How do individuals cope with stress? Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish.
Despite the use of fish models to study human mental disorders and dysfunctions, knowledge of regional telencephalic responses in non-mammalian vertebrates expressing alternative stress coping styles is poor. As perception of salient stimuli associated with stress coping in mammals is mainly under forebrain limbic control, we tested region-specific forebrain neural (i.e. mRNA abundance and monoamine neurochemistry) and endocrine responses under basal and acute stress conditions for previously characterised proactive and reactive Atlantic salmon. Reactive fish showed a higher degree of the neurogenesis marker proliferating cell nuclear antigen (pcna) and dopamine activity under basal conditions in the proposed hippocampus homologue (Dl) and higher post-stress plasma cortisol levels. Proactive fish displayed higher post-stress serotonergic signalling (i.e. higher serotonergic activity and expression of the 5-HT1Areceptor) in the proposed amygdala homologue (Dm), increased expression of the neuroplasticity marker brain-derived neurotropic factor (bdnf) in both Dl and the lateral septum homologue (Vv), as well as increased expression of the corticotropin releasing factor 1 (crf1) receptor in the Dl, in line with active coping neuro-profiles reported in the mammalian literature. We present novel evidence of proposed functional equivalences in the fish forebrain with mammalian limbic structures.
Uni Environment, Uni Research AS, Bergen NO-5020, Norway marco.vindas@uni.no.|Department of Biosciences, University of Oslo, Oslo NO-0316, Norway.
Marco A
0000-0002-3996-0952
MA
Vindas
Radboud University, Institute for Water and Wetland Research, Department of Animal Ecology & Physiology, Nijmegen 6525 AJ, The Netherlands.
Marnix
M
Gorissen
National Institute of Aquatic Resources, Technical University of Denmark, Hirtshals DK-9850, Denmark.
Erik
E
Höglund
Radboud University, Institute for Water and Wetland Research, Department of Animal Ecology & Physiology, Nijmegen 6525 AJ, The Netherlands.
Gert
G
Flik
Uni Environment, Uni Research AS, Bergen NO-5020, Norway.
Valentina
V
Tronci
The University Centre of Svalbard, Longyearbyen NO-9171, Norway.|Nofima, Tromsø NO-9291, Norway.
Børge
B
Damsgård
Department of Neuroscience, Uppsala University, Uppsala SE-75124, Sweden.
Per-Ove
PO
Thörnqvist
Uni Environment, Uni Research AS, Bergen NO-5020, Norway.
Tom O
TO
Nilsen
Department of Neuroscience, Uppsala University, Uppsala SE-75124, Sweden.
Svante
S
Winberg
Department of Food Safety and Infection Biology, Norwegian University of Life Sciences, Oslo NO-0033, Norway.
Øyvind
Ø
Øverli
Uni Environment, Uni Research AS, Bergen NO-5020, Norway.
Lars O E
LOE
Ebbesson
D025041:Animal Migration; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D055495:Neurogenesis; D009473:Neuronal Plasticity; D010100:Oxygen / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D016548:Prosencephalon / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000378:metabolism; D020317:Salmo salar / Q000097:blood / Q000502:physiology*; D013312:Stress, Physiological; D014158:Transcription, Genetic
D019208:Brain-Derived Neurotrophic Factor; D018809:Proliferating Cell Nuclear Antigen; D012333:RNA, Messenger; D044282:Receptor, Serotonin, 5-HT1A; D010100:Oxygen; D006854:Hydrocortisone
Atlantic salmon; BDNF; Limbic areas; Neural plasticity; Serotonin