Biology of the Microbiome 1: Interactions with the Host Immune Response.
The intestinal immune system is intimately connected with the vast diversity of microbes present within the gut and the diversity of food components that are consumed daily. The discovery of novel molecular mechanisms, which mediate host-microbe-nutrient communication, have highlighted the important roles played by microbes and dietary factors in influencing mucosal immune responses. Dendritic cells, epithelial cells, innate lymphoid cells, T regulatory cells, effector lymphocytes, natural killer T cells, and B cells can all be influenced by the microbiome. Many of the mechanisms being described are bacterial strain or metabolite specific.
Department of Clinical Immunology, Wroclaw Medical University, Chalubinskiego 5, Wroclaw 50-368, Poland.
Sylwia
S
Smolinska
Alimentary Health Pharma Davos, Obere Strasse 22, Davos Platz 7270, Switzerland.
David
D
Groeger
Molecular Immunology, Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz 7270, Switzerland. Electronic address: liam.omahony@siaf.uzh.ch.
Liam
L
O'Mahony
D056704:Adaptive Immunity; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001419:Bacteria / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D005232:Fatty Acids, Volatile / Q000276:immunology; D000069196:Gastrointestinal Microbiome / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007223:Infant; D007231:Infant, Newborn; D008264:Macrophages / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D005232:Fatty Acids, Volatile
Adaptive immune system; Histamine; Innate immune system; Microbiome; SCFA