Bidentate iminodiacetate modified dendrimer for bone imaging.
A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite, calcium oxalate and calcium phosphate salts. In mice, the probe offered vivid skeletal details after intravenous delivery.
Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA.
Lara
L
Pes
Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology, Chonnam National University Medical School, 671, Jebongno, Dong-Gu, Gwangju 501-757, Republic of Korea.
Young
Y
Kim
Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: cht2018@med.cornell.edu.
Ching-Hsuan
CH
Tung
D061605:Administration, Intravenous; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D050091:Dendrimers / Q000737:chemistry*; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000737:chemistry*; D007098:Imino Acids / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D011107:Polylysine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D050091:Dendrimers; D005456:Fluorescent Dyes; D007098:Imino Acids; D011107:Polylysine
Bone; Dendrimer; Fluorescence imaging; Hydroxyapatite; Iminodiacetate