Effects of TiO2nanoparticles at predicted environmental relevant concentration on the marine scallop Chlamys farreri: An integrated biomarker approach.
Manufactured nanoparticles (NPs) have caused extensive concern about their toxic effects on the marine environment. However, the chronic toxicity of NPs at predicted environmental relevant concentration on the marine organisms is poorly understood. In this study, we investigated the oxidative stress, neurotoxicity and histopathological effects of TiO2NPs at predicted environmental relevant concentration (1mg/L) to marine scallop Chlamys farreri. The results showed that TiO2NPs caused obviously oxidative damage on the scallops as evidenced by the significantly elevated superoxide dismutase (SOD), catalase (CAT) activities and malondialdehyde (MDA) contents. The increased acetylcholine esterase (AChE) activities reflected neurotoxicity of TiO2NPs. The histopathological analysis revealed alterations in the gill and digestive gland, such as dysplastic and necrosis. Additionally, integrated biomarker response (IBR) values indicated that TiO2NPs can cause strong toxic effects on the scallop. These results suggested that predicted environmental relevant TiO2NPs can cause adverse effects on scallops and IBR analysis can be used as an effective approach for risk assessment of NPs on the marine organisms.
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China. Electronic address: xiabin@ysfri.ac.cn.
Bin
B
Xia
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.
Lin
L
Zhu
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
Qian
Q
Han
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.
Xuemei
X
Sun
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.
Bijuan
B
Chen
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.
Keming
K
Qu
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D004784:Environmental Monitoring; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D049897:Pectinidae / Q000187:drug effects* / Q000201:enzymology; D014025:Titanium / Q000633:toxicity*; D036401:Toxicity Tests, Chronic; D014874:Water Pollutants, Chemical / Q000633:toxicity
D015415:Biomarkers; D014874:Water Pollutants, Chemical; C009495:titanium dioxide; D014025:Titanium; D000110:Acetylcholinesterase
Histopathological alteration; IBR analysis; Marine scallop; Neurotoxicity; Oxidative stress; TiO(2) nanoparticles