Genetic advances in craniosynostosis.
Craniosynostosis, the premature ossification of one or more skull sutures, is a clinically and genetically heterogeneous congenital anomaly affecting approximately one in 2,500 live births. In most cases, it occurs as an isolated congenital anomaly, that is, nonsyndromic craniosynostosis (NCS), the genetic, and environmental causes of which remain largely unknown. Recent data suggest that, at least some of the midline NCS cases may be explained by two loci inheritance. In approximately 25-30% of patients, craniosynostosis presents as a feature of a genetic syndrome due to chromosomal defects or mutations in genes within interconnected signaling pathways. The aim of this review is to provide a detailed and comprehensive update on the genetic and environmental factors associated with NCS, integrating the scientific findings achieved during the last decade. Focus on the neurodevelopmental, imaging, and treatment aspects of NCS is also provided.
Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Rome, Italy.|Latium Musculoskeletal Tıssue Bank, Rome, Italy.
Wanda
W
Lattanzi
Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Rome, Italy.
Marta
M
Barba
Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Rome, Italy.
Lorena
L
Di Pietro
Division of Genomic Medicine, Department of Pediatrics, Davis Medical Center, University of California, Sacramento, California.
Simeon A
SA
Boyadjiev
D000013:Congenital Abnormalities / Q000235:genetics* / Q000503:physiopathology; D003393:Cranial Sutures / Q000503:physiopathology; D003398:Craniosynostoses / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D009999:Ossification, Heterotopic / Q000235:genetics* / Q000503:physiopathology; D010641:Phenotype
craniofacial; craniosynostosis; gene mutations; malformation; skull sutures