Subthalamic nucleus deep brain stimulation affects distractor interference in auditory working memory.
Computational and theoretical accounts hypothesize the basal ganglia play a supramodal "gating" role in the maintenance of working memory representations, especially in preservation from distractor interference. There are currently two major limitations to this account. The first is that supporting experiments have focused exclusively on the visuospatial domain, leaving questions as to whether such "gating" is domain-specific. The second is that current evidence relies on correlational measures, as it is extremely difficult to causally and reversibly manipulate subcortical structures in humans. To address these shortcomings, we examined non-spatial, auditory working memory performance during reversible modulation of the basal ganglia, an approach afforded by deep brain stimulation of the subthalamic nucleus. We found that subthalamic nucleus stimulation impaired auditory working memory performance, specifically in the group tested in the presence of distractors, even though the distractors were predictable and completely irrelevant to the encoding of the task stimuli. This study provides key causal evidence that the basal ganglia act as a supramodal filter in working memory processes, further adding to our growing understanding of their role in cognition.
Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: corrie.camalier@gmail.com.
Corrie R
CR
Camalier
Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Alice Y
AY
Wang
Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Lindsey G
LG
McIntosh
Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Sohee
S
Park
Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Joseph S
JS
Neimat
D000368:Aged; D001288:Attention / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001479:Basal Ganglia / Q000502:physiology* / Q000503:physiopathology; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D020531:Subthalamic Nucleus / Q000502:physiology* / Q000503:physiopathology
Basal ganglia; Domain general; Non-spatial, Parkinson's disease; Phonological; Subthalamic nucleus; Working memory