Nickel(II) diacetyl monoxime-2-pyridyl hydrazone complex can inhibit Ehrlich solid tumor growth in mice: A potential new antitumor drug.
The chief chemotherapeutic drug, cisplatin had common bad effects such as nephrotoxicity, ototoxicity and bone marrow depression. This led us to develop a new potential anticancer drug based on nickel metal ion that may be less toxic. Nickel(II) diacetyl monoxime-2-pyridyl hydrazone complex cytoprotective effect, superoxide dismutase (SOD)-like activity and anticancer activities were studied. In vitro, the complex showed SOD-like activity of 86.62%. It was capable to kill 90.2% of Ehrlich ascites carcinoma (EAC) cells and to protect 92.48% of human RBCs. In vivo, the complex lowered the tumor burden markedly in a concentration-dependent manner. Noticeably, solid tumor growth was suppressed; tumor volume and weight were reduced and mice life span was lengthened. The hematological indices were improved, catalase activity was re-elevated and malondialdehyde (MDA) level was reversed towards normal. Nucleic acids, cholesterol, triglycerides, liver enzymes, urea and creatinine contents were reduced to near normal ranges. Glutathione (GSH), SOD, albumin and total protein levels were increased. In conclusion, our results revealed that the complex has the ability to suppress Ehrlich solid tumor growth in mice with minimal side effects. This may possibly via its redox activity. Surprisingly, nickel complex antitumor activities were more potent than those of cisplatin.
Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt. Electronic address: entsarsaad@gmail.com.
Entsar A
EA
Saad
Chemistry Department, Industrial Education College, Beni-Suef University, Beni-Suef, Egypt.
Mohamed M
MM
Hassanien
Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt.
Faten W
FW
El-Lban
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis; D017209:Apoptosis / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003931:Diacetyl / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005240:Feasibility Studies; D005260:Female; D006835:Hydrazones / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D009532:Nickel / Q000008:administration & dosage* / Q000737:chemistry
D000970:Antineoplastic Agents; D006835:Hydrazones; C004717:diacetylmonoxime; D009532:Nickel; D003931:Diacetyl
Antitumor; Cisplatin; Complex; Cytotoxicity; Nickel chloride (PubChem CID: 24385); Nickel(II) diacetyl monoxime-2-pyridyl hydrazone complex (PubChem CID: not found); Nucleic acids; Redox activity; diacetyl monoxime-2-pyridyl hydrazone (PubChem CID: not found)