Role of Aquaporin 1 Signalling in Cancer Development and Progression.
Cancer is a major health burden worldwide. Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targets to abrogate angiogenesis and tumour progression. Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport. Recently, over-expression of AQP1 has been associated with many types of cancer as a distinctive clinical prognostic factor. This has prompted researchers to evaluate the link between AQP1 and cancer biological functions. Available literature implicates the role of AQP1 in tumour cell migration, invasion and angiogenesis. This article reviews the current understanding of AQP1-facilitated tumour development and progression with a focus on regulatory mechanisms and downstream signalling pathways.
Molecular Oncology, Basil Hetzel Institute, The Queen Elizabeth Hospital & Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia. Yoko.Tomita@adelaide.edu.au.
Yoko
Y
Tomita
Molecular Oncology, Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia. hilary.dorward07@gmail.com.
Hilary
H
Dorward
Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia. Andrea.Yool@adelaide.edu.au.
Andrea J
AJ
Yool
Molecular Oncology, Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia. Eric.Smith@adelaide.edu.au.
Eric
E
Smith
Medical Oncology, The Queen Elizabeth Hospital & School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia. Amanda.Townsend@sa.gov.au.
Amanda R
AR
Townsend
Medical Oncology, The Queen Elizabeth Hospital & School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia. Timothy.Price@sa.gov.au.
Timothy J
TJ
Price
Molecular Oncology, Basil Hetzel Institute, The Queen Elizabeth Hospital & Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia. Jenny.Hardingham@sa.gov.au.
Jennifer E
JE
Hardingham
D000818:Animals; D051398:Aquaporin 1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers; D002352:Carrier Proteins; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006019:Glycolysis; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
D015415:Biomarkers; D002352:Carrier Proteins; D051398:Aquaporin 1
aquaporin 1; carcinogenesis; tumour angiogenesis; tumour cell migration