[Factors related with post-surgical complications in elderly patients with glioblastoma multiforme].
BACKGROUND
Glioblastoma multiforme is the most frequent malignant tumour of the central nervous system, and its incidence reaches 80% in those over 50 years of age. Life expectancy has increased in the population in recent times and an analysis of the post-surgical complications affecting elderly patients is of great importance for a correct surgical indication.


OBJECTIVE
To analyse the factors related with post-surgical complications in elderly patients.


METHODS
A sample of 88 patients diagnosed with glioblastoma multiforme between 31 and 78 years of age was analysed retrospectively. The variables taken into consideration in the study were: personal medical history, age, functional status, pre-anaesthetic status, tumour characteristics, type of surgery and post-surgical complications.


RESULTS
Age was observed to have an influence on local (p = 0.006) and systemic surgical complications (p = 0.034), and on the Clavien-Dindo scale (p = 0.001). Persons with a poorer functional status and cardiovascular risk presented more systemic complications (p = 0.006 and 0.044) and a lower score on the Clavien-Dindo scale (p = 0.024 and 0.025) respectively. Likewise, more local complications are found in the case of excisional procedures than in biopsies (p = 0.027). The pre-anaesthetic status and anti-haemostatic treatments were not related with such events.


CONCLUSIONS
Patients over 65 years of age present a higher incidence of pathological antecedents and a poorer pre-surgical functional status. Age, cardiovascular risk, functional status and the type of surgical procedure have significantly increased the occurrence of post-surgical complications.
Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Espana.
M
M
Martin-Risco
Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Espana.
V
V
Rodrigo-Paradells
Clinica del Hospital Clinico Lozano Blesa, Zaragoza, Espana.
S
S
Olivera-Gonzalez
Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Espana.
C M
CM
Del Rio-Perez
Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Espana.
L
L
Bances-Florez
Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Espana.
J B
JB
Calatayud-Perez
Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Espana.
F J
FJ
Villagrasa-Compaired
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000145:classification / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D012189:Retrospective Studies; D012306:Risk; D012720:Severity of Illness Index