Aquaporin-2 membrane targeting: still a conundrum.
The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.
Department of Biomedical Sciences, Faculty of Health Sciences, Copenhagen University, Copenhagen, Denmark; etbo@sund.ku.dk.|Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; and.
Emma T B
ET
Olesen
Department of Biomedicine, InterPrET Center, Health, Aarhus University, Aarhus, Denmark.
Robert A
RA
Fenton
D000818:Animals; D051399:Aquaporin 2 / Q000378:metabolism*; D001127:Arginine Vasopressin / Q000378:metabolism; D001834:Body Water / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D021381:Protein Transport; D017483:Receptors, Vasopressin / Q000378:metabolism; D015290:Second Messenger Systems; D014882:Water-Electrolyte Balance
D051399:Aquaporin 2; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D000242:Cyclic AMP
7-transmembrane receptors; aquaporin; cAMP; cell signaling; vasopressin