Dynamic hub load predicts cognitive decline after resective neurosurgery.
Resective neurosurgery carries the risk of postoperative cognitive deterioration. The concept of 'hub (over)load', caused by (over)use of the most important brain regions, has been theoretically postulated in relation to symptomatology and neurological disease course, but lacks experimental confirmation. We investigated functional hub load and postsurgical cognitive deterioration in patients undergoing lesion resection. Patients (n = 28) underwent resting-state magnetoencephalography and neuropsychological assessments preoperatively and 1-year after lesion resection. We calculated stationary hub load score (SHub) indicating to what extent brain regions linked different subsystems; high SHub indicates larger processing pressure on hub regions. Dynamic hub load score (DHub) assessed its variability over time; low values, particularly in combination with high SHub values, indicate increased load, because of consistently high usage of hub regions. Hypothetically, increased SHub and decreased DHub relate to hub overload and thus poorer/deteriorating cognition. Between time points, deteriorating verbal memory performance correlated with decreasing upper alpha DHub. Moreover, preoperatively low DHub values accurately predicted declining verbal memory performance. In summary, dynamic hub load relates to cognitive functioning in patients undergoing lesion resection: postoperative cognitive decline can be tracked and even predicted using dynamic hub load, suggesting it may be used as a prognostic marker for tailored treatment planning.
Department of Anatomy &Neurosciences, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Ellen W S
EW
Carbo
Department of Clinical Neurophysiology and MEG Center, VU University Medical Center, Amsterdam, The Netherlands.
Arjan
A
Hillebrand
Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.|Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Edwin
E
van Dellen
Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.|Sir Peter Mansfield Imaging Centre, School of Physics, University of Nottingham, Nottingham, UK.
Prejaas
P
Tewarie
Department of Neurosurgery, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.|VUmc CCA Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
Philip C
PC
de Witt Hamer
Department of Neurosurgery, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
Johannes C
JC
Baayen
VUmc CCA Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.|Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands.
Martin
M
Klein
Department of Anatomy &Neurosciences, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Jeroen J G
JJ
Geurts
Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.|VUmc CCA Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
Jaap C
JC
Reijneveld
Department of Clinical Neurophysiology and MEG Center, VU University Medical Center, Amsterdam, The Netherlands.
Cornelis J
CJ
Stam
Department of Anatomy &Neurosciences, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands.|VUmc CCA Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.|Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Linda
L
Douw
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D063132:Connectome; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D006392:Hemangioma, Cavernous / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D060787:Neoplasm Grading; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D009483:Neuropsychological Tests; D009493:Neurosurgery / Q000379:methods; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D011379:Prognosis; D014402:Tuberous Sclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery