Role of Leukocyte-Platelet-Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction.
ObjectiveAdvancements in endoscopic endonasal approaches have increased the extent and complexity of skull base resections, in turn demanding the development of novel techniques for skull base defect reconstruction. The objective of this pilot study was to investigate the effect of leukocyte-platelet-rich fibrin (L-PRF) on the postoperative healing after endoscopic skull base surgery.MethodsBetween January and May of 2015, 47 patients underwent endoscopic endonasal resection of sellar, parasellar, and suprasellar lesions with the application of L-PRF membranes during the skull base reconstruction at two surgical centers. Early postoperative records were retrospectively reviewed.ResultsWe found that 21 days following the surgery, 17/41 patients (42%) demonstrated improvement in the crusting score as compared with their 7 day postoperative examination. Ten of these patients (23%) showed no crusting. Fourteen (34%) patients had no change in the crusting score. Six patient records were incomplete. A total of 4/47 cases (8.5%) had postoperative cerebrospinal fluid leak requiring surgical repair.ConclusionThis study demonstrates the potential utility of L-PRF membranes for skull base defect reconstruction. Future studies will be conducted to better assess the role of L-PRF in endoscopic skull base surgery.
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Liuba
L
Soldatova
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Raewyn G
RG
Campbell
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Ahmad H
AH
Elkhatib
Department of Otolaryngology - Head & Neck Surgery, Universidad de Concepción, Concepcion, Chile.
Thomas W
TW
Schmidt
Graduate School of Periodontics and Implant Dentistry, Research Center for Regenerative Medicine and Tissue Engineering, University of the Andes-Chile, Concepcion, Chile.
Nelson R
NR
Pinto
Department of Neurosurgery, Universidad de Concepción, Concepcion, Chile.
Jaime M
JM
Pinto
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States; Department of Neurologic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Daniel M
DM
Prevedello
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Leo F
LF
Ditzel Filho
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States; Department of Neurologic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Bradley A
BA
Otto
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States; Department of Neurologic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Ricardo L
RL
Carrau
endoscopic endonasal approach; endoscopic skull base surgery; leukocyte–platelet-rich fibrin; skull base defect reconstruction