Changes in Red Blood Cell Distribution Width is Associated with Liver Function Parameters and Prognosis in Patients with Chronic HBV Liver Disease.
BACKGROUND
Hepatitis B virus (HBV) infection represents a major threat to global public health, especially in China. The clear pathogenesis of chronic HBV infection (CHB) has not been fully elucidated, but inflammation is widely accepted to play an important role. Emerging evidence suggests that red blood cell distribution (RDW) is a novel potential marker of inflammatory responses. The present study aimed to investigate the clinical relevance of elevated RDW in the patients with chronic HBV liver disease ICP.


METHODS
A total of 731 individuals with chronic HBV liver disease, comprising 92 CHB patients, 606 patients with HBV-related liver cirrhosis (LC), and 33 patients with hepatocellular carcinoma (HCC). Fifty volunteers represented the healthy controls (HC). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (Tbil), albumin (Alb), prothrombin time (PT), and RDW were tested. Correlations between RDW and other clinical parameters were analyzed. A multivariable logistic regression model and the receiver operating characteristic (ROC) curve were used in the analysis of RDW as a predictor of 3-month mortality in the patients with decompensated liver cirrhosis.


RESULTS
Our results showed that RDW was significantly increased in patients with chronic HBV liver disease, except for CHB patients. Moreover, RDW was positively correlated with ALP and PT and negatively correlated with Alb in patients with chronic HBV liver disease. A multivariable logistic regression model showed that RDW was an independent predictor of 3-month mortality in the patients with decompensated liver cirrhosis (odds ratio [OR]: 1.345, 95% confidence interval [CI]: 1.200 - 1.506, p= 0.000). Based on the receiver operating characteristic (ROC) curve, use of RDW as an independent predictor of 3-month mortality was projected to be 17.15%, and yielded a sensitivity and specificity of 92.16% and 66.49%, respectively, with an area under the curve of 0.799 (95% CI: 0.746 - 0.838).


CONCLUSIONS
These data suggest that RDW may be a useful indicator to assess the liver function in patients with chronic HBV liver disease and help to predict mortality in hospitalized patients with decompensated cirrhosis in patients.
Yang
Y
Kai
Guan
G
Zishu
Guan
G
Shihe
Gao
G
Yufeng
Zhou
Z
Qiang
D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000821:virology; D016022:Case-Control Studies; D004909:Erythrocyte Indices; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000821:virology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000821:virology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D011517:Prothrombin Time; D012372:ROC Curve; D013997:Time Factors
D015415:Biomarkers