A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB).
One new chromone derivative, (2'S*)-2-(2'-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound 2 and 3 possessed significant inhibitory activity against α-glucosidase with IC50values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively.
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Huarong
H
Huang
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Ting
T
Liu
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Xiaoen
X
Wu
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Junxi
J
Guo
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Xiong
X
Lan
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Qin
Q
Zhu
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Xi
X
Zheng
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Kun
K
Zhang
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002867:Chromones / Q000737:chemistry* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D043803:Phenalenes / Q000737:chemistry / Q000494:pharmacology; D053833:Wetlands; D000520:alpha-Glucosidases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002867:Chromones; D065089:Glycoside Hydrolase Inhibitors; D043803:Phenalenes; D000520:alpha-Glucosidases
Chromone derivative; Penicillium sp; antibacterial activity; mangrove-derived fungus; α-glucosidase inhibition