Interplay between renal endothelin and purinergic signaling systems.
Alterations in extracellular fluid volume regulation and sodium balance may result in the development and maintenance of salt-dependent hypertension, a major risk factor for cardiovascular disease. Numerous pathways contribute to the regulation of sodium excretion and blood pressure, including endothelin and purinergic signaling. Increasing evidence suggests a link between purinergic receptor activation and endothelin production within the renal collecting duct as a means of promoting natriuresis. A better understanding of the relationship between these two systems, especially in regard to sodium homeostasis, will fill a significant knowledge gap and may provide novel antihypertensive treatment options. Therefore, this review focuses on the cross talk between endothelin and purinergic signaling as it relates to the renal regulation of sodium and blood pressure homeostasis.
Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama emangohar@uabmc.edu.
Eman Y
EY
Gohar
Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Malgorzata
M
Kasztan
Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
David M
DM
Pollock
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D019332:Endothelin-1 / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D007685:Kidney Tubules, Collecting / Q000378:metabolism* / Q000503:physiopathology; D009318:Natriuresis; D017466:Receptors, Endothelin / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D015398:Signal Transduction; D012982:Sodium, Dietary / Q000097:blood / Q000378:metabolism* / Q000652:urine
D019332:Endothelin-1; D017466:Receptors, Endothelin; D018048:Receptors, Purinergic P2; D012982:Sodium, Dietary; D000255:Adenosine Triphosphate
Sodium; blood pressure; kidney; natriuresis