Formulation of Polyherbal Patches Based on Polyvinyl Alcohol and Hydroxypropylmethyl Cellulose: Characterization and In Vitro Evaluation.
The purpose of this research was to prepare and characterize polyherbal patches made from polyvinyl alcohol (PVA) and hydroxypropylmethyl cellulose (HPMC) with glycerine as a plasticizer. Polyherbal extracts were Luk-Pra-Kob recipes extracted with 95% ethanol. They were prepared by mixing the polymer solutions and glycerine in a beaker; subsequently, the polyherbal extracts were homogeneously mixed. Then, they were transferred into a Petri dish and dried in a hot-air oven at 70 ± 2°C for 5 h. The dry polyherbal patches were evaluated for physicochemical properties by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and a scanning electron microscope. They were studied for in vitro release and skin permeation of the marker active compound (E)-4-(3',4'-dimethoxyphenyl)but-3-en-l-ol (compound D) using a modified Franz-type diffusion cell. The polyherbal patches made from PVA as a matrix layer were homogeneous, smooth, and compact relative to HPMC-containing polyherbal patches. The selected polyherbal patches made from PVA produced a release profile with an initial burst effect in which compound D release was 74.21 ± 6.13% within 8 h, but compound D could permeate the pig skin only 37.28 ± 5.52% and was highly accumulated in newborn pig skin at 35.90 ± 6.72%. The in vitro release and skin permeation kinetics of compound D were fitted to the Higuchi model. The polyherbal patches made from PVA could be suitably used for herbal medicine application.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand. jirapornchai.s@rsu.ac.th.|The Herbal Medicinal Products Research and Development Center (Cooperation between Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine), Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand. jirapornchai.s@rsu.ac.th.
Jirapornchai
J
Suksaeree
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand.
Noramon
N
Nawathong
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand.
Rinrada
R
Anakkawee
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand.
Wiwat
W
Pichayakorn
D000818:Animals; D002482:Cellulose / Q000737:chemistry; D065546:Drug Liberation; D065347:Hypromellose Derivatives / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013552:Swine
D010936:Plant Extracts; D065347:Hypromellose Derivatives; D011142:Polyvinyl Alcohol; D002482:Cellulose
(E)-4-(3′,4′-dimethoxyphenyl)but-3-en-l-ol; Luk-Pra-Kob; Thai herbal compress ball; matrix patches; polyherbal patches