Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue.
Obesity-induced inflammatory changes in white adipose tissue (WAT), which caused dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-αand monocyte chemoattractant protein-1, contribute to the development of insulin resistance. Moreover, current literature reports state that WAT generates reactive oxygen species (ROS), and the enhanced production of ROS in obese WAT has been closely associated with the dysregulated expression of adipokines in WAT. Therefore, the reduction in excess WAT and oxidative stress that results from obesity is thought to be one of the important strategies in preventing and improving lifestyle-related diseases. Exercise training (TR) not only brings about a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the adipokines in WAT. Furthermore, some reports indicate that TR affects the generation of oxidative stress in WAT. This review outlines the impact of TR on the expression of inflammation-related adipokines and oxidative stress in WAT.
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.
Takuya
0000-0003-0135-8525
T
Sakurai
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.
Junetsu
0000-0003-1761-9806
J
Ogasawara
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.
Ken
0000-0002-3151-9417
K
Shirato
Department of Sports Biochemistry, Faculty of Health and Sport Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto, Japan.
Tetsuya
0000-0001-5197-9085
T
Izawa
National Hospital Organization Ibarakihigashi National Hospital, The Center of Chest Diseases and Severe Motor and Intellectual Disabilities, Terunuma 825, Tokai-mura, Naka-gun, Ibaraki, Japan.
Shuji
0000-0002-3149-8775
S
Oh-Ishi
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.
Yoshinaga
Y
Ishibashi
Institute of Sport Science, University of Physical Education, Alkotas u. 44, TF, Budapest, Hungary.
Zsolt
0000-0003-1297-6804
Z
Radák
Social Medical Corporation, The Yamatokai Foundation, Nangai, Higashiyamato, Tokyo, Japan.
Hideki
H
Ohno
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.
Takako
0000-0001-9222-8771
T
Kizaki
D054392:Adipokines / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018384:Oxidative Stress
D054392:Adipokines