Biologic Variation Approach to Daily Laboratory.
Biological variation gives valuable information about how the living organism regulates its constituents within and between subjects; this information on the behavior of body components allows us to derive consequences concerning reference populations and intervals. With a more pragmatic approach biological variation has three uses: setting the appropriate analytical performance specification for each analyte to limit the amount of error that laboratory could introduce in its measurements, to help distinguish health from disease, and to implement internal quality control with the automatic verification of results.
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain. Electronic address: cperich.bcn.ics@gencat.cat.
Carmen
C
Ricós
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Virtudes
V
Álvarez
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Joana
J
Minchinela
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Pilar
P
Fernández-Calle
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Carmen
C
Perich
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Beatriz
B
Boned
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Elisabet
E
González
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Margarita
M
Simón
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Jorge
J
Díaz-Garzón
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
José Vicente
JV
García-Lario
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Fernando
F
Cava
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Pilar
P
Fernández-Fernández
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Zoraida
Z
Corte
Spanish Society of Laboratory Medicine (SEQC), Commission of Analytical Quality, Spain.
Carmen
C
Biosca
D001826:Body Fluids / Q000737:chemistry* / Q000502:physiology; D019411:Clinical Laboratory Techniques / Q000379:methods*; D003951:Diagnostic Errors; D006801:Humans; D007753:Laboratories / Q000592:standards*; D011786:Quality Control; D012016:Reference Values
Biological variation; Error limits; Quality control; Reference change value