WNK Kinase Signaling in Ion Homeostasis and Human Disease.
WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl-cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.
Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Masoud
M
Shekarabi
Departments of Neurosurgery, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06477, USA; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
Jinwei
J
Zhang
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA 02115, USA.
Arjun R
AR
Khanna
Division of Nephrology & Hypertension, Department of Medicine, Oregon Health & Science University, Portland, Oregon 97239, USA; VA Portland Health Care System, Portland, OR 97239, USA.
David H
DH
Ellison
Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Eric
E
Delpire
Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06477, USA. Electronic address: kristopher.kahle@yale.edu.
Kristopher T
KT
Kahle
D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D048429:Cell Size; D004194:Disease; D006706:Homeostasis; D006801:Humans; D007477:Ions; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
D007477:Ions; D017346:Protein Serine-Threonine Kinases
GABA; KCC2; KCC3; NCC; NKCC1; WNK1; WNK3; WNK4; chloride; homeostasis; kidney