IgG4-positive cell infiltration in various cardiovascular disorders - results from histopathological analysis of surgical samples.
The diagnosis of Immunoglobulin G4 (IgG4)-related disease (IgG4-RD), in general, depends on serum IgG4 concentrations and histopathological findings; therefore, diagnosis of IgG4-RD in cardiovascular organs/tissues is often difficult owing to the risk of tissue sampling.



Prevalence of IgG4-positive lymphoplasmacytic infiltration in 103 consecutive cardiovascular surgical samples from 98 patients with various cardiovascular diseases was analyzed immunohistochemically.



The diagnoses of the enrolled patients included aortic aneurysm (abdominal, n = 8; thoracic, n = 9); aortic dissection (n = 20); aortic stenosis (n = 24), aortic regurgitation (n = 10), and mitral stenosis/regurgitation (n = 17). In total, 10 (9.7%) of the 103 specimens showed IgG4-positive cell infiltration with various intensities; five of these were aortic valve specimens from aortic stenosis, and IgG4-positive cell infiltration was present at >10 /HPF in three of them. In one aortic wall sample from an abdominal aortic aneurysm, various histopathological features of IgG4-RD, such as IgG4-positive cell infiltration, obliterating phlebitis, and storiform fibrosis, were observed.



IgG4-positive cell infiltration was observed in 9.7% of the surgical cardiovascular specimens, mainly in the aortic valve from aortic stenosis and in the aortic wall from aortic aneurysm. Whether IgG4-positive cell infiltration has pathophysiological importance in the development or progression of cardiovascular diseases should be investigated in future studies.
Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
Ryoto
R
Hourai
Department of Pathology, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan.
Satomi
S
Kasashima
Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
Koichi
K
Sohmiya
Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
Yohei
Y
Yamauchi
Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan.
Hideki
H
Ozawa
Department of Pathology, Osaka Medical College, Osaka, Japan.
Yoshinobu
Y
Hirose
Department of Pathology, Osaka Medical College, Osaka, Japan.
Yasuhiro
Y
Ogino
Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan.
Takahiro
T
Katsumata
Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan.
Masahiro
M
Daimon
Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
Shu-Ichi
SI
Fujita
Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
Masaaki
M
Hoshiga
Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan. ishizaka@osaka-med.ac.jp.
Nobukazu
N
Ishizaka
D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000276:immunology / Q000473:pathology; D001014:Aortic Aneurysm / Q000276:immunology / Q000473:pathology; D001021:Aortic Valve / Q000276:immunology / Q000473:pathology; D001024:Aortic Valve Stenosis / Q000276:immunology / Q000473:pathology; D001027:Aortography / Q000379:methods; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D002634:Chemotaxis, Leukocyte; D000072226:Computed Tomography Angiography; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology* / Q000473:pathology
D015415:Biomarkers; D007074:Immunoglobulin G
Aortic aneurysm; Aortic stenosis; Aortic valve; Aortic wall; IgG4-related disease