First report on bio-catalytic N-formylation of amines using ethyl formate.
A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.
Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa 403110, India. bhanu.manjunath@syngenta.com.
Rupesh E
RE
Patre
Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa 403110, India. bhanu.manjunath@syngenta.com.
Sanjib
S
Mal
Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa 403110, India. bhanu.manjunath@syngenta.com.
Pankaj R
PR
Nilkanth
Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa 403110, India. bhanu.manjunath@syngenta.com.
Sujit K
SK
Ghorai
Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa 403110, India. bhanu.manjunath@syngenta.com.
Sudhindra H
SH
Deshpande
Syngenta Crop Protection Muenchwilen AG., Schaffhauserstrasse, CH-4332 Stein, CH3RD42, Switzerland.
Myriem
M
El Qacemi
Syngenta Crop Protection Muenchwilen AG., Schaffhauserstrasse, CH-4332 Stein, CH3RD42, Switzerland.
Tomas
T
Smejkal
Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa 403110, India. bhanu.manjunath@syngenta.com.
Sitaram
S
Pal
Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa 403110, India. bhanu.manjunath@syngenta.com.
Bhanu N
http://orcid.org/0000-0001-9834-1724
BN
Manjunath