Elevated transglutaminase-2 expression in the epidermis of psoriatic skin and its role in the skin lesion development.
Psoriasis, an inflammatory skin disease triggered by the immune system, presents keratinocyte hyperproliferation, differentiation and angiogenesis. The role of transglutaminase-2 (TG2) in psoriasis has not been fully established yet. In this retrospective, non-randomized and non-blinded study, skin biopsies were collected from 37 psoriatic patients and immunohistochemical staining was performed. TG2 staining was positive in all 37 samples, among which 32 were strong and five weak. The localization of TG2 staining was present in the epidermis and spreading from basal layer to stratum granulosum in decreasing staining intensity. However, TG2 was also expressed in the basal layer in the non-lesional site of psoriasis and the skin of healthy people. The presence of TG2 was not associated with disease duration, stage of disease and subtype of psoriasis. Overexpression of TG2 seems to be an important role in psoriatic development.
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital (TSMH), Pingtung, Taiwan.|Department of Beauty Science, Meiho University, Pingtung, Taiwan.
Ching-Chyuan
CC
Su
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital (TSMH), Pingtung, Taiwan.|Department of Beauty Science, Meiho University, Pingtung, Taiwan.
Tzu-Rong
TR
Su
Research Assistant Center, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan.
Ji-Ching
JC
Lai
Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
Gregory-J
GJ
Tsay
Division of Immunology and Rheumatology, Department of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
Hung-Ke
HK
Lin
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004817:Epidermis / Q000201:enzymology; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011565:Psoriasis / Q000201:enzymology* / Q000209:etiology; D012189:Retrospective Studies; D011503:Transglutaminases / Q000378:metabolism*; D055815:Young Adult
D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins
immune system; immunohistochemical staining; psoriasis; skin; transglutaminase-2