The role of myosin II in glioma invasion: A mathematical model.
Gliomas are malignant tumors that are commonly observed in primary brain cancer. Glioma cells migrate through a dense network of normal cells in microenvironment and spread long distances within brain. In this paper we present a two-dimensional multiscale model in which a glioma cell is surrounded by normal cells and its migration is controlled by cell-mechanical components in the microenvironment via the regulation of myosin II in response to chemoattractants. Our simulation results show that the myosin II plays a key role in the deformation of the cell nucleus as the glioma cell passes through the narrow intercellular space smaller than its nuclear diameter. We also demonstrate that the coordination of biochemical and mechanical components within the cell enables a glioma cell to take the mode of amoeboid migration. This study sheds lights on the understanding of glioma infiltration through the narrow intercellular spaces and may provide a potential approach for the development of anti-invasion strategies via the injection of chemoattractants for localization.
National Institute for Mathematical Sciences, Daejeon, 34047, Republic of Korea.
Wanho
W
Lee
Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, 45221, United States of America.
Sookkyung
S
Lim
Mathematical Biosciences Institute, Ohio State University, Columbus, OH, 43210, United States of America.|Department of Mathematics, Konkuk University, Seoul, 05029, Republic of Korea.
Yangjin
Y
Kim
D000199:Actins / Q000378:metabolism; D000465:Algorithms; D000818:Animals; D001696:Biomechanical Phenomena; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002630:Chemotactic Factors / Q000378:metabolism; D004058:Diffusion; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008962:Models, Theoretical; D024462:Myosin Type II / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D051381:Rats
D000199:Actins; D002630:Chemotactic Factors; D024462:Myosin Type II