Association of Fucosyltransferase 2 Gene Polymorphisms with Inflammatory Bowel Disease in Patients from Southeast China.
Aims. Fucosyltransferase 2 (FUT2) gene potentially affects the constituent of intestinal microbiota, which play a crucial role in the pathogenesis of inflammatory bowel disease (IBD). This study investigated the association ofFUT2gene polymorphisms with IBD in southeast China.Methods. We collected 671 IBD patients and 502 healthy controls.FUT2gene polymorphisms (C357T, A385T, and G428A) were determined by SNaPshot. Frequencies of theFUT2genotypes, alleles, and haplotype between groups were compared byχ2test.Results. The allele and genotype frequencies ofFUT2did not differ between ulcerative colitis patients and controls (allP> 0.05). However, mutant allele and genotype ofFUT2(A385T) were significantly increased in Crohn's disease (CD) patients (P= 0.024, OR = 1.271, and 95% CI = 1.031-1.565;P< 0.001, OR = 1.927, and 95% CI = 1.353-2.747, resp.). The same conclusion was drawn fromFUT2(G428A) (P= 0.023, OR = 3.324, and 95% CI = 1.108-9.968;P= 0.044, OR = 1.116-10.137, and 95% CI = 1.116-10.137, resp.). The haplotype TT formed with "C357T and A385T" was more prevalent in CD patients than in controls (P= 0.020, OR = 1.277, and 95% CI = 1.036-1.573). Besides, frequencies of mutant allele and genotype ofFUT2(A385T) were significantly lower in patients with ileocolonic CD than in those with colonic CD (P= 0.001 and 0.002, resp.) and ileal CD (P= 0.007 and 0.004, resp.).Conclusions.FUT2gene polymorphisms and haplotypes were associated with the susceptibility to CD but not UC.
Qilu Hospital, Shandong University, Ji'nan, Shandong 250012, China; Department of Gastroenterology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Hao
H
Wu
Department of Gastroenterology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Liang
L
Sun
Department of Gastroenterology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Dao-Po
DP
Lin
Department of Gastroenterology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Xiao-Xiao
XX
Shao
Department of Gastroenterology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Sheng-Long
SL
Xia
Qilu Hospital, Shandong University, Ji'nan, Shandong 250012, China.
Ming
0000-0002-8685-6322
M
Lv