Systematic probing of the bacterial RNA structurome to reveal new functions.
RNA folds into intricate structures. Recent discoveries using next-generation sequencing (NGS) approaches have revealed unprecedented structural complexity with a pivotal role in regulating RNA function and stability. Here, we present new discoveries from the transcriptome-wide determination of RNA structuromes in bacteria and discuss emerging concepts in the role of mRNA structures in regulating transcription, translation and degradation. We also provide critical viewpoints on the use of NGS approaches for elucidating of RNA structuromes at the systems level.
Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. Electronic address: zoya.ignatova@uni-hamburg.de.
Zoya
Z
Ignatova
Department of Microbial Biology, Ruhr University Bochum, Bochum, Germany. Electronic address: franz.narberhaus@ruhr-uni-bochum.de.
Franz
F
Narberhaus
D001419:Bacteria / Q000235:genetics; D019295:Computational Biology; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D059014:High-Throughput Nucleotide Sequencing; D009690:Nucleic Acid Conformation; D012329:RNA, Bacterial / Q000737:chemistry* / Q000378:metabolism*; D012333:RNA, Messenger / Q000737:chemistry* / Q000378:metabolism; D017423:Sequence Analysis, RNA; D059467:Transcriptome
D012329:RNA, Bacterial; D012333:RNA, Messenger