Preoperative Platelet-to-Albumin Ratio Predicts Prognosis of Patients with Pancreatic Ductal Adenocarcinoma After Pancreatic Resection.
The aim of this study was to evaluate a novel prognostic value of preoperative platelet-to-albumin ratio (PAR) in patients resected for pancreatic cancer.



A total of 107 patients who underwent pancreatic resection for pancreatic cancer were studied. The patients were divided into two groups as PAR ≥46.4×103or <46.4×103Survival data were analyzed using the log-rank test for univariate analysis and Cox proportional hazards for multivariate analysis.



The PAR was a significant prognostic index on univariate analysis for disease-free survival (DFS) and overall survival (OS). The PAR retained its significance on multivariate analysis for OS (hazard ratio(HR)=2.344, 95% confidence interval(CI)=1.188-4.624, p=0.014) along with tumor differentiation and nodal involvement. PAR was a significant independent prognostic index for poor DFS on multivariate analysis (HR=1.971, 95% CI=1.128-3.444, p=0.017).



The preoperative PAR is a novel significant independent prognostic index for DFS and OS in patients after pancreatic resection with curative intent.
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan shirai@jikei.ac.jp.|Division of Gene Therapy, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Yoshihiro
Y
Shirai
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Hiroaki
H
Shiba
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Koichiro
K
Haruki
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.|Division of Gene Therapy, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Takashi
T
Horiuchi
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.|Division of Gene Therapy, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Nobuhiro
N
Saito
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Yuki
Y
Fujiwara
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Taro
T
Sakamoto
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.|Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Tadashi
T
Uwagawa
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Katsuhiko
K
Yanaga
D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D010179:Pancreas / Q000473:pathology / Q000601:surgery; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D010976:Platelet Count; D057234:Preoperative Period; D011379:Prognosis; D016016:Proportional Hazards Models; D012709:Serum Albumin / Q000378:metabolism
D012709:Serum Albumin
PAR; Platelet to albumin ratio; inflammation; pancreatic cancer; pancreatic resection; prognostic index