Flavonoids from the roots of Artocarpus heterophyllus.
Four new flavonoids, artoheteroids A-D (1-4), together with six known ones (5-10), were isolated from the roots of Artocarpus heterophyllus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Among them, compounds 1-2, 4-6, and 10 were found to have suppression capabilities against CatK with IC50values ranging from 1.4 to 93.9μM.
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Wen-Jun
WJ
Yuan
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Jin-Bin
JB
Yuan
the People's Hospital of Yingshang, Yingshang 236200, China.
Jia-Bing
JB
Peng
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
Yuan-Qing
YQ
Ding
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Ji-Xiao
JX
Zhu
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA. Electronic address: firmblue@163.com.
Gang
G
Ren
D031622:Artocarpus / Q000737:chemistry*; D056657:Cathepsin K / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
D004791:Enzyme Inhibitors; D005419:Flavonoids; D056657:Cathepsin K
Artocarpus heterophyllus; Cathepsin K; Isoprenylated flavonoids; Structure elucidation