Gamma Knife radiosurgery for the treatment of intracranial dural arteriovenous fistulas.
Background Intracranial dural arteriovenous fistulae (DAVF) may present a treatment challenge. Endovascular embolization is in most cases the first line of treatment but does not always achieve cure. Gamma Knife (GK) radiosurgery represents an alternative treatment option, and the purpose of this study was to further evaluate its utility. Methods We reviewed all cases of DAVF treated between 2009 and 2016 at our institution with GK radiosurgery independently, or following failed/refused endovascular or surgical management. Patients' clinical files, radiological images, catheter angiograms, and surgical DAVF disconnection reports were retrospectively reviewed. Results Sixteen DAVF (14 patients) treated by GK radiosurgery were identified. Eleven fistulae were aggressive and five were benign. Marginal doses ranged from 15 to 25 Gy. Target volumes ranged from 0.04 to 4.47 cm3. In all symptomatic patients, GK treatment resulted in symptom palliation. In 13/15 lesions, cure of symptoms (86.0%) was reported. One lesion was asymptomatic. Angiographic cure was achieved in eight cases (50%), small residual DAVF occurred in four, and four were unchanged. One patient developed headache that resolved at one year. No hemorrhage occurred during the follow-up period. There was no significant association between Borden type and cure rate. Prior failed endovascular treatment and small target volume were associated with lower rates of cure. Conclusions Stereotactic radiosurgery is viable treatment for DAVF. It is very effective in palliating symptoms as a de novo approach or adjunctive to endovascular therapy. In our experience it is only somewhat effective in achieving complete angiographic cure.
1 Department of Medical Imaging, Division of Neuroradiology, Toronto Western Hospital, University Health Network & University of Toronto, Canada.
Adam A
AA
Dmytriw
2 Department of Neurosurgery, Sunnybrook Health Sciences Centre and Gamma Knife Centre, Toronto Western Hospital, Canada.
Michael L
ML
Schwartz
3 Department of Neurosurgery, St. Michael's Hospital, Canada.
Michael D
MD
Cusimano
1 Department of Medical Imaging, Division of Neuroradiology, Toronto Western Hospital, University Health Network & University of Toronto, Canada.
Vitor
V
Mendes Pereira
1 Department of Medical Imaging, Division of Neuroradiology, Toronto Western Hospital, University Health Network & University of Toronto, Canada.
Timo
T
Krings
4 Department of Neurosurgery, Toronto Western Hospital, University Health Network, Canada.
Michael
M
Tymianski
4 Department of Neurosurgery, Toronto Western Hospital, University Health Network, Canada.
Ivan
I
Radovanovic
1 Department of Medical Imaging, Division of Neuroradiology, Toronto Western Hospital, University Health Network & University of Toronto, Canada.
Ronit
R
Agid
D000328:Adult; D000368:Aged; D020785:Central Nervous System Vascular Malformations / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000295:instrumentation*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome
Dural arteriovenous fistula; Gamma Knife radiosurgery; central nervous system vascular malformations; treatment outcome