Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array.
Noninvasive measurement of the distribution and oxygenation state of hemoglobin (Hb) inside the tissue is strongly required to analyze the tumor-associated vasculatures. We developed a photoacoustic imaging (PAI) system with a hemispherical-shaped detector array (HDA). Here, we show that PAI system with HDA revealed finer vasculature, more detailed blood-vessel branching structures, and more detailed morphological vessel characteristics compared with MRI by the use of breast shape deformation of MRI to PAI and their fused image. Morphologically abnormal peritumoral blood vessel features, including centripetal photoacoustic signals and disruption or narrowing of vessel signals, were observed and intratumoral signals were detected by PAI in breast cancer tissues as a result of the clinical study of 22 malignant cases. Interestingly, it was also possible to analyze anticancer treatment-driven changes in vascular morphological features and function, such as improvement of intratumoral blood perfusion and relevant changes in intravascular hemoglobin saturation of oxygen. This clinical study indicated that PAI appears to be a promising tool for noninvasive analysis of human blood vessels and may contribute to improve cancer diagnosis.
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
M
M
Toi
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.|Medical Imaging System Development Center, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
Y
Y
Asao
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
Y
Y
Matsumoto
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
H
H
Sekiguchi
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
A
A
Yoshikawa
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
M
M
Takada
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
M
M
Kataoka
Medical Imaging System Development Center, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
T
T
Endo
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
N
N
Kawaguchi-Sakita
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
M
M
Kawashima
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
E
E
Fakhrejahani
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
S
S
Kanao
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
I
I
Yamaga
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
Y
Y
Nakayama
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
M
M
Tokiwa
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
M
M
Torii
Medical Imaging System Development Center, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
T
T
Yagi
Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
T
T
Sakurai
Medical Imaging System Development Center, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
K
K
Togashi
Department of Human Health Science, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho Sakyo-ku, Kyoto 606-8507, Japan.
T
T
Shiina
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001808:Blood Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D001940:Breast / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods*; D055815:Young Adult