Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre.
Yamamotoet al. have studied T follicular helper (TFH) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of TFH, reproducing infection-associated TFHaccumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate TFHIL4andCD154expression with superior antibody responses. Accumulation of TFHwas accompanied by aberrant expression of non-TFHtranscriptional regulators such asBLIMP1in TFH, suggesting viral induced abnormalities may affect TFHfunction.
Department of Renal Medicine, The Canberra Hospital, Canberra, Australia.
Tom N
TN
Lea-Henry
Department of Renal Medicine, The Canberra Hospital, Canberra, Australia; ; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Acton, Australia.
Simon H
SH
Jiang
T follicular helper cells; antibody; germinal centre (GC); human immunodeficiency virus (HIV); simian immunodeficiency virus (SIV)