Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.
EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway inDrosophilaembryogenesis. We review the existing body of evidence concerning EGF signaling inDrosophilaembryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing theDrosophilamodel system for research into EGF effects on cancer.
Division of Science, Yale-NUS College, Singapore 138527, Singapore. jay.lusk@u.yale-nus.edu.sg.
Jay B
JB
Lusk
Division of Science, Yale-NUS College, Singapore 138527, Singapore. ynclamy@nus.edu.sg.
Vanessa Y M
VY
Lam
Division of Science, Yale-NUS College, Singapore 138527, Singapore. Nicholas.Towlinski@yale-nus.edu.sg.|Department of Biological Science, National University of Singapore, Singapore 138615, Singapore. Nicholas.Towlinski@yale-nus.edu.sg.
Nicholas S
NS
Tolwinski
Drosophila development; EGF signaling; MAP kinase; MEK; RAF; RAS