Localization of Unknown Primary Site with68Ga-DOTATOC PET/CT in Patients with Metastatic Neuroendocrine Tumor.
Localization of the site of the unknown primary tumor is critical for surgical treatment of patients presenting with neuroendocrine tumor (NET) with metastases.Methods:Forty patients with metastatic NET and unknown primary site underwent68Ga-DOTATOC PET/CT in a single-site prospective study. The68Ga-DOTATOC PET/CT was considered true-positive if the positive primary site was confirmed by histology or follow-up imaging. The scan was considered false-positive if no primary lesion was found corresponding to the68Ga-DOTATOC-positive site. All negative scans for primary tumor were considered false-negative. A scan was classified unconfirmed if68Ga-DOTATOC PET/CT suggested a primary, however, no histology was obtained and imaging follow-up was not confirmatory.Results:The true-positive, false-positive, false-negative, and unconfirmed rates for unknown primary tumor were 38%, 7%, 50%, and 5%, respectively.Conclusion:68Ga-DOTATOC PET/CT is an effective modality in the localization of unknown primary in patients with metastatic NET.
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa yusuf-menda@uiowa.edu.
Yusuf
Y
Menda
Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Thomas M
TM
O'Dorisio
Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa.
James R
JR
Howe
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Michael
M
Schultz
Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Joseph S
JS
Dillon
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
David
D
Dick
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
G Leonard
GL
Watkins
Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Timothy
T
Ginader
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
David L
DL
Bushnell
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
John J
JJ
Sunderland
Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa; and.
Gideon K D
GKD
Zamba
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Michael
M
Graham
Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
M Sue
MS
O'Dorisio
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000000981:diagnostic imaging* / Q000473:pathology; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary*; D015588:Observer Variation; D015282:Octreotide / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D015282:Octreotide
68Ga-DOTATOC; PET/CT; neuroendocrine; neuroendocrine tumor; unknown primary