The Histopathological Findings of Patients Who Underwent Blepharoplasty Due to Dermatochalasis.
OBJECTIVE
To assess changes in lymphatic vessels, collagen, and elastic fiber structure in excised tissues with dermatochalasis (DC).


METHODS
In this prospective histopathological study, 70 upper eyelid skins of 35 patients operated on for dermatochalasis were compared with 10 eyelid skins of 10 patients operated on for other diagnoses. In histopathological examination, the two groups of patients were compared with respect to number of lymphatic vessels, largest lymphatic vessel diameter, number of elastic fibers, number of macrophages, edema between collagen fibers, and depth of stromal collagen bed.


RESULTS
As compared to the control group, the study group had a significantly greater number of dilated lymphatic vessels (p = 0.0001), largest lymphatic vessel diameter (p = 0.02), depth of stromal collagen bed (p = 0.0001), edema space between collagen fibers (p = 0.0001), elastic fiber density (p = 0.0001), and number of macrophages (p = 0.001).


CONCLUSIONS
According to the results of the present study, in addition to an increase in the diameter and number of lymphatic vessels, a reduction in elastic fibers that are essential for the structure and function of lymphatic system, disarrangement in collagen fibers, stromal edema, and increased number of macrophages play a role in the development of dermatochalasis.
a Department of Ophthalmology , Ankara Training and Research Hospital , Ankara , Turkey.
Ali
A
Karnaz
a Department of Ophthalmology , Ankara Training and Research Hospital , Ankara , Turkey.
Yasemin Aslan
YA
Katircioglu
a Department of Ophthalmology , Ankara Training and Research Hospital , Ankara , Turkey.
Evin Singar
ES
Ozdemir
b Department of Pathology , Ankara Training and Research Hospital , Ankara , Turkey.
Pınar
P
Celebli
b Department of Pathology , Ankara Training and Research Hospital , Ankara , Turkey.
Sema
S
Hucumenoglu
a Department of Ophthalmology , Ankara Training and Research Hospital , Ankara , Turkey.
Firdevs
F
Ornek
D000328:Adult; D000368:Aged; D019882:Blepharoplasty; D016022:Case-Control Studies; D003094:Collagen / Q000378:metabolism; D003483:Cutis Laxa / Q000473:pathology* / Q000601:surgery; D004547:Elastic Tissue / Q000473:pathology; D005143:Eyelids / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D042601:Lymphatic Vessels / Q000473:pathology; D008264:Macrophages / Q000166:cytology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D003094:Collagen
Blepharoplasty; dermatochalasis; histopathology