Biomarkers of oxidative stress in pregnancy complications.
Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation. This review discusses the detection of oxidative stress markers in biological fluids and highlights the need for further studies to validate their use in the prediction or diagnosis of pregnancy disorders.
School of Medical Science & Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
James Sm
JS
Cuffe
School of Medical Science & Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Ziheng Calvin
ZC
Xu
School of Medical Science & Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Anthony V
AV
Perkins
D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers / Q000097:blood* / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications; D050050:Protein Carbonylation; D014443:Tyrosine / Q000031:analogs & derivatives / Q000097:blood
D015415:Biomarkers; D017127:Glycation End Products, Advanced; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; C002744:3-nitrotyrosine; D014443:Tyrosine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
GDM; IUGR; pre-eclampsia; preterm birth; reactive oxygen species