Effects of paraoxonase, arylesterase, ceruloplasmin, catalase, and myeloperoxidase activities on prognosis in pediatric patients with sepsis.
BACKGROUND
The present study aimed to investigate the levels of paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARE), ceruloplasmin (CLP), myeloperoxidase (MPO), and catalase (CAT) in pediatric sepsis and to explore their effects on the prognosis of sepsis.


METHODS
Patients diagnosed with sepsis (n=33) and healthy controls (n=30) were included. PON, SPON, ARE, CLP, MPO, and CAT activities were measured in the sepsis and control groups. Additionally, the parameters were compared between survivors and non-survivors in the sepsis group. The levels of hemoglobin, white blood cell, platelet, lactate, and C-reactive protein were measured in the blood samples drawn from the patients with sepsis at diagnosis, at the 48th hour, and on day 7. The pediatric risk of mortality and pediatric logistic organ dysfunction scores of the patients were used for the estimation of severity of disease.


RESULTS
Lower ARE (153.24 vs. 264.32U/L; p<0.001), lower CLP (80.58 vs. 97.98U/L; p=0.032), lower MPO (91.24 vs. 116.55U/L; p=0.023), and higher CAT levels (256.5 vs.145.5kU/L; p=0.003) were determined in the sepsis group as compared to the control group. There was no difference between the groups in terms of PON or SPON levels. No difference was determined between the survivors and non-survivors in terms of any of the parameters.


CONCLUSIONS
The present study determined that ARE, CLP, CAT, and MPO levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units. Further studies with larger samples are required to demonstrate the value of these parameters as prognostic biomarkers in pediatric sepsis.
Department of Pediatrics, Pediatric Child CareUnit, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey. Electronic address: ganimeayar@gmail.com.
Ganime
G
Ayar
Department of Pediatrics, Pediatric Child CareUnit, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.
Yasemin Men
YM
Atmaca
Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
Murat
M
Alışık
Department of Biochemistry, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.
Özcan
Ö
Erel
D000293:Adolescent; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002374:Catalase / Q000097:blood*; D002570:Ceruloplasmin / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009195:Peroxidase / Q000097:blood*; D011379:Prognosis; D018805:Sepsis / Q000097:blood / Q000175:diagnosis
D015415:Biomarkers; D002374:Catalase; D009195:Peroxidase; D002570:Ceruloplasmin; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase
Arylesterase; Prognosis; Sepsis