Aerobic training prior to myocardial infarction increases cardiac GLUT4 and partially preserves heart function in spontaneously hypertensive rats.
We assessed cardiac function (echocardiographic) and glucose transporter 4 (GLUT4) expression (Western blot) in response to 10 weeks of aerobic training (treadmill) prior to acute myocardial infarction (AMI) by ligation of the left coronary artery in spontaneously hypertensive rats. Animals were allocated to sedentary+sham, sedentary+AMI, training+sham, and training+AMI. Aerobic training prior to AMI partially preserves heart function. AMI and/or aerobic training increased GLUT4 expression. However, those animals trained prior to AMI showed a greater increase in GLUT4 in cardiomyocytes.
a Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, RS, 90620-001, Brazil.
Maximiliano Isoppo
MI
Schaun
a Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, RS, 90620-001, Brazil.
Rafael Aguiar
RA
Marschner
a Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, RS, 90620-001, Brazil.
Thiago Rodrigues
TR
Peres
a Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, RS, 90620-001, Brazil.
Melissa Medeiros
MM
Markoski
a Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, RS, 90620-001, Brazil.|b Faculdade Sogipa de Educação Física, Porto Alegre, Rio Grande do Sul, 90550-003, Brazil.
Alexandre Machado
AM
Lehnen
D000208:Acute Disease; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D051275:Glucose Transporter Type 4 / Q000097:blood / Q000235:genetics*; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics*; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats; D011918:Rats, Inbred SHR
D001786:Blood Glucose; D051275:Glucose Transporter Type 4; C495694:Slc2a4 protein, rat
GLUT4; SHR; acute myocardial infarction; entraînement physique; exercise training; infarctus aigu du myocarde