Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross-Coupling.
An environmentally friendly electrocatalytic protocol has been developed for dehydrogenative C-H/S-H cross-coupling. This method enabled C-S bond formation under catalyst- and oxidant-free conditions. Under undivided electrolysis conditions, various aryl/heteroaryl thiols and electron-rich arenes afforded the C-S bond-formation products in 24-99 % yield. A preliminary mechanistic study indicated that the generation of aryl radical cation intermediates is key to the success of this transformation.
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R. China.
Pan
P
Wang
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R. China.
Shan
S
Tang
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R. China.
Pengfei
P
Huang
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R. China.|State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P.R. China.
Aiwen
0000-0001-8417-3061
A
Lei
C−H functionalization; C−S bond formation; dehydrogenation; electrochemistry; radical cations