Four New Xanthones from Cratoxylum cochinchinense and Their In Vitro Antiproliferative Effects.
The study of the chemical constituents of branches and twigs ofCratoxylum cochinchinensecollected in Singapore led to the isolation and structural elucidation of four new xanthones, named cratoxanthone A (1), B (2), C (3), and D (4), together with six known xanthones (5-10) and one known dihydroanthracenone (11). Eight xanthones (including1and2) and11were tested for their antiproliferative activity in three human carcinoma cell lines (lung adenocarcinoma A549, colorectal carcinoma Colo205, and epidermoid carcinoma KB) and a human acute lymphoblastic leukemia B cell line (NALM-6), and the mitochondrial membrane potential was determined in KB cells. New xanthones1and2attenuated NALM-6 cell proliferation with IC50values of 17.78 and 8.27 µM, respectively. Furthermore, KB cells treated with these compounds had significantly decreased mitochondrial membrane potentials. Notably, the proliferation of A549 cells was specifically inhibited by11, but not the xanthones.
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Chihiro
C
Ito
Faculty of Pharmacy, Meijo University, Nagoya, Japan.|Department of Physiology, Aichi Medical University, Nagakute, Japan.
Takuya
T
Matsui
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Ai
A
Niimi
Department of Botany, National University of Singapore, Singapore, Singapore.
Hugh T-W
HT
Tan
School of Sport and Health Science, Tokai Gakuen University, Miyoshi, Japan.
Masataka
M
Itoigawa
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D028084:Clusiaceae / Q000737:chemistry*; D006801:Humans; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018520:Plant Shoots / Q000737:chemistry; D012846:Singapore; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D044004:Xanthones