Silver-Mediated Radical C(sp3)-H Biphosphinylation and Nitration of β-Alkynyl Ketones for Accessing Functional Isochromenes.
Silver-mediated C(sp3)-H functionalization and 6-endo-dig oxo-cyclization of conjugated β-alkynyl ketones have been established under oxidative conditions. The reaction leads to the concise formation of a wide range of isochromenes via C(sp3)-H bond-breaking and radical addition steps. Dual and monofunctional isochromene products were selectively controlled by using either electron-rich or electron-deficient radical sources.
School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.|College of Chemistry and Molecular Engineering and Biotechnology and Pharmaceutical Engineering, Nanjing Tech University , Nanjing 210009, Jiangsu, P. R. China.
Jun
J
Sun
School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.|College of Chemistry and Molecular Engineering and Biotechnology and Pharmaceutical Engineering, Nanjing Tech University , Nanjing 210009, Jiangsu, P. R. China.
Jiang-Kai
JK
Qiu
School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.
Ya-Nan
YN
Wu
School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.
Wen-Juan
WJ
Hao
College of Chemistry and Molecular Engineering and Biotechnology and Pharmaceutical Engineering, Nanjing Tech University , Nanjing 210009, Jiangsu, P. R. China.
Cheng
C
Guo
Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.
Guigen
G
Li
School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.
Shu-Jiang
SJ
Tu
School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.
Bo
0000-0003-3878-515X
B
Jiang