Incidence trends for potentially human papillomavirus-related and -unrelated head and neck cancers in France using population-based cancer registries data: 1980-2012.
Human papillomavirus (HPV) has been recently recognised as a carcinogenic factor for a subset of head and neck cancers (HNC). In Europe, France has one of the highest incidence rates of HNC. The aim of this study is to explore changes in HNC incidence in France, potentially in relation with infection by HPV. HNC were classified into two anatomical groups: potentially HPV-related and HPV-unrelated. Trends over the period 1980-2012 were analysed by an age-period-cohort model based on data from eleven French cancer registries. Among men, the age-standardised incidence rate (ASR) of HNC decreased in both groups, but less so for HPV-related sites as compared to unrelated sites, especially in recent years (annual percentage change [APC] over the period 2005-2012: -3.5% vs. -5.4%). Among women, the ASR increased in both groups, but more rapidly for HPV-related as compared to unrelated sites (APC over the period 2005-2012: +1.9% vs. -0.4%). This preferential growth of HPV-related versus unrelated HNC was observed in the cohorts born from 1930 to 1935. The differences in trends between possible HPV-related and HPV-unrelated sites suggest an increasing incidence of HNC due to HPV infection. The difference was less marked in men as compared to women, most likely because of a higher contamination in the HPV-related group by cancers due to tobacco or alcohol consumption. The pattern observed is consistent with observations made in other countries, with studies of HPV prevalence in HNC and the evolution of sexual behaviour in France.
Registre Général des Cancers de Lille et de sa Région, Centre de Référence Régional en Cancérologie, CHRU de LILLE, Hôpital Calmette - Pavillon Breton, Boulevard du Professeur Jules Leclercq, LILLE cedex, 59037, France.
Karine
0000-0001-8392-3908
K
Jéhannin-Ligier
Centre Hospitalier Lyon Sud, Service de biostatistiques des Hospices civils de Lyon, Pierre Benite, France.|Université de Lyon, Lyon, France.|Université de Lyon 1, Villeurbanne, France.|Cancer Survival Group, Faculty of Epidemiology and Population Health, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Aurélien
A
Belot
Registre Général des Tumeurs du Calvados, U1086 INSERM, UCBN, Centre François Baclesse, Caen, France.
Anne-Valérie
AV
Guizard
Centre Hospitalier Lyon Sud, Service de biostatistiques des Hospices civils de Lyon, Pierre Benite, France.|Université de Lyon, Lyon, France.|Université de Lyon 1, Villeurbanne, France.|Equipe Biostatistique-Santé, CNRS UMR 5558, Laboratoire de Biométrie et de Biologie Evolutive, Villeurbanne, France.
Nadine
N
Bossard
U1086 Inserm, UCBN, UFR médecine Caen, Pôle de Recherche CHRU de Caen, Centre François Baclesse, Caen, France.
Guy
G
Launoy
Centre Hospitalier Lyon Sud, Service de biostatistiques des Hospices civils de Lyon, Pierre Benite, France.|Département des maladies non transmissibles et des traumatismes, Santé Publique France, Saint-Maurice, France.
Zoé
Z
Uhry
Francim Network: Simona Bara, Registre des cancers de la Manche; Marc Colonna, Registre du cancer de l'Isère; Pascale Grosclaude, Registre des cancers du Tarn; Bénédicte Lapôtre-Ledoux, Registre du cancer de la Somme; Emilie Marrer, Registre des cancers du Haut-Rhin; Florence Molinié, Registre des tumeurs de Loire-Atlantique et Vendée; Brigitte Trétarre, Registre des tumeurs de l'Hérault; Michel Velten, Registre des cancers du Bas-Rhin; Anne-Sophie Woronoff, Registre des tumeurs du Doubs et du Territoire de Belfort.
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D005260:Female; D005602:France / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification* / Q000472:pathogenicity; D012042:Registries; D012727:Sex Characteristics
France; cancer registry; epidemiology; head and neck cancer; human papillomavirus; incidence