A Rare Case of Famotidine-Induced Delirium in a Peritoneal Dialysis Patient.
H2receptor antagonists are commonly employed to manage gastro-esophageal reflux and peptic ulcer diseases with a very low incidence of side effects. Herein, we report an extremely rare incidence of famotidine-induced acute confusion in a patient with end-stage renal failure. We also discuss the pharmacokinetic properties of famotidine and its interplay with compromised renal function to result in neuropsychiatric manifestations, highlighting the importance of dosage ad ustment in individuals with renal insufficiency.
Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong.
Gary C W
GC
Chan
Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong.
K M
KM
Lee
Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong.
Lorraine P Y
LP
Kwan
Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong.
Maggie M Y
MM
Mok
Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong.
Maggie K M
MK
Ma
Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong.
Desmond Y H
DY
Yap
Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong scwtang@hku.hk.
Sydney C W
SC
Tang
D000208:Acute Disease; D003693:Delirium / Q000139:chemically induced* / Q000503:physiopathology; D004415:Dyspepsia / Q000175:diagnosis / Q000188:drug therapy*; D015738:Famotidine / Q000009:adverse effects* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000379:methods; D018570:Risk Assessment; D016896:Treatment Outcome; D028761:Withholding Treatment
D015738:Famotidine
Delirium; H2 receptor antagonists; end-stage renal failure; famotidine; peritoneal dialysis