Reduction in OKT6 Positive Epidermal Langerhans Cells in Psoriasis.
Lengerhans cells (LC) were defined by indirect immunoperoxidast using OKT6 monoclonal antibody m the skin lesions of 10 untreated psoriasis patients. The distribution and the numbers of OKT6 + epidermal LC in the lesions was low in comparison to that found in the normal skin. In some of the lesions, T6 + LC could not be seen in the epidermis. This observation suggests that the reduction in LC may be a contributing factor in the pathogenesis of psoriasis.
R B
RB
Narayanan
B K
BK
Girdhar