Effects of Age on Esophageal Motility: Use of High-resolution Esophageal Impedance Manometry.
OBJECTIVE
Disturbances of esophageal motility have been reported to be more frequent the aged population. However, the physiology of disturbances in esophageal motility during aging is unclear. The aim of this study was to evaluate the effects of age on esophageal motility using high-resolution esophageal impedance manometry (HRIM).


METHODS
Esophageal motor function of 268 subjects were measured using HRIM in 3 age groups, < 40 years (Group A, n = 32), 40-65 years (Group B, n = 185), and > 65 years (Group C, n = 62). Lower esophageal sphincter (LES) and upper esophageal sphincter (UES) pressures, integrated relaxation pressure, distal contractile integral, contractile front velocity, distal latency, and pressures and duration of contraction on 4 positions along the esophagus, and complete bolus transit were measured.


RESULTS
Basal UES pressure was lower in Group C (P< 0.001) but there was no significant difference in the LES pressure among groups. Contractile duration on position 3 (10 cm from proximal LES high pressure zone) was longer in Group C (P= 0.001), and the contractile amplitude on position 4 (5 cm from proximal LES high pressure zone) was lower in Group C (P= 0.005). Distal contractile integral was lower in Group C (P= 0.037). Contractile front velocity (P= 0.015) and the onset velocity (P= 0.040) was lower in Group C. There was no significant difference in impedance values.


CONCLUSIONS
The decrease of UES pressure, distal esophageal motility, and peristaltic velocity might be related with esophageal symptoms in the aged population.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Young Kwang
YK
Shim
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.|Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine and Liver Research Institute, Seoul, Korea.
Nayoung
N
Kim
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Yo Han
YH
Park
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Jong-Chan
JC
Lee
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Jihee
J
Sung
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Yoon Jin
YJ
Choi
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Hyuk
H
Yoon
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Cheol Min
CM
Shin
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Young Soo
YS
Park
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.|Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine and Liver Research Institute, Seoul, Korea.
Dong Ho
DH
Lee
Aging; Esophageal motility; Manometry