Emerging pathogens in the fish farming industry and sequencing-based pathogen discovery.
The use of large scale DNA/RNA sequencing has become an integral part of biomedical research. Reduced sequencing costs and the availability of efficient computational resources has led to a revolution in how problems concerning genomics and transcriptomics are addressed. Sequencing-based pathogen discovery represents one example of how genetic data can now be used in ways that were previously considered infeasible. Emerging pathogens affect both human and animal health due to a multitude of factors, including globalization, a shifting environment and an increasing human population. Fish farming represents a relevant, interesting and challenging system to study emerging pathogens. This review summarizes recent progress in pathogen discovery using sequence data, with particular emphasis on viruses in Atlantic salmon (Salmo salar).
Department of Chemistry, Biotechnology and Food Sciences, Faculty of Veterinary Medicine and Biosciences, Norwegian University of Life Sciences, 1430 Aas, Norway. Electronic address: torstein.tengs@nmbu.no.
Torstein
T
Tengs
Department of Food Safety and Infectious Biology, Faculty of Veterinary Medicine and Biosciences, Norwegian University of Life Sciences, 0033 Oslo, Norway.
Espen
E
Rimstad
D000818:Animals; D019295:Computational Biology; D005393:Fish Diseases / Q000235:genetics* / Q000276:immunology; D005398:Fisheries; D005399:Fishes / Q000235:genetics* / Q000276:immunology; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D020317:Salmo salar / Q000821:virology*; D059467:Transcriptome; D014777:Virus Diseases / Q000235:genetics*
Atlantic salmon; Next generation sequencing; PMCV; PRV; SGPV; Salmo salar