HLA DRB1*03 as a possible common etiology of schizophrenia, Graves' disease, and type 2 diabetes.
BACKGROUND
Autoimmune diseases and schizophrenia share many common features. Association studies confirm a shared genetic association in the human leukocyte antigen (HLA) region between schizophrenia and most autoimmune diseases. To our knowledge, the simultaneous syndromes of Graves' disease (GD) and type 2 diabetes (T2D) in schizophrenia are rare in Tunisia.


METHODS
We report a case of a 42-year-old woman admitted to the department of psychiatry for an acute relapse of chronic schizophrenia. Her medical history revealed that she was followed for Graves' disease and for a type 2 diabetes mellitus. A low-resolution HLA typing was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) techniques according to determine the patient's haplotype.


CONCLUSIONS
Our study suggests that the HLA DRB1*03 allele may explain a common etiology underlying the co-morbidity of Graves' disease, type 2 diabetes, and schizophrenia in our patient.
Laboratoire de Biologie Moléculaire, Service d'Hématologie., Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.|Faculté des Sciences de Tunis, Université Tunis el Manar, 2092 Tunis, Tunisia.
Aicha
A
Sayeh
Service de Psychiatrie, Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.|Faculté de Médecine de Tunis, Université de Tunis El Manar, 1007 Tunis, Tunisia.
Cheker
C
Ben Cheikh
Faculté de Médecine de Tunis, Université de Tunis El Manar, 1007 Tunis, Tunisia.|Service Oto-rhino-laryngologie, Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.
Ali
A
Mardessi
Laboratoire de Biologie Moléculaire, Service d'Hématologie., Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.|Faculté des Sciences de Tunis, Université Tunis el Manar, 2092 Tunis, Tunisia.
Meriem
M
Mrad
Laboratoire de Biologie Moléculaire, Service d'Hématologie., Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.
Brahim
B
Nsiri
Service de Psychiatrie, Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.|Faculté de Médecine de Tunis, Université de Tunis El Manar, 1007 Tunis, Tunisia.
Abdelaziz
A
Oumaya
Laboratoire de Biologie Moléculaire, Service d'Hématologie., Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.|Académie Militaire Fondouk Jédid, 8012 Nabeul, Tunisia.
Najiba
N
Fekih-Mrissa
Autoimmunity; Graves’ disease; HLA; Schizophrenia; Type 2 diabetes