Thrombotic Microangiopathy in a Patient Treated With Gemcitabine.
Thrombotic microangiopathy syndromes consist of a collection of disorders with a varied etiology that share common clinical and pathological features. Although thrombotic microangiopathy is rare, it is associated with significant morbidity and mortality. Without early recognition and intervention, the prognosis of the disease is poor. This report illustrates the case of a 56-year-old man with advanced-stage metastatic pancreatic cancer who presented with hemolytic uremic syndrome associated with gemcitabine use. His condition was managed with eculizumab, a monoclonal antibody, although he was dependent on dialysis. This report reflects the importance of considering thrombotic microangiopathy syndromes in the differential diagnosis, because many malignancies and use of chemotherapeutic agents can trigger hemolytic uremic syndrome.
Department of Internal Hospital Medicine, Moffitt Cancer Center and University of South Florida Morsani College of Medicine, Tampa, FL. Sowmya.Nanjappa@Moffitt.org.
Sowmya
S
Nanjappa
Moffitt Cancer Center, Tampa, FL.
Vivek
V
Singh
Tampa Renal Physicians, Tampa, FL.
Shyam
S
Uttamchandani
Department of Internal Hospital Medicine, Moffitt Cancer Center, Tampa, FL.
Smitha
S
Pabbathi
D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006463:Hemolytic-Uremic Syndrome / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000556:secondary; D057049:Thrombotic Microangiopathies / Q000139:chemically induced* / Q000188:drug therapy; D000093542:Gemcitabine
D061067:Antibodies, Monoclonal, Humanized; D003841:Deoxycytidine; C481642:eculizumab; D017239:Paclitaxel; D000093542:Gemcitabine