The Hunger Games: Salmonella, Anorexia, and NLRP3.
Rao and colleagues (2017) reveal how Salmonella limits anorexia in mice, protecting them and promoting the spread of infection. The mechanism involves inhibition of the NLRP3 inflammasome limiting vagal nerve stimulation by IL-1β, which in turn promotes appetite. A possible new therapeutic approach for treating anorexia in multiple diseases is proposed.
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.
Luke A J
LAJ
O'Neill
D000818:Animals; D000855:Anorexia; D002352:Carrier Proteins; D006815:Hunger; D058847:Inflammasomes; D053583:Interleukin-1beta; D051379:Mice; D008810:Mice, Inbred C57BL; D012475:Salmonella
D002352:Carrier Proteins; D058847:Inflammasomes; D053583:Interleukin-1beta