Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10.
Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.
School of Medicine, University of Queensland, Brisbane, QLD, Australia; School of Biomedical Science, Curtin University, Perth, W.A., Australia; Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, QLD, Australia.
Samuel
S
Halstrom
School of Medicine, University of Queensland, Brisbane, QLD, Australia; Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, QLD, Australia.
Rachel
R
Thomson
Harry Perkins Institute of Medical Research, Perth, W.A., Australia.
Hayley
H
Goullee
Institute for Respiratory Health, University of Western Australia, Perth, W.A., Australia.
Svetlana
S
Baltic
School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, W.A., Australia.
Richard
R
Allcock
Harry Perkins Institute of Medical Research, Perth, W.A., Australia.
Suzanna E L
SE
Temple
School of Biomedical Science, Curtin University, Perth, W.A., Australia; School of Physiology, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: patricia.price@curtin.edu.au.
Patricia
P
Price
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000235:genetics*; D009170:Nontuberculous Mycobacteria / Q000502:physiology*; D011014:Pneumonia / Q000235:genetics* / Q000382:microbiology; D020641:Polymorphism, Single Nucleotide; D044465:White People
D016753:Interleukin-10
Genetic polymorphism; IL10; Nontuberculous mycobacteria; Pulmonary disease