Mean Platelet Volume Could Reflect Disease Activity of Adult Patients With Systemic Lupus Erythematosus.
BACKGROUND
In recent years, research regarding mean platelet volume (MPV) has been expanded to numerous diseases. The aim of the present study was to assess whether MPV could reflect disease activity of adult patients with systemic lupus erythematosus (SLE).


METHODS
A total of 128 adult patients with SLE were enrolled in the present study and allocated into two subgroups (99 with active phase and 29 with inactive phase) according to SLE disease activity index (SLEDAI). Demographic data, MPV, complement 3 (C3), and complement 4 (C4) were recorded. Independent sample t-test was used for comparison of quantitative variables between the active and inactive groups. Pearson's correlation test was used to evaluate the correlation between the above laboratory indices and the SLEDAI score.


RESULTS
The mean MPV level in active patients was significantly higher than inactive subjects (8.3 ± 1.3 vs. 7.7 ± 0.7, p < 0.001). The correlation between MPV level and SLEDAI score was moderate (r = 0.520, p < 0.001).


CONCLUSIONS
MPV might be a promising marker to reflect disease activity of adult patients with SLE.
Mingjian
M
Bai
Lingsheng
L
Xing
Jing
J
Feng
Chanjuan
C
Cui
Lei
L
Huang
Guowei
G
Liang
D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000503:physiopathology; D008297:Male; D063847:Mean Platelet Volume; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D015415:Biomarkers; D003176:Complement C3; D003181:Complement C4