Natural Product Synthesis via Palladium-Catalyzed Carbonylation.
Carbon monoxide is an important one-carbon source and can be incorporated in complex molecules via various transition-metal-catalyzed carbonylation reactions. In particular, palladium-catalyzed carbonylation reactions have found broad application in total synthesis of natural products. Examples are presented in this Synopsis to highlight recent progress in this area, including our own work in macrolide and spirocyclic molecule synthesis. In these selected cases, carbon monoxide functions as a one-carbon linchpin to facilitate building structural complexity and improving synthetic efficiency.
Department of Chemistry and Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.
Yu
Y
Bai
Department of Chemistry and Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.
Dexter C
DC
Davis
Department of Chemistry and Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.
Mingji
0000-0001-7956-6426
M
Dai
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D001688:Biological Products; D007659:Ketones; D010165:Palladium