Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease.
Possible association between Helicobacter pylori infection (HPI) and nonalcoholic fatty liver disease (NAFLD) has been proposed by several studies with inconsistent conclusions. Here, we studied the association between HPI and NAFLD at 3 levels: (i) genetic level; (ii) small molecular level; and (iii) clinical level. Relation data between diseases, genes, and small molecules were acquired from Pathway Studio ResNet Mammalian database. Clinical data were acquired from 2263 elderly South Chinese subjects, including 603 NAFLD patients and 1660 subjects without NAFLD. Results showed that HPI and NAFLD present significantly shared genetic bases (95 genes, p value = 2.5E-72), demonstrating multiple common genetic pathways (enrichment p value ≤ 4.38E-20 for the top 10 pathways). Genetic network analysis suggested that mutual regulation may exist between HPI and NAFLD through 21 out of 95 genes. Furthermore, 85 out of the 95 genes manifested strong interaction with 12 small molecules/drugs that demonstrate effectiveness in treating both diseases. Clinical results showed that HPI rate in the NAFLD group was significantly higher than that in the group without NAFLD (51.9% vs. 43.6%; p value = 4.9E-4). Multivariate logistic regression results supported the observations and suggested that HPI served as a risk factor for NAFLD in the experiment data studied (odds ratio: 1.387, p value = 0.018). Results from this study support the hypothesis that complex biological association may exist between HPI and NAFLD, which partially explains the significant clinical co-incidence in the elderly population of south China.
a Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China.|b Department of Gastroenterology, Zhenhai Lianhua Hospital, Ningbo, 315207, China.
Chang-Xi
CX
Chen
c Department of Endocrinology, the Affiliated Hospital of Medical College of Ningbo University, Ningbo, 315020, China.
Yu-Shan
YS
Mao
d Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD 20852, USA.
Parker
P
Foster
b Department of Gastroenterology, Zhenhai Lianhua Hospital, Ningbo, 315207, China.
Zhong-Wei
ZW
Zhu
b Department of Gastroenterology, Zhenhai Lianhua Hospital, Ningbo, 315207, China.
Juan
J
Du
e Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Chuan-Yong
CY
Guo
D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D005260:Female; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D059647:Gene-Environment Interaction; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D012307:Risk Factors
Helicobacter pylori infection; ResNet Database; analyse de connectivité du réseau; analyse d’enrichissement de voies; base de données ResNet; infection par Helicobacter pylori; network connectivity analysis; nonalcoholic fatty liver disease; pathway enrichment analysis; stéatose hépatique non alcoolique