Serum-Derived Hyaluronan-Associated Protein Is a Novel Biomarker for Inflammatory Bowel Diseases.
OBJECTIVE
We evaluated the role of serum-derived hyaluronan-associated protein (SHAP) in inflammatory bowel disease (IBD) pathogenesis and its potential as a novel IBD biomarker.


METHODS
We studied the SHAP expression in a mouse model of colitis and in human intestinal samples of IBD and compared serum concentrations with normal controls.


RESULTS
SHAP was expressed in the connective tissue derived from inflamed regions of the intestine. In mice, serum levels of SHAP-hyaluronic acid (SHAP-HA) were positively correlated with the histological damage of the colon (r = 0.566, p < 0.001). Serum concentration of SHAP-HA complex was significantly higher in patients with active ulcerative colitis than in those in remission, and this value was positively correlated with the erythrocyte sedimentation rate, serum level of tumor necrosis factor (TNF)-α, and endoscopic damage (r = 0.568, p < 0.001; r = 0.521, p < 0.001, and r = 0.641, p < 0.001). In patients with Crohn's disease, the serum SHAP-HA level correlated only with TNF-α (r = 0.630, p = 0.002).


CONCLUSIONS
SHAP is a novel IBD biomarker that is related to disease activity in certain types of colitis, and it may affect disease pathogenesis. Future studies are needed to evaluate the therapeutic potential of this complex.
Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
Yoshiharu
Y
Yamaguchi
Hisatsugu
H
Noda
Noriko
N
Okaniwa
Kazunori
K
Adachi
Tetsuya
T
Shinmura
Shoko
S
Nakagawa
Masahide
M
Ebi
Naotaka
N
Ogasawara
Yasushi
Y
Funaki
Lisheng
L
Zhuo
Koji
K
Kimata
Makoto
M
Sasaki
Kunio
K
Kasugai
D000510:Alpha-Globulins / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D003106:Colon / Q000378:metabolism / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000510:Alpha-Globulins; D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; C011877:inter-alpha-inhibitor; D016264:Dextran Sulfate