D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy.
OBJECTIVE
To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells.


METHODS
TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment.


RESULTS
TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells' viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect.


CONCLUSIONS
TPGS/nGO derivatives are promising materials for breast cancer phototherapy.
CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.
Duarte
D
de Melo-Diogo
CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.
Cleide
C
Pais-Silva
CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.
Elisabete C
EC
Costa
ITQB - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal.
Ricardo O
RO
Louro
CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.
Ilídio J
IJ
Correia
D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006108:Graphite / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D014810:Vitamin E / Q000008:administration & dosage* / Q000737:chemistry
D010087:Oxides; D014810:Vitamin E; D006108:Graphite; C014225:tocophersolan
PEGylated Vitamin E; TPGS; breast cancer; nanographene oxide; phototherapy