Fifty Years of Research in ARDS. Insight into Acute Respiratory Distress Syndrome. From Models to Patients.
Clinicians who treat patients with acute respiratory distress syndrome (ARDS) use information and guidance from a wide array of sources, ranging from laboratory experiments, clinical data, health services research, intuition, to personal experience. Each of these sources of information brings unique methodology and information, but each is inherently limited. Because ARDS is a syndrome (and not a disease), the clinician or scientist must take additional care when applying knowledge to individual patients among a group, because patients often do not have identical lung pathophysiology. However, an overwhelming body of knowledge has accumulated in the field from multiple sources. In this review, we describe the nature of some of these sources as they relate to ARDS and review examples of when they have succeeded (and sometimes failed) in shaping practice or advancing knowledge about ARDS.
1 Department of Anesthesia.|2 Department of Critical Care Medicine, and.|3 Keenan Centre for Biomedical Research, St. Michael's Hospital, Toronto, Ontario, Canada.|4 Interdepartmental Division of Critical Care Medicine.|5 Department of Anesthesia, and.|6 Department of Physiology, University of Toronto, Toronto, Ontario, Canada; and.
John G
0000-0002-1246-9573
JG
Laffey
4 Interdepartmental Division of Critical Care Medicine.|5 Department of Anesthesia, and.|6 Department of Physiology, University of Toronto, Toronto, Ontario, Canada; and.|7 Department of Critical Care Medicine.|8 Department of Anesthesia, and.|9 The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Brian P
BP
Kavanagh
D035843:Biomedical Research; D006801:Humans; D008954:Models, Biological; D012107:Research Design; D012128:Respiratory Distress Syndrome / Q000628:therapy*
acute lung injury; case series; clinical trial; cohort study; experimental model