Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective.
Human papillomavirus (HPV) associated head and neck squamous cell carcinomas (HNSCCs), have become a serious global health problem. Despite decreases in HPV-negative HNSCCs, the prevalence of HPV-positive HNSCCs has significantly increased. HPV-positive cancers are associated with superior survival outcomes when compared to HPV-negative cancers, which appears likely to be associated with differences in the molecular pathogenesis of the two diseases. While therapies are still problematic, the current HPV vaccine programs hold a promise for the primary prevention of HPV-related HNSCCs and since Australia was the first to introduce a nationwide HPV vaccine program, it is in a unique position to observe the effects of the vaccine on HNSCCs. This review discusses the epidemiological trends associated with HPV in HNSCC, with reference to the differences between HPV-positive and HPV-negative HNSCCs and the prevention potential of HPV vaccines.
School of Biomedical Sciences, Curtin University, Building 308, Kent Street, Bentley, Perth, WA, 6102, Australia.
Marwah Abbas Hassan
MAH
Aldalwg
School of Biomedical Sciences, Curtin University, Building 308, Kent Street, Bentley, Perth, WA, 6102, Australia. b.brestovac@curtin.edu.au.
Brian
http://orcid.org/0000-0003-4501-2649
B
Brestovac
D001315:Australia / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control / Q000821:virology*; D006258:Head and Neck Neoplasms / Q000517:prevention & control / Q000821:virology*; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D053918:Papillomavirus Vaccines; D000077195:Squamous Cell Carcinoma of Head and Neck
D053918:Papillomavirus Vaccines
Head and neck squamous cell carcinoma; Human papillomavirus; Oropharyngeal squamous cell carcinoma; Vaccine