Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy.
Abnormal fatty acid metabolism and the related enzymes had been observed to be associated with psychiatric disorders. We investigated FADS gene family genetic polymorphisms and variations of lipid profiles in patients with heroin dependence receiving 6-month methadone maintenance therapy (MMT). We recruited 89 MMT drug abusers and analyzed 3 tag single nucleotide polymorphisms (SNPs) from Fatty acid desaturases (FADS), FADS1, FADS2 and FADS3. The fatty acid profiles of erythrocyte membranes were analyzed based on genetic variations. Six-month MMT therapy were significantly associated with decreased C20: 5n3 and C22:4n6 levels in the whole group of drug abusers. The decreases of C22: 6n3 after MMT therapy were associated with specific genetic variations, including FADS1 C/C, FADS2 T/T and FADS3 C/C genotypes. The variations on n3 and n6 PUFA composition were significantly shown in different alleles of FADS in MMT drug abusers. Further studies are needed to elucidate the role of fatty acid metabolism on rehabilitation by MMT.
Department of Nutrition and Institute of Nutrition, China Medical University, Taiwan.
Hui-Ting
HT
Yang
Department of Public Health, China Medical University, Taiwan.
Ruey-Yun
RY
Wang
School of Nutrition and Health Sciences, Taipei Medical University, Taiwan.
Shih-Yi
SY
Huang
Department of Psychiatry and Mind-Body Interface Lab (MBI Lab), China Medical University Hospital, Taichung, Taiwan.
Chieh-Liang
CL
Huang
Department of Psychiatry and Mind-Body Interface Lab (MBI Lab), China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan. Electronic address: cobolsu@gmail.com.
Kuan-Pin
KP
Su
D000293:Adolescent; D000328:Adult; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005227:Fatty Acids / Q000032:analysis / Q000097:blood; D005260:Female; D006556:Heroin Dependence / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D000071184:Pharmacogenomic Variants; D020641:Polymorphism, Single Nucleotide; D016896:Treatment Outcome; D055815:Young Adult
D000090943:Delta-5 Fatty Acid Desaturase; D005227:Fatty Acids; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C533241:FADS2 protein, human; C545859:FADS3 protein, human; D008691:Methadone
DHA; FADS gene polymorphism; Heroin; Methadone; PUFA