Rapid diagnostics of urinary iodine using a portable EDXRF spectrometer.
A method for urinary iodine diagnostics using a portable energy-dispersion X-ray fluorescent (EDXRF) spectrometer is proposed. The principle of the method consists in excitation of the sample atoms fluorescence by the energy spectrum intentionally formed from the spectrum of an X-ray tube using an optimized X-ray scheme. The optimization by the criterion of the minimum detection limit for L-series iodine fluorescence lines included the calculation of optimal atomic numbers for materials of a re-radiator and a filter, and their thicknesses, the collimation system parameters, and an X-ray tube voltage. Experimentally achieved detection limits were 45 and 75 μg/L by I-Lα and I-Lβ lines, respectively, at the theoretically extreme value 30 μg/L. This sensitivity is found to be sufficient for urinary iodine diagnostics in the range from 50 to 200 μg/L. The results obtained from different patients have shown the satisfactory convergence for the iodine concentration determination by Lα and I-Lβ fluorescence lines. The simple sample preparation procedure and comparably small sizes of the apparatus allows rapid researches directly in clinical settings.
National Technical University "KharkivPolytechnic Institute" Frunze, Kharkiv, Ukraine.
I F
IF
Mikhailov
National Technical University "KharkivPolytechnic Institute" Frunze, Kharkiv, Ukraine.
A A
AA
Baturin
National Technical University "KharkivPolytechnic Institute" Frunze, Kharkiv, Ukraine.
A I
AI
Mikhailov
National Technical University "KharkivPolytechnic Institute" Frunze, Kharkiv, Ukraine.
S S
SS
Borisova
National Technical University "KharkivPolytechnic Institute" Frunze, Kharkiv, Ukraine.
M V
MV
Reshetnyak
Kharkiv National Medical University Nauki ave., Kharkiv, Ukraine.
D I
DI
Galata
D002138:Calibration; D006801:Humans; D007455:Iodine / Q000652:urine*; D012680:Sensitivity and Specificity; D013052:Spectrometry, X-Ray Emission / Q000379:methods*
D007455:Iodine
X-ray fluorescence spectrum; rapid diagnostics.; selective excitation; urinary iodine