Tolerance development in food protein-induced allergic proctocolitis: Single centre experience.
BACKGROUND
Food protein-induced allergic proctocolitis (FPIAP) is characterised by inflammation of the distal colon in response to one or more food proteins. It is a benign condition of bloody stools in a well-appearing infant, with usual onset between one and four weeks of age.


OBJECTIVE
Our objective was to examine the clinical properties of patients with FPIAP, tolerance development time as well as the risk factors that affect tolerance development.


METHODS
The clinical symptoms, offending factors, laboratory findings, methods used in the diagnosis and tolerance development for 77 patients followed in the Paediatric Allergy and Gastroenterology Clinics with the diagnosis of FPIAP during January 2010-January 2015 were examined in our retrospective cross-sectional study.


RESULTS
The starting age of the symptoms was 3.3±4.7 months (0-36). Milk was found as the offending substance for 78% of the patients, milk and egg for 13% and egg for 5%. Mean tolerance development time of the patients was 14.7±11.9 months (3-66 months). Tolerance developed before the age of one year in 40% of the patients. Tolerance developed between the age of 1-2 years in 27%, between the age of 2-3 years in 9% and after the age of 3 years in 5% of the patients.


CONCLUSIONS
Smaller onset age and onset of symptoms during breastfeeding were found associated with early tolerance development. In the majority of the patients, FPIAP resolves before the age of one year, however in some of the patients this duration may be much longer.
Dr Behcet Uz Children's Hospital, Pediatric Allergy and Immunology, Izmir, Turkey.
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Erdem
Dr Behcet Uz Children's Hospital, Pediatric Allergy and Immunology, Izmir, Turkey. Electronic address: tekin212@gmail.com.
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Nacaroglu
Dr Behcet Uz Children's Hospital, Pediatric Allergy and Immunology, Izmir, Turkey.
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Karaman
Dr Behcet Uz Children's Hospital, Pediatric Gastroenterology, Izmir, Turkey.
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Erdur
Dr Behcet Uz Children's Hospital, Pediatric Allergy and Immunology, Izmir, Turkey.
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Karkıner
Dr Behcet Uz Children's Hospital, Pediatric Allergy and Immunology, Izmir, Turkey.
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Can
D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications*; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011350:Proctocolitis / Q000276:immunology*; D012189:Retrospective Studies; D012307:Risk Factors
Food allergy; Food protein-induced allergic proctocolitis; Non-IgE mediated food allergy