CATH-Gene3D: Generation of the Resource and Its Use in Obtaining Structural and Functional Annotations for Protein Sequences.
This chapter describes the generation of the data in the CATH-Gene3D online resource and how it can be used to study protein domains and their evolutionary relationships. Methods will be presented for: comparing protein structures, recognizing homologs, predicting domain structures within protein sequences, and subclassifying superfamilies into functionally pure families, together with a guide on using the webpages.
Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK. natalie.dawson.09@ucl.ac.uk.
Natalie L
NL
Dawson
Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Ian
I
Sillitoe
Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Jonathan G
JG
Lees
Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.|School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.
Su Datt
SD
Lam
Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Christine A
CA
Orengo
D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D008958:Models, Molecular; D058977:Molecular Sequence Annotation; D011485:Protein Binding; D011487:Protein Conformation; D054730:Protein Interaction Domains and Motifs; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D012984:Software; D013329:Structure-Activity Relationship; D064878:Web Browser; D057188:Workflow
D011506:Proteins
Annotation; Classification; Database; Function prediction; Protein domain; Sequence; Structural model prediction; Structure