Copper-Catalyzed P-H Insertions of α-Imino Carbenes for the Preparation of 3-Phosphinoylindoles.
A highly efficient P-H insertion of α-imino copper carbene into H-phosphine oxides, leading to 3-phosphinoylindoles with a broad substrate diversity and good chemoselectivity, is established. This methodology provides a rapid and efficient approach for the C (sp2)-P bond formation via the P-H insertion strategy. The stereoselective P-H insertion of α-imino copper carbene represents a unique example of asymmetric P-H insertion, affording P-stereogenic 3-phosphinoylindoles with high stereoselectivities.
School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, P. R. China.
Lisheng
L
Wang
School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, P. R. China.
Yi
Y
Wu
School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, P. R. China.
Yang
Y
Liu
School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, P. R. China.
Hua
H
Yang
School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, P. R. China.
Xu
X
Liu
School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, P. R. China.
Jianyi
J
Wang
Department of Chemistry, Stanford University , Stanford, California 94305-5580, United States.
Xiaoxun
X
Li
School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, P. R. China.
Jun
0000-0002-5542-7592
J
Jiang