Association between Obesity and Serum 25(OH)D Concentrations in Older Mexican Adults.
BACKGROUND
Vitamin D is essential for maintaining bone mineralization and calcium homeostasis, and prevents falls and fractures in older adults. Mexico is undergoing an epidemiologic and demographic transition with increasing obesity rates. The study's aim was to determine the association of obesity with serum 25-hydroxyvitamin D [25(OH)D] concentrations in older Mexican adults.


METHODS
Data from 1772 Mexicans, aged ≥50 years, enrolled in a sub-sample of the 3rd wave of the Mexican Health and Aging Study, were included. Serum 25(OH)D concentrations were used to define vitamin D status, and were categorized into tertiles. Body mass index measures were used to categorize older adults into under/normal weight, overweight, and obese groups. Multinomial logistic regression models were used to assess the relationship, adjusting for potential confounders.


RESULTS
Approximately 40% and 37% of older Mexican adults were either overweight or obese, respectively. Compared to under/normal weight older Mexicans, obese adults were 1.78 times (95% Confidence Interval (CI) 1.27-2.48) and 1.94 times (95% CI 1.40-2.68) more associated with the first and second tertile concentrations of serum 25(OH)D, respectively. Overweight adults were 1.52 times (95% CI 1.12-2.06) more associated with the second tertile of serum 25(OH)D concentration than under/normal weight adults.


CONCLUSIONS
Overweight/Obesity was found to be significantly associated with low concentrations of serum 25(OH) in older Mexican adults.
Metabolism Unit, Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA. virodoyi@utmb.edu.|Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. virodoyi@utmb.edu.
Victoria G
VG
Rontoyanni
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. jaqcontr@utmb.edu.
Jaqueline C
JC
Avila
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. sakaul@utmb.edu.
Sapna
S
Kaul
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. rewong@utmb.edu.
Rebeca
R
Wong
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. spveeran@UTMB.EDU.
Sreenivas P
SP
Veeranki
D000368:Aged; D000375:Aging; D015992:Body Mass Index; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*; D055105:Waist Circumference
D014807:Vitamin D; C104450:25-hydroxyvitamin D
Body Mass Index (BMI); Mexican Health and Aging Study (MHAS); obesity; older Mexican adult; serum 25(OH)D; vitamin D