Promoter polymorphism (-590, T/C) of interleukin 4 (IL4) gene is associated with rheumatoid arthritis: An updated meta-analysis.
Rheumatoid arthritis (RA) is a chronic disease. It causes chronic inflammation of the joint. Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA). Especially, it was reported that promoter polymorphism (-590, T/C) ofIL4gene has been associated with susceptibility of RA. The aim of present study was to investigate whether the promoter polymorphism (-590, T/C) ofIL4gene is associated with the susceptibility of RA using meta-analysis. And in order to perform meta-analysis, comprehensive meta analysis program was used. Genetic models (co-dominant, dominant, recessive, and allele) were used to determine odds ratios (ORs), 95% confidence intervals (CIs), andPvalues. Nine case-control studies with case and control design were included in this meta-analysis. Overall, meta-analysis revealed a strong association with susceptibility of RA [OR = 1.303, 95% CI = 1.093-1.554,P= 0.003 in allele model (C vs. T); OR = 1.247, 95% CI = 1.054-1.474,P= 0.010 in dominant model (CC vs. CT + TT); OR = 2.148, 95% CI = 1.263-3.651,P= 0.005 in recessive model (CC + CT vs. TT)]. Our data demonstrated that promoter polymorphism (-590, T/C) ofIL4gene may be contributed to susceptibility of RA. However, more studies with a larger sample size are needed to provide more precise evidence.
Department of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul 05728, Republic of Korea.
Hyun Kyung
HK
Park
Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Su Kang
SK
Kim
National Academy of Agricultural Science, Rural Administration, Jeonju 55365, Republic of Korea.
Hae Yong
HY
Kweon
National Academy of Agricultural Science, Rural Administration, Jeonju 55365, Republic of Korea.
Kwan Gill
KG
Lee
Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Mariadhas Valan
MV
Arasu
Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong 369-873, Republic of Korea.
Young Ock
YO
Kim
Association study; Interleukin 4; Meta-analysis; Polymorphism; Rheumatoid arthritis