Cerium oxide nanoparticles: a 'radical' approach to neurodegenerative disease treatment.
Despite advances in understanding the factors that cause many neurodegenerative diseases (NDs), no current therapies have yielded significant results. Cerium oxide nanoparticles (CeONPs) have recently emerged as therapeutics for the treatment of NDs due to their antioxidant properties. This report summarizes the recent findings regarding CeONPs in treatment of various NDs, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, ischemic stroke and amyotrophic lateral sclerosis. Interest in CeONPs as a potential nanomedicine for NDs has increased due to: their ability to alter signaling pathways, small diameter allowing passage through the blood-brain barrier and scavenging of reactive oxygen species. Due to these properties, CeONPs could eventually revolutionize existing treatments for NDs.
Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Shuguftha
S
Naz
Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
James
J
Beach
Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Blaze
B
Heckert
Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Tanuja
T
Tummala
Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Oleksandra
O
Pashchenko
Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Tuhina
T
Banerjee
Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Santimukul
S
Santra
D000544:Alzheimer Disease / Q000188:drug therapy; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy; D001812:Blood-Brain Barrier / Q000187:drug effects; D002563:Cerium / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy; D050997:Nanomedicine / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy
D002563:Cerium; C030583:ceric oxide
antioxidant; cerium oxide nanoparticles; neurodegenerative diseases; oxidative stress