Gold coated poly (ε-caprolactonediol) based polyurethane nanofibers for controlled release of temozolomide.
In the present study, the temozolomide (TMZ) loaded poly (ε-caprolactonediol) based polyurethane (PCL-Diol-b-PU) nanofibers were fabricated as local delivery systems against glioblastoma. The structure and morphology of nanofibers were characterized using FTIR and SEM analysis. The gold nanoparticles were coated on the nanofibers surface to enhance the efficacy of nanofibers for local chemotherapy of brain tumors. The effect of various ratios of DMF/THF solvents and solution concentration on the morphology and fiber diameter of PCL-Diol-b-PU nanofibers was investigated. The small burst release of TMZ with sustained TMZ release from both PCL-Diol-b-PU and gold-coated PCL-Diol-b-PU nanofibers were achieved over 30days. The Korsmayer-Peppas kinetic and Fickian diffusion models were used to describe the mechanism of TMZ release from nanofibers. The in vitro cell viability results revealed that the higher antitumor activity of synthesized nanofibers against glioblastoma cells compared with pristine TMZ. It was concluded that the prepared nanofibrous implants showed a higher potential in the local chemotherapy of brain tumors.
Department of Chemical Engineering, Amirkabir University of Technology, Tehran, Iran.
Mohammad
M
Irani
Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875/4413, Tehran, Iran. Electronic address: gsadeghi@aut.ac.ir.
Gity
G
Mir Mohamad Sadeghi
Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Ismaeil
I
Haririan
D002208:Caproates / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003692:Delayed-Action Preparations; D065546:Drug Liberation; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D000077204:Temozolomide
D002208:Caproates; D003692:Delayed-Action Preparations; D007783:Lactones; D011091:Polyesters; D011140:Polyurethanes; C121056:caprolactone; D006046:Gold; D003606:Dacarbazine; D000077204:Temozolomide
Controlled release; Gold; Nanofiber; Polyurethane; Temozolomide