Congenital Hypothyroidism: Facts, Facets & Therapy.
Thyroid hormone (T3) is essential for normal development of children enabling brain development and somatic growth. However, certain individuals are genetically predisposed with insufficient or no thyroid hormones. Such a condition is termed congenital hypothyroidism (CH).



In the present review, a brief back ground about congenital hypothyroidism, factors associated with CH leading to thyroid dysgenesis and thyroid dyshormonogenesis is elaborated. Additionally, the guidelines for available treatment options, management and follow-up required for patients diagnosed with CH are discussed. Treatment options in terms of treatment initiation and dosage of hormone replacement are discussed.



Though CH is considered as the most common neonatal metabolic disorder, it is also easily treatable compared to other metabolic or hereditary diseases. The outcome of CH treatment depends on the compliance of parents early in life and by patients themselves during later part of life.
Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh. India.
Yedukondalu
Y
Kollati
Food Science and Technology Programme, Beijing Normal University-Hong Kong Baptist University United International College, 28, Jinfeng Road, Tangjiawan, Zhuhai-519085, Guangdong. China.
Ranga Rao
RR
Ambati
Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh. India.
Prakash Narayana
PN
Reddy
Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh. India.
N Satya Sampath
NSS
Kumar
Sandor Animal Biogenics Private Limited, Sandor Life Sciences, Telangana-500043. India.
Rajesh K
RK
Patel
Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur-5222, Andhra Pradesh. India.
Vijaya R
VR
Dirisala
D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy*; D020249:Hormone Replacement Therapy; D006801:Humans; D013963:Thyroid Hormones / Q000627:therapeutic use*
D013963:Thyroid Hormones
Congenital hypothyroidism; Thyroid hormone (T3); hormone therapy; levothyroxine; thyroid gland; transcription factors