Thin chitosan films containing super-paramagnetic nanoparticles with contrasting capability in magnetic resonance imaging.
Magnetic nanoparticles have found application as MRI contrasting agents. Herein, chitosan thin films containing super-paramagnetic iron oxide nanoparticles (SPIONs) are evaluated in magnetic resonance imaging (MRI). To determine their contrasting capability, super-paramagnetic nanoparticles coated with citrate (SPIONs-cit) were synthesized. Then, chitosan thin films with different concentrations of SPIONs-cit were prepared and their MRI data (i.e., r2and r2*) was evaluated in an aqueous medium. The synthesized SPIONs-cit and chitosan/SPIONs-cit films were characterized by FTIR, EDX, XRD as well as VSM with the morphology evaluated by SEM and AFM. The nanoparticle sizes and distribution confirmed well-defined nanoparticles and thin films formation along with high contrasting capability in MRI. Images revealed well-dispersed uniform nanoparticles, averaging 10 nm in size. SPIONs-cit's hydrodynamic size averaged 23 nm in diameter. The crystallinity obeyed a chitosan and SPIONs pattern. The in vitro cellular assay of thin films with a novel route was performed within Hek293 cell lines showing that thin films can be biocompatible.
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. farjadian_f@sums.ac.ir.
Fatemeh
F
Farjadian
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sahar
S
Moradi
Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH, 44325, USA. majid.hosseini01@utrgv.edu.|Manufacturing and Industrial Engineering Department, The University of Texas Rio Grande Valley (UTRGV), Edinburg, TX, 78539, USA. majid.hosseini01@utrgv.edu.
Majid
M
Hosseini
D001672:Biocompatible Materials / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D005290:Ferric Compounds / Q000737:chemistry; D018857:Food Packaging; D057809:HEK293 Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D048271:Chitosan