Fluorescence Imaging for Cancer Screening and Surveillance.
The advent of fluorescence imaging (FI) for cancer cell detection in the field of oncology is promising for both cancer screening and surgical resection. Particularly, FI in cancer screening and surveillance is actively being evaluated in many new clinical trials with over 30 listed on Clinical Trials.gov . While surgical resection forms the foundation of many oncologic treatments, early detection is the cornerstone for improving outcomes and reducing cancer-related morbidity and mortality. The applications of FI are twofold as it can be applied to high-risk patients in addition to those undergoing active surveillance. This technology has the promise of highlighting lesions not readily detected by conventional imaging or physical examination, allowing disease detection at an earlier stage of development. Additionally, there is a persistent need for innovative, cost-effective imaging modalities to ameliorate healthcare disparities and the global burden of cancer worldwide. In this review, we outline the current utility of FI for screening and detection in a range of cancer types.
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
K E
KE
Tipirneni
Department of Otolaryngology, Stanford University, Stanford, CA, USA.
E L
EL
Rosenthal
Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, USA.
L S
LS
Moore
Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, USA.
A D
AD
Haskins
Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
N
N
Udayakumar
School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
A H
AH
Jani
Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, USA.
W R
WR
Carroll
Department of Oral and Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
A B
AB
Morlandt
Department of Pathology, Stanford University, Stanford, CA, USA.
M
M
Bogyo
Department of Radiology, Stanford University, Stanford, CA, USA.
J
J
Rao
Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, USA. mojack@uab.edu.|Departments of Otolaryngology, Neurosurgery, & Radiology, The University of Alabama at Birmingham, Birmingham, AL, USA. mojack@uab.edu.
Jason M
JM
Warram
D002986:Clinical Trials as Topic; D003952:Diagnostic Imaging / Q000379:methods*; D055088:Early Detection of Cancer; D005453:Fluorescence; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D011159:Population Surveillance
Cancer screening; Diagnostic imaging; Early detection of cancer; Molecular imaging; Neoplasms; Optical imaging