Intraoperative irradiation: precision medicine for quality cancer control promotion.
Intraoperative irradiation was implemented 4 decades ago, pioneering the efforts to improve precision in local cancer therapy by combining real-time surgical exploration/resection with high single dose radiotherapy (Gunderson et al., Intraoperative irradiation: techniques and results, 2011). Clinical and technical developments have led to very precise radiation dose deposit. The ability to deliver a very precise dose of radiation is an essential element of contemporary multidisciplinary individualized oncology.This issue of Radiation Oncology contains a collection of expert review articles and updates with relevant data regarding intraoperative radiotherapy. Technology, physics, biology of single dose and clinical results in a variety of cancer sites and histologies are described and analyzed. The state of the art for advanced cancer care through medical innovation opens a significant opportunity for individualize cancer management across a broad spectrum of clinical practice. The advantage for tailoring diagnostic and treatment decisions in an individualized fashion will translate into precise medical treatment.
Department of Radiation Oncology, Department of Oncology, Hospital general Universitario Gregorio Marañon, Complutense University of Madrid, Madrid, Spain. felipe.calvo@salud.madrid.org.|Instituto de Investigación Sanitaria Gregorio Marañon, Grupo Oncologia Interdisciplinar y Biotecnológica. Proyecto PI15/02121, Madrid, Spain. felipe.calvo@salud.madrid.org.|Instituto de Salud Carlos III. Ministerio de Economía y Competitividad. Gobierno de España, Madrid, Spain. felipe.calvo@salud.madrid.org.
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D006801:Humans; D007432:Intraoperative Period; D009369:Neoplasms / Q000532:radiotherapy*; D057285:Precision Medicine / Q000379:methods*; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage
High single dose radiotherapy; Intraoperative irradiation; Precision medicine; Real-time surgical exploration