Hepatitis C virus and non-Hodgkin's lymphomas: A minireview.
B-cell NHL is strongly associated with HCV that was proved in the last 2 decades. The most common HCV infection related B-NHL subtypes include MZL and DLBCL lymphomas. HCV-positive NHL patients usually present with older age at diagnosis, higher LDH, and more extranodal disease. The standard chemo-immunotherapy tolerance is generally good. Antiviral treatment achieves virological and hematological remission in HCV associated indolent lymphoma. More aggressive lymphoma requires combination of antiviral treatment and chemotherapy. New generation of HCV antiviral drugs is safe and is highly efficacious. Regimens including DAAs appear promising options as they can reduce the HCV-associated NHL incidence by dramatically lowering the HCV chronic carriers.
Medical Oncology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Hussein
H
Khaled
Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Fouad
F
Abu-Taleb
Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Rasha
R
Haggag
Antiviral treatment; Hepatitis C virus; Non-Hodgkin lymphoma; Pathogenesis