Overview of Sinonasal and Ventral Skull Base Malignancy Management.
Significant technological advances have fostered a movement toward minimally invasive surgical interventions for the management of ventral skull base malignancies. The care of patients with these lesions ideally involves an interdisciplinary skull base team that includes otolaryngologists, neurologic surgeons, radiation oncologists, and medical oncologists. This article describes considerations essential for diagnosis, prognosis, and preoperative evaluation. Furthermore, surgical nuances, strategies for skull base reconstruction, and nonsurgical options are briefly discussed. This overview may be useful as an up-to-date description of the challenging clinical scenarios associated with these lesions.
Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine, 4201 Saint Antoine, 5E-UHC, Detroit, MI 4201, USA.
Peter F
PF
Svider
Rhinology Section, North Shore University Hospital, Manhasset, NY, USA; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA; Weill Cornell University College of Medicine, New York, NY, USA.
Michael
M
Setzen
Department of Otolaryngology - Head and Neck Surgery, Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA; Endoscopic Skull Base Surgery Program, Department of Otolaryngology - Head and Neck Surgery, Rhinology and Sinus Surgery, Otolaryngology Research, Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA.
Soly
S
Baredes
Department of Otolaryngology - Head and Neck Surgery, Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA; Endoscopic Skull Base Surgery Program, Department of Otolaryngology - Head and Neck Surgery, Rhinology and Sinus Surgery, Otolaryngology Research, Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA; Department of Neurological Surgery, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA.
James K
JK
Liu
Department of Otolaryngology - Head and Neck Surgery, Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA; Endoscopic Skull Base Surgery Program, Department of Otolaryngology - Head and Neck Surgery, Rhinology and Sinus Surgery, Otolaryngology Research, Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA; Department of Neurological Surgery, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA; Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA. Electronic address: jean.anderson.eloy@gmail.com.
Jean Anderson
JA
Eloy
D065634:Cerebrospinal Fluid Leak / Q000209:etiology; D004358:Drug Therapy; D004724:Endoscopy; D006801:Humans; D008279:Magnetic Resonance Imaging; D019060:Minimally Invasive Surgical Procedures; D000072078:Positron Emission Tomography Computed Tomography; D011878:Radiotherapy; D019651:Plastic Surgery Procedures; D019291:Skull Base / Q000000981:diagnostic imaging*; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D013524:Surgical Flaps; D016896:Treatment Outcome
Cerebrospinal fluid leakage; Chemotherapy; Radiotherapy; Sinonasal malignancy; Skull base; Skull base defect; Skull base malignancy; Skull base surgery