Associations of objectively measured moderate-to-vigorous-intensity physical activity and sedentary time with all-cause mortality in a population of adults at high risk of type 2 diabetes mellitus.
The relationships of physical activity and sedentary time with all-cause mortality in those at high risk of type 2 diabetes mellitus (T2DM) are unexplored. To address this gap in knowledge, we examined the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with all-cause mortality in a population of adults at high risk of T2DM. In 2010-2011, 712 adults (Leicestershire, U.K.), identified as being at high risk of T2DM, consented to be followed up for mortality. MVPA and sedentary time were assessed by accelerometer; those with valid data (≥ 10 hours of wear-time/day with ≥ 4 days of data) were included. Cox proportional hazards regression models, adjusted for potential confounders, were used to investigate the independent associations of MVPA and sedentary time with all-cause mortality. 683 participants (250 females (36.6%)) were included and during a mean follow-up period of 5.7 years, 26 deaths were registered. Every 10% increase in MVPA time/day was associated with a 5% lower risk of all-cause mortality [Hazard Ratio (HR): 0.95 (95% Confidence Interval (95% CI): 0.91, 0.98); p = 0.004]; indicating that for the average adult in this cohort undertaking approximately 27.5 minutes of MVPA/day, this benefit would be associated with only 2.75 additional minutes of MVPA/day. Conversely, sedentary time showed no association with all-cause mortality [HR (every 10-minute increase in sedentary time/day): 0.99 (95% CI: 0.95, 1.03); p = 0.589]. These data support the importance of MVPA in adults at high risk of T2DM. The association between sedentary time and mortality in this population needs further investigation.
Department of Health Sciences, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care - East Midlands (CLAHRC - EM), Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
Kishan
K
Bakrania
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
Charlotte L
CL
Edwardson
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care - East Midlands (CLAHRC - EM), Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
Kamlesh
K
Khunti
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
Joseph
J
Henson
Charles Perkins Center, Prevention Research Collaboration, School of Public Health, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia; Department of Epidemiology and Public Health, Institute of Epidemiology and Healthcare, University College London, London, WC1E 6BT, United Kingdom.
Emmanuel
E
Stamatakis
National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, United Kingdom.
Mark
M
Hamer
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
Melanie J
MJ
Davies
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
Thomas
T
Yates
Cox proportional hazards regression; Moderate-to-vigorous-intensity physical activity; Mortality; Physical activity; Sedentary; Type 2 diabetes mellitus