Antibiotic Trends Amid Multidrug-Resistant Gram-Negative Infections in Intensive Care Units.
Isolates from ICUs most commonly find multidrug-resistant (MDR) gram-negative bacteria. The purpose of this article is to discuss the significant impact MDR gram-negative infections are having on ICUs, the threat on health and mortality, and effective and new approaches aimed to combat MDR gram-negative infections in critically ill populations. Inappropriate antibiotic therapies for suspected or documented infections are the leading cause of the emergence of bacterial resistance. A variety of strategies are aimed at combatting this international burden via antibiotic stewardship programs. Studies are demonstrating promise against the virulence MDR gram-negative infections have posed.
School of Nursing, Louisiana State University Health Sciences Center, 1900 Gravier Street, New Orleans, LA 70112, USA. Electronic address: lfowle@lsuhsc.edu.
Leanne H
LH
Fowler
School of Nursing, Louisiana State University Health Sciences Center, 1900 Gravier Street, New Orleans, LA 70112, USA.
Susan
S
Lee
D016638:Critical Illness / Q000401:mortality; D003428:Cross Infection / Q000382:microbiology* / Q000401:mortality / Q000517:prevention & control; D024901:Drug Resistance, Multiple, Bacterial; D004363:Drug Utilization / Q000592:standards / Q000639:trends*; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology* / Q000401:mortality / Q000517:prevention & control; D006801:Humans; D057970:Inappropriate Prescribing / Q000009:adverse effects; D007362:Intensive Care Units; D012307:Risk Factors
Antibiotic resistance; Gram-negative bacteria; ICU; Multidrug-resistant