Age-related alterations in the genetics and genomics of the male germ line.
Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the systemic hormonal milieu, accumulation of environmental toxin exposure, aging germ cells, and accumulation of de novo genetic and genomic abnormalities in germ cells. In this article we review the age-related genetic and genomic changes that occur in the male germ line.
Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Scott Department of Urology, Baylor College of Medicine, Houston, Texas.
Amin S
AS
Herati
Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Boryana H
BH
Zhelyazkova
Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Scott Department of Urology, Baylor College of Medicine, Houston, Texas.
Peter R
PR
Butler
Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Scott Department of Urology, Baylor College of Medicine, Houston, Texas; Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas. Electronic address: dlamb@bcm.edu.
Dolores J
DJ
Lamb
D000367:Age Factors; D000375:Aging / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D004249:DNA Damage; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D023281:Genomics; D040941:Heredity; D006801:Humans; D008297:Male; D009154:Mutation; D010331:Paternal Age; D010375:Pedigree; D017382:Reactive Oxygen Species / Q000378:metabolism; D018570:Risk Assessment; D012307:Risk Factors; D013094:Spermatozoa / Q000378:metabolism / Q000473:pathology*
D017382:Reactive Oxygen Species
Genetics; humans; male; paternal age; reproduction