Assessment of the Anterior Chamber Flare and Macular Thickness in Patients Treated with Topical Antiglaucomatous Drugs.
To determine the changes in the anterior chamber flare and central macular thickness (CMT) under topical antiglaucomatous therapy.



This study included 121 eyes of 73 patients and 36 eyes of 18 controls. Glaucoma patients were divided into 3 groups (timolol maleate, latanoprost, and bimatoprost). Control eyes did not receive any medications. Flare and CMT measurements were performed at baseline and follow-up visits (15th day, and 1st, 3rd, 6th, and 12th month).



Statistically significant increases were detected in the flare values in the bimatoprost and latanoprost groups (P < 0.001, P = 0.011, respectively). Significant increases were also found in CMT values measured in these 2 groups (P < 0.001, P = 0.002, respectively). However, increased flare and CMT values were not clinically manifested as uveitis and macular edema. Flare and CMT values did not change statistically in the timolol maleate and control groups.



Although the use of prostaglandin (PG) analogs was found to be associated with increased flare and CMT, these increases were not clinically significant. PG analog monotherapy may be safely and effectively used in the treatment of glaucoma.
Department of Ophthalmology, Faculty of Medicine, Ankara University , Ankara, Turkey .
Fırat
F
Selen
Department of Ophthalmology, Faculty of Medicine, Ankara University , Ankara, Turkey .
Oya
O
Tekeli
Department of Ophthalmology, Faculty of Medicine, Ankara University , Ankara, Turkey .
Özge
Ö
Yanık
D000287:Administration, Topical; D000867:Anterior Chamber / Q000187:drug effects* / Q000473:pathology; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000069580:Bimatoprost / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D000077338:Latanoprost; D008268:Macular Degeneration / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*
D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D013999:Timolol; D000069580:Bimatoprost
central macular thickness; flare; glaucoma; macular edema; prostaglandins