Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence.
Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.
Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Haoyuan
H
Huang
Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Saurabh
S
Chauhan
Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Jumin
J
Geng
Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Yiru
Y
Qin
Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
David F
0000-0003-1203-2811
DF
Watson
Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Jonathan F
0000-0002-9052-884X
JF
Lovell
D000818:Animals; D005453:Fluorescence; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D019736:Prostheses and Implants; D013050:Spectrometry, Fluorescence; D014001:Tin / Q000737:chemistry*
D020100:Hydrogels; D011108:Polymers; D011166:Porphyrins; D011092:Polyethylene Glycols; D014001:Tin