Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging.
Magnetic particle imaging (MPI) is an emerging tracer-based medical imaging modality that images non-radioactive, kidney-safe superparamagnetic iron oxide (SPIO) tracers. MPI offers quantitative, high-contrast and high-SNR images, so MPI has exceptional promise for applications such as cell tracking, angiography, brain perfusion, cancer detection, traumatic brain injury and pulmonary imaging. In assessing MPI's utility for applications mentioned above, it is important to be able to assess tracer short-term biodistribution as well as long-term clearance from the body. Here, we describe the biodistribution and clearance for two commonly used tracers in MPI: Ferucarbotran (Meito Sangyo Co., Japan) and LS-oo8 (LodeSpin Labs, Seattle, WA). We successfully demonstrate that 3D MPI is able to quantitatively assess short-term biodistribution, as well as long-term tracking and clearance of these tracers in vivo.
Department of Bioengineering, University of California Berkeley, Berkeley CA 94720, United States of America.
Paul
P
Keselman
Elaine Y
EY
Yu
Xinyi Y
XY
Zhou
Patrick W
PW
Goodwill
Prashant
P
Chandrasekharan
R Matthew
RM
Ferguson
Amit P
AP
Khandhar
Scott J
SJ
Kemp
Kannan M
KM
Krishnan
Bo
B
Zheng
Steven M
SM
Conolly
D000818:Animals; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008657:Metabolic Clearance Rate; D057054:Molecular Imaging / Q000379:methods*; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D058185:Magnetite Nanoparticles