The pharmacokinetics of oral ketoprofen in patients after gastric resection.
BACKGROUND
Total and partial gastric resection may affect the pharmacokinetics of drugs, especially orally administered a few days after surgery. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) broadly used to treat postoperative pain, including patients after gastric resection. The aim of the research was to analyse the pharmacokinetics (PK) of orally administered ketoprofen in patients after gastrectomy.


METHODS
The research was carried out on two groups of patients after total (TG; Roux-Y procedure) and partial (PG; Billroth II procedure) gastrectomy. The patients in group TG (n=15; mean [SD] age 61.86 [14.15] years; and BMI 24.20 [3.73] kg/m2) and group PG (n=5; mean [SD] age 62.40 [16.80] years; and BMI 23.98 [3.45] kg/m2) received ketoprofen in a single oral dose of 100mg. The measurement of ketoprofen plasma concentrations was made by means of the HPLC (high performance liquid chromatography) method.


RESULTS
The PK parameters in group TG and PG were as follows: maximum plasma concentration (Cmax), 3.42 [0.99] and 4.66 [0.81] mg/l (p=0.0220); area under the plasma concentration-time curve from zero to infinity (AUC0-∞), 9.12 [2.78] and 9.17 [2.87] mg×h/ml (p=0.9734); area under the first moment curve from zero to the time of infinity (AUMC0-∞), 25.95 [8.52] and 26.53 [11.43] mg×h2/l (p=0.9056); time to reach maximum concentration (tmax), 0.47 [0.25] and 0.55 [0.27] h (p=0.5327), respectively.


CONCLUSIONS
Lower concentrations of ketoprofen in patients after gastrectomy suggest that it might be necessary to apply higher dose of the analgesic.
Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, Poznań, Poland. Electronic address: joanna.porazka@gmail.com.
Joanna
J
Porażka
Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Agnieszka
A
Karbownik
1st Department of Surgical Oncology and General Surgery, Wielkopolska Cancer Centre, Poznań, Poland; College of Health, Beauty Care and Education, Faculty of Cosmetology and Educational Sciences, Poznań, Poland.
Dawid
D
Murawa
1st Department of Surgical Oncology and General Surgery, Wielkopolska Cancer Centre, Poznań, Poland.
Arkadiusz
A
Spychała
Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Magdalena
M
Firlej
Polpharma Biologics, Gdańsk, Poland.
Tomasz
T
Grabowski
1st Department of Surgical Oncology and General Surgery, Wielkopolska Cancer Centre, Poznań, Poland.
Paweł
P
Murawa
Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Edmund
E
Grześkowiak
Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Edyta
E
Szałek
D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D005260:Female; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D007660:Ketoprofen / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen
Ketoprofen; Partial gastrectomy; Pharmacokinetics; Total gastrectomy