Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization.
By screening of reaction conditions and evaluation of its fluorescent properties, an environmentally sensitive fluorescent group, 8-aza-7-hydroxy-4-methylcoumarin, was synthesized in 70% yield using MgBr2as a Lewis acid under microwave irradiation. It has a high fluorescent quantum yield, is adequately soluble in water, and produces fluorescent emission in protic solvents and at neutral pH. Therefore, it could be useful in biosensors that are required to emit in hydrophilic environments such as cells.
Institution of Biomaterial and Bioengineering, Tokyo Medical and Dental University , 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Hikaru
H
Takano
Institution of Biomaterial and Bioengineering, Tokyo Medical and Dental University , 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Tetsuo
T
Narumi
Institution of Biomaterial and Bioengineering, Tokyo Medical and Dental University , 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Wataru
W
Nomura
Institution of Biomaterial and Bioengineering, Tokyo Medical and Dental University , 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Hirokazu
0000-0003-2788-2579
H
Tamamura
D001391:Azo Compounds / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D008872:Microwaves; D013057:Spectrum Analysis / Q000379:methods
D001391:Azo Compounds; D003374:Coumarins; D005456:Fluorescent Dyes