Clinical application of a gadolinium-based capsule as an MRI contrast agent in slow transit constipation diagnostics.
BACKGROUND
As a traditional method for the assessment of colon dynamics, radio-opaque markers (ROMs) are limited in clinical use because of their ionizing radiation. We compared the accuracy and applicability of gadolinium-based capsules with ROMs in the measurement of colon dynamics in healthy controls and slow transit constipation (STC) patients.


METHODS
Seven patients with STC and nine healthy controls under a normal diet orally consumed ROMs and gadolinium-based capsules simultaneously. All subjects underwent X-ray and magnetic resonance imaging (MRI). Healthy control images were acquired at 12, 24, and 48 h, and STC patient images were acquired at 24, 48, and 72 h. The scores based on the position of the labeling capsules and ROMs in the colon and the colon transit times (CTTs) in the two groups were compared.


RESULTS
The CTTs obtained via the ROMs were 34.7±17.4 and 67.3±6.5 h in the healthy controls and STC patients, respectively (P<.05). The CTTs obtained via MRI were 30.9±15.9 and 74.1±7.2 h in the healthy controls and STC patients, respectively (P<.05). The CTTs of the STC patients were significantly longer than the healthy controls. The correlation (rs) between the scores based on the position of the labeling capsule and ROMs in the healthy group and the STC patients was .880 (P<.05) and .889 (P<.05), respectively.


CONCLUSIONS
As a MRI contrast label, gadolinium-based capsules exhibit results comparable to ROMs in colon motility measurements.
Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
M
M
Zhi
Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Z
Z
Zhou
Department of Gastroenterology, Nanhai Hospital of Southern Medical University, Foshan, Guangdong Province, China.
H
H
Chen
Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
F
F
Xiong
Zhongshan World Medical Instruments Co., Ltd., Zhongshan, Guangdong Province, China.
J
J
Huang
Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
H
H
He
Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
M
M
Zhang
Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
M
M
Su
Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
X
X
Gao
Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
P
P
Hu
D000328:Adult; D002214:Capsules; D003248:Constipation / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011859:Radiography / Q000379:methods; D012680:Sensitivity and Specificity; D055815:Young Adult
D002214:Capsules; D003287:Contrast Media; D005682:Gadolinium

MRI
; ROMs; chronic constipation; colon transit dynamics; gadolinium-based capsule