A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS.
Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)-infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non-proliferating resting cells. SIV-infected non-proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
Bapi
B
Pahar
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
Wendy
W
Lala
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
Dot
D
Kuebler
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
David
D
Liu
D000818:Animals; D003713:Dendritic Cells / Q000821:virology; D004660:Encephalitis / Q000503:physiopathology / Q000662:veterinary / Q000821:virology; D008253:Macaca mulatta; D008264:Macrophages / Q000821:virology; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000503:physiopathology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D013601:T-Lymphocytes / Q000821:virology
T cells; infection; macrophage; reservoir; resting cells; simian immunodeficiency virus; simian immunodeficiency virus RNA