Research of the relationship between β-catenin and c-myc-mediated Wnt pathway and laterally spreading tumors occurrence.
We studied the relationship between the occurrence of laterally spreading tumors (LSTs) and the activation of Wnt/β-catenin/c-myc pathway.



20 cases of colorectal polypoid adenomas (PAs) tissue sample, 20 cases of LSTs tissue sample and 20 cases of colorectal cancer tissue sample were acquired, and positive expression of Wnt/β-catenin/c-myc proteins were detected by immunohistochemical staining. In addition, relative expression levels of mRNA and protein were measured using RT-PCR and Western blotting method.



The positive expression levels of Wnt/β-catenin/c-myc protein in the colorectal cancer group were higher than that in LST group, and the value of the PAs group was the lowest; differences were statistically significant (p < 0.05). The relative expression levels of Wnt/β-catenin/c-myc mRNA and protein in colorectal cancer group were higher than that in LST group, and the value of PAs group was the lowest; differences were statistically significant (p < 0.05).



The activation level of the Wnt/β-catenin/c-myc pathway has a close relation to the occurrence and deterioration of LSTs.
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou China. eql9688767@163.com.
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D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism*
C495270:CTNNB1 protein, human; D016271:Proto-Oncogene Proteins c-myc; D051153:Wnt Proteins; D051176:beta Catenin