IgA Nephropathy.
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenesis of IgAN. Furthermore, establishment of multicenter networks has contributed to rigorous design and execution of clinical trials that have provided important insights regarding immunotherapy in IgAN. In this article, we review emerging developments in clinical and translational IgAN research and describe how these novel findings will influence future strategies to improve the outcome of patients with IgAN.
Department of Medicine, University of Toronto and Division of Nephrology, University Health Network, Toronto, Ontario, Canada.
Jennifer C
JC
Rodrigues
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California; and.
Mark
M
Haas
Department of Medicine, University of Toronto and Division of Nephrology, University Health Network, Toronto, Ontario, Canada.|Gabor Zellerman Chair in Nephrology Research, University of Toronto, Toronto, Ontario, Canada.
Heather N
HN
Reich
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000072700:Conservative Treatment; D004359:Drug Therapy, Combination; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000627:therapeutic use; D010641:Phenotype; D011507:Proteinuria / Q000209:etiology; D051436:Renal Insufficiency, Chronic / Q000209:etiology; D000069283:Rituximab / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D007155:Immunologic Factors; D000069283:Rituximab; D009173:Mycophenolic Acid
IGA; IgA nephropathy; chronic; corticosteroids; crescents; glomerulonephritis; humans; immunosuppression; immunotherapy; kidney; pathology; renal insufficiency; review; translational medical research