Albuminuria is Suggested as a Potential Health Screening Biomarker for Senior Citizens and General Population with Hypertension or Diabetes in China.
BACKGROUND
To evaluate the possibility of albuminuria as a screening biomarker for seniors or general population with hypertension and diabetes.


METHODS
478 health check-up individuals were enrolled. Albumin to creatinine ratio (ACR) was calculated by testing urinary albumin and creatinine of spot urine sample. Each urine sample was also analyzed by the routine urine test in parallel with ACR. Potential risk factors associated with the presence of albuminuria were analyzed using independent t-test or chi-square test.


RESULTS
The total prevalence of albuminuria was 11.9%, and women had a higher positive rate (14.0%) than men (10.6%). Ageing, fasting plasma glucose, and systolic blood pressure were significantly associated with the presence of albuminuria. Individuals are highly probable to have albuminuria when their routine urine test shows positive of urea glucose, red blood cells or urea protein.


CONCLUSIONS
Albuminuria should be suggested as a potential health screening biomarker in senior citizens and general population with hypertension and diabetes.
Dongmei
D
Gu
Pengcheng
P
Xu
Yuhua
Y
Yuan
Hongwei
H
Fu
D000328:Adult; D000367:Age Factors; D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology* / Q000652:urine; D015415:Biomarkers / Q000652:urine; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000652:urine; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D016482:Urinalysis
D015415:Biomarkers; D003404:Creatinine