Potential regulatory mechanisms of lncRNA in diabetes and its complications.
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides without protein-coding potential. Although these molecules were initially considered as "junk products" of transcription without biological relevance, recent advances in research have shown that lncRNA plays an important role, not only in cellular processes such as proliferation, differentiation, and metabolism, but also in the pathological processes of cancers, diabetes, and neurodegenerative diseases. In this review, we focus on the potential regulatory roles of lncRNA in diabetes and the complications associated with diabetes.
a Department of Social Medicine and Health Service Management, School of Public Health, University of South China, Hengyang, China.
Shui-Dong
SD
Feng
b Department of Physiology, School of Medicine, University of South China, Hengyang, China.
Ji-Hua
JH
Yang
c Laboratory of Cell & Molecular Biology, Palmer Center for Chiropractic Research, Port Orange, Florida, USA.
Chao Hua
CH
Yao
b Department of Physiology, School of Medicine, University of South China, Hengyang, China.
Si-Si
SS
Yang
b Department of Physiology, School of Medicine, University of South China, Hengyang, China.
Ze-Mei
ZM
Zhu
b Department of Physiology, School of Medicine, University of South China, Hengyang, China.
Di
D
Wu
b Department of Physiology, School of Medicine, University of South China, Hengyang, China.
Hong-Yan
HY
Ling
c Laboratory of Cell & Molecular Biology, Palmer Center for Chiropractic Research, Port Orange, Florida, USA.
Liang
L
Zhang
D000818:Animals; D048909:Diabetes Complications / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*
D062085:RNA, Long Noncoding
complications diabétiques; diabetes; diabetic complications; diabète; lncRNA; longs ARNnc