Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis.
OBJECTIVE
This meta-analysis investigates the prognostic effect of SET binding protein 1 (SETBP1) mutations in patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), or chronic neutrophilic leukemia (CNL).


METHODS
Eligible studies from Pubmed, Embase, and Web of Science were searched from database inception through April 2016. Hazard ratios (HRs) and 95% confidence interval (CI) of overall survival (OS) were pooled to calculate the prognostic significance of SETBP1 mutation in patients.


RESULTS
A total of 12 studies with 2321 patients were included in this meta-analysis; 4 studies for MDS, 5 studies for CMML, and 3 studies for CNL. Pooled results suggested that MDS and CMML patients with SETBP1 mutations had a significantly poorer prognosis when compared with patients with wild-type SETBP1 (MDS: HR = 1.808, 95% CI (1.218-2.685), P = 0.001; CMML: HR = 2.223, 95% CI (1.493-3.308), P<0.001). SETBP1 mutations in CNL patients however, showed no significant effect on the overall survival (HR = 1.773, 95% CI (0.877-3.582), P = 0.111). The Begg's and Egger's tests did not show significant publication bias in any groups.


CONCLUSIONS
Current evidence shows that SETBP1 mutation is associated with a poor prognosis in patients with MDS and CMML, but not in patients with CNL.
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Li-Hong
LH
Shou
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Dan
D
Cao
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Xiao-Hui
XH
Dong
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Qiu
Q
Fang
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Ying
Y
Wu
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Yan
Y
Zhang
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Ju-Ping
JP
Fei
Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang, China.
Bao-Lian
BL
Xu
D002352:Carrier Proteins / Q000235:genetics*; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics* / Q000473:pathology*; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics* / Q000473:pathology*; D009154:Mutation / Q000235:genetics; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology*; D009687:Nuclear Proteins / Q000235:genetics*; D011379:Prognosis
D002352:Carrier Proteins; D009687:Nuclear Proteins; C425066:SETBP1 protein, human