Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia.
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methylation studies have highlighted an important role of dysregulated methylation signature in AML from biological and clinical standpoint. In this review, we will outline the recent advances in the methylome study of AML and overview the impacts of DNA methylation on AML diagnosis, treatment, and prognosis.
Department of Hematology and BMT center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.|Department of Hematology, Hainan Branch of Chinese PLA General Hospital, Sanya, 572013, Hainan Province, China.
Yan
Y
Li
Department of Hematology and BMT center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.|Medical school of Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Qingyu
Q
Xu
Department of Hematology and BMT center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Na
N
Lv
Department of Hematology and BMT center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Lili
L
Wang
Annoroad Gene Technology Co. Ltd, Beijing, 100176, China.
Hongmei
H
Zhao
Annoroad Gene Technology Co. Ltd, Beijing, 100176, China.
Xiuli
X
Wang
Annoroad Gene Technology Co. Ltd, Beijing, 100176, China.
Jing
J
Guo
Annoroad Gene Technology Co. Ltd, Beijing, 100176, China.
Chongjian
C
Chen
Department of Hematology and BMT center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Yonghui
Y
Li
Department of Hematology and BMT center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. liyu301@vip.163.com.
Li
L
Yu
D000066491:Clinical Decision-Making; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000235:genetics*; D044127:Epigenesis, Genetic; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis
D004273:DNA, Neoplasm
Acute myeloid leukemia; Clinical implications; DNA methylation