Exposure to phthalates is associated with lipid profile in peripubertal Mexican youth.
Animal models indicate that endocrine disrupting chemicals (EDCs) affect circulating lipid concentrations by interfering with hepatic fatty acid oxidation. Little is known of the relationship between EDC exposure and lipid profile in humans. We measured bisphenol A (BPA) and 9 phthalate metabolites in maternal urine collected at up to three time points during pregnancy as a measure of in utero exposure, and in the child's urine at 8-14 years as a measure of concurrent, peripubertal exposure among 248 participants of a Mexico City pre-birth cohort. We used linear regression to examine relations of BPA and phthalate exposure with peripubertal serum lipids, while also adjusting for child age, sex, and specific gravity. While in utero EDC exposure was not associated with lipid profile, higher concurrent levels of mono-3-carboxypropyl phthalate (MCPP), monoethyl phthalate (MEP), and dibutyl phthalate metabolites (DBP) corresponded with lower total cholesterol and low-density lipoprotein (LDL-C) in boys; e.g., an interquartile range increment in MCPP corresponded with 7.4% (2.0%, 12.8%) lower total cholesterol and 12.7% (3.8%, 21.6%) lower LDL-C. In girls, higher urinary di-2-ethylhexyl phthalate metabolites (ΣDEHP) correlated with lower LDL-C (-7.9% [-15.4%, -0.4%]). Additional longitudinal research is needed to determine whether these associations persist beyond adolescence.
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address: perngwei@umich.edu.
Wei
W
Perng
Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Deborah J
DJ
Watkins
Center for Nutrition and Health Research, National Institute of Public Health, Mexico City, MX.
Alejandra
A
Cantoral
Center for Nutrition and Health Research, National Institute of Public Health, Mexico City, MX.
Adriana
A
Mercado-García
Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
John D
JD
Meeker
Center for Nutrition and Health Research, National Institute of Public Health, Mexico City, MX.
Martha Maria
MM
Téllez-Rojo
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Karen E
KE
Peterson
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D052244:Endocrine Disruptors / Q000652:urine*; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D008800:Mexico; D010795:Phthalic Acids / Q000009:adverse effects* / Q000652:urine*; D011247:Pregnancy; D011627:Puberty; D055815:Young Adult
D015415:Biomarkers; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D008055:Lipids; D010795:Phthalic Acids; C032279:phthalic acid
Bisphenol A (BPA); Lipids; Pediatric population; Peripuberty; Phthalates