Evaluation of chemical composition and antiedematogenic activity of the essential oil ofHyptis martiusiiBenth.
Evaluations of the therapeutic potential of medicinal plants and their components have been the subject of many studies. Furthermore, the biological activities of various plant species have been reported in various pieces of literature.Hyptis martiusiiBenth (Lamiaceae), popularly known as "mad balm" is commonly found in the North, Southeast, and Northeast of Brazil. Its leaves are used ethnobiologically as antiulcerogenic, antimicrobial, antitumor and as insecticide. This study aimed to analyze the chemical composition of the essential oil ofH. martiusiiBenth (OEHM) by GC/MS as well as its possible topical activity as an antiedematogenic. This is verified by the models of ear edema induced by single (acute edema) and multiple (chronic edema) applications of croton oil topically, and systemically verified through the model of paw edema induced by carrageenan 1%. Doses of 50, 75 and 100 mg/kg OEHM were used in all tests. Chemical analysis of the oil revealed the 1,8-cineole (34.58%) andδ-carene (21:58%) as major components present in the essential oil. On the model of ear edema, acute and chronic OEHM in all the tested doses showed no significant antiedematogenic activity (p< 0.05). The systemic model of paw edema induced by carrageenin showed that a dose of 100 mg/kg effectively reduced swelling by 55.37% in the second hour evaluation when compared to the saline group. The anti-inflammatory systemic effect can give greater bioavailability of the components present in the essential oil and your interference in cytokines and leukotriene, thromboxane and prostaglandin biosynthesis. It is therefore concluded that OEHM presents systemic antiedematogenic activity but not topical activity at these doses.
Department of Biological Chemistry, Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri - URCA, Crato, CE, Brazil.
Andreza G R
AG
Barbosa
Department of Biological Chemistry, Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri - URCA, Crato, CE, Brazil.
Cicera D M
CD
Oliveira
Department of Biological Chemistry, Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri - URCA, Crato, CE, Brazil.
Luiz J
LJ
Lacerda-Neto
Department of Biological Chemistry, Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri - URCA, Crato, CE, Brazil.
Cinara S
CS
Vidal
Department of Biological Chemistry, Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri - URCA, Crato, CE, Brazil.
Rogério de A
RA
Saraiva
Department of Biological Chemistry, Laboratory of Research in Natural Product, Regional University of Cariri - URCA, Crato, CE, Brazil.
José G M
JG
da Costa
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Regional University of Cariri - URCA, Crato, CE, Brazil.
Henrique D M
HD
Coutinho
St George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
Hericka B F
HB
Galvao
Department of Biological Chemistry, Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri - URCA, Crato, CE, Brazil.
Irwin R A
IR
de Menezes
1,8 cineole; Antiedematogenic activity; Antiinflammatory effect; Essential oil; Hyptis martiusii; Natural products