The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice.
BACKGROUND
Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear.


METHODS
C57BL/6j male mice were irradiated with UVB (1.0 kJ/m2/day) for 3 days. Five days after the final session of UVB irradiation, the dorsal skin, ear epidermis, and blood samples were analyzed to investigate the inflammatory factors, melanogenesis factors and related hormones.


RESULTS
After the oral administration of CA (100 mg/day) or CGA (100 mg/day) for 8 days, only CA was found to inhibit dermatitis and pigmentation. The pathway by which CA inhibits dermatitis is related to the mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK)1/2/cAMP response element binding protein (CREB) pathway. Otherwise, the pathway by which CA inhibits pigmentation is related to the activation of the β-endorphin-μ-opioid receptor and suppresses the cAMP-microphthalmia-associated transcription factor (MITF) pathway.


CONCLUSIONS
It is suggested that the oral administration of CA prevented dermatitis and pigmentation after UVB irradiation in mice.
Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.
Yurika
Y
Yamate
Keiichi
K
Hiramoto
Eisuke F
EF
Sato
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D002109:Caffeic Acids / Q000494:pharmacology*; D002726:Chlorogenic Acid / Q000494:pharmacology; D003069:Coffee; D003872:Dermatitis / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008810:Mice, Inbred C57BL; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D012880:Skin Pigmentation / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D000521:alpha-MSH / Q000097:blood; D001615:beta-Endorphin / Q000097:blood
D002109:Caffeic Acids; D003069:Coffee; D002726:Chlorogenic Acid; D000521:alpha-MSH; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D020928:Mitogen-Activated Protein Kinases; C040048:caffeic acid