Improvement in Quality of Life and Hemodynamics in Chronic Thromboembolic Pulmonary Hypertension Treated With Balloon Pulmonary Angioplasty.
The effect of balloon pulmonary angioplasty (BPA) on improvement in functional and hemodynamic parameters in chronic thromboembolic pulmonary hypertension (CTEPH) is known, but the quality of life (QoL) of patients treated with BPA has never been studied before.



Twenty-five patients with inoperable or persistent CTEPH were enrolled in the study and filled out the 36-item Short Form (SF-36v2) questionnaire twice: prior to commencement of BPA treatment and after ≥3 BPA sessions. In addition WHO functional class, distance on the 6-min walk test (6MWT) and hemodynamic parameters such as right atrial pressure (RAP), mean pulmonary artery pressure (mPAP), cardiac index (CI) and pulmonary vascular resistance (PVR) were assessed. QoL improved significantly in all domains, except for physical pain. Improvement in RAP (10.5±3.4 vs. 6.2±2.2 mmHg; P<0.05), mPAP (51.7±10.6 vs. 35.0±9.1 mmHg; P<0.05), CI (2.2±0.5 vs. 2.5±0.4 L/min·m2; P=0.04), PVR (10.4±3.9 vs. 5.5±2.2 Wood units; P<0.05), functional class (96% vs. 20% in WHO class III and IV, P<0.05) and improvement in 6MWT distance (323±135 vs. 410±109 m; P<0.05) was observed. The only significant correlation was between the mental component summary score of QoL after completion of treatment and percentage improvement in the 6MWT (-0.404, P<0.05).



Alongside improvement in functional and hemodynamic parameters, BPA also provides significant improvement in QoL.
Department of Pulmonary Circulation and Thromboembolic Diseases, European Health Centre Otwock, Medical Centre for Postgraduate Education.
Szymon
S
Darocha
Radosław
R
Pietura
Arkadiusz
A
Pietrasik
Justyna
J
Norwa
Anna
A
Dobosiewicz
Michał
M
Piłka
Michał
M
Florczyk
Andrzej
A
Biederman
Adam
A
Torbicki
Marcin
M
Kurzyna
D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods / Q000592:standards*; D002908:Chronic Disease; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000628:therapy*; D011788:Quality of Life; D020127:Recovery of Function; D011795:Surveys and Questionnaires