Sub-10 nm Sr2LuF7:Yb/Er@Sr2GdF7@SrF2Up-Conversion Nanocrystals for Up-Conversion Luminescence-Magnetic Resonance-Computed Tomography Trimodal Bioimaging.
Herein, sub-10 nm core-shell nanocrystals (NCs), which select Sr2LuF7:Yb/Er as core, Sr2GdF7as middle shell, and SrF2as an outermost shell, were synthesized by a seed-mediated growth process. The NCs possess good crystallinity, morphology, and up-conversion luminescent properties. After modification by polyethylenimine branched (PEI), in vitro cell up-conversion imaging with low autofluorescence was realized. Due to the presence of Gd3+ions, in vivo magnetic resonance (MR) imaging was also achieved with these designed NCs. More significantly, these special core-shell NCs exhibited high contrast in in vivo X-ray computed tomography (CT) imaging because of their good X-ray absorption ability. These results indicate that the core-shell up-conversion NCs can serve as promising contrast agents for up-conversion luminescence-MR-CT trimodal bioimaging.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.
Cailing
C
Chen
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.|Department of Radiology, The Second Hospital of Jilin University , Changchun 130022, P.R. China.
Jianhua
J
Liu
Department of Obstetrics, First Hospital of Jilin University , 71 Xinmin Street, Changchun 130021, China.
Ying
Y
Chen
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.
Chunguang
C
Li
State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences , Changchun 130012, P.R. China.
Xiaomin
X
Liu
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.
He
H
Huang
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.
Chen
C
Liang
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.
Yue
Y
Lou
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.
Zhan
http://orcid.org/0000-0001-9717-1487
Z
Shi
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012, P.R. China.
Shouhua
S
Feng
D049449:Luminescence; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles; D014057:Tomography, X-Ray Computed
core−shell; muti-modal bioimaging; nanocrystal; rare earth; up-conversion