Parkinson's disease as a multisystem disorder.
This article summarises the noteworthy contribution of Professor Jellinger to the understanding of Parkinson's disease (PD) as a disease affecting multiple body- and neurotransmitter-systems. Phosphorylated alpha-synuclein and the formation of Lewy pathology as neuropathological hallmarks of PD seem to spread from the enteric nervous system and the olfactory bulb in a rostrocranial direction to the CNS. Subsequently, a progressive degeneration of the dopaminergic-nigrostriatal system and widespread extranigral pathology affecting different anatomical structures and neurotransmitters are induced causing the various non-motor and motor symptoms of PD.
Department of Neurology, Technical University Dresden, Fetscherstraße 74, 01307, Dresden, Germany. lisa.klingelhoefer@uniklinikum-dresden.de.
Lisa
L
Klingelhoefer
Department of Neurology, Technical University Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
H
H
Reichmann
D000818:Animals; D001921:Brain / Q000503:physiopathology; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology*
Alpha-synuclein; NMS; Non-motor symptoms; PD; Parkinson’s disease; Proteinopathy