Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia.
Two new lignans, alashinols F and G (1 and 2), together with two known analogues (-)-secoisolariciresinol (3) and meso-secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute configurations were elucidated on the basis of experimental and calculated electronic circular dichroisms. The in vitro anti-inflammation and anti-hypoxia evaluations were also discussed.
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Xiao
X
Feng
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Guozhu
G
Su
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.|b Pharmaceutical School of Ningxia Medical , University Ningxia Engineering & Technology Research Center for Modernization of Hui Medicine , Yinchuan , People's Republic of China.
Yunyun
Y
Ye
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Ruifei
R
Zhang
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Xinyao
X
Yang
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Bingzhao
B
Du
c Beijing Institute of Traditional Chinese Medicine , Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University , Beijing , People's Republic of China.
Bing
B
Peng
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Pengfei
P
Tu
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Xingyun
X
Chai
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002072:Butylene Glycols / Q000302:isolation & purification; D000860:Hypoxia / Q000188:drug therapy; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D056785:Medicine, Mongolian Traditional; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D013057:Spectrum Analysis; D031662:Syringa / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D002072:Butylene Glycols; D017705:Lignans; C060283:secoisolariciresinol
Syringa pinnatifolia; alashinol F; alashinol G; calculated ECD; lignan