Microglial Barriers to Viral Gene Delivery.
In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable cells following viral infection.
Stem Cell Biology and Regenerative Medicine Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
John V
JV
Pluvinage
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: twc@stanford.edu.
Tony
T
Wyss-Coray
D002490:Central Nervous System; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D017628:Microglia; D009474:Neurons