Laparoscopic Versus Open Liver Resection for Colorectal Metastases in Elderly and Octogenarian Patients: A Multicenter Propensity Score Based Analysis of Short- and Long-term Outcomes.
This study aims to compare the perioperative and oncological outcomes of laparoscopic and open liver resection for colorectal liver metastases in the elderly.



Laparoscopic liver resection has been associated with less morbidity and similar oncological outcomes to open liver resection for colorectal liver metastases (CRLMs). It has been reported that these benefits continue to be observed in elderly patients. However, in previous studies, patients over 70 or 75 years were considered as a single, homogenous population raising questions regarding the true impact of the laparoscopic approach on this diverse group of elderly patients.



Prospectively maintained databases of all patients undergoing liver resection for CRLM in 5 tertiary liver centers were included. Those over 70-years old were selected for this study. The cohort was divided in 3 subgroups based on age. A comparative analysis was performed after the implementation of propensity score matching on the 2 main cohorts (laparoscopic and open groups) and also on the study subgroups.



A total of 775 patients were included in the study. After propensity score matching 225 patients were comparable in each of the main groups. Lower blood loss (250 vs 400 mL, P = 0.001), less overall morbidity (22% vs 39%, P = 0.001), shorter High Dependency Unit (2 vs. 6 days, P = 0.001), and total hospital stay (5 vs. 8 days, P = 0.001) were observed after laparoscopic liver resection. Comparable rates of R0 resection (88% vs 88%, P = 0.999), median recurrence-free survival (33 vs 27 months, P = 0.502), and overall survival (51 vs 45 months, P = 0.671) were observed. The advantages seen with the laparoscopic approach were reproduced in the 70 to 74-year old subgroup; however there was a gradual loss of these advantages with increasing age.



In patients over 70 years of age laparoscopic liver resection, for colorectal liver metastases, offers significant lower morbidity, and a shorter hospital stay with comparable oncological outcomes when compared with open liver resection. However, the benefits of the laparoscopic approach appear to fade with increasing age, with no statistically significant benefits in octogenarians except for a lower High Dependency Unit stay.
*University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom †Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy ‡Department of Minimally Invasive Digestive Surgery, Antoine-Beclere Hospital, Clamart, France §Department of General, Hepatobiliary and Liver Transplantation Surgery, Ghent University Hospital Medical School, Ghent, Belgium ¶Department of Gastrointestinal and Hepatobiliary Surgery, Oslo University Hospital and Institute of Clinical Medicine, Oslo, Norway ||Section for Clinical Research, Interventional Center, Oslo University Hospital, Oslo, Norway.
David
D
Martínez-Cecilia
Federica
F
Cipriani
Vishal
V
Shelat
Francesca
F
Ratti
Hadrien
H
Tranchart
Leonid
L
Barkhatov
Federico
F
Tomassini
Roberto
R
Montalti
Mark
M
Halls
Roberto I
RI
Troisi
Ibrahim
I
Dagher
Luca
L
Aldrighetti
Bjorn
B
Edwin
Mohammad
M
Abu Hilal
D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D007902:Length of Stay; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications; D057216:Propensity Score; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome