Long noncoding RNA activated by TGF-β in human cancers: A meta-analysis.
BACKGROUND
Because long non-coding RNA ATB (activated by TGF-β) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors.


METHODS
We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from inception until November 15, 2016 and identified eight studies with 818 cancer patients for the meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between lncRNA-ATB expression and overall survival (OS), recurrence -free survival (RFS), disease-free survival (DFS). We also use RevMan5.3 software to calculate odds ratio (ORs) to assess the association between lncRNA-ATB expression and pathological parameters including lymph node metastasis (LNM), distant metastasis (DM) and tumor stage.


RESULTS
Our analysis showed that increased lncRNA-ATB expression was associated with OS (HR=2.82, 95% CI:1.98-4.00, P<0.00001), DFS (HR=2.75, 95% CI:1.73-4.38, P<0.0001), RFS(HR=3.96, 95% CI:2.30-6.81, P<0.00001), LNM (OR=4.07, 95% CI 1.74-9.53, P=0.001), DM (OR=3.21, 95% CI 1.06-9.72, P=0.04) and high tumor stage (OR=2.81, 95% 1.78-4.43, P<0.0001) in patients with other types of cancers that excluded pancreatic cancer.


CONCLUSIONS
Meta-analysis demonstrated that increased lncRNA-ATB expression can be a useful prognostic biomarker in human cancer.
Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China.
Yang-Hua
YH
Fan
Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China.
Chen-Xing
CX
Ji
Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China.
Bing
B
Xu
Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China.
Heng-Yi
HY
Fan
Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China. Electronic address: chengzjsjwk2016@163.com.
Zu-Jue
ZJ
Cheng
Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China. Electronic address: xingenzhu_2015@sina.com.
Xin-Gen
XG
Zhu
D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D062085:RNA, Long Noncoding; D016212:Transforming Growth Factor beta
LncRNA-ATB; Meta-analysis; Metastasis; Neoplasm; Prognosis