Does bacterial translocation influence the postoperative infections in splenectomized patients after abdominal trauma?
BACKGROUND
Some studies suggested that after abdominal trauma, postoperative infections are associated with bacterial translocation, whereas others have not replicated these findings. We have assessed the bacterial translocation and postoperative infections in patients undergoing splenectomy after abdominal trauma, using a very homogeneous study population.


METHODS
We consecutively studied, in a prospective observational clinical study, 125 patients who required urgent surgical treatment (splenectomy) following blunt abdominal trauma. For bacterial translocation identification, tissue samples were taken from liver, spleen and mesenteric lymph nodes (MLNs). Postoperative infectious complications in these patients were registered, confirmed by a positive culture obtained from the septic focus. Associations between clinical variables, bacterial translocation presence, and postoperative infection development were established.


RESULTS
Bacterial translocation was detected in 47 (37.6%) patients. Postoperative infections were present in 29 (23.2%) patients. A significant statistical difference was found between postoperative infections in patients with bacterial translocation evidence (22 of 47 patients: 46.8%) in comparison with patients without bacterial translocation (7 of 78 patients: 8.9%) (P < 0.05). After multivariate adjustment analysis: a) the bleeding ≥ 1500 mL was significantly associated with the risk of bacterial translocation and, b) bacterial translocation was significantly associated with the risk of postoperative infections. Bacterial strains isolated from infection sites were the same as those cultured in MLNs in 48.3% of the cases (n = 14 of 29).


CONCLUSIONS
There is higher risk of bacterial translocation in patients who required urgent surgical treatment (splenectomy) following blunt abdominal trauma and it is associated with a significant higher number of postoperative infections.
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Mario
M
Schietroma
Department of Surgery, University of L'Aquila, L'Aquila, Italy. Electronic address: pessiabeatrice87@gmail.com.
Beatrice
B
Pessia
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Sara
S
Colozzi
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Francesco
F
Carlei
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Gianfranco
G
Amicucci
D000007:Abdominal Injuries / Q000150:complications* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D018988:Bacterial Translocation; D005260:Female; D006801:Humans; D007239:Infections / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013156:Splenectomy / Q000009:adverse effects*; D013530:Surgical Wound Infection; D014949:Wounds, Nonpenetrating / Q000150:complications / Q000601:surgery; D055815:Young Adult
Bacterial translocation; Blunt abdominal trauma; Mesenteric lymph nodes; Postoperative infections; Splenectomy