Correlation of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with thrombolysis in myocardial infarction frame count in ST-segment elevation myocardial infarction.
BACKGROUND
Impaired coronary artery reflow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction has been associated with postintervention adverse effects. Thus, finding an easily achievable index would be of great value to predict no-reflow phenomenon. In this regard, platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been introduced. In this study, we aimed to investigate correlation of PLR and NLR with thrombolysis in myocardial infarction (TIMI) frame count.


METHODS
A total of 215 consecutive patients with ST-segment elevation myocardial infarction (STEMI) were recruited. Pre-intervention laboratory tests were performed. Moreover, PLR and NLR were calculated for each patient. Ultimately, TIMI frame count was assessed subsequent to primary PCI for each patient.


RESULTS
We found that both PLR and NLR are correlated with TIMI frame count (R: 0·372, P < 0·001 and R: 0·301, P < 0·001, respectively). Furthermore, it was revealed that both PLR and NLR are positively correlated with corrected TIMI frame count (R: 0·388, P < 0·001 and R: 0·290, P < 0·001, respectively).


CONCLUSIONS
PLR and NLR are two easily calculated and efficient indexes for predicting the no-reflow phenomenon in patients with STEMI undergoing PPCI. Therefore, they might be employed in accurate risk stratification when a patient is a candidate for PPCI and in accurately referring patients who would benefit greatly from PPCI.
Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein
H
Vakili
Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahin
M
Shirazi
Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahsa
M
Charkhkar
Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Isa
I
Khaheshi
Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehdi
M
Memaryan
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.|Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza
M
Naderian
D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D054318:No-Reflow Phenomenon / Q000175:diagnosis*; D062645:Percutaneous Coronary Intervention; D000072657:ST Elevation Myocardial Infarction / Q000503:physiopathology / Q000601:surgery*; D015912:Thrombolytic Therapy / Q000379:methods
Angioplasty; blood platelets; lymphocytes; neutrophil-to-lymphocyte ratio; neutrophils; percutaneous transluminal; platelet-to-lymphocyte ratio