Chitosan coated tungsten trioxide nanoparticles as a contrast agent for X-ray computed tomography.
Recent advances have shown that inorganic nanoparticles (NPs) based on heavy elements are highly appropriate for X-ray computed tomography (CT). In this contribution, tungsten trioxide NPs are prepared by the electrical arc discharge (EAD) method in DI water. The effect of chitosan (CTS) and glutaraldehyde (GTA) as coating and cross-linking agent, respectively, on the hydrodynamic size and zeta potential of prepared tungsten trioxide NPs is investigated. It is found that zeta potential increases by increasing the amounts of CTS. Meanwhile, by increasing the volume of glutaraldehyde (GTA), the final particle size increases whereas the zeta potential deceases. Chitosan coated tungsten trioxide demonstrated no significant cytotoxicity at concentration up to 5mg/mL after 24h. Finally, the X-ray attenuation of prepared chitosan coated tungsten trioxide NPs are higher than Iohexol as the commercially available iodinated contrasting agent at the same concentrations.
Department of Materials Engineering, Tarbiat Modares University, P.O. Box 14115-143, Tehran, Iran.
Mehdi
M
Firouzi
Department of Materials Engineering, Tarbiat Modares University, P.O. Box 14115-143, Tehran, Iran.
Reza
R
Poursalehi
Department of Materials Engineering, Tarbiat Modares University, P.O. Box 14115-143, Tehran, Iran. Electronic address: Hamid.delavari@modares.ac.ir.
Hamid
H
Delavari H
Department of Laboratory Science, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fakhredin
F
Saba
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad A
MA
Oghabian
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D053758:Nanoparticles; D010087:Oxides / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D014057:Tomography, X-Ray Computed; D014414:Tungsten / Q000737:chemistry* / Q000633:toxicity
D003287:Contrast Media; D010087:Oxides; D048271:Chitosan; C511604:tungsten oxide; D014414:Tungsten
Central composite design; Chitosan; Contrast agent; Micro-CT; Nanoparticles; Surface response; Tungsten trioxide; X-ray imaging