Cortical maturation in children with cochlear implants: Correlation between electrophysiological and behavioral measurement.
Central auditory pathway maturation in children depends on auditory sensory stimulation. The objective of the present study was to monitor the cortical maturation of children with cochlear implants using electrophysiological and auditory skills measurements. The study was longitudinal and consisted of 30 subjects, 15 (8 girls and 7 boys) of whom had a cochlear implant, with a mean age at activation time of 36.4 months (minimum, 17 months; maximum, 66 months), and 15 of whom were normal-hearing children who were matched based on gender and chronological age. The auditory and speech skills of the children with cochlear implants were evaluated using GASP, IT-MAIS and MUSS measures. Both groups underwent electrophysiological evaluation using long-latency auditory evoked potentials. Each child was evaluated at three and nine months after cochlear implant activation, with the same time interval adopted for the hearing children. The results showed improvements in auditory and speech skills as measured by IT-MAIS and MUSS. Similarly, the long-latency auditory evoked potential evaluation revealed a decrease in P1 component latency; however, the latency remained significantly longer than that of the hearing children, even after nine months of cochlear implant use. It was observed that a shorter P1 latency corresponded to more evident development of auditory skills. Regarding auditory behavior, it was observed that children who could master the auditory skill of discrimination showed better results in other evaluations, both behavioral and electrophysiological, than those who had mastered only the speech-detection skill. Therefore, cochlear implant auditory stimulation facilitated auditory pathway maturation, which decreased the latency of the P1 component and advanced the development of auditory and speech skills. The analysis of the long-latency auditory evoked potentials revealed that the P1 component was an important biomarker of auditory development during the rehabilitation process.
Department of Physical, Speech and Occupational, FMUSP, São Paulo (SP), Brazil.
Liliane Aparecida Fagundes
LA
Silva
Department of Otorhinolaryngology, Clinical Hospital, FMUSP, São Paulo (SP), Brazil.
Maria Inês Vieira
MI
Couto
Department of Otorhinolaryngology, Clinical Hospital, FMUSP, São Paulo (SP), Brazil.
Fernanda C L
FC
Magliaro
Department of Otorhinolaryngology, Clinical Hospital, FMUSP, São Paulo (SP), Brazil.
Robinson Koji
RK
Tsuji
Department of Otorhinolaryngology, Clinical Hospital, FMUSP, São Paulo (SP), Brazil.
Ricardo Ferreira
RF
Bento
Department of Physical, Speech and Occupational, FMUSP, São Paulo (SP), Brazil.
Ana Claudia Martinho
AC
de Carvalho
Department of Physical, Speech and Occupational, FMUSP, São Paulo (SP), Brazil.
Carla Gentile
CG
Matas
D000161:Acoustic Stimulation; D001303:Auditory Cortex / Q000254:growth & development* / Q000503:physiopathology*; D001306:Auditory Pathways / Q000254:growth & development* / Q000503:physiopathology*; D016022:Case-Control Studies; D002675:Child, Preschool; D003054:Cochlear Implants / Q000523:psychology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006309:Hearing / Q000502:physiology; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011930:Reaction Time / Q000502:physiology; D013060:Speech / Q000502:physiology