Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative.
Higher body mass index (BMI) measured before endometrial cancer diagnosis has been associated with greater risk of developing endometrial cancer and higher mortality, but the association between BMI measured after diagnosis and mortality risk is unclear. We identified 467 women (91 deaths) in the Women's Health Initiative (WHI) with information on BMI measured after diagnosis and used Cox proportional hazards regression to generate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality. Comparing BMI 35+ with <25 kg/m2, we observed no association with all-cause mortality (HR = 1.02, 95% CI 0.55-1.91). Our study does not support the hypothesis that higher BMI after endometrial cancer diagnosis is associated with poorer survival.
George Washington University Milken Institute School of Public Health, Washington, DC, United States of America.
Hannah
H
Arem
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Ruth M
RM
Pfeiffer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Steven C
SC
Moore
Yale School of Public Health; Yale Cancer Center, New Haven, CT, United States of America.
Melinda L
ML
Irwin
School of Public Health and Health Professions, Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, United States of America.
Michael J
MJ
LaMonte
UW Madison Department of Obstetrics and Gynecology, Madison, WI, United States of America.
Gloria E
GE
Sarto
Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, United States of America.
Rami
R
Nassir
Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, IN, United States of America.
Juhua
J
Luo
Los Angeles Biomedical Research Institute at the Harbor-UCLA Medical Center, Torrance, CA, United States of America.
Rowan T
RT
Chlebowski
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Louise A
LA
Brinton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.
Charles E
CE
Matthews
D000368:Aged; D015992:Body Mass Index; D016889:Endometrial Neoplasms / Q000150:complications / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D006801:Humans; D009765:Obesity / Q000401:mortality; D050177:Overweight / Q000401:mortality; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis