Bioprinting Using Mechanically Robust Core-Shell Cell-Laden Hydrogel Strands.
The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilizes core-shell cell-laden strands with a mechanically robust shell and an extracellular matrix-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core-shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs.
Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Pritesh
P
Mistry
Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Ahmed
A
Aied
Division of Surface Analysis and Biophysics, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Morgan
M
Alexander
Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Kevin
K
Shakesheff
FRAME Laboratory, School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Andrew
A
Bennett
Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Jing
J
Yang
D062028:Bioprinting; D002470:Cell Survival / Q000187:drug effects; D060833:Cellular Microenvironment / Q000187:drug effects; D005109:Extracellular Matrix / Q000187:drug effects; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry / Q000627:therapeutic use*; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
bioprinting; hydrogels; mechanical properties; tissue engineering