Phytochemical and pharmacological variability in Golden Thistle functional parts: comparative study of roots, stems, leaves and flowers.
Scolymus hispanicus or the Golden Thistle, locally known as 'Guernina' or 'Taghediwt', is one of the most appreciated wild vegetables in Morocco. This study aims to characterise the functional chemical and pharmacological variability of Scolymus hispanicus parts (roots, stems, leaves and flowers). The chemical analysis revealed higher content of α-tocopherol in the flowers (2.79 ± 0.07 mg/100 g) and lead to the identification of 3 flavonoids and 13 phenolic acids, with high content of gallic acid in leaves (187.01 ± 10.19 mg/kg); chlorogenic (936.18 ± 92.66 mg/kg) and caffeic (4400.14 ± 191.43 mg/kg) acids in flowers, roots were much more higher in sinapic acid (0.25 ± 0.03 mg/kg) compared to the other parts. Moreover, Scolymus hispanicus ethanolic extracts exhibited interesting antioxidant and antimicrobial properties, promising anti-amylase and anti-glucosidase activities and relevant diuretic effect that confirms its traditional uses.
a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
Ilias
http://orcid.org/0000-0002-0121-8939
I
Marmouzi
b Laboratoire de Contrôle de Qualité de Médicament, Division de Médicament et Pharmacie, Ministère de santé , Service de Physicochimie , Rabat , Morocco.
Miloud
M
El Karbane
c Faculté des Sciences Kénitra , Université Ibn Tofail , Rabat , Morocco.
Maha
M
El Hamdani
d Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Pharmaceutical and Toxicological Analysis Research Team , Mohammed V University in Rabat , Rabat , Morocco.|e Department of Analytical Chemistry and Pharmaceutical Technology, CePhaR , Vrije Universiteit Brussel (VUB) , Brussels , Belgium.
Mourad
http://orcid.org/0000-0003-0907-8819
M
Kharbach
a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
Hanae
http://orcid.org/0000-0002-8145-2572
H
Naceiri Mrabti
a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
Rachid
R
Alami
f Biochemistry Department , Military Hospital Mohammed V , Rabat , Morocco.
Souhail
S
Dahraoui
a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
Meryem
http://orcid.org/0000-0001-8365-9457
M
El Jemli
f Biochemistry Department , Military Hospital Mohammed V , Rabat , Morocco.
Zhor
Z
Ouzzif
a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
Yahia
http://orcid.org/0000-0001-7890-9028
Y
Cherrah
a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
Soufiane
S
Derraji
a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
My El Abbes
http://orcid.org/0000-0003-3863-4677
MEA
Faouzi
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D004232:Diuretics / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000032:analysis; D035264:Flowers / Q000737:chemistry*; D005707:Gallic Acid / Q000032:analysis; D062385:Hydroxybenzoates / Q000032:analysis; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D009018:Morocco; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D018547:Plant Stems; D031185:Scolymus / Q000737:chemistry*; D024502:alpha-Tocopherol / Q000032:analysis
D000890:Anti-Infective Agents; D000975:Antioxidants; D004232:Diuretics; D005419:Flavonoids; D062385:Hydroxybenzoates; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005707:Gallic Acid; D024502:alpha-Tocopherol; C017616:phenolic acid
Scolymus hispanicus; antidiabetic; antimicrobial; antioxidant; diuretic; phenolic