Comparison of Amniotic Fluid Cytokine Levels in Postterm and Term Pregnancy: a Prospective Study.
BACKGROUND
To evaluate amniotic fluid pro- and anti-inflammatory cytokine levels in women with postterm and term pregnancies in labor and not in labor.


METHODS
The study involved three groups: postterm (Group 1, n = 29), term in labor (Group 2, n = 28), and control (Group 3, n = 30). All groups were compared with respect to age, gravidity, parity, obstetric history, gestation week, cervical dilatation and effacement, maternal serum C-reactive protein and white cell count, amniotic interleukin 4, 6, and 10 levels, birthweight, and cord blood pH.


RESULTS
The amniotic fluid interleukin 10 level was 24.4 ± 8.8 pg/mL in the postterm group, 13.5 ± 5.1 pg/mL in the term in labor group, and 19.8 ± 5.4 pg/mL in the control group (p < 0.001). The amniotic fluid interleukin 4 level was 86.5 ± 57.7 pg/mL in the postterm group, 38.2 ± 29.2 pg/mL in the term in labor group, and 81.9 ± 68.4 pg/mL in the control group (p = 0.002). The amniotic fluid interleukin 6 level was 329 ± 135.1 pg/mL in the postterm group, 252.8 ± 138.7 pg/mL in the term in labor group, and 227.9 ± 114.4 pg/mL in the control group (p = 0.02). There was a positive correlation between gestational age and IL-10 levels (p < 0.05).


CONCLUSIONS
Amniotic fluid IL-10 and IL-4 cytokine levels were increased in postterm pregnancy and they decreased with active labor.
Vakkas
V
Korkmaz
Yasemin
Y
Cekmez
Hatice
H
Surer
Canan D
CD
Deveci
Fatma D
FD
Ocal
Murad
M
Gezer
Zehra
Z
Kurdoglu
Yusuf
Y
Ergun
Tuncay
T
Kucukozkan
D000328:Adult; D000653:Amniotic Fluid / Q000276:immunology*; D016022:Case-Control Studies; D016207:Cytokines / Q000032:analysis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007233:Infant, Postmature; D016753:Interleukin-10 / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D011247:Pregnancy; D011273:Pregnancy, Prolonged / Q000276:immunology*; D011446:Prospective Studies; D047929:Term Birth / Q000276:immunology*; D055815:Young Adult
D016207:Cytokines; C508609:IL10 protein, human; C508598:IL4 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10; D015847:Interleukin-4