AND logic-like pH- and light-dual controlled drug delivery by surface modified mesoporous silica nanoparticles.
Recently, the controlled drug delivery system has become a potential platform for biomedical application. Herein, we developed a pH and light-dual controlled cargo release system exhibiting AND logic based on MCM-41 mesoporous silica nanoparticles, which was surface modified using β-cyclodextrin (β-CD) with imine bond and azobenzene derivative. The complex of β-CD and azobenzene derivative effectively blocked the cargo delivery in pH=7.0 phosphate buffered saline (PBS) solution without 365nm UV light irradiation. The cargo was fully released when both factors of acidic environment (pH=5.0 PBS) and 365nm UV light irradiation were satisfied, meanwhile only very little cargo was delivered if one factor was satisfied. The result also demonstrates that the opening/closing of the gate and the release of the cargo in small portions can be controlled.
Key Laboratory of Resource Chemistry of Ministry of Education, Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, Shanghai Normal University, No. 100 Guilin Road, Shanghai 200234, China.
Junwei
J
Zhao
Key Laboratory of Resource Chemistry of Ministry of Education, Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, Shanghai Normal University, No. 100 Guilin Road, Shanghai 200234, China.
Zhaoshuai
Z
He
Key Laboratory of Resource Chemistry of Ministry of Education, Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, Shanghai Normal University, No. 100 Guilin Road, Shanghai 200234, China.
Biao
B
Li
Key Laboratory of Resource Chemistry of Ministry of Education, Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, Shanghai Normal University, No. 100 Guilin Road, Shanghai 200234, China. Electronic address: tycheng@shnu.edu.cn.
Tanyu
T
Cheng
Key Laboratory of Resource Chemistry of Ministry of Education, Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, Shanghai Normal University, No. 100 Guilin Road, Shanghai 200234, China.
Guohua
G
Liu
D000327:Adsorption; D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008027:Light; D008128:Logic; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D016062:Porosity; D053838:Scattering, Small Angle; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D014961:X-Ray Diffraction; D015027:Zebrafish
D003692:Delayed-Action Preparations; D012822:Silicon Dioxide; D009584:Nitrogen
Drug delivery; Mesoporous material; Nanoparticle; Photosensitive; pH-sensitive