Sex differences in the psychopharmacological treatment of depression.
Although a number of studies have observed that females respond better to serotonergic antidepressants than males and that postmenopausal females have a diminished response to antidepressants compared with younger females, there are also studies that conflict with both of these findings, making any generalizations regarding sex differences difficult to make. Sex variance in antidepressant efficacy and pharmacokinetics profiles have been attributed to sex-based physiological differences, behavioral differences, related disorders, and sex-specific conditions, including pregnancy and menopause. This paper will review the history and current research on sex effects of antidepressant treatment.
Worldwide Clinical Trials, Beverly Hills, California, USA.
John J
JJ
Sramek
Worldwide Clinical Trials, King of Prussia, Pennsylvania, USA.
Michael F
MF
Murphy
Worldwide Clinical Trials, Beverly Hills, California, USA.
Neal R
NR
Cutler
D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D003863:Depression / Q000503:physiopathology* / Q000628:therapy*; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000628:therapy*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D012727:Sex Characteristics
D000928:Antidepressive Agents
SSRi; antidepressant; depression; efficacy; estrogen; hormone; menopause; pharmacokinetics; sex