Ga@C-dots as an antibacterial agent for the eradication ofPseudomonas aeruginosa.
The opportunistic pathogenPseudomonas aeruginosacauses infections that are difficult to treat by antibiotic therapy. This research article reports on the synthesis of gallium (Ga) doped in carbon (C)-dots (Ga@C-dots) and their antimicrobial activity against free-livingP. aeruginosabacteria. The synthesis of Ga@C-dots was carried out by sonicating molten Ga (for 2.5 h) in polyethylene glycol-400, which acts as both a medium and carbon source. The resultant Ga@C-dots, having an average diameter of 9±2 nm, showed remarkably enhanced antibacterial activity compared with undoped C-dots. This was reflected by the much lower concentration of Ga doped within Ga@C-dots which was required for full inhibition of the bacterial growth. These results highlight the possibility of using Ga@C-dots as potential antimicrobial agents.
Department of Chemistry.
Vijay Bhooshan
VB
Kumar
Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan Institute for Nanotechnology and Advanced Materials Bar-Ilan University, Ramat Gan.
Michal
M
Natan
Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan Institute for Nanotechnology and Advanced Materials Bar-Ilan University, Ramat Gan.
Gila
G
Jacobi
Division of Chemistry, Nuclear Research Center-Negev; Institutes of Applied Research, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Ze'ev
Z
Porat
Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan Institute for Nanotechnology and Advanced Materials Bar-Ilan University, Ramat Gan.
Ehud
E
Banin
Department of Chemistry; National Cheng Kung University, Department of Materials Science and Engineering, Tainan, Taiwan.
Aharon
A
Gedanken
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002244:Carbon / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D005708:Gallium / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013059:Spectrum Analysis, Raman; D055672:Static Electricity
D000900:Anti-Bacterial Agents; D002244:Carbon; D005708:Gallium
C-dots; Ga@C-dots; Pseudomonas aeruginosa; antibacterial; gallium; sonochemistry