Pregnancy in a patient with congenital analbuminaemia.
Congenital analbuminaemia is a rare autosomal recessive disorder that is characterised by a severe reduction or total absence of serum albumin. This condition has implications for therapeutics as a large proportion of commonly used drugs are plasma protein bound where albumin is the primary component of plasma protein. This is the first case report of pregnancy in a patient with congenital analbuminaemia in the medical literature. In the absence of drug dosage guidelines for patients with congenital analbuminaemia, a list of drugs which may be required for this patient during pregnancy, delivery and/or emergency situations were compiled by a multidisciplinary team. Our patient suffered from polyhydramnios during her pregnancy which was successfully managed with albumin transfusions and had a normal vaginal delivery with no complications in the intrapartum or postpartum period. The management and unique challenges of pregnancy in a patient with congenital analbuminaemia are discussed.
Department of Obstetrics and Gynaecology, Westmead Hospital, Sydney, New South Wales, Australia.
Hillary
H
Hu
Department of Maternal and Foetal Medicine, Obstetrics and Gynaecology, Westmead Hospital, Sydney, New South Wales, Australia.
Roshini
R
Nayyar
Department of Clinical Immunology and Immunopathology, Westmead Hospital, Sydney, New South Wales, Australia.
Lucinda Jean
LJ
Berglund
Department of Medicines Information, Pharmacy, Westmead Hospital, Sydney, New South Wales, Australia.
Elizabeth Anne
EA
Anderson
D000013:Congenital Abnormalities / Q000175:diagnosis*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D009154:Mutation; D006831:Polyhydramnios / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D012709:Serum Albumin / Q000008:administration & dosage / Q000172:deficiency* / Q000235:genetics; D055815:Young Adult
D012709:Serum Albumin