Enantioseparation of isoxazolines with functionalized perphenylcarbamate cyclodextrin clicked chiral stationary phases in HPLC.
The enantioseparations of 12 isoxazoline racemates were explored with four perphenylcarbamate cyclodextrin (CD) clicked chiral stationary phases (CSPs) in high performance liquid chromatography (HPLC). The results demonstrated that the functionalities on phenylcarbamate moiety greatly determined the chiral separation ability of CD clicked CSPs. Among of them, per(3-chloro-4-methylphenylcarbamate) CD clicked CSP (CCC3M4-CSP) exhibited the best enantioseparation ability, affording 4ClPh-OPr with a chiral resolution over 20 in ternary eluent mobile phases. The optimization of CSPs structures provided wide platform for their chiral separations towards multi-mode HPLC.
Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing, P. R. China.
Bo
B
Yang
Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing, P. R. China.
Jie
J
Zhou
Department of Chemistry, School of Science, Tianjin University, Tianjin, P. R. China.
Yong
Y
Wang
Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing, P. R. China.
Jian
J
Tang
Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing, P. R. China.
Weihua
W
Tang
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D007555:Isoxazoles / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D048448:Phenylcarbamates / Q000737:chemistry*; D013237:Stereoisomerism
D003505:Cyclodextrins; D007555:Isoxazoles; D048448:Phenylcarbamates
Chiral stationary phase; Enantioseparation; High performance liquid chromatography; Isoxazoline; Phenylcarbamate cyclodextrin