Patient-reported control of chronic rhinosinusitis symptoms is positively associated with general health-related quality of life.
OBJECTIVE
In chronic rhinosinusitis (CRS), although patient-reported severity of sinonasal symptoms is significantly associated with diminishment of patients' general health-related quality of life (QOL), it remains unclear whether patient-perceived control of CRS symptomatology is associated with patients' QOL. In this study, we sought to determine the association between patient-perceived control of CRS symptomatology and QOL.


METHODS
Prospective cross-sectional study.


METHODS
Academic, tertiary care centre.


METHODS
A cohort of 166 adults with CRS who were asked to categorise their level of CRS symptom control as "Not at all," "A little," "Somewhat," "Very" and "Completely."


METHODS
General health-related QOL, as reflected by the five-dimensional EuroQol quality of life survey-derived visual analogue scale (EQ5D-VAS) and health utility values (EQ5D-HUV).


RESULTS
We found that higher EQ5D-VAS scores were associated with CRS patients who classified their symptom control as "Very" (adjusted β=15.74, 95% CI: 5.44 to 26.04, P=.003) and "Completely" (adjusted β=14.24, 95% CI: 2.98 to 25.52, P=.014) compared to patients who classified their symptom control as "Not at all." This was also true for higher EQ5D-HUV which was associated with patient-reported CRS symptom control of "A little" (adjusted β=0.10, 95% CI: 0.01 to 0.18, P=.024), "Somewhat" (adjusted β=0.08, 95% CI: 0.00 to 0.17, P=.049), "Very" (adjusted β=0.13, 95% CI: 0.05 to 0.21, P=.002) and "Completely" (adjusted β=0.18, 95% CI: 0.09 to 0.27, P<.001).


CONCLUSIONS
Higher levels of patient-reported CRS symptom control are therefore associated with better QOL. These findings suggest that CRS symptom control should be targeted for improving patients' QOL.
Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.|Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
S T
ST
Gray
Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.|Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
L P
LP
Hoehle
Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.|Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
K M
KM
Phillips
Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.|Division of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
D S
DS
Caradonna
Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.|Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.|Division of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, MA, USA.|Department of Otolaryngology and Communications Enhancement, Boston Children's Hospital, Boston, MA, USA.
A R
http://orcid.org/0000-0001-6331-2325
AR
Sedaghat
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071066:Patient Reported Outcome Measures; D011446:Prospective Studies; D011788:Quality of Life; D012220:Rhinitis / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D012852:Sinusitis / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D063189:Symptom Assessment
nasal polyps; outcomes; rhino-sinusitis and complications