New advances in restricted access materials for sample preparation: A review.
The determination of organic and inorganic analytes from biological samples need efficient sample preparation procedures in order to capture the analyte in a media with many macromolecules, which can cause analytical errors and problems with the instruments. Thus, "intelligent" sorbents, called restricted access materials (RAMs), have been widely used with these samples, due to their ability to retain analytes and exclude macromolecules. These materials have been obtained by modifying the external surfaces of conventional sorbents (e.g. polymers, carbon nanotubes, active carbon, and silica-based materials) with hydrophilic groups (chemical barrier), as well as by the presence of small pores (physical barrier) accessible only to low molecular weight molecules. Supramolecular solvents (SUPRAs) have also been used as RAMs, due to their abilities to exclude proteins according to size or through precipitation with the solvents. Therefore, due to the relevance of these materials, this review presents an overview of the most recent advances in obtaining RAMs based on silica, polymers, carbon nanotubes, (activated) carbon, and solvents, as well as their applications in biological sample preparation.
Laboratory of Toxicant and Drug Analysis, Gabriel Monteiro da Silva St. 700, Federal University of Alfenas - Unifal-MG, 37130-000, Alfenas, MG, Brazil.
Henrique Dipe
HD
de Faria
Laboratory of Toxicant and Drug Analysis, Gabriel Monteiro da Silva St. 700, Federal University of Alfenas - Unifal-MG, 37130-000, Alfenas, MG, Brazil.
Lailah Cristina de Carvalho
LC
Abrão
Laboratory of Toxicant and Drug Analysis, Gabriel Monteiro da Silva St. 700, Federal University of Alfenas - Unifal-MG, 37130-000, Alfenas, MG, Brazil.
Mariane Gonçalves
MG
Santos
Laboratory of Toxicant and Drug Analysis, Gabriel Monteiro da Silva St. 700, Federal University of Alfenas - Unifal-MG, 37130-000, Alfenas, MG, Brazil.
Adriano Francisco
AF
Barbosa
Laboratory of Toxicant and Drug Analysis, Gabriel Monteiro da Silva St. 700, Federal University of Alfenas - Unifal-MG, 37130-000, Alfenas, MG, Brazil. Electronic address: eduardocfig@yahoo.com.br.
Eduardo Costa
EC
Figueiredo
D002606:Charcoal; D057927:Hydrophobic and Hydrophilic Interactions; D046911:Macromolecular Substances; D037742:Nanotubes, Carbon; D011108:Polymers; D012822:Silicon Dioxide; D012997:Solvents; D013048:Specimen Handling / Q000379:methods*
D046911:Macromolecular Substances; D037742:Nanotubes, Carbon; D011108:Polymers; D012997:Solvents; D002606:Charcoal; D012822:Silicon Dioxide
Protein exclusion; Restricted access carbon nanotubes; Restricted access materials; Restricted access molecularly imprinted polymers; Restricted access-activated carbon cloths; Sample preparation; Supramolecular solvents