Validation of the Chinese version of Addenbrooke's Cognitive Examination III for diagnosing dementia.
The aim of this study was to validate the reliability of the Chinese version of Addenbrooke's Cognitive Examination III (ACE-III) for detecting dementia. Furthermore, the present study compares the diagnostic accuracy of ACE-III with that of mini-mental state examination (MMSE).



One hundred seventy-seven patients with dementia and 180 healthy controls were included in the study.



The reliability of ACE-III was very good (α-coefficient = 0.888). There was a significant negative correlation between Clinical Dementia Rating Scale score and total ACE-III score. Further, there was a positive correlation between MMSE score and total ACE-III score. Age exerted a significant effect on total ACE-III score, memory score, and language score. In the present study, the cutoff score of 83 showed a sensitivity of 91.1% and a specificity of 83.1%.



The present findings support that the Chinese version of ACE-III is a reliable assessment tool for dementia. Copyright © 2017 John Wiley & Sons, Ltd.
Department of Neurology, Jiangsu Geriatric Hospital, Jiangsu, China.
Bian-Rong
BR
Wang
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China.
Zhou
Z
Ou
Intensive Care Unit, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Jiangsu, China.
Xiao-Hua
XH
Gu
Department of Neurology, Affiliated Nanjing Jiangning Hospital, Nanjing Medical University, Jiangsu, China.
Cun-Sheng
CS
Wei
Department of Neurology, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Jiangsu, China.
Jun
0000-0001-5732-6376
J
Xu
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China.
Jian-Quan
JQ
Shi
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
Addenbrooke's Cognitive Examination III; Chinese; cognitive evaluation; dementia