Pain Associated With Treatment of Dupuytren Contracture With Collagenase Clostridium histolyticum.
OBJECTIVE
The primary objective of this study was to quantify the degree of pain associated with collagenase Clostridium histolyticum (CCH) injection and to determine whether it is related to other factors in the intervention.


METHODS
A prospective study of 135 patients was performed to evaluate pain at 3 points during treatment: (1) after CCH injection, using a numerical rating scale (NRS), (2) a binary (positive/negative) assessment before manipulation 24 hours after CCH and after removing the bandage, and (3) after joint manipulation performed with wrist block anesthesia.


RESULTS
The average NRS for pain during infiltration was 4.7. Pain was present before manipulation in 52.6% of patients. Pain from manipulation showed an average NRS score of 3.6. The amounts of pain at CCH infiltration, pain after 24 hours, and pain from the manipulation were correlated because patients who experienced pain during CCH infiltration were more likely to report experiencing pain during manipulation.


CONCLUSIONS
Collagenase Clostridium histolyticum injection for treating Dupuytren contracture can be a painful process. There is a clear relationship between a patient's level of pain during injection of CCH and the likelihood that the patient will experience pain during manipulation, even with the use of local anesthesia.


METHODS
Prognostic IV.
Orthopedics and Traumatology Service, Hospital de Denia, Dénia, Alicante, Spain; University of Granada, Granada, Spain. Electronic address: rafael.sanjuan@marinasalud.es.
Rafael
R
Sanjuan-Cerveró
Pharmacy Service, Hospital Dr Moliner, Porta Coeli s/n Serra, Valencia, Spain.
Francisco J
FJ
Carrera-Hueso
University of Granada, Granada, Spain; Ophtalmologic Department, Hospital Virxen da Xunqueira, Cee, A Coruña, Spain.
Pedro
P
Vazquez-Ferreiro
Academic Center in Pharmaceutical Care, University of Granada, Granada, Spain.
Narjis
N
Fikri-Benbrahim
Orthopedics and Traumatology Service, Hospital de Denia, Dénia, Alicante, Spain.
Nuria
N
Franco-Ferrando
College of Human Medicine, Michigan State University, East Lansing; and the UP Health System-Marquette/Duke-LifePoint, Marquette, MI.
Clayton A
CA
Peimer
D000368:Aged; D047009:Hathewaya histolytica; D004387:Dupuytren Contracture / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional / Q000009:adverse effects; D008297:Male; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000627:therapeutic use*; D010147:Pain Measurement; D011446:Prospective Studies; D016896:Treatment Outcome
D003012:Microbial Collagenase
Collagenase Clostridium histolyticum; Dupuytren disease; extension; injection; pain