Mass Spectrometry Applications for Toxicology.
Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both. To date, MS applications have permeated all fields of toxicology which include; environmental, clinical, and forensic toxicology. While many different analytical applications are used in these fields, MS and its hyphenated applications such as; gas chromatography MS (GC-MS), liquid chromatography MS (LC-MS), inductively coupled plasma ionization MS (ICP-MS), tandem mass spectrometry (MS/MS and MSn) have emerged as powerful tools used in toxicology laboratories. This review will focus on these hyphenated MS technologies and their applications for toxicology.
Department of Laboratory Medicine, Mayo Clinic , Rochester, MN, USA.
Michael M
MM
Mbughuni
Department of Laboratory Medicine, Mayo Clinic , Rochester, MN, USA.
Paul J
PJ
Jannetto
Department of Laboratory Medicine, Mayo Clinic , Rochester, MN, USA.
Loralie J
LJ
Langman
Environmental toxicology; clinical toxicology; forensic toxicology; mass spectrometry technologies