Progress in Metabolomics Standardisation and its Significance in Future Clinical Laboratory Medicine.
Today, the technology of 'targeted' based metabolomics is pivotal in the clinical analysis workflow as it provides information of metabolic phenotyping (metabotypes) by enhancing our understanding of metabolism of complex diseases, biomarker discovery for disease development, progression, treatment, and drug function and assessment. This review is focused on surveying and providing a gap analysis on metabolic phenotyping with a focus on targeted based metabolomics from an instrumental, technicalpoint-of-viewdiscussing thestate-of-the-artinstrumentation, pre- to post- analytical aspects as well as an overall future necessity for biomarker discovery and future (pre-) clinical routine application.
School of Health and Biomedical Sciences, Discipline of Laboratory Medicine, RMIT University , Victoria, Australia.
Daniel A
DA
Dias
Biocrates Life Sciences AG , Eduard-Bodem-Gasse 8, 6020 Innsbruck, Austria.
Therese
T
Koal
biomarker discovery; clinical chemistry; laboratory medicine; metabolomics; standardization