Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics.
Magnetic nanoparticles (MNPs) have been used in many diagnostic and therapeutic biomedical applications over the past few decades to enhance imaging contrast, steer drugs to targets, and treat tumors via hyperthermia. Optical coherence tomography (OCT) is an optical biomedical imaging modality that relies on the detection of backscattered light to generate high-resolution cross-sectional images of biological tissue. MNPs have been utilized as imaging contrast and perturbative mechanical agents in OCT in techniques called magnetomotive OCT (MM-OCT) and magnetomotive elastography (MM-OCE), respectively. MNPs have also been independently used for magnetic hyperthermia treatments, enabling therapeutic functions such as killing tumor cells. It is well known that the localized tissue heating during hyperthermia treatments result in a change in the biomechanical properties of the tissue. Therefore, we propose a novel dosimetric technique for hyperthermia treatment based on the viscoelasticity change detected by MM-OCE, further enabling the theranostic function of MNPs. In this paper, we first review the basic principles and applications of MM-OCT, MM-OCE, and magnetic hyperthermia, and present new preliminary results supporting the concept of MM-OCE-based hyperthermia dosimetry.
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, and the Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( phuang16@illinois.edu ).
Pin-Chieh
PC
Huang
Biophotonics Imaging Laboratory and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( pande@illinois.edu ).
Paritosh
P
Pande
Biophotonics Imaging Laboratory and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( aahmad5@illinois.edu ).
Adeel
A
Ahmad
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, and the Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( marinam@illinois.edu ).
Marina
M
Marjanovic
Biophotonics Imaging Laboratory and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( dspillm2@illinois.edu ).
Darold R
DR
Spillman
Biophotonics Imaging Laboratory and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( bodintso@illinois.edu ).
Boris
B
Odintsov
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, and the Departments of Electrical and Computer Engineering, Bioengineering, and Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA (phone: 217-333-8598; fax: 217-333-5833; boppart@illinois.edu ).
Stephen A
SA
Boppart
Magnetomotive nanoparticles; biomechanics; magnetic hyperthermia; optical coherence elastography; optical coherence tomography; theranostic; thermotherapy