Can MDCT or EUS features predict the histopathological grading scheme of pancreatic neuroendocrine neoplasms?
OBJECTIVE
To identify whether the features of preoperative MDCT or EUS could predict the histopathological grading scheme of pancreatic neuroendocrine neoplasms (pNENs).


METHODS
A total of 25 patients with pNENs were enrolled in the present study. The qualitative and quantitative variables were reviewed. The qualitative variables included location, contour, border, necrosis, intratumoral vessel, homogeneity, calcification, peripancreatic fat/vessel infiltration, pancreatic duct dilatation, mass within pancreas, lymphadenopathy and hepatic metastasis on MDCT and border, echogenicity, cystic/solid and blood flow on EUS. The quantitative variables included long diameter (LD), short diameter (SD), unenhanced mass attenuation (UMA), unenhanced pancreatic attenuation (UPA), arterial phase mass attenuation (APMA), arterial phase pancreatic attenuation (APPA), portal venous phase mass attenuation (PVPMA), portal venous phase pancreatic attenuation (PVPPA), arterial phase enhancement degree (APED) and portal venous phase enhancement degree (PVPED). In addition, sex and age were also evaluated. Histopathological classifications met the criterion of 2010 edition WHO Histopathological Classifications. Kruskal-Wallis test and Boruta algorithm were conducted.


RESULTS
Lymphadenopathy and peripancreatic fat or vascular invasion foretold higher histopathological grading level while well-defined border on EUS image lower grading level.


CONCLUSIONS
Lymphadenopathy, border on EUS image and peripancreatic fat or vascular invasion can predict the histopathological grading scheme of pNENs.
Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai, 200032, China.
Hui
H
Zhu
Department of Orthopaedics, Yancheng Third People's Hospital, The Affiliated Yancheng Hospital of Southeast University Medical College, 75 JuChang Road, Yancheng, 224001, China.
Lang
L
Ying
Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai, 200032, China.
Wei
W
Tang
Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai, 200032, China.|Department of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai, China.
Xiujiang
X
Yang
Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai, 200032, China. gidrsunbo@126.com.|Department of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai, China. gidrsunbo@126.com.
Bo
B
Sun
D000328:Adult; D000368:Aged; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D060787:Neoplasm Grading; D018358:Neuroendocrine Tumors / Q000188:drug therapy* / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies
Endosonography; Multi-detector computed tomography (MDCT); Pancreatic neuroendocrine neoplasms; Pathological classification; Prognosis