Electroencephalographic characteristics of status epilepticus after cardiac arrest.
OBJECTIVE
To describe the electrophysiological characteristics and pathophysiological significance of electrographic status epilepticus (ESE) after cardiac arrest and specifically compare patients with unequivocal ESE to patients with rhythmic or periodic borderline patterns defined as possible ESE.


METHODS
Retrospective cohort study of consecutive patients treated with targeted temperature management and monitored with simplified continuous EEG. Patients with ESE were identified and electrographically characterised until 72h after ESE start using the standardised terminology of the American Clinical Neurophysiology Society.


RESULTS
ESE occurred in 41 of 127 patients and 22 fulfilled the criteria for unequivocal ESE, which typically appeared early and transiently. Three of the four survivors had unequivocal ESE, starting after rewarming from a continuous background. There were no differences between the groups of unequivocal ESE and possible ESE regarding outcome, neuron-specific enolase levels or prevalence of reported clinical convulsions.


CONCLUSIONS
ESE is common after cardiac arrest. The distinction between unequivocal and possible ESE patterns was not reflected by differences in clinical features or survival.


CONCLUSIONS
A favourable outcome is seen infrequently in patients with ESE, regardless of using strict or liberal ESE definitions.
Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Clinical Neurophysiology, Lund, Sweden. Electronic address: sofia.backman@med.lu.se.
Sofia
S
Backman
Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Clinical Neurophysiology, Lund, Sweden.
Erik
E
Westhall
Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Neurology, Lund, Sweden.
Irina
I
Dragancea
Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Intensive and Perioperative Care, Lund, Sweden.
Hans
H
Friberg
Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Intensive and Perioperative Care, Lund, Sweden.
Malin
M
Rundgren
Clinical Studies Sweden - Forum South, Skane University Hospital, Lund, Sweden.
Susann
S
Ullén
Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Neurology, Lund, Sweden.
Tobias
T
Cronberg
D000368:Aged; D004569:Electroencephalography; D005260:Female; D006323:Heart Arrest / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013226:Status Epilepticus / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
Cardiac arrest; Coma; Continuous EEG monitoring; EEG; Electrographic status epilepticus; Hypoxic-ischemic encephalopathy; Outcome prediction; Therapeutic hypothermia