Effect of Preoperative Opioid Exposure on Healthcare Utilization and Expenditures Following Elective Abdominal Surgery.
To examine the extent to which preoperative opioid use is correlated with healthcare utilization and costs following elective surgical procedures.



Morbidity and mortality associated with prescription opioid use is escalating in the United States. The extent to which chronic opioid use influences postoperative outcomes following elective surgery is not well understood.



Truven Health Marketscan Databases were used to identify adult patients who underwent elective abdominal surgery between June 2009 and December 2012 (n = 200,005). Generalized linear regression was used to determine the effect of preoperative opioid use on postoperative healthcare utilization (length of stay, 30-d readmission, and discharge destination) and cost (hospital stay, 90-, 180-, and 365-d) after adjusting for number of comorbidities, psychological conditions, and demographic characteristics.



In this cohort, 8.8% of patients used opioids preoperatively. Compared with non-users, patients using opioids preoperatively were more likely to have a longer hospital stay (2.9 d vs. 2.5 d, P <0.001) and were more likely to be discharged to a rehabilitation facility (3.6% vs. 2.5%, P <0.001), adjusting for covariates. Preoperative opioid use was also correlated with a greater rate of 30-day readmission (4.5% vs. 3.6%, P <0.001) and overall greater expenditures at 90- ($12036.60 vs. $3863.40, P <0.001), 180- ($16973.70 vs. $6790.60, P <0.001), and 365- ($25495.70 vs. $12113.80, P <0.001) days following surgery, adjusted for covariates. Additionally, dose-effects were observed regarding readmission, discharge destination, and late healthcare expenditures.



Preoperative interventions focused on opioid cessation and alternative analgesics may improve the safety and efficiency of elective surgery among chronic opioid users.
*Section of Plastic Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI †University of Michigan Medical School, Ann Arbor, MI ‡Section of Transplant Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI §Department of Anesthesia, University of Michigan Health System, Ann Arbor, MI.
Jennifer F
JF
Waljee
David C
DC
Cron
Rena M
RM
Steiger
Lin
L
Zhong
Michael J
MJ
Englesbe
Chad M
CM
Brummett
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D016208:Databases, Factual; D003695:Delivery of Health Care / Q000706:statistics & numerical data*; D013505:Digestive System Surgical Procedures / Q000191:economics / Q000379:methods; D017558:Elective Surgical Procedures / Q000191:economics* / Q000379:methods; D005260:Female; D005102:Health Expenditures / Q000706:statistics & numerical data*; D017721:Hospital Costs; D006801:Humans; D007902:Length of Stay / Q000191:economics; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000191:economics / Q000503:physiopathology / Q000628:therapy; D057234:Preoperative Period; D012189:Retrospective Studies; D014481:United States
D000701:Analgesics, Opioid