Desulfurative Chlorination of Alkyl Phenyl Sulfides.
The chlorination of readily available secondary and tertiary alkyl phenyl sulfides using (dichloroiodo)benzene (PhICl2) is reported. This mild and rapid nucleophilic chlorination is extended to sulfa-Michael derived sulfides, affording elimination-sensitive β-chloro carbonyl and nitro compounds in good yields. The chlorination of enantioenriched benzylic sulfides to the corresponding inverted chlorides proceeds with high stereospecificity, thus providing a formal entry into enantioenriched chloro-Michael adducts. A mechanism implying the formation of a dichloro-λ4-sulfurane intermediate is proposed.
Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland , 123 St. Stephen's Green, Dublin 2, Ireland.
Daniele
D
Canestrari
Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland , 123 St. Stephen's Green, Dublin 2, Ireland.
Stefano
S
Lancianesi
Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland , 123 St. Stephen's Green, Dublin 2, Ireland.
Eider
E
Badiola
Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland , 123 St. Stephen's Green, Dublin 2, Ireland.
Chiara
C
Strinna
Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland , 123 St. Stephen's Green, Dublin 2, Ireland.
Hasim
0000-0003-1386-3641
H
Ibrahim
Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland , 123 St. Stephen's Green, Dublin 2, Ireland.
Mauro F A
0000-0001-9072-3648
MF
Adamo