Outcome of Biliary Atresia After Kasai's Portoenterostomy: A 15-year Experience.
BACKGROUND
To study the outcome of Biliary atresia after Kasai's portoenterostomy and clinical and biochemical factors affecting the outcome.


METHODS
Medical record review of patients of biliary atresia operated from January 2000 to December 2014. The following data were collected and analyzed - sex, age at surgery, liver function tests, associated congenital anomalies, and clearance of jaundice (at 3 months). Final outcome was classified as alive, dead, or jaundice-free at last follow-up (minimum 1 year).


RESULTS
121 patients (61.9% males) were included; 32 (26.5%) were lost to follow-up at 1 year. At last follow-up, out of the 89, 42 (47.2%) were alive, 29 (32.6%) were jaundice-free, and 47 (52.8%) had died. The native liver survival rate at last follow up was 43.8%. 42 (47.2%) patients had complete clearance of jaundice at 3 months post-procedure. Jaundice-clearance rate was significantly high in patients alive (83.3% vs 16.7%, P<0.001)) as compared to those who died later.


CONCLUSIONS
Jaundice clearance at 3 months post surgery is a good early indicator of long term success.
Department of Pediatric Surgery, Lilavati Hospital and Research Centre; and Department of Pediatric Surgery, Bai Jerbai Wadia Hospital for Children, Parel; Mumbai, India. Correspondence to: Dr Rajeev Redkar, 14, Buildarch Terrace, 1st Floor, Sitladevi Temple Road, Mahim, Mumbai 400 016, India. rajeev.redkar@gmail.com.
Rajeev
R
Redkar
Parag J
PJ
Karkera
Vinod
V
Raj
Anant
A
Bangar
Varun
V
Hathiramani
Janani
J
Krishnan
D001656:Biliary Atresia / Q000453:epidemiology* / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007565:Jaundice; D008297:Male; D011171:Portoenterostomy, Hepatic / Q000009:adverse effects / Q000401:mortality / Q000706:statistics & numerical data*; D011183:Postoperative Complications