Characterization of micro-resonator based on enhanced metal insulator semiconductor capacitor for glucose recognition.
We present a concept for the characterization of micro-fabricated based resonator incorporating air-bridge metal-insulator-semiconductor (MIS) capacitor to continuously monitor an individual's state of glucose levels based on frequency variation. The investigation revealed that, the micro-resonator based on MIS capacitor holds considerable promise for implementation and recognition as a glucose sensor for human serum. The discrepancy in complex permittivity as a result of enhanced capacitor was achieved for the detection and determination of random glucose concentration levels using a unique variation of capacitor that indeed results in an adequate variation of the resonance frequency. Moreover, the design and development of micro-resonator with enhanced MIS capacitor generate a resolution of 112.38 × 10-3pF/mg/dl, minimum detectable glucose level of 7.45mg/dl, and a limit of quantification of 22.58mg/dl. Additionally, this unique approach offers long-term reliability for mediator-free glucose sensing with a relative standard deviation of less than 0.5%.
Department of Electronic Engineering, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea. Electronic address: aperioraj@gmail.com.
Rajendra
R
Dhakal
Department of Electronic Engineering, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
E S
ES
Kim
Department of Biochemistry and Molecular Biology, Kyung-Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Yong-Hwa
YH
Jo
Department of Biochemistry and Molecular Biology, Kyung-Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Sung-Soo
SS
Kim
Department of Electronic Engineering, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea. Electronic address: nykim@kw.ac.kr.
Nam-Young
NY
Kim
D001774:Blood Chemical Analysis / Q000295:instrumentation; D001786:Blood Glucose / Q000032:analysis*; D025802:Electric Capacitance; D008670:Metals; D055616:Microtechnology / Q000295:instrumentation*; D011846:Radio Waves; D012666:Semiconductors
D001786:Blood Glucose; D008670:Metals
Glucose sensor; Integrated passive device; Metal-insulator-semiconductor; Microwave resonator; Permittivity