Association of TNF Receptor 2 and CRP with GFR Decline in the General Nondiabetic Population.
OBJECTIVE
Higher levels of inflammatory markers have been associated with renal outcomes in diabetic populations. We investigated whether soluble TNF receptor 2 (TNFR2) and high-sensitivity C-reactive protein (hsCRP) were associated with the age-related GFR decline in a nondiabetic population using measured GFR (mGFR).


METHODS
A representative sample of 1590 middle-aged people from the general population without prevalent kidney disease, diabetes, or cardiovascular disease were enrolled in the Renal Iohexol-Clearance Survey in Tromsø 6 (RENIS-T6) between 2007 and 2009. After a median of 5.6 years, 1296 persons were included in the Renal Iohexol-Clearance Survey Follow-Up Study. GFR was measured using iohexol clearance at baseline and follow-up.


RESULTS
The mean decline of mGFR during the period was -0.84 ml/min per 1.73 m2per year. There were 133 participants with rapid mGFR decline, defined as an annual mGFR loss >3.0 ml/min per 1.73 m2, and 26 participants with incident CKD, defined as mGFR<60 ml/min per 1.73 m2at follow-up. In multivariable adjusted mixed models, 1 mg/L higher levels of hsCRP were associated with an accelerated decline in mGFR of -0.03 ml/min per 1.73 m2per year (95% confidence interval [95% CI], -0.05 to -0.01), and 1 SD higher TNFR2 was associated with a slower decline in mGFR (0.09 ml/min per 1.73 m2per year; 95% CI, 0.01 to 0.18). In logistic regression models adjusted for sex, age, weight, and height, 1 mg/L higher levels of hsCRP were associated with higher risk of rapid mGFR decline (odds ratio, 1.03; 95% CI, 1.01 to 1.06) and incident CKD (odds ratio, 1.04; 95% CI, 1.00 to 1.08).


CONCLUSIONS
Higher baseline levels of hsCRP but not TNFR2 were associated with accelerated age-related mGFR decline and incident CKD in a general nondiabetic population.
Metabolic and Renal Research Group and.|Section of Nephrology, University Hospital of North Norway, Tromsø, Norway; and.
Jørgen
J
Schei
Metabolic and Renal Research Group and.
Vidar Tor Nyborg
VTN
Stefansson
Metabolic and Renal Research Group and.|Section of Nephrology, University Hospital of North Norway, Tromsø, Norway; and.
Bjørn Odvar
BO
Eriksen
Metabolic and Renal Research Group and.|Department of Nephrology, Oslo University Hospital, Oslo, Norway.
Trond Geir
TG
Jenssen
Metabolic and Renal Research Group and.|Section of Nephrology, University Hospital of North Norway, Tromsø, Norway; and.
Marit Dahl
MD
Solbu
Department of Community Medicine, University in Tromsø (UiT) The Arctic University of Norway, Tromsø, Norway.
Tom
T
Wilsgaard
Metabolic and Renal Research Group and.|Section of Nephrology, University Hospital of North Norway, Tromsø, Norway; and.
Toralf
T
Melsom
D000368:Aged; D000375:Aging / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D003287:Contrast Media; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007472:Iohexol; D008297:Male; D008875:Middle Aged; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000503:physiopathology; D013548:Sweden / Q000453:epidemiology
D003287:Contrast Media; D047889:Receptors, Tumor Necrosis Factor, Type II; D007472:Iohexol; D002097:C-Reactive Protein
C-Reactive Protein; Cardiovascular Diseases; Follow-Up Studies; GFR decline; Humans; Inflammation; Iohexol, kidney; Kidney Function Tests; Logistic Models; Measured GFR; Middle Aged; Odds Ratio; Receptors, Tumor Necrosis Factor, Type II; Renal Insufficiency, Chronic; Surveys and Questionnaires; TNFRSF1B protein, human; aging; chronic kidney disease; cytokines; diabetes mellitus; glomerular filtration rate; soluble TNF receptors