Boron neutron capture therapy for malignant melanoma: first clinical case report in China.
A phase I/II clinical trial for treating malignant melanoma by boron neutron capture therapy (BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator (IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography (PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT, indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals.
Department of Nuclear Medicine, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Zhong
Z
Yong
Department of Oncology, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Zewen
Z
Song
China Zhongyuan Engineering Corporation, Beijing 100191, China.
Yongmao
Y
Zhou
Department of Nuclear Medicine, China Nuclear Industry Beijing 401 Hospital, Beijing 102413, China.
Tong
T
Liu
Department of Nuclear Medicine, China Nuclear Industry Beijing 401 Hospital, Beijing 102413, China.
Zizhu
Z
Zhang
Medical Experimental Center, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Yanzhong
Y
Zhao
Department of Nuclear Medicine, China Nuclear Industry Beijing 401 Hospital, Beijing 102413, China.
Yang
Y
Chen
Department of Nuclear Medicine, China Nuclear Industry Beijing 401 Hospital, Beijing 102413, China.
Congjun
C
Jin
Department of Dermatology, Xiangya Hospital of Central South University, Changsha 410008, China.
Xiang
X
Chen
Department of Dermatology, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Jianyun
J
Lu
Department of Anesthesiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Rui
R
Han
Department of General Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Pengzhou
P
Li
Department of General Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Xulong
X
Sun
Department of General Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Guohui
G
Wang
Department of Nuclear Medicine, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Guangqing
G
Shi
Department of General Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Shaihong
S
Zhu
In-hospital neutron irradiator; boron neutron capture therapy; malignant melanoma