Complementary role of the Memorial Sloan Kettering Cancer Center nomogram to the American Joint Committee on Cancer system for the prediction of relapse of major salivary gland carcinoma after surgery.
The purpose of this study was to test the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram in predicting recurrence risk of major salivary gland carcinoma in an Asian cohort.



We retrospectively enrolled 149 patients who had undergone intended curative resections for major salivary gland carcinoma between 2007 and 2012. The performance of the MSKCC nomogram and the American Joint Committee on Cancer (AJCC) seventh staging system in predicting recurrence risk was compared.



The MSKCC nomogram and the AJCC staging system both accurately predicted the 5-year recurrence probabilities, with the concordance index (c-index = 0.82; 95% confidence interval [CI], 0.75-0.89 vs c-index, 0.77; 95% CI, 0.68-0.87; p = .45) in patients with major salivary gland carcinomas after curative surgeries. Comparing to the actual observed events, the calibration plot indicated that the MSKCC nomogram accurately estimated the recurrence in low-risk groups but tended to overestimate in high-risk groups. When using the MSKCC nomogram to predict the 5-year recurrence-free probability in each AJCC stage, the prediction was very good for patients with AJCC stages I and II disease (c-index = 0.92 and 0.90, respectively) and modest for those of AJCC stages III and IVa (c-index = 0.51 and 0.62, respectively).



The MSKCC nomogram and the AJCC staging system each had its value in predicting recurrence of major salivary gland cancers. When using the MSKCC nomogram to predict the 5-year recurrence-free probability in each AJCC stage, the MSKCC nomogram was more accurate in predicting recurrence risks in those patients with AJCC stage I and II diseases than those with late-stage diseases. © 2017 Wiley Periodicals, Inc. Head Neck 39: 860-867, 2017.
Department of Medical Oncology, Chang Gung Memorial Hospital at LinKou, Tao-Yuan, Taiwan, Republic of China.|Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan, Republic of China.
Wen-Chi
WC
Chou
Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital at LinKou, Tao-Yuan, Taiwan, Republic of China.
Kai-Ping
0000-0003-1777-9578
KP
Chang
Department of Medical Oncology, Chang Gung Memorial Hospital at Chiayi, Taipei, Taiwan, Republic of China.
Chang-Hsien
CH
Lu
Department of Radiation Oncology, Chang Gung Memorial Hospital at Chiayi, Taiwan, Republic of China.
Miao-Fen
MF
Chen
Department of Radiology, Chang Gung Memorial Hospital at Kaoshiung, Taiwan, Republic of China.
Yu-Fan
YF
Cheng
Department of Medical Oncology, Chang Gung Memorial Hospital at Keelung, Taiwan, Republic of China.
Kun-Yun
KY
Yeh
Department of Medical Oncology, Chang Gung Memorial Hospital at Keelung, Taiwan, Republic of China.
Cheng-Hsu
CH
Wang
Department of Medical Oncology, Chang Gung Memorial Hospital at LinKou, Tao-Yuan, Taiwan, Republic of China.
Yung-Chang
YC
Lin
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan, Republic of China.|Department of Surgery, Chang Gung Memorial Hospital at LinKou, Tao-Yuan, Taiwan, Republic of China.
Ta-Sen
TS
Yeh
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D009367:Neoplasm Staging; D049451:Nomograms; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000601:surgery*; D055815:Young Adult
American Joint Committee on Cancer (AJCC) system; major salivary gland carcinoma; nomogram; relapse-free survival; validation