Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy.
Intraperitoneal internal radiation therapy is a cancer treatment option that is employed in situations where surgical resection, systemic chemotherapy, and external beam radiotherapy are not amenable for patients. However, exposure of noncancerous tissues to radiation continues to be a hindrance to safe and effective treatment of patients. In addition, reducing prolonged radiation exposure of personnel during preparation of internal radiation therapy agents makes their manufacture complicated and hazardous. Developments in nanotechnology have provided a platform for targeted treatments that combine dual imaging and treatment capabilities all in one package, while also being robust enough to withstand the intense stresses faced during neutron activation. Here, we describe a method for synthesizing neutron activatable mesoporous silica nanoparticles for use in radiotherapy of metastatic peritoneal cancers while limiting personal exposure to radioactive materials, limiting the leakage of radioactive isotopes caused by nanoparticle degradation during neutron activation, and increasing cancer tissue specificity of radiation.
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.
Derek
D
Hargrove
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA. xiuling.lu@uconn.edu.
Xiuling
X
Lu
D006695:Holmium / Q000737:chemistry; D006885:Hydroxybutyrates / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000532:radiotherapy*; D009502:Neutrons / Q000627:therapeutic use; D010422:Pentanones / Q000737:chemistry; D016062:Porosity; D011868:Radioisotopes / Q000008:administration & dosage; D012822:Silicon Dioxide / Q000737:chemistry
D006885:Hydroxybutyrates; D010422:Pentanones; D011868:Radioisotopes; C049529:acetyl acetonate; D012822:Silicon Dioxide; D006695:Holmium
Cancer; Intraperitoneal delivery; Nanotechnology; Neutron activation; Radiation therapy