Exploration of Various Proteins for the Treatment of Alzheimer's Disease.
BACKGROUND
Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. It is the most frequent cause of memory loss and dementia in elderly individuals worldwide. The extracellular deposition of beta amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) retention, neuronal decline and neurotransmitter system derangement are the patho-physiological marker of this devastated disease Objective: In view of limited treatment option and their success rate, there is an urgent need to explore the vast array of proteomes for the management of AD. These proteins could be therapeutically targeted to prevent the progression of this disease. In the present review, we tried to uncover several proteins that could be exploited in AD therapeutics.


CONCLUSIONS
Based on our article, we conclude that proteome based AD treatment needs more refinements and approaches to achieve the desired success rate.
Department of Biochemistry, J. N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002. India.
Badar Ul
BU
Islam
Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589. Saudi Arabia.
Syed Kashif
SK
Zaidi
King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589. Saudi Arabia.
Mohammad Amjad
MA
Kamal
King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589. Saudi Arabia.
Shams
S
Tabrez
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D006801:Humans; D016875:tau Proteins / Q000378:metabolism*
D016564:Amyloid beta-Protein Precursor; D016875:tau Proteins
Alzheimer's disease; amyloid beta; amyloid precursor protein; apolipoprotein; tau; therapeutics