Efficacy of repeated low-dose bevacizumab treatment with long-dosing interval for radiation-induced brain necrosis: A case report.
A 40-year-old Chinese female patient, with radiation-induced brain necrosis after radiosurgery, was treated 6 times with a single dose of 200 mg (3.27 mg/kg) bevacizumab each time, and with an interval of 12-16 weeks between each treatment. Neurological symptoms such as dizziness, fatigue, and headache disappeared after each administration of bevacizumab. The results suggest that repeated bevacizumab treatment using a low-dose and long-dosing interval may significantly alleviate radiation necrosis and its symptoms.
a Department of Radiation Oncology , Affiliated Hospital of Academy of Military Medical Sciences , Beijing , China.
Xiangying
X
Meng
b Radiotherapy Department , Navy General Hospital , Beijing , China.
Rugang
R
Zhao
a Department of Radiation Oncology , Affiliated Hospital of Academy of Military Medical Sciences , Beijing , China.
Shikai
S
Wu
a Department of Radiation Oncology , Affiliated Hospital of Academy of Military Medical Sciences , Beijing , China.
Ge
G
Shen
a Department of Radiation Oncology , Affiliated Hospital of Academy of Military Medical Sciences , Beijing , China.
Lijuan
L
Ding
a Department of Radiation Oncology , Affiliated Hospital of Academy of Military Medical Sciences , Beijing , China.
Bing
B
Sun
a Department of Radiation Oncology , Affiliated Hospital of Academy of Military Medical Sciences , Beijing , China.
Junliang
J
Wang
D000328:Adult; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000068258:Bevacizumab / Q000008:administration & dosage*; D001921:Brain / Q000473:pathology* / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D009336:Necrosis; D011832:Radiation Injuries / Q000139:chemically induced* / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab
Bevacizumab; breast carcinoma; metastasisradiation-induced brain necrosis