Neural mechanisms of mood-induced modulation of reality monitoring in schizophrenia.
Reality monitoring is the ability to accurately distinguish the source of self-generated information from externally-presented information. Although people with schizophrenia (SZ) show impaired reality monitoring, nothing is known about how mood state influences this higher-order cognitive process. Accordingly, we induced positive, neutral and negative mood states to test how different mood states modulate subsequent reality monitoring performance. Our findings indicate that mood affected reality monitoring performance in HC and SZ participants in both similar and dissociable ways. Only a positive mood facilitated task performance in Healthy Control (HC) subjects, whereas a negative mood facilitated task performance in SZ subjects. Yet, when both HC and SZ participants were in a positive mood, they recruited medial prefrontal cortex (mPFC) to bias better subsequent self-generated item identification, despite the fact that mPFC signal was reduced in SZ participants. Additionally, in SZ subjects, negative mood states also modulated left and right dorsal mPFC signal to bias better externally-presented item identification. Together our findings reveal that although the mPFC is hypoactive in SZ participants, mPFC signal plays a functional role in mood-cognition interactions during both positive and negative mood states to facilitate subsequent reality monitoring decision-making.
Department of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: karuna.subramaniam@ucsf.edu.
Karuna
K
Subramaniam
Department of Neurology, University of California, San Francisco, CA, USA.
Kamalini G
KG
Ranasinghe
Department of Psychiatry, University of California, San Francisco, CA, USA.
Daniel
D
Mathalon
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Srikantan
S
Nagarajan
Department of Psychiatry, University of California, San Francisco, CA, USA.
Sophia
S
Vinogradov
D000328:Adult; D000339:Affect / Q000502:physiology*; D000368:Aged; D001931:Brain Mapping / Q000379:methods; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology; D011936:Reality Testing; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology
Medial prefrontal cortex; Positive mood induction; Reality monitoring; Source memory; fMRI