Analyzing Amyloid Beta Aggregates with a Combinatorial Fluorescent Molecular Sensor.
Different amyloid beta (Aβ) aggregates can be discriminated by a combinatorial fluorescent molecular sensor. The unique optical fingerprints generated by the unimolecular analytical device provide a simple means to differentiate among aggregates generated from different alloforms or through distinct pathways. The sensor has also been used to track dynamic changes that occur in Aβ aggregation states, which result from the formation of low molecular weight oligomers, high molecular weight oligomers, protofibrils, and fibrils.
Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 7610001, Israel.
Joydev
J
Hatai
Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 7610001, Israel.
Leila
L
Motiei
Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 7610001, Israel.
David
0000-0002-8151-733X
D
Margulies
D016229:Amyloid beta-Peptides / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D066329:Protein Aggregates; D013816:Thermodynamics
D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D066329:Protein Aggregates