Bone mass loss is associated with systolic blood pressure in postmenopausal women with type 2 diabetes in Tibet: a retrospective cross-sectional study.
We conducted an observational cross-section study to investigate the status of bone mineral mass of Tibetan postmenopausal women with type 2 diabetes and the possible predictors for osteoporosis. We found that prevalence of osteoporosis was 27.0% and blood pressure was an independent risk factor for bone mass loss.



The aims of this study is to investigate the prevalence of osteoporosis in postmenopausal women with type 2 diabetes dwelling in Tibet and the possible risk factors for bone mass loss.



We recruited 99 Chinese Tibetan postmenopausal women with type 2 diabetes from the department of endocrinology of People's Hospital Tibet Autonomous Region. Multiple sites of bone mineral density (BMD) were measured by dual-energy X-ray absorptiometry (DXA). The subjects were divided into three groups based on BMD T-score: osteoporosis, osteopenia, and normal. The clinical characteristics were compared between groups. The risk factors for bone mass loss were assessed by multiple linear regression analysis.



Among diabetic postmenopausal women dwelling in high altitude, mean age was 62 ± 8 years, the median postmenopausal period was 12 years (5, 20), the median duration of diabetes mellitus was 3 years (1, 8), and mean BMI was 27.6 ± 4.2 kg/m2. Patients (52.5%) had hypertension. The percentages of patients with osteoporosis, osteopenia and normal BMD were 27.3, 42.4, and 30.3%, respectively. HbA1c and systolic blood pressure (SBP) were independently associated with T-scores of spine; ages and SBP were independently associated with T-scores of femoral neck or hip.



Among diabetic postmenopausal women dwelling in high altitude, 27.3% patients have osteoporosis, 42.4% patients have osteopenia, and 30.3% are normal. The BMD T-score of spine was inversely associated with SBP and positively associated with HbA1c, while the BMD T-score of femoral neck or hip was inversely associated with ages and SBP.
Department of Endocrinology and Metabolism, Peking University of People's Hospital, Beijing, China.
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L
Zhou
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
J
J
Song
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
S
S
Yang
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
S
S
Meng
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
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X
Lv
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
J
J
Yue
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
A
A
Mina
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
B
B
Puchi
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China.
Y
Y
Geng
Department of Endocrinology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China. 1640794768@qq.com.
L
L
Yang
D015502:Absorptiometry, Photon / Q000379:methods; D000368:Aged; D000531:Altitude; D001794:Blood Pressure / Q000502:physiology; D015519:Bone Density / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D018609:Tibet / Q000453:epidemiology
Bone mineral density; High altitude; Osteoporosis; Postmenopausal women; Type 2 diabetes