AlncRNA HULC as an effective biomarker for surveillance of the outcome of cancer: A meta-analysis.
OBJECTIVE
High expression of highly upregulated in iver cancer (HULC) has been found associated with increased metastasis and poor prognosis with cancer. This meta-analysis aimed to determine the pooled effect of HULC on metastasis and prognosis of cancers.


METHODS
The studies were accessed using multiple databases. RevMan5.3 and STATA14.0 were used to estimate pooled effects, the heterogeneity among studies, and publication bias for the association of HULC and overall survival (OS).


RESULTS
A total of 9 studies of 966 cancer patients were included. Risk of lymph node metastasis was increased with high versus low HULC expression (pooled odds ratio [OR] = 4.83, 95% confidence interval [CI] 1.59-14.63) as was distant metastasis (pooled OR = 5.44, 95% CI 2.33-12.74). Furthermore, OS time was shortened with high HULC expression (pooled hazard ratio [HR] = 1.48, 95% CI 1.03-2.12), especially in Chinese patients (pooled HR = 2.04, 95% CI 1.55-2.68), and risk of recurrence was increased (pooled OR = 6.68, 95% CI 2.77-16.13).


CONCLUSIONS
HULC might be a potential biomarker for therapy and prognosis surveillance in cancers.
Shenzhen Guangming district center for disease control and prevention, Shenzhen, Guangdong, P.R. China.
Xiaoliang
X
Chen
Longgang district central hospital of Shenzhen, Shenzhen, Guangdong, P.R. China.
Jinbo
J
Lin
Shenzhen Guangming district center for disease control and prevention, Shenzhen, Guangdong, P.R. China.
Yi
Y
Liu
Shenzhen Center for Chronic Disease Prevention, Shenzhen, Guangdong, P.R. China.
Ji
J
Peng
Shenzhen Guangming district center for disease control and prevention, Shenzhen, Guangdong, P.R. China.
Yong
Y
Cao
Shenzhen Guangming district center for disease control and prevention, Shenzhen, Guangdong, P.R. China.
Zhan
Z
Su
Shenzhen Guangming district center for disease control and prevention, Shenzhen, Guangdong, P.R. China.
Tieqiang
T
Wang
Department of Molecular Biology, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, P.R. China.
Jinquan
J
Cheng
School of Medicine, Shenzhen University, Shenzhen, Guangdong, P.R. China.
Dongsheng
D
Hu
D014408:Biomarkers, Tumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D016017:Odds Ratio; D063868:Patient Outcome Assessment; D011379:Prognosis; D016016:Proportional Hazards Models; D017594:Publication Bias; D062085:RNA, Long Noncoding / Q000235:genetics*; D012008:Recurrence
D014408:Biomarkers, Tumor; C574685:HULC long non-coding RNA, human; D062085:RNA, Long Noncoding