Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review.
We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension. More well-designed, prospective studies are needed to determine the optimal treatment strategy.
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.|Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
Kathelijne
K
Kraal
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Thomas
T
Blom
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Max
M
van Noesel
Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
Leontien
L
Kremer
Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
Huib
H
Caron
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.|Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
Godelieve
G
Tytgat
Department of Medical Oncology, Academic Medical Centre (AMC), Amsterdam, The Netherlands.
Heleen
H
van der Pal
D006801:Humans; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D013117:Spinal Cord Compression / Q000209:etiology / Q000628:therapy
intraspinal extension; late effects; long-term health problems; neuroblastoma; spinal cord compression; systematic review