Effects of curcumin onHelicobacter pyloriinfection.
BACKGROUND
Curcumin is a well-established natural molecule with significant biological and pharmaceutical effects. Its effects onHelicobacter pylori(H. pylori) infection have been repeatedly confirmed both in animal and human models. This study directly compared five different samples to evaluate if the effects are general or if they differ among samples.


METHODS
Using a mouse model, we studied the effects of curcumin on lipid peroxide (LPO) level, myeloperoxidase (MPO) and urease activity, number of colonized bacteria, levels of anti-H. pyloriantibodies, biofilm formation, IFN-γ, IL-4, gastrin and somatostatin levels in serum, and minimum inhibitory concentration. In addition, we evaluated the effects on biofilm production and antibacterial antibody response.


RESULTS
In all tests, one sample (Sabinsa) was consistently the most active.


CONCLUSIONS
All curcumin samples showed some anti-H. pylorieffects, but only some of the tested samples had significant activity.
Department of Pathology, University of Louisville, Louisville, KY, USA.
Vaclav
V
Vetvicka
Department of Pathology, University of Louisville, Louisville, KY, USA.
Jana
J
Vetvickova
Department of Pathology, University of Louisville, Louisville, KY, USA.
Rafael
R
Fernandez-Botran
Biofilm; Helicobacter pylori (H. pylori); curcumin