Sleep habits, academic performance, and the adolescent brain structure.
Here we report the first and most robust evidence about how sleep habits are associated with regional brain grey matter volumes and school grade average in early adolescence. Shorter time in bed during weekdays, and later weekend sleeping hours correlate with smaller brain grey matter volumes in frontal, anterior cingulate, and precuneus cortex regions. Poor school grade average associates with later weekend bedtime and smaller grey matter volumes in medial brain regions. The medial prefrontal - anterior cingulate cortex appears most tightly related to the adolescents' variations in sleep habits, as its volume correlates inversely with both weekend bedtime and wake up time, and also with poor school performance. These findings suggest that sleep habits, notably during the weekends, have an alarming link with both the structure of the adolescent brain and school performance, and thus highlight the need for informed interventions.
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.|National Institute for Health and Welfare, Department of Health, Unit of Mental Health, P.O. Box 30, 00271 Helsinki, Finland.|University of Helsinki and Helsinki University Central Hospital, Department of Psychiatry/Adolescent Psychiatry, P.O. Box 803, 00029 HUS, Helsinki, Finland.
Anna S
AS
Urrila
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.|Department of Psychiatry 91G16, 4 place du Général Leclerc, Orsay Hospital, GH Nord-Essonne, 91400 Orsay, France.
Eric
E
Artiges
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.
Jessica
J
Massicotte
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.
Ruben
R
Miranda
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.
Hélène
H
Vulser
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.
Pauline
P
Bézivin-Frere
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.
Winok
W
Lapidaire
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.
Hervé
H
Lemaître
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.|Adolescent Psychiatry Department, Medical school, FI-33014 Tampere University, Finland.
Jani
J
Penttilä
Department of Psychiatry, Université de Montréal, CHU Ste Justine Hospital, 175 Chemin de la Côte-Sainte-Catherine, Montréal, QC H3T 1C4, Canada.|Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology &Neuroscience, King's College, 16 De Crespigny Park, London SE5 8AF, United Kingdom.
Patricia J
PJ
Conrod
Departments of Psychiatry and Psychology, 6436 UHC, University of Vermont. 1 South Prospect Street, Burlington, VT 05401, USA.
Hugh
H
Garavan
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.|APHP, Adolescent Psychopathology and Medicine department, Maison de Solenn, Cochin Hospital, 97 Bd de Port Royal, 75014 Paris, France.
Marie-Laure
ML
Paillère Martinot
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging &Psychiatry", University Paris Sud - University Paris Saclay, University Paris Descartes, 97 Bd de Port Royal, 75014, Paris, France.|CENIR at ICM institute, Centre de Neuroimagerie de Recherche Bâtiment ICM, 47-83 boulevard de l'Hôpital, 75651 Paris Cedex 13,ss France.
Jean-Luc
JL
Martinot
D000073978:Academic Performance; D000293:Adolescent; D000367:Age Factors; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology / Q000502:physiology; D006184:Habits; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012890:Sleep