Corrosion behavior and cytocompatibility of fluoride-incorporated plasma electrolytic oxidation coating on biodegradable AZ31 alloy.
Fluoride-incorporated plasma electrolytic oxidation (PEO) coating was fabricated on biodegradable AZ31 alloy. The surface morphologies and phases were investigated by scanning electron microscopy and X-ray diffraction. The effect of fluoride incorporation in coatings on corrosion behaviour was investigated in simulated body fluid andin vitrocytocompatibility of the coatings was also studied by evaluating cytotoxicity, adhesion, proliferation and live-dead stain of osteoblast cells (MC3T3-E1). Furthermore, the corrosion morphologiesin vivowere examined. The results showed that the fluoride could be incorporated into the coating to form MgF2phase.In vitro and in vivodegradation tests revealed that the corrosion resistance of the coating could be improved by the incorporation of fluoride, which may attribute to the chemical stability of MgF2phase. Moreover, good cytocompatibility of fluoride-incorporated coating was confirmed with no obvious cytotoxicity, enhanced cell adhesion and proliferation. However, when the fluoride content was high, a slight inhibition of cell growth was observed. The results indicate that although fluoride incorporation can enhance the corrosion resistance of the coatings, thus resulting a more suitable environment for cells, the high content of fluoride in the coating also kill cells ascribed to the high released of fluorine. If the content of fluoride is well controlled, the PEO coating with MgF2phase is a promising surface modification of Mg alloys.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
Peng
P
Tian
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
Feng
F
Peng
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
Donghui
D
Wang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
Xuanyong
X
Liu
Mg alloy; corrosion resistance; cytocompatibility; fluoride