Multilayer porous UHMWPE scaffolds for bone defects replacement.
Reconstruction of the structural integrity of the damaged bone tissue is an urgent problem. UHMWPE may be potentially used for the manufacture of porous implants simulating as closely as possible the porous cancellous bone tissue. But the extremely high molecular weight of the polymer does not allow using traditional methods of foaming. Porous and multilayer UHMWPE scaffolds with nonporous bulk layer and porous layer that mimics cancellous bone architecture were obtained by solid-state mixing, thermopressing and washing in subcritical water. Structural and mechanical properties of the samples were studied. Porous UHMWPE samples were also studied in vitro and in vivo. The pores of UHMWPE scaffold are open and interconnected. Volume porosity of the obtained samples was 79±2%; the pore size range was 80-700μm. Strong connection of the two layers in multilayer UHMWPE scaffolds was observed with decreased number of fusion defects. Functionality of implants based on multilayer UHMWPE scaffolds is provided by the fixation of scaffolds in the bone defect through ingrowths of the connective tissue into the pores, which ensures the maintenance of the animals' mobility.
National University of Science and Technology "MISIS", Moscow, Russian Federation.
A V
AV
Maksimkin
National University of Science and Technology "MISIS", Moscow, Russian Federation. Electronic address: senatov@misis.ru.
F S
FS
Senatov
National University of Science and Technology "MISIS", Moscow, Russian Federation; N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation.
N Yu
NY
Anisimova
National University of Science and Technology "MISIS", Moscow, Russian Federation; N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation.
M V
MV
Kiselevskiy
State Plant of Medicinal Drugs, Moscow, Russian Federation.
D Yu
DY
Zalepugin
State Plant of Medicinal Drugs, Moscow, Russian Federation.
I V
IV
Chernyshova
State Plant of Medicinal Drugs, Moscow, Russian Federation.
N A
NA
Tilkunova
National University of Science and Technology "MISIS", Moscow, Russian Federation.
S D
SD
Kaloshkin
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008810:Mice, Inbred C57BL; D011095:Polyethylenes / Q000494:pharmacology*; D016062:Porosity; D019919:Prosthesis Implantation; D051381:Rats; D040521:Subcutaneous Tissue / Q000187:drug effects; D013977:Tibia / Q000187:drug effects / Q000473:pathology; D054457:Tissue Scaffolds / Q000737:chemistry*
D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene
Biocompatibility; Bone defects; Multilayer; Scaffold; UHMWPE