Poroid Condyloma Versus Poroma With Atypias Because of Human Papillomavirus Infection.
We present the case of a 43-year-old white man with a complex lesion at the base of the penis that combines features of both a poroma and a condyloma with human papillomavirus (HPV) infection, atypias, and focal ductal differentiation. It was a papillomatous lesion with epidermal hyperplasia, which mainly contained focally pigmented monotonous basaloid cells. Ductal lumina with cuticular cells were easily identified. Atypias were focally evidenced, with nuclear enlargement and hyperchromasia. Hypergranulosis and koilocytosis were also present. Immunohistochemical studies indicated p16 and p53 immunoexpression in the areas with cellular atypia and koilocytosis. Studies with in situ hybridization showed positivity for HPVs 16/18 and 31/33 in such areas, with a high rate of proliferation indicated by Ki-67. There was no positivity for HPV 6/11. Epithelial membrane antigen highlighted the ductal lumina, whereas there was no immunostaining for carcinoembryonic antigen.
*Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain †Department of Pathology, Southern California Kaiser Permanente, Los Angeles Medical Center (LAMC), Los Angeles, CA.
Angel
A
Fernandez-Flores
David S
DS
Cassarino
D000328:Adult; D003218:Condylomata Acuminata / Q000150:complications* / Q000378:metabolism / Q000821:virology; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications* / Q000378:metabolism; D010409:Penile Diseases / Q000150:complications* / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53