Gold-Catalyzed Hydroarylation of N-Aryl Alkynamides for the Synthesis of 2-Quinolinones.
A mild method for the synthesis of 2-quinolinones via hydroarylation of N-aryl alkynamides is reported. While traditional methods have relied on the use of strong Brønsted or Lewis acids, this report describes the development of mild reaction conditions that yield 2-quinolinones in good to excellent yield using a commercially available gold catalyst. Substrates bearing a variety of functional groups are presented, with N-substitution proving to be key to the reactivity of several substrates.
Department of Chemistry, DePaul University , 1110 West Belden Avenue, Chicago, Illinois 60614, United States.
Taylor
T
Vacala
Department of Chemistry, DePaul University , 1110 West Belden Avenue, Chicago, Illinois 60614, United States.
Lauren P
LP
Bejcek
Department of Chemistry, DePaul University , 1110 West Belden Avenue, Chicago, Illinois 60614, United States.
Chloé G
CG
Williams
Department of Chemistry, DePaul University , 1110 West Belden Avenue, Chicago, Illinois 60614, United States.
Alexandra C
AC
Williamson
Department of Chemistry, DePaul University , 1110 West Belden Avenue, Chicago, Illinois 60614, United States.
Paul A
0000-0002-9176-3171
PA
Vadola