Klyflaccisteroids K-M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum.
New steroids, klyflaccisteroids K-M (1-3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2-) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Yi-Ying
YY
Tsai
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Chiung-Yao
CY
Huang
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Wan-Ru
WR
Tseng
Department of Biochemistry, University of Toronto, Toronto M5G2R3, Canada.
Pei-Lun
PL
Chiang
Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
Tsong-Long
TL
Hwang
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
Jui-Hsin
JH
Su
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
Ping-Jyun
PJ
Sung
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan.
Chang-Feng
CF
Dai
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan; Graduate Institute of Natural Products, School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. Electronic address: sheu@mail.nsysu.edu.tw.
Jyh-Horng
JH
Sheu
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009504:Neutrophils / Q000187:drug effects*; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology; D013481:Superoxides / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D013256:Steroids; C000623089:klyflaccisteroid K; C000623090:klyflaccisteroid L; D013481:Superoxides
Anti-inflammatory activity; Cytotoxicity; Klyflaccisteroid; Klyxum flaccidum; Steroid