Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases.
"Cellular senescence" is a state in which cells undergo irreversible cell cycle arrest in response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to any mitogens, including oncogenic stimuli. Therefore, cellular senescence has been assumed to be a potent anticancer mechanism. Although irreversible cell-cycle arrest is traditionally considered the major characteristic of senescent cells, recent studies have revealed some additional functions. Most noteworthy is the increased secretion of various secretory proteins, such as inflammatory cytokines, chemokines, growth factors, and MMPs, into the surrounding extracellular fluid. These newly recognized senescent phenotypes, termed senescence-associated secretory phenotypes (SASPs), reportedly contribute to tumor suppression, wound healing, embryonic development, and even tumorigenesis promotion. Thus, SASPs appear to be beneficial or deleterious, depending on the biological context. As senescent cells are known to accumulate during the aging process in vivo, it is quite possible that their accumulation in aged tissues promotes age-associated functional decline and various diseases, including cancers, at least to some extent. Here, we focus on and discuss the functional and regulatory network of SASPs toward opening up new possibilities for controlling aging and aging-associated diseases.
Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Sugiko
http://orcid.org/0000-0002-2120-9546
S
Watanabe
Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Shimpei
S
Kawamoto
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Japan.
Naoko
N
Ohtani
Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.|The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Eiji
E
Hara
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D059447:Cell Cycle Checkpoints / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016922:Cellular Senescence / Q000235:genetics*; D004194:Disease / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D055571:Secretory Pathway / Q000235:genetics
Aging; DNA damage response; immune response; senescence; tumorigenesis