Validation of a risk stratification tool for fall-related injury in a state-wide cohort.
A major preventable contributor to healthcare costs among older individuals is fall-related injury. We sought to validate a tool to stratify such risk based on readily available clinical data, including projected medication adverse effects, using state-wide medical claims data.



Sociodemographic and clinical features were drawn from health claims paid in the state of Massachusetts for individuals aged 35-65 with a hospital admission for a period spanning January-December 2012. Previously developed logistic regression models of hospital readmission for fall-related injury were refit in a testing set including a randomly selected 70% of individuals, and examined in a training set comprised of the remaining 30%. Medications at admission were summarised based on reported adverse effect frequencies in published medication labelling.



The Massachusetts health system.



A total of 68 764 hospitalised individuals aged 35-65 years.



Hospital readmission for fall-related injury defined by claims code.



A total of 2052 individuals (3.0%) were hospitalised for fall-related injury within 90 days of discharge, and 3391 (4.9%) within 180 days. After recalibrating the model in a training data set comprised of 48 136 individuals (70%), model discrimination in the remaining 30% test set yielded an area under the receiver operating characteristic curve (AUC) of 0.74 (95% CI 0.72 to 0.76). AUCs were similar across age decades (0.71 to 0.78) and sex (0.72 male, 0.76 female), and across most common diagnostic categories other than psychiatry. For individuals in the highest risk quartile, 11.4% experienced fall within 180 days versus 1.2% in the lowest risk quartile; 57.6% of falls occurred in the highest risk quartile.



This analysis of state-wide claims data demonstrates the feasibility of predicting fall-related injury requiring hospitalisation using readily available sociodemographic and clinical details. This translatable approach to stratification allows for identification of high-risk individuals in whom interventions are likely to be cost-effective.
Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Thomas H
TH
McCoy
Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.|Partners Research Computing, Partners HealthCare System, One Constitution Center, Boston, Massachusetts, USA.|Laboratory of Computer Science and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.|Information Systems, Partners HealthCare System, Boston, Massachusetts, USA.
Victor M
VM
Castro
Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.|Partners Research Computing, Partners HealthCare System, One Constitution Center, Boston, Massachusetts, USA.|Laboratory of Computer Science and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.|Information Systems, Partners HealthCare System, Boston, Massachusetts, USA.
Andrew
A
Cagan
Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ashlee M
AM
Roberson
Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Roy H
RH
Perlis
D000058:Accidental Falls / Q000517:prevention & control / Q000706:statistics & numerical data*; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D016208:Databases, Factual; D005260:Female; D017048:Health Care Costs; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D010359:Patient Readmission / Q000706:statistics & numerical data*; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013997:Time Factors
adverse effects; fall-related injury; health claims; precision medicine; prediction; risk stratification