Lipopolysaccharide induced vascular smooth muscle cells proliferation: A new potential therapeutic target for proliferative vascular diseases.
Vascular smooth muscle cells (VSMCs) proliferation is involved in vascular atherosclerosis and restenosis. Recent studies have demonstrated that lipopolysaccharide (LPS) promotes VSMCs proliferation, but the signalling pathways which are involved are not completely understood. The purpose of this review was to summarize the existing knowledge of the role and molecular mechanisms involved in controlling VSMCs proliferation stimulated by LPS and mediated by toll-like receptor 4 (TLR4) signalling pathways. Moreover, the potential inhibitors of TLR4 signalling for VSMCs proliferation in proliferative vascular diseases are discussed.
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Dehua
http://orcid.org/0000-0001-8517-1623
D
Jiang
Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Yu
Y
Yang
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China.|Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Dongye
D
Li
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D051197:Toll-Like Receptor 4 / Q000378:metabolism
D008070:Lipopolysaccharides; D051197:Toll-Like Receptor 4
lipopolysaccharide; proliferation; signaling pathways; vascular smooth muscle cells