Immunomodulatory Study of Different Solvent Extract of Elephantopus scaber Linn.
The aim and objective of present study is that to provide a scientific evidence for the immunomodulatory potential ofElephantopus scaberin vivo.The immunomodulatory activity was performed in petroleum ether, solvent ether, methanol and aqueous extract of aerial part and root ofE. scaberby using models such as delayed type hypersensitivity, humoral antibody response to SRBC and carbon clearance test for phagocytic activity in Wistar rat. The observation and results of present study suggested that among the total 8 extract, only the petroleum ether and solvent ether aerial part extract ofE. scabersignificantly decreased in delayed type hypersensitivity (DTH), humoral antibody (HA) titre and phagocytic index thereby indicating significant immunosuppressant activity in experimental animals.
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, India.
Sachin M
SM
Hiradeve
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, India.
Vinod D
VD
Rangari
D000473:Alkanes / Q000737:chemistry; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004195:Disease Models, Animal; D004987:Ethers / Q000737:chemistry; D006968:Hypersensitivity, Delayed / Q000188:drug therapy*; D056747:Immunomodulation; D008297:Male; D000432:Methanol / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry*
D000473:Alkanes; D004987:Ethers; D010936:Plant Extracts; D012997:Solvents; C004544:naphtha; D000432:Methanol