Continuous Flow α-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis.
The first direct α-arylation of aldehyde-derived N,N-dialkylhydrazones with electron deficient aryl and heteroaryl cyanides under visible-light photoredox catalysis has been developed. Structurally complex α,α'-diaryl-N,N-cycloalkylhydrazones were obtained in moderate yields by repetition of the direct arylation protocol. A continuous-flow procedure for the preparation of α-aryl-N,N-dialkylhydrazones on a multigram scale has also been established.
Neuroscience Medicinal Chemistry, Janssen Research & Development , Jarama 75A, 45007 Toledo, Spain.
Juan A
JA
Vega
Neuroscience Medicinal Chemistry, Janssen Research & Development , Jarama 75A, 45007 Toledo, Spain.
José Manuel
JM
Alonso
Neuroscience Medicinal Chemistry, Janssen Research & Development , Jarama 75A, 45007 Toledo, Spain.
Gabriela
G
Méndez
Neuroscience Medicinal Chemistry, Janssen Research & Development , Jarama 75A, 45007 Toledo, Spain.
Myriam
M
Ciordia
Neuroscience Medicinal Chemistry, Janssen Research & Development , Jarama 75A, 45007 Toledo, Spain.
Francisca
F
Delgado
Neuroscience Medicinal Chemistry, Janssen Research & Development , Jarama 75A, 45007 Toledo, Spain.
Andrés A
0000-0002-4225-758X
AA
Trabanco