Long noncoding RNA MEG3, a potential novel biomarker to predict the clinical outcome of cancer patients: a meta-analysis.
Numerous studies have demonstrated that the expression level of maternally expressed gene 3 (MEG3) was lost in various cancers. Low expression of MEG3 is associated with an increased risk of metastasis and a poor prognosis in cancer patients. This meta-analysis investigated the association between MEG3 levels and distant metastasis (DM), lymph node metastasis (LNM), overall survival (OS), and recurrence-free survival (RFS) of cancer patients. A total of 536 participants from 9 articles were finally enrolled. The results showed a significant negative association between MEG3 levels and DM (OR = 2.16, 95% CI = 0.99-4.71, P = 0.05, fixed-effect), and it could also predict poor OS (HR = 0.43, 95% CI = 0.15-1.24, P = 0.006, fixed-effect) and RFS (HR = 0.52, 95% CI = 0.29-0.92, P = 0.02, fixed-effect) in cancer patients. In conclusion, this meta-analysis indicated that MEG3 might serve as a potential novel biomarker for indicating the clinical outcomes in human cancers.
Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.|China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China.|Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China.
Xiangrong
X
Cui
Clinical Laboratory, Shanxi Province People's Hospital, Shanxi, 030000, China.
Xuan
X
Jing
Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.|China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China.|Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China.
Chunlan
C
Long
Cardiovascular Department (Internal Medicine), Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Jie
J
Tian
Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.|China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China.|Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China.
Jing
J
Zhu
D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*
D014408:Biomarkers, Tumor; C498907:MEG3 non-coding RNA, human; D062085:RNA, Long Noncoding
MEG3; carcinoma; clinical outcome; lncRNA; meta-analysis