SATB1 plays an oncogenic role in esophageal cancer by up-regulation of FN1 and PDGFRB.
Esophageal cancer is a highly aggressive malignancy with very poor overall prognosis. Given the strong clinical relevance of SATB1 in esophagus cancer and other cancers suggested by previous studies, the exact function of SATB1 in esophagus cancer development is still unknown. Here we showed that the knockdown of SATB1 in esophageal cancer cell lines diminished the cell proliferation, survival and invasion. Whole genome transcriptome analysis of SATB1 knockdown cells revealed the different gene expression profiles between TE-1 cells and MDA-MB-231 cells. Network analysis and functional experiments further identified FN1 and PDGFRB to be key downstream genes regulated by SATB1 in esophageal cancer cells. Importantly, FN1 and PDGFRB were found to be highly expressed in human esophageal cancer. In summary, we provided the first molecular evidence that SATB1 played an oncogenic role in esophageal cancer by up-regulation of FN1 and PDGFRB.
Department of Biology, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.|Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.|State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, P.R. China.
Guiqin
G
Song
Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.|Biotherapy Center, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.
Kang
K
Liu
Department of Biology, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.|Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.
Xiaolin
X
Yang
Department of Biology, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
Bo
B
Mu
Department of Biology, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
Junbao
J
Yang
Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.|Biotherapy Center, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.
Lang
L
He
Biotherapy Center, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.
Xin
X
Hu
Clinical College of North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
Qiujiang
Q
Li
Clinical College of North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
Yunxia
Y
Zhao
Department of Biology, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
Xiaoming
X
Cai
Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.|Biotherapy Center, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China.
Gang
G
Feng
D063646:Carcinogenesis / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics*; D002470:Cell Survival / Q000235:genetics; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D005353:Fibronectins / Q000096:biosynthesis*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000096:biosynthesis*; D015533:Transcriptional Activation; D015854:Up-Regulation
C067625:FN1 protein, human; D005353:Fibronectins; D036961:Matrix Attachment Region Binding Proteins; D034741:RNA, Small Interfering; C076189:SATB1 protein, human; C000605860:PDGFRB protein, human; D020797:Receptor, Platelet-Derived Growth Factor beta
FN1; PDGFRB; SATB1; esophageal cancer