Effectiveness of Antibiotic Use Management in Tianjin (2011-2013): A Quasi-Experimental Study.
BACKGROUND In this study we investigated changes in the status of antibiotic use in Tianjin since the implementation of the Antibiotic Stewardship Program (ASP) (2011-2013), as well as existing problems, strategies, and outcomes to promote rational clinical antibiotic use. MATERIAL AND METHODS A quasi-experimental study was performed to investigate situations of antibiotic use in secondary and tertiary general hospitals in Tianjin from April 2011 to 2013. Five major indicators were analyzed: percentage of antibiotic use in inpatient cases (%), antibacterial use density (AUD), proportion of prophylactic antibiotic application for type I surgical incision, compliance rate of medication administration 0.5-2.0 h before such procedures, and antibiotic prophylaxis for ≤24 h in patients receiving these surgeries. RESULTS There was a decrease in the percentage of antibiotic use across general hospitals (60.38% to 46.88%), in AUD (51.60% to 35.37%), and in the proportion of prophylactic antibiotic applications for type I incisions (86.67% to 25.08%). For patients undergoing these procedures, there was an increased compliance rate of medication administration of 0.5-2.0 h prior to surgery (86.38% to 100%), and of antibiotic prophylactic use for ≤24 h (40.30% to 96.37%). CONCLUSIONS Implementation of the ASP campaign has reduced irrational antibiotic use, promoted rational antibiotic use, and delayed antibiotic resistance.
School of Public Health, Tianjin Medical University, Tianjin, China (mainland).
Hai-Hong
HH
Zhang
School of Public Health, Tianjin Medical University, Tianjin, China (mainland).
Yue
Y
Du
Department of Public Health, Tianjin Municipal Commission of Health and Family Planning, Tianjin, China (mainland).
Wei
W
Liu
Department of Infectious Diseases, The Second Hospital of Tianjin Medical University, Tianjin, China (mainland).
Shi-Duo
SD
Song
Department of Infectious Diseases, The Second Hospital of Tianjin Medical University, Tianjin, China (mainland).
Wen
W
Zhao
School of Public Health, Tianjin Medical University, Tianjin, China (mainland).
Guo-Wei
GW
Huang
School of Public Health, Tianjin Medical University, Tianjin, China (mainland).
He-Sheng
HS
Wang
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000706:statistics & numerical data*; D002681:China; D004352:Drug Resistance, Microbial; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000188:drug therapy
D000900:Anti-Bacterial Agents