Enhanced corrosion resistance and cytocompatibility of biodegradable Mg alloys by introduction of Mg(OH)2particles into poly (L-lactic acid) coating.
A strategy of suppressing the fast degradation behaviour of Mg-based biomaterials by the introduction of one of Mg degradation products Mg(OH)2was proposed according to the following degradation mechanism, Mg + 2H2O ⇋ Mg(OH)2+ H2↑. Specifically, Mg(OH)2submicron particles were mixed into poly (L-lactic acid) (PLLA) to synthesize a composite coating onto hydrofluoric acid-pretreated Mg-Nd-Zn-Zr alloy. The in vitro degradation investigations showed that the addition of Mg(OH)2particles not only slowed down the corrosion of Mg matrix, but also retarded the formation of gas pockets underneath the polymer coating. Correspondingly, cytocompatibility results exhibited significant improvement of proliferation of endothelial cells, and further insights was gained into the mechanisms how the introduction of Mg(OH)2particles into PLLA coating affected the magnesium alloy degradation and cytocompatibility. The present study provided a promising surface modification strategy to tailor the degradation behaviour of Mg-based biomaterials.
National Engineering Research Centre of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
Yong-Juan
YJ
Shi
National Engineering Research Centre of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
Jia
J
Pei
National Engineering Research Centre of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
Jian
J
Zhang
National Engineering Research Centre of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
Jia-Lin
JL
Niu
National Engineering Research Centre of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
Hua
H
Zhang
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Sheng-Rong
SR
Guo
Microport Endovascular (Shanghai) Co., Ltd, Shanghai, 201318, China.
Zhong-Hua
ZH
Li
National Engineering Research Centre of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
Guang-Yin
GY
Yuan
D000497:Alloys / Q000737:chemistry; D001669:Biochemical Phenomena; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D049109:Cell Proliferation; D002470:Cell Survival; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003343:Corrosion; D042783:Endothelial Cells; D006801:Humans; D008274:Magnesium / Q000737:chemistry; D008276:Magnesium Hydroxide / Q000737:chemistry; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry; D013499:Surface Properties
D000497:Alloys; D020099:Coated Materials, Biocompatible; D011091:Polyesters; C033616:poly(lactide); D008274:Magnesium; D008276:Magnesium Hydroxide