Mitochondrial Cardiomyopathy with a Unique99mTc-MIBI/123I-BMIPP Mismatch Pattern.
A 42-year-old man was referred to our hospital due to chest pain, diabetes mellitus, and sensorineural hearing loss. Transthoracic echocardiography revealed diffuse left ventricular hypokinesis. He was diagnosed with mitochondrial disease and a c.A3243G mutation was identified in his mitochondrial DNA. This case of mitochondrial cardiomyopathy demonstrated a low uptake of123I-BMIPP, while the uptake of99mTc-MIBI was preserved. In contrast, previous reports have noted the increased uptake of123I-BMIPP and the decreased uptake of99mTc-MIBI. This is the first study to show this unique99mTc-MIBI/123I-BMIPP mismatch pattern. We also discuss the relationships among the cardiac scintigraphy, cardiac magnetic resonance imaging, and histopathology findings.
Division of Cardiology, Sendai Medical Center, National Hospital Organization, Japan.
Ryosuke
R
Tashiro
Noriko
N
Onoue
Hiroya
H
Rikimaru
Kenichi
K
Tsukita
Hiroshi
H
Fujita
Nobuhiro
N
Yamaguchi
Takeshi
T
Ishizuka
Yasushi
Y
Suzuki
Hiroyoshi
H
Suzuki
Tsuyoshi
T
Shinozaki
D000328:Adult; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004452:Echocardiography; D005227:Fatty Acids; D006801:Humans; D007462:Iodobenzenes; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D017237:Mitochondrial Encephalomyopathies / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
D005227:Fatty Acids; D007462:Iodobenzenes; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; D017256:Technetium Tc 99m Sestamibi