Dermoscopic features of nail psoriasis treated with biologics.
Although psoriatic nail lesions are small, they cause considerable discomfort for patients and adversely affect quality of life. Few studies have evaluated the dermoscopic features of psoriatic nails. The aim of this study was to clarify the dermoscopic features of nail psoriasis and identify those that reflect psoriatic activity. During biologic treatment of psoriasis, six patients with psoriatic nails twice underwent dermoscopic examination, with an interval of 17-42 weeks. We used the modified Nail Psoriasis Severity Index score and Psoriasis Area and Severity Index score to identify and assess dermoscopic features. We identified 10 dermoscopic findings, of which disappearance of diffuse scaling of the nail plate, transverse step-like notches and splinter hemorrhages of the nail bed, and appearance of erythematous borders of the onycholytic area were associated with improvement in Psoriasis Area and Severity Index score. Dermoscopy can detect nail changes during psoriasis treatment and should be used to evaluate treatment success.
Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Yuki
Y
Hashimoto
Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Miki
M
Uyama
Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Yuko
Y
Takada
Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Kenji
K
Yoshida
Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Akira
A
Ishiko
D000328:Adult; D003879:Dermatologic Agents / Q000627:therapeutic use*; D046169:Dermoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000175:diagnosis* / Q000188:drug therapy; D011565:Psoriasis / Q000175:diagnosis* / Q000188:drug therapy; D000069549:Ustekinumab / Q000627:therapeutic use*
D003879:Dermatologic Agents; D000069549:Ustekinumab
Nail Psoriasis Severity Index score; biologics; dermoscopic features; dermoscopy; nail psoriasis