Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.
School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.|Host-Pathogen Genomic Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
István
I
Bartha
National HIV and Retrovirology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.|Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.
Paul J
0000-0001-6019-7018
PJ
McLaren
BC Centre for Excellence in HIV/AIDS, University of British Columbia, Vancouver, British Columbia, Canada.
Chanson
C
Brumme
BC Centre for Excellence in HIV/AIDS, University of British Columbia, Vancouver, British Columbia, Canada.
Richard
R
Harrigan
Genomic Medicine Group, J. Craig Venter Institute, La Jolla, California, United States of America.
Amalio
0000-0001-6290-7677
A
Telenti
School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.|Host-Pathogen Genomic Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Jacques
0000-0002-8240-939X
J
Fellay
D016915:AIDS Vaccines / Q000627:therapeutic use; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D015894:Genome, Human / Q000235:genetics*; D016679:Genome, Viral / Q000235:genetics*; D006678:HIV / Q000235:genetics*; D015658:HIV Infections / Q000235:genetics* / Q000628:therapy; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D019562:Viral Load / Q000235:genetics*
D016915:AIDS Vaccines