A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested.
Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study (n = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved (p < 0.001) with all but 4 participants experiencing a benefit. An intestinal anti-inflammatory response was suggested. At 16-weeks follow-up while still on SSRI medications, the group had relapsed after cessation of the test intervention.
Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, Brisbane, QLD, 4006, Australia. m.bambling@uq.edu.au.
Matthew
M
Bambling
Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, Brisbane, QLD, 4006, Australia.
Sophie C
SC
Edwards
Medlab Clinical Ltd., Sydney, Australia.
Sean
S
Hall
Medlab Clinical Ltd., Sydney, Australia. luis_vitetta@medlab.co.|Sydney Medical School, The University of Sydney, Sydney, NSW, 2015, Australia. luis_vitetta@medlab.co.
Luis
http://orcid.org/0000-0002-7490-9298
L
Vitetta
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000928:Antidepressive Agents / Q000008:administration & dosage; D015331:Cohort Studies; D061218:Depressive Disorder, Treatment-Resistant / Q000175:diagnosis* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009963:Orotic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010865:Pilot Projects; D019936:Probiotics / Q000008:administration & dosage*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D000928:Antidepressive Agents; D009963:Orotic Acid; D017367:Selective Serotonin Reuptake Inhibitors; C104468:magnesium orotate
Depression; Inflammation; Intestinal dysbiosis; Magnesium orotate; Probiotics; SSRI; Treatment resistance