Activity of chemokines in prostate and renal tumors and their potential role as future therapeutic targets.
Chemokines are a class of low-molecular-weight proteins that induce chemotaxis and are implicated in the modulation of angiogenesis. The imbalance among angiogenic and antiangiogenic chemokines can promote the development of several conditions, including chronic inflammation, dysplastic transformation and cancer. In this review, we describe the activity and clinical significance of chemokines in prostate and renal tumors and provide an update on ongoing studies in this setting.
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Alessia
A
Cimadamore
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Marina
M
Scarpelli
Department of Specialist Clinical & Odontostomatological Sciences, Università Politecnica delle Marche, Ancona, Italy.
Francesco
F
Piva
Division of Oncology, S Orsola-Malpighi Hospital, Bologna, Italy.
Francesco
F
Massari
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Silvia
S
Gasparrini
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Andrea
A
Doria
Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Liang
L
Cheng
Department of Surgery & Pathology, Faculty of Medicine, Cordoba University Medical School, Cordoba, Spain.|Champalimaud Clinical Center, Lisbon, Portugal.
Antonio
A
Lopez-Beltran
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Rodolfo
R
Montironi
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007167:Immunotherapy; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D058990:Molecular Targeted Therapy; D009389:Neovascularization, Pathologic / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019707:Receptors, Chemokine / Q000378:metabolism; D015398:Signal Transduction
D000970:Antineoplastic Agents; D018925:Chemokines; D019707:Receptors, Chemokine
angiogenesis; chemokines; prostate cancer; renal cancer