Statins in conditions other than hypocholesterolemic effects for chronic subdural hematoma therapy, old drug, new tricks?
Chronic subdural hematoma (CSDH) is one of the most common intracranial hematomas worldwide with a high incidence in the general population. However, the optimum treatment for CSDH is Burr-hole drainage with or without rinse Considering the poor outcomes of CSDH in aged patients, and ambiguous prediction of recurrence in many sides of recurrent CSDHs who have been analyzed, new effective therapies are needed for those CSDHs who are predicated to have poor prognosis for surgery and/or have a higher risk of recurrence. Statins, which is the first-line treatment for patients with high cholesterol and coronary heart disease. However, statins are still not solely limited in the treatment of these diseases. It has been demonstrated that statins could improve CSDH due to its effect of regulation of angiogenesis and inflammation. In this review, in order to provide potential new treatment for CSDH we summarize the recent findings of statins in CSDH in order to try to clarify the mechanisms of this effect.
Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Hai
H
Zou
Department of Nephrology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Xing-Xing
XX
Zhu
Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Ya-Hui
YH
Ding
Department of Pharmacy, Zhejiang Provincial People's Hospital, Hangzhou, China.
Guo-Bing
GB
Zhang
Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Yu
Y
Geng
Department of Hepatobiliary Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Dong-Sheng
DS
Huang
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D058492:Drug Repositioning; D066026:Endothelial Progenitor Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D020200:Hematoma, Subdural, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D012038:Regeneration / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D042461:Vascular Endothelial Growth Factor A
chronic subdural hematoma; endothelial progenitor cells; inflammation; statins; vascular endothelial growth factor