Concise Review: Hematopoietic Stem Cell Origins: Lessons from Embryogenesis for Improving Regenerative Medicine.
Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone marrow transplantation. Finding appropriate donors remains a major limitation to more extensive usage of HSC-based therapies. Derivation of patient-specific HSCs from pluripotent stem cells offers great promise to remedy this problem if scientists could crack the code on how to make robust, transplantable HSCs in a dish. Studies delving into the native origins of HSC production during embryonic development should supply the necessary playbook. This review presents recent discoveries from animal models, with a focus on zebrafish, and discusses the implications of these new advances in the context of prior knowledge. The focus is on the latest research exploring the role of epigenetic regulation, signaling pathways, and niche components needed for proper HSC formation. These studies provide new directions that should be explored for de novo generation and expansion of HSCs for regenerative therapies. Stem Cells Translational Medicine 2017;6:60-67.
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.|Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Adriana
A
De La Garza
Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Bronx, New York, USA.
Arpan
A
Sinha
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.|Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.|Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, New York, USA.
Teresa V
TV
Bowman
D000818:Animals; D019070:Cell Lineage; D047108:Embryonic Development; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D051880:Receptors, Notch / Q000378:metabolism; D044968:Regenerative Medicine
D051880:Receptors, Notch
Bone marrow transplant; Developmental biology; Embryo; Hematopoietic stem cells