Poly(lactic-co-glycolic) acid drug delivery systems through transdermal pathway: an overview.
In past few decades, scientists have made tremendous advancement in the field of drug delivery systems (DDS), through transdermal pathway, as the skin represents a ready and large surface area for delivering drugs. Efforts are in progress to design efficient transdermal DDS that support sustained drug release at the targeted area for longer duration in the recommended therapeutic window without producing side-effects. Poly(lactic-co-glycolic acid) (PLGA) is one of the most promising Food and Drug Administration approved synthetic polymers in designing versatile drug delivery carriers for different drug administration routes, including transdermal drug delivery. The present review provides a brief introduction over the transdermal drug delivery and PLGA as a material in context to its role in designing drug delivery vehicles. Attempts are made to compile literatures over PLGA-based drug delivery vehicles, including microneedles, nanoparticles, and nanofibers and their role in transdermal drug delivery of different therapeutic agents. Different nanostructure evaluation techniques with their working principles are briefly explained.
Center for Textile Science and Technology, University of Minho, Guimarães, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil.|Department of Mechanical Engineering, Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore, 117581, Singapore.
Lucas
L
Naves
Anti-Infectives Research Group, Singapore Eye Research Institute, Singapore, 169856, Singapore.
Chetna
C
Dhand
Center for Textile Science and Technology, University of Minho, Guimarães, Portugal.
Luis
L
Almeida
Anti-Infectives Research Group, Singapore Eye Research Institute, Singapore, 169856, Singapore.
Lakshminarayanan
L
Rajamani
Department of Mechanical Engineering, Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore, 117581, Singapore.|Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, 510632, China.
Seeram
S
Ramakrishna
Center for Textile Science and Technology, University of Minho, Guimarães, Portugal. gmbs@det.uminho.pt.
Graça
G
Soares
Drug delivery system; Electrospinning technique; Microneedles; PLGA; Transdermal drug delivery