Pandemic and Avian Influenza A Viruses in Humans: Epidemiology, Virology, Clinical Characteristics, and Treatment Strategy.
The intermittent outbreak of pandemic influenza and emergence of novel avian influenza A virus is worldwide threat. Although most patients present with mild symptoms, some deteriorate to severe pneumonia and even death. Great progress in the understanding of the mechanism of disease pathogenesis and a series of vaccines has been promoted worldwide; however, incidence, morbidity, and mortality remains high. To step up vigilance and improve pandemic preparedness, this article elucidates the virology, epidemiology, pathogenesis, clinical characteristics, and treatment of human infections by influenza A viruses, with an emphasis on the influenza A(H1N1)pdm09, H5N1, and H7N9 subtypes.
Department of Respiratory Medicine, Capital Medical University, NO. 10 You-an -men-wai Xi-tou-tiao, Fengtai District, Beijing 10069, China.
Hui
H
Li
Department of Respiratory Medicine, Capital Medical University, NO. 10 You-an -men-wai Xi-tou-tiao, Fengtai District, Beijing 10069, China; Lab of Clinical Microbiology and Infectious Diseases, Centre of respiratory and Critical Care Medicine, China-Japan Friendship Hospital, NO. 2 Ying-hua Dong-jie, Chao-yang District, Beijing 100029, China. Electronic address: caobin_ben@163.com.
Bin
B
Cao
D004196:Disease Outbreaks; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000453:epidemiology / Q000628:therapy / Q000821:virology
D007252:Influenza Vaccines
Avian influenza A viruses; Clinical characteristics; Epidemiology; Pandemic influenza virus; Treatment; Virology