A novel Enterovirus 96 circulating in China causes hand, foot, and mouth disease.
Enterovirus 96 (EV-96) is a recently described member of the species Enterovirus C and is associated with paralysis and myelitis. In this study, using metagenomic sequencing, we identified a new enterovirus 96 strain (EV-96-SZ/GD/CHN/2014) as the sole pathogen causing hand, foot, and mouth disease (HFMD). A genomic comparison showed that EV-96-SZ/GD/CHN/2014 is most similar to the EV-96-05517 strain (85% identity), which has also been detected in Guangdong Province. This is the first time that metagenomic sequencing has been used to identify an EV-96 strain shown to be associated with HFMD.
Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Jinsui Road No. 9, Guangzhou, 510120, China.
Yi
Y
Xu
BGI-Shenzhen, Shenzhen, 518083, China.
Yisuo
Y
Sun
BGI-Shenzhen, Shenzhen, 518083, China.
Jinmin
J
Ma
Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Jinsui Road No. 9, Guangzhou, 510120, China.|Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, 510120, China.
Shuru
S
Zhou
BGI-Shenzhen, Shenzhen, 518083, China.
Wei
W
Fang
Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Jinsui Road No. 9, Guangzhou, 510120, China.
Jiawei
J
Ye
Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Jinsui Road No. 9, Guangzhou, 510120, China.
Limei
L
Tan
BGI-Shenzhen, Shenzhen, 518083, China.
Jingkai
J
Ji
Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Jinsui Road No. 9, Guangzhou, 510120, China.
Dan
D
Luo
BGI-Shenzhen, Shenzhen, 518083, China.
Liqiang
L
Li
BGI-Shenzhen, Shenzhen, 518083, China.
Jiandong
J
Li
Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Jinsui Road No. 9, Guangzhou, 510120, China.
Chunxiao
C
Fang
BGI-Shenzhen, Shenzhen, 518083, China.
Na
N
Pei
BGI-Shenzhen, Shenzhen, 518083, China.
Shuo
S
Shi
BGI-Shenzhen, Shenzhen, 518083, China.
Xin
X
Liu
BGI-Shenzhen, Shenzhen, 518083, China.
Hui
H
Jiang
Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Jinsui Road No. 9, Guangzhou, 510120, China. sitangg@126.com.
Sitang
S
Gong
BGI-Shenzhen, Shenzhen, 518083, China. xuxun@genomics.cn.
Xun
X
Xu
D002675:Child, Preschool; D002681:China; D004770:Enterovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D030015:Enterovirus C, Human / Q000145:classification; D019143:Evolution, Molecular; D005243:Feces / Q000821:virology; D016679:Genome, Viral; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000821:virology*; D006801:Humans; D008297:Male; D056186:Metagenomics; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D017421:Sequence Analysis; D012703:Serotyping; D000073336:Whole Genome Sequencing
D012367:RNA, Viral
Enterovirus 96; Evolution; Genome sequence; HFMD; Metagenomics