Cohort profile for the Nurture Observational Study examining associations of multiple caregivers on infant growth in the Southeastern USA.
Childcare has been associated with obesity in children in cross-sectional and longitudinal studies, although some observed no association. Few studies have focused on care during infancy, a period when children may be especially vulnerable.



The Nurture Study is an observational birth cohort designed to assess longitudinal associations of childcare and the presence of multiple caregivers on infant adiposity and weight trajectories throughout the first year of life. We examine as potential mediators feeding, physical activity, sleep and stress. We completed recruitment in 2015. Of the 860 women who enrolled during pregnancy, 799 delivered a single live infant who met our inclusion criteria. Of those, 666 mothers (77.4%) agreed to participate in the study for themselves and their infants.



Among the 666 women in the study, 472 (71%) identified as black, 127 (19%) as white, 7 (1%) as Asian or Asian American, 6 (1%) as Native American and 49 (7%) as other race or more than one race; 43 (7%) identified as Hispanic/Latina. Just under half (48%) had a high school diploma or less, 61% had household incomes <$20 000/year and 59% were married or living with a partner. The mean (SD) infant gestational age was 41.28 weeks (2.29) and birth weight for gestational age z-score was -0.31 (0.93). Just under half (49%) of infants were females, 69% received some human milk and 40% were exclusively breast fed at hospital discharge. Data collection began in 2013, is currently underway, and is scheduled to conclude in late 2016.



Results will help assess the magnitude of associations between childcare in infancy and subsequent obesity. Findings will also inform intervention and policy efforts to improve childcare environments and help prevent obesity in settings where many infants spend time.



Clinicaltrials.gov, NCT01788644.
Department of Health, Behavior and Society, Johns Hopkins University, Baltimore, Maryland, USA.
Sara E
SE
Benjamin Neelon
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Truls
T
Østbye
Department of Psychology and Neuroscience, Duke University, Durham, North Carolina, USA.
Gary G
GG
Bennett
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
Richard M
RM
Kravitz
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Shayna M
SM
Clancy
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Marissa
M
Stroo
Department of Statistical Science, Duke University, Durham, North Carolina, USA.
Edwin
E
Iversen
Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Cathrine
C
Hoyo
D000328:Adult; D001724:Birth Weight; D001942:Breast Feeding / Q000706:statistics & numerical data*; D017028:Caregivers; D002657:Child Development / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007182:Income / Q000706:statistics & numerical data; D007223:Infant; D007224:Infant Care / Q000379:methods*; D007231:Infant, Newborn; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D009035:Mothers; D009765:Obesity / Q000453:epidemiology*; D012107:Research Design; D014481:United States; D055815:Young Adult
adiposity; birth cohort; child care; infancy; obesity