Quality of life in an Italian cohort of people living with HIV in the era of combined antiretroviral therapy (Evidence from I.A.N.U.A. study-investigation on antiretroviral therapy).
The aims of this study were to assess the Health Related Quality of Life (HRQoL) of People Living with HIV/AIDS (PLWHA) who attend outpatient services in Genoa, Italy, and to evaluate the relationship between HRQoL and clinical factors, primarily: CD4+ cell count, viral load and HIV-Hepatitis C Virus (HCV) coinfection. A cross-sectional study was performed involving a sample of 943 consecutive patients. Firstly the EuroQol-Five Dimensions-Three Level (EQ-5D-3L) self-reported questionnaire was used to evaluate HRQoL, while socio-demographic information was collected using a separate self-administered questionnaire. Descriptive statistical analysis was then used to show the socio-demographic and clinical characteristics of the sample. Having characterized the sample, Pearson's correlation technique was used to assess the relationship between HRQoL and socio-demographic and clinical characteristics. Finally, multivariable linear regression was used to determine factors associated with HRQOL. The median EQ-Visual analogue scale (EQ-VAS) score was 75.4 (SD 18.4). We found statistically significant associations between the EQ-VAS score and age, coinfection with HCV+, education, other drugs taken over cART, hospitalization due to HIV and a CD4+ cell count <200 mm3compared with CD4+ cell count >500 mm3. Factors independently associated with lower HRQoL were: older age, coinfection with HCV+, other drugs used in addition to cART, hospitalization due to HIV and CD4+ cell count <200 mm3compared with CD4+ cell count >500 mm3.
a S.C. Malattie Infettive, E.O. Ospedali Galliera.
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Venturini
a S.C. Malattie Infettive, E.O. Ospedali Galliera.
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G
Cenderello
b Clinica di Malattie Infettive, Università di Genova. IRCCS AOU San Martino - IST.
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0000-0003-1436-5089
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Di Biagio
c Dipartimento di Informatica, Bioingegneria, Robotica e Ingegneria dei Sistemi , Università di Genova.
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B
Giannini
d Dipartimento di Economia , Università di Genova.
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M
Ameri
c Dipartimento di Informatica, Bioingegneria, Robotica e Ingegneria dei Sistemi , Università di Genova.
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M
Giacomini
d Dipartimento di Economia , Università di Genova.
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M
Montefiori
e Clinica di Medicina Interna ad Orientamento Immunologico, Università di Genova. IRCCS AOU San Martino - IST.
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Setti
b Clinica di Malattie Infettive, Università di Genova. IRCCS AOU San Martino - IST.
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Mazzarello
f Agenzia Regionale Sanitaria, Regione Liguria.
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C
Merlano
f Agenzia Regionale Sanitaria, Regione Liguria.
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P
Orcamo
b Clinica di Malattie Infettive, Università di Genova. IRCCS AOU San Martino - IST.
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Viscoli
a S.C. Malattie Infettive, E.O. Ospedali Galliera.
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G
Cassola
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D019562:Viral Load; D055815:Young Adult
D044966:Anti-Retroviral Agents
CD4+; HIV; HIV-RNA; coinfection HIV-HCV; quality of life