Pulmonary Delivery of Magnetically Targeted Nano-in-Microparticles.
This chapter details the intratracheal delivery of dry powder microparticles termed nano-in-microparticles (NIMs) for the purpose of in vivo targeted pulmonary drug delivery. The dry powder NIMs technology improves on previous inhaled chemotherapy platforms designed as liquid formulations. Dry powder microparticles were created through the process of spray drying; a protocol detailing the formulation of NIMs dry powder is included as a separate chapter in this book. Dry powder NIMs containing fluorescent nanoparticles and magnetically-responsive superparamagnetic iron oxide nanoparticles are intratracheally delivered (insufflated) in the presence of a magnetic field and targeted to the left lung of mice. The targeting efficiency of dry powder NIMs is compared to the targeting efficiency of liquid NIMs to demonstrate the superiority of dry power targeting platforms. Targeting is assessed using fluorescence associated with NIMs detected in the mouse trachea, left lung, and right lung by an in vivo imaging system.
Sandia National Laboratories, Albuquerque, NM, USA.
Amber A
AA
McBride
Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Suite 208, 2705 Frontier Ave NE, Albuquerque, NM, 87106, USA.
Dominique N
DN
Price
Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Suite 208, 2705 Frontier Ave NE, Albuquerque, NM, 87106, USA. pmuttil@salud.unm.edu.
Pavan
P
Muttil
D000280:Administration, Inhalation; D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems; D007442:Intubation, Intratracheal; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice
D004337:Drug Carriers; D058185:Magnetite Nanoparticles
Dry powder; Insufflation; Intratracheal delivery; Iron oxide nanoparticles; Nano-in-microparticles; Pulmonary delivery; Superparamagnetism; Targeted drug delivery