Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall.
Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Immunohistochemical analysis with antibodies against CD31, CD56, CD68, CD117, S-100 protein, inhibin, calretinin, EMA, p53 and MIB-1 was performed, showing expression of CD56, CD68, S-100 protein, inhibin and calretinin. The diagnosis of atypical dermatofibroma-like GCT was made.
The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic. 2jiri.soukup@gmail.com.
Jiri
J
Soukup
The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic.
Dimitar
D
Hadzi-Nikolov
The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic.
Ales
A
Ryska
D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D016586:Granular Cell Tumor / Q000175:diagnosis*; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor
 S100;  soft tissue tumours; granular cell tumour