[Lactic acidosis due to metformin accumulation complicating acute gastroenteritis].
Lactic acidosis is the most severe adverse effect associated with metformin therapy of type 2 diabetes mellitus. The risk increases in patients with impaired renal function, most commonly due to diabetic nephropathy, and may be augmented when concurrent medication with a negative impact on renal function is used. The authors present a series of three patients who were admitted to a department of infectious diseases for acute gastroenteritis and within a few hours developed shock syndrome caused by severe lactic acidosis due to accumulation of metformin.
Department of infectious diseases, 3rd faculty of medicine Charles University, Na Bulovce Hospital, Prague, Czech Republic, e-mail: olga.dzupova@lf3.cuni.cz.
Olga
O
DŽupová
Jana
J
Kulichová
D000140:Acidosis, Lactic / Q000139:chemically induced*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005260:Female; D005759:Gastroenteritis / Q000150:complications*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D007004:Hypoglycemic Agents; D008687:Metformin