Acute and Late Bartonella henselae Murine Model Infection.
Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice by using molecular tests and confocal microscopy to demonstrate Bartonella henselae infection in the bloodstream and organs after 4 and 21 days of intraperitoneally injected bacterial suspension. We demonstrate that the occurrence of infection in organs precedes the detectable infection in blood. Therefore, late manifestation in blood may be another challenge in early detection and diagnosis of B. henselae infection.
1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
Marilene Neves
MN
da Silva
1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .|2 Federal Institute of Education , Science and Technology, São Paulo, Brazil .
Gislaine
G
Vieira-Damiani
3 Department of Dermatology, University of Minnesota Medical School , Minneapolis, Minnesota.
Marna Elise
ME
Ericson
4 Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical School , Minneapolis, Minnesota.
Kalpna
K
Gupta
1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
Amanda Roberta
AR
de Almeida
1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
Marina Rovani
MR
Drummond
1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
Tania Cristina Benetti
TC
Soares
1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
Bruno Grosselli
BG
Lania
5 Laboratory of Animal Quality Control, Multidisciplinary Center of Biological Investigation (CEMIB), University of Campinas (UNICAMP) , Campinas, Brazil .
Rovilson
R
Gilioli
1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
Paulo Eduardo Neves Ferreira
PE
Velho
D000818:Animals; D016470:Bacteremia; D001474:Bartonella Infections / Q000097:blood / Q000382:microbiology* / Q000473:pathology*; D018416:Bartonella henselae / Q000472:pathogenicity*; D008099:Liver / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D012867:Skin / Q000382:microbiology; D013154:Spleen / Q000382:microbiology; D013997:Time Factors
Bartonella; diagnosis; vector-borne; zoonotic