Survival benefit of hepatic resection for hepatocellular carcinoma beyond the Barcelona Clinic Liver Cancer classification.
BACKGROUND
The Barcelona Clinic Liver Cancer (BCLC) classification is the most widely used staging system for hepatocellular carcinoma (HCC), but its prognostic ability in patients after resection has not been yet validated. The aim of this study was to evaluate the BCLC classification among patients after resection.


METHODS
The subjects were 196 patients who underwent hepatic resection for HCC between April 2003 and December 2014 at Jikei University Hospital. All patients were classified into a tumor stage according to the BCLC classification. Overall survival rate was calculated according to stages defined by the BCLC classification.


RESULTS
Overall survival rates at 1, 3 and 5-year were 100%, 95.2% and 95.2% in BCLC 0, 96.7%, 90.0% and 78.4% in BCLC A solitary, 86.2%, 86.2% and 86.2% in BCLC A multiple, 100.0%, 78.8% and 78.8% in BCLC B and 86.5%, 63.3% and 57.6% in BCLC C, respectively. Postoperative complications and mortality rates in relation to BCLC stage were comparable.


CONCLUSIONS
The BCLC treatment algorithm should consider the role of resection also for multiple early, intermediate and advanced stages.
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Kenei
K
Furukawa
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Hiroaki
H
Shiba
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Takashi
T
Horiuchi
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yoshihiro
Y
Shirai
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Koichiro
K
Haruki
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yuki
Y
Fujiwara
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Taro
T
Sakamoto
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Takeshi
T
Gocho
Department of Surgery, Jikei University School of Medicine 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Katsuhiko
K
Yanaga
D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D006528:Carcinoma, Hepatocellular / Q000145:classification* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods / Q000401:mortality*; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000145:classification* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D016019:Survival Analysis
Barcelona Clinic Liver Cancer classification; Hepatic resection; Hepatocellular carcinoma