The effects of oral administration of Yunnan Baiyao on blood coagulation in beagle dogs as measured by kaolin-activated thromboelastography and buccal mucosal bleeding times.
We examined the effects of oral administration of Yunnan Baiyao (YB) on hemostasis by measuring buccal mucosal bleeding times (BMBTs) and doing citrated kaolin-activated whole-blood thromboelastography (TEG). In a randomized controlled crossover trial 8 beagle dogs were given either placebo or 1000 mg of YB orally every 12 h for 5 consecutive treatments. Blood was drawn 24 h before treatment and 2 and 24 h after the last treatment, and the BMBT was measured in each sample in duplicate. The TEG analysis was done in duplicate 60 ± 5 min after sample collection. There were no adverse effects of treatment and no significant differences between the control and treatment BMBTs or TEG parameters at any time point. Significant differences were found between baseline and 24 h after the last treatment within the treatment group for the TEG parameters LY30 and LY60 and within the control group for the TEG parameters MA, G, LY30, and LY60. Thus, at the dose and frequency of administration in this study YB did not appear to have any clinically significant effects on the measured coagulation parameters. The differences within the treatment group were likely due to analytic error since similar differences were seen in the control group. Further studies with a larger sample, as well as more direct measures of platelet function, are needed.
Department of Veterinary Clinical & Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Boysen); Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T3G 4Z7.
Jami
J
Frederick
Department of Veterinary Clinical & Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Boysen); Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T3G 4Z7.
Søren
S
Boysen
Department of Veterinary Clinical & Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Boysen); Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T3G 4Z7.
Catherine
C
Wagg
Department of Veterinary Clinical & Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Boysen); Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T3G 4Z7.
Serge
S
Chalhoub
D000284:Administration, Oral; D000818:Animals; D001760:Bleeding Time / Q000662:veterinary*; D001777:Blood Coagulation / Q000187:drug effects*; D018592:Cross-Over Studies; D004285:Dogs / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology*; D009061:Mouth Mucosa; D013916:Thrombelastography
D004365:Drugs, Chinese Herbal; D006490:Hemostatics; C530960:yunnan baiyao