Food effect: The combined effect of media pH and viscosity on the gastrointestinal absorption of ciprofloxacin tablet.
BACKGROUND
The clinical implications of food-drug interactions may have to be taken seriously into account with oral drugs administration in order to minimize variations in drug bioavailability. Food intake may alter physiological changes in the pH and viscosity of the gastrointestinal lumen, which could affect the oral absorption of drugs.


OBJECTIVE
The aim of the present study was to have an insight on the effect of media parameters: viscosity and pHon the oral absorption of ciprofloxacin HCl from solid formulations using a model food: Corchorus olitorius (Jute) Soup.


METHODS
In vitro disintegration and dissolution rates of ciprofloxacin tablet were evaluated using compendia buffer media in the presence/absence of C. olitorius leaves. These in vitro data were then input to GastroPlus™ to predict ciprofloxacin absorption profiles under fasted and fed states.


RESULTS
The present study demonstrated the significance of luminal pH and viscosity on the dissolution and disintegration of solid formulations following postprandial ingestion of the viscous soup. The tablets showed prolonged disintegration times and reduced dissolution rates in this soup, which could be attributed to the postprandial elevation in media viscosity and reduced solubility at elevated gastricpH. The predicted model under fed state showed no impact on AUC but prolonged Tmaxand a decrease in Cmax.


CONCLUSIONS
Concomitant intake of C. olitorius soup with ciprofloxacin might have negative effect on the rate of drug release from conventional immediate release tablets.
Department of Pharmacy, An-Najah National University, Nablus, Palestine. Electronic address: asma.radwan@najah.edu.
Asma
A
Radwan
Department of Pharmacy, An-Najah National University, Nablus, Palestine.
Abdel Naser
AN
Zaid
Department of Pharmacy, An-Najah National University, Nablus, Palestine.
Nidal
N
Jaradat
Pharmacare Ltd. Beitunia, Ramallah, Palestine.
Yousef
Y
Odeh
D000284:Administration, Oral; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002939:Ciprofloxacin / Q000378:metabolism*; D018565:Food-Drug Interactions / Q000502:physiology*; D065569:Gastrointestinal Absorption / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019660:Malvaceae / Q000009:adverse effects*; D019518:Postprandial Period; D012995:Solubility; D013607:Tablets / Q000378:metabolism*; D014783:Viscosity
D013607:Tablets; D002939:Ciprofloxacin
Ciprofloxacin; Corchorus olitorius; Food effect; Oral absorption; Physiological modeling; Viscosity