Encapsulation of testosterone by chitosan nanoparticles.
The loading of testosterone by chitosan nanoparticles was investigated, using multiple spectroscopic methods, thermodynamic analysis, TEM images and modeling. Thermodynamic parameters showed testosterone-chitosan bindings occur mainly via H-bonding and van der Waals contacts. As polymer size increased more stable steroid-chitosan conjugates formed and hydrophobic contact was also observed. The loading efficacy of testosterone-nanocarrier was 40-55% and increased as chitosan size increased. Testosterone encapsulation markedly alters chitosan morphology. Chitosan nanoparticles are capable of transporting testosterone in vitro.
Department of Chemistry-Biochemistry and Physics, University of Québec at Trois-Rivières, C. P. 500, TR, Quebec G9A 5H7, Canada.
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Department of Chemistry-Biochemistry and Physics, University of Québec at Trois-Rivières, C. P. 500, TR, Quebec G9A 5H7, Canada. Electronic address: tajmirri@uqtr.ca.
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Tajmir-Riahi
D002214:Capsules; D002236:Carbohydrate Conformation; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D062105:Molecular Docking Simulation; D053758:Nanoparticles / Q000737:chemistry*; D013739:Testosterone / Q000737:chemistry*; D013816:Thermodynamics
D002214:Capsules; D004337:Drug Carriers; D013739:Testosterone; D048271:Chitosan
Chitosan; Conjugation; Loading efficacy; TEM images; Testosterone; Thermodynamic