Lipid profiles of donors and recipients of liver transplant: like father like son.
OBJECTIVE
Dyslipidemia is common in liver transplant recipients. This retrospective study investigates whether donors play a role.


METHODS
Prospectively collected data of donors and recipients of deceased-donor liver transplantation (DDLT) and living-donor liver transplantation (LDLT) were reviewed. Total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein (HDL) and fasting glucose were compared between groups. HDL ≥1.6 mmol/L at 2 years after transplant was considered the marker of a favorable post-transplant lipid profile in recipients. Univariate and multivariate analyses were performed to identify predictive factors for this marker.


RESULTS
There were 85 DDLTs and 80 LDLTs. LDLT donors were younger (30 vs. 50 years, p < 0.001) and lighter (58.2 vs. 63.4 kg, p = 0.008) and had a lower body mass index (21.2 vs. 23.7, p < 0.001). The DDLT group had more fatty grafts (p = 0.001) and longer cold (375 vs. 103.5 min, p < 0.001) and warm (50.5 vs. 46 min, p = 0.034) ischemia. LDLT donors had lower fasting glucose (4.85 vs. 7.21 mmol/L, p < 0.001) and triglyceride (0.87 vs. 1.22 mmol/L, p = 0.016) but higher HDL (1.58 vs. 1.39 mmol/L, p = 0.022). LDLT recipients also had higher HDL at 1 year (1.48 vs. 1.28 mmol/L, p = 0.026) and 2 years (1.43 vs. 1.21 mmol/L, p = 0.008). Fourteen (16.5%) DDLT recipients and 27 (33.8%) LDLT recipients had HDL ≥1.6 mmol/L at 2 years. On multivariate analysis, donor HDL ≥1.6 mmol/L (RR 4.311, 95% CI 1.666-11.158, p = 0.003) and recipient body mass index <24 (RR 2.753, 95% CI 1.064-7.127, p = 0.037) were the two independent predictive factors.


CONCLUSIONS
LDLT recipients had better lipid profiles than DDLT recipients. The feature of high HDL level in donors was transferred to recipients.
Department of Surgery, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong, China.
Kevin K W
KKW
Chu
Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China. seechingchan@gmail.com.
See Ching
SC
Chan
Department of Surgery, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong, China.
Sui Ling
SL
Sin
Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China.
Albert C Y
ACY
Chan
Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China.
Kenneth S H
KSH
Chok
Department of Medicine, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China.
Ignatius K P
IKP
Cheng
Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China.
Chung Mau
CM
Lo
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D050171:Dyslipidemias / Q000139:chemically induced / Q000150:complications* / Q000453:epidemiology; D005215:Fasting / Q000097:blood; D005220:Fathers; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000032:analysis*; D016031:Liver Transplantation / Q000706:statistics & numerical data* / Q000639:trends; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D014019:Tissue Donors; D066027:Transplant Recipients; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D007166:Immunosuppressive Agents; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides
Cholesterol; Dyslipidemia; Fasting glucose; Lipoprotein; Liver transplant; Triglyceride