Troponin T levels associated with genetic variants in NOTCH2 and MTNR1B in women with psychosis.
Psychosis patients have increased prevalence of metabolic disorders, which increase the risk for cardiovascular disease. Elevated troponin T level is an early biomarker of cardiovascular damage. We tested for association between troponin T levels and genetic risk variants of elevated blood glucose level in psychosis. Glucose and troponin T levels correlated positively. MTNR1B rs10830963 and NOTCH2 rs10923931 associated with troponin T levels in women, adjusted for glucose levels. These findings may indicate metabolic genetic influences on troponin T levels among women with psychosis.
Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Adult Psychiatry, PRIMA Barn och Vuxenpsykiatri AB, Stockholm, Sweden. Electronic address: dzana.hukic@ki.se.
Dzana Sudic
DS
Hukic
Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Catharina
C
Lavebratt
Department of Adult Psychiatry, PRIMA Barn och Vuxenpsykiatri AB, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Eric
E
Olsson
Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery; Karolinska Institutet, Stockholm, Sweden.
Claes-Göran
CG
Östenson
Department of Clinical Sciences, Karolinska Institutet, Danderyd University; Hospital, Stockholm, Sweden.
Sven V
SV
Eriksson
Department of Clinical Sciences, Lund University, Lund, Sweden.
David
D
Erlinge
Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Martin
M
Schalling
Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Adult Psychiatry, PRIMA Barn och Vuxenpsykiatri AB, Stockholm, Sweden; Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Urban
U
Ösby
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011618:Psychotic Disorders / Q000097:blood* / Q000235:genetics*; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D051883:Receptor, Notch2 / Q000235:genetics*; D012307:Risk Factors; D020107:Troponin T / Q000097:blood*
D001786:Blood Glucose; C573871:MTNR1B protein, human; C497764:NOTCH2 protein, human; D044123:Receptor, Melatonin, MT2; D051883:Receptor, Notch2; D020107:Troponin T; D005947:Glucose
Cardiovascular biomarker; Schizophrenia; Type 2 diabetes