True rise in anaphylaxis incidence: Epidemiologic study based on a national health insurance database.
The incidence trend of anaphylaxis in Asia is not well investigated. The aim of this study is to estimate the entire population-based incidence of anaphylaxis in Korea using a nationwide administrative database.Data over a 7-year period (2008-2014) was obtained from the Korean National Health Insurance (NHI) claims database which covers 97.9% of the entire Korean population. Using diagnosis codes from the International Classification of Diseases-10 for anaphylaxis (T78.0, T78.2, T80.5, and T88.6), we identified the annual number of patients who had visited any hospital with a primary diagnosis of anaphylaxis. Incidence rates were calculated using the population distribution data of all NHI beneficiaries.The incidence of anaphylaxis in Korea was 32.19 episodes per 100,000 person-years in 2014, which nearly doubled from 2008 (16.02 episodes per 100,000 person-years). The incidence of anaphylaxis increased continuously throughout these years regardless of gender and age groups (P for trend < 0.001). Female was significantly less predisposed than male (adjusted odds ratio [OR], 0.69; 95% confident interval [CI], 0.66-0.72; P < 0.001). The incidence was the lowest in 0 to 19 age group and the highest in 40 to 69 age group (adjusted OR, 2.41; 95% CI, 2.29-2.54; P < 0.001).In conclusion, we report the increasing time trend of anaphylaxis incidence rates using nationwide claims database for the first time in Asia.
Department of Internal medicine, SMG-SNU Boramae Medical Center Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul Department of Internal Medicine, Gyeongsang National University Hospital, Jinju Department of Internal medicine, Seoul National University Bundang Hospital, Seongnam Department of Internal medicine, Seoul National University College of Medicine Drug Safety Monitoring Center, Seoul National University Hospital, Seoul, Korea.
Min-Suk
MS
Yang
Ju-Young
JY
Kim
Byung-Keun
BK
Kim
Heung-Woo
HW
Park
Sang-Heon
SH
Cho
Kyung-Up
KU
Min
Hye-Ryun
HR
Kang
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000707:Anaphylaxis / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D017678:Sex Distribution; D055815:Young Adult