The Cut-off Values of Triglycerides and Glucose Index for Metabolic Syndrome in American and Korean Adolescents.
The aim of this study was to establish ethnic- and gender-specific cut-off values of triglycerides and glucose index (TyG index) for clinical usefulness in a representative sample of Mexican American, Non-Hispanic White, Non-Hispanic Black, and Korean adolescents. The data were collected from datasets of the National Health and Nutrition Examination Survey between 1999 and 2012, and the Korean National Health and Nutrition Examination Survey between 2005 and 2013. Receiver operating characteristic curve analysis was used to find valid cut-off values of the TyG index for metabolic syndrome. The total number of eligible participants was 3,164 in the US and 4,873 in Korea. The optimal cut-off value with the Cook et al. definition revealed 8.55 in Mexican American, 8.55 in Non-Hispanic White, 8.35 in Non-Hispanic Black, and 8.45 in Korean, respectively. The cut-off value with the de Ferranti et al. definition was 8.45, 8.45, 8.15, and 8.35, and the cut-off value with the International Diabetes Federation definition was 8.65, 8.65, 8.15, and 8.55, respectively. These findings may be clinically useful for evaluating insulin resistance for determining metabolic abnormalities in adolescents.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Shinje
http://orcid.org/0000-0003-3298-3630
S
Moon
Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Korea.
Joon Sung
http://orcid.org/0000-0003-4740-3061
JS
Park
Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Korea. ahnyh1129@gmail.com.
Youhern
http://orcid.org/0000-0002-4357-1730
Y
Ahn
D000293:Adolescent; D001741:Black or African American; D019540:Area Under Curve; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis*; D017058:Mexican Americans; D009749:Nutrition Surveys; D012372:ROC Curve; D012016:Reference Values; D056910:Republic of Korea; D014280:Triglycerides / Q000097:blood* / Q000592:standards; D014481:United States; D044465:White People
D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides
Adolescent; Cardiovascular Disease; Child; Glucose; Insulin; Insulin Resistance; Metabolic Syndrome; Nutrition Surveys; Obesity; Triglycerides