Novel fluorinated ligands for gold nanoparticle labelling with applications in19F-MRI.
Novel fluorinated ligands for gold nanoparticle labelling have been designed and synthesised. Several types of gold nanoparticles have been prepared in the presence of these fluorinated ligands alone, or in combination with non-fluorinated ligands. Their colloidal stability in water and other solvents was tested and the magnetic resonance properties of the so-obtained nanoparticles were also assessed in detail.1H and19F-NMR spectra were evaluated and MRI phantoms of the most promising nanoparticles were successfully measured in19F-MRI. The MRI signal to noise ratio was related to the fluorine concentration and compared with ICP-MS data to correlate the real concentration of fluorine grafted onto the nanoparticles with the actually active fluorine in MRI.
CIC biomaGUNE, Paseo Miramon 182, 20014 Donostia - San Sebastian, Spain. mcarril@cicbiomagune.es.
Olatz
O
Michelena
CIC biomaGUNE, Paseo Miramon 182, 20014 Donostia - San Sebastian, Spain. mcarril@cicbiomagune.es.
Daniel
D
Padro
CIC biomaGUNE, Paseo Miramon 182, 20014 Donostia - San Sebastian, Spain. mcarril@cicbiomagune.es.
Carolina
C
Carrillo-Carrión
Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CiQUS) y Departamento de Física de Partículas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Pablo
P
Del Pino
CIC biomaGUNE, Paseo Miramon 182, 20014 Donostia - San Sebastian, Spain. mcarril@cicbiomagune.es.
Jorge
J
Blanco
CIC biomaGUNE, Paseo Miramon 182, 20014 Donostia - San Sebastian, Spain. mcarril@cicbiomagune.es.
Blanca
B
Arnaiz
CIC biomaGUNE, Paseo Miramon 182, 20014 Donostia - San Sebastian, Spain. mcarril@cicbiomagune.es and Department of Physics, Philipps University of Marburg, Renthof 7, 35037 Marburg, Germany.
Wolfgang J
http://orcid.org/0000-0003-1672-6650
WJ
Parak
CIC biomaGUNE, Paseo Miramon 182, 20014 Donostia - San Sebastian, Spain. mcarril@cicbiomagune.es and Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain.
Mónica
http://orcid.org/0000-0002-1232-8658
M
Carril
D045744:Cell Line, Tumor; D003102:Colloids; D005462:Fluorine Radioisotopes; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D008024:Ligands; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D019047:Phantoms, Imaging; D059629:Signal-To-Noise Ratio
D003102:Colloids; D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; D008024:Ligands; D006046:Gold