Independent Association between Hyperuricemia and Histopathological Parameters in Chinese Patients with Henöch-Schönlein Purpura Nephritis.
BACKGROUND
This study aimed to investigate the role of hyperuricemia in the development of histopathological changes in HSPN.


METHODS
Clinical and laboratory data pertaining to 139 adult HSPN patients with and without elevated serum uric acid levels were retrospectively evaluated. There was a 14.4% prevalence of hyperuricemia in patients with HSPN.


RESULTS
Patients with hyperuricemia had higher levels of cystatin C and urine β2-microglobulin and lower levels of HDL-C in comparison to that in patients with normal serum uric acid levels (p < 0.05). Patients with hyperuricemia had higher scores of interstitial inflammation, tubular atrophy, interstitial fibrosis, glomerulosclerosis as compared to those normouricemic patients (p < 0.05). Serum uric acid was found to be correlated independently with the presence of interstitial inflammation, tubular atrophy, interstitial fibrosis, and glomerulosclerosis by multivariate analysis (p < 0.05).


CONCLUSIONS
High serum uric acid may be independently correlated with the development of tubulointerstitial lesions as well as glomerulosclerosis in HSPN.
Shan
S
Lu
Dong
D
Liu
Jing
J
Xiao
Genyang
G
Cheng
Xiaoyang
X
Wang
Xiaoxue
X
Zhang
Wenming
W
Yuan
Yanna
Y
Dou
Zhangsuo
Z
Liu
Zhanzheng
Z
Zhao
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D055316:Cystatin C / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D011695:IgA Vasculitis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000652:urine
D015415:Biomarkers; C525030:CST3 protein, human; D008076:Cholesterol, HDL; D055316:Cystatin C; D001613:beta 2-Microglobulin; D014527:Uric Acid