The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia.
An intriguing piece of evidence for the inflammatory story of type 2 diabetes has come to the light. A recent study by Okin and colleagues adds new clues to the interplay between cholesterol metabolism and immunity and how it impacts glucose homeostasis in inflammatory conditions. But some questions are a still unsolved conundrum. Here we suggest to better dissect the regulatory mechanism of Mevalonate pathway and to underpin a new causative link between immunometabolic dysregulation and diabetes.
Department of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081, Salerno, Italy. maubiful@unisa.it.|CORPOREA-Fondazione Idis-Città della Scienza, via Coroglio 104 e 57, 80124, Naples, Italy. maubiful@unisa.it.
Maurizio
M
Bifulco
Department of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081, Salerno, Italy.
Simona
S
Pisanti
Department of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081, Salerno, Italy.
Elena
E
Ciaglia
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D022781:Hepatocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D007249:Inflammation / Q000276:immunology* / Q000473:pathology*; D053858:Metabolic Networks and Pathways; D008798:Mevalonic Acid / Q000378:metabolism
D002784:Cholesterol; D005947:Glucose; D008798:Mevalonic Acid
Diabetes; Inflammation; Isoprenoids; Metabolism; Mevalonate pathway