Phenolics and neolignans isolated from the fruits of Juglans mandshurica Maxim. and their effects on lipolysis in adipocytes.
Juglans mandshurica Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of J. mandshurica. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts. Among them, 2-(4-formyl-2-methoxyphenoxy)-propan-1,3-diol and 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol exhibited the most potent lipolytic activities.
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea.
SeonJu
S
Park
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea.
Nanyoung
N
Kim
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea.
Guijae
G
Yoo
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea.
Sang-Nam
SN
Kim
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea.
Hyun-Jung
HJ
Kwon
Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Sungnam 13844, South Korea.
Kiwon
K
Jung
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, South Korea.
Dong-Chan
DC
Oh
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea.
Yun-Hee
YH
Lee
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea. Electronic address: kimsh11@yonsei.ac.kr.
Seung Hyun
SH
Kim
D017667:Adipocytes / Q000187:drug effects*; D000818:Animals; D005638:Fruit / Q000737:chemistry; D031324:Juglans / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D008066:Lipolysis / Q000187:drug effects*; D051379:Mice; D008809:Mice, Inbred C3H; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry
D017705:Lignans; D010636:Phenols; D010936:Plant Extracts
(-)-Evofolin B (Pubchem CID: 46229015); Anti-obesity; Juglandaceae; Juglans mandshurica Maxim.; Lipolysis; Neolignans; O(2) consumption