Prognostic Value of miR-222 in Various Cancers: a Systematic Review and Meta-Analysis.
BACKGROUND
MicroRNAs (miRNAs) play important roles in cancer development. MiR-222, which is deregulated in multiple types of cancers, shows potential as a prognostic biomarker; however, the association between miR222 expression and cancer prognosis was controversial in previous studies. Here we analyzed the relationship between miR-222 and the survival of cancer patients.


METHODS
A systematic search of PubMed, Web of Science, Ovid, SciFinder, Cochrane Library, Wan Fang, and the Chinese National Knowledge Infrastructure databases up until June 8, 2015 was performed to clarify the prognostic value of miR-222 in cancers. The hazard ratio (HR) and 95% confidence interval (95% CI) were extracted to evaluate the effect.


RESULTS
Sixteen published articles involving 1,354 patients were included in this meta-analysis. High expression of miR-222 was associated with poor overall survival with a pooled HR of 1.86 (95% CI, 1.57 - 2.14), without significant heterogeneity, and no publication bias was detected.


CONCLUSIONS
Our results showed that high expression of miR-222 is associated with poor overall survival of patients with cancers and could be used as a predictive biomarker for prognosis of various cancers.
Tai
T
Wei
Peng
P
Ye
Xin
X
Peng
Li-Ling
LL
Wu
Guang-Yan
GY
Yu
D014408:Biomarkers, Tumor / Q000032:analysis; D018572:Disease-Free Survival; D006801:Humans; D035683:MicroRNAs / Q000032:analysis*; D009369:Neoplasms / Q000235:genetics / Q000401:mortality*; D011379:Prognosis
D014408:Biomarkers, Tumor; D035683:MicroRNAs; C525710:MIR222, human