Identification of novel ROS inducer by merging the fragments of piperlongumine and dicoumarol.
A series of novel ROS inducers were designed by merging the fragments of piperlongumine and dicoumarol. Most of these derivatives showed potent in vitro activity against three cancer cell lines and good selectivity towards normal lung cells. The most potent and selective compound 3e was proven to exhibit obvious ROS elevation and excellent in vivo antitumor activity with suppressed tumor growth by 48.46% at the dose of 5mg/kg. Supported by these investigation, these findings encourage further investigation around this interesting antitumor chemotype.
School of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng, China. Electronic address: xxjyctu@163.com.
Xiaojuan
X
Xu
School of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng, China.
Xia
X
Fang
School of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng, China.
Jun
J
Wang
School of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng, China.
Hong
H
Zhu
D000072283:A549 Cells; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D001728:Dicumarol / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004148:Dioxolanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D064593:Heterografts; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D017382:Reactive Oxygen Species / Q000378:metabolism; D010881:Piperidones
D000970:Antineoplastic Agents; D001728:Dicumarol; D004148:Dioxolanes; D017382:Reactive Oxygen Species; C498077:piperlongumine; D010881:Piperidones
Antitumor; Biological activity; Dicoumarol; Piperlongumine; Reactive oxygen species