Prevalence of and Risk Factors for Oral Human Papillomavirus Infection With Multiple Genotypes in the United States.
This study investigated the prevalence of and risk factors for oral human papillomavirus (HPV) infection with multiple genotypes in the United States.



Data were from the nationally representative 2009-2012 National Health and Nutrition Examination Survey. This analysis comprised 9257 participants for whom data on oral HPV (37 genotypes) and associated risk factors were available.



The weighted prevalence of multitype (2-6 types) oral HPV infection was 1.5% (2.5% for men, 0.4% for women) in the whole sample and 19.7% (22.0% for men, 12.1% for women) in those who had any type of oral HPV positivity. Most multitype oral HPV cases (83.8%) harbored one or more oncogenic types. In the adjusted multinominal logistic regression model, being male (relative risk ratio [RRR] = 3.69; 95% confidence interval [CI], 1.57-8.65), being a current cigarette smoker (RRR = 2.57; 95% CI, 1.23-5.36), and having a new sex partner in the past year (RRR = 2.10; 95% CI, 1.03-4.28) were associated with an increased risk of multitype oral HPV infection over single-type HPV infection.



Men, smokers, and those who had new sexual partners were at a significantly higher risk for multitype oral HPV infection.
From the *Department of Family and Preventative Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK; †Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX; ‡Department of Epidemiology and Biostatistics, College of Public Health, The University of Georgia, Athens, GA; § Division of Quantitative Sciences, Department of Biostatistics, and ¶ Division of Surgery, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
Thanh Cong
TC
Bui
Ly Thi-Hai
LT
Tran
Thuy Nhu
TN
Thai
Sanjay S
SS
Shete
Damon J
DJ
Vidrine
Erich M
EM
Sturgis
D000293:Adolescent; D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000453:epidemiology* / Q000821:virology; D009749:Nutrition Surveys; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult