Amplified nanostructure electrochemical sensor for simultaneous determination of captopril, acetaminophen, tyrosine and hydrochlorothiazide.
A novel nanomaterial-based voltammetric sensor has been developed for use a highly sensitive tool for the simultaneous determination of captopril (CA), acetaminophen (AC), tyrosine (TY) and hydrochlorothiazide (HCTZ). The device is based on the application of NiO/CNTs and (2-(3,4-dihydroxyphenethyl)isoindoline-1,3-dione) (DPID) to modify carbon paste electrodes. The NiO/CNTs nanocomposite was synthesized through a direct chemical precipitation approach and was characterized with X-ray powder diffraction (XRD), and scanning electron microscopy (SEM). The NiO/CNTs/DPID/CPEs were found to facilitate the analysis of CA, AC, TY and HCTZ in the concentration ranges of 0.07-200.0, 0.8-550.0, 5.0-750.0 and 10.0-600.0μM with the respective detection limits of 9.0nM, 0.3μM, 1.0μM and 5.0μM. The developed NiO/CNTs/DPID/CPEs were used for the determination of the mentioned analytes in pharmaceutical and biological real samples.
Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran. Electronic address: h.karimi.maleh@gmail.com.
Hassan
H
Karimi-Maleh
Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran.
Mohammad R
MR
Ganjali
Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran.
Parviz
P
Norouzi
Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran.
Asma
A
Bananezhad
D000082:Acetaminophen / Q000032:analysis* / Q000737:chemistry; D002216:Captopril / Q000032:analysis* / Q000737:chemistry; D055664:Electrochemical Techniques / Q000295:instrumentation*; D006801:Humans; D006852:Hydrochlorothiazide / Q000032:analysis* / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000648:ultrastructure; D009532:Nickel / Q000737:chemistry; D010084:Oxidation-Reduction; D014443:Tyrosine / Q000032:analysis* / Q000737:chemistry; D014961:X-Ray Diffraction
D037742:Nanotubes, Carbon; D006852:Hydrochlorothiazide; D000082:Acetaminophen; D014443:Tyrosine; D009532:Nickel; D002216:Captopril; C028007:nickel monoxide
Acetaminophen; Captopril; Hydrochlorothiazide, NiO/CNTs nanocomposite; Tyrosine