Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis.
ADIPOQ gene polymorphisms have been indicated to be associated with hypertension; however, published studies have reported inconsistent results. Eligible studies were retrieved by searching the PubMed, Embase and China National Knowledge Infrastructure databases. The case group consisted of patients with hypertension, and the control group consisted of subjects with normal blood pressure. Based on eleven published articles, involving 4837 cases and 5618 controls, the pooled results from rs2241766 polymorphism showed increased risk in the allelic model (G VS T: OR = 1.16, 95%CI = 1.06-1.27), recessive model (GG VS GT + TT: OR = 1.34, 95%CI = 1.10-1.63), dominant model (GG + GT VS TT: OR = 1.15, 95%CI = 1.02-1.30) and homozygote model (GG VS TT: OR = 1.38, 95%CI = 1.21-1.69). In addition, rs266729 polymorphism showed increased risk for hypertension in the recessive model (GG VS GC + CC: OR = 1.43, 95%CI = 1.02-2.01). In the Caucasian subgroup, rs1501299 polymorphism showed decreased risk of hypertension in the allelic model (T VS G: OR = 0.75, 95%CI = 0.58-0.97), dominant model (TT + TG VS GG: OR = 0.83, 95%CI = 0.71-0.98) and heterozygote model (TG VS GG: OR = 0.82, 95%CI = 0.68-0.99). The rs2241766 polymorphism was associated with a significant increase in hypertension risk based on our analysis. Moreover, an increased risk of rs266729 in hypertension patients was also detected. Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in hypertension in Caucasian subgroup; however, this finding requires further study.
Department of Cardiology, Centre Hospital of Xianyang, Xianyang 712000, People's Republic of China.
Weina
W
Fan
Department of Clinical Laboratory, The Affiliated Hospital of Yan'an University, Yan'an University, Yan'an 71600, People's Republic of China.
Xiaowei
X
Qu
Department of Infection, Renmin Hospital of Yan'an, Yan'an 716000, People's Republic of China.
Jing
J
Li
Department of Clinical Laboratory, The Affiliated Hospital of Yan'an University, Yan'an University, Yan'an 71600, People's Republic of China.
Xingning
X
Wang
Department of Cardiology, Affiliated Hospital of Yan'an University, Yan'an University, Yan'an 71600, People's Republic of China.
Yanping
Y
Bai
Department of Clinical Laboratory, The Affiliated Hospital of Yan'an University, Yan'an University, Yan'an 71600, People's Republic of China.
Qingmei
Q
Cao
Department of Nephropathy, 2nd Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an 710004, People's Republic of China.
Liqun
L
Ma
Department of Invasive Technology, Traditional Chinese Medicine hospital of Shanxi, Xi'an 710003, People's Republic of China.
Xiaoyao
X
Zhou
Department of Clinical laboratory, Centre hospital of Baoji, Baoji 721008, People's Republic of China.
Wei
W
Zhu
Department of Cardiology, Affiliated Hospital of Yan'an University, Yan'an University, Yan'an 71600, People's Republic of China.
Wei
W
Liu
Department of Vascular Disease and Hypertension, Peripheral Vascular, 1st Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, People's Republic of China.
Qiang
Q
Ma
D052242:Adiponectin / Q000235:genetics*; D000483:Alleles; D005787:Gene Frequency; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D018570:Risk Assessment; D012307:Risk Factors; D044465:White People / Q000235:genetics
C499918:ADIPOQ protein, human; D052242:Adiponectin