Differentiating Siblings: The Case of Dopamine and Norepinephrine.
Monitoring dopamine and norepinephrine (or other structurally similar neurotransmitters) in the same brain region necessitates selective sensing. In this Viewpoint, we highlight electrochemical and optical strategies for advancing simultaneous real-time measurements of dopamine and norepinephrine transmission. The potential for DNA aptamers as recognition elements in the context of field-effect transistor sensing for selective and simultaneous neurotransmitter monitoring in vivo is also discussed.
California NanoSystems Institute, University of California, Los Angeles , Los Angeles, California 90095, United States.|Department of Chemistry and Biochemistry, University of California, Los Angeles , Los Angeles, California 90095, United States.
Nako
N
Nakatsuka
California NanoSystems Institute, University of California, Los Angeles , Los Angeles, California 90095, United States.|Department of Chemistry and Biochemistry, University of California, Los Angeles , Los Angeles, California 90095, United States.|Department of Psychiatry and Biobehavioral Health, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.
Anne M
0000-0002-1961-4833
AM
Andrews
D000818:Animals; D015374:Biosensing Techniques; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism*
D004298:Dopamine; D009638:Norepinephrine
Biosensors; CNiFERs; fast-scan cyclic voltammetry; frontal cortex; psychiatric disorders