Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016.
In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Of the 16 total L2c LGV cases, 10 had severe haemorrhagic proctitis. These findings are concerning as cases with this new genovariant among MSM have not been frequently reported in Europe to date. More research is needed to assess the spread of the L2c genovariant and its potential association with virulence and severe clinical manifestation.
Department of Bacteriology II., National Centre for Epidemiology, Budapest, Hungary.
Fruzsina
F
Petrovay
Department of Bacteriology II., National Centre for Epidemiology, Budapest, Hungary.
Eszter
E
Balla
Department of Phage and Molecular Typing, National Centre for Epidemiology, Budapest, Hungary.
Tímea
T
Erdősi
D000293:Adolescent; D000328:Adult; D002692:Chlamydia trachomatis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D018451:Homosexuality, Male; D006801:Humans; D006814:Hungary; D008219:Lymphogranuloma Venereum / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011349:Proctitis / Q000175:diagnosis / Q000382:microbiology*; D012002:Rectal Diseases / Q000175:diagnosis / Q000382:microbiology; D012007:Rectum / Q000382:microbiology*; D017421:Sequence Analysis
Chlamydia trachomatis; L2c genovariant; lymphogranuloma venereum (LGV); men who have sex with men (MSM)