The Virome of the Human Respiratory Tract.
The human respiratory tract virome is defined here as the viruses present in the human respiratory tract that can infect human cells. Sensitive, culture-independent molecular assays (polymerase chain reaction and high-throughput sequencing) reveal that in addition to common viruses that cause acute, symptomatic infections the virome also includes viruses that do not cause clinical symptoms, have unknown pathogenic effect, or cause symptoms but are not among the most common viral respiratory tract pathogens. These molecular tools provide means for better defining the virome and studying the effects of viral infections on the dynamics of chronic lung diseases.
Department of Pediatrics, McDonnell Genome Institute, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address: kwylie@wustl.edu.
Kristine M
KM
Wylie
D002908:Chronic Disease; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000821:virology*; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000821:virology*
Chronic lung disease; Culture independent; Diagnostics; High-throughput sequencing; Infection; Lung; Virus