From the research laboratory to the database: the Caenorhabditis elegans kinome in UniProtKB.
Protein kinases form one of the largest protein families and are found in all species, from viruses to humans. They catalyze the reversible phosphorylation of proteins, often modifying their activity and localization. They are implicated in virtually all cellular processes and are one of the most intensively studied protein families. In recent years, they have become key therapeutic targets in drug development as natural mutations affecting kinase genes are the cause of many diseases. The vast amount of data contained in the primary literature and across a variety of biological data collections highlights the need for a repository where this information is stored in a concise and easily accessible manner. The UniProt Knowledgebase meets this need by providing the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information. Here, we describe the expert curation process for kinases, focusing on the Caenorhabditis elegans kinome. The C. elegans kinome is composed of 438 kinases and almost half of them have been functionally characterized, highlighting that C. elegans is a valuable and versatile model organism to understand the role of kinases in biological processes.
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, U.K. rzaru@ebi.ac.uk.
Rossana
R
Zaru
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, U.K.
Michele
M
Magrane
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, U.K.
Claire
C
O'Donovan
D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D003067:Coenzymes / Q000235:genetics / Q000378:metabolism; D030562:Databases, Protein; D005786:Gene Expression Regulation; D063990:Gene Ontology; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D011494:Protein Kinases / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D020543:Proteome / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D040901:Proteomics; D015398:Signal Transduction; D014584:User-Computer Interface
D029742:Caenorhabditis elegans Proteins; D003067:Coenzymes; D020543:Proteome; D011494:Protein Kinases
UniProtKB; curation; database; kinase