Importance of Clonal Complex 258 and IncFK2-likePlasmids among a Global Collection of Klebsiella pneumoniae withblaKPC.
This study was designed to determine the global distribution of clonal complex (CC) 258 and IncFIIK2-likeplasmids withblaKPCamong 522 globalKlebsiella pneumoniaecarbapenemase (KPC)-producingK. pneumoniaeisolates. CC258 (i.e., ST258 [clades I and II], ST11, ST340, and ST512) and ST147 were statistically associated with IncFIIK2-likeKPC-containing plasmids and may possess an epidemiological advantage over isolates that harbored non-IncF KPC-harboring plasmids.
Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.|Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada.
Gisele
G
Peirano
AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, USA.
Patricia A
PA
Bradford
International Health Management Associates, Schaumburg, Illinois, USA.
Krystyna M
KM
Kazmierczak
Public Health Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Liang
L
Chen
Public Health Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Barry N
BN
Kreiswirth
Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada johann.pitout@cls.ab.ca.|Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada.|Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.|University of Pretoria, Pretoria, South Africa.
Johann D D
JD
Pitout
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
IncFK plasmids; Klebsiella pneumoniae; ST258