Identification and Whole Genome Sequencing of the First Case ofKosakonia radicincitansCausing a Human Bloodstream Infection.
The taxonomy ofEnterobacterspecies is rapidly changing. Herein we report a bloodstream infection isolate originally identified asEnterobacter cloacaeby Vitek2 methodology that we found to beKosakonia radicincitansusing genetic means. Comparative whole genome sequencing of our isolate and other publishedKosakoniagenomes revealed these organisms lack the AmpC β-lactamase present on the chromosome ofEnterobactersp. A fimbriae operon primarily found inEscherichia coliO157:H7 isolates was present in our organism and other availableK. radicincitansgenomes. This is the first report of aKosakoniaspecies, which are typically associated with plants, causing a human infection.
Department of Microbiology, MD Anderson Cancer Center, Houston TX, USA.
Micah D
MD
Bhatti
Graduate Program in Diagnostic Genetics, School of Health Professions, MD Anderson Cancer Center, Houston TX, USA.
Awdhesh
A
Kalia
Department of Infectious Diseases, Infection Control and Employee Health, MD Anderson Cancer Center, Houston TX, USA.
Pranoti
P
Sahasrabhojane
Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas TX, USA.
Jiwoong
J
Kim
Division of Infectious Diseases, University of Texas Southwestern Medical Center, DallasTX, USA; Department of Microbiology, University of Texas Southwestern Medical Center, DallasTX, USA.
David E
DE
Greenberg
Department of Infectious Diseases, Infection Control and Employee Health, MD Anderson Cancer Center, HoustonTX, USA; Department of Genomic Medicine, MD Anderson Cancer Center, HoustonTX, USA.
Samuel A
SA
Shelburne
AmpC; Enterobacter; Kosakonia radicincitans; bloodstream infection; fimbriae