Association Between Serum Zinc Levels and the Risk of Parkinson's Disease: a Meta-Analysis.
Recent studies have found that the serum zinc levels were associated with the risk of Parkinson's disease (PD), but the results were inconsistent. Thus, we conducted a meta-analysis to summarize the evidence from observational studies between them. Pertinent studies were identified by a search in PubMed, Embase, and Web of science up to July, 10, 2016. Standardized mean difference (SMD) and 95% confidence intervals (CI) with random-effect model was used to combine the results. Subgroup analysis and meta-regression were also conducted. Publication bias was estimated using Begg's regression asymmetry test. A total of 11 articles involving 822 PD patients and 777 healthy controls were included in the meta-analysis. Our meta-analysis results revealed that the serum zinc levels in PD patients were significantly lower than those in health controls (SMD = -0.779, 95%CI = [-1.323, -0.234], P < 0.001). The association was also significant oriental studies (SMD = -1.601, 95%CI = [-2.398, -0.805], P < 0.001). No publication bias was found. The current study indicated that serum zinc levels in PD patients were significantly lower than those in healthy controls.
School of Public Health College, Zhengzhou University, Science Road 100, Zhengzhou, 450001, China.
Hualei
H
Sun
School of Public Health College, Zhengzhou University, Science Road 100, Zhengzhou, 450001, China.
Xinxin
X
Liu
School of Public Health College, Zhengzhou University, Science Road 100, Zhengzhou, 450001, China.
Huina
H
Ge
School of Public Health College, Zhengzhou University, Science Road 100, Zhengzhou, 450001, China.
Teng
T
Wang
School of Public Health College, Zhengzhou University, Science Road 100, Zhengzhou, 450001, China.
Yan
Y
Wang
School of Public Health College, Zhengzhou University, Science Road 100, Zhengzhou, 450001, China. Lwj@zzu.edu.cn.
Wenjie
W
Li
D006801:Humans; D010300:Parkinson Disease / Q000097:blood*; D012307:Risk Factors; D015032:Zinc / Q000097:blood*
D015032:Zinc
Meta-analysis; Parkinson’s disease; Serum zinc levels