Basic evaluation of typical nanoporous silica nanoparticles in being drug carrier: Structure, wettability and hemolysis.
Herein, the present work devoted to study the basic capacity of nanoporous silica nanoparticles in being drug carrier that covered structure, wettability and hemolysis so as to provide crucial evaluation. Typical nanoporous silica nanoparticles that consist of nanoporous silica nanoparticles (NSN), amino modified nanoporous silica nanoparticles (amino-NSN), carboxyl modified nanoporous silica nanoparticles (carboxyl-NSN) and hierachical nanoporous silica nanoparticles (hierachical-NSN) were studied. The results showed that their wettability and hemolysis were closely related to structure and surface modification. Basically, wettability became stronger as the amount of OH on the surface of NSN was higher. Both large nanopores and surface modification can reduce the wettability of NSN. Furthermore, NSN series were safe to be used when they circulated into the blood in low concentration, while if high concentration can not be avoided during administration, high porosity or amino modification of NSN were safer to be considered. It is believed that the basic evaluation of NSN can make contribution in providing scientific instruction for designing drug loaded NSN systems.
Faculty of Wu Ya, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China. Electronic address: dddefghijklmn@163.com.
Jing
J
Li
School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China.
Yingyu
Y
Guo
D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D006461:Hemolysis; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry*; D017155:Wettability
D004337:Drug Carriers; D012822:Silicon Dioxide
Drug carrier; Nanoporous silica nanoparticles; Wettability, hemolysis