Globalization of pediatric transplantation: The risk of tuberculosis or not tuberculosis.
The risk of TB among pediatric SOT recipients increases as the globalization of medical care continues to broaden. Unlike adults, children and especially infants are more susceptible to TB as a complication after transplantation. Little data exist regarding the true incidence of TB and the optimal risk-based management of this very vulnerable population. Here, we highlight the theoretical and practical issues that complicate the management of these patients and pose some questions that should be addressed when managing these patients. More data are needed to provide optimal guidance of the best diagnostic and management practices to this unique population.
Red Cross War Memorial Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
Mignon
M
McCulloch
Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Philana Ling
http://orcid.org/0000-0001-5169-3714
PL
Lin
D002675:Child, Preschool; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D038622:Internationality; D017093:Liver Failure / Q000150:complications; D016031:Liver Transplantation / Q000009:adverse effects; D016377:Organ Transplantation / Q000009:adverse effects*; D012307:Risk Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D035862:Vulnerable Populations
pediatric solid organ transplantation; tuberculosis