Amorphous nano-curcumin stabilized oil in water emulsion: Physico chemical characterization.
Particle characteristics e.g. size and polymorphism are known to significantly affect the Pickering ability of the solid particles by influencing their interaction at the oil and water (O/W) interface. In this study, nano-sized amorphous curcumin particles were fabricated using nanonization technology to use them as Pickering particles. After nanonization, native crystalline curcumin particles were converted into amorphous, nanosized particles of ∼220nm. Amorphous nature of the particle was evident from the decreased melting point from 177±1°C (native curcumin) to 146±3°C (nanonized curcumin) and enthalpy from 27±2J/g to 3.5±1J/g. Interfacial tension (IFT) studies have shown a decrease in IFT at the O/W interface from ∼27mN/m to ∼15mN/m in the presence of amorphous curcumin particles in water phase compared to crystalline curcumin particles. Curcumin stabilized O/W emulsion has an initial droplet size of ∼1.2μm and they were stable for 30days at 4°C.
School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: a.nayak.1@bham.ac.uk.
N P
NP
Aditya
School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Ian E
IE
Hamilton
School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Ian T
IT
Norton
D055598:Chemical Phenomena; D003474:Curcumin / Q000737:chemistry*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D004655:Emulsions; D014867:Water; D003474:Curcumin
Crystallization; Curcumin; Emulsion; Nanosuspension; Pickering particle; Stability