Teriparatide treatment of femoral fracture nonunion that autogenous bone grafting failed to heal: a case report.
OBJECTIVE
Management of fracture nonunion is challenging as another surgical intervention for the patient is often a necessity, which has a huge impact on both quality of life and economic burden of the patient. Thus, a less aggressive and better accepted treatment for nonunion is required.


METHODS
We gave teriparatide to a 45-year-old man with femoral fracture nonunion 1 year after he underwent surgery with autogenous bone grafting that failed to heal his initial nonunion. Successful union was obtained after once-daily administration of teriparatide for 9 months.


RESULTS
Our case showed teriparatide could successfully treat a femoral fracture nonunion that autogenous bone grafting failed to heal.


CONCLUSIONS
Teriparatide may provide an alternative treatment for fracture nonunion.
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China.
Wei
W
Yu
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China. xiaodongguo@hust.edu.cn.
Xiaodong
X
Guo
D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods; D005264:Femoral Fractures / Q000150:complications / Q000601:surgery; D017102:Fracture Healing / Q000187:drug effects*; D005599:Fractures, Ununited / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D019379:Teriparatide / Q000008:administration & dosage*; D016896:Treatment Outcome
D050071:Bone Density Conservation Agents; D019379:Teriparatide
Femoral fracture; Fracture healing; Nonunion; Teriparatide