Current advances in biological production of propionic acid.
Propionic acid and its derivatives are considered "Generally Recognized As Safe" food additives and are generally used as an anti-microbial and anti-inflammatory agent, herbicide, and artificial flavor in diverse industrial applications. It is produced via biological pathways using Propionibacterium and some anaerobic bacteria. However, its commercial chemical synthesis from the petroleum-based feedstock is the conventional production process bit results in some environmental issues. Novel biological approaches using microorganisms and renewable biomass have attracted considerable recent attention due to economic advantages as well as great adaptation with the green technology. This review provides a comprehensive overview of important biotechnological aspects of propionic acid production using recent technologies such as employment of co-culture, genetic and metabolic engineering, immobilization technique and efficient bioreactor systems.
Department of Material and Bioprocess Engineering, Faculty of Chemical Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Ismail
I
Eş
Department of Food Science, Faculty of Food Engineering, University of Campinas (UNICAMP), Rua Monteiro Lobato, 80, Caixa Postal: 6121, CEP: 13083-862, Campinas, SP, Brazil. Mousavi@fea.unicamp.br.
Amin Mousavi
http://orcid.org/0000-0001-5769-0004
AM
Khaneghah
Department of Food Science and Technology, College of Agriculture, Fasa University, Fasa, Iran.
Seyed Mohammad Bagher
SMB
Hashemi
Sorbonne Universités, Université de Technologie de Compiègne, Laboratoire Transformations Intégrées de la Matière Renouvelable (UTC/ESCOMEA 4297 TIMR), Centre de Recherche de Royallieu, CS 60319, 60203, Compiègne Cedex, France.
Mohamed
M
Koubaa
D019149:Bioreactors / Q000382:microbiology*; D018914:Cells, Immobilized; D060847:Metabolic Engineering / Q000379:methods*; D011422:Propionates / Q000378:metabolism*; D011424:Propionibacterium / Q000378:metabolism*
D011422:Propionates
Bioreactor; Immobilization; Metabolic engineering; Microbial production; Propionic acid