A case of T-cell lymphoproliferative disorder associated with hypereosinophilia with excellent response to mycophenolate mofetil.
Hypereosinophilic syndrome (HES) is a group of rare blood disorders characterized by a persistent elevation of blood eosinophil count ⩾1.5×109/L and clinical manifestations attributable to eosinophilia or tissue hypereosinophilia. Lymphocytic variant of HES (HES-L) is a known subtype according to World Health Organization classification. It is well documented in the literature that patients with HES-L are predisposed to develop T-cell lymphoma. We report a case of T-cell lymphoproliferation associated with hypereosinophilia, which has been successfully treated with mycophenolate mofetil, with resolution of skin lesions and normalization of eosinophil count and immunoglobulin E level. We believe this is a clinically relevant case since this is a rare disease with little known knowledge on its best treatment modality.
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: ahanbali@kfshrc.edu.sa.
Amr
A
Hanbali
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Marwan
M
Shaheen
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Feras
F
Alfraih
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Wafa
W
Al-Otaibi
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Riad
R
El Fakih
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Tarek
T
Owaidah
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Syed
S
Ahmed
D000368:Aged; D004804:Eosinophils; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008232:Lymphoproliferative Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D009173:Mycophenolic Acid / Q000008:administration & dosage*; D013601:T-Lymphocytes
D007073:Immunoglobulin E; D009173:Mycophenolic Acid
Hypereosinophilia; Mycophenolate mofetil; T-cell lymphoproliferative disorder