Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.
Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. To explore the relationship between single nucleotide polymorphisms (SNPs) in heat shock protein 70 (HSP70) genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility to NIHL in Han Chinese workers exposed to noise, a case-control association study was carried out with 286 hearing loss cases and 286 matched with gender, age, type of work, and exposure time, drawn from a population of 3790 noise-exposed workers. Four SNPs were selected and genotyped. Subsequently, the effects of the alleles and genotypes of the three HSP70 genes (HSPA1A, HSPA1B and HSPA1L) on NIHL were analyzed by using a conditional logistic regression. A generalized multiple dimensionality reduction (GMDR) was applied to further detect an interaction between the four SNPs. Compared with the combined genotypes CC/TC, carriers of the TT genotype of rs2763979 appeared to show greater susceptibility to NIHL (P = 0.042, adjusted OR = 1.731, 95% CI 1.021-2.935). A significant interaction between rs2763979 and CNE was found (P = 0.029), and a significant association was found between TT of s2763979 and NIHL (P = 0.024, adjusted OR = 5.694, 95%CI 1.256-25.817) in the 96 dB (A)≤CNE<101 dB (A) group. The results suggest that the rs2763979 locus of the HSP70 genes may be associated with susceptibility to NIHL in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.
Henan Provincial Institute for Occupational Health, Zhengzhou, People's Republic of China.
Yanhong
Y
Li
Henan Provincial Institute for Occupational Health, Zhengzhou, People's Republic of China.
Shanfa
S
Yu
Henan Provincial Institute for Occupational Health, Zhengzhou, People's Republic of China.
Guizhen
G
Gu
Wugang Institute for Occupational Health, Wugang, People's Republic of China.
Guoshun
G
Chen
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Yuxin
Y
Zheng
Henan Provincial Institute for Occupational Health, Zhengzhou, People's Republic of China.
Jie
J
Jiao
Henan Provincial Institute for Occupational Health, Zhengzhou, People's Republic of China.
Wenhui
W
Zhou
Henan Provincial Institute for Occupational Health, Zhengzhou, People's Republic of China.
Hui
H
Wu
Henan Provincial Institute for Occupational Health, Zhengzhou, People's Republic of China.
Zengrui
Z
Zhang
Wugang Institute for Occupational Health, Wugang, People's Republic of China.
Huanling
H
Zhang
Department of Occupational Health and Environmental Health, School of Public Health, Peking University, Beijing, People's Republic of China.
Lihua
L
He
Department of Occupational Health and Environmental Health, School of Public Health, Peking University, Beijing, People's Republic of China.
Qiuyue
Q
Yang
Department of Occupational Health and Environmental Health, School of Public Health, Peking University, Beijing, People's Republic of China.
Xiangrong
X
Xu
D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational / Q000009:adverse effects; D020641:Polymorphism, Single Nucleotide
D018840:HSP70 Heat-Shock Proteins; C490786:HSPA1A protein, human; C525621:HSPA1B protein, human; C543454:HSPA1L protein, human