Evaluation of the effect of indomethacin and piroxicam administration before embryo transfer on pregnancy rate.
OBJECTIVE
The aim of this study was to evaluate the effect of non-steroidal anti-inflammatory drug (NSAID) administration before embryo transfer (ET) on pregnancy rates in women undergoing in vitro fertilization/intracytoplasmic sperm injection ET.


METHODS
Our study included 255 patients diagnosed with primary or secondary infertility caused by a male or tubal-related factor, endometriosis or unexplained factors. The patients were divided randomly into three groups. Two groups were administered oral piroxicam (10 mg capsules) or 100 mg indomethacin (rectal suppository), respectively, 1-2 h before ET. As a control, the third group did not receive any form of treatment before ET. Basal levels of follicle-stimulating hormone, luteinizing hormone, and level 17β-estradiol on the day of human chorionic gonadotropin administration, the collected and transferred number of embryos, and the number of grade A embryos obtained were determined in all patients.


RESULTS
The implantation, clinical pregnancy, and miscarriage rates of the groups were compared. The clinical pregnancy rate per ET and the implantation rate were 35.2% and 12.15% in the piroxicam group, 31.7% and 10.9% in the indomethacin group, and 32.9% and 12.5% in the control, respectively. The miscarriage rates of groups 1, 2 and 3 were 12%, 11.7% and 11.7%, respectively (P = 0.964). The differences in clinical pregnancy rates among the groups were not statistically significant (P = 0.887). There were also no significant differences in the implantation rates (P = 0.842).


CONCLUSIONS
These results suggest that NSAID administration before ET has no additional effect on pregnancy outcome in patients undergoing in vitro fertilization.
Department of Obstetrics and Gynecology, Sakarya Research and Education Hospital, Sakarya, Turkey.
Serkan
S
Kumbasar
Department of Obstetrics and Gynecology, Istanbul Suleymaniye Research and Education Hospital, Istanbul, Turkey.
Özer
Ö
Gül
Department of Obstetrics and Gynecology, Istanbul Aydın University, İstanbul, Turkey.
Aytek
A
Şık
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D010064:Embryo Implantation / Q000187:drug effects; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D007247:Infertility, Female / Q000628:therapy*; D010894:Piroxicam / Q000008:administration & dosage*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D007213:Indomethacin
embryo transfer; implantation failure; in vitro fertilization; indomethacin; piroxicam