Building the Class 2 CRISPR-Cas Arsenal.
Adaptation of CRISPR-Cas9 for genome-editing applications has revolutionized biomedical research. New single-component effector CRISPR systems are emerging from the bioinformatics pipeline. How can we best harness their power? Three new studies will no doubt facilitate this transition by generating the C2c1 and C2c2 structure snapshots in different functional states.
Department of Molecular Biology and Genetics, Cornell University, 251 Biotechnology Building, Ithaca, NY 14853, USA.
Kevin M
KM
Lewis
Department of Molecular Biology and Genetics, Cornell University, 251 Biotechnology Building, Ithaca, NY 14853, USA. Electronic address: ailong.ke@cornell.edu.
Ailong
A
Ke
D064130:CRISPR-Associated Proteins / Q000737:chemistry; D064113:CRISPR-Cas Systems; D000072669:Gene Editing / Q000379:methods*; D005818:Genetic Engineering / Q000379:methods; D008958:Models, Molecular
D064130:CRISPR-Associated Proteins
C2c1; C2c2; C2c3; CRISPR; Cas; Cas9; Cpf1; immunity; interference; type II