Degradation in the fatigue crack growth resistance of human dentin by lactic acid.
The oral cavity frequently undergoes localized changes in chemistry and level of acidity, which threatens the integrity of the restorative material and supporting hard tissue. The focus of this study was to evaluate the changes in fatigue crack growth resistance of dentin and toughening mechanisms caused by lactic acid exposure. Compact tension specimens of human dentin were prepared from unrestored molars and subjected to Mode I opening mode cyclic loads. Fatigue crack growth was achieved in samples from mid- and outer-coronal dentin immersed in either a lactic acid solution or neutral conditions. An additional evaluation of the influence of sealing the lumens by dental adhesive was also conducted. A hybrid analysis combining experimental results and finite element modeling quantified the contribution of the toughening mechanisms for both environments. The fatigue crack growth responses showed that exposure to lactic acid caused a significant reduction (p≤0.05) of the stress intensity threshold for cyclic crack extension, and a significant increase (p≤0.05) in the incremental fatigue crack growth rate for both regions of coronal dentin. Sealing the lumens had negligible influence on the fatigue resistance. The hybrid analysis showed that the acidic solution was most detrimental to the extrinsic toughening mechanisms, and the magnitude of crack closure stresses operating in the crack wake. Exposing dentin to acidic environments contributes to the development of caries, but it also increases the chance of tooth fractures via fatigue-related failure and at lower mastication forces.
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Hopkins Extreme Materials Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Santiago
S
Orrego
Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA.
Huakun
H
Xu
Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA; Department of Restorative Dentistry, School of Dentistry, University of Washington, Seattle, WA 98195, USA; Department of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA 98195, USA. Electronic address: darola@uw.edu.
Dwayne
D
Arola
D000293:Adolescent; D000328:Adult; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D020342:Finite Element Analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000494:pharmacology*; D008963:Molar / Q000187:drug effects; D013314:Stress, Mechanical; D055815:Young Adult
D019344:Lactic Acid
Acid; Cyclic crack growth; Demineralization; Dentin; Fatigue; Fracture toughness