Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma.
Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, and ZHX3. Although ZHX family members have been associated with the progression of cancer, their values as prognostic factors in cancer patients have been poorly examined. Renal cell carcinoma (RCC) is a highly heterogeneous, aggressive cancer that responds variably to treatment. Thus, prognostic molecular markers are required to evaluate disease progression and to improve the survival. In clear cell RCC (ccRCC), ZHX1 and ZHX3 expression were found to be down-regulated but ZHX2 was up-regulated, and the expressions of ZHX1 and ZHX3 were significantly associated with pathological stage. Furthermore, Kaplan-Meier and multivariate regression analysis showed that reduction in the mRNA expression of ZHX1 was associated with poorer survival. Taken together, the present study shows loss of ZHX1 is correlated with ccRCC progression and suggests it is an independent prognostic marker in ccRCC.
Departments of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.|Gene & Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan, Republic of Korea.
Ryuk-Jun
RJ
Kwon
Departments of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.|Gene & Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan, Republic of Korea.
Yun Hak
YH
Kim
Department of Statistics, Korea University, Seongbuk-gu, Seoul, Republic of Korea.
Dae Cheon
DC
Jeong
Departments of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.|Gene & Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan, Republic of Korea.
Myoung-Eun
ME
Han
Departments of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.|Gene & Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan, Republic of Korea.
Ji-Young
JY
Kim
Departments of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.|Gene & Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan, Republic of Korea.
Liangwen
L
Liu
Departments of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
Jin-Sup
JS
Jung
Departments of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.|Gene & Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan, Republic of Korea.
Sae-Ock
SO
Oh
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012097:Repressor Proteins / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers
D018398:Homeodomain Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C484404:ZHX1 protein, human; C476826:ZHX2 protein, human; C476878:ZHX3 protein, human