[Expression of long non-coding RNA SNHG8 in Epstein-Barr virus-related gastric cancer and clinical outcome].
Objective:To investigate the expression of long non-coding RNA (lncRNA) SNHG8 in EB virus related gastric cancer and their correlation prognosis.Methods:The expression of SNHG8 in 93 gastric cancers and 93 cancer-free controls, matched by age and sex, were determined by real-time PCR. EB virus expression was detected by EBER in situ hybridization.Results:Forty-one gastric cancers were EB virus associated. For all gastric cancers, SNHG8 expression was 14 times higher (P=0.001) than that in non-cancer controls; in the EB virus related gastric cancers, SNHG8 expression was increased 25 times (P<0.05) over EB virus negative gastric cancers. SNHG8 expression level was also significantly associated with TNM staging (P<0.05).Conclusions:SNHG8 may act as a proto-oncogene, participating in gastric carcinogenesis.EB virus infection of gastric mucosa may promote SNHG8 expression.
Department of Molecular Pathology, Fujian Provincial Cancer Hospital, Fuzhou 350014, China.
B Z
BZ
Chen
X D
XD
Lin
G
G
Chen
D
D
Hu
Q
Q
Zhu
Y
Y
Shi
X J
XJ
Wang
S F
SF
Jin
H F
HF
Wang
X W
XW
Zheng
D016022:Case-Control Studies; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000378:metabolism; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D062085:RNA, Long Noncoding / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology*
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D062085:RNA, Long Noncoding; D012367:RNA, Viral
Herpesvirus 4, human; Long-non-coding RNA; Stomach neoplasms