Why standards are useful for predicting doses.
Germovsek and colleagues have recently concluded that a standard approach to modelling pharmacokinetics is not wrong and appears to be at least as useful as other ad hoc methods for describing drug concentrations. There are other advantages of this approach including learning about biology, comparing different studies, detecting errors and rationalizing dose prediction. A standard approach to size and maturation is not a panacea but provides the framework for challenging new ideas and supports a consistent method of dosing in patients of all ages.
Department of Pharmacology & Clinical Pharmacology, University of Auckland, New Zealand.
Nick H G
NH
Holford
Department of Anaesthesiology, University of Auckland, New Zealand.
Brian J
BJ
Anderson
D000367:Age Factors; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations