Anterior Segment Findings in Women with Polycystic Ovary Syndrome.
OBJECTIVE
This study aimed to investigate the anterior segment in women with polycystic ovary syndrome (PCOS) and to compare them with those of healthy reproductive-age female volunteers.


METHODS
The study included 50 right eyes of 50 women with PCOS (group 1) and 50 right eyes of 50 healthy women (group 2). Intraocular pressure, Schirmer's test, tear film break-up time and central corneal thickness were evaluated in all subjects. Correlations between serum hormone (estradiol and testosterone) levels and observed findings were also investigated.


RESULTS
Mean central corneal thickness values were significantly higher in the PCOS group (p=0.001). The mean intraocular pressures values were similar between the two groups (p=0.560). Schirmer's test results and tear film break-up time values were significantly lower in the PCOS group (p=0.001 and p=0.001 respectively). Serum estradiol levels were moderately positively correlated with mean central corneal thickness (r=0.552), weakly positively correlated with intraocular pressure (r=0.351) and weakly negatively correlated with tear film break-up time (r=-0.393). Serum free testosterone levels were weakly correlated with intraocular pressure (r=0.342) and central corneal thickness (r=0.303), and showed weak negative correlations with Schirmer's test results (r=-0.562) and tear film break-up time (r=-0.502).


CONCLUSIONS
PCOS leads to physiological and structural changes in the eye. Dry eye symptoms were more severe and central corneal thickness measurements were greater in patients with PCOS. Those are correlated serum testosterone and estradiol levels.
Tepecik Training and Research Hospital, Ophthalmology Clinic, İzmir, Turkey.
Seda
S
Karaca Adıyeke
Aliağa State Hospital, Gynecology and Obstetrics Clinic, İzmir, Turkey.
Ibrahim
I
Karaca
Tepecik Training and Research Hospital, Gynecology and Obstetrics Clinic, İzmir, Turkey.
Suna
S
Yıldırım
Bergama State Hospital, Gynecology and Obstetrics Clinic, İzmir, Turkey.
Mehmet
M
Adıyeke
Tepecik Training and Research Hospital, Gynecology and Obstetrics Clinic, İzmir, Turkey.
İbrahim
İ
Uyar
Tepecik Training and Research Hospital, Ophthalmology Clinic, İzmir, Turkey.
Gamze
G
Türe
Dry eye; Polycystic ovary syndrome; corneal thickness