Anticoagulant-related nephropathy: a case report and review of the literature of an increasingly recognized entity.
Treatment with oral anticoagulants has been associated with worsening kidney function in patients with chronic kidney disease (CKD) as well as among patients without underlying CKD. Thus, anticoagulant-related nephropathy (ARN) is an increasingly recognized entity nowadays, mainly associated with warfarin anticoagulation. Recent evidence indicates that patients treated with the direct anticoagulants may also be at risk of ARN. However, the true incidence of anticoagulant-related nephropathy is difficult to determine. The typical histological lesion involves renal tubular occlusion by red blood cells (RBCs), tubular red blood cell casts on light microscopy and dysmorphic RBCs in the glomerulus on electron microscopy. In the absence of active glomerulonephritis or other inflammatory changes that could account for glomerular hemorrhage, the above findings confirm the diagnosis. Dabigatran etexilate was the first direct oral anticoagulant approved for stroke prevention in patients with non-valvular atrial fibrillation. In this article, we describe a rare case of dabigatran etexilate-induced nephropathy in a patient with preexisting IgA nephropathy and review the recent literature regarding this increasingly recognized entity.
Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece. rigaska@gmail.com.
Rigas G
RG
Kalaitzidis
Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Anila
A
Duni
1st Department of Pathology Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgios
G
Liapis
Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Olga
O
Balafa
Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Sofia
S
Xiromeriti
Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Paulos Karolos
PK
Rapsomanikis
Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.|Department of Internal Medicine, Medical School, University of Ioannina, 451 10, Ioannina, Greece.
Moses S
MS
Elisaf
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D000069604:Dabigatran / Q000009:adverse effects*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced / Q000503:physiopathology; D012307:Risk Factors
D000925:Anticoagulants; D000069604:Dabigatran
Anticoagulant-related nephropathy; Dabigatran etexilate; IgA nephropathy; Oral anticoagulants; Warfarin