Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly.
Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.
Department of Cellular and Molecular Medicine, Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK. Electronic address: w.wood@bristol.ac.uk.
Will
W
Wood
Departments of Biochemistry and Physiology, Pharmacology and Neuroscience, Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Lee Kong Chiang School of Medicine, Nanyang Technological University, Singapore 636921, Singapore. Electronic address: paul.martin@bristol.ac.uk.
Paul
P
Martin
D000818:Animals; D019521:Body Patterning; D019070:Cell Lineage; D004194:Disease; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
Drosophila; apoptosis; development; disease; immunity; inflammation; macrophage; migration; wound