Copper deficiency-related bone marrow changes secondary to long-term total parenteral nutrition.
Total parenteral nutrition can be complicated by the marrow sea-blue histiocytes as well as copper deficiency-related bone marrow changes. Cytoplasmic vacuoles in the erythroid and myeloid precursors raise the possibility of copper deficiency anemia. If the diagnosis is delayed, the clinical course can be complicated by neurologic deficits.
The University of Texas M.D. Anderson Cancer Center Houston Texas USA.
Thein Hlaing
0000-0002-5201-731X
TH
Oo
The University of Texas M.D. Anderson Cancer Center Houston Texas USA.
Shimin
S
Hu
Copper deficiency; cytoplasmic vacuoles; sea‐blue histiocytes; total parenteral nutrition