Endoneurial-CD34 positive cells define an intermediate layer in human digital Pacinian corpuscles.
The endoneurial and/or perineurial origin of the outer core; i.e. the concentric and continuous lamellae located outside the complex formed by the axon and the Schwann-related cells, in human Pacinian corpuscles is still debated. Here we used immunohistochemistry coupled with a battery of antibodies to investigate the expression of perineurial (Glucose transporter 1 and epithelial membrane antigen) or endoneurial (CD34 antigen) markers in human digital Pacinian corpuscles. CD34 immunoreactivity was restricted to one layer immediately outside the inner core, whereas the proper outer core displayed antigens typical of the perineurial cells. These results demonstrate an intermediate endoneurial layer that divides the Pacinian corpuscles into two distinct compartments: the avascular inner neural compartment (formed by the axon and the Schwann-related cells that form the inner core), and the outer non-neural compartment (formed by the outer core). The functional relevance of these findings, if any, remains to be clarified.
Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Spain.
J
J
García-Piqueras
Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Spain.
O
O
García-Suárez
Servicio de Anatomía Patológica, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.
M C
MC
Rodríguez-González
Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Spain.
J L
JL
Cobo
Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Spain.
R
R
Cabo
Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Spain; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
J A
JA
Vega
Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Spain; Servicio de Anatomía Patológica, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain. Electronic address: jfeito@saludcastillayleon.es.
J
J
Feito
D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism*; D002102:Cadaver; D005260:Female; D005385:Fingers / Q000033:anatomy & histology / Q000294:innervation; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D010141:Pacinian Corpuscles / Q000166:cytology* / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism* / Q000648:ultrastructure*; D014018:Tissue Distribution; D055815:Young Adult
D018952:Antigens, CD34; D051272:Glucose Transporter Type 1; D018396:Mucin-1
CD34 antigen; Endoneurium; Human; Immunohistochemistry; Pacinian corpuscles