An Overview of Multimodal Neuroimaging Using Nanoprobes.
Nanomaterials have gained tremendous significance as contrast agents for both anatomical and functional preclinical bio-imaging. Contrary to conventional medical practices, molecular imaging plays an important role in exploring the affected cells, thus providing precision medical solutions. It has been observed that incorporating nanoprobes improves the overall efficacy of the diagnosis and treatment processes. These nano-agents and tracers are therefore often incorporated into preclinical therapeutic and diagnostic applications. Multimodal imaging approaches are well equipped with nanoprobes to explore neurological disorders, as they can display more than one type of characteristic in molecular imaging. Multimodal imaging systems are explored by researchers as they can provide both anatomical and functional details of tumors and affected tissues. In this review, we present the state-of-the-art research concerning multimodal imaging systems and nanoprobes for neuroimaging applications.
School of Electrical & Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. sriram005@e.ntu.edu.sg.
Sriram
S
Sridhar
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore. sachin.mishra@ntu.edu.sg.
Sachin
S
Mishra
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskölds väg 20, Uppsala Se-751 85, Sweden. miklos.gulyas@igp.uu.se.
Miklós
M
Gulyás
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore. ppadmanabhan@ntu.edu.sg.
Parasuraman
P
Padmanabhan
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore. balazs.gulyas@ntu.edu.sg.
Balázs
B
Gulyás
D000818:Animals; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging / Q000379:methods; D049329:Nanostructures; D009369:Neoplasms / Q000000981:diagnostic imaging*; D059906:Neuroimaging / Q000379:methods; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D012106:Research; D000072098:Single Photon Emission Computed Tomography Computed Tomography
D003287:Contrast Media; D019275:Radiopharmaceuticals
multimodal imaging; nanoprobes; neuroimaging; tumor