Evaluation of the severity of ulcerative colitis using endoscopic dual red imaging targeting deep vessels.
Background and study aimsColonoscopies can predict long-term prognoses in patients with ulcerative colitis (UC). Recently, a new imaging technology has been developed that uses 3 types of illumination with center wavelengths of 540 nm, 600 nm, and 630 nm. The use of both the 600-nm and 630-nm lights (Dual red imaging; DRI) is critical for identifying blood vessels in deeper tissue. The aim of this study was to evaluate the usefulness of DRI for assessing the severity of inflammation in patients with UC.Patients and methodsA total of 43 UC patients were retrospectively enrolled to evaluate the endoscopic severity of 112 colon segments, and Mayo endoscopic scores, DRI scores and the severity of inflammation on a visual analogue scale (VAS) were compared. The Mayo endoscopic scores, DRI scores, and histologic scores were evaluated, and the interobserver agreement on DRI scores among 5 investigators was also assessed. The usefulness of DRI scores for predicting prognoses was also assessed in patients with clinical remission.ResultsThe DRI scores were closely correlated with the VAS for the severity of colonic inflammation (r = 0.96) and the histologic scores (r = 0.72 - 0.8). The DRI scores had a higher rate of interobserver agreement (κ values = 0.63 - 0.88) than the Mayo endoscopic scores (κ values = 0.44 - 0.59). Inter-observer agreement between 4 non-experts was also excellent (mean κ value = 0.76, range 0.63 - 0.82). The expected time until recurrence was significantly longer in patients with lower DRI scores (P< 0.01).ConclusionDRI can be used in patients with mild to moderate endoscopic severity because it targets the deep vascular pattern. The prognosis of UC can be predicted by assessing deep vessels using DRI.
Department of Gastroenterology and Hepatology, Keio University, Tokyo, Japan; Center for Diagnostic and Therapeutic Endoscopy, Keio University, Tokyo, Japan.
Makoto
M
Naganuma
Cancer Center, Keio University, Tokyo, Japan.
Naohisa
N
Yahagi
Department of Gastroenterology and Hepatology, Keio University, Tokyo, Japan.
Rieko
R
Bessho
Department of Gastroenterology and Hepatology, Keio University, Tokyo, Japan.
Keiko
K
Ohno
Department of Gastroenterology and Hepatology, Keio University, Tokyo, Japan.
Mari
M
Arai
Department of Gastroenterology and Hepatology, Keio University, Tokyo, Japan.
Makoto
M
Mutaguchi
Department of Gastroenterology and Hepatology, Keio University, Tokyo, Japan.
Shinta
S
Mizuno
Cancer Center, Keio University, Tokyo, Japan.
Ai
A
Fujimoto
Cancer Center, Keio University, Tokyo, Japan.
Toshio
T
Uraoka
Division of Diagnostic Pathology, Keio University, Tokyo, Japan.
Masayuki
M
Shimoda
Center for Diagnostic and Therapeutic Endoscopy, Keio University, Tokyo, Japan.
Naoki
N
Hosoe
Cancer Center, Keio University, Tokyo, Japan.
Haruhiko
H
Ogata
Department of Gastroenterology and Hepatology, Keio University, Tokyo, Japan.
Takanori
T
Kanai