Plasma pro-atrial natriuretic peptide to estimate fluid balance during open and robot-assisted esophagectomy: a prospective observational study.
It remains debated how much fluid should be administered during surgery. The atrial natriuretic peptide precursor proANP is released by atrial distension and deviations in plasma proANP are reported associated with perioperative fluid balance. We hypothesized that plasma proANP would decrease when the central blood volume is compromised during the abdominal part of robot-assisted hybrid (RE) esophagectomy and that a positive fluid balance would be required to maintain plasma proANP.



Patients undergoing RE (n = 25) or open (OE; n = 25) esophagectomy for gastroesophageal cancer were included consecutively in this prospective observational study. Plasma proANP was determined repetitively during esophagectomy to allow for distinction between the abdominal and thoracic part of the procedure. The RE group was 15° head up tilted during the abdominal procedure.



The blood loss was 250 (150-375) (RE) and 600 ml (390-855) (OE) (p = 0.01), but the two groups of patients were provided with a similar positive fluid balance: 1705 (1390-1983) vs. 1528 ml (1316-1834) (p = 0.4). However, plasma proANP decreased by 21% (p < 0.01) during the abdominal part of RE carried out during moderate head-up tilt, but only by 11% (p = 0.01) during OE where the patients were supine. Plasma proANP and fluid balance were correlated in the RE-group (r = 0.5 (0.073-0.840), p = 0.02) and tended to correlate in the OE group (r = 0.4 (-0.045-0.833), p = 0.08).



The results support that plasma proANP decreases when the central blood volume is compromised and suggest that an about 2200 ml surplus administration of crystalloid is required to maintain plasma proANP during esophagectomy.



Clinicaltrials.gov ( NCT02077673 ). Registered retrospectively February 12th2014.
Department of Surgical Gastroenterology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen-Ø, Denmark. rune.broni.strandby.01@regionh.dk.
Rune Broni
RB
Strandby
Department of Surgical Gastroenterology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen-Ø, Denmark.
Rikard
R
Ambrus
Department of Anesthesiology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, Copenhagen-Ø, DK-2100, Denmark.
Niels H
NH
Secher
Department of Clinical Biochemistry, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, Copenhagen-Ø, DK-2100, Denmark.
Jens Peter
JP
Goetze
Department of Surgical Gastroenterology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen-Ø, Denmark.
Michael Patrick
MP
Achiam
Department of Surgical Gastroenterology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen-Ø, Denmark.
Lars Bo
LB
Svendsen
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D016629:Esophagectomy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012371:Robotics; D014882:Water-Electrolyte Balance
D009320:Atrial Natriuretic Factor
Abdominal surgery; Central blood volume; Fluid balance; Plasma-atrial natriuretic peptide