Transiently thermoresponsive polymers and their applications in biomedicine.
The focus of this review is on the class of transiently thermoresponsive polymers. These polymers are thermoresponsive, but gradually lose this property upon chemical transformation - often a hydrolysis reaction - in the polymer side chain or backbone. An overview of the different approaches used for the design of these polymers along with their physicochemical properties is given. Their amphiphilic properties and degradability into fully soluble compounds make this class of responsive polymers attractive for drug delivery and tissue engineering applications. Examples of these are also provided in this review.
Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. br.degeest@ugent.be.
Nane
N
Vanparijs
Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. br.degeest@ugent.be.
Lutz
L
Nuhn
Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. br.degeest@ugent.be.
Bruno G
http://orcid.org/0000-0001-9826-6170
BG
De Geest
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006868:Hydrolysis; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D044367:Phase Transition; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D011108:Polymers