Inflammation and Peritoneal Dialysis.
Inflammation is one of the well-recognized nontraditional risk factors that contributes to the excessive cardiovascular mortality in peritoneal dialysis (PD) patients. Serum C-reactive protein and interleukin-6 levels are common surrogate markers used to measure inflammatory burden and predict adverse clinical outcomes in PD patients. Causes of inflammation are complex and can be categorized into factors related to a decrease in renal function and factors related to dialysis. They interact with each other and finally result in systemic and intraperitoneal inflammation. This review discusses the various causes and clinical implications of inflammation in PD patients. More importantly, potential therapeutic options that target the underlying pathogenic mechanisms are explored.
Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address: philipli@cuhk.edu.hk.
Philip Kam-Tao
PK
Li
Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Jack Kit-Chung
JK
Ng
Division of Nephrology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Christopher William
CW
Mcintyre
D054392:Adipokines / Q000276:immunology*; D002097:C-Reactive Protein / Q000276:immunology; D002318:Cardiovascular Diseases / Q000276:immunology* / Q000401:mortality; D055499:Catheter-Related Infections / Q000276:immunology*; D002408:Catheters, Indwelling; D019446:Endotoxemia / Q000276:immunology; D005547:Foreign Bodies / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D015850:Interleukin-6 / Q000276:immunology; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000628:therapy*; D018384:Oxidative Stress / Q000276:immunology*; D010530:Peritoneal Dialysis; D010538:Peritonitis / Q000276:immunology*; D011379:Prognosis
D054392:Adipokines; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein
Inflammation; adipokines; cardiovascular; endotoxin; peritoneal dialysis