Effects of resistance training at different loads on inflammatory markers in young adults.
OBJECTIVE
Suppressing inflammaging at an early stage in life via exercise might prevent chronic diseases later in life. The aim was to investigate the influence of resistance training at different external loads on inflammatory markers in healthy young adults.


METHODS
Serum was collected for basal levels of cytokines (IL-1beta, IL-6, IL-8, sTNFR1, IL-1RA, IL-10 and GM-CSF) before and after 9 weeks exercise from 36 young (22 ± 2 years) healthy subjects who were randomized to three times weekly supervised resistance training at either HImax(n = 12, 1 × 10-12 repetitions at 80% 1RM), LO (n = 12, 1 × 10-12 repetitions at 40% 1RM), or LOmax(n = 12, 1 × 10-12 repetitions at 40% 1RM preceded by 60 repetitions at 20-25% 1RM) respectively.


RESULTS
Overall, IL-8 increased (p < 0.001) and IL-6 decreased (p = 0.001) after training, but no significant time*group interaction was found (respectively, p = 0.283 and p = 0.058 for IL-8 and IL-6). When analyzed separately, IL-8 increased significantly in HImax(p = 0.022) and LOmax(p = 0.024); and IL-6 decreased significantly in LOmax(p = 0.009) and LO (p = 0.013). No significant overall time effect was observed for sTNFR1 and IL-1RA; however, in HImaxsTNFR1 (p = 0.031) and IL-1RA (p = 0.014) increased significantly, but remained unchanged in LOmaxand LO. IL-1beta, IL-10 and GM-CSF levels remained undetectable in most participants.


CONCLUSIONS
Nine weeks of resistance training-irrespective of the external load-have beneficial effects on circulating IL-8 and IL-6. In addition, training at high external load increases the anti-inflammatory cytokines sTNFR1 and IL-1RA. The results of this study show that resistance training has anti-inflammatory effects in healthy young persons and that the response of the different inflammatory mediators depends on the magnitude of the external load.
Gerontology Department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.|Frailty in Ageing Research (FRIA) Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.
Louis Nuvagah
LN
Forti
Physical Activity, Sports and Health Research Group, Department of Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Tervuursevest 101, 3001, Leuven, Belgium.
Evelien
E
Van Roie
Gerontology Department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.|Frailty in Ageing Research (FRIA) Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.
Rose
R
Njemini
Radiology Section, Department of Morphology and Medical Imaging, Faculty of Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Walter
W
Coudyzer
Gerontology Department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.|Frailty in Ageing Research (FRIA) Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.|Department of Geriatrics, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Ingo
I
Beyer
Physical Activity, Sports and Health Research Group, Department of Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Tervuursevest 101, 3001, Leuven, Belgium.
Christophe
C
Delecluse
Gerontology Department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. ivan.bautmans@vub.be.|Frailty in Ageing Research (FRIA) Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. ivan.bautmans@vub.be.|Department of Geriatrics, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium. ivan.bautmans@vub.be.
Ivan
http://orcid.org/0000-0002-6820-9586
I
Bautmans
D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000517:prevention & control; D008297:Male; D055070:Resistance Training; D055815:Young Adult
D015415:Biomarkers; D016207:Cytokines
Cytokines; Resistance training; Training load; Young adult