Genetic Affiliation of Pre-Hispanic and Contemporary Mayas Through Maternal Linage.
Maya civilization developed in Mesoamerica and encompassed the Yucatan Peninsula, Guatemala, Belize, part of the Mexican states of Tabasco and Chiapas, and the western parts of Honduras and El Salvador. This civilization persisted approximately 3,000 years and was one of the most advanced of its time, possessing the only known full writing system at the time, as well as art, sophisticated architecture, and mathematical and astronomical systems. This civilization reached the apex of its power and influence during the Preclassic period, from 2000 BCE to 250 CE. Genetic variation in the pre-Hispanic Mayas from archaeological sites in the Mexican states of Yucatan, Chiapas, Quintana Roo, and Tabasco and their relationship with the contemporary communities in these regions have not been previously studied. Consequently, the principal aim of this study was to determine mitochondrial DNA (mtDNA) variation in the pre-Hispanic Maya population and to assess the relationship of these individuals with contemporary Mesoamerican Maya and populations from Asia, Beringia, and North, Central, and South America. Our results revealed interactions and gene flow between populations in the different archaeological sites assessed in this study. The mtDNA haplogroup frequency in the pre-Hispanic Maya population (60.53%, 34.21%, and 5.26% for haplogroups A, C, and D, respectively) was similar to that of most Mexican and Guatemalan Maya populations, with haplogroup A exhibiting the highest frequency. Haplogroup B most likely arrived independently and mixed with populations carrying haplogroups A and C based on its absence in the pre-Hispanic Mexican Maya populations and low frequencies in most Mexican and Guatemalan Maya populations, although this also may be due to drift. Maya and Ciboneys sharing haplotype H10 belonged to haplogroup C1 and haplotype H4 of haplogroup D, suggesting shared regional haplotypes. This may indicate a shared genetic ancestry, suggesting more regional interaction between populations in the circum-Caribbean region than previously demonstrated. Haplotype sharing between the pre-Hispanic Maya and the indigenous populations from Asia, the Aleutian Islands, and North, Central, and South America provides evidence for gene flow from the ancestral Amerindian population of the pre-Hispanic Maya to Central and South America.
1 Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
Mirna Isabel
MI
Ochoa-Lugo
1 Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.|2 Laboratory of Biological Anthropology, University of Kansas, Lawrence, Kansas.
María de Lourdes
ML
Muñoz
1 Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
Gerardo
G
Pérez-Ramírez
2 Laboratory of Biological Anthropology, University of Kansas, Lawrence, Kansas.
Kristine G
KG
Beaty
3 Laboratorio de Genética del Instituto de Ciencias Forenses del Tribunal Superior de Justicia del Distrito Federal, Mexico City, Mexico.
Mauro
M
López-Armenta
4 Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California.|5 Universidad Autónoma Metropolitana Unidad Cuajimalpa, Mexico City, Mexico.
Javiera
J
Cervini-Silva
1 Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
Miguel
M
Moreno-Galeana
6 Department of Physical Anthropology, Instituto Nacional de Antropología e Historia, Mexico City, Mexico.
Adrián Martínez
AM
Meza
6 Department of Physical Anthropology, Instituto Nacional de Antropología e Historia, Mexico City, Mexico.
Eduardo
E
Ramos
2 Laboratory of Biological Anthropology, University of Kansas, Lawrence, Kansas.
Michael H
MH
Crawford
6 Department of Physical Anthropology, Instituto Nacional de Antropología e Historia, Mexico City, Mexico.|7 Universidad del Claustro de Sor Juana, Mexico City, Mexico.
Arturo
A
Romano-Pacheco
D001106:Archaeology; D004272:DNA, Mitochondrial / Q000235:genetics*; D019143:Evolution, Molecular; D051456:Gene Flow; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D007197:Indians, Central American / Q000235:genetics*; D058974:Phylogeography
D004272:DNA, Mitochondrial
america; ancient dna; indigenous people; mesoamerica; migration; mitochondrial dna; pre-hispanic populations