Inflammation, metaflammation and immunometabolic disorders.
Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.
Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Broad Institute of Harvard and MIT, Boston, Massachusetts 02115, USA.
Gökhan S
GS
Hotamisligil
D056704:Adaptive Immunity / Q000235:genetics; D000818:Animals; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000378:metabolism; D019143:Evolution, Molecular; D055106:Genome-Wide Association Study; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D007448:Invertebrates / Q000276:immunology / Q000378:metabolism; D008659:Metabolic Diseases / Q000150:complications / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D015398:Signal Transduction
D016207:Cytokines; D006728:Hormones