[A rare CD5-positive subgroup of diffuse large B-cell lymphoma - clinical, morphological and immunophenotypic features in Polish patients].
The aim of the study was to assess the incidence of CD5-positive diffuse large B-cell lymphoma (DLBCL) in the Polish population and to describe its morphologic and clinical characteristics. The study included 36 patients with CD5-positive DLBCL, diagnosed and treated in the Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland and the Medical University of Warsaw, Poland in the years 2002-2013. The control group consisted of 28 patients with CD5-negative DLBCL. CD5-positive DLBCL accounted for 6.26% of all DLBCL cases diagnosed in the Maria Skłodowska-Curie Institute and Oncology Centre in the years 2008-2012. The incidence is comparable to other European countries, lower than noted in Japan and higher than in the US. Patients with CD5-positive DLBCL, in comparison to the CD5-negative group, were characterized by: (1) older age (≥ 60 vs. younger) and worse general status (ECOG ≥ 2 vs. < 2), (2) lower frequency of complete remission (CR), (3) higher expression of unfavorable prognostic factors (BCL2, FOXP1, CD44) and MMP-9, and (4) lower expression of favorable prognostic factors (CD30, cyclin D1, cyclin D3) and TIMP-2.
Department of Pathology and Laboratory Diagnostics, Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland. nina.woznialis@gmail.com.
Nina
N
Woźnialis
Department of Pathology and Laboratory Diagnostics, Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland.|Department of Pathology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
Beata
B
Gierej
Department of Lymphoid Malignancies, Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland.
Lidia
L
Popławska
Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Mateusz
M
Ziarkiewicz
Department of Pathology and Laboratory Diagnostics, Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland.
Elżbieta
E
Kulczycka
Department of Pathology and Laboratory Diagnostics, Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland.|Department of Pathology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
Bogna
B
Ziarkiewicz-Wróblewska
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018956:CD5 Antigens / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D015994:Incidence; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology
D018956:CD5 Antigens
 CD5-positive DLBCL;  prognostic factors; NHL