Thrombotic thrombocytopenic purpura in a new onset lupus patient?
We are presenting a case of TTP with undetectable levels of ADAMTS 13 in a 39-year-old woman. Diagnosis of systemic lupus was evoked in the setting of thrombotic microangiopathy. The patient presented normal renal function but important neurological impairment. Treatment with daily plasmapheresis as well as Rituximab, cyclophosphamide as steroids was required to achieve clinical improvement.
Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas, Spain.
Nery Sablón
NS
González
Centre Hospitalier Saint Cyr, Lyon, France. noellorenzo@gmail.com.
Noel
N
Lorenzo
Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas, Spain.
Yanet
Y
Parodis
Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas, Spain.
Maria Belen Alonso
MBA
Ortiz
Hopital Universitaire Fattouma Bourguiba, Monastir, Tunisia.
Melek
M
Kechida
Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas, Spain.
Jose Carlos Rodriguez
JCR
Perez
D000328:Adult; D000743:Anemia, Hemolytic / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology*; D003061:Codeine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic; D010956:Plasmapheresis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis* / Q000276:immunology; D012074:Remission Induction; D000069283:Rituximab / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000188:drug therapy*
D001323:Autoantibodies; D000069283:Rituximab; D006886:Hydroxychloroquine; D003520:Cyclophosphamide; D003061:Codeine
Lupus; Microangiopathic hemolytic anemia; Thrombotic thrombocytopenic purpura