Incidence, survival, pathology, and genetics of adult Latino Americans with glioblastoma.
Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data from 2001 to 2011 draws from 28% of the U.S.



Latinos have a lower incidence of GBM and present slightly younger than non-Latino Whites. Cubans present at an older age than other Latino sub-populations. Latinos have a higher incidence of giant cell glioblastoma than non-Latino Whites while the incidence of gliosarcoma is similar. Despite lower rates of radiation therapy and greater rates of sub-total resection than non-Latino Whites, Latinos have better 1 and 5 year survival rates. SEER does not record chemotherapy data. Survivals of Latino sub-populations are similar with each other. Age, extent of resection, and the use of radiation therapy are associated with improved survival but none of these variables are sufficient in a multivariate analysis to explain the improved survival of Latinos relative to non-Latino Whites. As molecular data is not available in SEER records, we studied the MGMT and IDH status of 571 patients from a UCLA database. MGMT methylation and IDH1 mutation rates are not statistically significantly different between non-Latino Whites and Latinos. For UCLA patients with available information, chemotherapy and radiation rates are similar for non-Latino White and Latino patients, but the latter have lower rates of gross total resection and present at a younger age.
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Maryam
M
Shabihkhani
Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, USA.
Donatello
D
Telesca
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Masoud
M
Movassaghi
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Yalda B
YB
Naeini
Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Kourosh M
KM
Naeini
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Seyed Amin
SA
Hojat
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Diviya
D
Gupta
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Gregory M
GM
Lucey
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Michael
M
Ontiveros
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Michael W
MW
Wang
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Lauren S
LS
Hanna
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Desiree E
DE
Sanchez
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Sergey
S
Mareninov
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.
Negar
N
Khanlou
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA.|Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Harry V
HV
Vinters
Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.|Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA.
Marvin
M
Bergsneider
Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Phioanh Leia
PL
Nghiemphu
Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.|Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA.
Albert
A
Lai
Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.|Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA.
Linda M
LM
Liau
Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.|Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA.
Timothy F
TF
Cloughesy
Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA. wyong@mednet.ucla.edu.|Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA. wyong@mednet.ucla.edu.
William H
WH
Yong
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D015254:DNA Modification Methylases / Q000235:genetics / Q000378:metabolism; D045643:DNA Repair Enzymes / Q000235:genetics / Q000378:metabolism; D066264:Datasets as Topic / Q000706:statistics & numerical data; D005260:Female; D005909:Glioblastoma / Q000453:epidemiology / Q000235:genetics / Q000401:mortality / Q000473:pathology; D006630:Hispanic or Latino; D006801:Humans; D015994:Incidence; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D016019:Survival Analysis; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D014481:United States / Q000453:epidemiology
D025521:Tumor Suppressor Proteins; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes
Ethnicity; Giant cell glioblastoma; Glioblastoma; Hispanic; Latino; Race