Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds.
Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract. As a result, H. erinaceus powder was found to increase fecal lipid levels in excreted matter. Further in vitro investigation showed that ethanol extract inhibited the activity of lipase, and four lipase-inhibitory compounds were isolated from the extract: hericenone C, hericenone D, hericenone F, and hericenone G. In short, we suggest that H. erinaceus has an anti-obesity effect during menopause because it decreases the ability to absorb lipids.
Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Eri
E
Hiraki
Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Shoko
S
Furuta
Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Rika
R
Kuwahara
Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Naomichi
N
Takemoto
Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Toshiro
T
Nagata
Center for Advanced Instrumental and Educational Supports, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Taiki
T
Akasaka
Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, 6-10-1, Hakozaki, Higashi-Ku, 812-8581, Fukuoka, Japan.
Bungo
B
Shirouchi
Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, 6-10-1, Hakozaki, Higashi-Ku, 812-8581, Fukuoka, Japan.
Masao
M
Sato
Department of Biological and Environmental Chemistry, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka, 820-8555, Japan.
Koichiro
K
Ohnuki
Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan. shimizu@agr.kyushu-u.ac.jp.
Kuniyoshi
http://orcid.org/0000-0003-3803-6060
K
Shimizu
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D005260:Female; D020738:Leptin / Q000097:blood; D008049:Lipase / Q000037:antagonists & inhibitors; D050356:Lipid Metabolism / Q000187:drug effects*; D008593:Menopause; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism*; D010052:Ovariectomy; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D011208:Powders
D019440:Anti-Obesity Agents; D001688:Biological Products; D020738:Leptin; D010636:Phenols; D011208:Powders; C532216:hericenone C; C532217:hericenone D; D002784:Cholesterol; D008049:Lipase
Anti-obesity; Hericenone; Hericium erinaceus; Menopause; Pancreatic lipase inhibition