Advances in positron emission tomography for the imaging of rheumatoid arthritis.
Imaging techniques, such as US, are well recognized as important tools to aid early diagnosis and assess response to treatment in RA. PET offers a means of imaging the inflammatory processes of RA at a cellular level and thus may be a highly sensitive method of assessing synovitis. In this review we discuss the advantages of PET as an imaging modality for RA and summarize the existing clinical studies of PET in RA. We also highlight potentially important preclinical studies of PET in arthritis and discuss current limitations of PET as well as ongoing developments in PET technology likely to be of benefit for arthritis imaging.
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford.
Nehal
N
Narayan
Division of Brain Sciences, Imperial College London.|Imanova Centre for Academic Imaging Sciences, London, UK.
David R
DR
Owen
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford.
Peter C
PC
Taylor
D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D002794:Choline; D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D006801:Humans; D007457:Iodine Radioisotopes; D007546:Isoquinolines; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D018079:Receptors, GABA; D000069283:Rituximab; D012969:Sodium Fluoride; D013585:Synovitis / Q000000981:diagnostic imaging*
D002250:Carbon Radioisotopes; D005710:Gallium Radioisotopes; D007457:Iodine Radioisotopes; D007546:Isoquinolines; D019275:Radiopharmaceuticals; D018079:Receptors, GABA; C499229:TSPO protein, human; D019788:Fluorodeoxyglucose F18; D000069283:Rituximab; D012969:Sodium Fluoride; D002794:Choline; C037850:PK 11195
CT scanning; diagnostic imaging; radiology; radionuclide imaging; rheumatoid arthritis; synovium