The Fungal Mycobiome and Its Interaction with Gut Bacteria in the Host.
The advent of sequencing technology has endowed us with the capacity to study microbes constituting the human commensal community that were previously non-culturable. Much of the initial works have concentrated on the bacterial flora constituting the gut microbiome, since specimens are readily accessible in health and disease. Less, however, is understood of the "silent population"-the fungal species, also known as the mycobiome. Living in symbiosis with bacteria as commensals in our body, it is perceivable that the mycobiome exerts an inadvertent influence on the microbiome. We review here the recent knowledge gained from study of the interaction between the mycobiome and microbiome in health and disease susceptibility, immunity, and consequences from antimicrobial treatment.
Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore 119228, Singapore. qi_hui_sam@nuhs.edu.sg.
Qi Hui
QH
Sam
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore. bchcmw@nus.edu.sg.|NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. bchcmw@nus.edu.sg.
Matthew Wook
MW
Chang
Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore 119228, Singapore. chailouis@hotmail.com.|Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 11, 1E Kent Ridge Road, Singapore 119228, Singapore. chailouis@hotmail.com.
Louis Yi Ann
LY
Chai
D000818:Animals; D000898:Antibiosis; D001419:Bacteria; D004032:Diet; D004198:Disease Susceptibility; D005658:Fungi; D000069196:Gastrointestinal Microbiome; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007109:Immunity; D056265:Microbial Interactions; D000072761:Mycobiome; D009765:Obesity / Q000209:etiology
fungus; gastrointestinal; gut microbiome; microflora; mycobiome; pathobiont