Gold-Catalyzed Direct Alkynylation of Azulenes.
A novel catalytic method for the direct C-H alkynylation of azulenes is developed. The gold catalyzed functionalization of this special carbacycle is achieved with hypervalent iodonium reagent TIPS-EBX under mild reaction conditions. With the aid of the developed procedure, several TIPS alkynylated azulene derivatives were synthesized bearing important functional groups for further functionalization.
MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Eötvös Loránd University , Institute of Chemistry Pázmány Péter stny. 1/A, Budapest, 1117, Hungary.
Anna
A
Székely
MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Eötvös Loránd University , Institute of Chemistry Pázmány Péter stny. 1/A, Budapest, 1117, Hungary.
Áron
Á
Péter
MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Eötvös Loránd University , Institute of Chemistry Pázmány Péter stny. 1/A, Budapest, 1117, Hungary.
Klára
K
Aradi
Eötvös Loránd University , Institute of Chemistry, Pázmány Péter stny. 1/A, Budapest, 1117, Hungary.
Gergely L
GL
Tolnai
MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Eötvös Loránd University , Institute of Chemistry Pázmány Péter stny. 1/A, Budapest, 1117, Hungary.
Zoltán
0000-0001-5525-3070
Z
Novák