When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position.
In this issue, Aeschimann et al. (2017) demonstrate that, depending on the target location site (5'UTR or 3'UTR), LIN41 triggers repression of translation or mRNA decay, suggesting that one factor may use two independent pathways of post-transcriptional gene regulation.
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
Jacqelyn M
JM
Hand
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address: arb@stowers.org.
Ariel A
AA
Bazzini
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D014176:Protein Biosynthesis; D020871:RNA Stability; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D012333:RNA, Messenger; D014157:Transcription Factors
RNA-binding protein; early development; gene regulation; mRNA decay; translation repression