3D myocardial T1mapping using saturation recovery.
To propose a 3D quantitative high-resolution T1mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1phantom and in healthy subjects.



The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8 mm3. For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T1phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols.



There was good agreement between the T1values measured in a T1phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6 ± 31 msec vs. 1123.6 ± 8 msec, P = 0.9947). Mean and standard deviation of the myocardial T1values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881 ± 40 msec, 1181.3 ± 32 msec, and 1153.6 ± 28 msec respectively.



The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T1-mapping with T1values in good agreement with the 2D SASHA and improved precision.



2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:218-227.
Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.
Giovanna
G
Nordio
Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.
Markus
M
Henningsson
Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.
Amedeo
A
Chiribiri
Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.
Adriana D M
ADM
Villa
Philips Health Systems, London, UK.
Torben
T
Schneider
Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.|Wellcome Trust and EPSRC Medical Engineering Center, King's College London, UK.|BHF Centre of Excellence, King's College London, UK.|NIHR Biomedical Research Centre, King's College London.|Pontificia Universidad Católica de Chile, Escuela de Ingeniería, Santiago, Chile.
René M
RM
Botnar
D000328:Adult; D000465:Algorithms; D057791:Cardiac Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008954:Models, Biological; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
MRI; T1 mapping; accuracy; precision; saturation-recovery