Prognostic Value of Expression of MicroRNAs in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
BACKGROUND
microRNAs are widely involved in a variety of life processes and considered as potential biomarkers of tumor prognosis. A growing number of studies have documented that miRNAs were associated with outcome in NSCLC patients and can act as a prognostic marker. However, existing studies concerning the relationship between miRNAs and outcome in NSCLC patients were contentious and dispersive. Therefore, a systematic metaanalysis to explore the prognostic value of miRNAs on NSCLC patients is urgently needed.


METHODS
Electronic databases, including PubMed, EMBASE, and Web of Science were searched for all relevant articles. Only articles investigating the survival effect of microRNAs on NSCLC patients were included in this meta-analysis. Hazard ratios (HRs) with 95% confidence interval (CI) were extracted and pooled on overall survival (OS) and progression free survival (PFS)/disease-specific survival (DSS).


RESULTS
28 articles were finally included in the overall meta-analysis. The pooled results revealed that high expression miR-21 (HR = 2.82, 95% CI: 2.10 - 3.79), miR-200c (HR = 2.05, 95% CI: 1.36 - 3.07), and miR-125b (HR = 1.72, 95% CI: 1.30 - 2.28) were negatively associated with survival in NSCLC patients. Conversely, high expression miR-148b (HR = 0.37, 95% CI: 0.19 - 0.70), miR-365 (HR = 0.40, 95% CI: 0.27 - 0.59), miR-124 (HR = 0.29, 95% CI: 0.16 - 0.53), miR-32 (HR = 0.46, 95% CI: 0.33 - 0.65), miR-146a (HR = 0.35, 95% CI: 0.18 - 0.68), and miR-375 (HR = 0.66, 95% CI: 0.45 - 0.96) were significantly associated with better prognosis. Meanwhile, the expression of miR-93 (HR = 1.19, 95% CI: 0.38 - 3.69) and miR-126 (HR = 0.38, 95% CI: 0.12 - 1.16) showed no relationship with NSCLC prognosis.


CONCLUSIONS
Our meta-analysis provided the evidence that miR-21, miR-200c, miR-125b, miR-148b, miR-365, miR-124, miR-32, miR-146a, and miR-375 can act as prognostic biomarkers in NSCLC.
Bingxiang
B
Zhan
Dapeng
D
Lu
Peng
P
Luo
Baolong
B
Wang
D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics*; D025202:Molecular Diagnostic Techniques; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D035683:MicroRNAs