A spontaneous high-grade undifferentiated mammary carcinoma in a seven-week-old female rat.
The present work describes a rare case of a spontaneous high-grade carcinoma in a seven-week-old Sprague-Dawley female rat that had been included in the control group of an assay of mammary carcinogenesis. The mass was detected at 50days of age, it grown quickly and the animal was humanely sacrificed eight days later. The tumor was located in the left cervical region, in the vicinity of the left submandibular and sublingual glands. It was soft and reddish and had several dens with a bloody content. The tumor was PAS negative and exhibited immunostaining for ER-α. The histopathologic and immunohistochemical data are suggestive of a high-grade carcinoma from mammary gland. It was the first report of a spontaneous mammary tumor in such a young rat.
Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro, UTAD, 5001-911 Vila Real, Portugal(1); Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), UTAD, 5001-911 Vila Real, Portugal(1); Animal and Veterinary Research Center (CECAV), School of Agrarian and Veterinary Sciences, UTAD, 5001-911 Vila Real, Portugal(1); Organic Chemistry, Natural Products and Foodstuffs (QOPNA), Mass Spectrometry Center, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal(2). Electronic address: anafaustino.faustino@sapo.pt.
Ana I
AI
Faustino-Rocha
Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro, UTAD, 5001-911 Vila Real, Portugal(1); Animal and Veterinary Research Center (CECAV), School of Agrarian and Veterinary Sciences, UTAD, 5001-911 Vila Real, Portugal(1).
Adelina
A
Gama
Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro, UTAD, 5001-911 Vila Real, Portugal(1); Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), UTAD, 5001-911 Vila Real, Portugal(1).
Paula A
PA
Oliveira
Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), UTAD, 5001-911 Vila Real, Portugal(1); Área de Patología, Decanato de Ciencias Veterinarias, Universidad Centroccidental "Lisandro Alvarado", UCLA, 3023 Lara, Venezuela(3).
Antonieta
A
Alvarado
Organic Chemistry, Natural Products and Foodstuffs (QOPNA), Mass Spectrometry Center, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal(2).
Rita
R
Ferreira
Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro, UTAD, 5001-911 Vila Real, Portugal(1); Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), UTAD, 5001-911 Vila Real, Portugal(1).
Mário
M
Ginja
D000818:Animals; D002277:Carcinoma / Q000662:veterinary*; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
Female rat; Mammary carcinoma; Young