Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation.
Stroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single flexible passive demodulated circuit printed by flexible printed circuit (FPC) technique and output pulse voltage stimulus by inductively coupling an external circuit. The wireless implantable board was implanted in cats' unilateral epidural space for electrical stimulation of the primary visual cortex (V1) while the evoked responses were recorded on the contralateral V1 using a needle electrode. The wireless implantable board output stable monophasic voltage stimuli. The amplitude of the monophasic voltage output could be adjusted by controlling the voltage of the transmitter circuit within a range of 5-20 V. In acute experiment, cortico-cortical evoked potential (CCEP) response was recorded on the contralateral V1. The amplitude of N2 in CCEP was modulated by adjusting the stimulation intensity of the wireless interface. These results demonstrated that a wireless interface based on a microcoil array can offer a valuable tool for researchers to explore electrical stimulation in research and the dura mater-electrode interface can effectively transmit electrical stimulation.
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. wangxing@cqu.edu.cn.
Xing
X
Wang
School of Medicine and Health Sciences, George Washington University, Washington, DC 20037, USA. sharjeel@gwu.edu.
Sharjeel A
SA
Chaudhry
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. w.s.hou@cqu.edu.cn.
Wensheng
W
Hou
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA. xjia@som.umaryland.edu.|Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. xjia@som.umaryland.edu.|Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. xjia@som.umaryland.edu.|Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. xjia@som.umaryland.edu.|Department of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. xjia@som.umaryland.edu.
Xiaofeng
X
Jia
D000818:Animals; D002415:Cats; D004558:Electric Stimulation / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D004824:Epidural Space; D005071:Evoked Potentials; D019736:Prostheses and Implants; D014793:Visual Cortex; D059015:Wireless Technology
epidural cortical stimulation; inductive coupling; micro coil; nerve-electrode interface; rehabilitation; stroke