Antipsychotic Treatment and Tobacco Craving in People With Schizophrenia.
OBJECTIVE
Nicotine dependence is high in schizophrenia, and craving is known to impact relapse during quit attempts.


METHODS
We compared tobacco craving in smokers with schizophrenia treated with different antipsychotics.


RESULTS
Mean craving scores were lowest in participants receiving first-generation antipsychotics, although these differences were not statistically significant. Craving with clozapine was not lower than with other antipsychotics.


CONCLUSIONS
Further research is needed to determine whether differences in craving exist between antipsychotic classes.
a Maryland Psychiatric Research Center, University of Maryland School of Medicine , Baltimore , MD , USA.
Heidi J
HJ
Wehring
b National Institute of Health, National Institute on Drug Abuse, Intramural Research Program , Baltimore , MD , USA.
Stephen J
SJ
Heishman
a Maryland Psychiatric Research Center, University of Maryland School of Medicine , Baltimore , MD , USA.
Robert P
RP
McMahon
a Maryland Psychiatric Research Center, University of Maryland School of Medicine , Baltimore , MD , USA.
Fang
F
Liu
a Maryland Psychiatric Research Center, University of Maryland School of Medicine , Baltimore , MD , USA.
Stephanie
S
Feldman
a Maryland Psychiatric Research Center, University of Maryland School of Medicine , Baltimore , MD , USA.
Heather
H
Raley
a Maryland Psychiatric Research Center, University of Maryland School of Medicine , Baltimore , MD , USA.
Elaine
E
Weiner
a Maryland Psychiatric Research Center, University of Maryland School of Medicine , Baltimore , MD , USA.
Deanna L
DL
Kelly
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use; D066249:Craving / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D018967:Risperidone / Q000627:therapeutic use; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D012907:Smoking / Q000523:psychology*; D014029:Tobacco Use Disorder / Q000150:complications / Q000523:psychology*
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D003024:Clozapine; D018967:Risperidone; D000077152:Olanzapine
Tobacco; antipsychotic; craving; schizophrenia