Assessment of renal function and electrolytes in patients with thyroid dysfunction in Addis Ababa, Ethiopia: a cross sectional study.
BACKGROUND
Studies demonstrated that abnormal thyroid functions may result in decreased or increased kidney size, kidney weight, and affect renal functions. In this regard, studies on the association of abnormal thyroid functions and renal function tests are scarcely found in Ethiopia.


OBJECTIVE
To assess renal function and electrolytes in patients with thyroid dysfunction, in Addis Ababa, Ethiopia.


METHODS
Cross sectional study was conducted from March 21/2015-May 27/2015 at Arsho Advanced Medical Laboratory. During the study period, 71 patients with thyroid dysfunction were eligible, and socio demographic data collected by structured questionnaire. Then blood sample was collected for thyroid function tests, renal function and blood electrolyte analysis. The collected data was analyzed by SPSS version 20. ANOVA and binary logistic regression were employed to evaluate the mean deference and associations of thyroid hormone with renal function and electrolyte balances.


RESULTS
Among the renal function tests, serum uric acid, and creatinine mean values were significantly decreased in hyperthyroid patients; whereas, eGFR mean value was significantly increased in hyperthyroid study patients (P<0.05). Meanwhile, from the electrolyte measurements made, only the mean serum sodium value was significantly increased in hyperthyroid study participants. Binary logistic regression analysis on the association of thyroid dysfunction with electrolyte balance and renal function tests indicated that serum sodium, creatinine, eGFR values and hyperthyroidism have a statistical significant association at AOR 95% CI of 0.141(0.033-0.593, P=0.008); 16.236(3.481-75.739, P=0.001), and 13.797(3.261-58.67, P=0.001) respectively.


CONCLUSIONS
The current study reveals, thyroid abnormalities may lead to renal function alterations and also may disturb electrolyte balance. Knowledge of this significant association has worthwhile value for clinicians, to manage their patients' optimally.
Bethzatha Advanced Medical Laboratory and Registered Assessor of ISO 15189, Addis Abeba, Ethiopia.
Nardos
N
Abebe
Department of Internal medicine, College of Health Science, Addis Abeba University, Ethiopia.
Tedla
T
Kebede
Department of Medical Laboratory Sciences, College of Health Science, Addis Abeba University, Ethiopia.
Mistire
M
Wolde
D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D004573:Electrolytes / Q000378:metabolism; D005002:Ethiopia; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology* / Q000503:physiopathology; D007677:Kidney Function Tests; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D013959:Thyroid Diseases / Q000150:complications / Q000503:physiopathology*; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology*; D055815:Young Adult
D004573:Electrolytes; D013963:Thyroid Hormones
Thyroid dysfunction; blood electrolyte; renal function tests