Tuning Chromosomal Instability to Optimize Tumor Fitness.
Low rates of chromosomal instability (CIN) are weakly tumor promoting, whereas high rates of CIN cause cell death and tumor suppression. In this context, Sansregret and colleagues show that one mechanism to restrain excessive CIN in tumor cells and increase fitness is through mutations in the anaphase promoting complex/cyclosome. This serves to delay mitotic progression and decrease the rate of chromosome missegregation. Cancer Discov; 7(2); 134-6. ©2017 AACRSee related article by Sansregret et al., p. 218.
Department of Medicine Hematology/Oncology, University of Wisconsin-Madison, Madison, Wisconsin.|UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Mark E
ME
Burkard
UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin. baweaver@wisc.edu.|Departments of Cell and Regenerative Biology and Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Beth A
BA
Weaver
D064173:Anaphase-Promoting Complex-Cyclosome / Q000235:genetics; D016923:Cell Death; D045744:Cell Line, Tumor; D043171:Chromosomal Instability; D006801:Humans
D064173:Anaphase-Promoting Complex-Cyclosome