Role of Skin Biopsies in the Diagnosis of Hemophagocytic Lymphohistiocytosis.
This is a report of a 15-year-old female who presented with a skin eruption and clinical features consistent with severe sepsis and septic shock. A diagnosis of acquired hemophagocytic lymphohistiocytosis (HLH) was made and confirmed by bone marrow analysis. Skin biopsy showed hemophagocytosis and CD163-positive staining of macrophages. We briefly review the clinical, histologic, and laboratory findings of hemophagocytic lymphohistiocytosis in addition to the potential role of skin biopsies in this condition.
*Department of Dermatology, University of Puerto Rico-School of Medicine, San Juan, Puerto Rico; and †Transitional Year Program, University of Puerto Rico-School of Medicine, San Juan, Puerto Rico.
Aileen
A
Santos-Arroyo
Julián
J
Barrera-Llaurador
Julio E
JE
Sánchez
Rafael
R
Martín-García
Jorge L
JL
Sánchez
D000293:Adolescent; D001706:Biopsy; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis*; D012867:Skin / Q000473:pathology