Electrospun curcumin-loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity.
Novel fibrous materials from cellulose acetate (CA) and polyvinylpyrrolidone (PVP) containing curcumin (Curc) with original design were prepared by one-pot electrospinning or dual spinneret electrospinning. The electrospun materials were characterized by scanning electron microscopy (SEM), fluorescence microscopy, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), differential scanning calorimetry (DSC), water contact angle measurements, and microbiological tests. It was found that the incorporation of Curc into the CA and PVP solutions resulted in an increase of the solution viscosity and obtaining fibers with larger diameters (ca. 1.5μm) compared to the neat CA (ca. 800nm) and PVP fibers (ca. 500nm). The incorporation of PVP resulted in increased hydrophilicity of the fibers and in faster Curc release. Curc was found in the amorphous state in the Curc-containing fibers and these mats exhibited antibacterial activity against Staphylococcus aureus (S. aureus). The results suggest that, due to their complex architecture, the obtained new antibacterial materials are suitable for wound dressing applications, which necessitate diverse release behaviors of the bioactive compound.
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
Petya B
PB
Tsekova
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
Mariya G
MG
Spasova
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
Nevena E
NE
Manolova
Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 26, BG-1113 Sofia, Bulgaria.
Nadya D
ND
Markova
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria. Electronic address: rashkov@polymer.bas.bg.
Iliya B
IB
Rashkov
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003474:Curcumin / Q000494:pharmacology*; D065546:Drug Liberation; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D011205:Povidone / Q000737:chemistry*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors; D014783:Viscosity; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D012996:Solutions; D014867:Water; C005062:acetylcellulose; D002482:Cellulose; D011205:Povidone; D003474:Curcumin
Antibacterial activity; Cellulose acetate; Curcumin; Electrospinning; Polyvinylpyrrolidone; Wound dressings