What Are the Most Powerful Immunogen Design Vaccine Strategies? A Structural Biologist's Perspective.
The ability of structure-based design to control the shape and reactivity-the atomic-level chemistry-of an immunogen argues for it being one of the "most powerful" immunogen-design strategies. But antigenic reactivity is only one of the properties required to induce a protective immune response. Here, a multidimensional approach is used to exemplify the enabling role atomic-level information can play in the development of immunogens against three viral pathogens, respiratory syncytial virus, influenza A virus, and human immunodeficiency virus (HIV), which have resisted standard approaches to vaccine development. Overall, structure-based strategies incorporating B-cell ontogenies and viral evasion mechanisms appear exceptionally powerful.
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Peter D
PD
Kwong
D015195:Drug Design; D006801:Humans; D057131:Immune Evasion; D015394:Molecular Structure; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D014614:Vaccines, Synthetic; D014765:Viral Vaccines