Intraocular Dexamethasone Implant as Adjunct to Silicone Oil Tamponade for Proliferative Vitreoretinopathy.
BackgroundProliferative vitreoretinopathy (PVR) occurs in 10 % of patients with retinal detachment and is characterized by excessive epi-, sub- or intraretinal contraction. Corticosteroids have been shown to counter this contraction.Patients and MethodsRetrospective review of 5 patients (3 females, 2 males) with recurrent retinal detachment with stage C PVR. The mean age was 61.2 ± 20.5 years and myopia > - 5.0 dioptres was present in 3 eyes. Patients were treated with 23 g vitrectomy, retinectomy and endolaser, dexamethasone (Ozurdex®) injection under perfluorocarbone and 5500 cs silicone oil tamponade.ResultsAfter a total follow-up of 8.8 ± 6.4 months with silicone oil tamponade, the Ozurdex® implant was localised in the macula in 1 case, and in 4 cases behind the iris with a completely attached retina. Preoperative intraocular pressure was 11.0 ± 4.0 mmHg, which remained stable at 7.8 ± 3.5 mmHg at the end of the final follow-up. No localised adverse effects were observed of the implant on the retina or the iris.ConclusionsThe dexamethasone implant Ozurdex® is well tolerated in conjunction with silicone oil tamponade in eyes with retinal detachment and PVR. The implant may be a potential candidate for the prevention of PVR.
Jules Gonin Eye Hospital, University of Lausanne, Switzerland.
M
M
Sherif
Jules Gonin Eye Hospital, University of Lausanne, Switzerland.
T J
TJ
Wolfensberger
D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant / Q000379:methods; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants / Q000008:administration & dosage*; D058450:Endotamponade / Q000379:methods*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D012827:Silicone Oils / Q000008:administration & dosage*; D016896:Treatment Outcome; D018630:Vitreoretinopathy, Proliferative / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*
D004343:Drug Implants; D012827:Silicone Oils; D003907:Dexamethasone