Early Termination of Randomized Clinical Trials in Orthopaedics.
Randomized controlled clinical trials (RCTs) in orthopaedics, similar to all medical fields, provide the highest level of clinical data and constitute the cornerstone for evidence-based therapeutic advances. Orthopaedic clinical trials face the same challenges as in other medical fields, such as insufficient recruitment, unforeseen adverse events, and futility. In this article, we highlight the reasons for early termination of clinical trials and provide examples of each type.
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
Nicolas
N
Piuzzi
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
Morad
M
Chughtai
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
Anton
A
Khlopas
Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Replacement, Sinai Hospital of Baltimore, Baltimore, Maryland.
Chukwuweike U
CU
Gwam
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
George
G
Muschler
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
Kurt P
KP
Spindler
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
Michael A
MA
Mont
D057239:Early Termination of Clinical Trials / Q000706:statistics & numerical data*; D006801:Humans; D019637:Orthopedic Procedures; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*