Comparison of two-risk assessment algorithms for preeclampsia in first trimester with consecutive intake of low-dose aspirin in the high-risk group - an observational study.
We analyzed outcome of women screened for preeclampsia with two different multifactorial risk algorithms (Predictor®Software by PerkinElmer, PerkinElmer, Waltham, MA; PERK-group: n = 214 and Viewpoint®by GE Healthcare, Dornstadt, Germany; VIEW-group: n = 209) in first trimester. Women at high risk for developing preeclampsia were advised to take low-dose acetylsalicylic acid (LDA). Screening positive rates for early onset preeclampsia differed significantly between the two groups (7.9% versus 26.3%; p = 0.000). According the clinical use of screening test criteria, LDA was prescribed in 63 (29.4%) women in the PE-group and 55 (26.3%) in the VP-group (p = 0.516). There were no differences in onset of preeclampsia [4 (1.9%) versus 6 (2.9%); p = 0.540]. No early or severe preeclampsia occurred in the whole population.
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Ioana-Claudia
IC
Lakovschek
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Bence
B
Csapo
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Vassiliki
V
Kolovetsiou-Kreiner
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Karoline
K
Mayer-Pickel
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Philipp
P
Reif
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Christina
C
Stern
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Daniela
D
Ulrich
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Uwe
U
Lang
b Division of Endocrinology and Metabolism, Department of Internal Medicine , Endocrinology Lab Platform, Medical University of Graz , Graz , Austria.
Barbara
B
Obermayer-Pietsch
a Division of Obstetrics, Department of Obstetrics and Gynaecology , Medical University of Graz , Graz , Austria.
Mila
M
Cervar-Zivkovic
D000465:Algorithms; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000517:prevention & control; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
Preeclampsia; aspirin; first-trimester screening; low-dose acetylsalicylic acid