Phytoalexin Phenalenone Derivatives Inactivate Mosquito Larvae and Root-knot Nematode as Type-II Photosensitizer.
Phytoalexins phenalenones (PNs) are phytochemicals biosynthesized inside the plant in responsive to exterior threat. PNs are excellent type-II photosensitizers, which efficiently produce singlet oxygen upon light irradiation. Based on the core functional structure of PNs, novel PN derivatives were synthesized here and their singlet oxygen generating abilities and their phototoxicity were evaluated. At the presence of light, these PNs have photoinduced toxicity towards Aedes albopictus larvae and nematode Meloidogyne incognita, while the activity lost in the dark. The obvious tissue damage was observed on the treated mosquito larvae and nematode due to the generation of singlet oxygen. Our results revealed the potential of phenalenones as photoactivated agents for mosquito and root-knot nematode management together with light.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Runjiang
R
Song
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Yian
Y
Feng
College of Life Sciences, Peking University, Beijing 100871, China.
Donghui
D
Wang
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Zhiping
Z
Xu
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Zhong
Z
Li
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Xusheng
X
Shao
D000330:Aedes / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007306:Insecticides / Q000138:chemical synthesis / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D008027:Light; D018384:Oxidative Stress; D043803:Phenalenes / Q000138:chemical synthesis / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000819:agonists / Q000378:metabolism; D013329:Structure-Activity Relationship; D014431:Tylenchoidea / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D000094162:Phytoalexins
D000969:Antinematodal Agents; D007306:Insecticides; D043803:Phenalenes; D017319:Photosensitizing Agents; D012717:Sesquiterpenes; D026082:Singlet Oxygen; D000094162:Phytoalexins