The peritumoural adipose tissue microenvironment and cancer. The roles of fatty acid binding protein 4 and fatty acid binding protein 5.
The adipose tissue microenvironment plays a key role in tumour initiation and progression because it provides fatty acids and adipokines to tumour cells. The fatty acid-binding protein (FABP) family is a group of small proteins that act as intracellular fatty acid transporters. Adipose-derived FABPs include FABP4 and FABP5. Both have an important role in lipid-related metabolic processes and overexpressed in many cancers, such as breast, prostate, colorectal and ovarian. Moreover, their expression in peritumoural adipose tissue is deregulated, and their circulating levels are upregulated in some tumours. In this review, we discuss the role of the peritumoural adipose tissue and the related adipokines FABP4 and FABP5 in cancer initiation and progression and the possible pathways implicated in these processes.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Centre d'R+D+I en Nutrició i Salut, Avda. de la Universitat, 43204 Reus, Spain; Research Unit on Lipids and Atherosclerosis, Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Universitat Rovira i Virgili, Sant Llorenç, 21 43201 Reus, Spain; Institut d'Oncologia de la Catalunya Sud (IOCS), Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Av. del Dr, Josep Laporte, 2, 43204 Reus, Spain. Electronic address: sandra.guaita@urv.cat.
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Guaita-Esteruelas
Institut d'Oncologia de la Catalunya Sud (IOCS), Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Av. del Dr, Josep Laporte, 2, 43204 Reus, Spain; Department of Medicine and Surgery, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201 Reus, Spain.
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Gumà
Research Unit on Lipids and Atherosclerosis, Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Universitat Rovira i Virgili, Sant Llorenç, 21 43201 Reus, Spain.
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Masana
Institut d'Oncologia de la Catalunya Sud (IOCS), Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Av. del Dr, Josep Laporte, 2, 43204 Reus, Spain; Department of Medicine and Surgery, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201 Reus, Spain.
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Borràs
D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology*; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D059016:Tumor Microenvironment
C493410:FABP4 protein, human; C493412:FABP5 protein, human; D050556:Fatty Acid-Binding Proteins
Adipose tissue; Cancer associated adipocytes; FABP4; FABP5; Lipid metabolism