Evaluation of plasma oxidative stress, with or without antioxidant supplementation, in superficial partial thickness burn patients: a pilot study.
BACKGROUND
Oxidative stress is one of the main causes of pathophysiological alterations observed during burn injury. The present pilot study aimed to determine whether a specific oral antioxidant supplementation could in any way influence free radical blood values in patients affected by superficial partial thickness burns.


METHODS
Plasma oxidants and plasma antioxidant capacity were analysed in 20 superficial partial thickness burn patients for a 2-week period; patients were randomly divided into two groups, one of which was supported with a specifically designed oral antioxidant formula (Squalene 100 mg, Vitamin C 30 mg, Coenzyme Q10 10 mg, Zinc 5 mg, Beta Carotene 3.6 mg, Bioflavonoids 30 mg, Selenium 55 mcg) administered daily, starting from the day of admission, for the whole study period.


RESULTS
No significant differences were found in plasma oxidants and plasma antioxidant capacity between the two groups of patients.


CONCLUSIONS
These results did not reflect any significant benefits of an antioxidant oral supplementation at usual dosages when considering oxidative plasmatic values of superficial partial thickness burn patients.
a The Plastic Surgery Clinic, Department of Surgical Sciences , University of Parma , Parma , Italy.
Edoardo
E
Raposio
a The Plastic Surgery Clinic, Department of Surgical Sciences , University of Parma , Parma , Italy.
Michele P
MP
Grieco
b The Plastic Surgery and Burns Centre , University Hospital , Parma , Italy.
Edoardo
E
Caleffi
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism*; D004338:Drug Combinations; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010865:Pilot Projects; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use; D055815:Young Adult; D019207:beta Carotene / Q000627:therapeutic use
D000975:Antioxidants; D004338:Drug Combinations; D005419:Flavonoids; D005609:Free Radicals; D019207:beta Carotene; D014451:Ubiquinone; C024989:coenzyme Q10; D001205:Ascorbic Acid
Burns; antioxidants; oxidative stress