Low acyl-CoA synthetase 5 expression in colorectal carcinomas is prognostic for early tumour recurrence.
It has been shown that the metabolism of long chain fatty acids is involved in colorectal carcinogenesis. Acyl-CoA synthetases (ACSL) activate free fatty acids by synthesis of acyl-CoA thioesters. ACSL isoform 5 (ACSL5) is involved in enterocytic differentiation and maturation by regulating both pro-apoptotic and anti-proliferative effects. Whilst impaired expression of ACSL5 has been associated with sporadic colorectal carcinogenesis, little is known about ACSL5 as a prognostic factor. Aim of this retrospective study was to characterize the prognostic impact of ACSL5 expression levels in sporadic colorectal adenocarcinomas. A total of 72 patients with a median follow-up of 54 months was included. Using a standardized immunohistochemical approach, colorectal adenocarcinomas with low (n=41; group 1) or high (n=31; group 2) ACSL5 levels were identified. In a one-year follow-up, tumour recurrence was significantly increased in group 1 (p=0.0279). The finding was independent of the TNM- and UICC-stage in the surgical resections. Frequency of lymph node metastasis and mortality was not different between the groups. In a long-time follow-up no differences were found between the ACSL5 groups. The data indicate that ACSL5 could be an independent prognostic factor for early recurrence of sporadic colorectal adenocarcinoma.
Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Franziska
F
Hartmann
Surgical Department, Luisenhospital Aachen, Boxgraben 99, 52064 Aachen, Germany.
Daniela
D
Sparla
Peter L. Reichertz Institute for Medical Informatics, University of Braunschweig-Institute of Technology and Hannover Medical School, Mühlenpfordtstraße 23, 38106 Braunschweig, Germany.
Erik
E
Tute
Department of Medical Statistics RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Miriam
M
Tamm
Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Ursula
U
Schneider
Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Min Kyung
MK
Jeon
Surgical Department, Luisenhospital Aachen, Boxgraben 99, 52064 Aachen, Germany.
Reinhard
R
Kasperk
Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany; Institute of Pathology, Klinikum Braunschweig, Celler Straße 38, 38114 Braunschweig, Germany. Electronic address: ngassler@ukaachen.de.
Nikolaus
N
Gassler
Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany; Department of Pediatrics, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Elke
E
Kaemmerer
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003066:Coenzyme A Ligases / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies
D003066:Coenzyme A Ligases; C115795:acyl CoA synthetase 5
Acyl-CoA synthetase 5; Biomarker; Carcinogenesis; Colorectal cancer; Prognosis