Hypofractionated Palliative Radiotherapy with Concurrent Radiosensitizing Chemotherapy for Advanced Head and Neck Cancer Using the "QUAD-SHOT Regimen".
To analyze the outcomes using the hypofractionated palliative radiotherapy regimen "QUAD-Shot" with concurrent radiosensitizing chemotherapy for advanced head and neck cancer.



We analyzed twenty-one patients with newly-diagnosed or recurrent head and neck cancer treated with palliative hypofractionated concurrent chemoradiation using the QUAD-Shot regimen.



All patients received at least one cycle of RT, with sixteen patients (76%) completing all three cycles. 85.7 % of patients had objective response to therapy with five patients (23.8%) demonstrating complete response (CR) and thirteen patients (61.9%) demonstrating partial response (PR). Palliation of symptoms was achieved in all (100%) of the sixteen patients that completed the three cycles. Median overall survival and median progression-free survival were 7 and 4 months, respectively.



QUAD-Shot palliative radiation therapy coupled with radiosensitizing chemotherapy is efficacious and well-tolerated in patients with newly-diagnosed or recurrent head and neck cancer not amenable to curative therapy.
Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, U.S.A. Gamez.mauricio@mayo.edu.
Mauricio E
ME
Gamez
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, U.S.A.
Manuj
M
Agarwal
Department of Radiation Oncology, New York University, New York, NY, U.S.A.
Kenneth S
KS
Hu
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, U.S.A.
John N
JN
Lukens
Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, U.S.A.
Louis B
LB
Harrison
D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D010166:Palliative Care / Q000379:methods*; D011379:Prognosis; D016016:Proportional Hazards Models; D000069473:Radiation Dose Hypofractionation; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D012189:Retrospective Studies
D011838:Radiation-Sensitizing Agents
Quad-Shot; head and neck; palliative; radiosensitizing chemotherapy