Synthesis of the Pentacyclic Core of Citreamicin η.
The citreamicins comprise a novel class of polycyclic xanthone natural products that have not yet yielded to total synthesis. A concise 11-step synthesis of the pentacyclic core of citreamicin η is now reported that features the use of a general approach for the synthesis of 1,4-dioxygenated xanthones. The synthesis also showcases improved techniques for effecting regioselective bromination of certain substituted phenols and coupling of acetylides with hindered ketones.
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Shawn
S
Blumberg
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Stephen F
0000-0002-4639-0695
SF
Martin