Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite.
The organic-inorganic bioceramic composite microneedles (MNs) were prepared from hydroxyapatite (Hap) and gelatin (Gel) via a template method. The resultant hydroxyapatite and gelatin composite MNs exhibited low cytotoxicity and excellent mechanical properties. After transdermal administration to the diabetic rats, the insulin could be released from bioceramic composite MNs. An obvious and effective hypoglycemic effect could be obtained compared with that of subcutaneous injection route. This work suggests that bioceramic composite MNs containing of insulin have a potential application in diabetes treatment via transdermal ingestion.
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China.
Weijiang
W
Yu
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China; National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou 310018, China; Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou 310018, China. Electronic address: ghjiang_cn@zstu.edu.cn.
Guohua
G
Jiang
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China.
Depeng
D
Liu
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China.
Lei
L
Li
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China; National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou 310018, China; Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou 310018, China.
Zaizai
Z
Tong
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China; National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou 310018, China; Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou 310018, China.
Juming
J
Yao
College of Life Science, Zhejiang Sci Tech University, Hangzhou 310018, China.
Xiangdong
X
Kong
D000279:Administration, Cutaneous; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D002516:Ceramics / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D017886:Durapatite / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D009339:Needles; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D001786:Blood Glucose; D007328:Insulin; D005780:Gelatin; D017886:Durapatite
Bioceramic; Hypoglycemic effect; Insulin; Microneedles; Transdermal delivery