ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.
The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task.



We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations.



ARResT/Interrogate is implemented primarily in R, and is freely available at http://bat.infspire.org/arrest/interrogate/



nikos.darzentas@gmail.com



Supplementary data are available at Bioinformatics online.
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Vojtech
V
Bystry
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Tomas
T
Reigl
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.|RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Adam
A
Krejci
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Martin
M
Demko
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Barbora
B
Hanakova
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.|Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo/Fondazione MBBM, Monza, Italy.
Andrea
A
Grioni
Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Henrik
H
Knecht
Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Max
M
Schlitt
Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Peter
P
Dreger
Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Leopold
L
Sellner
Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Dietrich
D
Herrmann
Department of Hematology, Hopital Pitié-Salpêtrière and Pierre et Marie Curie University, Paris, France.
Marine
M
Pingeon
Department of Hematology, Hopital Pitié-Salpêtrière and Pierre et Marie Curie University, Paris, France.
Myriam
M
Boudjoghra
Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Jos
J
Rijntjes
Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Christiane
C
Pott
Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Anton W
AW
Langerak
Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Patricia J T A
PJTA
Groenen
Department of Hematology, Hopital Pitié-Salpêtrière and Pierre et Marie Curie University, Paris, France.
Frederic
F
Davi
Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Monika
M
Brüggemann
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Nikos
N
Darzentas
D014644:Genetic Variation; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D007125:Immunogenetics / Q000379:methods*; D007136:Immunoglobulins / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism*; D012984:Software
D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell