Case Report of Midazolam Withdrawal-Induced Catatonia in a 9-Year-Old Patient.
Benzodiazepine withdrawal-induced catatonia is a rare phenomenon in the adult population and has never been reported in a pediatric patient. We present a 9-year-old boy who exhibited catatonia symptoms following discontinuation of a midazolam infusion in the pediatric intensive care unit. The pediatric anesthesia acute pain team was consulted. When the patient's altered mental status could not otherwise be explained, benzodiazepine withdrawal-induced catatonia was considered. A dose of 2 mg intravenous lorazepam was given and the patient's symptoms dramatically improved within 5 minutes of administration. The patient was successfully treated with an oral diazepam taper.
From the Departments of *Anesthesiology; †Pharmacy: Clinical and Administrative Sciences; and ‡Pediatrics, Critical Care, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Cassandra R
CR
Duncan-Azadi
Peter N
PN
Johnson
Andrew
A
Gormley
D002389:Catatonia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D004334:Drug Administration Schedule; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D015278:Intensive Care Units, Pediatric; D008140:Lorazepam / Q000008:administration & dosage; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000009:adverse effects*; D011182:Postoperative Care; D012307:Risk Factors; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013997:Time Factors; D016896:Treatment Outcome
D006993:Hypnotics and Sedatives; D008140:Lorazepam; D008874:Midazolam