Plasma levels of miR-137 and miR-124 are associated with Parkinson's disease but not with Parkinson's disease with depression.
MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Recently, it was reported that miR-137, miR-124, and miR-184 were widely expressed in the central nervous system and were vital to neuronal regulation. In this study, we detected the circulating levels of miR-137, miR-124, and miR-184 in PD patients, and explored the potential role of miR-124, miR-137, and miR-184 in the diagnosis of PD. We further described the relationship between these miRNAs and PD with depression (PD-Dep). The study recruited 60 controls and 60 PD patients, which were further divided into two subgroups, PD with depression (PD-Dep, n = 24) and non-depressed group (PD-NDep, n = 36) according to Hamilton Rating Scale for Depression. Plasma levels of miR-137, miR-124, and miR-184 were detected by qRT-PCR. Receiver-operating characteristic (ROC) curve was used to evaluate miR-124 and miR-137 levels as potential diagnostic biomarkers for PD. The results demonstrated that there were no significant differences in levels of miR-184 between PD patients and controls (p > 0.05). However, miR-137 levels were increased significantly for PD patients compared to controls (p < 0.05), while miR-124 levels were down-regulated (p < 0.05). The areas under the ROC curve (AUC) of miR-137 and miR-124 were 0.707 (95% CI 0.615-0.789, p < 0.05) and 0.709 (95% CI 0.618-0.633, p < 0.05), respectively. Correlation analysis revealed that there was no relationship between these two miRNAs levels and UPDRS scores or H&Y stage. There were no significant differences in miR-137 and miR-124 levels between PD-Dep and PD-NDep (p > 0.05). Thus, plasma levels of miR-137 and miR-124 are associated with Parkinson's disease and might be potential biomarkers of the diagnosis of PD. There were no associations of plasma miR-137 and miR-124 with the severity of PD motor symptoms or PD-Dep.
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People's Republic of China.
Na
N
Li
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People's Republic of China.
Xudong
X
Pan
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People's Republic of China.
Jingli
J
Zhang
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People's Republic of China. drmaj@126.com.
Aijun
A
Ma
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People's Republic of China.
Shaonan
S
Yang
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People's Republic of China.
Juanjuan
J
Ma
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People's Republic of China.
Anmu
A
Xie
D000368:Aged; D003863:Depression / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000150:complications*; D011569:Psychiatric Status Rating Scales; D012333:RNA, Messenger / Q000378:metabolism; D012372:ROC Curve; D012189:Retrospective Studies
C509207:MIRN124 microRNA, human; C545567:MIRN137 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger
Depression; Non-motor symptoms; PD; Plasma; miRNA