Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance.
Crop breeding aims to balance disease resistance with yield; however, single resistance (R) genes can lead to resistance breakdown, and R gene pyramiding may affect growth fitness. Here we report that the ricePigmlocus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungusMagnaporthe oryzaewithout yield penalty. Among these NLR receptors, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance.PigmSexpression, and thusPigmR-mediated resistance, are subjected to tight epigenetic regulation.PigmSincreases seed production to counteract the yield cost induced byPigmRTherefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLR receptors, providing a tool to develop elite crop varieties.
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Yiwen
0000-0002-6074-5704
Y
Deng
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.|University of the Chinese Academy of Sciences, Beijing, China.
Keran
K
Zhai
College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Zhen
Z
Xie
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.|University of the Chinese Academy of Sciences, Beijing, China.
Dongyong
0000-0001-9368-2730
D
Yang
State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou, China.
Xudong
X
Zhu
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Junzhong
0000-0001-7751-6775
J
Liu
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Xin
X
Wang
State Key Laboratory of Hybrid Rice and Yahua Seeds Science Academy of Hunan, Changsha, China.
Peng
P
Qin
State Key Laboratory of Hybrid Rice and Yahua Seeds Science Academy of Hunan, Changsha, China.
Yuanzhu
Y
Yang
Heilongjiang Academy of Agricultural Sciences, Harbin, China.
Guomin
G
Zhang
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Qun
0000-0002-8111-8259
Q
Li
Fujian Academy of Agricultural Sciences, Fuzhou, China.
Jianfu
J
Zhang
Enshi Tujia and Miao Autonomous Prefecture Academy of Agricultural Sciences, Enshi, China.
Shuangqing
S
Wu
CIRAD (Centre de Coopération Internationale en Recherche Agronomique pour le Développement), UMR BGPI (Biologie et Génétique des Interactions Plante-Parasite), Montpellier, France.
Joëlle
J
Milazzo
College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Bizeng
B
Mao
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Ertao
0000-0002-5178-3530
E
Wang
Fujian Academy of Agricultural Sciences, Fuzhou, China.
Huaan
H
Xie
CIRAD (Centre de Coopération Internationale en Recherche Agronomique pour le Développement), UMR BGPI (Biologie et Génétique des Interactions Plante-Parasite), Montpellier, France.
Didier
0000-0003-3961-6120
D
Tharreau
National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China. zhhe@sibs.ac.cn.|College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.|Collaborative Innovation Center of Genetics and Development, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Zuhua
0000-0002-6098-7893
Z
He
D001947:Breeding; D018556:Crops, Agricultural / Q000235:genetics / Q000382:microbiology; D019175:DNA Methylation; D060467:Disease Resistance / Q000235:genetics*; D044127:Epigenesis, Genetic; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D056426:Genetic Loci; D020082:Magnaporthe; D005810:Multigene Family; D000070576:NLR Proteins / Q000737:chemistry / Q000235:genetics*; D012275:Oryza / Q000235:genetics / Q000382:microbiology*; D010935:Plant Diseases / Q000235:genetics / Q000382:microbiology*; D055503:Protein Multimerization
D000070576:NLR Proteins