Metabolic changes in normal-appearing white matter in patients with neuromyelitis optica and multiple sclerosis: a comparative magnetic resonance spectroscopy study.
Background Previous studies with a small sample size have not reported metabolic changes in neuromyelitis optica (NMO). Metabolic changes, such as decreased N-acetylaspartate (NAA), are well-established in patients with multiple sclerosis (MS). It remains unknown whether different patterns of metabolic changes occur in NMO and MS. Purpose To investigate the metabolic changes in normal-appearing white matter (NAWM) in NMO, compared with MS patients and healthy controls (HC), and correlate these changes with clinical disability. Material and Methods We recruited 27 patients with NMO, 24 patients with MS, and 24 HC. Each participant underwent chemical shift imaging with a 1H-MR spectroscopy operating in a 1.5 T magnetic resonance imaging (MRI) scanner. The absolute concentrations of NAA, choline (Cho), creatine (Cr) as well as the metabolite ratios of NAA/Cr, Cho/Cr, and NAA/Cho were measured and compared among the groups. The correlations between the metabolic concentrations, disease duration, and clinical disability (Expanded Disability Status Scale, EDSS) were further explored. Results Compared with HC, a mild increase of Cho without significant NAA changes was observed in NMO patients, while both a significant reduction of NAA and an increase of Cho were observed in MS patients. The absolute concentration of NAA and NAA/Cho ratio were significantly decreased in MS patients in a direct comparison with NMO patients. In MS patients, the EDSS was correlated with the NAA/Cr and Cho/Cr ratios. Conclusion A reduction of NAA was not observed in NMO, implying axonal or neuronal damage may be absent in NAWM for NMO, which is different from MS. A mild increase in Cho was observed in NAWM of NMO patients, suggesting that subtle metabolic changes occur in NMO.
1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China.|2 Brain Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China.
Yunyun
Y
Duan
3 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Zheng
Z
Liu
1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China.|2 Brain Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China.
Yaou
Y
Liu
1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China.|2 Brain Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China.
Jing
J
Huang
1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China.|2 Brain Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China.
Zhuoqiong
Z
Ren
1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China.|2 Brain Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China.
Zheng
Z
Sun
3 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Hai
H
Chen
3 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Huiqing
H
Dong
3 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Jing
J
Ye
1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China.|2 Brain Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China.
Kuncheng
K
Li
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism*; D009471:Neuromyelitis Optica / Q000378:metabolism*; D066127:White Matter / Q000378:metabolism*
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
Neuromyelitis optica (NMO); magnetic resonance spectroscopy (MRS); multiple sclerosis (MS); normal appearing white matter (NAWM)