Placental and lactational transfer of decabromodiphenyl ether and 2,2',4,4'-tetrabromodiphenyl ether in dam-offspring pairs of Sprague-Dawley rats.
Although several studies have conducted maternal transfer of individual PBDE congener in experimental animals, there is a paucity of research on differences in maternal transfer of PBDE congeners. The purpose of the study was to investigate and compare placental and lactational transfer of BDE 47, -209 and its metabolites in rat dam-offspring pairs following repeated administration of BDE 47 and -209.13C-BDE 47, BDE 209 and its debrominated congeners were detected both in dam serum and offspring body, which indicates that PBDEs can be maternally transferred. In addition, BDE 196 and -197 appeared in offspring body earlier than in maternal serum, which suggests that debromination can be occur in offspring body. BDE 209 increased in both dam and offspring while levels of13C-BDE 47 was not increased in dam serum. 13C-BDE 47 seems to be stored in breast milk rather than in maternal serum, which can be assumed through the drastic increase of the congener in suckling pups. The magnitude of lactational transfer of the administered congeners was greater than that of placental transfer. And13C-BDE 47 was relatively more transferred to suckling pups than BDE 209 through breastfeeding.
Graduate School of Public Health, Seoul National University, Seoul 151-742, South Korea.
Mi-Yeon
MY
Shin
Department of Marine Science and Convergent Technology, Hanyang University, Ansan 426-791, South Korea.
Sunggyu
S
Lee
Graduate School of Public Health, Seoul National University, Seoul 151-742, South Korea.
Hyeyoung
H
Choi
Graduate School of Public Health, Seoul National University, Seoul 151-742, South Korea.
Da-In
DI
Jeong
Department of Marine Science and Convergent Technology, Hanyang University, Ansan 426-791, South Korea.
Hyo-Bang
HB
Moon
Graduate School of Public Health, Seoul National University, Seoul 151-742, South Korea; Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 151-742, South Korea. Electronic address: ddram2@snu.ac.kr.
Sungkyoon
S
Kim
D000818:Animals; D004785:Environmental Pollutants / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000493:pharmacokinetics* / Q000633:toxicity; D007774:Lactation; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D008892:Milk / Q000737:chemistry; D010920:Placenta / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D017207:Rats, Sprague-Dawley
D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; C511295:2,2',4,4'-tetrabromodiphenyl ether; C010902:decabromobiphenyl ether
2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether (BDE 209); 2,2′,4,4′-tetrabromodiphenyl ether (BDE 47); Lactational transfer; Placental transfer; Sprague-Dawley rat