The pro- or antiarrhythmic actions of polyunsaturated fatty acids and of cholesterol.
In this review, the pro- and anti-arrhythmic effects of a diet rich in fish oil fatty acids and of hypercholesterolemia will be discussed in relation to two major mechanisms of arrhythmogenesis (triggered activity and re-entry). Whereas a diet rich in fish oil is pro-arrhythmic in relation to re-entry based arrhythmias (as occur in acute myocardial ischemia) and anti-arrhythmic in relation to triggered activity based arrhythmias (as occur in heart failure), the reverse is true for hypercholesterolemia. Changing the lipid composition of cardiomyocytes likely has powerful pro- or anti-arrhythmic consequences, depending on the mechanism of arrhythmias, and has corresponding therapeutic potential.
Dept. Exp. Cardiology, Academic Medical Center, Amsterdam, The Netherlands; IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, F-33600 Pessac Bordeaux, France. Electronic address: rubencoronel@gmail.com.
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D000818:Animals; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology*; D002784:Cholesterol / Q000097:blood / Q000502:physiology*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans
D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D002784:Cholesterol
Antiarrhythmic strategies; Cardiac arrhythmias; Cholesterol; Fish oil; PUFA