Rare and low-frequency coding variants alter human adult height.
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Eirini
E
Marouli
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Mariaelisa
M
Graff
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.|Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Carolina
C
Medina-Gomez
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
Ken Sin
KS
Lo
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Andrew R
AR
Wood
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark.
Troels R
TR
Kjaer
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.|Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Rebecca S
RS
Fine
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.|The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.
Yingchang
Y
Lu
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.
Claudia
C
Schurmann
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.|Human Genetics Center, The University of Texas School of Public Health, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Heather M
HM
Highland
Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.|Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
Sina
S
Rüeger
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.
Gudmar
G
Thorleifsson
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Anne E
AE
Justice
Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.|Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland.
David
D
Lamparter
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.|Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.
Kathleen E
KE
Stirrups
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
Valérie
V
Turcot
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Kristin L
KL
Young
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.
Thomas W
TW
Winkler
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.|Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Tõnu
T
Esko
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Tugce
T
Karaderi
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.|McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, Missouri 63108, USA.
Adam E
AE
Locke
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.|NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Nicholas G D
NG
Masca
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.|Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Maggie C Y
MC
Ng
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Poorva
P
Mudgal
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Nuffield Department of Clinical Medicine, Oxford OX3 7BN, UK.
Manuel A
MA
Rivas
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.|Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Sailaja
S
Vedantam
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Anubha
A
Mahajan
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Xiuqing
X
Guo
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Goncalo
G
Abecasis
Netherlands Comprehensive Cancer Organisation, Utrecht, 3501 DB, The Netherlands.|Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Katja K
KK
Aben
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Linda S
LS
Adair
Centre for Control of Chronic Diseases (CCCD), Dhaka, 1212, Bangladesh.
Dewan S
DS
Alam
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Eva
E
Albrecht
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Kristine H
KH
Allin
Department of Family Medicine &Public Health, University of California, San Diego, La Jolla, California 92093, USA.
Matthew
M
Allison
INSERM U1167, Lille, F-59019, France.|Institut Pasteur de Lille, U1167, Lille, F-59019, France.|Universite de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, F-59019, France.
Philippe
P
Amouyel
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Emil V
EV
Appel
Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, F-67085, France.|Department of Public Health, University Hospital of Strasbourg, Strasbourg, 67081, France.
Dominique
D
Arveiler
Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.|Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.|Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
Folkert W
FW
Asselbergs
Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA.
Paul L
PL
Auer
INSERM U1018, Centre de recherche en Épidemiologie et Sante des Populations (CESP), Villejuif, France.
Beverley
B
Balkau
Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
Bernhard
B
Banas
Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Lia E
LE
Bang
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Marianne
M
Benn
Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.|Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland.
Sven
S
Bergmann
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Lawrence F
LF
Bielak
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.|University of Leipzig, Department of Medicine, Leipzig, 04103, Germany.
Matthias
M
Blüher
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Heiner
H
Boeing
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.|Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Eric
E
Boerwinkle
Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
Carsten A
CA
Böger
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Lori L
LL
Bonnycastle
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Jette
J
Bork-Jensen
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Michiel L
ML
Bots
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Erwin P
EP
Bottinger
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.|Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.|Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Donald W
DW
Bowden
Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, 7100, Denmark.|Institute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark.
Ivan
I
Brandslund
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London &NIHR Biomedical Research Centre for Mental Health at the Maudsley, London, SE5 8AF, UK.
Gerome
G
Breen
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
Murray H
MH
Brilliant
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Linda
L
Broer
Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Amber A
AA
Burt
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.|NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK.
Adam S
AS
Butterworth
The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.
David J
DJ
Carey
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.|NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK.
Mark J
MJ
Caulfield
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.|Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.|Imperial College Healthcare NHS Trust, London W12 0HS, UK.
John C
JC
Chambers
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.|Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.|Harvard Medical School, Boston, Massachusetts 02115, USA.
Daniel I
DI
Chasman
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Yii-Der Ida
YI
Chen
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Rajiv
R
Chowdhury
Medical Department, Lillebaelt Hospital, Vejle, 7100, Denmark.
Cramer
C
Christensen
Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.|NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Audrey Y
AY
Chu
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, 34100, Italy.
Massimiliano
M
Cocca
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Francis S
FS
Collins
Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
James P
JP
Cook
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Janie
J
Corley
Department of Human Genetics, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Jordi Corominas
JC
Galbany
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.|Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.|Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Amanda J
AJ
Cox
Diamantina Institute, University of Qeensland, Brisbane, Queensland, 4072, Australia.|QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Gabriel
G
Cuellar-Partida
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.|NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK.|Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.|British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
John
J
Danesh
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Gail
G
Davies
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.|Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Paul I W
PI
de Bakker
Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Gert J
GJ
de Borst
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.|Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Simon
S
de Denus
Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands.|Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology &Clinical Pharmacology, Utrecht University, Utrecht, 3508 TB, The Netherlands.
Mark C H
MC
de Groot
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Renée
R
de Mutsert
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Ian J
IJ
Deary
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
George
G
Dedoussis
Division of Epidemiology &Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA.
Ellen W
EW
Demerath
Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Anneke I
AI
den Hollander
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Joe G
JG
Dennis
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.|NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK.
Emanuele
E
Di Angelantonio
Institute of Cardiovascular Science, University College London, London WC1E 6JF, UK.|MRC Integrative Epidemiology Unit, School of Social &Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Fotios
F
Drenos
Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, Washington 98109, USA.|Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, New York 10017, USA.
Mengmeng
M
Du
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Alison M
AM
Dunning
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.|Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Douglas F
DF
Easton
Department of Medicine, Oulu University Hospital, Oulu, 90029, Finland.|Research Unit of Internal Medicine, University of Oulu, Oulu, FI-90014, Finland.
Tapani
T
Ebeling
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
Todd L
TL
Edwards
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.
Patrick T
PT
Ellinor
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
Paul
P
Elliott
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.|Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Evangelos
E
Evangelou
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
Aliki-Eleni
AE
Farmaki
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA.
Jessica D
JD
Faul
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA.
Mary F
MF
Feitosa
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Shuang
S
Feng
CNR Institute of Clinical Physiology, Pisa, Italy.|Department of Clinical &Experimental Medicine, University of Pisa, Pisa, Italy.
Ele
E
Ferrannini
Research Center on Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, 21100, Italy.
Marco M
MM
Ferrario
Toulouse University School of Medicine, Toulouse, TSA 50032 31059, France.
Jean
J
Ferrieres
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.|Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA.
Jose C
JC
Florez
University of Glasgow, Glasgow G12 8QQ, UK.
Ian
I
Ford
Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Myriam
M
Fornage
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.|Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.|Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, 901 87, Sweden.
Paul W
PW
Franks
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.|Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Ruth
R
Frikke-Schmidt
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Tessel E
TE
Galesloot
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Wei
W
Gan
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
Ilaria
I
Gandin
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.|Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar.
Paolo
P
Gasparini
Geriatrics, Department of Public Health, Uppsala University, Uppsala, 751 85, Sweden.
Vilmantas
V
Giedraitis
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
Ayush
A
Giri
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.|Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar.
Giorgia
G
Girotto
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Scott D
SD
Gordon
Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.|Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Penny
P
Gordon-Larsen
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.|Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
Mathias
M
Gorski
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Niels
N
Grarup
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Megan L
ML
Grove
Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.|Icelandic Heart Association, Kopavogur, 201, Iceland.
Vilmundur
V
Gudnason
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden.
Stefan
S
Gustafsson
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Torben
T
Hansen
Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.|Department of Sociology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Kathleen Mullan
KM
Harris
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA.
Tamara B
TB
Harris
University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Andrew T
AT
Hattersley
MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Caroline
C
Hayward
Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA.|Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.
Liang
L
He
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.|Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Iris M
IM
Heid
Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.|Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Kauko
K
Heikkilä
Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.|KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.
Øyvind
Ø
Helgeland
Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, 33521, Finland.|Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.|Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland.
Jussi
J
Hernesniemi
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, 3002, Australia.|Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia.|Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, 7000, Australia.
Alex W
AW
Hewitt
Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.|Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Lynne J
LJ
Hocking
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Mette
M
Hollensted
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway.
Oddgeir L
OL
Holmen
AMC, Department of Vascular Medicine, Amsterdam, 1105 AZ, The Netherlands.
G Kees
GK
Hovingh
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Joanna M M
JM
Howson
Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Carel B
CB
Hoyng
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Paul L
PL
Huang
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7600, Norway.
Kristian
K
Hveem
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.|Department of Neurology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.|Department of Radiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
M Arfan
MA
Ikram
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden.|Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
Erik
E
Ingelsson
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Anne U
AU
Jackson
Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.|Research Unit Skellefteå, Skellefteå, SE-93141, Sweden.
Jan-Håkan
JH
Jansson
Department of Medicine, University of Washington, Seattle, Washington 98195, USA.|Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Gail P
GP
Jarvik
The Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, 2000, Denmark.
Gorm B
GB
Jensen
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Min A
MA
Jhun
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Yucheng
Y
Jia
Department of Preventive Medicine, Keck School of Medicine of the University of California, Los Angeles, California 90089, USA.|USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA.
Xuejuan
X
Jiang
KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.|Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5021, Norway.
Stefan
S
Johansson
National Institute of Public Health, University of Southern Denmark, Copenhagen, 1353, Denmark.|Steno Diabetes Center, Gentofte, 2820, Denmark.
Marit E
ME
Jørgensen
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.|Aalborg University, Aalborg, DK-9000, Denmark.|Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.
Torben
T
Jørgensen
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Pekka
P
Jousilahti
Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.|The Interuniversity Cardiology Institute of the Netherlands, Utrecht, 2333, The Netherlands.
J Wouter
JW
Jukema
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.|Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Bratati
B
Kahali
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.
René S
RS
Kahn
Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, 33014, Finland.
Mika
M
Kähönen
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
Pia R
PR
Kamstrup
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Stavroula
S
Kanoni
Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.|Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.|National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Jaakko
J
Kaprio
Echinos Medical Centre, Echinos, Greece.
Maria
M
Karaleftheri
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Sharon L R
SL
Kardia
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.|Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Fredrik
F
Karpe
UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast BT12 6BJ, UK.
Frank
F
Kee
Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands.
Renske
R
Keeman
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Lambertus A
LA
Kiemeney
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Hidetoshi
H
Kitajima
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Kirsten B
KB
Kluivers
Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, 17475, Germany.
Thomas
T
Kocher
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Pirjo
P
Komulainen
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Jukka
J
Kontto
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.|Imperial College Healthcare NHS Trust, London W12 0HS, UK.|National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.
Jaspal S
JS
Kooner
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Charles
C
Kooperberg
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.
Peter
P
Kovacs
German Center for Diabetes Research, München-Neuherberg, 85764, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.|Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Jennifer
J
Kriebel
The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.|Department of Psychiatry, and Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa.
Helena
H
Kuivaniemi
CHU Nantes, Service de Génétique Médicale, Nantes, 44093, France.
Sébastien
S
Küry
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Johanna
J
Kuusisto
Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
Martina
M
La Bianca
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Markku
M
Laakso
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.|Institute of Biomedicine &Physiology, University of Eastern Finland, Kuopio, 70210, Finland.
Timo A
TA
Lakka
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Ethan M
EM
Lange
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Leslie A
LA
Lange
Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Carl D
CD
Langefeld
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Claudia
C
Langenberg
Department of Medicine, University of Washington, Seattle, Washington 98195, USA.|Group Health Research Institute, Seattle, Washington 98101, USA.|Department of Health Services, University of Washington, Seattle, Washington 98101, USA.
Eric B
EB
Larson
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.|School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
I-Te
IT
Lee
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.|Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland.
Terho
T
Lehtimäki
Division of Preventive Medicine University of Alabama at Birmingham, Birmingham, Alabama 35205, USA.
Cora E
CE
Lewis
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Huaixing
H
Li
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
Jin
J
Li
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Ruifang
R
Li-Gao
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Honghuang
H
Lin
Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Li-An
LA
Lin
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Xu
X
Lin
Uppsala University, Uppsala, 75185, Sweden.
Lars
L
Lind
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Jaana
J
Lindström
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.|Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.|Department of Experimental Medicine, Rigshospitalet, Copenhagen, DK-2200, Denmark.
Allan
A
Linneberg
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Yeheng
Y
Liu
Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Yongmei
Y
Liu
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Artitaya
A
Lophatananon
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Jian'an
J
Luan
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.
Steven A
SA
Lubitz
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.|Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland.
Leo-Pekka
LP
Lyytikäinen
Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia.
David A
DA
Mackey
Department of Psychiatry, Washington University, Saint Louis, Missouri 63110, USA.
Pamela A F
PA
Madden
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.|Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA.
Alisa K
AK
Manning
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Satu
S
Männistö
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Gaëlle
G
Marenne
MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Jonathan
J
Marten
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Nicholas G
NG
Martin
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Angela L
AL
Mazul
German Center for Diabetes Research, München-Neuherberg, 85764, Germany.|Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Karina
K
Meidtner
Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Andres
A
Metspalu
Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, 2022, Australia.
Paul
P
Mitchell
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Karen L
KL
Mohlke
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.|Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Dennis O
DO
Mook-Kanamori
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
Anna
A
Morgan
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
Andrew D
AD
Morris
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Andrew P
AP
Morris
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.|Department of Medicine I, Ludwig-Maximilians-Universität, Munich, 81377, Germany.|DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, 80802, Germany.
Martina
M
Müller-Nurasyid
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.|NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK.
Patricia B
PB
Munroe
Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
Mike A
MA
Nalls
DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.|Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Matthias
M
Nauck
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.|NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Christopher P
CP
Nelson
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.|Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Matt
M
Neville
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Sune F
SF
Nielsen
Department of Cardiology, Heart Center, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, 33521, Finland.
Kjell
K
Nikus
Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.|KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.
Pål R
PR
Njølstad
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Børge G
BG
Nordestgaard
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Ioanna
I
Ntalla
Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Jeffrey R
JR
O'Connel
Department of Medicine, Tampere University Hospital, Tampere, 33521, Finland.
Heikki
H
Oksa
Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA.
Loes M Olde
LM
Loohuis
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.|Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA.
Roel A
RA
Ophoff
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.|Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Katharine R
KR
Owen
University of Glasgow, Glasgow G12 8QQ, UK.
Chris J
CJ
Packard
University of Glasgow, Glasgow G12 8QQ, UK.
Sandosh
S
Padmanabhan
Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Colin N A
CN
Palmer
Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.|Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Gerard
G
Pasterkamp
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Harvard Medical School, Boston, Massachusetts 02115, USA.|Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Aniruddh P
AP
Patel
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Alison
A
Pattie
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Oluf
O
Pedersen
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
Peggy L
PL
Peissig
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.
Gina M
GM
Peloso
School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia.
Craig E
CE
Pennell
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.|University of Helsinki, Institute for Molecular Medicine (FIMM) and Diabetes and Obesity Research Program, Helsinki, FI00014, Finland.|University of Tartu, Estonian Genome Center, Tartu, Estonia, Tartu, 51010, Estonia.
Markus
M
Perola
Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
James A
JA
Perry
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
John R B
JR
Perry
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
Thomas N
TN
Person
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Ailith
A
Pirie
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.|School of Medicine, University of Split, Split, 21000, Croatia.
Ozren
O
Polasek
Center for Neurogenomics and Cognitive Research, Department Complex Trait Genetics, VU University, Amsterdam, 1081 HV, The Netherlands.|Neuroscience Campus Amsterdam, Department Clinical Genetics, VU Medical Center, Amsterdam, 1081 HV, The Netherlands.
Danielle
D
Posthuma
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.|Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Olli T
OT
Raitakari
Centre for Non-Communicable Diseases, Karachi, Pakistan.
Asif
A
Rasheed
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, Finland.
Rainer
R
Rauramaa
MRL, Merck &Co., Inc., Genetics and Pharmacogenomics, Boston, Massachusetts 02115, USA.
Dermot F
DF
Reilly
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.|Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA.
Alex P
AP
Reiner
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.|Department of Biobank Research, Umeå University, Umeå, SE-90187, Sweden.
Frida
F
Renström
Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.|Harvard Medical School, Boston, Massachusetts 02115, USA.|Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Paul M
PM
Ridker
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.|Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
John D
JD
Rioux
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Neil
N
Robertson
Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
Antonietta
A
Robino
Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.|Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, 90185, Sweden.
Olov
O
Rolandsson
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
Igor
I
Rudan
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Katherine S
KS
Ruth
Centre for Non-Communicable Diseases, Karachi, Pakistan.|Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Danish
D
Saleheen
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Veikko
V
Salomaa
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.|NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Nilesh J
NJ
Samani
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Kevin
K
Sandow
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Yadav
Y
Sapkota
University of Glasgow, Glasgow G12 8QQ, UK.
Naveed
N
Sattar
Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands.
Marjanka K
MK
Schmidt
Division of Epidemiology &Community Health University of Minnesota, Minneapolis, Minnesota 55454, USA.
Pamela J
PJ
Schreiner
German Center for Diabetes Research, München-Neuherberg, 85764, Germany.|Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Matthias B
MB
Schulze
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Robert A
RA
Scott
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.
Marcelo P
MP
Segura-Lepe
Duke University, Durham, North Carolina 27703, USA.
Svati
S
Shah
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Xueling
X
Sim
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Departement of Haematology, University of Cambridge, Cambridge CB2 OPT, UK.|Department of Vascular Medicine, AMC, Amsterdam, 1105 AZ, The Netherlands.
Suthesh
S
Sivapalaratnam
Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK.
Kerrin S
KS
Small
Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.|Icelandic Heart Association, Kopavogur, 201, Iceland.
Albert Vernon
AV
Smith
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jennifer A
JA
Smith
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Lorraine
L
Southam
Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK.
Timothy D
TD
Spector
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.|Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Elizabeth K
EK
Speliotes
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.|Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK.
John M
JM
Starr
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.
Valgerdur
V
Steinthorsdottir
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Heather M
HM
Stringham
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.|University of Leipzig, Department of Medicine, Leipzig, 04103, Germany.
Michael
M
Stumvoll
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Praveen
P
Surendran
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands.|Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.|Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.
Leen M
LM
't Hart
College of Biomedical and Life Sciences, Cardiff University, Cardiff, CF14 4EP, UK.|MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Katherine E
KE
Tansey
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.|Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Jean-Claude
JC
Tardif
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Kent D
KD
Taylor
Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Alexander
A
Teumer
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Deborah J
DJ
Thompson
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Unnur
U
Thorsteinsdottir
Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.
Betina H
BH
Thuesen
Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, 04103, Germany.
Anke
A
Tönjes
The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.|Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa.
Gerard
G
Tromp
Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.|Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Stella
S
Trompet
Anogia Medical Centre, Anogia, Greece.
Emmanouil
E
Tsafantakis
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.|Centre for Vascular Prevention, Danube-University Krems, Krems, 3500, Austria.|Dasman Diabetes Institute, Dasman, 15462, Kuwait.|Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Jaakko
J
Tuomilehto
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.|Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Anne
A
Tybjaerg-Hansen
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Jonathan P
JP
Tyrer
Department of Psychiatry, Dalhousie University, Halifax B3H 4R2, Canada.
Rudolf
R
Uher
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.|Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
André G
AG
Uitterlinden
Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
Sheila
S
Ulivi
Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Sander W
SW
van der Laan
University of Amsterdam, Department of Brain &Cognition, Amsterdam, 1018 WS, The Netherlands.
Andries R
AR
Van Der Leij
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Cornelia M
CM
van Duijn
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands.
Natasja M
NM
van Schoor
Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Jessica
J
van Setten
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Anette
A
Varbo
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.
Tibor V
TV
Varga
USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA.
Rohit
R
Varma
Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
Digna R Velez
DR
Edwards
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Sita H
SH
Vermeulen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Henrik
H
Vestergaard
MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Veronique
V
Vitart
MRL, Merck &Co., Inc., Cardiometabolic Disease, Kenilworth, New Jersey 07033, USA.
Thomas F
TF
Vogt
Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar.
Diego
D
Vozzi
Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle NE2 4HH, UK.
Mark
M
Walker
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Feijie
F
Wang
School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia.
Carol A
CA
Wang
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Shuai
S
Wang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Yiqin
Y
Wang
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Nicholas J
NJ
Wareham
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.|NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK.
Helen R
HR
Warren
Departments of Epidemiology &Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health &School of Medicine, Indiana University, Indiana 46202, USA.
Jennifer
J
Wessel
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Sara M
SM
Willems
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
James G
JG
Wilson
Danish Diabetes Academy, Odense, 5000, Denmark.|Department of Public Health, Aarhus University, Aarhus, 8000, Denmark.
Daniel R
DR
Witte
Memorial University, Faculty of Medicine, Discipline of Genetics, St. John's, Newfoundland A1B 3V6, Canada.
Michael O
MO
Woods
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Ying
Y
Wu
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Hanieh
H
Yaghootkar
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Jie
J
Yao
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Pang
P
Yao
Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.|GlaxoSmithKlein, King of Prussia, Pennsylvania 19406, USA.
Laura M
LM
Yerges-Armstrong
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.|University of Glasgow, Glasgow G12 8QQ, UK.
Robin
R
Young
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Eleftheria
E
Zeggini
Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Xiaowei
X
Zhan
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.|Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.
Weihua
W
Zhang
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Jing Hua
JH
Zhao
Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Wei
W
Zhao
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Wei
W
Zhao
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
He
H
Zheng
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
Wei
W
Zhou
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Jerome I
JI
Rotter
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Michael
M
Boehnke
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Harvard Medical School, Boston, Massachusetts 02115, USA.|Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Sekar
S
Kathiresan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.|Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Mark I
MI
McCarthy
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.|Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Cristen J
CJ
Willer
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Kari
K
Stefansson
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA.
Ingrid B
IB
Borecki
Department of Public Health Sciences, Institute for Personalized Medicine, the Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.
Dajiang J
DJ
Liu
Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, North Carolina 27514, USA.
Kari E
KE
North
NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA.|Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Nancy L
NL
Heard-Costa
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.|Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2200, Denmark.
Tune H
TH
Pers
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford OX3 7BN, UK.
Cecilia M
CM
Lindgren
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark.
Claus
C
Oxvig
Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.|Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
Zoltán
Z
Kutalik
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.|Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Fernando
F
Rivadeneira
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.|The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.
Ruth J F
RJ
Loos
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Timothy M
TM
Frayling
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.|Departments of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Joel N
JN
Hirschhorn
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.|Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Panos
P
Deloukas
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.|Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Guillaume
G
Lettre
D000071096:ADAMTS Proteins / Q000235:genetics; D000328:Adult; D000483:Alleles; D001827:Body Height / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006025:Glycosaminoglycans / Q000096:biosynthesis; D053823:Hedgehog Proteins / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D050835:Interferon Regulatory Factors / Q000235:genetics; D053703:Interleukin-11 Receptor alpha Subunit / Q000235:genetics; D008297:Male; D020412:Multifactorial Inheritance / Q000235:genetics; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases / Q000235:genetics; D010641:Phenotype; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D011348:Procollagen N-Endopeptidase / Q000235:genetics; D011509:Proteoglycans / Q000096:biosynthesis; D059748:Proteolysis; D011944:Receptors, Androgen / Q000235:genetics; D013002:Somatomedins / Q000378:metabolism
C410798:AR protein, human; C525599:CRISPLD2 protein, human; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D006025:Glycosaminoglycans; D053823:Hedgehog Proteins; C509246:IHH protein, human; C508428:IL11RA protein, human; D036341:Intercellular Signaling Peptides and Proteins; D050835:Interferon Regulatory Factors; D053703:Interleukin-11 Receptor alpha Subunit; D011509:Proteoglycans; D011944:Receptors, Androgen; C114997:STC2 protein, human; D013002:Somatomedins; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases; C498910:NOX4 protein, human; D000071096:ADAMTS Proteins; C434951:ADAMTS3 protein, human; D011266:Pregnancy-Associated Plasma Protein-A; D011348:Procollagen N-Endopeptidase