History of Polymeric Gene Delivery Systems.
As an option for genetic disease treatment and an alternative for traditional cancer chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however, remains a main challenge in human gene therapy. Polymer-based delivery systems offer a safer and promising route for therapeutic gene delivery. Over the past five decades, various cationic polymers have been optimized for increasingly effective nucleic acid transfer. This resulted in a chemical evolution of cationic polymers from the first-generation polycations towards bioinspired multifunctional sequence-defined polymers and nanocomposites. With the increasing of knowledge in molecular biological processes and rapid progress of macromolecular chemistry, further improvement of polymeric nucleic acid delivery systems will provide effective tool for gene-based therapy in the near future.
Pharmaceutical Biotechnology, Center for System-Based Drug Research Ludwig-Maximilians-Universität, 81377, Munich, Germany. peng.zhang@cup.uni-muenchen.de.|Nanosystems Initiative Munich (NIM), 80799, Munich, Germany. peng.zhang@cup.uni-muenchen.de.
Peng
P
Zhang
Pharmaceutical Biotechnology, Center for System-Based Drug Research Ludwig-Maximilians-Universität, 81377, Munich, Germany.|Nanosystems Initiative Munich (NIM), 80799, Munich, Germany.|Center for NanoScience (CeNS), Ludwig-Maximilians-Universität, 80799, Munich, Germany.
Ernst
E
Wagner
D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D018014:Gene Transfer Techniques; D030342:Genetic Diseases, Inborn / Q000628:therapy; D015316:Genetic Therapy; D006801:Humans; D011108:Polymers / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D004337:Drug Carriers; D011108:Polymers; D012313:RNA; D004247:DNA
Gene delivery; Gene therapy; Polymeric gene delivery system; Polymers; Polyplexes; Transfection