A Tale of Division and Polarization in the Mammalian Embryo.
The first cell fate choice in mouse development is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm. In this issue of Developmental Cell, Korotkevic and colleagues (2017) show that the interplay between cell polarization and cell-cell contact drives the segregation of these lineages, providing a framework for self-organization in development.
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address: shankar.srinivas@dpag.ox.ac.uk.
Shankar
S
Srinivas
British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address: tristan.rodriguez@imperial.ac.uk.
Tristan Argeo
TA
Rodriguez
D000818:Animals; D001755:Blastocyst; D002454:Cell Differentiation; D004622:Embryo, Mammalian; D051379:Mice