Are gastric hyperplastic polyps an additional manifestation in celiac disease?: Results from a retrospective study.
Gastric polyps are frequently reported in patients undergoing upper endoscopic procedures. In this retrospective study, the association between hyperplastic polyps and celiac disease in Northern Sardinia was estimated.Age, gender, body mass index, and medications taken in the 2 preceding months, including proton-pump inhibitors (PPIs), H2 receptor blockers (anti-H2), Helicobacter pylori status, endoscopic findings, and histology from charts of patients undergoing esophago-gastro-duodenoscopy were reviewed. Polyps were classified as hyperplastic, fundic gland, inflammatory, and adenomatous.3.7% (423/11379) patients had celiac disease. Prevalence of gastric polyps was 4.2% (3.8% among celiac vs 4.2% nonceliac patients). Inflammatory polyp was the most common histotype (55.8% and 56.2%) followed by fundic gland polyps (31.4% and 43.7%), hyperplastic (8.7% and 0%), and adenomas, in celiac and nonceliac patients, respectively. Fundic gland polyps were more common in PPI users (odds ratio: 4.06) than in nonusers (2.65, P = 0.001) among celiac and nonceliac patients. Age older than 50, female gender, esophago-gastro-duodenoscopy year, and PPI use were associated with the presence of polyps, whereas active H pylori infection was not.Gastric polyps were common in Sardinian patients undergoing esophago-gastro-duodenoscopy. However, the previously reported association between hyperplastic polyps and celiac disease was not confirmed in our study.
Dipartimento di Medicina Clinica e Sperimentale, Clinica Medica, Viale San Pietro, Sassari, University of Sassari, Italy Baylor College of Medicine, Michael E. DeBakey, Houston, TX Dipartimento di Medicina, Sezione di Gastroenterologia, Piazza Lucio Severi, San Sisto (Perugia), University of Perugia, Italy.
Maria Pina
MP
Dore
Giovanni Mario
GM
Pes
Chiara
C
Rocchi
Maria Francesca
MF
Loria
Sara
S
Soro
Gabrio
G
Bassotti
D018256:Adenomatous Polyps / Q000453:epidemiology* / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002446:Celiac Disease / Q000453:epidemiology*; D016145:Endoscopy, Digestive System; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D016481:Helicobacter Infections / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000473:pathology*
D005765:Gastrointestinal Agents