Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study.
Neuroimaging studies investigating dopamine (DA) function widely support the hypothesis of presynaptic striatal DA hyperactivity in schizophrenia. However, published data on the striatal DA transporter (DAT) appear less consistent with this hypothesis, probably partly due to methodological limitations. Moreover, DAT in extrastriatal regions has been very poorly investigated in the context of schizophrenia. In order to address these issues, we used a high resolution positron emission tomograph and the selective DAT radioligand [11C]PE2I, coupled with a whole brain voxel-based analysis method to investigate DAT availability in striatal but also extra-striatal regions in 21 male chronic schizophrenia patients compared to 30 healthy male controls matched by age. We found higher DAT availability in schizophrenia patients in midbrain, striatal, and limbic regions. DAT availability in amygdala/hippocampus and putamen/pallidum was positively correlated with hallucinations and suspiciousness/persecution, respectively. These results are consistent with an increase of presynaptic DA function in patients with schizophrenia, and support the involvement of both striatal and extrastriatal DA dysfunction in positive psychotic symptoms. The study also highlights the whole brain voxel-based analysis method to explore DA dysfunction in schizophrenia.
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.|GH Nord Essonne, Psychiatry Department 91G16, Orsay Hospital, Orsay, France.
Eric
E
Artiges
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.|Laboratoire Imagerie Moléculaire In Vivo (IMIV), CEA, INSERM, CNRS, Paris Sud University-Paris Saclay University, CEA-SHFJ, Orsay, France.
Claire
C
Leroy
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.
Manon
M
Dubol
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.
Marie
M
Prat
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.
Audrey
A
Pepin
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.
Audrey
A
Mabondo
Psychiatry Department, Paul Guiraud Hospital, Villejuif, France.
Renaud
R
de Beaurepaire
Psychiatry Department, AP-HP, Corentin Celton Hospital, Issy-les-Moulineaux, France.
Béatrice
B
Beaufils
Psychiatry Department, Barthélémy Durand Hospital, Etampes, France.
Jean-Pierre
JP
Korwin
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.
André
A
Galinowski
AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France.
Marc-Antoine
MA
D'Albis
Nuclear Medicine Department, Bretonneau Hospital, CHRU Tours, France.
Maria-João
MJ
Santiago-Ribeiro
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.|APHP Tarnier Hospital, Psychiatry Department, Cochin Hospital, Paris, France.
Bernard
B
Granger
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.|APHP Tarnier Hospital, Psychiatry Department, Cochin Hospital, Paris, France.|INSERM U1130 Research Unit, CNRS UMR 8246, UPMC UM CR18, Paris, France.
Eleni T
ET
Tzavara
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.
Jean-Luc
JL
Martinot
INSERM, Research Unit 1000 "Neuroimaging and Psychiatry", Paris Sud University-Paris Saclay University and Paris Descartes University, Orsay, France.|Psychiatry Department, Barthélémy Durand Hospital, Etampes, France.
Christian
C
Trichard
D000328:Adult; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D055815:Young Adult
D050483:Dopamine Plasma Membrane Transport Proteins
DAT; neuroimaging; positive symptoms; psychosis