Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders.
Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders.
Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea. w1206@naver.com.
Yu Ri
YR
Woo
Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea. dingting@naver.com.
Sewon
S
Hwang
Institute of Clinical Medical Research, Yeouido St. Mary's Hostpital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea. cmcos@hanmail.net.
Seo Won
SW
Jeong
Department of Life Science, Sookmyung Women's University, Seoul 04310, Korea. cdhkor@sookmyung.ac.kr.
Dae Ho
DH
Cho
Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea. hjpark@catholic.ac.kr.
Hyun Jeong
HJ
Park
D000505:Alopecia / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D015415:Biomarkers; D016022:Case-Control Studies; D015536:Down-Regulation; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D018859:Hair Follicle / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
D015415:Biomarkers; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins; C583413:erythroid differentiation regulator 1, human
alopecia; erythroid differentiation regulator 1; hair loss; inflammation