The Emerging Role of Non-traditional Ubiquitination in Oncogenic Pathways.
The addition of ubiquitin to a target protein has long been implicated in the process of degradation and is the primary mediator of protein turnover in the cell. Recently, however, many non-proteolytic functions of ubiquitination have emerged as key regulators of cellular homeostasis. In this review, we will describe the various non-traditional functions of ubiquitination, with particular focus on how they can be used as signaling entities in cancer formation and progression. Elaboration of this topic can lead to a better understanding of oncogenic mechanisms, as well as the discovery of novel druggable proteins within the ubiquitin pathway.
From Molecular and Cellular Therapeutics and.
Lisa
L
Dwane
the Cancer Biology and Therapeutics Laboratory, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
William M
WM
Gallagher
the Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland and.
Tríona
T
Ní Chonghaile
From Molecular and Cellular Therapeutics and darranoconnor@rcsi.ie.
Darran P
DP
O'Connor
D000818:Animals; D063646:Carcinogenesis; D002384:Catalysis; D005199:Fanconi Anemia / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006706:Homeostasis; D006801:Humans; D008239:Lysine / Q000737:chemistry; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D009857:Oncogenes; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D059748:Proteolysis; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D025801:Ubiquitin / Q000737:chemistry*; D054875:Ubiquitination
D016328:NF-kappa B; D025801:Ubiquitin; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt; D008239:Lysine
cancer; deubiquitination; deubiquitylation (deubiquitination); monoubiquitination; non-degradative pathways; polyubiquitin chain; signal transduction; therapeutic intervention; ubiquitination; ubiquitylation (ubiquitination)