Association Between Serum Free Fatty Acids Levels and Gestational Diabetes Mellitus: a Cross-Sectional Study.
BACKGROUND
This study aimed to assess the relationship between serum free fatty acid (FFA) levels and gestational diabetes mellitus (GDM) in Chinese pregnant women.


METHODS
A cross-sectional study was performed among 779 eligible pregnant women who underwent detailed prenatal visits in Hangzhou, China.


RESULTS
Patients with GDM had significantly higher serum FFA levels than those without GDM. Spearman's correlation analysis showed that FFA levels were positively correlated with fasting plasma glucose, 1hPG, 2hPG, HOMA-IR, triglyceride, and sialic acid (p < 0.05) and negatively correlated with serum amylase level (all with p < 0.05). Stepwise logistic regression analysis further showed that elevated FFA levels significantly contributed to the risk for GDM.


CONCLUSIONS
Our findings suggested that serum FFA levels were significantly associated with GDM.
Juanwen
J
Zhang
Jinmei
J
Yao
Ying
Y
Zhao
Nengneng
N
Zheng
Yuying
Y
Dai
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D005215:Fasting / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D016015:Logistic Models; D011247:Pregnancy; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified