Oxidative Status and DNA Damage Following Analgesic Treatment in Patients with Acute Pancreatitis.
BACKGROUND
This study is designed to investigate the effect of three different analgesics, used to treat pain in AP, on oxidative stress, DNA damage in mononuclear leukocytes, and on oxidative status.


METHODS
This parallel design randomized controlled trial is composed of three treatment arms, intravenous paracetamol, intravenous dexketoprofen, and intravenous tramadol.


RESULTS
A total of 107 patients were diagnosed with acute pancreatitis within the study period in the ED. Seventyseven of them were included in the study; 26 patients for the paracetamol group, 24 patients for the dexketoprofen group, and 27 patients for the tramadol group. The mean age of study subjects was 52.73 ± 15.38 and 66% (n = 51) of them were men. At the beginning of the study (before treatment), mean levels of DNA damage, TOS, and OSI levels were significantly higher and TAS was significantly lower in the acute pancreatitis groups than in the control group. DNA damage and OSI in HAPS-positive patients were found to be significantly greater than HAPS-negative patients (p = 0.046). DNA damage and oxidative stress were compared between the three groups. There were no differences between the groups in terms of DNA damage (p = 0.42) and also for the oxidatif stress parameters (OSI,TAS,TOS had p-values of p = 0.26, p = 0.78, p = 0.35, respectively).


CONCLUSIONS
There is no difference between the effects of paracetamol, dexketoprofen, and tramadol, which are commonly used to manage acute pain in AP, on DNA damage in human T-lymphocytes and on serine parameters of oxidative status.
B
B
Gulen
A
A
Kocyigit
C
C
Eken
M
M
Serinken
O
O
Karcioglu
A
A
Dur
E
E
Kilic
D000082:Acetaminophen / Q000627:therapeutic use*; D000208:Acute Disease; D000700:Analgesics / Q000627:therapeutic use*; D000975:Antioxidants / Q000032:analysis; D004249:DNA Damage; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010195:Pancreatitis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects; D014147:Tramadol / Q000627:therapeutic use*; D014325:Tromethamine / Q000627:therapeutic use*
D000700:Analgesics; D000975:Antioxidants; D014325:Tromethamine; D000082:Acetaminophen; D014147:Tramadol; D007660:Ketoprofen; C118296:dexketoprofen trometamol