Microbial Molecules from the Multitudes within Us.
Chemists demonstrate in Cell that intestinal microbes are capable of synthesizing metabolites that look like clinical drugs and inhibit human targets. These results provide molecular resolution to the field of mammalian-microbial mutualism and highlight the potential for natural product discovery from the multitudes within us.
Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: redinbo@unc.edu.
Matthew R
MR
Redinbo
D000818:Animals; D000069196:Gastrointestinal Microbiome; D006801:Humans; D013559:Symbiosis
GI microbiota; Koch’s Postulates; human microbiome; human therapeutics; microbial metabolites; natural products