Seeing HPV in the New Light Offers a Glimpse of Heparin.
In this issue of Structure, Guan et al. (2017) describe cryo-EM mapping of human papillomavirus 16 (HPV16) capsids that propose locations for L2 and heparin binding sites. The high resolution of the modern cryo-EM methods (in this case down to 4.3 Å) opens great opportunities to probe conformational changes that take place during virus-receptor binding.
Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Morrison Research Center, Lincoln, NE 68583, USA. Electronic address: pangeletti2@unl.edu.
Peter C
PC
Angeletti
D002213:Capsid; D036022:Capsid Proteins; D006493:Heparin; D052162:Human papillomavirus 16; D006801:Humans; D009856:Oncogene Proteins, Viral
D036022:Capsid Proteins; D009856:Oncogene Proteins, Viral; D006493:Heparin