E-cadherin and β-catenin immunoexpression in endometrioid endometrial carcinoma.
E-cadherin and β-catenin are two molecules implicated in cellular adhesion. The reduced expression of β-catenin and E-cadherin is associated with the tumoral epithelial-mesenchymal transition process, a key event in the development of endometrial carcinoma. The aim of our study was to investigate the association between the immunoexpression of β-catenin÷E-cadherin and the tumor differentiation degree, presence of lymph nodes, depth of tumor invasion and pTNM stage of endometrioid endometrial carcinomas in order to enhance the potential aggressiveness of these tumors. Our results revealed significant differences in the expression of β-catenin, when grouping for the tumor stage, invasion in the myometrium and degree of differentiation, as well as significant differences in the expression of E-cadherin for tumor degrees of differentiation. E-cadherin and β-catenin expression was stronger in well-differentiated tumors, superficial myometrium invasion and early tumor stages I or II, thus was associated with better prognostic forms of endometrioid endometrial carcinoma. Our study indicated that decreased of the E-cadherin and β-catenin expression is useful for the assessment of tumor aggressivity.
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania; stefania.tudorache@gmail.com.
Mirela Marinela
MM
Florescu
Daniel
D
Pirici
Cristiana Eugenia
CE
Simionescu
Alex Emilian
AE
Stepan
Claudiu
C
Mărgăritescu
Ştefania
Ş
Tudorache
Raluca Niculina
RN
Ciurea
D015820:Cadherins / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000235:genetics* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011379:Prognosis
D015820:Cadherins