Effect of magnesium supplementation on lipid profile: a systematic review and meta-analysis of randomized controlled trials.
OBJECTIVE
We performed a meta-analysis of randomized controlled trials (RCTs) in order to evaluate the effect of oral magnesium supplementation on lipid profile of both diabetic and non-diabetic individuals.


METHODS
PubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases were searched (from inception to February 23, 2016) to identify RCTs evaluating the effect of magnesium on lipid concentrations. A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations.


RESULTS
Magnesium treatment was not found to significantly affect plasma concentrations of any of the lipid indices including total cholesterol (WMD 0.03 mmol/L, 95% CI -0.11, 0.16, p = 0.671), LDL-C (WMD -0.01 mmol/L, 95% CI -0.13, 0.11, p = 0.903), HDL-C (WMD 0.03 mmol/L, 95% CI -0.003, 0.06, p = 0.076), and triglycerides concentrations (WMD -0.10 mmol/L, 95% CI -0.25, 0.04, p = 0.149). In a subgroup analysis comparing studies with and without diabetes, no difference was observed between subgroups in terms of changes in plasma total cholesterol (p = 0.924), LDL-C (p = 0.161), HDL-C (p = 0.822), and triglyceride (p = 0.162) concentrations.


CONCLUSIONS
Results of the present meta-analysis indicated that magnesium supplementation showed no significant effects on the lipid profile of either diabetic or non-diabetic individuals.
Biomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico.
Luis E
LE
Simental-Mendía
Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, NL, Mexico.
Mario
M
Simental-Mendía
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Amirhossein
A
Sahebkar
Biomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico.
Martha
M
Rodríguez-Morán
Biomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico. guerrero.romero@gmail.com.
Fernando
F
Guerrero-Romero
D006801:Humans; D008055:Lipids / Q000097:blood*; D008274:Magnesium / Q000008:administration & dosage*; D017594:Publication Bias; D016032:Randomized Controlled Trials as Topic
D008055:Lipids; D008274:Magnesium
Cholesterol; HDL-cholesterol; Lipid profile; Magnesium; Meta-analysis; Triglycerides