Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China.
The aim of this study was to investigate the independent and combined effects of fatty acid desaturase 1 (FADS1) gene polymorphism and fish consumption on oral cancer. A hospital-based case-control study was performed including 305 oral cancer patients and 579 cancer-free controls. The genotypes were determined by TaqMan genotyping assay. Non-conditional logistic regression model was used to assess the effects of FADS1 rs174549 polymorphism and fish intake. Subjects carrying A allele of rs174549 significantly reduced the risk of oral cancer (AA VS GG, OR: 0.65, 95% CI: 0.42-0.99; AA VS AG+GG, OR: 0.67, 95% CI: 0.46-0.98). Moreover, the statistically significant reverse associations were especially evident in men, smokers, alcohol drinkers and those age ≤ 60 years. Additionally, fish intake ≥7 times/week showed a 73% reduction in risk for oral cancer compared to those who ate fish less than 2 times/week (OR: 0.27, 95% CI: 0.18-0.42). Furthermore, a significant gene-diet multiplicative interaction was observed between FADS1 rs174549 polymorphism and fish intake for oral cancer (P=0.028). This preliminary study suggests that FADS1 rs174549 polymorphism and fish consumption may be protective factors for oral cancer, with a gene-diet multiplicative interaction. Functional studies with larger samples are required to confirm our findings.
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Fa
F
Chen
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Tao
T
Lin
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Lingjun
L
Yan
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Fengqiong
F
Liu
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Jiangfeng
J
Huang
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Fangping
F
Liu
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Junfeng
J
Wu
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, China.
Yu
Y
Qiu
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, China.
Lisong
L
Lin
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Lin
L
Cai
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China.
Baochang
B
He
D000328:Adult; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D002681:China; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005260:Female; D005399:Fishes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D011110:Polymorphism, Genetic / Q000235:genetics*
D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human
case-control study; fatty acid desaturase 1; fish consumption; oral cancer; polymorphism