Albumin-Mediated Biomineralization of Shape-Controllable and Biocompatible Ceria Nanomaterials.
Although ceria-based nanostructures have emerged as fascinating materials with diverse biological activities, developing a facile, rapid, and biocompatible method of their preparation remains a major challenge. Herein we describe bovine serum albumin (BSA) protein-directed synthesis of ceria-based nanostructures, including ceria nanoclusters (CNLs), nanoparticles (CNPs), and nanochains (CNHs). Their preparation is simple, one-pot, and performed in a mild reaction condition with a "green" synthetic approach. Most importantly, these three kinds of ceria-based nanostructures can be synthesized in a shape and size controllable manner by tuning the reaction time, temperature, and molar ratio. The formation mechanism shows that growth of these ceria nanostructures is mediated by Ce3+/Ce4+switchable redox system, reducible disulfide bonds, and unique spatial structures in albumin proteins. More importantly, these albumin-based ceria nanostructures exhibit high superoxide dismutase (SOD) mimetic activity and good biocompatibility, providing a promising prospect in biomedical application.
Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University , Chongqing, 400038, China.
Zhangyou
Z
Yang
Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University , Chongqing, 400038, China.
Shenglin
S
Luo
Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University , Chongqing, 400038, China.
Yiping
Y
Zeng
Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University , Chongqing, 400038, China.
Chunmeng
C
Shi
Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University , Chongqing, 400038, China.
Rong
http://orcid.org/0000-0002-2980-4550
R
Li
D000818:Animals; D053758:Nanoparticles; D049329:Nanostructures; D010084:Oxidation-Reduction; D012710:Serum Albumin, Bovine
D012710:Serum Albumin, Bovine
BSA; biocompatibility; ceria nanostructure; green synthesis; metal−protein complex