HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function.
Histone deacetylation, reciprocally mediated by histone deacetylases (HDAC) and acetyltransferases, represents one major form of post-translational modification. Previous research indicates that HDACs play an essential regulatory role in the development of various immune cells. However, the specific function of individual HDACs remains largely unexplored. HDAC4, a member of class II HDACs, profoundly investigated in the nervous system, while the expression profile and function of HDAC4 in T cells are barely known. For the first time, we report here that HDAC4 is expressed in the multiple T cell lineages. Using T-cell-specific HDAC4-deficient mice, we discovered that lack of HDAC4 did not alter the frequencies of conventional T cells, invariant NKT (iNKT) cells or regulatory T cells within both the thymus and secondary lymphoid organs. Moreover, conventional T cells and iNKT cells from wild-type and HDAC4-deficient mice displayed no significant difference in cytokine production. In conclusion, our results imply that under steady stage, HDAC4 is not required for the development and function of multiple T cell lineages, including conventional T cells and iNKT cells.
Department of Dermatology, Xiang-Ya Hospital of Central South University, Changsha, Hunan, China.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
Queping
Q
Liu
Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
Xilin
X
Zhang
Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
Congcong
C
Yin
Department of Dermatology, Xiang-Ya Hospital of Central South University, Changsha, Hunan, China.
Xing
X
Chen
Department of Neurology, Henry Ford Health System, Detroit, MI, USA.
Zhenggang
Z
Zhang
Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Stephen
S
Brown
Department of Dermatology, Xiang-Ya Hospital of Central South University, Changsha, Hunan, China.
Hongfu
H
Xie
Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Li
L
Zhou
Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Qing-Sheng
QS
Mi
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology*; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006655:Histone Deacetylases / Q000276:immunology*; D038041:Lymphopoiesis / Q000276:immunology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D016133:Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
C498618:Hdac5 protein, mouse; D006655:Histone Deacetylases
HDAC4; Immune response; Immunity; Immunology and Microbiology Section; conventional T cells; development; invariant NKT cells; polarization