Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.
Recent advances in our understanding of tissue regeneration and the development of efficient approaches to induce and differentiate pluripotent stem cells for cell replacement therapies promise exciting avenues for treating degenerative age-related diseases. However, clinical studies and insights from model organisms have identified major roadblocks that normal aging processes impose on tissue regeneration. These new insights suggest that specific targeting of environmental niche components, including growth factors, ECM, and immune cells, and intrinsic stem cell properties that are affected by aging will be critical for the development of new strategies to improve stem cell function and optimize tissue repair processes.
Paul F. Glenn Center for Biology of Aging Research, Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA.
Joana
J
Neves
Paul F. Glenn Center for Biology of Aging Research, Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA.
Pedro
P
Sousa-Victor
Paul F. Glenn Center for Biology of Aging Research, Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA; Leibniz Institute on Aging - Fritz Lipmann Institute, Jena 07745, Germany. Electronic address: hjasper@buckinstitute.org.
Heinrich
H
Jasper
D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence; D006801:Humans; D044968:Regenerative Medicine; D012060:Rejuvenation / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology