Malaria treatment using novel nano-based drug delivery systems.
We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the most widely used drugs are the main reasons/drawbacks behind the failure in malarial therapy. Dose-related toxicity because of high doses is also a major concern. Therefore, to overcome these problems nano-based drug delivery systems are being developed to facilitate site-specific or target-based drug delivery and hence minimizing the development of resistance progress and dose-dependent toxicity issues. In this review, we discuss about the shortcomings in treating malaria and how nano-based drug delivery systems can help in curtailing the infectious disease malaria.
a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
Uday Krishna
UK
Baruah
a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
Kuppusamy
K
Gowthamarajan
a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
Ravisankar
R
Vanka
a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
Veera Venkata Satyanarayana Reddy
http://orcid.org/0000-0003-2057-3423
VVSR
Karri
a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
Kousalya
K
Selvaraj
a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
Gifty M
GM
Jojo
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D053758:Nanoparticles
D000962:Antimalarials
Infectious diseases; drug resistance; malaria; nanoparticles; site specific