Plant-Made Vaccines in the Fight Against Cancer.
Immunotherapies constitute an important trend in developing new cancer treatments, and several promising candidates are under evaluation in clinical trials. Plants have entered the fight against cancer because they constitute low-cost and efficient hosts for biopharmaceutical production that can also serve as oral delivery vehicles. This review is focused on the knowledge gained through the development of anticancer plant-made vaccines reported thus far, and highlights the potential of this technology - its success being reflected in the number of candidates that are close to market. Future prospects for anticancer plant-made vaccines are also identified.
Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Avenida Dr. Manuel Nava 6, San Luis Potosí, 78210, México; Sección de Biotecnología, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona 550, Lomas Segunda Sección, San Luis Potosí, 78210, México.
Alejandra
A
Wong-Arce
Laboratorio de Bioseparaciones, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Avenida Dr. Manuel Nava 6, SLP, 78210, México.
Omar
O
González-Ortega
Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Avenida Dr. Manuel Nava 6, San Luis Potosí, 78210, México; Sección de Biotecnología, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona 550, Lomas Segunda Sección, San Luis Potosí, 78210, México. Electronic address: rosales.s@fcq.uaslp.mx.
Sergio
S
Rosales-Mendoza
D000818:Animals; D019496:Cancer Vaccines; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D030821:Plants, Genetically Modified; D014614:Vaccines, Synthetic
D019496:Cancer Vaccines; D014614:Vaccines, Synthetic
anti-idiotype antibodies; immunotherapies; malignances; parenteral delivery; subunit vaccines; tumor-associated antigen