A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba.
A new benzylisoquinoline alkaloid (•)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).
a Basic Medical College of Southwest Medical University , Luzhou 646100 , China.
Bin
B
Tang
a Basic Medical College of Southwest Medical University , Luzhou 646100 , China.
Hua
H
Tu
a Basic Medical College of Southwest Medical University , Luzhou 646100 , China.
Han-An
HA
Long
a Basic Medical College of Southwest Medical University , Luzhou 646100 , China.
Jun
J
Du
a Basic Medical College of Southwest Medical University , Luzhou 646100 , China.
Jian-Min
JM
Guo
b First Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China.
Hong-Jin
HJ
Liu
c Second Affiliated Hospital of Southwest Medical University , Luzhou 646100 , China.
Xin
X
Hu
d College of Chemistry and Chemical Engineering , Yibin University , Yibin 644007 , China.
Li
L
Yang
a Basic Medical College of Southwest Medical University , Luzhou 646100 , China.
Xi
X
Du
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044182:Benzylisoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D032862:Litsea / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines; C000622605:N-methoxycarbonyl-norjuziphine; C438020:norjuziphine; D002945:Cisplatin
Lauraceae; Litsea cubeba; X-ray diffraction; benzylisoquinoline; cytotoxicity