Gold nanoparticles ameliorate acetaminophen induced hepato-renal injury in rats.
Valuable effects of gold particles have been reported and used in complementary medicine for decades. The aim of this study was to evaluate the therapeutic efficacy of gold nanoparticles (AuNPs) against acetaminophen (APAP) induced toxicity. Albino rats were administered APAP at a dose of 2g/kg p.o. once only. After 24h of APAP intoxication, animals were treated with three different doses of AuNPs (50μg/kg, 100μg/kg, 150μg/kg) orally or silymarin at a dose of 50mg/kg p.o., once only. Animals of all the groups were sacrificed after 24h of last treatment. APAP administered group showed a significant rise in the AST, ALT, SALP, LDH, cholesterol, bilirubin, albumin, urea and creatinine in serum which indicated the hepato-renal damage. A significantly enhanced LPO and a depleted level of GSH were observed in APAP intoxicated rats. Declined activities of SOD and Catalase, after acetaminophen exposure indicated oxidative stress in liver and kidney. The activities of ATPase and glucose-6-Phosphatase were significantly inhibited after APAP administration. AuNPs treatment reversed all variables significantly towards normal level and was found nontoxic. Thus it is concluded that gold nanoparticles played a beneficial role in reducing acetaminophen induced toxicity and can be used in the development of drug against hepatic as well as renal diseases, after further preclinical and clinical studies.
UNESCO- Trace Element Satellite Center, School of Studies in Zoology, Jiwaji University, Gwalior, (M.P)., India. Electronic address: reshisalim@gmail.com.
Mohd Salim
MS
Reshi
UNESCO- Trace Element Satellite Center, School of Studies in Zoology, Jiwaji University, Gwalior, (M.P)., India.
Sadhana
S
Shrivastava
UNESCO- Trace Element Satellite Center, School of Studies in Zoology, Jiwaji University, Gwalior, (M.P)., India.
Amita
A
Jaswal
UNESCO- Trace Element Satellite Center, School of Studies in Zoology, Jiwaji University, Gwalior, (M.P)., India.
Neelu
N
Sinha
UNESCO- Trace Element Satellite Center, School of Studies in Zoology, Jiwaji University, Gwalior, (M.P)., India.
Chhavi
C
Uthra
UNESCO- Trace Element Satellite Center, School of Studies in Zoology, Jiwaji University, Gwalior, (M.P)., India. Electronic address: profsshukla@gmail.com.
Sangeeta
S
Shukla
D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D005260:Female; D006046:Gold / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D006046:Gold
Acetaminophen; Gold nanoparticles; Kidney; Liver; Toxicity