Intravitreal Antiangiogenic Therapy of Uveitic Macular Edema: A Review.
Uveitic (or inflammatory) macular edema (UME) is one of the most common cause of visual impairment in patients with uveitis and the most frequent structural complication of uveitis. The use of antiangiogenic agents in the management of macular edema due to inflammation is a fairly new approach. It is not entirely clear if these agents should be used as an adjunct to anti-inflammatory therapy or if they can be used as stand-alone agents in edema due to infections where immunosuppressive therapy could be detrimental to the resolution of infection. This treatment paradigm is largely borrowed from large randomized trials in other retinovascular diseases. Similar prospective studies are needed to clarify the role of antiangiogenic therapy in UME.
1 King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia .|2 Moorfields Eye Hospital Centre , Abu Dhabi, United Arab Emirates .
Igor
I
Kozak
3 The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia .
Samir S
SS
Shoughy
1 King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia .|4 Wilmer Ophthalmological Institute, Johns Hopkins University , Baltimore, Maryland.
Donald U
DU
Stone
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000150:complications* / Q000188:drug therapy*; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy*
D020533:Angiogenesis Inhibitors
aflibercept; antiangiogenic agents; bevacizumab; macular edema; ranibizumab; uveitis