Obtaining the palygorskite:chitosan composite for modified release of 5-aminosalicylic acid.
This study's aim was to obtain composites from palygorskite (PLG) and chitosan (CS) in order to modify 5-aminosalicylic (5-ASA) release. Initially, the PLG:CS composite was obtained using glutaraldehyde (GLA) as a reticular agent. Then, PLG, CS and PLG:CS were characterized by means of analytical techniques such as CHN elemental analysis, surface area analysis, XRD, FTIR, DSC and TG, SEM, adsorption tests and release profiles. Based on analytical data, the formation of the PLG:CS composite which showed the presence about 19% of CS, decrease in specific surface area, morphological analysis modified, visible change of crystallinity, of FTIR and thermal analysis. In relation to the drug-composite interaction, PLG:CS exhibited a significant increase in adsorption with 5-ASA at 58.24% in relation to PLG and CS which were at 16.29% and 23.96% respectively. The release profiles show that the PLG:CS composite changed the 5-ASA release speed in analyzed simulated fluids (intestinal and stomach) unlike other systems. Thus, the PLG:CS composite with proven synergy of the PLG and CS inherent properties showing 5-ASA effective modified release. Hence, this composite has potential benefits for the vectorization of drugs.
Department of Pharmacy, Federal University of Pernambuco, Av. Professor Moraes Rego 1235, 50670-901 Recife, Pernambuco, Brazil. Electronic address: acsgv@hotmail.com.
Ana Cristina Sousa Gramoza Vilarinho
ACSGV
Santana
Department of Pharmacy, Federal University of Pernambuco, Av. Professor Moraes Rego 1235, 50670-901 Recife, Pernambuco, Brazil.
José Lamartine Soares
JLS
Sobrinho
Department of Chemistry, Federal University of Piaui, Ministro Petrônio Portela Campus, 64049-550 Teresina, Piaui, Brazil.
Edson Cavalcanti da
ECD
Silva Filho
Department of Pharmacy, Federal University of Piaui, Ministro Petrônio Portela Campus, 64049-550 Teresina, Piaui, Brazil.
Livio Cesar Cunha
LCC
Nunes
D000327:Adsorption; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D065546:Drug Liberation; D007700:Kinetics; D017616:Magnesium Compounds / Q000737:chemistry*; D019804:Mesalamine / Q000032:analysis*; D008962:Models, Theoretical; D017655:Silicon Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D017616:Magnesium Compounds; D017655:Silicon Compounds; D019804:Mesalamine; D048271:Chitosan; C026325:attapulgite
Composite; Drug release; Mesalazine