Viral Pneumonia in Patients with Hematologic Malignancy or Hematopoietic Stem Cell Transplantation.
Viral pneumonias in patients with hematologic malignancies and recipients of hematopoietic stem cell transplantation cause significant morbidity and mortality. Advances in diagnostic techniques have enabled rapid identification of respiratory viral pathogens from upper and lower respiratory tract samples. Lymphopenia, myeloablative and T-cell depleting chemotherapy, graft-versus-host disease, and other factors increase the risk of developing life-threatening viral pneumonia. Chest imaging is often nonspecific but may aid in diagnoses. Bronchoscopy with bronchoalveolar lavage is recommended in those at high risk for viral pneumonia who have new infiltrates on chest imaging.
Division of Internal Medicine, Department of Pulmonary, Critical Care and Sleep Medicine, The University of Texas Health Sciences Center, 6431 Fannin Street, MSB 1.434, Houston, TX 77030, USA. Electronic address: erik.vakil@uth.tmc.edu.
Erik
E
Vakil
Division of Internal Medicine, Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1100, Houston, TX 77030, USA. Electronic address: seevans@mdanderson.org.
Scott E
SE
Evans
D019337:Hematologic Neoplasms / Q000150:complications* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D011024:Pneumonia, Viral / Q000209:etiology* / Q000473:pathology; D019172:Transplantation Conditioning / Q000009:adverse effects*
Hematologic malignancy; Immunocompromised host pneumonia; Stem cell transplant; Viral pneumonia