Elevated Presepsin Levels are Associated with Severity and Prognosis of Severe Acute Pancreatitis.
BACKGROUND
Current clinical scoring systems are insufficient in the early identification of severe acute pancreatitis (SAP) patients at risk of developing potentially lethal complications. This present study was designed to evaluate the relationship of presepsin with disease severity, local complications, organ failure, and mortality of SAP.


METHODS
Eighty-five SAP patients and 85 gender- and age-matched healthy volunteers were enrolled. Presepsin concentrations were measured on admission from SAP patients and at study entry from healthy individuals.


RESULTS
Presepsin levels were obviously higher in patients than in healthy individuals (1078.35 ± 385.16 pg/mL vs. 95.23 ± 21.64 pg/mL). Presepsin was identified as an independent predictor of local complications, organ failure, and in-hospital mortality and was positively associated with traditional predictors including the Bedside Index for Severity in Acute Pancreatitis (BISAP), Acute Physiology and Chronic Health Care Evaluation II (APACHE-II), Ransom score, and computed tomography severity index (CTSI).With the receiver operating characteristic (ROC) analysis, presepsin predicted local complications, organ failure, and in-hospital mortality of SAP patients with high areas under receiver operating characteristic curve and its predictive value was similar to the traditional predictors that are currently used in clinical practice.


CONCLUSIONS
Increased presepsin level was found to be an accurate predictor of disease severity and identified as a novel prognostic marker of local complications, organ failure, and mortality of SAP.
Jianbo
J
Lin
Zhe
Z
Li
Yanhong
Y
Zheng
Yang
Y
Zhang
Cunhua
C
Shao
Gongpan
G
Liu
Jiangong
J
Li
D018806:APACHE; D000208:Acute Disease; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology; D010195:Pancreatitis / Q000097:blood* / Q000150:complications / Q000401:mortality*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index
D015415:Biomarkers; D018950:Lipopolysaccharide Receptors; D010446:Peptide Fragments; C000594167:presepsin protein, human