Search of the p.M918T Mutation in the RET Oncogene in Mexican Adult Patients with Medullary Thyroid Carcinoma.
Inherited mutations in the RET proto-oncogene, which encodes a receptor tyrosine kinase, predispose individuals to the multiple endocrine neoplasia type 2 (MEN 2) cancer syndromes. The major component tumor of these syndromes is medullary thyroid carcinoma (MTC). To date, somatic mutations in RET have been identified in tumors from individuals with MEN 2 finding. RET M918T mutation is present in 95% of the MEN2B cases, and approximately 50% of sporadic MTCs harbor this mutation. We performed a mutational analysis in 17 cases of Medullary thyroid carcinoma, the somatic missense mutation at codon 918 of RET was found in 2 of the 17 MTCs, and one case presented MEN2 phenotype including MTC. The percentage of RET M918T mutation is similar in Mexican MTC patients to other series, although other mutations could be implicated in our population.
Translational Medicine Laboratory, National Cancer Institute, Mexico City, Mexico City.
Erika
E
Ruiz-Garcia
Molecular Diagnostic Laboratory, National Cancer Institute, Mexico City.
Silvia
S
Vidal-Millan
Translational Medicine Laboratory, National Cancer Institute, Mexico City, Mexico City.
Alicia
A
Lopez-Yañez
Head and Neck Cancer Deparment, National Cancer Institute, Mexico City.
José Antonio Posada
JAP
Torres
Translational Medicine Laboratory, National Cancer Institute, Mexico City, Mexico City.
Jorge Alberto
JA
Guadarrama-Orozco
Onco-Pathology Department, National Cancer Institute, Mexico City.
Leonardo Saul
LS
Lino-Silva
Translational Medicine Laboratory, National Cancer Institute, Mexico City, Mexico City.
Abelardo
A
Meneses-Garcia
Traslational Cancer Research Unit, Centro Medico Nacional Siglo XXI IMSS.
Horacio
H
Astudillo-de la Vega
Head and Neck Cancer Deparment, National Cancer Institute, Mexico City.
Martin Granados
MG
Garcia
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D018278:Carcinoma, Neuroendocrine / Q000453:epidemiology / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D020125:Mutation, Missense; D000090063:Proto-Oncogene Mas; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D013912:Threonine / Q000235:genetics; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D013912:Threonine; D008715:Methionine; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human