Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development.
Recent literature highlights that ozone therapy could be considered a viable adjuvant therapy in oncological patients receiving radio-chemotherapy. The use of ozone therapy in these patients enhances the action of chemotherapy and at the same time reduces side-effects, such as nausea, vomiting, opportunistic infections, buccal ulcers, hair loss and fatigue. Such positive therapeutic effects of ozone therapy can cause a larger physical and mental wellbeing resulting in improved quality of life. This work reviews the recent acquisition of scientific knowledge regarding the ozone therapy and highlights the molecular and cellular pathways involved.
Department of Anesthesiological, Surgical and Emergency Sciences, University of Campania, Naples, Italy margluon@gmail.com.
Margherita
M
Luongo
Department of Anesthesiological, Surgical and Emergency Sciences, University of Campania, Naples, Italy.
Anna Lisa
AL
Brigida
Department of Anesthesiological, Surgical and Emergency Sciences, University of Campania, Naples, Italy.
Luigi
L
Mascolo
Department of Anesthesiological, Surgical and Emergency Sciences, University of Campania, Naples, Italy.
Gennaro
G
Gaudino
D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects*; D059186:Chemoradiotherapy, Adjuvant; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010126:Ozone / Q000627:therapeutic use*
D010126:Ozone
HIF; Ozone; hypoxia; review; tumor