Ultrasound imaging velocimetry with interleaved images for improved pulsatile arterial flow measurements: a new correction method, experimental and in vivo validation.
Blood velocity measurements are important in physiological science and clinical diagnosis. Doppler ultrasound is the most commonly used method but can only measure one velocity component. Ultrasound imaging velocimetry (UIV) is a promising technique capable of measuring two velocity components; however, there is a limit on the maximum velocity that can be measured with conventional hardware which results from the way images are acquired by sweeping the ultrasound beam across the field of view. Interleaved UIV is an extension of UIV in which two image frames are acquired concurrently, allowing the effective interframe separation time to be reduced and therefore increasing the maximum velocity that can be measured. The sweeping of the ultrasound beam across the image results in a systematic error which must be corrected: in this work, we derived and implemented a new velocity correction method which accounts for acceleration of the scatterers. We then, for the first time, assessed the performance of interleaved UIV for measuring pulsatile arterial velocities by measuring flows in phantoms and in vivo and comparing the results with spectral Doppler ultrasound and transit-time flow probe data. The velocity and flow rate in the phantom agreed within 5-10% of peak velocity, and 2-9% of peak flow, respectively, and in vivo the velocity difference was 9% of peak velocity. The maximum velocity measured was 1.8 m s-1, the highest velocity reported with UIV. This will allow flows in diseased arteries to be investigated and so has the potential to increase diagnostic accuracy and enable new vascular research.
Department of Mechanical Engineering, University of Bath, Bath BA2 7AY, UK k.h.fraser@bath.ac.uk.
Katharine H
0000-0002-7828-1354
KH
Fraser
Laboratory for Aero and Hydrodynamics, Delft University of Technology, Delft, The Netherlands.
Christian
C
Poelma
School of Environment and Energy, Southeast University, Nanjing, People's Republic of China.
Bin
B
Zhou
Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Eleni
E
Bazigou
Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Meng-Xing
MX
Tang
Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Peter D
PD
Weinberg
D000818:Animals; D008297:Male; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D011817:Rabbits; D018608:Ultrasonography, Doppler / Q000379:methods*
atherosclerosis; blood flow; echo-PIV; haemodynamics; particle image velocimetry; ultrasound