title: Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men.
abstract: In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(R,S)-[18F]-fluoro-6-thia-heptadecanoic acid (18FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues.
authors.affiliation: Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
authors.forename: Denis P
authors.initials: DP
authors.lastname: Blondin
authors.affiliation: Faculty of Health Sciences, University of Ottawa, 125 University Pvt. Ottawa, ON, Canada K1N 6N5.
authors.forename: Hans C
authors.initials: HC
authors.lastname: Tingelstad
authors.affiliation: Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
authors.forename: Christophe
authors.initials: C
authors.lastname: Noll
authors.affiliation: Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Frisch
authors.affiliation: Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.|Department of Nuclear Medicine and Radiobiology, Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
authors.forename: Serge
authors.initials: S
authors.lastname: Phoenix
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Guérin
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
authors.forename: Éric E
authors.initials: ÉE
authors.lastname: Turcotte
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725, chemin Sainte-Foy, Québec, QC, Canada G1V 4G5.
authors.forename: Denis
authors.initials: D
authors.lastname: Richard
authors.affiliation: Faculty of Health Sciences, University of Ottawa, 125 University Pvt. Ottawa, ON, Canada K1N 6N5.
authors.forename: François
authors.initials: F
authors.lastname: Haman
authors.affiliation: Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
authors.forename: André C
authors.initials: AC
authors.lastname: Carpentier
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism; D000328:Adult; D003080:Cold Temperature / Q000009:adverse effects; D004041:Dietary Fats / Q000097:blood / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D064368:Healthy Volunteers; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods; D019518:Postprandial Period / Q000502:physiology; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D022722:Thermogenesis / Q000502:physiology*; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18