DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments.
Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-effects include impairments of the hypothalamus/pituitary, thyroid and gonads, as well as decreased bone mineral density and metabolic derangements leading to obesity and/or diabetes mellitus. A systematic approach where CCS are screened for endocrine late-effects based on their cancer history and treatment exposures may improve health outcomes by allowing the early diagnosis and treatment of these complications.
Departments of Pediatric Medicine-Division of Endocrinology.|Departments of Epidemiology and Cancer ControlSt Jude Children's Research Hospital, Memphis, Tennessee, USA.
Wassim
W
Chemaitilly
Departments of Epidemiology and Cancer ControlSt Jude Children's Research Hospital, Memphis, Tennessee, USA.|Division of EndocrinologyBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Laurie E
LE
Cohen
D015519:Bone Density / Q000502:physiology; D003920:Diabetes Mellitus / Q000209:etiology*; D004700:Endocrine System Diseases / Q000209:etiology*; D006801:Humans; D008659:Metabolic Diseases / Q000209:etiology*; D009369:Neoplasms / Q000150:complications*; D009765:Obesity / Q000209:etiology*; D017741:Survivors