Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10.
Phenotypic diversity between laboratory mouse strains provides a model for studying the underlying genetic mechanisms. The A/J strain performs poorly in various endurance exercise models. The aim of the study was to test if endurance capacity and contractility of the fast- and slow-twitch muscles are affected by the genes on mouse chromosome 10. The C57BL/6J (B6) strain and C57BL/6J-Chr 10A/J/NaJ (B6.A10) consomic strain which carries the A/J chromosome 10 on a B6 strain background were compared. The B6.A10 mice compared to B6 were larger in body weight (p< 0.02): 27.2 ± 1.9 vs. 23.8 ± 2.7 and 23.4 ± 1.9 vs. 22.9 ± 2.3 g, for males and females, respectively, and in male soleus weight (p< 0.02): 9.7 ± 0.4 vs. 8.6 ± 0.9 mg. In the forced running test the B6.A10 mice completed only 64% of the B6 covered distance (p< 0.0001). However, there was no difference in voluntary wheel running (p= 0.6) or in fatigability of isolated soleus (p= 0.24) or extensor digitorum longus (EDL,p= 0.7) muscles. We conclude that chromosome 10 of the A/J strain contributes to reduced endurance performance. We also discuss physiological mechanisms and methodological aspects relevant to interpretation of these findings.
Institute of Sport Science and Innovations, Lithuanian Sports University Kaunas, Lithuania.
Mindaugas
M
Kvedaras
Institute of Sport Science and Innovations, Lithuanian Sports University Kaunas, Lithuania.
Petras
P
Minderis
Institute of Sport Science and Innovations, Lithuanian Sports University Kaunas, Lithuania.
Andrej
A
Fokin
Institute of Sport Science and Innovations, Lithuanian Sports University Kaunas, Lithuania.
Aivaras
A
Ratkevicius
Institute of Sport Science and Innovations, Lithuanian Sports University Kaunas, Lithuania.
Tomas
T
Venckunas
School of Medicine, Medical Sciences and Nutrition, College of Life Sciences and Medicine, University of Aberdeen Aberdeen, UK.
Arimantas
A
Lionikas
chromosome substitution strains; electric stimulation; exercise; skeletal muscle; specific force