Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes.
An efficient system for direct delivery of integral membrane proteins is successfully developed using a new biocompatible exosome-based platform. Fusogenic exosomes harboring viral fusogen, vascular stomatitis virus (VSV)-G protein, can fuse with and modify plasma membranes in a process called "membrane editing." This can facilitate the transfer of biologically active membrane proteins into the target cell membranes both in vitro and in vivo.
Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Yoosoo
Y
Yang
Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.|KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Yeonsun
Y
Hong
Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.|KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Gi-Hoon
GH
Nam
Bio-Imaging Center, Asan Institute for Life Science, Asan Medical Center, Seoul, 05505, Republic of Korea.
Jin Hwa
JH
Chung
Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.|KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Eunee
E
Koh
Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.|KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
In-San
IS
Kim
D000818:Animals; D001691:Biological Therapy / Q000379:methods; D040761:Biomimetic Materials / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis; D055354:Exosomes / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000378:metabolism; D008565:Membrane Proteins / Q000008:administration & dosage* / Q000378:metabolism; D051379:Mice; D018482:Muscle, Skeletal / Q000166:cytology / Q000000981:diagnostic imaging / Q000378:metabolism; D011092:Polyethylene Glycols / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014780:Viruses
D008081:Liposomes; D008565:Membrane Proteins; D014764:Viral Proteins; D049452:Green Fluorescent Proteins; D011092:Polyethylene Glycols
exosomes; membrane protein; nanoplatform; viral fusogen