Anti-inflammatory pentacyclic triterpenes from the stems of Euonymus carnosus.
Three new lupane-type triterpenoids (1-3), three new oleane-type triterpenoids (4-6), as well as two known compounds (7-8) were isolated from Euonymus carnosus. The structures of the compounds were elucidated on the basis of spectroscopic data analyses, including UV, IR, MS, and NMR experiments. The inhibitory on LPS-induced NO production in microglia BV2 cells of compounds 1-8 were also evaluated. Compounds 1 and 2 showed moderate abilities to inhibit NO production, with IC50values of 5.99 and 8.47μM, respectively.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Jian
J
Zhou
Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Xiao-Hua
XH
Wei
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Fang-You
FY
Chen
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Chuang-Jun
CJ
Li
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Jing-Zhi
JZ
Yang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Jie
J
Ma
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Xiu-Qi
XQ
Bao
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Dan
D
Zhang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: zhangdm@imm.ac.cn.
Dong-Ming
DM
Zhang
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D002460:Cell Line; D051379:Mice; D017628:Microglia / Q000187:drug effects*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D053978:Pentacyclic Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D018547:Plant Stems / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D053978:Pentacyclic Triterpenes; D009569:Nitric Oxide
Anti-inflammatory; Celastraceae; Euonymus carnosus; Pentacyclic triterpenes