Serum Levels of Cardiac Troponin I in Asphyxiated Neonates Predict Mortality.
BACKGROUND
Cardiac troponin I (cTnI) is a well-established marker for detecting myocardial ischemic damage in neonates with hypoxic-ischemic encephalopathy. However, the predictive value of cTnI in assessing mortality in neonatal asphyxia remains obscure. This retrospective study aims to analyze the relationship between cTnI levels in blood serum with gestational age, birth weight, gender, delivery type, electrocardiography, echocardiography, Apgar scores, length of hospital stay, and mortality in asphyxiated neonates.


METHODS
This study included 164 full-term neonates with evidence of asphyxia. Myocardial markers, electrocardiography, and echocardiography were assessed in the first 24 hours after birth in neonates with asphyxia. The length of hospital stay and short-term outcome were assessed.


RESULTS
There were no statistically significant correlations found between cTnI concentrations and traditional markers of asphyxia, length of hospitalization or mode of delivery. However, high cTnI levels were significant predictors of mortality in neonates with birth asphyxia.


CONCLUSIONS
This study highlights the significance of monitoring cardiac injury in asphyxiated neonates. Serum cTnI levels measured at 24 hours after birth are likely to have significant predictive value for assessing mortality in neonates with birth asphyxia.
Wen-Jie
WJ
Zhou
Fan
F
Yu
Jing
J
Shi
Hui
H
Yang
Sheng-Jie
SJ
Zou
Yong-Mei
YM
Jiang
D001238:Asphyxia Neonatorum / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D012189:Retrospective Studies; D019210:Troponin I / Q000097:blood*
D019210:Troponin I