Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers.
This study aimed to analyze the interaction of Angiotensin II type 1 receptor (AT1R) gene polymorphism and occupational noise on the occurrence of essential hypertension (EH) in steel and iron enterprise men workers.



A case control study of 935 iron and steel enterprise men workers was conducted, which included 312 cases of hypertension and 623 cases without hypertension. The noise at the workplace was assessed. Polymorphism of AT1R of the workers was examined using polymerase chain reaction - restriction fragment length polymorphism.



Polymorphism of AT1R (AC+CC vs. AA, odds ratio [OR] = 1.760, 95% confidence interval [CI]: 1.061∼2.920) and noise (greater than or equal to 85 dB(A),OR = 1.641, 95%CI: 1.225∼2.198) were independent determinants of EH using multivariate Logistic regression. Compared with AA carriers without noise, AC+CC interacted with noise (OR = 2.519, 95%CI: 1.254∼5.062) based on the multiplied model.



AC+CC genotype of AT1R and noise were the risky factors of EH. These factors also interacted with each other.
School of Public Health, China Medical University (Drs Tong, Yuan); School of Public Health/Hebei Province Coal Mine Health and Safety Laboratory, North China University of Science and Technology (Drs Tong, Yuan, Zheng, Chai, Li); Department of Endocrinology, North China University of Science and Technology Affiliated Hospital (Dr Wang); Tangshan Iron and Steel Group Co., LTD (Dr Yang); Tangshan Hongci Hospital (Dr Wang), P. R. China.
Junwang
J
Tong
Ying
Y
Wang
Juxiang
J
Yuan
Jingbo
J
Yang
Zhaoyang
Z
Wang
Yao
Y
Zheng
Feng
F
Chai
Xiangwen
X
Li
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D000075222:Essential Hypertension / Q000453:epidemiology* / Q000209:etiology; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D007501:Iron; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors; D013232:Steel
D044140:Receptor, Angiotensin, Type 1; D013232:Steel; D007501:Iron