The A445C Variant in Apelin Receptor and Diabetic Retinopathy in Tunisian Patients.
BACKGROUND
Apelin and apelin receptor (APLN/APLNR) are involved in the retinal neovascularization of diabetic retinopathy (DR).


METHODS
This study investigated the impact of the APLNR A445C variant on the risk of DR in a sample of the Tunisian population (100 patients with DR and 105 healthy controls) using PCR-RFLP.


RESULTS
The genotype frequencies of the APLNR A445C variant were not significantly different between the patient and control groups. The genotype was not associated with DR (OR = 1.49; 95% CI [0.49 - 4.48], p = 0.47 for the AC heterozygous genotype and OR = 1.57; 95% CI [0.43 - 5.71], p = 0.49 for the CC homozygous genotype). Furthermore, the clinical and biochemical parameters according to the APLNR A445C genotypes revealed that only total cholesterol (TC) was significantly higher in the DR group with the CC genotype compared to the AA genotype (p < 0.02).


CONCLUSIONS
The APLNR A445C polymorphism was not associated with DR in a sample of the Tunisian population, but the CC genotype carrier patients with DR had a high TC concentration.
Hayet
H
Soualmia
Fatma
F
Midani
Sondess
S
Hadj-Fradj
Nedra
N
Saadi
Mehdi
M
Lassoued
Taieb
T
Messoud
Monia
M
Gharbi
Zohra
Z
Ben-Amor
D054458:Amplified Fragment Length Polymorphism Analysis; D000075244:Apelin Receptors / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002784:Cholesterol / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D014416:Tunisia
C104575:APLNR protein, human; D000075244:Apelin Receptors; D002784:Cholesterol