Effect of oxytocin pretreatment on cannabis outcomes in a brief motivational intervention.
Motivational enhancement therapy (MET) is efficacious in reducing cannabis use, yet benefits are generally short-lived. Oxytocin is a hypothalamic neuropeptide that promotes prosocial behaviors and plays a role in drug-related neuroadaptations; as such, oxytocin may enhance the effect of MET on cannabis outcomes. Cannabis dependent adults were randomized to receive MET plus oxytocin (n =8) or placebo (n =8). Participants receiving oxytocin showed reductions in amount of cannabis used daily and number of sessions per day. Participants receiving placebo did not evidence significant reductions. Powered clinical trials of oxytocin-enhanced MET for cannabis use disorder are warranted.
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: shermanb@musc.edu.
Brian J
BJ
Sherman
Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Nathaniel L
NL
Baker
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Aimee L
AL
McRae-Clark
D000293:Adolescent; D000328:Adult; D002188:Cannabis; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D008385:Marijuana Smoking / Q000523:psychology / Q000628:therapy; D062405:Motivational Interviewing / Q000379:methods*; D010120:Oxytocics / Q000008:administration & dosage; D010121:Oxytocin / Q000008:administration & dosage*; D010865:Pilot Projects; D016896:Treatment Outcome; D055815:Young Adult
D010120:Oxytocics; D010121:Oxytocin
Cannabis; Oxytocin; Treatment