An Isomer-Specific Approach to Endocrine-Disrupting Nonylphenol in Infant Food.
Nonylphenols (NPs) are persistent endocrine disruptors that are priority hazardous substances of the European Union Water Framework Directive. Their presence in the environment has caused growing concern regarding their impact on human health. Recent studies have shown that nonylphenol is ubiquitous in commercially available foodstuffs and is also present in human blood. The isomer distribution of 4-nonylphenol was analyzed by gas chromatography - mass spectrometry in 44 samples of infant food. Our study shows that the distribution of nonylphenol isomers is dependent on the foodstuff analyzed. Although some isomer groups prevail, different distributions are frequent. Variations are even found in the same food group. Nonylphenol is a complex mixture of isomers, and the estrogenic potentials of each of these isomers are very different. Consequently, to determine the potential toxicological impact of NP in food, an isomer-specific approach is necessary.
Institute of Nutritional and Food Sciences, Food Chemistry, Rheinische Friedrich-Wilhelms-Universität Bonn , Endenicher Allee 11-13, D-53115 Bonn, Germany.|Research Centre Jülich, Institute of Bio- and Geosciences (IBG-2) , D-52425 Jülich, Germany.
Klaus
K
Günther
Research Centre Jülich, Institute of Bio- and Geosciences (IBG-2) , D-52425 Jülich, Germany.
Torsten
T
Räcker
Institute of Nutritional and Food Sciences, Food Chemistry, Rheinische Friedrich-Wilhelms-Universität Bonn , Endenicher Allee 11-13, D-53115 Bonn, Germany.
Roswitha
R
Böhme
D052244:Endocrine Disruptors / Q000032:analysis* / Q000737:chemistry; D005260:Female; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D007225:Infant Food / Q000032:analysis*; D041943:Infant Formula / Q000032:analysis / Q000737:chemistry; D007536:Isomerism; D057230:Limit of Detection; D008895:Milk, Human / Q000737:chemistry; D010636:Phenols / Q000032:analysis* / Q000737:chemistry
D052244:Endocrine Disruptors; D010636:Phenols; C025256:nonylphenol
endocrine disruptors; infant food; isomer distribution; isomer-specific; nonylphenol