Association of premorbid personality with behavioral and psychological symptoms in dementia with Lewy bodies: Comparison with Alzheimer's disease patients.
OBJECTIVE
The aim of this study was to elucidate the relation between premorbid personality traits and behavioral and psychological symptoms in dementia (BPSD) in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) patients.


METHODS
Forty-one DLB patients and 98 AD patients were assessed for BPSD using the Neuropsychiatric Inventory (NPI). Each patient's midlife personality traits were rated by a family member using the NEO Five-Factor Inventory (NEO-FFI) questionnaire.


RESULTS
In multiple regression analyses for DLB patients, NPI total score and anxiety were significantly associated with premorbid openness, delusion with premorbid agreeableness, and agitation with premorbid conscientiousness. In AD patients, depression was significantly associated with premorbid neuroticism, and agitation, apathy, and irritability with premorbid agreeableness.


CONCLUSIONS
Premorbid personalities affected BPSD differently in DLB and AD. Given the differences in the effects of premorbid personalities on BPSD, additional studies are needed to develop interventions to reduce these symptoms.
Department of Health Science, Asahikawa Medical University, Asahikawa, Japan.|Asahikawa Keisenkai Hospital, Asahikawa, Japan.
Kazuki
K
Tabata
Department of Health Science, Asahikawa Medical University, Asahikawa, Japan.
Yasuaki
Y
Saijo
Asahikawa Keisenkai Hospital, Asahikawa, Japan.
Fumiyoshi
F
Morikawa
Asahikawa Keisenkai Hospital, Asahikawa, Japan.
Juichiro
J
Naoe
Department of Health Science, Asahikawa Medical University, Asahikawa, Japan.
Eiji
E
Yoshioka
Department of Health Science, Asahikawa Medical University, Asahikawa, Japan.
Yasuyuki
Y
Kawanishi
Department of Health Science, Asahikawa Medical University, Asahikawa, Japan.
Yoshihiko
Y
Nakagi
Department of Health Science, Asahikawa Medical University, Asahikawa, Japan.
Takahiko
T
Yoshida
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis / Q000523:psychology*; D008297:Male; D010551:Personality; D010555:Personality Inventory

Alzheimer's disease; 
Neuropsychiatric Inventory; behavioral/psychological symptoms in dementia; dementia with Lewy bodies; premorbid personality