Versicoamides F-H, Prenylated Indole Alkaloids from Aspergillus tennesseensis.
Three highly modified indole alkaloids, versicoamides F-H (1-3), together with seven known alkaloids (4-10) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configurations of 1 and 2 were assigned by single-crystal X-ray diffraction experiments. Compounds 1 and 2 showed weak antiproliferative activity against the H460 cell line. Compounds 1-3 represent a new class of natural product hybrids with new chemical skeletons.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Li
L
Liu
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.
Long
L
Wang
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Li
L
Bao
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Jinwei
J
Ren
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|International College, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Buddha
B
Bahadur Basnet
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Ruixing
R
Liu
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Luwei
L
He
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.
Junjie
J
Han
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Wen-Bing
WB
Yin
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Hongwei
0000-0001-6471-131X
H
Liu
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D054876:Prenylation; D015398:Signal Transduction
D000970:Antineoplastic Agents; D026121:Indole Alkaloids