Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations.
We present clinical features and substantia nigra morphology for two brothers with Parkinson's disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.
Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, Australia; School of Social Sciences and Psychology, Western Sydney University, Horsley Road & Bullecourt Road, Milperra, NSW 2214, Australia.
Julie M
JM
Hall
Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, Australia.
Matthew J
MJ
Georgiades
Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, Australia.
Deborah A
DA
Hammond
Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, Australia.
Xiaoting
X
Feng
School of Social Sciences and Psychology, Western Sydney University, Horsley Road & Bullecourt Road, Milperra, NSW 2214, Australia; Marcs Institute for Brain and Behaviour, Western Sydney University, Horsley Road & Bullecourt Road, Milperra, NSW 2214, Australia.
Ahmed A
AA
Moustafa
Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Church St, Camperdown, NSW, Australia.
Simon J G
0000-0001-6460-5699
SJ
Lewis
School of Pharmacy and Medical Sciences and Sansom Institute for Health Research, University of South Australia, P.O. Box 2471, Adelaide, SA 5001, Australia.
Gabrielle
G
Todd