Pleomorphic myxoid liposarcoma in an adolescent with Li-Fraumeni syndrome.
We present the case of a 15-year-old female with a right perineal mass that was found to be pleomorphic myxoid liposarcoma, a recently recognized, rare subtype of liposarcoma. The patient had a strong family history of malignancy and genetic screening revealed a pathogenic TP53 mutation consistent with Li-Fraumeni syndrome.
Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive Rm H3691, Stanford, CA, 94306, USA.
Tiffany J
TJ
Sinclair
Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA.
Chad M
CM
Thorson
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, USA.
Elysia
E
Alvarez
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive Rm L235, Stanford, CA, 94305, USA.
Serena
S
Tan
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, USA.
Sheri L
SL
Spunt
Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA. SChao@stanfordchildrens.org.
Stephanie D
SD
Chao
D000293:Adolescent; D005260:Female; D005833:Genital Neoplasms, Female / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000150:complications*; D018208:Liposarcoma, Myxoid / Q000150:complications* / Q000601:surgery*; D010502:Perineum / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
Hereditary cancer syndrome; Li–Fraumeni syndrome; Sarcoma; TP53 mutation