Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases.
MicroRNAs (miRNAs and miRs) are a large class of noncoding, single-stranded, small RNA molecules. The precise control of their expression is essential for keeping tissue homeostasis and normal development of organisms. Thus, unbalanced expression of miRNAs is a hallmark of many diseases. Two to dozens of miRNAs can form into a miRNA cluster, and the miR-17-92 cluster is one of them. Although firstly described as an oncogenic miRNA cluster, the miR-17-92 cluster has also been found to play critical role in normal cardiac development and cardiovascular disease. This review focuses on the characteristics and functions of miR-17-92 cluster in heart.
Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Huanyu
H
Gu
Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Zhuyuan
Z
Liu
Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Lei
0000-0002-5985-3177
L
Zhou
D002318:Cardiovascular Diseases / Q000235:genetics*; D002319:Cardiovascular System / Q000254:growth & development* / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D005810:Multigene Family
D035683:MicroRNAs