A Structural View of αB-crystallin Assembly and Amyloid Aggregation.
The major len protein αB-crystallin (αB) is an intracellular chaperone. It belongs to the family of small heat shock proteins (sHsps) which plays a critical role in maintaining protein homeostasis and preventing protein aggregation, especially under stress conditions. Dysfunction of αB is closely related to cataract, and many neurodegenerative diseases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease. Due to the extremely heterogeneous and polydispersed nature of αB, it remains unclear how αB self-assemblies and prevents its client proteins from aggregation. In this minireview, we summarize the structural studies of αB in self-assembly, chaperoning client proteins and amyloid aggregation. We also mention the recent progress in identification of small molecules preventing αB aggregation for potential cataract treatment. This review highlights the polymorphic structures of αB under different conditions and its wide-spectrum chaperone activities, and sheds light on understanding the complex relationship among αB, client proteins and the related diseases.
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academic of Science, Shanghai. China.
Zhenying
Z
Liu
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academic of Science, Shanghai. China.
Shengnan
S
Zhang
Dan
D
Li
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese, Academic of Science, Shanghai. China.
Cong
C
Liu
D000682:Amyloid / Q000737:chemistry / Q000378:metabolism; D058227:Amyloidogenic Proteins / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002386:Cataract / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D019636:Neurodegenerative Diseases / Q000378:metabolism; D038203:alpha-Crystallin B Chain / Q000737:chemistry / Q000378:metabolism
D000682:Amyloid; D058227:Amyloidogenic Proteins; D038203:alpha-Crystallin B Chain
amyloid aggregation; atomic structure; cataract; neurodegenerative
diseases; small heat shock proteins; αB-crystallin