Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins.
The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.
Department of Engineering and Geology (INGEO), G.d'Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy.|Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France.
Andrea
A
Mascitti
Department of Engineering and Geology (INGEO), G.d'Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy.|Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France.
Massimiliano
M
Lupacchini
Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France.
Ruben
R
Guerra
P.N. Lebedev Institute of Physics of RAS, Leninskiy pr-t, 53, 119991, Moscow, Russia.|Moscow Institute of Physics and Technology, Institutskiy per., 9, 141700, Dolgoprudny, Russia.
Ilya
I
Taydakov
Department of Philosophical, Educational and Economic Sciences, G. d'Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy.
Lucia
L
Tonucci
Department of Engineering and Geology (INGEO), G.d'Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy.
Nicola
N
d'Alessandro
Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France.
Frederic
F
Lamaty
Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France.
Jean
J
Martinez
Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France.
Evelina
E
Colacino
1,1’-carbonyldiimidazole (CDI); ball-milling; hydantoins; liquid-assisted grinding (LAG); mechanochemistry; poly(ethylene) glycols (PEGs)