The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis.
BACKGROUND
Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migraine. However, their roles in this disorder are not well established. Then we conduct this meta-analysis to address this issue.


METHODS
PubMed, Web of Science and Cochrane databases were systematically searched to identify all relevant studies. Odds ratio (OR) with corresponding 95% confidence interval (CI) was used to estimate the strength of association between BDNF gene rs6265 and rs2049046 polymorphism and migraine.


RESULTS
Four studies with 1598 cases and 1585 controls, fulfilling the inclusion criteria were included in our meta-analysis. Overall data showed significant association between rs6265 polymorphism and migraine in allele model (OR = 0.86, 95%CI: 0.76-0.99, p = 0.03), recessive model (OR = 0.84, 95%CI: 0.72-0.98, p = 0.03) and additive model (GG vs GA: OR = 0.85, 95%CI: 0.72-1.00, p = 0.04), respectively. We also found significant association between rs2049046(A/T) polymorphism and migraine in allele model (OR = 0.88, 95%CI: 0.79-0.98, p = 0.02), recessive model (OR = 0.80, 95%CI: 0.67-0.96, p = 0.02) and additive model (AA vs TT: OR = 0.72, 95%CI: 0.57-0.92, p = 0.008; AA vs AT: OR = 0.81, 95%CI: 0.67-0.99, p = 0.03), respectively.


CONCLUSIONS
Our meta-analysis suggested that BDNF rs6265 and rs2049046 polymorphism were associated with common migraine in Caucasian population. Further studies are awaited to update this finding in Asian population and other types of migraine.
Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong, 510080, China.
Xiaoying
X
Cai
Department of Neurology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Anhui, 241001, China.
Xiaolei
X
Shi
Department of Neurology, The First Affiliated Hospital, Soochow University, No. 188 Shizi Road, Jiangsu, 215000, China.
Ximeng
X
Zhang
Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong, 510080, China.
Aiwu
A
Zhang
Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong, 510080, China.
Minying
M
Zheng
Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong, 510080, China. fyn2012@126.com.
Yannan
Y
Fang
D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D044465:White People / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
BDNF; Migraine; Val66Met polymorphism; rs2049046; rs6265