Correlation Between Flow-Mediated Dilatation of the Brachial Artery and Serum Endothelial Biomarkers in the Evaluation of Acute Endothelial Injury After Cardiopulmonary Bypass.
OBJECTIVE
The purpose of this study was to investigate the correlation between flow-mediated dilatation of the brachial artery and serum endothelial biomarkers and to discuss the feasibility of sonographic evaluation of acute endothelial injury during cardiopulmonary bypass (CPB) surgery.


METHODS
Sonography was applied to determine the percentage of change in the brachial artery size during flow-mediated dilatation. Meanwhile, the plasma concentrations of endothelial-derived biomarkers, such as endothelin 1, nitric oxide, and von Willebrand factor, were measured to monitor the changes in endothelial function. We analyzed the correlation between flow-mediated dilatation and biomarkers during the perioperative period of CPB in 27 patients.


RESULTS
All of the biomarkers changed dramatically, especially during the CPB period. There was a negative correlation between flow-mediated dilatation and von Willebrand factor (P = .001; R = -0.31).


CONCLUSIONS
A CPB event has a substantial impact on endothelial function, and sonographic assessment of the percentage of change in the brachial artery size during flow-mediated dilatation allows early detection of acute endothelial function injury in cardiac surgery.
Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.|Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Wei-Jian
WJ
Wang
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Jia-Hao
JH
Zhou
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Guo-Liang
GL
He
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Qiao-Lin
QL
Wu
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Wei
W
Gao
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Jie-Hao
JH
Sun
Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Peng-Bo
PB
Zhang
D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000293:injuries* / Q000503:physiopathology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D014463:Ultrasonography; D014841:von Willebrand Factor
D015415:Biomarkers; D019332:Endothelin-1; D014841:von Willebrand Factor; D009569:Nitric Oxide
brachial artery flow-mediated dilatation; cardiopulmonary bypass; endothelial function; sonography; vascular ultrasound