Fractal Analysis of Cancer Cell Surface.
Fractal analysis of the cell surface is a rather sensitive method which has been recently introduced to characterize cell progression toward cancer. The surface of fixed and freeze-dried cells is imaged with atomic force microscopy (AFM) modality in ambient conditions. Here we describe the method to perform the fractal analysis specifically developed for the AFM images. Technical details, potential difficulties, points of special attention are described.
Department of Mechanical Engineering, Tufts University, 177 College Ave., Medford, MA, 02155, USA. Igor.sokolov@tufts.edu.|Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA. Igor.sokolov@tufts.edu.|Department of Physics, Tufts University, Medford, MA, 02155, USA. Igor.sokolov@tufts.edu.
Igor
I
Sokolov
Department of Mechanical Engineering, Tufts University, 177 College Ave., Medford, MA, 02155, USA.
Maxim E
ME
Dokukin
D000465:Algorithms; D002462:Cell Membrane / Q000648:ultrastructure*; D017709:Fractals; D006801:Humans; D018625:Microscopy, Atomic Force; D009369:Neoplasms / Q000473:pathology* / Q000648:ultrastructure*; D013499:Surface Properties
Cancer progression; Fractal analysis; Physics of cancer