Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review.
There is scarcity of information on primary cutaneous low-grade neoplasms commonly known as carcinoid tumors, owing to their rarity. The authors present 3 cases that were named "low-grade neuroendocrine carcinoma of the skin" (LGNECS). These occurred in the dermis and subcutis of the anterior chest or the inguinal region in the elderly. Histologically, the tumors showed infiltrating proliferation of nests of various sizes, with low-grade neuroendocrine cytologic features but without mucin production. All cases exhibited varying degrees of intraductal tumor components. On immunohistochemical examination, these tumors expressed estrogen receptor alpha, progesterone receptor, androgen receptor, gross cystic disease fluid protein 15, mammaglobin, and GATA3 as well as neuroendocrine markers. Although a literature review revealed 8 additional possible cases with no evidence of other diseases, it was difficult to determine if these were true cases of LGNECS, because of the limited information available. Based on its characteristic histologic features and immunoprofile, it can be proposed designating LGNECS as a distinct entity among cutaneous neuroendocrine tumors. Otherwise, such tumors could be misdiagnosed as mammary carcinomas (particularly when involving the skin of the breast) or as metastatic visceral neuroendocrine tumors of the skin.
*Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan; †Sapporo Dermatopathology Institute, Sapporo, Japan; ‡Department of Plastic and Reconstructive Surgery, Saitama Medical University, Saitama, Japan; §Departments of Dermatology, and ¶Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan; and ‖Department of Breast Surgery, Kainan Hospital, Yatomi, Japan.
Keisuke
K
Goto
Takashi
T
Anan
Takashi
T
Nakatsuka
Yo
Y
Kaku
Takaki
T
Sakurai
Takaya
T
Fukumoto
Tetsunori
T
Kimura
Arihiro
A
Shibata
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002276:Carcinoid Tumor / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor