Sesquiterpene lactones from Elephantopus mollis and their anti-inflammatory activities.
Seven sesquiterpene lactones, 8-O-methacryloylelephanpane, 2,4-bis-O-methyl-8-O-methacryloylelephanpane, 4-O-ethyl-8-O-methacryloylelephanpane, 8-O-methacryloylisoelephanpane, 2-O-demethyltomenphantopin C, molephantin A, molephantin B, along with ten known ones, were isolated from Elephantopus mollis (Asteraceae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolates were evaluated for their anti-inflammatory activities on LPS-stimulated RAW 264.7 cells, and all tested compounds exhibited potent anti-inflammatory effects with IC50values of 0.57 ± 0.17 to 14.34 ± 1.61 μM, except that compound tomenphantopin C exhibited moderate anti-inflammatory activity with IC50values of 59.97 ± 1.53 μM.
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Zhong-Nan
ZN
Wu
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Yu-Bo
YB
Zhang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Neng-Hua
NH
Chen
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Mo-Jiao
MJ
Li
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Man-Mei
MM
Li
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Wei
W
Tang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Ling
L
Zhuang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tliyl@jnu.edu.cn.
Yao-Lan
YL
Li
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: twangguocai@jnu.edu.cn.
Guo-Cai
GC
Wang
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D019659:Asteraceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D000067996:RAW 264.7 Cells; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012717:Sesquiterpenes
Anti-inflammatory activity; Asteraceae; Elephantopus mollis; Sesquiterpene lactones