A simple and efficient method for constructing azepino[4,5-b]indole derivatives via acid catalysis.
A new synthetic methodology has been developed to prepare the biologically important azepino[4,5-b]indole derivatives under Brønsted acid catalysis. The notable features of this protocol include its operational simplicity, high reaction yields and environmentally benign and mild reaction conditions.
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100 Shihquan Road, Kaohsiung 80708, Taiwan. jjwang@kmu.edu.tw.
Siva Senthil
SS
Kumar Boominathan
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100 Shihquan Road, Kaohsiung 80708, Taiwan. jjwang@kmu.edu.tw.
Mutra Mohana
MM
Reddy
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100 Shihquan Road, Kaohsiung 80708, Taiwan. jjwang@kmu.edu.tw.
Ruei-Jhih
RJ
Hou
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100 Shihquan Road, Kaohsiung 80708, Taiwan. jjwang@kmu.edu.tw.
Hui-Fen
HF
Chen
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100 Shihquan Road, Kaohsiung 80708, Taiwan. jjwang@kmu.edu.tw and Department of Medical Research, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Rd, Kaohsiung 807, Taiwan.
Jeh-Jeng
http://orcid.org/0000-0002-3148-1885
JJ
Wang
D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
D001381:Azepines; D007211:Indoles; D008698:Mesylates; C012077:trifluoromethanesulfonic acid