Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals.
Next-generation sequencing has expanded our understanding of the viral populations that constitute the mammalian virome. We describe a novel taxon of viruses named Statoviruses, for Stool associated Tombus-like viruses, present in multiple metagenomic datasets. These viruses define a novel clade that is phylogenetically related to the RNA virus families Tombusviridae and Flaviviridae. Five distinct statovirus types were identified in human, macaque, mouse, and cow gastrointestinal tract samples. The prototype genome, statovirus A, was frequently identified in macaque stool samples from multiple geographically distinct cohorts. Another genome, statovirus C1, was discovered in a stool sample from a human child with fever, cough, and rash. Further experimental data will clarify whether these viruses are infectious to mammals or if they originate from another source present in the mammalian gastrointestinal tract.
Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.
Andrew B
AB
Janowski
Department of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Siddharth R
SR
Krishnamurthy
Department of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Efrem S
ES
Lim
Department of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Guoyan
G
Zhao
Lab of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jason M
JM
Brenchley
Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center, Boston, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA.
Dan H
DH
Barouch
Department of Community Health, College of Medicine, University of Malawi, Blantyre 3, Malawi.
Chrissie
C
Thakwalakwa
Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.
Mark J
MJ
Manary
Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.
Lori R
LR
Holtz
Department of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: davewang@wustl.edu.
David
D
Wang
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D019295:Computational Biology; D005243:Feces / Q000821:virology; D041981:Gastrointestinal Tract / Q000821:virology*; D016679:Genome, Viral / Q000235:genetics*; D005843:Geography; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008253:Macaca mulatta; D008254:Macaca nemestrina; D051379:Mice; D010802:Phylogeny; D012327:RNA Virus Infections / Q000662:veterinary* / Q000821:virology; D012328:RNA Viruses / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA
D012367:RNA, Viral
Flaviviridae; Statoviruses; Tombusviridae; Viral discovery; Virome