Visible Light Copper Photoredox-Catalyzed Aerobic Oxidative Coupling of Phenols and Terminal Alkynes: Regioselective Synthesis of Functionalized Ketones via C≡C Triple Bond Cleavage.
Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. This method allows regioselective synthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene via C≡C triple bond cleavage. 47 examples were presented. From a synthetic perspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical drugs, such as pitofenone and fenofibrate.
Department of Chemistry, National Tsing Hua University , Hsinchu, Taiwan, R. O. C.
Arunachalam
A
Sagadevan
Department of Chemistry, National Tsing Hua University , Hsinchu, Taiwan, R. O. C.
Vaibhav Pramod
VP
Charpe
Department of Chemistry, National Tsing Hua University , Hsinchu, Taiwan, R. O. C.
Ayyakkannu
A
Ragupathi
Department of Chemistry, National Tsing Hua University , Hsinchu, Taiwan, R. O. C.
Kuo Chu
0000-0003-1814-9869
KC
Hwang