Antifungal activity of wide band gap Thioglycolic acid capped ZnS:Mn semiconductor nanoparticles against some pathogenic fungi.
The manganese doped zinc sulfide nanoparticles were synthesized by simple aqueous chemical reaction of manganese chloride, zinc acetate and thioacitamide in aqueous solution. Thioglycolic acid is used as capping agent for controlling the nanoparticle size. The main advantage of the ZnS:Mn nanoparticles of diameter ~2.73nm is that the sample is prepared by using non-toxic precursors in a cost effective and eco-friendly way. The structural, morphological and chemical composition of the nanoparticles have been investigated by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) with energy dispersion spectroscopy (EDS) and Fourier transform infrared (FTIR) spectroscopy. The nanosize of the prepared nanoparticles was elucidated by Scanning Electron Microscopy (SEM). FTIR result ensures that Thioglycolic acid is well bonded on the surface of ZnS:Mn NPs. The antifungal effects of Thioglycolic acid capped ZnS:Mn nanoparticles exhibited a potent antifungal activity against tested fungal strains, so deserving further investigation for clinical applications. The antifungal property of manganese doped zinc sulphide nanoparticles is attributed to the generation of reactive oxygen species due to the interaction of nanoparticles with water. Additionally, the presence of Zn and S in the zone of inhibition area leads to perturbation of fungi cell membranes resulting in growth inhibition.
Department of physics, College of Science, Baghdad University, Baghdad, Iraq.
Isam M
IM
Ibrahim
Department of physics, College of Science, Baghdad University, Baghdad, Iraq.
Iftikhar M
IM
Ali
Department of Biology, College of Education, Iraqia University, Baghdad, Iraq.
Batol Imran
BI
Dheeb
Department of physics, College of Education, University of Anbar, Anbar, Iraq.
Qayes A
QA
Abas
Department of physics, College of Science, University of Anbar, Anbar, Iraq; Renewable energy Research Center, University of Anbar, Anbar, Iraq. Electronic address: asmat_hadithi@yahoo.com.
Asmeit Ramizy
Department of physics, College of Science, Sudan University of Science Technology, Khartoum 11113, Sudan; Department of physics, College of Science, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
M H
MH
Eisa
Department of physics, College of Science, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
A I
AI
Aljameel
D000935:Antifungal Agents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D008345:Manganese / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012666:Semiconductors; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides / Q000737:chemistry*; D013864:Thioglycolates / Q000494:pharmacology*; D014961:X-Ray Diffraction; D017967:Zinc Compounds / Q000737:chemistry*
D000935:Antifungal Agents; D013440:Sulfides; D013864:Thioglycolates; D017967:Zinc Compounds; D008345:Manganese; C017487:2-mercaptoacetate; C031238:zinc sulfide
Anti-fungal; Aqueous chemical synthesis; Nanoparticles; ZnS:Mn