Value of quantitative MRI parameters in predicting and evaluating clinical outcome in conservatively treated patients with chronic midportion Achilles tendinopathy: A prospective study.
OBJECTIVE
To evaluate whether baseline MRI parameters provide prognostic value for clinical outcome, and to study correlation between MRI parameters and clinical outcome.


METHODS
Observational prospective cohort study.


METHODS
Patients with chronic midportion Achilles tendinopathy were included and performed a 16-week eccentric calf-muscle exercise program. Outcome measurements were the validated Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire and MRI parameters at baseline and after 24 weeks. The following MRI parameters were assessed: tendon volume (Volume), tendon maximum cross-sectional area (CSA), tendon maximum anterior-posterior diameter (AP), and signal intensity (SI). Intra-class correlation coefficients (ICCs) and minimum detectable changes (MDCs) for each parameter were established in a reliability analysis.


RESULTS
Twenty-five patients were included and complete follow-up was achieved in 20 patients. The average VISA-A scores increased significantly with 12.3 points (27.6%). The reliability was fair-good for all MRI-parameters with ICCs>0.50. Average tendon volume and CSA decreased significantly with 0.28cm3(5.2%) and 4.52mm2(4.6%) respectively. Other MRI parameters did not change significantly. None of the baseline MRI parameters were univariately associated with VISA-A change after 24 weeks. MRI SI increase over 24 weeks was positively correlated with the VISA-A score improvement (B=0.7, R2=0.490, p=0.02).


CONCLUSIONS
Tendon volume and CSA decreased significantly after 24 weeks of conservative treatment. As these differences were within the MDC limits, they could be a result of a measurement error. Furthermore, MRI parameters at baseline did not predict the change in symptoms, and therefore have no added value in providing a prognosis in daily clinical practice.
Department of Orthopaedics, Erasmus Medical Centre, The Netherlands. Electronic address: jonathantsehaie@gmail.com.
J
J
Tsehaie
Department of Medical Informatics & Radiology, Erasmus Medical Centre, The Netherlands.
D H J
DHJ
Poot
Department of Radiology, Erasmus Medical Centre, The Netherlands.
E H G
EHG
Oei
Department of Orthopaedics, Erasmus Medical Centre, The Netherlands.
J A N
JAN
Verhaar
Department of Orthopaedics, Erasmus Medical Centre, The Netherlands.
R J
RJ
de Vos
D000125:Achilles Tendon / Q000000981:diagnostic imaging* / Q000503:physiopathology; D000328:Adult; D000072700:Conservative Treatment; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D052256:Tendinopathy / Q000000981:diagnostic imaging* / Q000628:therapy*
Achilles tendon; Eccentric calf muscle exercise; MRI; Prognosis; Tendinopathy; VISA-A