Increased Mean Platelet Volume is Associated with Higher In-Hospital Mortality Rate in Patients with Acute Myocardial Infarction.
BACKGROUND
To evaluate the prognostic value of mean platelet volume (MPV) on admission for the in-hospital mortality in patients with acute myocardial infarction (AMI).


METHODS
Medical records of 567 AMI patients were retrospectively reviewed, and their baseline clinical and laboratory characteristics were extracted. The relationships between the MPV and both clinical and laboratory characteristics were analyzed. The predictive value of the MPV for in-hospital death was estimated using receiver operating characteristic (ROC) curve analysis and a multivariate logistic regression model.


RESULTS
The area under the curve (AUC) of MPV for in-hospital death was 0.77 (95% CI: 0.72 - 0.82). At a threshold of 12.5 fL, the sensitivity and specificity of MPV for in-hospital death were 0.58 (95% confidence interval (CI): 0.48 - 0.67) and 0.88 (95% CI: 0.84 - 0.91), respectively. In a multivariable logistic regression model, MPV > 12.5 fL was an independent risk factor for in-hospital mortality, with an odds ratio (OR) of 5.35 (95% CI, 3.03 - 9.45).


CONCLUSIONS
Increased MPV is associated with higher in-hospital mortality rate in patients with AMI.
Xiaoxiao
X
Liu
Shuya
S
Wang
Ling
L
Yuan
Fang
F
Chen
Lizhu
L
Zhang
Xinhe
X
Ye
Zhijun
Z
Han
Chengjian
C
Yang
D019540:Area Under Curve; D016009:Chi-Square Distribution; D057286:Electronic Health Records; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D063847:Mean Platelet Volume; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D016017:Odds Ratio; D010343:Patient Admission; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors