Hyperbranched Polyglycerol-Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo.
Mesoporous silica-based nanoparticles are generally accepted as a potential platform for drug loading with a lot of advantages, except for their complex purification procedures and structures that are difficult to decompose. In this work, biocompatible hyperbranched polyglycerol is introduced to synthesize mesoporous silica nanoparticles (MSNs). The materials possess good biocompatibility, controlled release, and biodegradability. They also show passive targeting capability through the enhanced permeability and retention effect and can be excreted from the biological system. The method avoids the needs to employ traditional surfactants and complicated purified procedures, which make these MSNs an efficient delivery system for cancer therapy.
National Center for Nanoscience and Technology Zhong Guan Cun, Bei Yi Tiao 11 Beijing 100190 P. R. China.
Yang
Y
Yang
National Center for Nanoscience and Technology Zhong Guan Cun, Bei Yi Tiao 11 Beijing 100190 P. R. China.
Anhe
A
Wang
Department of Chemistry and Biochemistry Freie Universität Berlin Takustrasse 3 14195 Berlin Germany.
Qiang
Q
Wei
Department of Chemistry and Biochemistry Freie Universität Berlin Takustrasse 3 14195 Berlin Germany.
Cathleen
C
Schlesener
Department of Chemistry and Biochemistry Freie Universität Berlin Takustrasse 3 14195 Berlin Germany.
Rainer
R
Haag
Key Lab of Colloid, Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Zhong Guan Cun, Bei Yi Jie 2 Beijing 100190 P. R. China.
Qi
Q
Li
National Center for Nanoscience and Technology Zhong Guan Cun, Bei Yi Tiao 11 Beijing 100190 P. R. China; Key Lab of Colloid, Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Zhong Guan Cun, Bei Yi Jie 2 Beijing 100190 P. R. China.
Junbai
J
Li
biodegradation; cancer therapy; drug delivery; hyperbranched polyglycerol; silica nanoparticles