Vitamin D status is not related to insulin resistance in different phenotypes of moderate obesity.
Low plasma 25-hydroxy-vitamin D (25OHD) and high levels of parathyroid hormone (PTH) are associated with obesity and could play a role in the occurrence of complications such as insulin resistance. The objective of the study was to evaluate whether the relationship between 25OHD status and phosphocalcic parameters differs between metabolically healthy obese (MHO) and insulin-resistant obese (IRO). This cross-sectional study included 158 consecutive adults (121 females) with obesity (body mass index (BMI) 35.15 ± 2.8 kg/m2), aged 43.21 ± 13.6 years. Serum 25OHD, calcemia, phosphatemia, PTH, plasma lipids, fasting plasma glucose, insulin levels, and body composition were measured. Participants were classified as MHO (n = 65) or IRO (n = 93) based on homeostatic model assessment insulin-resistance value. IRO patients had a higher BMI (p = 0.001), waist circumference (p = 0.03), and trunk fat mass (p = 0.007) than MHO patients. Mean HbA1c (p = 0.03), triglycerides (p = 0.02), and hsCRP (p = 0.04) plasmatic levels were increased in the IRO group. No between-group difference was found on 25OHD, PTH, calcium, or phosphorus plasmatic levels. Only age-predicted 25OHD levels were identified among IRO participants, whereas no factors were identified in MHO. No predictive factors of PTH plasmatic level were identified in the IRO and MHO groups. Although MHO and IRO patients have different metabolic profiles, we did not detect any difference regarding either 25OHD or PTH. Insulin resistance was not a predictive factor of vitamin D status. Our results confirm the absence of link between vitamin D status and insulin resistance in moderate obesity.
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.
Manal
M
Al Masri
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.
Ahmed Jerome
AJ
Romain
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.
Catherine
C
Boegner
b Département de Médecine Nucléaire, CHRU Montpellier, Montpellier, France.|c U1046 INSERM, UMR9214 CNRS, Physiologie et Médecine Expérimentale du Cœur et des Muscles, University of Montpellier, CHRU Montpellier, France.
Laurent
L
Maimoun
b Département de Médecine Nucléaire, CHRU Montpellier, Montpellier, France.
Denis
D
Mariano-Goulart
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.
Vincent
V
Attalin
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.
Elodie
E
Leprieur
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.
Marion
M
Picandet
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.|c U1046 INSERM, UMR9214 CNRS, Physiologie et Médecine Expérimentale du Cœur et des Muscles, University of Montpellier, CHRU Montpellier, France.
Antoine
A
Avignon
a Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHRU Montpellier, Montpellier, France.|c U1046 INSERM, UMR9214 CNRS, Physiologie et Médecine Expérimentale du Cœur et des Muscles, University of Montpellier, CHRU Montpellier, France.
Ariane
A
Sultan
D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D050154:Adiposity; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D000067329:Obesity, Metabolically Benign / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood; D011236:Prediabetic State / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D015995:Prevalence; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*
D015415:Biomarkers; C470125:PTH protein, human; D010281:Parathyroid Hormone; D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol
body composition; composition corporelle; insulin resistance; insulinorésistance; metabolism; métabolisme; obesity; obésité