Periomphalitis with Delayed Umbilical Cord Separation due to Alloimmune Neonatal Neutropenia.
In a preterm infant, small-for-gestational age, neutropenia persisted from the birth, and periomphalitis symptoms appeared at 23 days of age. Upon administration of granulocyte colony-stimulating factor, the neutrophil count increased, and periomphalitis was recovered. At the same time, the umbilical cord separated at 44 days of age. The human neutrophil antigen (HNA) of the infant was 1a/1b, and antineutrophil antibody for HNA-1b was present in both serums of the mother and the infant at birth, indicating a diagnosis of alloimmune neutropenia. This case demonstrated a definite relationship between the number of neutrophils and the separation of umbilical cord.
Tomohiro
T
Sameshima
Sota
S
Iwatani
Sachiyo
S
Fukushima
Mariko
M
Taniguchi-Ikeda
Makoto
M
Hashimoto
Kimiko
K
Yurugi
Kazumoto
K
Iijima
Ichiro
I
Morioka
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001724:Birth Weight; D005260:Female; D005434:Flow Cytometry; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D007519:Isoantigens / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D011247:Pregnancy; D014470:Umbilical Cord / Q000276:immunology* / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic; D007519:Isoantigens; C067704:neutrophil-specific antigen NA1, human