Primary anorectal mucosal melanoma detected by anorectal cytology.
The detection of primary anorectal melanoma on anal cytology is a rare and challenging diagnosis. We report a case where anorectal cytology showed isolated malignant cells with oval nuclei, prominent nucleoli, and elongated wispy cytoplasmic projections. There was no evidence of squamous dysplasia or melanin pigment identified. To the best of our knowledge, this is the first reported case of a primary anorectal melanoma detected in anorectal cytology. Detection of malignancies other than squamous cell carcinoma can be seen on anorectal cytology and should be considered when there is no evidence of anal intraepithelial neoplasia. Diagn. Cytopathol. 2017;45:452-455. © 2017 Wiley Periodicals, Inc.
Department of Pathology, New York University School of Medicine, New York, New York.
Ryan Paul
http://orcid.org/0000-0003-2155-0346
RP
Lau
Department of Pathology, New York University School of Medicine, New York, New York.
Jeanine
J
Chiaffarano
Department of Pathology, New York University School of Medicine, New York, New York.
Melissa
M
Alexander
Department of Pathology, New York University School of Medicine, New York, New York.
Jolene
J
Octavius
Department of Pathology, New York University School of Medicine, New York, New York.
Omar
O
Azar
Department of Pathology, New York University School of Medicine, New York, New York.
Yan
Y
Shi
Department of Pathology, New York University School of Medicine, New York, New York.
Melissa
M
Yee-Chang
D000368:Aged; D001003:Anal Canal / Q000473:pathology; D001005:Anus Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics*; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen / Q000235:genetics; D008297:Male; D008545:Melanoma / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D009418:S100 Proteins / Q000235:genetics
D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; D009418:S100 Proteins
anal melanoma; anorectal pap test; mucosal melanoma; pap smear