Association of hypoproteinemia in preeclampsia with maternal and perinatal outcomes: A retrospective analysis of high-risk women.
BACKGROUND
The aim of this study was to evaluate maternal and perinatal outcomes in preeclampsia (PE), according to the value of albumin.


METHODS
Preeclamptic women were retrospectively divided into mild hypoproteinemia (MHP,n= 220) and severe hypoproteinemia (SHP,n= 79) PE according to the value of albumin. The maternal and perinatal outcomes were evaluated in both groups.


RESULTS
Two hundred and ninety-nine single pregnancies complicated by PE were included in this study. Gestational age at delivery was earlier in SHP than MHP (P< 0.01). Severe hypertension, abnormal liver function, abnormal renal function, ascites, and abruption occurred more frequently in SHP than in MHP (P< 0.01, 0.03, <0.01, 0.01, and 0.04, respectively). Women in SHP had a higher rate of cesarean section than those in MHP (P= 0.04). Fetal growth restriction infants were more frequent in SHP than in MHP (P< 0.01). The occupancy rate of the Neonatal Intensive Care Unit was higher in SHP than in MHP (P< 0.01).


CONCLUSIONS
SHP PE is associated with a higher risk of adverse pregnancy outcome than MHP PE, deserving closer surveillance during pregnancy.
Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, China; Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China.
Hongbo
H
Chen
Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China.
Feng
F
Tao
Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China.
Xiangdong
X
Fang
Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, China.
Xietong
X
Wang
Hypoproteinemia; perinatal; preeclampsia; pregnancy outcome