Late onset cytopenias following haematopoietic stem cell transplant associated with viral infection and cell specific antibodies.
This report describes a patient who received an allogeneic haematopoietic stem cell transplant and who, following a viral infection, developed late onset cytopenias associated with antibodies against red cells, platelets and granulocytes. Investigation of these cytopenias revealed the presence of lineage specific auto- and allo-antibodies, which were not present in either the donor or in the recipient prior to the viral infection. This case provides further evidence for the concept that viral challenges following HSCT can result in the production of cell specific antibodies that can have significant implications for patient management.
Histocompatibility & Immunogenetics, National Blood and Transplant, Filton, UK. Electronic address: geoff.lucas@nhsbt.nhs.uk.
Geoff
G
Lucas
Histocompatibility & Immunogenetics, National Blood and Transplant, Filton, UK.
Steven
S
Culliford
Histocompatibility & Immunogenetics, National Blood and Transplant, Filton, UK.
Nina
N
Bendukidze
Department of Adolescent Haematology, University College Hospital's NHS Foundation Trust, London, UK.
Julia
J
Dahlstrom
Department of Adolescent Haematology, University College Hospital's NHS Foundation Trust, London, UK.
Victoria
V
Grandage
Department of Adolescent Haematology, University College Hospital's NHS Foundation Trust, London, UK.
Ben
B
Carpenter
Department of Adolescent Haematology, University College Hospital's NHS Foundation Trust, London, UK.
Rachael
R
Hough
D000293:Adolescent; D000380:Agranulocytosis / Q000097:blood / Q000209:etiology; D064591:Allografts; D001323:Autoantibodies / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology; D014777:Virus Diseases / Q000097:blood / Q000150:complications
D001323:Autoantibodies; D007518:Isoantibodies
Late onset cytopenias following HSCT