Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited.
BACKGROUND
Cutaneous leiomyosarcoma (CLM) is a rare soft tissue tumor of smooth muscle derivation. We report the clinical treatment, long-term outcomes, and prognostic findings of CLM in our institution.


METHODS
We revisited and carried out a retrospective chart review of 16 consecutive patients with CLM treated from 1991 through 2015. Patient demographic data, tumor size, location, previous treatment, follow-up data, and the presence or absence of recurrence were evaluated.


RESULTS
There were 6 males and 10 females (mean age, 48.6 years; range, 20-78 years). Clinical follow-up revealed local recurrences in 4 patients 1.3 to 72 months after surgical excision. No distant metastases were observed. We reviewed previously published articles and analyzed the clinical findings, pathologic examinations, and treatments.


CONCLUSIONS
Surgical tumor excision with a wide lateral and deep margin is the most appropriate method. Other therapeutic methods such as radio- or chemotherapy provide no significant benefits. We recommend long-term follow-up of patients because recurrence is possible although not common.
From the *Division of Plastic Surgery, Department of Surgery, †Department of Pathology, Taipei Veterans General Hospital; and ‡National Yang-Ming University, Taiwan.
Wen-Chieh
WC
Liao
Yu-Chen
YC
Wang
Hsu
H
Ma
D000328:Adult; D000368:Aged; D005260:Female; D006787:Hospitals, Veterans; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D013624:Taiwan; D016896:Treatment Outcome