Effect of neostigmine on contractility of equine pre-ovulatory follicles: An in vitro study.
In this study, the Authors investigated the modulatory effect of three single doses (10-6, 10-5, and 10-4M) of neostigmine on the spontaneous contractility of equine pre-ovulatory follicles in an isolated organ bath, to establish the relationship between this acetylcholinesterase inhibitor and ovulation, in the mare. The results indicate that neostigmine increases pre-ovulatory contractility in equine follicles at each dose, but in a different manner. Indeed, the rise in contractility induced by neostigmine at 10-6M and 10-4M was phasic, while at 10-5M it was tonic. The data obtained indicate possible implications of these drugs in the pharmacological modulation of equine ovulation.
Department of Emergency and Organ Transplantation, Section of Veterinary Medicine and Animal Production, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.
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Piccinno
Department of Emergency and Organ Transplantation, Section of Veterinary Medicine and Animal Production, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.
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Rizzo
ASL, Specialist Agreement, Siav, Putignano, Bari, Italy.
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Cariello
Department of Emergency and Organ Transplantation, Section of Veterinary Medicine and Animal Production, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy. Electronic address: raffaeleluigi.sciorsci@uniba.it.
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Sciorsci
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006736:Horses / Q000502:physiology*; D066298:In Vitro Techniques; D009388:Neostigmine / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects* / Q000502:physiology; D011374:Progesterone / Q000097:blood
D009388:Neostigmine; D011374:Progesterone
Contractility; Mare; Neostigmine; Pre-ovulatory follicles