[Exposition to total parenteral nutrition increases the risk of catheter-related bloodstream infection].
BACKGROUND
Infectious complications associated to central venous catheter (CVC) increase morbidity, mortality and costs. Total parenteral nutrition (TPN) is one of the risk factors described for catheter-related bloodstream infection (CR-BSI). The aim of this study was explore if TPN and time of exposition, are risk factors for CR-BSI among patient exposed to this therapy.


METHODS
Cohort study of patients with CVC exposed and not exposed to TPN with calculation of the relative risk (RR) for CR-BSI and percentage of CR-BSI according to different times of exposition to TPN. Study encompassed years 2010-2015 and only adult patients were included.


RESULTS
During the study period 51 events of CR-BSI were identified, with 27 occurring among those exposed to TPN and 24 among those not exposed. CR-BSI incidence rate was 6.3 in the group with TPN and 1.2 in those without this therapy (RR 5.4; IC 95 3.6-8.2). The percentage of patients with CR-BSI increased in parallel to exposition time (Pearson coefficient +0.91) and the OR increased for expositions ≥ 7 days (OR 2.8; IC 95 1.047.4; p < 0.05).


CONCLUSIONS
Exposition to TPN increases the risk to CR-BSI in adult patients with CVC and this risk raise with exposition time.
Unidad de Infecciones Asociadas a la Atención de Salud, Hospital Militar de Santiago, Chile, tvergara@hms.cl.
Teresa
T
Vergara
Unidad de Infecciones Asociadas a la Atención de Salud, Hospital Militar de Santiago, Chile.
Elena
E
Véliz
Unidad de Infecciones Asociadas a la Atención de Salud, Hospital Militar de Santiago, Chile.
Alberto
A
Fica
D000328:Adult; D000368:Aged; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000209:etiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors