A redox-economical synthesis of trifluoromethylated enamides with the Langlois reagent.
A redox-economical strategy for the synthesis of trifluoromethylated enamides using copper catalysis is reported. The reaction employs the inexpensive Langlois reagent (CF3SO2Na) and takes place without the need of an external oxidant. The trifluoromethylated enamide products can easily be converted into the corresponding ketone, saturated amide or oxazole.
Department of Organic Chemistry Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden. nicklas.selander@su.se.
Hai-Bin
HB
Yang
Department of Organic Chemistry Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden. nicklas.selander@su.se.
Nicklas
http://orcid.org/0000-0002-9085-0476
N
Selander