The role of pancreatic cancer-derived exosomes in cancer progress and their potential application as biomarkers.
Pancreatic cancer is one of the most deadly cancers, with dismal prognosis due to its poor early detection rate and high metastatic rate. Thus, elucidation of the molecular mechanisms accounting for its metastasis and discovery of competent biomarkers is required. Exosomes are multivesicular body-derived small extracellular vesicles released by various cell types that serve as important message carriers during intercellular communication. They are also known to play critical roles during cancer-genesis, cancer-related immune reactions, and metastasis. They also possess promising potential as novel biomarkers for cancer early detection. Therefore, extensive studies on pancreatic cancer-derived exosomes are currently being performed because they hold the promising potential of elevating the overall survival rate of patients with pancreatic cancer. In the present review, we focus on the role of exosomes in pancreatic cancer-related immune reactions, metastasis, and complications, and on their potential application as pancreatic cancer biomarkers.
Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
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Jin
Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
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Wu
Department of Pancreatic and Thyroidal Surgery, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, People's Republic of China. 2558177703@qq.com.
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http://orcid.org/0000-0002-6685-1102
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Tan
D014408:Biomarkers, Tumor / Q000235:genetics*; D055088:Early Detection of Cancer; D055354:Exosomes / Q000235:genetics*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics
D014408:Biomarkers, Tumor
Cancer biomarker; Exosomes; Immunology; Metastasis; Pancreatic cancer