Pregnancy in fanconi anaemia with bone marrow failure: a case report and review of the literature.
Fanconi anaemia is a rare inherited disease characterized by congenital abnormalities, progressive bone marrow failure and predisposition to malignancy. Successful pregnancies in transplanted patients have been reported. In this paper we will describe the pregnancy of a patient with Fanconi anaemia without transplantation.



A 34-year-old nulliparous woman with Fanconi anaemia was referred to our institution. Pregnancy was complicated by progressive pancytopenia and two severe infections. C-section was performed at 36 weeks. Both infant and mother are well.



Successful pregnancy in a Fanconi anaemia patient with bone marrow failure is possible. The mode of delivery in patients with bone marrow failure should be determined by obstetric indications. The case highlights the safe outcome of the pregnancy with strict clinical and laboratory control by a multidisciplinary team.
Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy. flasorbi@gmail.com.
Flavia
0000-0001-7277-6420
F
Sorbi
Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy.
Federico
F
Mecacci
Department of Health Sciences - Division of Anaesthesiology, University of Florence, Careggi University Hospital, Florence, Italy.
Alessandro
A
Di Filippo
Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy.
Massimiliano
M
Fambrini
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy; D001855:Bone Marrow Diseases / Q000628:therapy*; D002169:Campylobacter Infections / Q000188:drug therapy; D002585:Cesarean Section; D016640:Diabetes, Gestational / Q000628:therapy*; D003927:Diet, Diabetic; D017707:Erythrocyte Transfusion; D004927:Escherichia coli Infections / Q000188:drug therapy; D005199:Fanconi Anemia / Q000628:therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D009503:Neutropenia / Q000628:therapy; D010198:Pancytopenia / Q000628:therapy*; D017713:Platelet Transfusion; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011645:Puerperal Infection / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy; D013921:Thrombocytopenia / Q000628:therapy
D000900:Anti-Bacterial Agents; D007004:Hypoglycemic Agents; D007328:Insulin
Antenatal care; Fanconi Anaemia; High-risk pregnancy