Hydrogen sulfide in stroke: Protective or deleterious?
Hydrogen sulfide is believed to be a signalling molecule in the central nervous system. It is known to increase rapidly following an ischemic insult in experimental stroke. Is it protective or deleterious? This review surveys the relevant information available in the literature. It appears that there is no definitive answer to this question at present. Current evidence seems to suggest that the presence of H2S in the ischemic brain may either be deleterious or protective depending on its concentration, deleterious when high and protective when low. Therefore, it can be inferred that either an enhancement or a reduction of its concentration may be of potential use in future stroke therapy.
Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore; Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, USA.
Su Jing
SJ
Chan
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: peter_wong@nuhs.edu.sg.
Peter T-H
PT
Wong
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism* / Q000627:therapeutic use / Q000633:toxicity; D020521:Stroke / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control*
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D006862:Hydrogen Sulfide
Hydrogen sulphide; Neuroprotection; Stroke; Toxic effect