Macrophage heterogeneity and renin-angiotensin system disorders.
Macrophages are heterogeneous innate immune cells which are important in both the maintenance of tissue homeostasis and its disruption, by promoting tissue inflammation and fibrosis. The renin-angiotensin system is central to the pathophysiology of a large suite of diseases, which are driven in part by large amounts of tissue inflammation and fibrosis. Here, we review recent advances in understanding macrophage heterogeneity in origin and function, and how these may lead to new insights into the pathogenesis of these chronic diseases.
Department of Immunology, Monash University, Prahran, Victoria, Australia.
Mark D
MD
Wright
Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia. katrina.binger@unimelb.edu.au.
Katrina J
KJ
Binger
D000818:Animals; D005355:Fibrosis / Q000473:pathology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008264:Macrophages / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology*
Fibrosis; Hypertension; Inflammation; Monocyte; Tissue resident macrophage