Light-Triggered Inactivation of Enzymes with Photothermal Nanoheaters.
A universal method for inactivating enzymes on demand is introduced, which involves irradiating nanorod-bound enzymes with near-infrared light. The subsequent generation of plasmonic heat denatures the enzymes selectively without damaging other proteins or cell membranes present in the same solution.
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, Scotland, UK.|Department of Chemistry and Biochemistry, Hunter College-City University of New York, New York, NY, 10065, USA.
Sebastian A
SA
Thompson
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, Scotland, UK.
Sureyya
S
Paterson
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, Scotland, UK.
Marwa M M
MM
Azab
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, Scotland, UK.
Alastair W
AW
Wark
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, Scotland, UK.
Roberto
R
de la Rica
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004789:Enzyme Activation / Q000528:radiation effects; D005949:Glucose Oxidase / Q000378:metabolism*; D006735:Horseradish Peroxidase / Q000378:metabolism*; D008027:Light; D043942:Nanotubes / Q000737:chemistry*; D013696:Temperature
D005949:Glucose Oxidase; D006735:Horseradish Peroxidase
glucose oxidase; gold; horseradish peroxidase; hyperthermia; nanorods