Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility.
Hydroxyapatite (HA) is the major inorganic component of natural bone tissue. As an essential trace element, selenium involves in antioxidation and anticancer of human body. So far, ion-doped hydroxyapatites (HAs) are widely investigated owing to their great applications in field of biomaterial, biological labeling. In this paper, series of monodisperse HA doped with SeO32-(SeHA) was successfully synthesized based on the liquid-solid-solution (LSS) strategy. The obtained samples were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and energy-dispersive spectrometer (EDS). The results indicated that the SeO32-doping level of the Se/(P+Se) molar ratio of 0-0.4 can be requisitely controlled, and the morphology of SeHA nanoparticles varied from nanorods to nanoneedles with increasing Se/(P+Se) molar ratio. Significantly, the as-synthesized SeHA nanocrystals exhibit a low cytotoxicity for osteoblastic cells, showing exciting potentials for application in artificial scaffold materials inhibiting of tumor growth in bone.
School of Civil Engineering, Xi'an University of Architecture and Technology, Shaanxi 710055, PR China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
Jianpeng
J
Sun
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
Xiaoyan
X
Zheng
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
Hui
H
Li
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
Daidi
D
Fan
School of Civil Engineering, Xi'an University of Architecture and Technology, Shaanxi 710055, PR China.
Zhanping
Z
Song
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
Haixia
H
Ma
Department of Scientific Research and Development, Tsinghua University, Beijing 100084, PR China. Electronic address: hua_xiufu@163.com.
Xiufu
X
Hua
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China. Electronic address: huijunfeng@126.com.
Junfeng
J
Hui
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D048430:Cell Shape / Q000187:drug effects; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D012643:Selenium / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D017886:Durapatite; D012643:Selenium
Biocompatibility; Controllable synthesis; Hydroxyapatite; Selenium