Deletion/insertion polymorphism in the angiotension - converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease.
The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger man 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3 - fold increase in the risk for CHD.
Division of Medical Genetics, Department of Obstetrics and Gynecology, UMC Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia, , , , , , SI.
Borut
B
Peterlin
Division of Medical Genetics, Department of Obstetrics and Gynecology, UMC Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia, , , , , , SI.
Daniel
D
Petrovič
Institute of Histology and Embryology, Medical Faculty Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia, , , , , , SI.
Metka
M
Zorc
Division of Vascular Diseases, Department of Internal Medicine, UMC Ljubljana, Riharjeva 24, 1000 Ljubljana, Slovenia, , , , , , SI.
Irena
I
Keber
Key words: angiotensin-converting enzyme; coronary heart disease; genetic polymorphism; risk factor