Enantioselective Synthesis of Cephalimysins B and C.
The first synthesis of cephalimysins B and C is reported. The route features a Ni(II)-diamine-catalyzed enantioselective conjugate addition of a densely substituted 3(2H)-furanone and an efficient dihydroxylation-lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation.
Department of Chemistry, Masaryk University , Brno, 625 00, Czech Republic.
David
D
Chalupa
Department of Chemistry, Masaryk University , Brno, 625 00, Czech Republic.
Petra
P
Vojáčková
Department of Chemistry, Masaryk University , Brno, 625 00, Czech Republic.
Jiří
J
Partl
Department of Chemistry, Masaryk University , Brno, 625 00, Czech Republic.|International Clinical Research Center, St. Anne's University Hospital , Brno, 656 91, Czech Republic.
Dražen
D
Pavlović
Department of Chemistry, Masaryk University , Brno, 625 00, Czech Republic.
Marek
M
Nečas
Department of Chemistry, Masaryk University , Brno, 625 00, Czech Republic.|International Clinical Research Center, St. Anne's University Hospital , Brno, 656 91, Czech Republic.
Jakub
0000-0001-9232-3218
J
Švenda