Long-term prognostic role of CA-125 in noncongestive patients undergoing a cardiac transplantation.
OBJECTIVE
To evaluate the possible relationship between high levels of CA-125 and long-term prognosis in chronic heart failure patients after they undergo a cardiac transplantation (CT).


METHODS
We retrospectively studied all patients who underwent a CT and had a previous determination of CA-125. Congestive patients and those whose survival was <1 year after CT were excluded.


RESULTS
Of 55 patients, 23 had elevated CA-125 levels (>35 U/ml). After CT, survival was significantly inferior in this group (96.3 vs 81%, 84.9 vs 64%, 70.7 vs 32.9% at 2, 5 and 8 years, p = 0.014). CA-125 >35 U/ml was the only factor independently associated to long-term mortality (OR: 3.94; 95% CI: 1.2-12.82; p = 0.023).


CONCLUSIONS
Noncongestive patients with high levels of CA-125 had inferior long-term survival after CT.
Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), CIBERCV Enfermedades Cardiovasculares, Málaga, Spain.
Víctor Manuel
VM
Becerra-Muñoz
Unidad de Insuficiencia Cardiaca y Trasplante Cardiaco, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
José Manuel
JM
Sobrino-Márquez
Unidad de Insuficiencia Cardiaca y Trasplante Cardiaco, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Diego
D
Rangel-Sousa
Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Agustín
A
Fernández-Cisnal
Unidad de Insuficiencia Cardiaca y Trasplante Cardiaco, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Ernesto
E
Lage-Gallé
Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), CIBERCV Enfermedades Cardiovasculares, Málaga, Spain.
José Manuel
JM
García-Pinilla
Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Ángel
Á
Martínez-Martínez
Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), CIBERCV Enfermedades Cardiovasculares, Málaga, Spain.
Eduardo
E
de Teresa-Galván
D000328:Adult; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000175:diagnosis* / Q000401:mortality; D006333:Heart Failure / Q000628:therapy*; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
D015415:Biomarkers; D018394:CA-125 Antigen
CA-125; carbohydrate antigen 125; cardiac transplantation; graft rejection; heart failure; prognosis; survival; tumor markers