A Finer Print Than TADs: PRC1-Mediated Domains.
Polycomb proteins are well-known epigenetic repressors with unexplained roles in chromatin folding. In this issue of Molecular Cell, Kundu et al. (2017) investigate the structures of PRC1-mediated domains in stem cells and probe their changes upon differentiation and in PRC knockouts.
Epigenetic Regulation and Chromatin Architecture, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
Elena
E
Torlai Triglia
Epigenetic Regulation and Chromatin Architecture, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
Tiago
T
Rito
Epigenetic Regulation and Chromatin Architecture, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany. Electronic address: ana.pombo@mdc-berlin.de.
Ana
A
Pombo
D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D063150:Polycomb Repressive Complex 1 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000072417:Protein Domains
D002843:Chromatin; D063150:Polycomb Repressive Complex 1
5C; PRC1-mediated domains; Phc1; Polycomb bodies; Polycomb repressive complex; STORM; chromatin folding; embryonic stem cells; genome architecture; neural progenitors