Distribution and potential significance of intravillous and intrafibrinous particulate microcalcification.
Radiologic studies indicate that placental calcifications seen at 28-32 weeks' gestation are associated with adverse fetal outcome. One type of placental calcification is typically located at the basement membrane of chorionic villi. It has a fine particulate appearance and can only be seen microscopically. We have designated these calcifications as Intravillous and Intrafibrinous Particulate MicroCalcification (IPMC). In this study we examined the distribution and potential significance of IPMC. Placentas from 14 groups of fetal and maternal outcomes are examined histologically for IPMC. These groups were preterm birth, post term birth, intrauterine fetal demise, fetuses with non-reassuring heart rates, intrauterine growth restriction, fetal anomalies, mothers with gestational hypertension, gestational diabetes, placental abruption, pre-eclampsia and placentas of normal spontaneous vaginal births and placentas with chorioamnionitis, chronic villitis and infarcts. We observed fine dust-like particulates deposited in continuous and discrete patches. The particulates were predominantly located in the basement membranes of fibrotic chorionic villi and in perivillous fibrin. Compared to placentas without adverse outcomes, a higher incidence of IPMC was seen in intrauterine fetal demise cases and in cases with infarcts which suggests that hypoxia played a role in the etiology of IPMC.
Department of Pathology, New York University Langone Medical Center, 550 First Avenue, 10016 New York, NY, USA. Electronic address: Jennifer.Zeng@nyumc.org.
Jennifer
J
Zeng
Department of Pathology, New York University Langone Medical Center, 550 First Avenue, 10016 New York, NY, USA.
Alan
A
Marcus
Department of Pathology, New York University Langone Medical Center, 550 First Avenue, 10016 New York, NY, USA.
Tatiana
T
Buhtoiarova
Department of Pathology, New York University Langone Medical Center, 550 First Avenue, 10016 New York, NY, USA.
Khushbakhat
K
Mittal
D002114:Calcinosis / Q000473:pathology*; D002824:Chorionic Villi / Q000473:pathology*; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D047928:Premature Birth / Q000473:pathology
Chorionic villi; Microcalcification; Perivillous fibrin; Placenta