Role of TRPV channels in regulating various pancreatic β-cell functions: Lessons from in vitro studies.
Pancreatic β-cell functions are regulated by a variety of endogenous and exogenous factors. Calcium is one of the most potent triggers of β-cell growth, insulin production and exocytosis. Recently, others and we showed that TRPV channels are expressed in insulin producing cell lines and/or primary β-cells. These channels modulate calcium ions, insulin secretion and cell proliferation. Besides the classical roles of TRPV channels in the sensory system, there are also novel functions described in non-excitable cells such as in insulin-producing β-cells. This review summarises the current knowledge about the expression and the role of TRPV channels in controlling β-cell functions based upon studies performed in isolated primary β-cells as well as permanent β-cell models.
Department of Animal Physiology and Biochemistry, Poznań University of Life Sciences.
Marek
M
Skrzypski
Maria
M
Billert
Stefan
S
Mergler
Noushafarin
N
Khajavi
Krzysztof W
KW
Nowak
Mathias Z
MZ
Strowski
D000818:Animals; D016923:Cell Death; D049109:Cell Proliferation; D006801:Humans; D007328:Insulin / Q000096:biosynthesis; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism*; D008954:Models, Biological; D050916:TRPV Cation Channels / Q000378:metabolism*
D007328:Insulin; D050916:TRPV Cation Channels