Octogenarian donors in liver transplantation grant an equivalent perioperative course to ideal young donors.
BACKGROUND
Use of grafts from very old donors for liver transplantation is controversial.


OBJECTIVE
To compare the perioperative course of patients receiving liver grafts from young ideal vs octogenarian donors.


METHODS
Analysis of the perioperative course of patients receiving liver grafts from young, ideal (18-39 years) vs octogenarian (≥80years) deceased donors between 2001 and 2014.


RESULTS
346 patients were studied: 179 (51.7%) received grafts aged 18-39 years whereas 167 (48.3%) received a graft from a donor aged ≥80years. Intra-operative cardiovascular (p=0.2), coagulopathy (p=0.5) and respiratory (p=1.0) complications and incidence of reperfusion syndrome (p=0.3) were similar. Patients receiving a young graft required more fresh frozen plasma units (p≤0.03) but did not differ for the need of packed red cells (p=0.2) and platelet (p=0.3) transfusions. Median ICU stay was identical (p=0.4). Patients receiving octogenarian vs young grafts did not differ in terms of death or re-transplant (p=1.0) during the ICU stay. Similar cardiovascular, respiratory, renal, infectious and neurological postoperative complication rates were observed in the two groups.


CONCLUSIONS
Octogenarian donors in liver transplantation grant an equivalent perioperative course to ideal young donors.
Anaesthesia and Critical Care for General and Transplantation Surgery, Azienda Ospedaliera-Universitaria Pisana, Italy. Electronic address: g.biancofiore@med.unipi.it.
Gianni
G
Biancofiore
Anaesthesia and Critical Care for General and Transplantation Surgery, Azienda Ospedaliera-Universitaria Pisana, Italy.
Maria
M
Bindi
Hepatobiliary and Liver Transplant Surgery, University School of Medicine, Pisa, Italy.
Davide
D
Ghinolfi
Hepatobiliary and Liver Transplant Surgery, University School of Medicine, Pisa, Italy.
Quirino
Q
Lai
Anaesthesia and Critical Care for General and Transplantation Surgery, Azienda Ospedaliera-Universitaria Pisana, Italy.
Massimo
M
Bisa
Anaesthesia and Critical Care for General and Transplantation Surgery, Azienda Ospedaliera-Universitaria Pisana, Italy.
Massimo
M
Esposito
Anaesthesia and Critical Care for General and Transplantation Surgery, Azienda Ospedaliera-Universitaria Pisana, Italy.
Luca
L
Meacci
Anaesthesia and Critical Care for General and Transplantation Surgery, Azienda Ospedaliera-Universitaria Pisana, Italy.
Roberto
R
Mozzo
Anaesthesia and Critical Care for General and Transplantation Surgery, Azienda Ospedaliera-Universitaria Pisana, Italy.
Alicia
A
Spelta
Hepatobiliary and Liver Transplant Surgery, University School of Medicine, Pisa, Italy.
Franco
F
Filipponi
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000369:Aged, 80 and over; D001803:Blood Transfusion; D016208:Databases, Factual; D046148:Donor Selection / Q000592:standards*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007558:Italy; D016031:Liver Transplantation; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D019990:Perioperative Care; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
Organ donation; Organ transplantation; Perioperative care