Microbiome sharing between children, livestock and household surfaces in western Kenya.
The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of gut microbiome structure, we assessed microbial sharing within households in western Kenya by sequencing 16S rRNA libraries of fecal samples from children and cattle, cloacal swabs from chickens, and swabs of household surfaces. Among the 156 households studied, children within the same household significantly shared their gut microbiome with each other, although we did not find significant sharing of gut microbiome across host species or household surfaces. Higher gut microbiome diversity among children was associated with lower wealth status and involvement in livestock feeding chores. Although more research is necessary to identify further drivers of microbiota development, these results suggest that the household should be considered as a unit. Livestock activities, health and microbiome perturbations among an individual child may have implications for other children in the household.
University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, Washington, United States of America.|Washington State University, Paul G. Allen School for Global Animal Health, Pullman, Washington, United States of America.
Emily
E
Mosites
Washington State University, Paul G. Allen School for Global Animal Health, Pullman, Washington, United States of America.
Matt
M
Sammons
Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.
Elkanah
E
Otiang
University of Washington, Department of Genome Sciences, Seattle, Washington, United States of America.
Alexander
A
Eng
University of Washington, Department of Genome Sciences, Seattle, Washington, United States of America.
Cecilia
C
Noecker
University of Washington, Department of Genome Sciences, Seattle, Washington, United States of America.
Ohad
O
Manor
University of Washington, Department of Genome Sciences, Seattle, Washington, United States of America.
Sarah
S
Hilton
Washington State University, Paul G. Allen School for Global Animal Health, Pullman, Washington, United States of America.
Samuel M
SM
Thumbi
Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.
Clayton
C
Onyango
University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, Washington, United States of America.
Gemina
G
Garland-Lewis
Washington State University, Paul G. Allen School for Global Animal Health, Pullman, Washington, United States of America.
Douglas R
DR
Call
Washington State University, Paul G. Allen School for Global Animal Health, Pullman, Washington, United States of America.
M Kariuki
MK
Njenga
University of Washington, Department of Global Health, Seattle, Washington, United States of America.|University of Washington, Department of Medicine, Seattle, Washington, United States of America.|University of Washington, Department of Epidemiology, Seattle, Washington, United States of America.
Judith N
JN
Wasserheit
Washington State University, Paul G. Allen School for Global Animal Health, Pullman, Washington, United States of America.
Jennifer A
JA
Zambriski
University of Washington, Department of Global Health, Seattle, Washington, United States of America.|University of Washington, Department of Medicine, Seattle, Washington, United States of America.|University of Washington, Department of Epidemiology, Seattle, Washington, United States of America.|University of Washington, Department of Pediatrics, Seattle, Washington, United States of America.
Judd L
JL
Walson
Washington State University, Paul G. Allen School for Global Animal Health, Pullman, Washington, United States of America.
Guy H
GH
Palmer
Centers for Disease Control and Prevention, Division of Global Health Protection, Center for Global Health, Atlanta, Georgia, United States of America.
Joel
J
Montgomery
University of Washington, Department of Genome Sciences, Seattle, Washington, United States of America.|University of Washington, Department of Computer Science and Engineering, Seattle, Washington, United States of America.|Santa Fe Institute, Santa Fe, New Mexico, United States of America.
Elhanan
E
Borenstein
Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.
Richard
R
Omore
University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, Washington, United States of America.|University of Washington, Department of Global Health, Seattle, Washington, United States of America.|University of Washington, Department of Family Medicine, Seattle, Washington, United States America.
Peter M
PM
Rabinowitz
D000818:Animals; D044822:Biodiversity; D002417:Cattle / Q000382:microbiology; D002645:Chickens / Q000382:microbiology; D002675:Child, Preschool; D005191:Family Characteristics; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000235:genetics; D006801:Humans; D007630:Kenya; D058751:Livestock / Q000382:microbiology*; D008297:Male; D011200:Poultry / Q000382:microbiology; D012336:RNA, Ribosomal, 16S; D012424:Rural Population
D012336:RNA, Ribosomal, 16S