Tobacco Exposure and Conditional Weight-for-Length Gain by 2 Years of Age.
To prospectively examine dose-response and timing effects of prenatal (PTE) and postnatal tobacco exposure on obesity risk assessed by conditional weight-for-length gain (CWFLG), by 2 years of age. CWFLG over the first 2 years of life was examined for 117 PTE and 57 nonexposed children. Repeated assessments of PTE were conducted beginning in the first trimester of pregnancy, using multiple methods. PTE or postnatal exposure status was not predictive of CWFLG. However, there was a dose-response association and an association with fetal exposure ascertained by infant meconium positive for nicotine and metabolites. PTE is related to restricted growth at birth, yet associated with accelerated CWFLG by 2 years of age, a measure that controls for birthweight differences. Results highlight the importance of examining dose-response and timing of exposure associations, along with the importance of obesity risk-reduction interventions within the first 2 years of life among PTE children.
Department of Child and Youth Studies, Brock University.|Research Institute on Addictions, State University of New York at Buffalo.
Danielle S
DS
Molnar
Department of Psychology, University of South Florida.
Diana
D
Rancourt
Department of Psychology, University of South Florida.
Robert
R
Schlauch
Division of Behavioral Medicine, Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo.
Xiaozhong
X
Wen
Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health.
Marilyn A
MA
Huestis
Research Institute on Addictions, State University of New York at Buffalo.
Rina D
RD
Eiden
D001827:Body Height; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D063766:Pediatric Obesity / Q000175:diagnosis / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000175:diagnosis / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D015430:Weight Gain
D014028:Tobacco Smoke Pollution
growth; obesity; prenatal tobacco exposure; second-hand smoke exposure; toddler