Meta-analysis of functional magnetic resonance imaging studies of timing and cognitive control in schizophrenia and bipolar disorder: Evidence of a primary time deficit.
Schizophrenia (SZ) and Bipolar Disorder (BD) are associated with deficits in both timing and cognitive control functions. However, the underlying neurological dysfunctions remain poorly understood. The main goal of this study was to identify brain structures activated both by increases in cognitive activity and during timing tasks in patients with SZ and BD relative to controls. We conducted two signed differential mapping (SDM) meta-analyses of functional magnetic resonance imaging studies assessing the brain response to increasing levels of cognitive difficulty: one concerned SZ, and the other BD patients. We conducted a similar SDM meta-analysis on neuroimaging of timing in SZ (no studies in BD could be included). Finally, we carried out a multimodal meta-analysis to identify common brain regions in the findings of the two previous meta-analyses. We found that SZ patients showed hypoactivation in timing-related cortical-subcortical areas. The dysfunction observed during timing partially coincided with deficits for cognitive control functions. We hypothesize that a dysfunctional temporal/cognitive control network underlies the persistent cognitive impairment observed in SZ.
Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, Spain. Electronic address: ilalustiza@unav.es.
Irene
I
Alústiza
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden; FIDMAG Germanes Hospitalaries, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
Joaquim
J
Radua
Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, Spain.
Marta
M
Pla
Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, Spain.
Raquel
R
Martin
Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, Spain.
Felipe
F
Ortuño
D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology; D056344:Executive Function / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013998:Time Perception / Q000502:physiology*
Bipolar disorder; Cognitive control; Functional neuroimaging; SDM-meta-analysis; Schizophrenia; Timing