Evaluation of dogs with genetic hyperuricosuria and urate urolithiasis consuming a purine restricted diet: a pilot study.
BACKGROUND
Urate urolithiasis is a common problem in breed homozygous for the mutation that results in hyperuricosuria. Low purine diets have been recommended to reduce purine intake in these dogs.


METHODS
A higher protein, purine restricted diet with water added was evaluated in dogs with genetic hyperuricosuria and a history of clinical urate urolithiasis over a one year time period. Dogs were evaluated at baseline and 2, 6, and 12 months after initiating the test diet. Bloodwork, urinalysis, abdominal ultrasound, body composition, and 24-h urinary purine metabolite analyses were performed.


RESULTS
Transient, mild, self-limited lower urinary tract signs were noted in only one dog on a single day, despite variable but usually mild and occasionally moderate amounts of echogenic bladder stones (<2-3 mm in size) in almost every dog at each visit. No significant differences were noted in urine specific gravity, urine pH, lean body condition score or body composition. Urinary uric acid concentration was lower on the test diet (p = 0.008), but 24-h uric acid excretions were similar (p = 0.220) compared to baseline. Significant differences between least squares mean plasma amino acid concentrations measured at the 0 and 12-month visits were found only for valine (p = 0.0119) and leucine (p = 0.0017).


CONCLUSIONS
This study suggests the use of a low purine, higher protein diet with added water may be beneficial as part of the management of dogs with genetic hyperuricosuria and history of clinical urate urolithiasis.
Departments of Veterinary Medicine and Epidemiology, Davis, CA, USA. jlwestropp@ucdavis.edu.
Jodi L
JL
Westropp
Molecular Biosciences, Davis, CA, USA.
Jennifer A
JA
Larsen
Department of Veterinary Surgery and Radiology, Davis, CA, USA.
Eric G
EG
Johnson
Population Health and Reproduction, Davis, CA, USA.
Dannika
D
Bannasch
Molecular Biosciences, Davis, CA, USA.
Andrea J
AJ
Fascetti
UC Davis School of Veterinary Medicine, One Shields Avenue, Davis, CA, 95616, USA.|Royal Canin Research & Development Center, Aimargues, France.
Vincent
V
Biourge
UC Davis School of Veterinary Medicine, One Shields Avenue, Davis, CA, 95616, USA.|Royal Canin Research & Development Center, Aimargues, France.
Yann
Y
Queau
D000596:Amino Acids / Q000097:blood; D000818:Animals; D001823:Body Composition; D004032:Diet / Q000662:veterinary*; D004283:Dog Diseases / Q000178:diet therapy*; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D008297:Male; D011687:Purines / Q000378:metabolism / Q000652:urine; D014527:Uric Acid / Q000652:urine; D052878:Urolithiasis / Q000178:diet therapy / Q000662:veterinary*; D014570:Urologic Diseases / Q000178:diet therapy / Q000662:veterinary*; D014867:Water
D000596:Amino Acids; D011687:Purines; D014867:Water; D014527:Uric Acid; C030985:purine
Canine; Diet; Urate; Urolithiasis