Clinical Implications of Plasma N-acetyl-seryl-aspartyl-lysyl-proline Level in Stable Kidney Transplant Recipients.
BACKGROUND
N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is a natural inhibitor of pluripotent hematopoietic stem cell proliferation and is normally found in human plasma. Because AcSDKP is partially eliminated in urine, accumulation of AcSDKP due to chronic renal failure may cause anemia. However, the status of plasma AcSDKP level in stable kidney transplant recipients is unknown although some recipients develop anemia after kidney transplantation. In this study, we investigated the relationship between plasma AcSDKP-like immunoreactive substance (IS) level and clinical characteristics associated with renal anemia in stable kidney transplant recipients.


METHODS
Forty Japanese kidney transplant recipients who underwent transplantation more than 90 days prior to the study were included. Morning blood samples were collected and plasma AcSDKP-IS levels were measured using an enzyme immunoassay.


RESULTS
A significant correlation was observed between plasma AcSDKP-IS level and creatinine clearance. On the other hand, no significant correlation was observed between plasma AcSDKP-IS level and prolyl oligopeptidase activity, angiotensin II, or erythropoietin level. A significant difference in plasma AcSDKP-IS level was observed between recipients with no renal anemia and those with renal anemia.


CONCLUSIONS
These results suggest that plasma AcSDKP level may depend largely on renal function and suggest a possibility that accumulation of AcSDKP may be partially involved in the pathogenesis of renal anemia in stable kidney transplant recipients.
Yosuke
Y
Suzuki
Fumihiko
F
Katagiri
Fuminori
F
Sato
Kanako
K
Fujioka
Yukie
Y
Sato
Takashi
T
Fujioka
Yuhki
Y
Sato
Hiromitsu
H
Mimata
Hiroki
H
Itoh
D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000209:etiology*; D000804:Angiotensin II / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000378:metabolism*; D004921:Erythropoietin / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D016030:Kidney Transplantation; D008875:Middle Aged; D009842:Oligopeptides / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology*; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D009842:Oligopeptides; D004921:Erythropoietin; D000804:Angiotensin II; D003404:Creatinine; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases; C058504:goralatide