Lack of association between MAOA-uVNTR variants and excessive daytime sleepiness.
Sleep disorders are highly prevalent in the population and have dramatic health, social, and economic impacts. However, their treatments may remain symptomatic due to ignorance of molecular factors which may provide fundamental insights into the neurological bases of sleep. Excessive daytime sleepiness (EDS) is a common complaint encountered in neurological practice with significant effects both on individuals and on society. We aimed to investigate the role of monoamine oxidase A (MAOA) as a candidate gene in EDS. Epworth sleepiness scale (ESS) was applied to 221 subjects who were also genotyped for MAOA upstream variable number of tandem repeats (MAOA-uVNTR). Patient group displayed higher ESS values (mean 12.67) when compared with the control group (mean 6.38). However, MAOA-uVNTR genotypes did not show a significant association with ESS scores neither on women nor on men. Finally, these data suggest further replications in different populations. Moreover, the investigation of some other genes together with MAOA and/or some possible regulatory molecular mechanisms may offer a more comprehensive approach in the role of genetic factors contributing to EDS.
Department of Medical Genetics, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Filiz
F
Ozen
Medical Laboratory Techniques Program, Vocational School of Health Services, Sinop University, Sinop, Turkey. zyegin@sinop.edu.tr.
Zeynep
Z
Yegin
Department of Neurology, Faculty of Medicine, Bahcesehir University, Istanbul, Turkey.
Figen
F
Yavlal
Department of Family Medicine, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Zuhal Aydan
ZA
Saglam
Department of Statistics, Faculty of Science, Cankiri Karatekin University, Cankiri, Turkey.
Haydar
H
Koc
Department of Biology, Faculty of Science and Arts, Sinop University, Sinop, Turkey.
Ismet
I
Berber
D000328:Adult; D006970:Disorders of Excessive Somnolence / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D008995:Monoamine Oxidase / Q000235:genetics*; D011569:Psychiatric Status Rating Scales
D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
Excessive daytime sleepiness; MAOA-uVNTR; Monoamine oxidase A; Neurogenetics; Sleep; Variable number tandem repeat