Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review.
Clear-cell cholangiocarcinoma is a very uncommon variant of cholangiocarcinoma with a largely unknown natural history and prognosis. We report a case of a 51-year-old previously healthy woman presenting with a large liver nodule found on routine imaging. Needle biopsy of the lesion suggested a non-hepatocellular carcinoma. After extensive workup for other primary neoplasms, the patient underwent a partial hepatectomy. Histopathology was compatible with a moderately differentiated clear-cell cholangiocarcinoma. There was no evidence of liver disease in the remaining tissue. The patient underwent chemotherapy and remains in clinical remission after two years.
Gastrenterologia e Hepatologia, Hospital Santa Maria, Portugal.
Samuel Raimundo
SR
Fernandes
Serviço de Gastrenterologia e Hepatologia, Hospital de Santa Maria, Centro Hospitalar Lisboa , Portugal.
Cilénia
C
Baldaia
Serviço de Cirurgia Hepatobiliar, Hospital Curry Cabral, Portugal.
Hugo
H
Pinto Marques
Hospital de Santa Maria, Centro Hospitalar Lisboa , Serviço de Anatomia Patológica, Portugal.
Francisco
F
Tortosa
Fernando.ramalho@chln.min-saude.pt, Fernando.ramalho@chln.min-saude.pt, Portugal.
Fernando
F
Ramalho
D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000473:pathology; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged