Retrieval of high-fidelity memory arises from distributed cortical networks.
Medial temporal lobe (MTL) function is well established as necessary for memory of facts and events. It is likely that lateral cortical regions critically guide cognitive control processes to tune in high-fidelity details that are most relevant for memory retrieval. Here, convergent results from functional and structural MRI show that retrieval of detailed episodic memory arises from lateral cortical-MTL networks, including regions of inferior frontal and angular gyrii. Results also suggest that recognition of items based on low-fidelity, generalized information, rather than memory arising from retrieval of relevant episodic details, is not associated with functional connectivity between MTL and lateral cortical regions. Additionally, individual differences in microstructural properties in white matter pathways, associated with distributed MTL-cortical networks, are positively correlated with better performance on a mnemonic discrimination task.
Department of Neurology & Center for Integrative Neurosciences, University of California, San Francisco, United States. Electronic address: peter.wais@ucsf.edu.
Peter E
PE
Wais
Department of Neurology & Center for Integrative Neurosciences, University of California, San Francisco, United States.
Sahar
S
Jahanikia
Department of Neurology & Center for Integrative Neurosciences, University of California, San Francisco, United States.
Daniel
D
Steiner
Center for the Neurobiology of Learning and Memory & Department of Neurobiology and Behavior, University of California, Irvine, United States.
Craig E L
CEL
Stark
Department of Neurology & Center for Integrative Neurosciences, University of California, San Francisco, United States; Departments of Physiology and Psychiatry, University of California, San Francisco, United States.
Adam
A
Gazzaley
D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D061212:Memory, Episodic; D009434:Neural Pathways / Q000502:physiology*; D055815:Young Adult
Cognitive control; Episodic retrieval; Functional networks; Mnemonic discrimination; fMRI