Diabetes mellitus may affect short-term outcome of Guillain-Barré syndrome.
We sought to determine influence of diabetes mellitus on Guillain-Barré syndrome (GBS) course and short-term prognosis. Among the 257 GBS patients included in this retrospective study, diabetes mellitus was present in 17%. The degree of disability at admission and on discharge was assessed according to the GBS Disability Scale (mild disability = 0-3, severe disability = 4-6). Even after correction for age, diabetes mellitus was significantly associated with more severe disability at nadir (odds ratio, OR = 3.4, p < 0.05) and on discharge (OR = 2.0, p < 0.05). Linear regression analysis with multiple factors included showed that age and presence of diabetes were significant predictors of severe disability at nadir (adjusted R2= 0.21, p < 0.05), and on discharge (adjusted R2= 0.19, p < 0.05). The presence of diabetes mellitus affects short-term prognosis of GBS, independent of age.
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Stojan
S
Peric
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Ivo
I
Bozovic
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Bogdan
B
Bjelica
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Ivana
I
Berisavac
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Olivera
O
Stojiljkovic
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Ivana
I
Basta
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Ljiljana
L
Beslac-Bumbasirevic
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Vidosava
V
Rakocevic-Stojanovic
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Dragana
D
Lavrnic
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Zorica
Z
Stevic
D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000503:physiopathology*; D004185:Disability Evaluation; D005260:Female; D020275:Guillain-Barre Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
Guillain-Barré syndrome; age; diabetes mellitus; disability; prognosis