Automated detection of coarctation of aorta in neonates from two-dimensional echocardiograms.
Coarctation of aorta (CoA) is a critical congenital heart defect (CCHD) that requires accurate and immediate diagnosis and treatment. Current newborn screening methods to detect CoA lack both in sensitivity and specificity, and when suspected in a newborn, it must be confirmed using specialized imaging and expert diagnosis, both of which are usually unavailable at tertiary birthing centers. We explore the feasibility of applying machine learning methods to reliably determine the presence of this difficult-to-diagnose cardiac abnormality from ultrasound image data. We propose a framework that uses deep learning-based machine learning methods for fully automated detection of CoA from two-dimensional ultrasound clinical data acquired in the parasternal long axis view, the apical four chamber view, and the suprasternal notch view. On a validation set consisting of 26 CoA and 64 normal patients our algorithm achieved a total error rate of 12.9% (11.5% false-negative error and 13.6% false-positive error) when combining decisions of classifiers over three standard echocardiographic view planes. This compares favorably with published results that combine clinical assessments with pulse oximetry to detect CoA (71% sensitivity).
Philips Ultrasound Inc. , 3000 Minuteman Road, Andover, Massachusetts 02176, United States.
Franklin
F
Pereira
Boston Children's Hospital , Department of Cardiovascular Surgery, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Alejandra
A
Bueno
Boston Children's Hospital , Department of Cardiovascular Surgery, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Andrea
A
Rodriguez
Boston Children's Hospital , Department of Cardiovascular Surgery, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Douglas
D
Perrin
Boston Children's Hospital , Department of Cardiovascular Surgery, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Gerald
G
Marx
Philips Ultrasound Inc. , 3000 Minuteman Road, Andover, Massachusetts 02176, United States.
Michael
M
Cardinale
Philips Ultrasound Inc. , 3000 Minuteman Road, Andover, Massachusetts 02176, United States.
Ivan
I
Salgo
Boston Children's Hospital , Department of Cardiovascular Surgery, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Pedro
P
Del Nido
2-D ultrasound; coarctation of aorta; critical congenital heart disease; deep learning; feature extraction; neural networks