Influence of Left Ventricular Stroke Volume on Incident Heart Failure in a Population With Preserved Ejection Fraction (from the Strong Heart Study).
At a given level of left ventricular (LV) systolic function, LV pump performance (assessed by stroke index [SVi]) may differ, depending on LV size. We evaluated whether low SVi may be considered a marker of risk for incident congestive heart failure (HF), independent of LV geometry and systolic function, assessed by ejection fraction (EF) or midwall fractional shortening (MFS), in a large population-based sample with normal EF. Clinical and echocardiographic data from the second Strong Heart Study (SHS) examination, including 2,885 American Indians (59 ± 8 years; 63% women) with normal EF (EF ≥51% in men and EF ≥55% in women) and without prevalent HF or significant valve disease, were analyzed. Low SVi was defined as SVi ≤22 ml/m2.04. Low SVi was more common among men and associated with lower body mass index, systolic blood pressure, LV mass index, left atrial dimension, EF, and MFS and with higher relative wall thickness. During a mean 12-year follow-up, 209 participants developed HF and 246 had acute myocardial infarction. In Cox regression analysis, low SVi was associated with higher risk of incident HF (hazard ratio 1.38; 95% confidence interval 1.06 to 1.80), independently of age, gender, body mass index, heart rate, hypertension, prevalent cardiovascular disease, left atrial dimension index, LV mass index, LV concentric geometry, EF or MFS, and abnormal wall motion, also accounting for myocardial infarction as a competing risk event. In conclusion, in the SHS, low SVi was associated with higher incident rate of HF, independently of LV geometry and systolic function and other major confounders.
Hypertension Research Center, Federico II University, Naples, Italy; Department of Cardiology and Coronary Unit, Santa Maria delle Grazie Hospital of Pozzuoli, Naples, Italy.
Marina
M
De Marco
Hypertension Research Center, Federico II University, Naples, Italy; Department of Clinical Science, University of Bergen, Bergen, Norway.
Eva
E
Gerdts
Hypertension Research Center, Federico II University, Naples, Italy.
Costantino
C
Mancusi
Department of Medicine, Weill Cornell Medical College, New York, New York.
Mary J
MJ
Roman
Hypertension Research Center, Federico II University, Naples, Italy; Department of Clinical Science, University of Bergen, Bergen, Norway.
Mai Tone
MT
Lønnebakken
Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Elisa T
ET
Lee
Medstar Health Research Institute and Georgetown/Howard Universities Centers for Translational Sciences, Washington, DC.
Barbara V
BV
Howard
Department of Medicine, Weill Cornell Medical College, New York, New York.
Richard B
RB
Devereux
Hypertension Research Center, Federico II University, Naples, Italy; Department of Medicine, Weill Cornell Medical College, New York, New York; Department of Translational Medical Sciences, Federico II University, Naples, Italy. Electronic address: simogi@unina.it.
Giovanni
G
de Simone
D000368:Aged; D003920:Diabetes Mellitus / Q000453:epidemiology; D003952:Diagnostic Imaging; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D007198:Indians, North American; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D013318:Stroke Volume / Q000502:physiology; D014481:United States / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*