Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery.
Hydrogels formed by the self-assembly of low-molecular-weight gelators (LMWGs) are promising scaffolds for drug-delivery applications. A new biocompatible hydrogel, resulting from the self-assembly of nucleotide-lipid salts can be safely injected in vivo. The resulting hydrogel provides sustained-release of protein for more than a week.
ARNA Laboratory, Inserm, U1212, CNRS 5320, Université de Bordeaux, F-33000, Bordeaux, France.
Michael A
MA
Ramin
Inserm, U1026, Université de Bordeaux, F-33000, Bordeaux, France.
Kotagudda Ranganath
KR
Sindhu
ARNA Laboratory, Inserm, U1212, CNRS 5320, Université de Bordeaux, F-33000, Bordeaux, France.
Ananda
A
Appavoo
ARNA Laboratory, Inserm, U1212, CNRS 5320, Université de Bordeaux, F-33000, Bordeaux, France.
Khalid
K
Oumzil
Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA.
Mark W
MW
Grinstaff
Inserm, U1026, Université de Bordeaux, F-33000, Bordeaux, France.
Olivier
O
Chassande
ARNA Laboratory, Inserm, U1212, CNRS 5320, Université de Bordeaux, F-33000, Bordeaux, France.
Philippe
P
Barthélémy
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002412:Cations / Q000737:chemistry*; D002417:Cattle; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000493:pharmacokinetics; D020100:Hydrogels / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D046529:Microscopy, Electron, Transmission; D012212:Rheology; D012492:Salts / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000493:pharmacokinetics; D055672:Static Electricity; D065566:Subcutaneous Absorption
D001672:Biocompatible Materials; D002412:Cations; D005456:Fluorescent Dyes; D020100:Hydrogels; D008055:Lipids; D012492:Salts; D012710:Serum Albumin, Bovine
amphiphiles; drug delivery; hydrogels; low-molecular-weight gels; supramolecular assemblies; sustained release