Near-critical GLUT1 and Neurodegeneration.
Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity. We discuss how the architecture of the blood-brain barrier and the low concentration of glucose within neurons combine to make endothelial/glial GLUT1 the master controller of neuronal glucose utilization, while the regulatory role of the neuronal glucose transporter GLUT3 emerges as secondary. The near-critical condition of glucose dynamics in the brain suggests that subtle deficits in GLUT1 function or its activity-dependent control by neurons may contribute to neurodegeneration. © 2017 Wiley Periodicals, Inc.
Centro de Estudios Científicos, Valdivia, Chile.
L Felipe
LF
Barros
Centro de Estudios Científicos, Valdivia, Chile.
Alejandro
A
San Martín
Centro de Estudios Científicos, Valdivia, Chile.
Ivan
I
Ruminot
Centro de Estudios Científicos, Valdivia, Chile.
Pamela Y
PY
Sandoval
Centro de Estudios Científicos, Valdivia, Chile.|Universidad Austral de Chile, Valdivia, Chile.
Ignacio
I
Fernández-Moncada
Centro de Estudios Científicos, Valdivia, Chile.|Universidad Austral de Chile, Valdivia, Chile.
Felipe
F
Baeza-Lehnert
Centro de Estudios Científicos, Valdivia, Chile.|Universidad Austral de Chile, Valdivia, Chile.
Robinson
R
Arce-Molina
Centro de Estudios Científicos, Valdivia, Chile.
Yasna
Y
Contreras-Baeza
Centro de Estudios Científicos, Valdivia, Chile.
Francisca
F
Cortés-Molina
Centro de Estudios Científicos, Valdivia, Chile.
Alex
A
Galaz
Centro de Estudios Científicos, Valdivia, Chile.
Karin
K
Alegría
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004734:Energy Metabolism / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D051272:Glucose Transporter Type 1 / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology
D051272:Glucose Transporter Type 1; D005947:Glucose
Alzheimer disease; GLUT1 deficiency; Slc2a1; astrocyte; endothelium; glucose transporter