Are Mesenchymal Stem Cells So Bloody Great After All?
This Perspective discusses some activities of mesenchymal stem cells (MSCs) in the context of angiogenesis, focusing on contrasting effects that could call into question the extent to which MSCs can be used clinically in the future. We report on the antiangiogenic/antiproliferative effects of specific MSC populations (including bone marrow MSCs), their paracrine activity, tissue heterogeneity, and endothelial cell interactions. Also discussed are what could lead to contrasting effects of the influence of MSCs in regulating angiogenesis, pointing to some negative effects of these cells. In conclusion, this article highlights important aspects of MSC behavior within the perspective of translational medicine applications. Stem Cells Translational Medicine 2017;6:3-6.
Biological Sciences, University of Southampton, Southampton, United Kingdom.
Stephanie J
SJ
Marfy-Smith
Biological Sciences, University of Southampton, Southampton, United Kingdom.
Claire E
CE
Clarkin
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002450:Cell Communication; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D018919:Neovascularization, Physiologic