Metformin-SGLT2, Dehydration, and Acidosis Potential.
Clinicians are aware of the risks and benefits of metformin in type 2 diabetes. In geriatric populations lactic acidosis due to diminishing kidney function is an issue. The recent addition of a group of agents to control diabetes through increased glycosuria may increase the risk of dehydration and acidosis. This may happen due to gastrointestinal loss from metformin diarrhea or urine loss from diuretics. A typical example is presented.
Kidney and Hypertension Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
John A
JA
D'Elia
Kidney and Hypertension Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.|Department of Pharmacy Practice, MCPHS University, Boston, Massachusetts.
Alissa R
AR
Segal
Kidney and Hypertension Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Larry A
LA
Weinrauch
D000140:Acidosis, Lactic / Q000209:etiology*; D000369:Aged, 80 and over; D003681:Dehydration / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors
D007004:Hypoglycemic Agents; D008687:Metformin
SGLT-2 inhibitors; acidosis; dehydration; metformin