The Relationship Between Coronary Artery Disease and Genetic Polymorphisms of Melanoma Inhibitory Activity 3.
BACKGROUND
Melanoma Inhibitory Activity 3 regulates the plasma level of LDL cholesterol. The c.3169 + 315G > A single-nucleotide polymorphism of the MIA3 gene has been reported to be associated with serum coronary artery disease (CAD). However, there have been no studies analyzing the association of this polymorphism with CAD in Iranian individuals with CAD.


OBJECTIVE
Therefore, in the present study we have investigated the potential protective effect of the rs3008621 MIA3 polymorphism in 188 subjects with and without CAD.


METHODS
Genotyping of the MIA3 gene was undertaken using TaqMan real-time PCR in all subjects. Anthropometric and biochemical features, including HDL, LDL, and TG were assessed in all subjects.


RESULTS
The CAD patients had significantly (P < 0.05) higher BMI and significantly higher levels of TG, LDL, SBP, and DBP, while the level of HDL was lower compared to that of the control group. the MIA3 gene polymorphism was not associated with CAD in our population sample.


CONCLUSIONS
The MIA3 polymorphism is unlikely to play an important role in CAD in the Iranian population. However, further studies are needed in a larger population to confirm this.
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
Hooshang
H
Zaimkohan
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
Mohammad
M
Keramatipour
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Reza
SR
Mirhafez
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
Javad
J
Tavakkoly-Bazzaz
Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
Azadeh
A
Tahooni
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Mohammad
M
Piryaei
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid
M
Ghayour-Mobarhan
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Seyed Mohammad Hossein
SM
Ghaderian
Coronary Artery Disease; Polymorphism; Proprotein Convertase Subtilisin/Kexin Type 9