Bariatric Surgery Restores Gut-Brain Signaling to Reduce Fat Intake.
Hankir and colleagues (2017) show that gastric bypass surgery in rats enhances the sensitivity of cells in the gut to dietary lipids. In turn, these cells signal to stimulate dopamine neurotransmission in the striatum to inhibit fat consumption. The findings have important implications for the development of non-invasive therapeutics for obesity.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
Stephanie
S
Caligiuri
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Electronic address: paul.kenny@mssm.edu.
Paul J
PJ
Kenny
D000818:Animals; D050110:Bariatric Surgery; D001921:Brain / Q000601:surgery; D004041:Dietary Fats; D015390:Gastric Bypass; D009765:Obesity / Q000601:surgery; D051381:Rats
D004041:Dietary Fats