Theoretical modeling of a portable x-ray tube based KXRF system to measure lead in bone.
K-shell x-ray fluorescence (KXRF) techniques have been used to identify health effects resulting from exposure to metals for decades, but the equipment is bulky and requires significant maintenance and licensing procedures. A portable x-ray fluorescence (XRF) device was developed to overcome these disadvantages, but introduced a measurement dependency on soft tissue thickness. With recent advances to detector technology, an XRF device utilizing the advantages of both systems should be feasible.



In this study, we used Monte Carlo simulations to test the feasibility of an XRF device with a high-energy x-ray tube and detector operable at room temperature.



We first validated the use of Monte Carlo N-particle transport code (MCNP) for x-ray tube simulations, and found good agreement between experimental and simulated results. Then, we optimized x-ray tube settings and found the detection limit of the high-energy x-ray tube based XRF device for bone lead measurements to be 6.91 µg g-1bone mineral using a cadmium zinc telluride detector.



In conclusion, this study validated the use of MCNP in simulations of x-ray tube physics and XRF applications, and demonstrated the feasibility of a high-energy x-ray tube based XRF for metal exposure assessment.
Purdue University, School of Health and Human Sciences, West Lafayette, IN, United States of America. Harvard University, T.H. Chan School of Public Health, Boston, MA, United States of America.
Aaron J
AJ
Specht
Marc G
MG
Weisskopf
Linda Huiling
LH
Nie
D001842:Bone and Bones / Q000378:metabolism*; D007854:Lead / Q000378:metabolism*; D057230:Limit of Detection; D009010:Monte Carlo Method; D013052:Spectrometry, X-Ray Emission / Q000295:instrumentation*
D007854:Lead