Protective Effect of Ellagic Acid on Paraquat-induced Kidney Hazards in Rats.
BACKGROUND
Paraquat is a commonly used highly toxic herbicide. Despite many studies on detoxification of paraquat, an efficient and safe antidote has not been introduced for toxic cases in human being. The aim of this study was to investigate the effect of ellagic acid (EA) on paraquat-induced kidney hazards in rats.


METHODS
Sixty rats were randomly assigned as controls and 5 treatment groups (n = 10 each) receiving EA only, paraquat at doses of 15 mg/kg and 45 mg/kg, and paraquat at the same doses plus EA. Paraquat was intraperitoneally injected and the EA was orally given. Kidney tissues were stained with hematoxylin-eosin for histopathologic investigation.


RESULTS
Pathologic scoring showed that paraquat at the higher dose was associated with higher scores than the in the controls, EA group, and the high-dose paraquat group with EA treatment (P < .001 for all comparisons).  It was noted that paraquat caused a serious damage in the kidney and the EA treatment significantly reduced the extent of the damage.


CONCLUSIONS
This study showed the protective effects of EA against paraquat-induced nephrotoxicity histologically. Ellagic acid provided significant improvement in glomerular and tubular structure.
Department of Pediatrics, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey. drsilfeler@gmail.com.
Ibrahim
I
Silfeler
Harun
H
Alp
Bayram Ali
BA
Dorum
Emel
E
Nacar
Selda
S
Arslan
Veli
V
Uygur
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004610:Ellagic Acid / Q000494:pharmacology*; D006540:Herbicides / Q000494:pharmacology / Q000633:toxicity; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D023421:Models, Animal; D010269:Paraquat / Q000494:pharmacology / Q000633:toxicity; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D016896:Treatment Outcome
D006540:Herbicides; D020011:Protective Agents; D004610:Ellagic Acid; D010269:Paraquat