Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo.
In using nanomaterials for advanced photodynamic therapy, it is important to improve surface modification to increase stability, minimize non-specific loss of drugs in blood circulation, enhance the photostability of photosensitizers, and achieve highly efficient intracellular uptake. In this report, we for the first time covalently conjugate photosensitizer Chlorin e6 (Ce6) to polyethylene glycol modified layered double hydroxides and produce hybrid nanoflakes. These nanoflakes display many superior characteristics and lead to excellent in vivo photodynamic therapeutic efficiency and safety profiles.
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics (SIIA), Chengdu University, Chengdu, Sichuan, P. R. China and Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, P. R. China. apwjzh@cityu.edu.hk.
Li
http://orcid.org/0000-0001-7184-9720
L
Yan
Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, P. R. China.
Zhigang
Z
Wang
Institute for Bioengineering, School of Engineering, The University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JL, UK. xianfeng.chen@oxon.org.
Xianfeng
http://orcid.org/0000-0002-3189-2756
X
Chen
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics (SIIA), Chengdu University, Chengdu, Sichuan, P. R. China.
Xiao-Jun
XJ
Gou
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, P. R. China. apwjzh@cityu.edu.hk.
Zhenyu
Z
Zhang
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, P. R. China. apwjzh@cityu.edu.hk.
Xiaoyue
X
Zhu
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, P. R. China. apwjzh@cityu.edu.hk.
Minhuan
M
Lan
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, P. R. China. apwjzh@cityu.edu.hk.
Wei
W
Chen
Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, P. R. China.
Guangyu
G
Zhu
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, P. R. China. apwjzh@cityu.edu.hk.
Wenjun
W
Zhang