Quantitative analysis of gadoxetic acid-enhanced magnetic resonance imaging predicts histological grade of hepatocellular carcinoma.
OBJECTIVE
To confirm the histological grade of hepatocellular carcinoma (HCC) by gadoxetic acid-enhanced MRI.


METHODS
Ninety-five HCC patients underwent gadoxetic acid-enhanced MRI before surgical intervention. The correlations among the signal absolute enhancement, contrast enhancement ratio (CER) and tumor histological grade were analyzed.


RESULTS
The correlation between CER of tumor-to-liver and the grades of tumor differentiation is the most significant negative. The k-value for the CER of tumor-to-liver and histopathologic analysis is 0.62, which gives evidence of good agreement.


CONCLUSIONS
The quantitative analysis of gadoxetic acid-enhanced MRI can predict the histological grades of small HCCs.
Department of Hepatobiliary Surgery, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510282, China. Electronic address: tonghongfei@sina.com.
Hong-Fei
HF
Tong
Department of Hepatobiliary Surgery, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510282, China.
Hong-Bo
HB
Liang
Department of Hepatobiliary Surgery, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510282, China.
Zhi-Kang
ZK
Mo
Department of Hepatobiliary Surgery, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510282, China.
Tian-Pei
TP
Guan
Department of Hepatobiliary Surgery, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510282, China.
Jian
J
Yang
Department of Hepatobiliary Surgery, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510282, China. Electronic address: fangch_dr@163.com.
Chi-Hua
CH
Fang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012680:Sensitivity and Specificity
D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
Gd-EOB-DTPA; Hepatocellular carcinoma; Histological grade; MRI; Quantitative analysis