NMR Spin-Lock Induced Crossing (SLIC) dispersion and long-lived spin states of gaseous propane at low magnetic field (0.05T).
When parahydrogen reacts with propylene in low magnetic fields (e.g., 0.05T), the reaction product propane develops an overpopulation of pseudo-singlet nuclear spin states. We studied how the Spin-Lock Induced Crossing (SLIC) technique can be used to convert these pseudo-singlet spin states of hyperpolarized gaseous propane into observable magnetization and to detect1H NMR signal directly at 0.05T. The theoretical simulation and experimental study of the NMR signal dependence on B1power (SLIC amplitude) exhibits a well-resolved dispersion, which is induced by the spin-spin couplings in the eight-proton spin system of propane. We also measured the exponential decay time constants (TLLSSor TS) of these pseudo-singlet long-lived spin states (LLSS) by varying the time between hyperpolarized propane production and SLIC detection. We have found that, on average, TSis approximately 3 times longer than the corresponding T1value under the same conditions in the range of pressures studied (up to 7.6atm). Moreover, TSmay exceed 13s at pressures above 7atm in the gas phase. These results are in agreement with the previous reports, and they corroborate a great potential of long-lived hyperpolarized propane as an inhalable gaseous contrast agent for lung imaging and as a molecular tracer to study porous media using low-field NMR and MRI.
Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: danila.barskiy@vanderbilt.edu.
Danila A
DA
Barskiy
International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova St., Novosibirsk, Russia.
Oleg G
OG
Salnikov
International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova St., Novosibirsk, Russia.
Alexey S
AS
Romanov
Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
Matthew A
MA
Feldman
Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
Aaron M
AM
Coffey
International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova St., Novosibirsk, Russia.
Kirill V
KV
Kovtunov
International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova St., Novosibirsk, Russia.
Igor V
IV
Koptyug
Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center (VICC), Vanderbilt University, Nashville, TN 37232, USA; Russian Academy of Sciences, Moscow, Russia. Electronic address: eduard.chekmenev@vanderbilt.edu.
Eduard Y
EY
Chekmenev
D003198:Computer Simulation; D003287:Contrast Media; D004574:Electromagnetic Fields; D005740:Gases / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011312:Pressure; D011407:Propane / Q000737:chemistry*; D011522:Protons; D012815:Signal Processing, Computer-Assisted; D014979:Xenon Isotopes
D003287:Contrast Media; D005740:Gases; D011522:Protons; D014979:Xenon Isotopes; D011407:Propane
Hyperpolarization; Long-lived spin states; Low field; MRI; NMR; Parahydrogen; Propane