The effect of captopril on the performance of the control strategies of BJUT-II VAD.
BACKGROUND
With the development of left ventricular assist device (LVAD), the long-term support has been paid more attention by various researchers. According to previous researches, the combination of LVAD and pharmacological therapy can significantly improve the heart rate recovery and survival rate of patient. However, the effect of pharmacological therapy on the cardiovascular hemodynamic states with LVAD support is still unclear.


METHODS
In this study, pharmacokinetic model of captopril is established to describe the relationship between plasma-drug concentration and time. Then, combination model, consisting of pharmacokinetic model of captopril and lumped parameter model of cardiovascular system with BJUT-II VAD support, is established to mimic the effect of pharmacological therapy on cardiovascular hemodynamics. BAI control strategy and HR control strategy for BJUT-II VAD are chosen to evaluate their performance by the combination model.


RESULTS
The simulation results demonstrate that the concentration of captopril could affect the pressure and heart rate by changing the peripheral resistance, and then affect the performance of BJUT-II VAD in a short duration. Under the regulation of control strategies of BJUT-II VAD, the hemodynamic states of cardiovascular system returned to the standard value in 10 s.


CONCLUSIONS
This study could provide useful information about how to design coupled strategy of LVAD support and pharmacological therapy.
School of Life Science and BioEngineering, Beijing University of Technology, Beijing, 100124, People's Republic of China.
Kaiyun
K
Gu
School of Life Science and BioEngineering, Beijing University of Technology, Beijing, 100124, People's Republic of China.
Bin
B
Gao
School of Life Science and BioEngineering, Beijing University of Technology, Beijing, 100124, People's Republic of China. changyu@bjut.edu.cn.
Yu
Y
Chang
School of Life Science and BioEngineering, Beijing University of Technology, Beijing, 100124, People's Republic of China.
Yi
Y
Zeng
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use; D002216:Captopril / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D003198:Computer Simulation; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D013997:Time Factors; D016277:Ventricular Function, Left
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril