Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations.
Purpose To investigate the prevalence of diffuse pulmonary ossification (DPO) in patients with fibrosing interstitial lung disease (ILD) and determine whether there are differences among the types of ILDs. Materials and Methods Institutional review board approval was given and patient consent was not required for this study. The study population comprised 892 consecutive patients with fibrosing ILD, including 456 patients with idiopathic pulmonary fibrosis (IPF) (men, 366; women, 90; median age, 72 years [range, 38-93 years]), 244 with nonspecific interstitial pneumonia (men, 79; women, 165; median age, 60.5 years [range, 23-86 years]), and 192 with chronic hypersensitivity pneumonitis (men, 76; women, 116; median age, 66 years [range, 35-88 years]). Pulmonary ossifications were recorded when nodules (<4 mm diameter) were identified on bone window images (width, 2500 HU; level, 500 HU). DPO was defined as 10 or more bilateral nodular ossifications (definition 1) or as one or more lobes with five or more bilateral nodular ossifications (definition 2). Relationships among pulmonary ossification and parenchymal patterns, clinical parameters, and multidisciplinary team diagnoses were examined. The prevalence of DPO was compared with the χ2statistic or Fisher exact test, and multivariate analysis was performed with logistic regression. Results In the whole population, the prevalence of DPO was 166 (18.6%) and 106 (11.9%) of 892 patients according to definitions 1 and 2, respectively. The prevalence of DPO (definition 1) was significantly higher in patients with IPF (28.5%) than in those without IPF (8.3%, P < .001). Nine of 192 (4.7%) had chronic hypersensitivity pneumonitis (P < .001), and 27 of 244 (11.1%) had nonspecific interstitial pneumonia (P < .001). At multivariate analysis, DPO according to definition 1 was an independent predictor of IPF diagnosis (P < .001) and male sex (P = .003). Coarseness of fibrosing ILD (P = .011) and IPF diagnosis (P = .016) were independently associated with pulmonary ossification profusion. Conclusion DPO is common in patients with fibrosing ILD and is significantly more prevalent in patients with IPF than in those with other fibrosing ILDs, and thus, computed tomographic signs of DPO may be helpful for diagnosis of IPF.©RSNA, 2017 Online supplemental material is available for this article.
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
Ryoko
R
Egashira
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
Joseph
J
Jacob
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
Maria A
MA
Kokosi
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
Anne-Laure
AL
Brun
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
Alexandra
A
Rice
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
Andrew G
AG
Nicholson
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
Athol U
AU
Wells
From the Department of Radiology (R.E., J.J., A.L.B., D.M.H.), Interstitial Lung Disease Unit (M.K., A.U.W.), and Department of Histopathology (A.R., A.G.N.), Royal Brompton and Harefield NHS Foundation Trust, London, England.
David M
DM
Hansell
D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015995:Prevalence; D014057:Tomography, X-Ray Computed / Q000379:methods*