A comparative study on oxidative stress role in nasal breathing impairment and obstructive sleep apnoea syndrome.
Obstructive sleep apnoea syndrome (OSAS) is a sleep disorder that leads to metabolic abnormalities and increased cardiovascular risk. This study aimed to define the expression and clinical significance of biomarkers involved in oxidative stress in patients with OSAS. A prospective study was designed to compare outcomes of oxidative stress laboratory tests in three groups of subjects. The study involved the recruitment of three groups of subjects, 10 patients with obstructive sleep apnoea syndrome with AHI > 30; 10 patients suffering from snoring at night with AHI < 15; 10 patients with nasal respiratory impairment with AHI < 5. Patients were subjected to skin prick tests for common aero-allergens, nasal endoscopy, active anterior rhinomanometry, fibrolaryngoscopy and polysomnography; and extra-routine diagnostic tests and procedures; analysis of oxidative and antioxidant (plasma thiol groups) biomarkers in blood and urine samples. No statistical differences in age, sex distribution or body mass index were present between the three groups (p > 0.05). There were significant differences in AHI among the three groups of patients (p < 0.05). No statistical significance was found in the Analysis of Variance (ANOVA) test (p > 0.05) between the levels of biomarkers of oxidative stress in the three populations studied. The results of our study show that the nose can play a role in the pathogenesis of OSAS through the production of biomarkers of oxidative stress.
Ospedale "Le Scotte", Department of Otolaryngology, University of Siena, Siena, Italy.
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Passali
Ospedale "Le Scotte", Department of Otolaryngology, University of Siena, Siena, Italy.
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Corallo
Ospedale "Le Scotte", Department of Otolaryngology, University of Siena, Siena, Italy.
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Petti
Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
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Longini
Department of Surgery, Institute of Clinical Otorhinolaryngology, "Tor Vergata University of Rome, Italy.
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Passali
Department of Paediatrics, University of Siena.
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Buonocore
Ospedale "Le Scotte", Department of Otolaryngology, University of Siena, Siena, Italy.
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Bellussi
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009666:Nose; D018384:Oxidative Stress; D011446:Prospective Studies; D012120:Respiration Disorders / Q000378:metabolism*; D020181:Sleep Apnea, Obstructive / Q000378:metabolism*; D012913:Snoring / Q000378:metabolism*
Biomarkers of oxidative stress; OSAS; Oxidative damage; Polysomnography