Stabilizing ability of surfactant on physicochemical properties of drug nanoparticles generated from solid dispersions.
This study was aimed to examine the nanoparticle formation from redispersion of binary and ternary solid dispersions. Binary systems are composed of various ratios of glibenclamide (GBM) and polyvinylpyrrolidone K30 (PVP-K30), whereas a constant amount at 2.5%w/w of a surfactant, sodium lauryl sulfate (SLS) or Gelucire44/14 (GLC), was added to create ternary systems. GBM nanoparticles were collected after the systems were dispersed in water for 15 min. The obtained nanoparticles were characterized for size distribution, crystallinity, thermal behavior, molecular structure, and dissolution properties. The results indicated that GBM nanoparticles could be formed when the drug content of the systems was lower than 30%w/w in binary systems and ternary systems containing SLS. The particle size ranged from 200 to 500 nm in diameter with narrow size distribution. The particle size was increased with increasing drug content in the systems. The obtained nanoparticles were spherical and showed the amorphous state. Furthermore, because of being amorphous form and reduced particle size, the dissolution of the generated nanoparticles was markedly improved compared with the GBM powder. In contrast, all the ternary solid dispersions prepared with GLC anomalously provided the crystalline particles with the size ranging over 5 µm and irregular shape. Interestingly, this was irrelevant to the drug content in the systems. These results indicated the ability of GLC to destabilize the polymer network surrounding the particles during particle precipitation. Therefore, this study suggested that drug content, quantity, and type of surfactant incorporated in solid dispersions drastically affected the physicochemical properties of the precipitated particles.
a Department of Manufacturing Pharmacy, Faculty of Pharmacy , Mahidol University , Bangkok , Thailand.
Thanu
T
Thongnopkoon
a Department of Manufacturing Pharmacy, Faculty of Pharmacy , Mahidol University , Bangkok , Thailand.|b Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy , Mahidol University , Bangkok , Thailand.
Satit
S
Puttipipatkhachorn
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D005905:Glyburide / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*
D004337:Drug Carriers; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D011205:Povidone; D005905:Glyburide
Gelucire44/14; Nanoparticles; glibenclamide; sodium lauryl sulfate; solid dispersion