A versatile platform for surface modification of microfluidic droplets.
To advance emulsion droplet technology, we synthesize functional derivatives of Pluronic F127 that can simultaneously act as surfactants and as reactive sites for droplet surface decoration. The amine-, carboxyl-, N-hydroxysuccinimide ester-, maleimide- and biotin-terminated Pluronic F127 allows ligand immobilization on single-emulsion or double-emulsion droplets via electrostatic adsorption, covalent conjugation or site-specific avidin-biotin interaction.
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. kam.leong@columbia.edu.
Mingqiang
M
Li
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. kam.leong@columbia.edu.
Weiqian
W
Jiang
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. kam.leong@columbia.edu.
Zaozao
Z
Chen
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. kam.leong@columbia.edu.
Smruthi
S
Suryaprakash
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Shixian
S
Lv
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
Zhaohui
Z
Tang
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
Xuesi
X
Chen
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. kam.leong@columbia.edu.
Kam W
0000-0002-8133-4955
KW
Leong
D001360:Avidin; D001710:Biotin; D002460:Cell Line; D004655:Emulsions / Q000737:chemistry*; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D020442:Poloxamer / Q000737:chemistry; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*
D004655:Emulsions; D013501:Surface-Active Agents; D020442:Poloxamer; D001360:Avidin; D001710:Biotin