Impact of the feedback provided by a gastric electrical stimulation system on eating behavior and physical activity levels.
The closed-loop gastric electrical stimulation (CLGES) abiliti®system provides tailored gastric electrical stimulation activated by food entry into the stomach and sensor-based data to medical professionals. The aim of this study was to analyze behavior changes using sensor-based food intake and activity data in participants treated with the CLGES system.



Food intake and activity data (3D accelerometer) were downloaded at baseline and monthly/bimonthly for 12 months in a subset of patients with obesity (N = 45) participating in a multicenter trial with CLGES. Measured food intake parameters included the number of intakes during allowed and disallowed periods, nighttime intakes, and between-meal snacks (average/d). Activity parameters included time in different levels of physical activity (min/d), sleep/sedentary (h/d), and estimated energy expenditure (EE).



Weight loss at 12 months averaged 15.7 ± 7.7% of the baseline body weight. Stable reduction in the number of disallowed meals and between-meal snacks (P < 0.05), an increase in all levels of physical activity (P < 0.001), and an increase in activity-based EE (303 ± 53 kcal/d on average, P < 0.001) were seen.



Significant improvement in eating and activity was seen in participants. It is hypothesized that feedback of the sensor-based data induced behavioral changes and contributed to weight loss in patients treated with CLGES.
University of Padua, Department of Medicine, Padua, Italy.
Luca
L
Busetto
Complutense University of Madrid, Hospital Clinico "San Carlos," Hospital Universitario Madrid Monteprincipe, Madrid, Spain.
Antonio J
AJ
Torres
Hospital Virgen del Rocio, Seville, Spain.
Salvador
S
Morales-Conde
Hospital Virgen del Rocio, Seville, Spain.
Isaias
I
Alarcón Del Agua
University Hospital Pisa, Pisa, Italy.
Carlo
C
Moretto
University Hospital Pisa, Pisa, Italy.
Paola
P
Fierabracci
Clinica San Luca, Torino, Italy.
Giuseppe
G
Rovera
Vicenza Regional Hospital, Vicenza, Italy.
Gianni
G
Segato
Complutense University of Madrid, Hospital Clinico "San Carlos," Hospital Universitario Madrid Monteprincipe, Madrid, Spain.
Miguel A
MA
Rubio
Vicenza Regional Hospital, Vicenza, Italy.
Franco
F
Favretti
D000328:Adult; D004435:Eating / Q000502:physiology; D004599:Electric Stimulation Therapy / Q000379:methods*; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D062410:Snacks; D016896:Treatment Outcome; D055815:Young Adult