Oropouche Virus: Clinical, Epidemiological, and Molecular Aspects of a Neglected Orthobunyavirus.
AbstractOropouche virus (OROV) is an important cause of arboviral illness in Latin American countries, more specifically in the Amazon region of Brazil, Venezuela and Peru, as well as in other countries such as Panama. In the past decades, the clinical, epidemiological, pathological, and molecular aspects of OROV have been published and provide the basis for a better understanding of this important human pathogen. Here, we describe the milestones in a comprehensive review of OROV epidemiology, pathogenesis, and molecular biology, including a description of the first isolation of the virus, the outbreaks during the past six decades, clinical aspects of OROV infection, diagnostic methods, genome and genetic traits, evolution, and viral dispersal.
Evandro Chagas Institute, Ministry of Health, Pará, Brazil.
Jorge Fernando
JF
Travassos da Rosa
MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland.|Virology Research Center, School of Medicine of Ribeirao Preto of University of São Paulo, São Paulo, Brazil.
William Marciel
WM
de Souza
Evandro Chagas Institute, Ministry of Health, Pará, Brazil.
Francisco de Paula
FP
Pinheiro
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Mário Luiz
ML
Figueiredo
Evandro Chagas Institute, Ministry of Health, Pará, Brazil.
Jedson Ferreira
JF
Cardoso
Universidade Federal da Fronteira Sul, Passo Fundo, Rio Grande do Sul, Brazil.
Gustavo Olszanski
GO
Acrani
Evandro Chagas Institute, Ministry of Health, Pará, Brazil.|Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas.
Márcio Roberto Teixeira
MRT
Nunes
D000818:Animals; D001717:Birds / Q000821:virology; D001938:Brazil / Q000453:epidemiology; D002044:Bunyaviridae Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000635:transmission; D002519:Ceratopogonidae / Q000821:virology; D002874:Chromosome Mapping; D003465:Culex / Q000821:virology; D004196:Disease Outbreaks; D004199:Disease Vectors; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D016851:Orthobunyavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010176:Panama / Q000453:epidemiology; D010568:Peru / Q000453:epidemiology; D012896:Sloths / Q000821:virology; D014687:Venezuela / Q000453:epidemiology