Potentiation of the Fosmidomycin analogue FR 900098 with substituted 2-oxazolines againstFrancisella novicida.
A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against theFrancisella tularensissurrogateFrancisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against theFrancisellasub-speciesF. novicidaandF. philomiragia.
Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, NC 27695, USA.
Matthew D
MD
Stephens
Department of Chemistry, Mahidol University, 999 Phuttamonthon 4 Road, Salaya 73170, Thailand.
Nisakorn
N
Yodsanit
Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, NC 27695, USA.
Christian
C
Melander