Hepatitis and thrombocytopenia: markers of dengue mortality.
Dengue fever is of great concern to public health in India as it contributes significantly to the burden of healthcare. The aim of our study was to measure mortality in dengue and its association with hepatitis and thrombocytopenia. Our study was performed in a tertiary care setting in the state of Kerala in southern India. Adult patients admitted in the year 2013 were included. Among 1308 confirmed dengue patients, the mortality rate was 1.76%. Hepatitis and thrombocytopenia were present in over 80% of all patients, but severe hepatitis was seen in 11.4% and severe thrombocytopenia in 9.3%. These were markers of fatal outcome. Other factors significantly associated with mortality were age >60 years, male sex, diabetes and the presence of any co-morbidity.
1 Assistant Professor of Medicine, Department of Medicine, Malankara Orthodox Syrian Church Medical College and Hospital, Kolenchery, Kerala, India.
Smitha
S
Krishnamoorthy
2 Assistant Professor of Community Medicine, Department of Community Medicine, Malankara Orthodox Syrian Church Medical College and Hospital, Kolenchery, Kerala, India.
Arun N
AN
Bhatt
3 Associate Professor of Statistics, Malankara Orthodox Syrian Church Medical College and Hospital, Kolenchery, Kerala, India.
Celine Thalappillil
CT
Mathew
4 Professor of Medicine, Department of Medicine, Malankara Orthodox Syrian Church Medical College and Hospital, Kolenchery, Kerala, India.
Abraham M
AM
Ittyachen
D000328:Adult; D017677:Age Distribution; D000368:Aged; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003715:Dengue / Q000150:complications / Q000401:mortality*; D005260:Female; D006506:Hepatitis A / Q000150:complications / Q000453:epidemiology*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D063128:Tertiary Health Care / Q000706:statistics & numerical data; D013921:Thrombocytopenia / Q000150:complications / Q000453:epidemiology*
Dengue; hepatitis; mortality in dengue; severe dengue; thrombocytopenia; transaminase levels