Potential diagnostic and prognostic significance of plasma prolidase activity in gastric cancer.
OBJECTIVE
Plasma prolidase activities (PPAs) in cases of gastric cancer.


RESULTS
This study was based on a prospective design. 60 patients with gastric cancer (operable cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase activity was analyzed. The mean PPA levels in the operable, inoperable and control groups were 45.60 ± 4.20, 54.35 ± 4. 9 and 10.92 ± 0.79 U/l, respectively (p < 0.001). PPA decreased significantly after tumor resection. PPA level was significant in differentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%).


CONCLUSIONS
PPA was significantly higher in patients with inoperable gastric cancer than in operable cases and the control group. A strong correlation was found between tumor volume and PPA.
Department of General Surgery, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Sebahattin
S
Celik
Department of General Surgery, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Remzi
R
Kızıltan
Department of Surgery, Van Training & Education Hospital, Van, Turkey.
Eyüp M
EM
Yılmaz
Department of General Surgery, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Özkan
Ö
Yılmaz
Department of Chemistry, Faculty of Science & Art, Yuzuncu Yıl University, Van, Turkey.
Halit
H
Demir
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D047368:Tumor Burden; D055815:Young Adult
D014408:Biomarkers, Tumor; D004150:Dipeptidases; C022449:proline dipeptidase
enzymes; gastric cancer; prognostic factors; prolidase activity; tumor markers