Prevalence and determinants of left ventricular geometric abnormalities in hypertensive patients: A study based on the updated classification system of left ventricular geometry.
OBJECTIVE
This study was to determine whether different risk factors were associated with different type of left ventricular (LV) geometric abnormalities.


METHODS
This retrospective analysis included 2290 hypertensive participants without other cardiovascular disease, valve disease and with ejection fraction ≥50%. The type of LV geometric abnormality was defined on the basis of the new classification system.


RESULTS
LV geometric abnormalities were detected in 1479 subjects (64.6%), wherein concentric LV remodeling is the most common LV geometric abnormality (40.3%). Large waist circumference (WC) and neck circumference (NC) were positively associated with concentric LV remodeling, whereas body mass index (BMI) [odds ratio (OR) 0.89, 95% CI 0.85∼0.92, P ＜ 0.001] and systolic blood pressure (SBP) (OR 0.99, 95% CI 0.98∼0.99, P = 0.018) were inversely associated with concentric abnormalities. SBP and age were positively associated with eccentric dilated LVH, while male was inversely associated with eccentric dilated left ventricular hypertrophy (LVH). Age was the strongest risk factor for eccentric dilated LVH (OR 1.05, 95% CI 1.03∼1.07, P ＜ 0.001). Age, NC, SBP, hyperuricemia, and alcohol use were positively associated with concentric LVH, whereas BMI (OR 0.95, 95% CI 0.90∼0.99, P = 0.033) and male (OR 0.12, 95% CI 0.07∼0.18, P ＜ 0.001) were negatively associated with concentric LVH.


CONCLUSIONS
The prevalence of hypertensive LV geometric abnormality in rural area of Southern China was obvious higher. Compared with eccentric LV geometric abnormalities, there were more risk factors, including large WC and NC, age, NC, SBP, hyperuricemia, alcohol use, BMI and gender, which were associated with concentric LV geometric abnormalities.
Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Tao
T
Sha
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Yu-Qing
YQ
Huang
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
An-Ping
AP
Cai
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Cheng
C
Huang
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Ying
Y
Zhang
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Ji-Yan
JY
Chen
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Ying-Ling
YL
Zhou
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Xue-Ju
XJ
Yu
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China.
Dan
D
Zhou
Community Health Services Center of Liaobu, Dongguan, 523400, Guangdong, China. Electronic address: tangsongtao@cntv.cn.
Song-Tao
ST
Tang
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China. Electronic address: ying-qingfeng@cntv.cn.
Ying-Qing
YQ
Feng
Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510100, Guangdong, China. Electronic address: ningtan@cntv.cn.
Ning
N
Tan
Cardiovascular risk factor; Hypertension; LV remodeling; Left ventricular geometric abnormality