Human Dosimetry of theN-Methyl-d-Aspartate Receptor Ligand11C-GMOM.
The methylguanidine derivative11C-GMOM (11C-labeledN-(2-chloro-3-thiomethylphenyl)-N'-(3-methoxyphenyl)-N'-methylguanidine) has been used successfully to quantifyN-methyl-d-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the11C-GMOM radiation dose in healthy humans.Methods:After11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose.Results:The mean absorbed radiation doses in source organs ranged from 7.7 μGy·MBq-1in the brain to 12.7 μGy·MBq-1in the spleen. The effective dose (±SD) was 4.5 ± 0.5 μSv·MBq-1Conclusion:The effective dose of11C-GMOM is at the lower end of the range seen for other11C-labeled ligands, allowing for serial PET scanning in a single subject.
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands jaspervanderaart@gmail.com.
Jasper
J
van der Aart
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Thalia F
TF
van der Doef
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Paul
P
Horstman
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Marc C
MC
Huisman
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Robert C
RC
Schuit
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Arthur
A
van Lingen
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Albert D
AD
Windhorst
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Bart N M
BNM
van Berckel
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Adriaan A
AA
Lammertsma
D000328:Adult; D002250:Carbon Radioisotopes; D005260:Female; D006146:Guanidines / Q000378:metabolism* / Q000493:pharmacokinetics; D064368:Healthy Volunteers; D006801:Humans; D008024:Ligands; D008297:Male; D049268:Positron-Emission Tomography; D011874:Radiometry; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D006146:Guanidines; D008024:Ligands; C499128:N-(2-chloro-5-thiomethylphenyl)-N'-(3-methoxyphenyl)-N'-methylguanidine; D016194:Receptors, N-Methyl-D-Aspartate
11C; NMDA; PET; dosimetry