Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells.
Apoptosis of renal proximal tubular epithelial cells (PTECs) plays a vital role in the pathogenesis and progression of diabetic kidney disease (DKD). Calcium dobesilate is a vascular protective compound used for treatment of diabetic retinopathy and chronic venous insufficiency. The aim of this study was to determine whether calcium dobesilate can protect PTECs from glucose-induced apoptosis and the potential mechanism of this effect. It is indicated that high glucose promoted abnormal apoptosis of HK2 cells, which was inhibited by treatment of calcium dobesilate, while Bim expression decreased in response to calcium dobesilate in high-glucose-treated HK2 cells. These findings confirmed the therapeutic effects of calcium dobesilate on DKD and emphasized the importance of it as a potentially crucial drug in treatment of DKD.
1 Department of Medicine, Division of Traditional Chinese Medicine, Tai'an Hospital of Traditional Chinese Medicine , Tai'an, China .
Tian
T
Cai
2 Department of Medicine, Division of Geriatrics, First People's Hospital of Yunnan Province , Kunming, China .
Xiao-Yun
XY
Wu
3 Department of Medicine, Division of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University , Jinan, China .
Xiao-Qian
XQ
Zhang
3 Department of Medicine, Division of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University , Jinan, China .
Hong-Xia
HX
Shang
3 Department of Medicine, Division of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University , Jinan, China .
Zhong-Wen
ZW
Zhang
3 Department of Medicine, Division of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University , Jinan, China .
Lin
L
Liao
4 Department of Medicine, Division of Endocrinology, Qilu Hospital of Shandong University, Shandong University , Jinan, China .
Jian-Jun
JJ
Dong
D017209:Apoptosis; D000072224:Bcl-2-Like Protein 11 / Q000378:metabolism*; D002123:Calcium Dobesilate / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D003928:Diabetic Nephropathies / Q000517:prevention & control; D004847:Epithelial Cells / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000187:drug effects*
D000072224:Bcl-2-Like Protein 11; D002123:Calcium Dobesilate; D005947:Glucose
Bim; apoptosis; diabetic kidney disease; proximal tubular epithelial cells