Interleukin-11 induces preterm birth and modulates decidual inflammasome gene expression in mice.
Decidual inflammation and inflammasome activation contribute to the pathogenesis of preterm birth (PTB). Interleukin-(IL)11 exerts complex regulatory effects on inflammation and IL-11 protein is elevated in PTB decidua. We aimed to determine a functional role for IL-11 in parturition or PTB. IL-11 administration during middle-late gestation pregnancy induced preterm birth in 87.5% of mice versus saline controls. Litters from IL-11-treated mothers had reduced offspring weight and numbers of live pups. IL-11 up-regulated decidual gene expression of key components of the inflammasome including IL-1β, Caspase-1 and ASC. This is the first report of a causal role for IL-11 in PTB in vivo.
Embryo Implantation Laboratory, Hudson Institute, Clayton, VIC, Australia; Department of Molecular and Translational Medicine, Monash University, Clayton, VIC, Australia.
Amy
A
Winship
Embryo Implantation Laboratory, Hudson Institute, Clayton, VIC, Australia; Department of Molecular and Translational Medicine, Monash University, Clayton, VIC, Australia; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia. Electronic address: evdokia.dimitriadis@hudson.org.au.
Evdokia
E
Dimitriadis
D000818:Animals; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics / Q000378:metabolism; D020170:Caspase 1 / Q000235:genetics / Q000378:metabolism; D003656:Decidua / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D058847:Inflammasomes / Q000235:genetics* / Q000378:metabolism; D017370:Interleukin-11 / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D008098:Litter Size / Q000187:drug effects; D051379:Mice; D011247:Pregnancy; D047928:Premature Birth / Q000139:chemically induced*
D053468:CARD Signaling Adaptor Proteins; D058847:Inflammasomes; D017370:Interleukin-11; D053583:Interleukin-1beta; C498534:Pycard protein, mouse; D020170:Caspase 1
Cytokines; Decidua; Inflammasome; Pregnancy