DD Genotype of the angiotensin - converting enzyme gene and stroke in Slovenian population.
The angiotensin-converting enzyme (ACE) is a rate-limiting enzyme in the renin angiotensin system, the enzyme is involved in the vascular remodelling and atherosclerosis. Its significance in pathogenesis of ischemic cerebrovascular insults (CVI) is not known. We analysed 124 Slovenian patients with CVI and compared them with 161 healthy controls for I/D polymorphism. Under a recessive model (χ2= 1.76, p= 0.1, OR = 1.40, 95% CI: 0.85 - 2.34) we found no significant difference in I/D genotypes between patients with CVI and controls. This study shows that in a group of Slovenian CVI patients the DD genotype is not an important risk factor for the development of stroke.
Division of Medical Genetics, Department of Obstetrics and Gynecology, UMC Ljubljana, Šlajmerjeva 4, 1000 Ljubljana, Slovenia, , , , , , SI.
Borut
B
Peterlin
Division of Medical Genetics, Department of Obstetrics and Gynecology, UMC Ljubljana, Šlajmerjeva 4, 1000 Ljubljana, Slovenia, , , , , , SI.
Tomaž
T
Milanez
Department of Neurology, UMC Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia, , , , , , SI.
Jan
J
Kobal
Institute for Rehabilitation, Republic of Slovenia, Linhartova 51, 1000 Ljubljana, Slovenia, , , , , , SI.
Karmen
K
Peterlin-Potisk
Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Korytkova 2,1000 Ljubljana, Slovenia, , , , , , SI.
Daniel
D
Petrovič
Department of Neurology, UMC Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia, , , , , , SI.
Anton
A
Grad
Department of Neurology, UMC Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia, , , , , , SI.
Tomaž
T
Pogačnik
Key words: angiotensin-converting enzyme; genetic polymorphism; risk factor; stroke