Global Molecular Epidemiology of IMP-Producing Enterobacteriaceae.
International data on the molecular epidemiology ofEnterobacteriaceaewith IMP carbapenemases are lacking. We performed short-read (Illumina) whole-genome sequencing on a global collection of 38 IMP-producing clinicalEnterobacteriaceae(2008 to 2014). IMP-producingEnterobacteriaceae(7 varieties within 11 class 1 integrons) were mainly present in the South Pacific and Asia. SpecificblaIMP-containing integrons (In809 withblaIMP-4, In722 withblaIMP-6, and In687 withblaIMP-14) were circulating among different bacteria in countries such as Australia, Japan, and Thailand. In1312 withblaIMP-1was present inKlebsiella pneumoniaefrom Japan andCitrobacter freundiifrom Brazil.Klebsiella pneumoniae(n= 22) was the most common species; clonal complex 14 (CC14) from Philippines and Japan was the most common clone and contained In1310 withblaIMP-26and In1321 withblaIMP-6TheEnterobacter cloacaecomplex (n= 9) consisted ofEnterobacter hormaecheiandE. cloacaecluster III. CC78 (from Taiwan) containing In73 withblaIMP-8was the most common clone among theE. cloacaecomplex. This study highlights the importance of surveillance programs using the latest molecular techniques for providing insight into the characteristics and global distribution ofEnterobacteriaceaewithblaIMPgenes.
Departments of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.|Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yasufumi
0000-0001-8595-8944
Y
Matsumura
Departments of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.|Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada.
Gisele
G
Peirano
Merck & Co., Inc., Rahway, New Jersey, USA.
Mary R
MR
Motyl
J. Craig Venter Institute, La Jolla, California, USA.
Mark D
MD
Adams
Public Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Liang
L
Chen
Public Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Barry
B
Kreiswirth
Departments of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
Rebekah
R
DeVinney
Departments of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada johann.pitout@cls.ab.ca.|Departments of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.|Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada.|Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
Johann D D
JD
Pitout
D001938:Brazil; D016971:Citrobacter freundii / Q000201:enzymology / Q000235:genetics; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics*; D007291:Inosine Monophosphate / Q000378:metabolism*; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D007291:Inosine Monophosphate; D001618:beta-Lactamases
Enterobacteriaceae; IMP; metallo-β-lactamases; molecular epidemiology