Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.
The stress-related neurohormones including glucocorticoids (GCs) are secreted by hair follicles (HFs), and GCs suppress murine hair growth in vivo. In this study, we found that dexamethasone (Dex), a synthetic GC, increased the expression of dickkopf-1 (DKK1), a known catagen inducer, in dermal papilla (DP) cells, but not in follicular keratinocytes. The neutralizing DKK1 antibody significantly attenuated the Dex-induced inhibition of human hair shaft elongation. In addition, the neutralizing Dkk1 antibody delayed Dex-induced catagen in mice. Collectively, our data strongly suggest that stress-related neurohormones cause DP cells to secrete DKK1, thereby leading to stress-associated disturbances in hair growth.
Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
Mi Hee
MH
Kwack
Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
Jun Ho
JH
Lee
Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
Chang Hoon
CH
Seo
Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
Jung Chul
JC
Kim
Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
Moon Kyu
MK
Kim
Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
Young Kwan
0000-0002-5122-4616
YK
Sung
D000818:Animals; D057134:Antibodies, Neutralizing / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D006197:Hair / Q000254:growth & development; D018859:Hair Follicle / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects / Q000502:physiology; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D015854:Up-Regulation
D057134:Antibodies, Neutralizing; C501126:DKK1 protein, human; C501127:Dkk1 protein, mouse; D005938:Glucocorticoids; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone
dermal papilla; dexamethasone; dickkopf 1; hair cycle; hair follicle