Activity of urine arylsulfatase A in brain‑dead graft donors is a predictor of early and late graft function.
OBJECTIVE
Human lysosomal arylsulfatase A (ASA) is a member of the sulfatase family. Arylsulfatase A is required to degrade sulfatides. Sulfatides occur in the myelin sheets of the central and peripheral nervous system. In this study we evaluated the urine activity of lysosomal enzyme arylsulfatase A in brain‑dead donors as a marker and predictor of short - and long‑term renal allograft function.


METHODS
We analyzed data from kidney recipients who received organs from brain‑dead donors. Data from 40 donors and 68 recipients were analyzed.


RESULTS
Urine activity of arylsulfatase A in graft donors correlated positively with creatinine clearance in graft recipients after transplantation: significantly after 30 days (Rs=0.38, p=0.004) and after 3 years (Rs=0.38, p=0.03), and with borderline significance after 14 days (Rs=0.25, p=0.08) and after one year (Rs=0.23, p=0.07).


CONCLUSIONS
The results of this study suggest that arylsulfatase A has a protective effect on kidney allograft, and the urine activity of this enzyme in kidney donors correlates positively with graft function.
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Poland.
Ewa
E
Kwiatkowska
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Poland.
Leszek
L
Domanski
Department of Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Joanna
J
Bober
Department of Biochemistry, Pomeranian Medical University, Szczecin, Poland.
Krzysztof
K
Safranow
Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
Andrzej
A
Pawlik
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Poland.
Kazimierz
K
Ciechanowski
D000328:Adult; D015415:Biomarkers; D001921:Brain; D002553:Cerebroside-Sulfatase / Q000652:urine*; D003404:Creatinine; D006085:Graft Survival; D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation / Q000379:methods; D008875:Middle Aged; D009420:Nervous System; D066027:Transplant Recipients; D019737:Transplants
D015415:Biomarkers; D003404:Creatinine; D002553:Cerebroside-Sulfatase