Ruthenium-NHC-Diamine Catalyzed Enantioselective Hydrogenation of Isocoumarins.
A novel and practical chiral ruthenium-NHC-diamine system is disclosed for the enantioselective hydrogenation of isocoumarins, which provides a new concept to apply (chiral) NHC ligands in asymmetric catalysis. A variety of optically active 3-substituted 3,4-dihydroisocoumarins were obtained in excellent enantioselectivities (up to 99% ee). Moreover, this methodology was utilized in the synthesis of O-methylmellein, mellein, and ochratoxin A.
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstraße 40, 48149 Münster, Germany.
Wei
W
Li
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstraße 40, 48149 Münster, Germany.
Mario P
MP
Wiesenfeldt
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstraße 40, 48149 Münster, Germany.
Frank
0000-0002-0648-956X
F
Glorius
D000147:Acids, Heterocyclic / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D006865:Hydrogenation; D049934:Isocoumarins / Q000737:chemistry*; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D000147:Acids, Heterocyclic; D001688:Biological Products; D003959:Diamines; D049934:Isocoumarins; D012428:Ruthenium