Parallel basal ganglia circuits for decision making.
The basal ganglia control body movements, mainly, based on their values. Critical for this mechanism is dopamine neurons, which sends unpredicted value signals, mainly, to the striatum. This mechanism enables animals to change their behaviors flexibly, eventually choosing a valuable behavior. However, this may not be the best behavior, because the flexible choice is focused on recent, and, therefore, limited, experiences (i.e., short-term memories). Our old and recent studies suggest that the basal ganglia contain separate circuits that process value signals in a completely different manner. They are insensitive to recent changes in value, yet gradually accumulate the value of each behavior (i.e., movement or object choice). These stable circuits eventually encode values of many behaviors and then retain the value signals for a long time (i.e., long-term memories). They are innervated by a separate group of dopamine neurons that retain value signals, even when no reward is predicted. Importantly, the stable circuits can control motor behaviors (e.g., hand or eye) quickly and precisely, which allows animals to automatically acquire valuable outcomes based on historical life experiences. These behaviors would be called 'skills', which are crucial for survival. The stable circuits are localized in the posterior part of the basal ganglia, separately from the flexible circuits located in the anterior part. To summarize, the flexible and stable circuits in the basal ganglia, working together but independently, enable animals (and humans) to reach valuable goals in various contexts.
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. oh@lsr.nei.nih.gov.|National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. oh@lsr.nei.nih.gov.
Okihide
O
Hikosaka
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Ali
A
Ghazizadeh
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Whitney
W
Griggs
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Hidetoshi
H
Amita
D000818:Animals; D001288:Attention / Q000502:physiology; D001479:Basal Ganglia / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D057567:Memory, Long-Term / Q000502:physiology*; D009434:Neural Pathways; D011323:Primates; D011597:Psychomotor Performance / Q000502:physiology*
Attention; Dopamine; Hand movement; Long-term memory; Saccade; Skill