[Safety of statins].
The discovery of statins, was a landmark in primary and secondary prevention of cardiovascular disease, where cholesterol plays a central pathophysiologic role. Currently there are 7 statins, which according to recent meta-analytic studies did not reveal significant differences in effectiveness measured by results of cardiovascular morbidity and mortality. This means that the selection of a particular statin, could be very important aspects of safety and cost. The two adverse reactions greater interest currently on statins are rhabdomyolysis and risk of type 2 diabetes mellitus; the first is an adverse reaction appeared almost from the birth of these drugs and caused the withdrawal of cerivastatin, while the second has been recently reported. Significant differences have been reported between different statins, in relation to the two mentioned adverse reactions.
Instituto de Investigación de la Facultad de Medicina de la Universidad de San Martin de Porres. Sección Farmacología de la Universidad Nacional Mayor de San Marcos. Hospital Almenara, Departamento de Medicina Interna. Lima, Perú.
Teodore J
TJ
Oscanoa Espinoza
Director del Instituto de Investigación de la Facultad de Medicina de la Universidad de San Martin de Porres. Lima, Perú.
Napoleon
N
Paredes-Pérez
Facultad de Medicina de la Universidad de San Martin de Porres. Lima, Perú.
Frank
F
Lizaraso-Soto
D002318:Cardiovascular Diseases / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors