Roles of palmitoylation in axon growth, degeneration and regeneration.
The protein-lipid modification palmitoylation plays important roles in neurons, but most attention has focused on roles of this modification in the regulation of mature pre- and post-synapses. However, exciting recent findings suggest that palmitoylation is also critical for both the growth and integrity of neuronal axons and plays previously unappreciated roles in conveying axonal anterograde and retrograde signals. Here we review these emerging roles for palmitoylation in the regulation of axons in health and disease. © 2017 Wiley Periodicals, Inc.
Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair).
Sabrina M
SM
Holland
Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair).|Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140.
Gareth M
GM
Thomas
D000818:Animals; D001369:Axons / Q000502:physiology*; D006801:Humans; D054878:Lipoylation / Q000502:physiology*; D009410:Nerve Degeneration / Q000378:metabolism / Q000503:physiopathology*; D009416:Nerve Regeneration / Q000502:physiology*; D000071446:Neuronal Outgrowth / Q000502:physiology*
Axon degeneration; DLK; Peripheral Neuropathy; Protein trafficking; Retrograde Transport; Wallerian