Increased serum renalase in peritoneal dialysis patients: Is it related to cardiovascular disease risk?
BACKGROUND
Renalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Epicardial adipose tissue (EAT) has been found to correlate with cardiovascular diseases (CVD) in dialysis patients. The present study aimed to evaluate the association of serum renalase levels with EAT thickness and other CVD risk factors in peritoneal dialysis (PD) patients.


METHODS
The study included 40 PD patients and 40 healthy controls. All subjects underwent blood pressure and anthropometric measurements. Serum renalase was assessed by using a commercially available assay. Transthoracic echocardiography was used to measure EAT thickness and left ventricular mass index (LVMI) in all subjects.


RESULTS
The median serum renalase level was significantly higher in the PD patients than in the control group [176.5 (100-278.3) vs 122 (53.3-170.0)ng/ml] (p=0.001). Renalase was positively correlated with C-reactive protein (r=0.705, p<0.001) and negatively correlated with RRF (r=-0.511, p=0.021). No correlation was observed between renalase and EAT thickness or LVMI. There was a strong correlation between EAT thickness and LVMI in both the PD patients and the controls (r=0.848, p<0.001 and r=0.640, p<0.001 respectively).


CONCLUSIONS
This study indicates that renalase is associated with CRP and residual renal function but not with EAT thickness as CVD risk factors in PD patients.
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey. Electronic address: ebrugokoguz@hotmail.com.
Ebru
E
Gok Oguz
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Hadim
H
Akoglu
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Gulay
G
Ulusal Okyay
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Guner
G
Karaveli Gursoy
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Tolga
T
Yildirim
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Ozgur
O
Merhametsiz
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
Tolga
T
Cimen
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Basol
B
Canbakan
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
Ekrem
E
Yeter
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
M Deniz
MD
Ayli
D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D009929:Organ Size; D010496:Pericardium / Q000473:pathology; D010530:Peritoneal Dialysis; D012307:Risk Factors
D008995:Monoamine Oxidase; C521557:renalase
C-reactive protein; Diálisis peritoneal; Epicardial adipose tissue thickness; Espesor del tejido adiposo epicárdico; Hipertrofia ventricular izquierda; Left ventricular hypertrophy; Peritoneal dialysis; Proteína C reactiva; Renalasa; Renalase