Protozoan Parasites and Type I IFNs.
For many years, the role of interferon (IFN)-I has been characterized primarily in the context of viral infections. However, regulatory functions mediated by IFN-I have also been described against bacterial infections and in tumor immunology. Only recently, the interest in understanding the immune functions mediated by IFN-I has dramatically increased in the field of protozoan infections. In this review, we discuss the discrete role of IFN-I in the immune response against major protozoan infections:Plasmodium, Leishmania, Trypanosoma, andToxoplasma.
INRS-Institut Armand Frappier, Center for Host-Parasite Interactions , Laval, QC , Canada.
Sasha
S
Silva-Barrios
INRS-Institut Armand Frappier, Center for Host-Parasite Interactions , Laval, QC , Canada.
Simona
S
Stäger
IFN-I; Leishmania; Plasmodium; Toxoplasma; Trypanosoma; protozoan infections