Graphene oxide and creatine phosphate disodium dual template-directed synthesis of GO/hydroxyapatite and its application in drug delivery.
In this study, graphene oxide and creatine phosphate disodium acted as dual template and was employed to synthesize graphene oxide (GO)/hydroxyapatite (HA) hybrids as drug carriers. In the rapid preparation of GO/HA hybrids, creatine phosphate disodium salt (CPDS) severed as a phosphorus source and graphene oxide acted as a template in aqueous solution. The effects of the reaction temperature, time and pH value of the aqueous solution on the morphology of the product were investigated. The result showed that the hydrolysis of CPDS under hydrothermal condition played an important role in the formation of hierarchical hollow GO/HA hybrids. The GO nanosheets provided reactive sites for the binding of HA nanoparticles and absorbing ibuprofen (IBU) molecules. The GO/HA hybrids had ideal sustained drug-release behavior. It indicated that the prepared GO/HA hybrids may be promising materials for applications in biomedical area.
School of Chemistry and Chemical Engineering, Anhui University, Anhui 230601, PR China; School of Chemistry and Chemical Engineering, Hefei Normal University, Anhui 230601, PR China.
Chengli
C
Yao
School of Chemistry and Chemical Engineering, Hefei Normal University, Anhui 230601, PR China.
Jinmiao
J
Zhu
School of Chemistry and Chemical Engineering, Anhui University, Anhui 230601, PR China. Electronic address: anjx@163.com.
Anjian
A
Xie
School of Chemistry and Chemical Engineering, Anhui University, Anhui 230601, PR China.
Yuhua
Y
Shen
School of Chemistry and Chemical Engineering, Hefei Normal University, Anhui 230601, PR China.
Hongying
H
Li
School of Chemistry and Chemical Engineering, Hefei Normal University, Anhui 230601, PR China.
Bin
B
Zheng
School of Chemistry and Chemical Engineering, Hefei Normal University, Anhui 230601, PR China.
Yanxin
Y
Wei
D000327:Adsorption; D016503:Drug Delivery Systems / Q000379:methods*; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry; D006108:Graphite / Q000138:chemical synthesis* / Q000737:chemistry; D007052:Ibuprofen / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D010725:Phosphocreatine / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
D010725:Phosphocreatine; D006108:Graphite; D017886:Durapatite; D007052:Ibuprofen
Drug delivery; Graphene oxide; Hybrid material; Hydroxyapatite; Template