Intracranial neuromuscular choristoma: Report of a case with literature review.
Neuromuscular choristoma (NMC), also called neuromuscular hamartoma or nerve rhabdomyoma, is a rare lesion of the spinal and cranial nerves composed of skeletal muscle intimately associated with nerve fibers. Its origin has not been precisely clarified and a malformative event, resulting from aberrant differentiation or a true neoplastic growth, have been proposed by authors. We hereby present a cerebellopontine angle NMC enlarging the eighth cranial nerve in a 3-year-old child, that histologically appeared composed of a large amount of striated muscle mixed with nerve fibers. We also provide a review of the intracranial NMC cases reported in the literature and an analysis of proposed hypotheses to explain the presence of muscle cells in nerve trunks.
Department of Anatomic Pathology, Catholic University, Rome, Italy.
Antonella
http://orcid.org/0000-0001-6366-3993
A
Coli
Department of Anatomic Pathology, Catholic University, Rome, Italy.
Mariangela
M
Novello
Department of Pediatric Neurosurgery, Catholic University, Rome, Italy.
Gianpiero
G
Tamburrini
Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza, University of Rome, Rome, Italy.
Manila
M
Antonelli
Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza, University of Rome, Rome, Italy.|IRCCS Neuromed, Pozzilli (IS), Rome, Italy.
Felice
F
Giangaspero
Department of Anatomic Pathology, Catholic University, Rome, Italy.
Libero
L
Lauriola
D002526:Cerebellar Diseases / Q000473:pathology*; D002530:Cerebellopontine Angle / Q000473:pathology*; D002675:Child, Preschool; D002828:Choristoma; D006801:Humans; D018482:Muscle, Skeletal
choristoma; cranial nerves; neural crest; neuromuscular hamartoma; skeletal muscle