The Use of Lipid Peroxidation Expression as a Biomarker for the Molecular Damage in the Critically Ill Polytrauma Patient.
BACKGROUND
The critically ill polytrauma patient, apart from the primary, traumatic injuries and the secondary, port-traumatic injuries, presents with a series of molecular disasters. Dysfunctions of the biochemical pathways and molecular damage add to the worsening of the clinical status of these patients, one of the most well-known molecular phenomena being oxidative stress (OS), responsible for an escalation of the inflammatory status, multiple infections, and multiple organ dysfunction syndrome (MODS).


METHODS
For this study was analysed the literature available on PubMed and Scopus. The key words used in the search were "oxidative stress", "lipid peroxidation", "critically ill", "polytrauma patients", and "biomarkers oxidative stress".


RESULTS
For the study we selected 47 science articles. The oxidative attack on lipids is responsible for the biosynthesis of an increased quantity of free radicals (FR), which further intensifies and aggravates the redox status in these patients.


CONCLUSIONS
One of the most aggressive redox mechanisms related to lipid molecules is known as lipid peroxidation (LPOX).
Florin G
FG
Horhat
Alexandru F
AF
Rogobete
Marius
M
Papurica
Dorel
D
Sandesc
Sonia
S
Tanasescu
Victor
V
Dumitrascu
Monica
M
Licker
Razvan
R
Nitu
Carmen A
CA
Cradigati
Mirela
M
Sarandan
Ovidiu
O
Boruga
Ciprian D
CD
Crisan
Emil
E
Ungureanu
Daniela M
DM
Popa
Sonia E
SE
Popovici
Ovidiu H
OH
Bedreag
D015415:Biomarkers / Q000378:metabolism; D016638:Critical Illness; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D009104:Multiple Trauma / Q000150:complications / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
D015415:Biomarkers; D005609:Free Radicals