Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: synthesis and drug release.
Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgelof 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h.



A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed.
Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Haliza
H
Katas
Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Chai Yi
CY
Wen
Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Muhammad Irfan
MI
Siddique
Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia.
Zahid
Z
Hussain
Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Fatin Hanini
FH
Mohd Fadhil
D048271:Chitosan; D003474:Curcumin / Q000737:chemistry*; D003920:Diabetes Mellitus / Q000473:pathology*; D004337:Drug Carriers; D065546:Drug Liberation; D005782:Gels; D053758:Nanoparticles; D034741:RNA, Small Interfering / Q000737:chemistry*; D014947:Wounds and Injuries / Q000188:drug therapy*
D004337:Drug Carriers; D005782:Gels; D034741:RNA, Small Interfering; D048271:Chitosan; D003474:Curcumin
RNA interfering; nanotechnology; topical delivery