Protective Effects of Genipin on Gastrointestinal Disorders.
Genipin, an aglycone of geniposide, is a major component of gardeniae fructus, and has been used to treat jaundice, various inflammatory disorders, and liver disease, and has also been used as a natural cross-linking agent. The authors conducted several experiments to evaluate the protective effects of genipin on gastrointestinal disorders, such as, gastritis and gastric ulcers. Genipin showed inhibitory effects against HCl·ethanol-induced acute gastritis and indomethacin-induced gastric ulcers in rats and increased prostaglandin E2(PGE2) in AGS gastric cancer cell. Genipin had significant effects on aggressive factors, acid-neutralization, and gastric secretion, and inhibited H+/K+-ATPase (a proton pump), which secretes gastric acid. The results obtained indicate that genipin has significant gastroprotective effects and might be useful for treating and preventing gastric lesions.
College of Pharmacy, Duksung Women's University.
Yoon Ah
YA
Sohn
In Young
IY
Hwang
Sun Yi
SY
Lee
Hyo Sun
HS
Cho
Choon Sik
CS
Jeong
D000818:Animals; D045744:Cell Line, Tumor; D005765:Gastrointestinal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D039823:Iridoids / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
D005765:Gastrointestinal Agents; D039823:Iridoids; D020011:Protective Agents; C007834:genipin