Recent Advances in the Chemistry of Pentafulvenes.
Pentafulvenes are a unique class of compounds that originally attracted attention due to their propensity to display nonbenzenoid aromaticity. Subsequently, they were recognized as valuable synthons for the construction of a wide range of compounds by virtue of their ability to display multiple cycloaddition profiles. Naturally, this area of organic chemistry has experienced rapid growth over the last five decades, fueled by elegant work showcasing the unique reactivity of pentafulvenes in a plethora of cycloaddition reactions. In this Review, we have attempted to provide a systematic account of the methods for the generation of pentafulvenes, their rich and varied cycloaddition chemistry, organometallic reactions, and theoretical studies that support their versatility. Further, we have highlighted their applications in the synthesis of a variety of complex structural frameworks. It is our conviction that this Review will be useful to a wide range of chemists, and will spur further research in this promising area.
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) , Trivandrum 695 019, Kerala, India.
Preethanuj
P
Preethalayam
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) , Trivandrum 695 019, Kerala, India.
K Syam
KS
Krishnan
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) , Trivandrum 695 019, Kerala, India.
Sreeja
S
Thulasi
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) , Trivandrum 695 019, Kerala, India.
S Sarath
SS
Chand
Institut de Chimie Moléculaire de Reims CNRS (UMR 7312) and Université de Reims Champagne-Ardenne , Reims 51687 Cedex 2, France.
Jomy
J
Joseph
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) , Trivandrum 695 019, Kerala, India.
Vijay
V
Nair
Institut de Chimie Moléculaire de Reims CNRS (UMR 7312) and Université de Reims Champagne-Ardenne , Reims 51687 Cedex 2, France.
Florian
F
Jaroschik
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) , Trivandrum 695 019, Kerala, India.
K V
http://orcid.org/0000-0001-8909-3175
KV
Radhakrishnan