TFE3, HSP47, and CREB3 Pathways of the Mammalian Golgi Stress Response.
The capacity of each organelle in eukaryotic cells is tightly regulated in accordance with cellular demands by specific regulatory systems, which are generically termed organelle autoregulation. The Golgi stress response is one of the systems of organelle autoregulation and it augments the capacity of Golgi function if this becomes insufficient (Golgi stress). Recently, several pathways of the mammalian Golgi stress response have been identified, specifically the TFE3, HSP47, and CREB3 pathways. This review summarizes the essential parts of the Golgi stress response from the perspective of the organelle autoregulation.
Department of Molecular Biochemistry, Graduate School of Life Science, University of Hyogo.
Mai
M
Taniguchi
Hiderou
H
Yoshida
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D050958:HSP47 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D013312:Stress, Physiological
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C107941:CREB3 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D050958:HSP47 Heat-Shock Proteins; C494660:SERPINH1 protein, human; C069203:TFE3 protein, human