Multidrug-resistant tuberculosis in transplant recipients: Case report and review of the literature.
Transplant recipients are at increased risk of tuberculosis (TB). We describe a case of pulmonary and vertebral multidrug-resistant TB (MDR-TB) in a kidney transplant patient who required neurosurgical intervention and unfortunately developed fatal nosocomial complications. Thirteen transplant recipients with MDR-TB were previously reported in the literature (one hematopoietic cell transplant, one heart transplant, one lung transplant, one heart-lung transplant, and nine kidney transplant recipients). Extrapulmonary disease, severe treatment complications, and deaths were observed in patients who developed MDR-TB after transplantation.
Division of Infectious Diseases, University of Kentucky College of Medicine, Lexington, KY, USA.
Moises A
MA
Huaman
Kentucky Department for Public Health, Frankfort, KY, USA.
Robert
R
Brawley
Southeastern National Tuberculosis Center, Gainesville, FL, USA.
David
D
Ashkin
D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003428:Cross Infection / Q000150:complications / Q000382:microbiology; D003928:Diabetic Nephropathies / Q000150:complications; D024901:Drug Resistance, Multiple, Bacterial; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification / Q000502:physiology*; D019635:Neurosurgical Procedures; D018410:Pneumonia, Bacterial / Q000382:microbiology; D016133:Polymerase Chain Reaction; D012131:Respiratory Insufficiency / Q000209:etiology; D012772:Shock, Septic / Q000382:microbiology; D066027:Transplant Recipients; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy*; D014399:Tuberculosis, Spinal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
D000995:Antitubercular Agents
multidrug resistance; transplantation; tuberculosis