Prognostic Significance of the Expression of CD98 (4F2hc) in Gastric Cancer.
CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear. This study examined CD98 expression and its clinicopathological impact on GC.



Three hundred and thirty-one patients with surgically resected GC were evaluated. Tumor sections were stained and analyzed using immunohistochemistry to assess CD98 expression.



CD98 was positively expressed in 19% (66/331) of our patient cohort. Increased CD98 expression was significantly associated with advanced GC stage, lymph node metastasis, non-signet histology, lymphatic permeation, and vascular invasion. Positive CD98 expression was also a significant prediction marker for unfavorable prognosis postoperatively. However, CD98 was not identified as GC's independent prognostic predictor.



CD98 could be a novel prediction marker for worse prognosis in GC-affected patients. Our data suggests that increased CD98 expression plays an essential role in tumor aggressiveness and metastasis.
Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
Taisuke
T
Satoh
Department of Oncology Clinical Development, Gunma University Graduate School of Medicine, Gunma, Japan kkaira1970@yahoo.co.jp.
Kyoichi
K
Kaira
Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
Kengo
K
Takahashi
Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
Norihumi
N
Takahashi
Division of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yoshikatsu
Y
Kanai
Big Data Center for Integrative Analysis, Gunma University Initiative for Advance Research (GIAR), Gunma, Japan.
Takayuki
T
Asao
Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
Jun
J
Horiguchi
Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Gunma, Japan.
Tetsunari
T
Oyama
D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D005260:Female; D027261:Fusion Regulatory Protein-1 / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000706:statistics & numerical data; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; D027261:Fusion Regulatory Protein-1
CD98; Gastric cancer; amino acid transporter; immunohistochemistry; prognostic factor