Behavioral Changes Following Uptake of HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in a Clinical Setting.
We describe changes in sexual behaviors among men who have sex with men (MSM) following initiation of pre-exposure prophylaxis (PrEP) in a clinic-based sample of MSM initiating PrEP in Providence, Rhode Island. Data were collected at baseline, 3, and 6 months following PrEP initiation including total number of anal sex partners and condom use. A longitudinal mixed effects model assessed changes in number of partners and condom use over time, adjusting for age, race, and education. There was no statistically significant difference in total number of partners over time. There was a significant increase in number of condomless anal sex partners at the 6-month visit compared to baseline (mean change +1.31 partners, 95% confidence interval 0.09-2.53, P = 0.035). As condomless anal sex may increase following PrEP uptake, adherence counseling and efforts to retain patients in PrEP care, especially during periods of non-condom use, are important as PrEP is more widely implemented.
Francis I. Proctor Foundation, University of California, San Francisco, CA, USA.
Catherine E
CE
Oldenburg
Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA.
Amy S
AS
Nunn
Division of Infectious Diseases, Brown University, Providence, RI, USA.
Madeline
M
Montgomery
Division of Infectious Diseases, Brown University, Providence, RI, USA.
Alexi
A
Almonte
Division of Infectious Diseases, University of Mississippi, Jackson, MS, USA.
Leandro
L
Mena
Division of Infectious Diseases, Washington University, St Louis, MO, USA.
Rupa R
RR
Patel
Department of Medicine, Beth Israel Deaconess Medical CenterHarvard Medical School, Boston, MA, USA.|The Fenway Institute, Fenway Community Health, Boston, MA, USA.
Kenneth H
KH
Mayer
Division of Infectious Diseases, Brown University, Providence, RI, USA. pchan@lifespan.org.|Division of Infectious Diseases, The Miriam Hospital, Providence, RI, USA. pchan@lifespan.org.
Philip A
PA
Chan
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D015658:HIV Infections / Q000517:prevention & control*; D018451:Homosexuality, Male / Q000523:psychology* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care; D065129:Pre-Exposure Prophylaxis; D012237:Rhode Island; D021841:Safe Sex / Q000706:statistics & numerical data*; D012725:Sexual Behavior / Q000706:statistics & numerical data; D012747:Sexual Partners; D055815:Young Adult
D019380:Anti-HIV Agents
Behavioral compensation; HIV; Implementation; Men who have sex with men; Pre-exposure prophylaxis