Relationship of recovered hepatitis B infection with appearance of toxic propylthiouracil hepatitis.
Aim To investigate the relationship between recovered hepatitis B infection with appearance of toxic propylthiouracil (PTU) hepatitis and point out the growing importance of the use of drugs in the development of hepatitis. Methods A case of a 45-year-old female patient with suspicion of acute viral hepatitis who had polypragmasy of drugs in the last ten years, due to the polymorphism of symptoms/illnesses (diabetes mellitus, depression, hypertension, hypothyroidism) was presented. Results A female patient had hyperthyroidism after resolved viral hepatitis B with HBsAg seroconversion (HBsAg negative, antiHBs positive). PTU had the greatest potential for hepatotoxicity of all administered drugs. After corticosteroid therapy there was a significant improvement in liver function tests. In the course of the disease there was no change of hepatitis markers and exacerbations of hepatitis B. Conclusion Clinical practice should comprehensively monitor the effects of the intricate and tight connection between drugs, liver and endocrine system in order to better resolve all manifestations, complications and worsening of one or another organic system.
Department of Infectious Diseases, Cantonal Hospital, Zenica, Bosnia and Herzegovina.
Lejla
L
Čalkić
Department of Infectious Diseases, Cantonal Hospital, Zenica, Bosnia and Herzegovina.
Lejla
L
Bajramović-Omeragić
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D015897:Comorbidity; D005260:Female; D006509:Hepatitis B / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D011441:Propylthiouracil / Q000633:toxicity*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D011441:Propylthiouracil
HBsAg seroconversion; drugs; hepatotoxicity; hyperthyroidism