Invited review: Anti-adhesive properties of bovine oligosaccharides and bovine milk fat globule membrane-associated glycoconjugates against bacterial food enteropathogens.
The prevalence of the main raw milk and raw milk-derived dairy product enteropathogens (Campylobacter, Shiga toxin-producing Escherichia coli, Listeria, and Salmonella) is higher than the number of epidemiological cases related to ingesting these foodstuffs. Bovine milk oligosaccharides and milk fat globule membrane (MFGM)-linked glycoconjugates interact with foodborne enteropathogens to inhibit their adhesion to intestinal cells and tissues. This review examines the main mechanisms and strategies used by enteropathogens to adhere to their target, details the anti-adhesive properties of MFGM against enteropathogens and enterotoxins, assesses the integrity of bacteria-MFGM complexes during dairy product manufacture and digestion, and discusses the potential for using these macromolecules and glycoconjugates in foods for public health.
Institut National de Recherche Agronomique, UR 545 Unité de Recherches Fromagères, 15000 Aurillac, France; Université de Lyon, Bacterial Opportunistic Pathogens and Environment Research Group, UMR5557 Ecologie Microbienne Lyon, Université Lyon 1, CNRS (National Center of Scientific Research), VetAgro Sup, 69280 Marcy-l'Etoile, France.
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Douëllou
Institut National de Recherche Agronomique, UR 545 Unité de Recherches Fromagères, 15000 Aurillac, France.
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Montel
Université de Lyon, Bacterial Opportunistic Pathogens and Environment Research Group, UMR5557 Ecologie Microbienne Lyon, Université Lyon 1, CNRS (National Center of Scientific Research), VetAgro Sup, 69280 Marcy-l'Etoile, France; Université de Lyon, VetAgro Sup-Campus Vétérinaire, Laboratoire d'Etudes des Microorganismes Alimentaires Pathogènes-French National Reference Laboratory for Escherichia coli including Shiga toxin-producing E. coli (NRL-STEC), 69280, Marcy-l'Etoile, France. Electronic address: delphine.sergentet@vetagro-sup.fr.
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Thevenot Sergentet
D000818:Animals; D002417:Cattle; D005516:Food Microbiology; D006001:Glycoconjugates; D006017:Glycolipids / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology*; D008566:Membranes; D008892:Milk / Q000382:microbiology; D009844:Oligosaccharides
D006001:Glycoconjugates; D006017:Glycolipids; D006023:Glycoproteins; D009844:Oligosaccharides
adhesion inhibition; bacterial enteropathogen; glycoconjugate; milk fat globule; oligosaccharides