Sudden Cardiac Arrest Triggered by Coadministration of Fluconazole and Amiodarone.
Fluconazole for fungal infections and amiodarone for arrhythmia are commonly prescribed medications, and coadministration of such medications is sometimes inevitable in clinical practice. However, both medications have been associated with prolonged QTc intervals and subsequent arrhythmias, which are sometimes fatal. We present the case of a 75-year-old man with sudden cardiac arrest triggered by coadministration of fluconazole and amiodarone, which raises the need for caution regarding coadministration of these medications. To our knowledge, this case has not been previously described.
Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jiajia
J
Wang
Yanbin
Y
Chen
Wei
W
Lei
Cheng
C
Chen
Yehan
Y
Zhu
Nan
N
Su
Chuankai
C
Zhang
Jian-An
JA
Huang
D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002177:Candidiasis / Q000188:drug therapy*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D004562:Electrocardiography; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male
D015725:Fluconazole; D000638:Amiodarone
Amiodarone; Cardiac arrest; Fluconazole