Effect of Prothionamide in Leprosy Clinico-bacteriological Observations.
Mouse footpad studies indicate the strong, I bactericidal property of prothionamide against M. leprae supported with limited clinical experience. Based on the recommendation made by the Expert Committee on Experimental Chemotherapy, Mexico as well as by Ellard, 6 L L and 2 BL cases were administered prothionamide alone 500 mg and 250-375 mg daily for a period of 3 -6 months. Maximum fall of MI up to 99% was observed by the end of second month correlated with marked clinical improvement.
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Revankar
Nilima J
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Samant
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Ganapati