Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery.
A protein-stabilized multifunctional theranostic nanoplatform, gadolinium oxide-gold nanoclusters hybrid (Gd2O3-AuNCs), is constructed for multimodal imaging and drug delivery. The Gd2O3-AuNCs nanohybrid is developed by integrating Gd2O3nanocrystals and gold nanoclusters into bovine serum albumin scaffold as a stabilizer. The nanohybrid exhibits favorable biocompatibility and is capable of enhancing the contrast in magnetic resonance and X-ray computed tomography imaging. Meanwhile, the integrated AuNCs component not only endows the nanohybrid to produce red fluorescence, but also sensitizes the generation of singlet oxygen (1O2) upon near-infrared laser stimulation at 808 nm. Bovine serum albumin surrounding the nanoparticles makes Gd2O3-AuNCs a brilliant carrier for the delivery of indocyanine green (ICG). ICG loading endows the Gd2O3-AuNCs-ICG nanocomposite with a near-infrared fluorescence imaging capability, and improves its photodynamic property and photothermal capability. Ultimately, further experiments have demonstrated that Gd2O3-AuNCs-ICG nanocomposite is a promising theranostic agent for image guided cancer therapy.
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University , Box 332, Shenyang 110189, China.
Lu
L
Han
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University , Box 332, Shenyang 110189, China.
Jun-Mei
JM
Xia
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University , Box 332, Shenyang 110189, China.
Xin
X
Hai
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University , Box 332, Shenyang 110189, China.|Institute of Biotechnology, College of Life and Health Sciences, Northeastern University , Box H006, Shenyang 110189, China.
Yang
Y
Shu
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University , Box 332, Shenyang 110189, China.
Xu-Wei
http://orcid.org/0000-0001-7189-5022
XW
Chen
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University , Box 332, Shenyang 110189, China.
Jian-Hua
http://orcid.org/0000-0003-2175-3610
JH
Wang
D005682:Gadolinium / Q000737:chemistry*; D006046:Gold; D064847:Multimodal Imaging; D000068936:Theranostic Nanomedicine
C030581:gadolinium oxide; D006046:Gold; D005682:Gadolinium
X-ray computed tomography; gadolinium oxide; gold nanocluster; magnetic resonance imaging; near-infrared fluorescence; photothermal/photodynamic therapy