Here we report that bromide salt-modified Pd/C in H2O/CH2Cl2can efficiently catalyse the transformation of aromatic ethers, which can be derived from biomass, to cyclohexanone and its derivatives via hydrogenation and hydrolysis processes. The yield of cyclohexanone from anisole can reach 96%, and the yields of cyclohexanone derivatives produced from the aromatic ethers, which can be extracted from plants or derived from lignin, are also satisfactory. Detailed study shows that the Pd, bromide salt and H2O/CH2Cl2work cooperatively to promote the desired reaction and inhibit the side reaction. Thus high yields of desired products can be obtained. This work opens the way for production of ketones from aromatic ethers that can be derived from biomass.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Qinglei
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Minqiang
authors.initials: M
authors.lastname: Hou
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.|School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Liu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Song
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.|School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Buxing
authors.initials: B
authors.lastname: Han
mesh_terms: D000478:Alkylation; D018533:Biomass; D001965:Bromides / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003512:Cyclohexanones / Q000138:chemical synthesis*; D005025:Ethylene Dichlorides / Q000737:chemistry; D006865:Hydrogenation; D006868:Hydrolysis; D008031:Lignin / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001965:Bromides; D003512:Cyclohexanones; D005025:Ethylene Dichlorides; D014867:Water; D010165:Palladium; D002244:Carbon; D008031:Lignin