Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer.
Eag1 (ether-à-go-go-1), a member of the voltage-dependent potassium channel family, is expressed mainly in the brain, and at low levels in placenta, testis, and adrenal gland, and only transiently in myoblasts. Recently, several studies have suggested that Eag1 is selectively expressed in various tumor tissues. Eag1 plays important roles in tumor proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis. Therefore, it has become a new molecular target for tumor diagnosis, prognosis evaluation, and tumor-targeted therapy. This review provides information about the current progress in understanding Eag1 structure, electrophysiological characteristics, and role in cancer.
School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, People's Republic of China.|Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People's Republic of China.
Xuzhao
X
Wang
Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People's Republic of China.
Yafei
Y
Chen
Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People's Republic of China.
Yuhong
Y
Zhang
School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, People's Republic of China.|Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People's Republic of China.
Shuai
S
Guo
Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People's Republic of China.
Li
L
Mo
Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People's Republic of China. hailong_an@hebut.edu.cn.
Hailong
http://orcid.org/0000-0001-7947-357X
H
An
School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, People's Republic of China. yong_zhan@163.com.|Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People's Republic of China. yong_zhan@163.com.
Yong
Y
Zhan
D000818:Animals; D004594:Electrophysiology; D051638:Ether-A-Go-Go Potassium Channels / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D051638:Ether-A-Go-Go Potassium Channels; C496884:KCNH1 protein, human; D015221:Potassium Channels; D016159:Tumor Suppressor Protein p53
Cancer; Eag1; Electrophysiology; Molecular structure; p53