Centrosome Amplification and Cancer: A Question of Sufficiency.
Centrosome amplification is a common feature of many types of cancer, but whether it is a cause or consequence is hotly debated. In this issue of Developmental Cell, Levine et al. (2017) provide strong evidence that centrosome amplification is sufficient to initiate tumorigenesis in a mouse model.
Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK. Electronic address: jordan.raff@path.ox.ac.uk.
Jordan W
JW
Raff
Institut Curie, CNRS UMR144, 12 Rue Lhomond, 75005 Paris, France. Electronic address: renata.basto@curie.fr.
Renata
R
Basto
D000818:Animals; D002471:Cell Transformation, Neoplastic; D018385:Centrosome; D009369:Neoplasms