Long-term clinical outcomes of patients with coronary chronic total occlusion treated with percutaneous coronary intervention versus medical therapy according to presence of diabetes mellitus.
OBJECTIVE
The aim of this study was to compare the long-term clinical outcomes of patients with chronic total occlusion (CTO) treated with percutaneous coronary intervention (PCI) versus medical therapy (MT) according to the presence of diabetes mellitus.


RESULTS
A total of 845 patients without diabetes and 702 patients with diabetes were included from the Samsung Medical Center CTO registry. The inverse probability of treatment weighting (IPTW) method was used to adjust for confounding factors. The primary outcome was cardiac death. Median follow-up duration was 46 (interquartile range: 23-71) months. Among the non-diabetes group, patients in the MT group had a higher rate of cardiac death (adjusted hazard ratio [HR] 2.54, 95% confidence interval [CI]: 1.19-5.42, p=0.02) compared to those in the PCI group. For patients with diabetes, there was no significant difference between the two groups in the rate of cardiac death (adjusted HR 1.09, 95% CI: 0.62-1.90, p=0.77). There was a significant interaction between diabetes and cardiac death (interaction p=0.03). After using IPTW methods, a similar result was observed (interaction p<0.001).


CONCLUSIONS
For the treatment of CTO, PCI may reduce the risk of cardiac mortality in non-diabetic patients but not in diabetic patients.
Division of Cardiology, Department of Medicine, Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Ki Hong
KH
Choi
Jeong Hoon
JH
Yang
Young Bin
YB
Song
Joo-Yong
JY
Hahn
Jin-Ho
JH
Choi
Hyeon-Cheol
HC
Gwon
Sang Hoon
SH
Lee
Seung-Hyuk
SH
Choi
D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography / Q000379:methods; D054059:Coronary Occlusion / Q000150:complications / Q000628:therapy*; D048909:Diabetes Complications / Q000401:mortality; D003920:Diabetes Mellitus / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000379:methods; D012042:Registries; D013995:Time; D016896:Treatment Outcome