Somatic clonal evolution: A selection-centric perspective.
It is generally accepted that the initiation and progression of cancers is the result of somatic clonal evolution. Despite many peculiarities, evolution within populations of somatic cells should obey the same Darwinian principles as evolution within natural populations, i.e. variability of heritable phenotypes provides the substrate for context-specific selection forces leading to increased population frequencies of phenotypes, which are better adapted to their environment. Yet, within cancer biology, the more prevalent way to view evolution is as being entirely driven by the accumulation of "driver" mutations. Context-specific selection forces are either ignored, or viewed as constraints from which tumor cells liberate themselves during the course of malignant progression. In this review, we will argue that explicitly focusing on selection forces acting on the populations of neoplastic cells as the driving force of somatic clonal evolution might provide for a more accurate conceptual framework compared to the mutation-centric driver gene paradigm. Whereas little can be done to counteract the "bad luck" of stochastic occurrences of cancer-related mutations, changes in selective pressures and the phenotypic adaptations they induce can, in principle, be exploited to limit the incidence of cancers and to increase the efficiency of existing and future therapies. This article is part of a Special Issue entitled: Evolutionary principles - heterogeneity in cancer?, edited by Dr. Robert A. Gatenby.
Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.
Jacob
J
Scott
Department of Molecular Imaging and Metabolism, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: Andriy.Marusyk@moffitt.org.
Andriy
A
Marusyk
D000222:Adaptation, Physiological; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D060965:Clonal Evolution; D019143:Evolution, Molecular; D015972:Gene Expression Regulation, Neoplastic; D056084:Genetic Fitness; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010375:Pedigree; D010641:Phenotype; D015398:Signal Transduction / Q000235:genetics; D013997:Time Factors
D014408:Biomarkers, Tumor
Cancer; Driver; Initiation; Natural selection; Progression; Selective pressures