Bilateral ovarian micrometastatic adenocarcinoma upon prophylactic oophorectomy concurrent with low anterior resection for rectal cancer.
BACKGROUND
This case report draws attention to the debated role of prophylactic oophorectomy in women undergoing definitive surgical resection of colon and rectal cancers. It can be challenging to discern the indications and appropriate patient population for this procedure based on the current literature. Potential benefits include treatment and prevention of metastatic disease, preventing development of primary ovarian cancer, and prolonging survival. Negative effects include an increase in operative time and potential morbidity, development of osteoporosis, the risk of cardiac events, and decreasing sexual function. Multiple patient factors such as age, menopausal status, patient preference, presence of hereditary conditions, exposure to radiation, site, and stage of disease should be considered.


METHODS
We present a case in which a premenopausal 49-year-old female underwent a prophylactic bilateral salpingo-oophorectomy concurrently with a low anterior resection following neoadjuvant chemoradiation for clinical stage III rectal cancer. On pathologic examination, resection margins and all 14 lymph nodes harvested were negative for malignancy. Interestingly, she was found to have micrometastatic adenocarcinoma in the bilateral ovaries which had appeared grossly normal at the time of surgery.


CONCLUSIONS
After consideration of the current literature, patient preference, and our clinical judgment, our patient ultimately had a therapeutic effect after undergoing prophylactic bilateral oophorectomy concurrently with a low anterior resection for rectal cancer. The addition of prophylactic oophorectomy in a select population, specifically women 50 years of age or younger and/or women who are in the premenopausal state, may carry a survival benefit in the setting of definitive surgical resection of colon and rectal cancers.
Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Three Cooper Plaza, Suite 403, Camden, NJ, 08103, USA. irons-robin@cooperhealth.edu.
Robin
http://orcid.org/0000-0001-5037-0470
R
Irons
Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Three Cooper Plaza, Suite 403, Camden, NJ, 08103, USA.
Erin
E
McIntosh
Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Three Cooper Plaza, Suite 403, Camden, NJ, 08103, USA.
Alexandre
A
Hageboutros
Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Three Cooper Plaza, Suite 403, Camden, NJ, 08103, USA.
David
D
Warshal
Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Three Cooper Plaza, Suite 403, Camden, NJ, 08103, USA.
Steven
S
McClane
D000230:Adenocarcinoma / Q000556:secondary / Q000601:surgery*; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D008875:Middle Aged; D061206:Neoplasm Micrometastasis; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D010052:Ovariectomy; D017697:Premenopause; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*
Colorectal cancer; Metastasis; Oophorectomy; Ovarian cancer; Prophylaxis