Benign prostatic hyperplasia after prostatic arterial embolization in a canine model: A 3T multiparametric MRI and whole-mount step-section pathology correlated longitudinal study.
To explore the morphological and functional characteristics of prostatic arterial embolization (PAE) in a canine model of benign prostatic hyperplasia (BPH) with 3T multiparametric magnetic resonance imaging (mp-MRI) and whole-mount step-section pathology correlation.



Eight adult male beagle dogs with hormone-induced BPH underwent 3T mp-MRI before and 1, 3, and 6 months after PAE, with subsequent whole-mount step-section pathologic assessment. Images were acquired using T1-weighted images (T1WI), T2WI, 3D-SPACE, diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), T2-mapping, and dynamic contrast-enhanced (DCE) sequences. Variance analysis was performed to assess statistical differences in prostatic volume (PV), apparent diffusion coefficient (ADC), and T2values. Pearson correlation analysis was performed to correlate ADC, T2, and PV.



The PV decreased from baseline to 1, 3, and 6 months after PAE from (25.88 ± 7.09) cm3to (6.48 ± 2.08) cm3, (6.48 ± 3.39) cm3, (6.20 ± 2.88) cm3. The ADC values sequentially decreased from baseline to 1, 3, and 6 months after PAE from (1497.06 ± 222.72) × 10-6mm2/s to (1056.00 ± 189.46) × 10-6mm2/s, (950.48 ± 77.85) × 10-6mm2/s, (980.98 ± 107.78) × 10-6mm2/s. The T2values decreased from baseline to 1, 3, and 6 months after PAE were (83.74 ± 5.29) msec, (68.72 ± 5.66) msec, (53.96 ± 15.04) msec, (49.81 ± 13.34) msec, respectively. ADC and T2values were positively correlated with PV (r = 0.823 and 0.744, respectively). Microhemorrhages and hemosiderin were found on SWI after PAE.



3T mp-MRI may facilitate noninvasive assessment of morphological and functional changes of BPH after PAE.



1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1220-1229.
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Basen
B
Li
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Anhui
A
Xu
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Nan
N
Wang
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Xiangde
X
Min
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Zhaoyan
Z
Feng
Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.
Ming
M
Deng
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, P.R. China.
Liang
L
Li
Department of Interventional Radiology, First People's Hospital of Jingzhou, Yangtze University, Jingzhou, P.R. China.
Jie
J
Cai
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Zhen
Z
Kang
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Kehua
K
Jiang
Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Dong
D
Kuang
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Liang
L
Wang
D000818:Animals; D003287:Contrast Media; D004195:Disease Models, Animal; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011467:Prostate / Q000098:blood supply* / Q000000981:diagnostic imaging*; D011470:Prostatic Hyperplasia / Q000000981:diagnostic imaging* / Q000628:therapy*
D003287:Contrast Media
benign prostatic hyperplasia; canine model; magnetic resonance imaging; prostatic arterial embolization