Successful treatment of Talaromyces amestolkiae pulmonary infection with voriconazole in an acute lymphoblastic leukemia patient.
Infections due to Talaromyces spp. are uncommon, but they have been reported previously as causative agents of disease in immunocompromised patients. The prognosis of hemato-oncological patients with an invasive fungal infection is generally poor and the identification of the causative agent is usually not achieved or in some cases the isolated agent is taken as a contaminant and not treated, which contributes to their bad outcome. We report a case of Talaromyces amestolkiae pulmonary infection in an acute lymphoblastic leukemia patient, which was successfully treated with voriconazole, and discuss the importance of molecular identification and treatment of non-traditionally pathogenic fungi in this specific subset of patients.
Infectious Diseases Department, University Hospital "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Hiram
H
Villanueva-Lozano
Microbiology Department, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Rogelio de J
RJ
Treviño-Rangel
Pulmonary and Critical Care Department, University Hospital "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Erick W
EW
Renpenning-Carrasco
Microbiology Department, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address: gmglez@yahoo.com.mx.
Gloria M
GM
González
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy; D009181:Mycoses / Q000150:complications / Q000188:drug therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D032901:Talaromyces; D065819:Voriconazole / Q000627:therapeutic use*; D055815:Young Adult
D000935:Antifungal Agents; D065819:Voriconazole
Immunocompromised; Leukemia; Talaromyces amestolkiae; Voriconazole