Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior.
Whether invasive tumor phenotypes like EMT arise from oncogenic drivers or from priming of the pre-tumor cell of origin remains unknown. In this issue of Cell Stem Cell, Latil et al. (2017) show that the pre-tumor niche establishes a chromatin state predisposing squamous cell carcinomas to undergo EMT and metastasis, suggesting that the pre-tumor epigenome has prognostic value.
Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ramon J
RJ
Whitson
Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: oro@stanford.edu.
Anthony E
AE
Oro
D002294:Carcinoma, Squamous Cell; D057890:Epigenomics; D006801:Humans; D011379:Prognosis; D012987:Soil; D013234:Stem Cells
D012987:Soil