Designing and fabrication of curcumin loaded PCL/PVA multi-layer nanofibrous electrospun structures as active wound dressing.
Active wound dressings play a significant role in burn and chronic wound treatment. In this study, electrospinning process is used to fabricate a novel three-layer active wound dressing based on ε-polycaprolactone (PCL), polyvinylalcohol (PVA), and curcumin (CU) as a biologically active compound. The main purpose for developing such a system is to control wound exudates, which remains a challenge, as well as enjoying the anti-bacterial property. Electrospinning process parameters are optimized by response surface methodology to achieve appropriate nanofibrous electrospun mats, and then, a three-layer dressing has been designed in view of water absorbability, anti-bacterial, and biocompatibility characteristics of the final dressing. The results illustrate that a three-layer dressing based on PCL/curcumin containing PVA as a middle layer with optimized thickness which is placed over the incision, absorbs three times exudates in comparison with pristine dressing. Anti-bacterial tests reveal that the dressing containing 16% curcumin exhibits anti-bacterial activity without sacrificing the acceptable level of cell viability.
Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, Iran.
Seyed Mahdi
SM
Saeed
Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran.
Hamid
H
Mirzadeh
Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, Iran. m.zandi@ippi.ac.ir.
Mojgan
M
Zandi
Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, Iran.
Jalal
J
Barzin
Electrospinning; Nanofibers; Response surface; Wound dressing