Diabetes management and daily functioning burden of non-severe hypoglycemia in Japanese people treated with insulin.
OBJECTIVE
The present study investigated the impact of non-severe hypoglycemic events (NSHE) on patients' diabetes management, daily functioning and well-being.


METHODS
A survey assessing the impact of NSHEs was completed by insulin-treated Japanese people with diabetes, aged ≥20 years with self-reported diabetes, who had experienced at least one NSHE in the past 3 months. Survey questions captured reasons for and the length of the event, and impacts on diabetes management, daily functioning, sleep and well-being.


RESULTS
A total of 3,145 people with type 1 diabetes mellitus and type 2 diabetes mellitus were screened, of which 411 respondents were eligible. Increased glucose monitoring was reported by 57 and 54% of respondents after daytime and night-time NSHE, respectively. The average number of additional glucose monitoring tests was 2.4 and 3.0 for daytime and night-time NSHE. Among all respondents, 19% (daytime) and 16% (night-time) changed their insulin dose after an NSHE. After a daytime NSHE, 25% of respondents reported a negative impact on their daily activities or work. After a night-time NSHE, 34 and 23% of respondents reported a negative impact on sleep and next day emotional state, respectively.


CONCLUSIONS
NSHEs have a negative impact on the diabetes management, daily functioning, sleep and well-being of Japanese patients.
Department of Integrated Science and Engineering for Sustainable Society, Chuo University, Hachioji, Tokyo, Japan.
Yasuo
Y
Ohashi
Novo Nordisk A/S, Søborg, Denmark.
Michael L
ML
Wolden
Novo Nordisk Pharma Ltd, Tokyo, Japan.
Jacob
J
Hyllested-Winge
The Brod Group, Mill Valley, California, USA.
Meryl
M
Brod
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017281:Cost of Illness; D048909:Diabetes Complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000150:complications / Q000188:drug therapy*; D007328:Insulin / Q000627:therapeutic use*; D007564:Japan; D008297:Male; D008875:Middle Aged
D007328:Insulin
Hypoglycemia; Night-time; Non-severe