Diagnostic value of renal perfusion in patients with chronic kidney disease using 3D arterial spin labeling.
To evaluate the diagnostic value of 3D arterial spin labeling (ASL) for noninvasive quantification of renal blood flow (RBF) in patients with chronic kidney disease (CKD).



CKD patients (n = 27) and healthy volunteers (n = 36) underwent renal 3T ASL magnetic resonance imaging, with inversion times from 1200 to 2000 msec for volunteers in the preliminary test, and 1800 to 2000 msec for volunteers and CKD patients in the formal experiments. The cortical RBFs were compared, and a correlation between RBF and estimated glomerular filtration rate (eGFR) was evaluated.



For healthy volunteers, RBF values increased with TIs from 1200 to 1600 msec, but were almost constant at TIs from 1600 to 2000 msec. The cortical RBF values of CKD patients were lower than that of healthy volunteers at TIs from 1800 to 2000 msec. In addition, the CKD patients had lower cortical RBF values than the healthy volunteers (P < 0.01 for both), and their RBF values positively correlated with eGFR.



3D ASL is a potential noninvasive method for measuring renal perfusion that can provide valuable information for clinical CKD diagnosis.



1 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2017;46:589-594.
Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China.
Yu-Zhe
YZ
Cai
Department of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China.
Zhi-Cheng
ZC
Li
Siemens Healthcare, MR Collaboration NE Asia, Beijing, PR China.
Pan-Li
PL
Zuo
Application Development, Siemens Healthcare, Erlangen, Germany.
Josef
J
Pfeuffer
Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China.
Yu-Ming
YM
Li
Department of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China.
Fang
F
Liu
Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China.
Rong-Bo
RB
Liu
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D005260:Female; D005919:Glomerular Filtration Rate; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D012077:Renal Artery / Q000000981:diagnostic imaging; D012079:Renal Circulation; D015203:Reproducibility of Results; D013113:Spin Labels; D055815:Young Adult
D013113:Spin Labels
arterial spin labeling (ASL); chronic kidney disease (CKD); magnetic resonance imaging (MRI); renal blood flow (RBF)