[Clinical trials in pulmonary arterial hypertension: a glimpse of history].
Clinical trials have remarkably changed the natural history of pulmonary arterial hypertension (PAH). Despite the relevant progresses achieved in terms of prognosis, PAH is still burned by high mortality rates, disability and low levels of quality of life. The aim of this review is to look over the history of clinical trials in PAH, starting from the little studies with prostacyclin analogues to the recent large randomized placebo-controlled trials. Moreover, the future perspectives of PAH management are addressed.
IRCCS Fondazione SDN, Napoli.
Alberto Maria
AM
Marra
Dipartimento di Cardiologia, Seconda Università degli Studi, A.O.R.N. Monaldi, Napoli.
Michele
M
D'Alto
Dipartimento di Malattie dell'Apparato Respiratorio, Università degli Studi "Federico II", Napoli.
Anna Agnese
AA
Stanziola
Dipartimento di Scienze Mediche Traslazionali, Università degli Studi "Federico II", Napoli - Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università degli Studi "Federico II", Napoli.
Antonio
A
Cittadini
Dipartimento Medico-Chirurgico di Cardiologia, A.O.U. Scuola Medica Salernitana, Salerno.
Eduardo
E
Bossone
D002986:Clinical Trials as Topic; D015195:Drug Design; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D044062:Prostaglandins I / Q000627:therapeutic use; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic
D044062:Prostaglandins I