Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials.
Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal-chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal-chelating β-cyclodextrin polymer bearing 8-hydroxyquinoline ligands. The metal ions (Cu2+or Zn2+) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self- and metal-induced Aβ aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble β-cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials.
Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy.|Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B, Unit of Catania, Viale A. Doria 6, 95125, Catania, Italy.
Valentina
http://orcid.org/0000-0001-7603-4790
V
Oliveri
Istituto di Biostrutture e Bioimmagini, CNR, Via P. Gaifami 18, 95126, Catania, Italy.
Francesco
F
Bellia
Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy.
Graziella
http://orcid.org/0000-0001-8305-081X
G
Vecchio
D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism; D000975:Antioxidants / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry*; D000067493:Dynamic Light Scattering; D006912:Hydroxyquinolines / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D009391:Nephelometry and Turbidimetry; D010316:Particle Size; D066329:Protein Aggregates / Q000187:drug effects; D013053:Spectrophotometry; D015032:Zinc / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D001672:Biocompatible Materials; D003505:Cyclodextrins; D006912:Hydroxyquinolines; D008024:Ligands; D066329:Protein Aggregates; D047392:beta-Cyclodextrins; D003300:Copper; D015032:Zinc; C031215:betadex
antiaggregant; antioxidant; copper; polymer; zinc