Silver deposited carboxymethyl chitosan-grafted magnetic nanoparticles as dual action deliverable antimicrobial materials.
Carboxymethyl chitosan (CMCS) was known to have a much better antimicrobial activity than chitosan due to the increased cationic -NH3+groups resulted from the intra- and intermolecular interactions between the carboxyl and amino groups. CMCS was grafted onto the surface of silica coated magnetic nanoparticles (MNPs) to obtain magnetically retrievable and deliverable antimicrobial nanoparticles (MNPs@CMCS). The presence of carboxylate groups in CMCS not only enhanced antimicrobial activity but also enabled Ag ions chelating ability to induce the in situ formation of Ag nanoparticles (AgNPs). The deposition of AgNPs on the surface of MNPs@CMCS could significantly increase its antimicrobial activity against planktonic cells due to the dual action of CMCS and AgNPs. Due to its high magnetism, the as-prepared MNPs@CMCS-Ag could be efficiently delivered into an existing biofilm under the guidance of an applied magnetic field. Without direct contact, the Ag ions and/or radical oxygen species (ROS) released from the deposited Ag nanoparticles could effectively kill the bacteria embedded in the extracellular polymeric substances (EPS) matrix of biofilm.
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
Duc-Thang
DT
Vo
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
Sabrina
S
Sabrina
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan. Electronic address: cklee@mail.ntust.edu.tw.
Cheng-Kang
CK
Lee
D000890:Anti-Infective Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D008856:Microscopy, Fluorescence; D012834:Silver / Q000494:pharmacology*; D013052:Spectrometry, X-Ray Emission; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
D000890:Anti-Infective Agents; D058185:Magnetite Nanoparticles; C514968:carboxymethyl-chitosan; D012834:Silver; D048271:Chitosan
Antimicrobial activity; Carboxymethyl chitosan; Magnetic nanoparticles; Silver nanoparticles