Three new anthraquinones from the twigs of Cassia fistula and their bioactivities.
Three previously unreported anthraquinones, fistulaquinones A-C (1-3), together with three known ones (4-6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1-6 exhibited moderate cytotoxicity with IC50values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|b Technology Center, China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Min
M
Zhou
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Huan-Huan
HH
Xing
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Yan
Y
Yang
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Yue-De
YD
Wang
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Kun
K
Zhou
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Wei
W
Dong
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Gan-Peng
GP
Li
b Technology Center, China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Wei-Yao
WY
Hu
b Technology Center, China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Qiang
Q
Liu
b Technology Center, China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Xue-Mei
XM
Li
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c School of Ethnic Medicine , Yunnan Minzu University , Kunming 650031 , China.
Qiu-Fen
QF
Hu
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D003562:Cytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000880:Anthraquinones; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; C000625035:fistulaquinone A; C000625036:fistulaquinone B; C000625037:fistulaquinone C; C000594254:ningnanmycin; D003562:Cytidine; D017239:Paclitaxel
Anthraquinones; Cassia fistula; anti-tobacco mosaic virus activity; cytotoxicity