Resveratrol ameliorates oxidative stress and organ dysfunction in Schistosoma mansoni infected mice.
Schistosoma mansoni causes a major chronic debilitating disease in more than 230 million people around the world. The pathognomonic granuloma is a major cause of the oxidative stress encountered as a consequence of infection not only in the liver, but also in other important organs as spleen, lung, brain and kidney. Resveratrol administration at a dose of 20 mg/kg once daily for two weeks to mice infected with Schistosoma mansoni resulted in improvement in serum cholesterol and triglyceride levels. Enzymatic antioxidant profile showed significant modulations in Superoxide dismutase, catalase activities and reduced glutathione levels. Specific biomarkers for homeostasis of brain and lung i.e. Tau and RAGE respectively, showed significant improvement after resveratrol administration.
Faculty of Medicine, Parasitology Department, Suez Canal University, Ismaillia, Egypt; Faculty of Medicine, Parasitology Department, Taif University, KSA. Electronic address: dr_rashasoliman@yahoo.com.
R H
RH
Soliman
Faculty of Medicine, Parasitology Department, Suez Canal University, Ismaillia, Egypt.
O A
OA
Ismail
Medical Research Center, Ain Shams University Hospital, Faculty of Medicine, Egypt.
M S
MS
Badr
Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt.
S M
SM
Nasr
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001798:Blood Proteins / Q000032:analysis; D001921:Brain / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism; D000077185:Resveratrol; D012550:Schistosoma mansoni / Q000187:drug effects / Q000502:physiology; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D016875:tau Proteins / Q000378:metabolism
C000593873:Ager protein, mouse; D000975:Antioxidants; D001798:Blood Proteins; D000067759:Receptor for Advanced Glycation End Products; D013267:Stilbenes; D014280:Triglycerides; D016875:tau Proteins; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D000077185:Resveratrol
Oxidative stress; RAGE; Resveratrol; Schistosoma mansoni; Tau