Early periprosthetic joint infection and debridement, antibiotics and implant retention in arthroplasty for femoral neck fracture.
BACKGROUND
Periprosthetic joint infection (PJI) is a severe complication of hip arthroplasty for femoral neck fractures (FNF). Debridement, antibiotics and implant retention (DAIR) is recommended in early PJI in association with stable implants. Few studies have evaluated the outcome of DAIR in this fragile population.The purpose of this study was to analyse risk factors for PJI and the short-term outcome of DAIR in FNF patients treated with a hip arthroplasty.


METHODS
A consecutive series of 736 patients (median age 81 years, 490 women, 246 men) had been treated with either a total hip arthroplasty or a hemi hip arthroplasty for a displaced FNF at our institution. 33 (4.5%) of the hips developed an early (<6 weeks post operatively) PJI and 28 (3.8%) of these patients were treated according to the DAIR-protocol. Regression analyses were performed to assess risk factors for developing a PJI.


RESULTS
DAIR eradicated the PJI in 82% (23/28) of patients at a median follow-up of 31 (SD 29.8) months of the infected hips.The logistic regression analysis indicated that 2 or more changes of the primary dressing due to wound bleeding was associated with an increased risk for developing PJI (OR 4.9, 95% 1.5 to 16.1, p = 0.01).


CONCLUSIONS
The short-term success-rate of DAIR was unexpectedly favourable in this fragile patient population; the results being on par with that after PJI in osteoarthritis patients. The need for repeated bandage changes postoperatively indicates an increased risk for PJI and should prompt early surgical intervention.
Department of Surgical and Perioperative Sciences, Umeå University, Umeå - Sweden.
Carl
C
Mellner
Department of Clinical Sciences at Danderyd Hospital (KIDS), Karolinska Institutet, Stockholm - Sweden.
Thomas
T
Eisler
Department of Surgical and Perioperative Sciences, Umeå University, Umeå - Sweden.
Björn
B
Knutsson
Department of Surgical and Perioperative Sciences, Umeå University, Umeå - Sweden.
Sebastian
S
Mukka
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000379:methods; D015331:Cohort Studies; D016001:Confidence Intervals; D016208:Databases, Factual; D003646:Debridement / Q000379:methods; D005260:Female; D005265:Femoral Neck Fractures / Q000000981:diagnostic imaging / Q000601:surgery*; D005500:Follow-Up Studies; D006622:Hip Prosthesis; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D016017:Odds Ratio; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging / Q000628:therapy*; D012189:Retrospective Studies; D018570:Risk Assessment; D013548:Sweden; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents