Modulation of host immune responses to Toxoplasma gondii by microRNAs.
To survive successfully, Toxoplasma counteracts the strictly regulated host innate response to downregulate inflammation that could be deleterious for the parasite. MicroRNAs are vital regulators of both innate and adaptive immunity, controlling the maintenance and development of immune progenitors as well as the differentiation and the functions of host mature immune cells. Thus, the complexity of mechanisms underlying the connection between Toxoplasma and host immunity has led to investigations of miRNAs as additional key molecular players. The knowledge acquired from these studies will be useful for aiding the discovery of new targets for diagnosis or therapeutic approaches for toxoplasmosis and insight into the interaction between host and parasite.
Department of Laboratory Medicine, School of Public Health, Anhui Medical University, Hefei, China.
Y
Y
Cai
Department of Parasitology, Provincial Laboratory of Pathogen Biology Anhui and the Key Laboratory of Zoonoses Anhui, Anhui Medical University, Hefei, China.
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0000-0002-4755-3687
J
Shen
D056704:Adaptive Immunity / Q000235:genetics* / Q000276:immunology; D000818:Animals; D015536:Down-Regulation / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D035683:MicroRNAs / Q000235:genetics*; D014122:Toxoplasma / Q000276:immunology* / Q000472:pathogenicity; D014123:Toxoplasmosis / Q000276:immunology* / Q000469:parasitology
D035683:MicroRNAs
 Toxoplasma gondii ; disease; gene expression; immune modulation; immunological terms; parasite; tools and techniques; toxoplasmosis