Risk factors associated with sexually transmitted infections among HIV infected men who have sex with men.
To investigate the factors associated with sexually transmitted infection and Human Immunodeficiency Virus (STI-HIV) co-infection among men who have sex with men (MSM). A total of 357 HIV-infected participants (84 STI-HIV co-infection and 273 HIV infections only) were recruited from Jiangsu, China. Logistic regression analyses were used to estimate the related factors associated with STI-HIV co-infection. Marginal structural models were adopted to estimate the effect of transmission drug resistance (TDR) on STI-HIV co-infection. For all participants, logistic regression analyses revealed that those who diagnosed with HIV-1 for longer duration (≥1.8 years) were significantly associated with reduced STI-HIV co-infection risk (OR = 0.55, 95%CI: 0.32-0.96, P = 0.036). In further stratification analysis by antiretroviral therapy (ART), individuals with longer duration showed consistent significant associations with STI-HIV co-infection risk (OR = 0.46, 95%CI: 0.26-0.83, P = 0.010) among MSM with ART-naïve status. In addition, significant reduced risk for STI-HIV co-infection (OR = 0.98, 95%CI: 0.96-0.99, P = 0.010) were observed in younger (under the average age of 31.03) MSM of the same group. Interestingly, we also found TDR was significantly associated with an increased risk of STI-HIV co-infection risk (OR = 3.84, 95%CI: 1.05-14.03, P = 0.042) in ART-naïve group. Our study highlights a pattern of STI-HIV co-infection among MSM in China and indicates that targeted interventions aimed at encouraging TDR monitoring in MSM with early HIV infection are warranted.
Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong City, Jiangsu Province, China.
Yun
Y
Xian
Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong City, Jiangsu Province, China.
Bowen
B
Zhu
Wuxi Centre for Disease Control and Prevention, Wuxi City, Jiangsu Province, China.
Xuan
X
Zhang
Nantong Centre for Disease Control and Prevention, Nantong City, Jiangsu Province, China.
Ping
P
Ma
Nantong Centre for Disease Control and Prevention, Nantong City, Jiangsu Province, China.
Ye
Y
Wei
Nantong Centre for Disease Control and Prevention, Nantong City, Jiangsu Province, China.
Hongli
H
Xia
Department of Management Studies, University of Bath, Bath City, United Kingdom.
Wenjie
W
Jiang
Yancheng Centre for Disease Control and Prevention, Yancheng City, Jiangsu Province, China.
Changqing
C
Yang
Wuxi Centre for Disease Control and Prevention, Wuxi City, Jiangsu Province, China.
Xiaojun
X
Meng
Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong City, Jiangsu Province, China.
Peng
P
Peng
Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong City, Jiangsu Province, China.
Yue
Y
Yang
Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong City, Jiangsu Province, China.
Liying
L
Jiang
Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong City, Jiangsu Province, China.
Minjie
M
Chu
Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong City, Jiangsu Province, China.
Xun
X
Zhuang
D000328:Adult; D002681:China; D060085:Coinfection / Q000453:epidemiology / Q000635:transmission; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission*; D018451:Homosexuality, Male / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D012307:Risk Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data; D012749:Sexually Transmitted Diseases / Q000453:epidemiology* / Q000635:transmission*