Bile acids and their receptors.
Primary bile acids are synthetized from cholesterol within the liver and then transformed by the bacteria in the intestine to secondary bile acids. In addition to their involvement in digestion and fat solubilization, bile acids also act as signaling molecules. Several receptors are sensors of bile acids. Among these receptors, this review focuses on the nuclear receptor FXRα and the G-protein-coupled receptor TGR5. This review briefly presents the potential links between bile acids and cancers that are discussed in more details in the other articles of this special issue of Molecular Aspects of Medicine focused on "Bile acids, roles in integrative physiology and pathophysiology".
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
Emmanuelle
E
Martinot
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
Lauriane
L
Sèdes
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
Marine
M
Baptissart
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
Jean-Marc
JM
Lobaccaro
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
Françoise
F
Caira
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
Claude
C
Beaudoin
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France. Electronic address: david.volle@inserm.fr.
David H
DH
Volle
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D001711:Biotransformation; D002784:Cholesterol / Q000378:metabolism; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011110:Polymorphism, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D000099150:Receptor, Farnesoid X-Activated
D001647:Bile Acids and Salts; D002784:Cholesterol; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled; D000099150:Receptor, Farnesoid X-Activated; C473772:GPBAR1 protein, human
Bile acid; Homeostasis; Intestine; Liver; Receptors