A supramolecular material for dual-modal imaging and targeted cancer therapy.
Recently, how to design a formulation system with simultaneous diagnosis and therapy toward cancer has attracted tremendous attention. Herein, a supramolecular material was prepared via a facile method by the co-intercalation of folic acid (FA) and doxorubicin (DOX) into the gallery of Gd3+-doped layered double hydroxides (LDHs), followed by surface adsorption of fluorescein isothiocyanate (FITC). This supramolecular agent was proved to exhibit excellent magnetic resonance imaging (MRI) and fluorescence imaging (FI) behavior, as well as chemotherapy toward cancer (KB cell). The co-intercalated FA enables an efficient and selective drug delivery with good specificity. This work provides a facile approach for the fabrication of a drug formulation with dual-modal imaging and targeted therapy, which could be potentially used in the practical chemotherapy and medical imaging.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China; Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
Shanyue
S
Guan
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: liangruizheng2000@163.com.
Ruizheng
R
Liang
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
Chunyang
C
Li
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: weimin@mail.buct.edu.cn.
Min
M
Wei
D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000628:therapy; D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans; D004317:Doxorubicin / Q000494:pharmacology*; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives; D005492:Folic Acid / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D006878:Hydroxides / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*; D014407:Tumor Cells, Cultured
D003911:Dextrans; D006878:Hydroxides; D007364:Intercalating Agents; C015219:fluorescein isothiocyanate dextran; D004317:Doxorubicin; D005492:Folic Acid; D005682:Gadolinium; D016650:Fluorescein-5-isothiocyanate
Chemotherapy; Dual-modal imaging; Supramolecular