Phenotype heterogeneity in dental pulp stem niches.
Dental stem niches (DSNs) reside in different dental tissues, being of particular importance in tissue engineering and dental regeneration procedures. The present paper aims to review the DSNs from the view of niche inhabitants, either extrinsic, such as cells of the myeloid lineage, or intrinsic, such as endothelial cells, perivascular cells and spindle-shaped stromal cells, e.g., telocytes. DSNs harbor different dental stem÷progenitor cell morphologies, in different stages of differentiation and with various potentialities, the angiogenic potential with respect to regenerative endodontic procedures being emphasized here. It seems therefore important to consider the DSNs as being heterogeneous, for a better understanding of an accurate identification of niche team players in regenerative medicine.
Division of Removable Prosthodontics, Department 1, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; melim.marina@gmail.com.
Paula
P
Perlea
Mugurel Constantin
MC
Rusu
Andreea Cristiana
AC
Didilescu
Elvira Floriana
EF
Pătroi
Rosalia Maria
RM
Leonardi
Marina
M
Imre
Anca Maria
AM
Răducanu
D002454:Cell Differentiation; D003782:Dental Pulp / Q000166:cytology / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D055153:Stem Cell Niche / Q000276:immunology*