Resilience to traumatic events related to urban violence and increased IL10 serum levels.
The exposition to traumatic events related to urban violence is epidemic in Brazil, with rate of 80% in the general population, and is becoming a major cause of post-traumatic stress disorder (PTSD). The objective of the study was to compare serum levels of pro-inflammatory interleukin-6 (IL-6) and anti-inflammatory interleukin-10 (IL-10) in PTSD and resilient individuals. We hypothesized that resilient individuals present an attenuated pro-inflammatory and enhanced anti-inflammatory state. We conducted a case-control study comparing 30 resilient individuals and 30 PTSD patients exposed to traumatic events related to urban violence. The groups were evaluated using Self-Report Questionnaire (SRQ-20), Mini-International Neuropsychiatric Interview (MINI) and the Davidson Trauma Scale. For all individuals, blood samples were collected to determine IL-6, IL-10 and cortisol serum levels. All samples were frozen at -80°C until the assay and were analyzed with the same immunoassay kit and in duplicates. The resilient group presented higher IL-10 levels than PTSD patients [mean (CI95%); 1.03 (0.52-2.08) pg/mL vs. 0.29 (0.20-0.43) pg/mL; P=0.002]. There were no differences in terms of IL-6 or cortisol levels. The results provided evidence for increased levels of IL-10 in resilient individuals when compared to PTSD patients, probably conferring them a better anti-inflammatory response after exposition.
Post-Graduate Program in Psychiatry and Behavioral Sciences, Federal University at Rio Grande do Sul, Brazil; PTSD Outpatient program (NET-Trauma), Hospital de Clínicas de Porto Alegre, Brazil.
Stefania P
SP
Teche
Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Diego L
DL
Rovaris
Post-Graduate Program in Psychiatry and Behavioral Sciences, Federal University at Rio Grande do Sul, Brazil.
Bianca W
BW
Aguiar
Department of Psychiatry, Faculty of Medicine (FAMED), Federal University at Rio Grande do Sul, Brazil; PTSD Outpatient program (NET-Trauma), Hospital de Clínicas de Porto Alegre, Brazil.
Simone
S
Hauck
Post-Graduate Program in Psychiatry and Behavioral Sciences, Federal University at Rio Grande do Sul, Brazil.
Eduardo S
ES
Vitola
Post-Graduate Program in Psychiatry and Behavioral Sciences, Federal University at Rio Grande do Sul, Brazil; Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Claiton H D
CHD
Bau
Post-Graduate Program in Psychiatry and Behavioral Sciences, Federal University at Rio Grande do Sul, Brazil; Department of Psychiatry, Faculty of Medicine (FAMED), Federal University at Rio Grande do Sul, Brazil; PTSD Outpatient program (NET-Trauma), Hospital de Clínicas de Porto Alegre, Brazil.
Lucia H
LH
Freitas
Post-Graduate Program in Psychiatry and Behavioral Sciences, Federal University at Rio Grande do Sul, Brazil; Department of Psychiatry, Faculty of Medicine (FAMED), Federal University at Rio Grande do Sul, Brazil; PTSD Outpatient program (NET-Trauma), Hospital de Clínicas de Porto Alegre, Brazil. Electronic address: eugenio.grevet@ufrgs.br.
Eugenio H
EH
Grevet
D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D055500:Resilience, Psychological; D057566:Self Report; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000523:psychology*; D011795:Surveys and Questionnaires; D014754:Violence / Q000523:psychology*
C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10
IL-10; IL-6; Low- or middle-income country; PTSD; Resilience; Urban violence