Breaking Down Neighbors to Fuel Tumorigenesis.
Autophagy supports cell growth and survival autonomously by recycling intracellular proteins and/or organelles. Reporting in Nature, Katheder and colleagues (2017) find that tumors trigger non-autonomous autophagy in neighboring cells and distant organs, thus fueling tumor growth and metastasis. This opens new avenues for understanding and manipulating cancers through cell-cell communication.
Department of Developmental Biology, Stanford School of Medicine, Beckman Center, 279 Campus Drive B300, Stanford, CA 94305, USA. Electronic address: jvaughen@stanford.edu.
John
J
Vaughen
Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoecho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: igaki@lif.kyoto-u.ac.jp.
Tatsushi
T
Igaki
D001343:Autophagy; D063646:Carcinogenesis; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic; D006801:Humans; D009369:Neoplasms