LncRNA H19 promotes atherosclerosis by regulating MAPK and NF-kB signaling pathway.
Atherosclerosis is one of the leading causes of mortality in the world, which is a multistep cardiovascular disease promoted by several of risk factors. However, the detailed mechanism of atherosclerosis remained unclear. LncRNAs have been proved to play an important role in various of biological and pathological processes, but the role of lncRNA in atherosclerosis largely remained unidentified.



Blood sample were collected from 42 patients with atherosclerosis and 37 healthy volunteers. The expression of lncRNA H19 was detected by the qRT-PCR assay. Proliferation and apoptosis of HUVEC were also detected after lncRNA H19 was overexpressed. The expression of p38 and p65 were also measured by Western blot.



Compared with the normal healthy people, the expression of H19 was higher in patients with atherosclerosis. After lncRNA H19 was overexpressed in HUVEC, the proliferation ability was increased while apoptosis was suppressed. What's more, p38 and p65 were increased after lncRNA H19 was overexpressed.



LncRNA H19 was highly expressed in atherosclerosis, which could be used as a potential target for treating atherosclerosis.
Department of Cardiology, University-Town Hospital of Chongqing Medical University, Chongqing, China. 274047837@qq.com.
J-X
JX
Pan
D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000378:metabolism*; D016022:Case-Control Studies; D049109:Cell Proliferation; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D020935:MAP Kinase Signaling System; D018345:Mice, Knockout; D016328:NF-kappa B / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000378:metabolism*; D051996:Transcription Factor RelA / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
C094335:H19 long non-coding RNA; D016328:NF-kappa B; C498143:RELA protein, human; D062085:RNA, Long Noncoding; D051996:Transcription Factor RelA; D048051:p38 Mitogen-Activated Protein Kinases