Thymoma and Synchronous Primary Mediastinal Seminomas with Florid Follicular Lymphoid Hyperplasia in the Anterior Mediastinum: A Case Report and Review of the Literature.
Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously. The patient underwent a thymectomy for the removal of the mediastinal masses, one of which was diagnosed as type B2 invasive thymoma, and two of which were diagnosed as primary mediastinal seminomas with massive follicular hyperplasia. The patient received adjuvant chemotherapy after surgical resection. To our knowledge, this is the first description of a thymoma and a mediastinal seminoma occurring simultaneously in the thymus. We present this case along with a literature review.
Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Hyang-Im
HI
Lee
Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University Hospital, Jinju, Korea.|Gyeongsang National University School of Medicine, Jinju, Korea.|Institute of Health Science, Gyeongsang National University, Jinju, Korea.
In-Seok
IS
Jang
Gyeongsang National University School of Medicine, Jinju, Korea.|Institute of Health Science, Gyeongsang National University, Jinju, Korea.|Department of Radiology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Kyung Nyeo
KN
Jeon
Gyeongsang National University School of Medicine, Jinju, Korea.|Institute of Health Science, Gyeongsang National University, Jinju, Korea.|Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Gyung Hyuck
GH
Ko
Gyeongsang National University School of Medicine, Jinju, Korea.|Institute of Health Science, Gyeongsang National University, Jinju, Korea.|Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Jong Sil
JS
Lee
Gyeongsang National University School of Medicine, Jinju, Korea.|Institute of Health Science, Gyeongsang National University, Jinju, Korea.|Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Dong Chul
DC
Kim
Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea.|Gyeongsang National University School of Medicine, Jinju, Korea.
Dae Hyun
DH
Song
Gyeongsang National University School of Medicine, Jinju, Korea.|Institute of Health Science, Gyeongsang National University, Jinju, Korea.|Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Jeong-Hee
JH
Lee
Follicular hyperplasia; Mediastinum; Seminoma; Thymoma