Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects.
A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells.
Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany. judith.mayr@chemie.uni-regensburg.de.
Judith
J
Mayr
Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany. bachl_j@web.de.
Jürgen
J
Bachl
Institut für Pharmazie, Pharmakologie und Toxikologie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany. jens.schlossmann@chemie.uni-regensburg.de.
Jens
J
Schlossmann
Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany. david.diaz@chemie.uni-regensburg.de.|Institute of Advanced Chemistry of Catalonia-Spanish National Research Council (IQAC-CSIC), Jordi Girona 18-26, Barcelona 08034, Spain. david.diaz@chemie.uni-regensburg.de.
David Díaz
DD
Díaz
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D006461:Hemolysis; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011073:Polyamines / Q000737:chemistry*; D000071228:Polyelectrolytes; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers; D000644:Quaternary Ammonium Compounds
antimicrobial polymer; hemolysis; ionenes; polycations; quaternary ammonium; topomers