Pre-operative treatments for adenocarcinoma of the lower oesophagus and gastro-oesophageal junction: a review of the current evidence from randomized trials.
Adenocarcinomas of the lower oesophagus and gastro-oesophageal junction are a complex clinico-pathological setting. Multimodality therapy is considered mandatory in most disease presentations. Nevertheless, the most appropriate treatment package has yet to be established. We herein summarize the evidence derived from randomized phase III trials on pre-operative treatments in this oncological scenario.
Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy. pierfrancesco.franco@unito.it.
Pierfrancesco
http://orcid.org/0000-0003-2276-0687
P
Franco
Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy.
Francesca
F
Arcadipane
Department of Surgical Sciences, General Surgery 2U and Liver Transplantation Center, University of Turin, Turin, Italy.
Paolo
P
Strignano
Department of Oncology, Medical Oncology 1, AOU Citta' della Salute e della Scienza, Turin, Italy.
Rosella
R
Spadi
Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy.
Elisabetta
E
Trino
Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy.
Stefania
S
Martini
Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy.
Giuseppe Carlo
GC
Iorio
Department of Oncology, Medical Oncology 1, University of Turin, Turin, Italy.
Maria Antonietta
MA
Satolli
Department of Oncology, Medical Oncology 2, AOU Citta' della Salute e della Scienza, Turin, Italy.
Mario
M
Airoldi
Department of Surgical Sciences, General Surgery 2U and Liver Transplantation Center, University of Turin, Turin, Italy.
Renato
R
Romagnoli
Department of Surgical Sciences, General Surgery 1U, University of Turin, Turin, Italy.
Michele
M
Camandona
Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy.
Umberto
U
Ricardi
D000230:Adenocarcinoma / Q000628:therapy*; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000628:therapy*; D004943:Esophagogastric Junction; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013274:Stomach Neoplasms / Q000628:therapy*
Adenocarcinoma; Gastro-oesophageal junction; Neoadjuvant chemotherapy; Oesophageal cancer; Pre-operative chemo-radiation; Radiotherapy