Gating of memory encoding of time-delayed cross-frequency MEG networks revealed by graph filtration based on persistent homology.
To explain gating of memory encoding, magnetoencephalography (MEG) was analyzed over multi-regional network of negative correlations between alpha band power during cue (cue-alpha) and gamma band power during item presentation (item-gamma) in Remember (R) and No-remember (NR) condition. Persistent homology with graph filtration on alpha-gamma correlation disclosed topological invariants to explain memory gating. Instruction compliance (R-hits minus NR-hits) was significantly related to negative coupling between the left superior occipital (cue-alpha) and the left dorsolateral superior frontal gyri (item-gamma) on permutation test, where the coupling was stronger in R than NR. In good memory performers (R-hits minus false alarm), the coupling was stronger in R than NR between the right posterior cingulate (cue-alpha) and the left fusiform gyri (item-gamma). Gating of memory encoding was dictated by inter-regional negative alpha-gamma coupling. Our graph filtration over MEG network revealed these inter-regional time-delayed cross-frequency connectivity serve gating of memory encoding.
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea.|Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, 110-744, Korea.|Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, 151-742, Korea.
Jarang
J
Hahm
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea.|Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, 110-744, Korea.
Hyekyoung
H
Lee
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea.|Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, 110-744, Korea.|Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, 151-742, Korea.|Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom.
Hyojin
H
Park
Department of Psychology, Kangwon National University, Chuncheon-si, 200-701, Korea.
Eunjoo
E
Kang
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea.|Data Science for Knowledge Creation Research Center, Seoul National University, Seoul, 151-742, Korea.|Department of Nuclear Medicine, Seoul National University Boramae Medical Center, 156-707, Seoul, Korea.
Yu Kyeong
YK
Kim
MEG Center, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, 110-744, Korea.
Chun Kee
CK
Chung
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea.|Data Science for Knowledge Creation Research Center, Seoul National University, Seoul, 151-742, Korea.
Hyejin
H
Kang
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea.|Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, 110-744, Korea.|Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, 151-742, Korea.|Data Science for Knowledge Creation Research Center, Seoul National University, Seoul, 151-742, Korea.|Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, 110-744, Korea.
Dong Soo
DS
Lee
D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008568:Memory; D057567:Memory, Long-Term; D008959:Models, Neurological; D013997:Time Factors