Mono-Energy Coronary Angiography with a Compact Synchrotron Source.
X-ray coronary angiography is an invaluable tool for the diagnosis of coronary artery disease. However, the use of iodine-based contrast media can be contraindicated for patients who present with chronic renal insufficiency or with severe iodine allergy. These patients could benefit from a reduced contrast agent concentration, possibly achieved through application of a mono-energetic x-ray beam. While large-scale synchrotrons are impractical for daily clinical use, the technology of compact synchrotron sources strongly advanced during the last decade. Here we present a quantitative analysis of the benefits a compact synchrotron source can offer in coronary angiography. Simulated projection data from quasi-mono-energetic and conventional x-ray tube spectra is used for a CNR comparison. Results show that compact synchrotron spectra would allow for a significant reduction of contrast media. Experimentally, we demonstrate the feasibility of coronary angiography at the Munich Compact Light Source, the first commercial installation of a compact synchrotron source.
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Elena
E
Eggl
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.|Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675 München, Germany.
Korbinian
K
Mechlem
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.|Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675 München, Germany.
Eva
E
Braig
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Stephanie
S
Kulpe
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Martin
M
Dierolf
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.|Max-Planck-Institut für Quantenoptik, Hans-Kopfermann-Straße 1, 85748 Garching, Germany.
Benedikt
B
Günther
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Klaus
K
Achterhold
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Julia
J
Herzen
Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Bernhard
B
Gleich
Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675 München, Germany.
Ernst
E
Rummeny
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675 München, Germany.
Peter B
PB
Noёl
Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany.|Munich School of Bioengineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.|Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675 München, Germany.
Franz
F
Pfeiffer
Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675 München, Germany.
Daniela
D
Muenzel
D003198:Computer Simulation; D003287:Contrast Media / Q000737:chemistry; D017023:Coronary Angiography; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D007455:Iodine / Q000737:chemistry; D059629:Signal-To-Noise Ratio; D017356:Synchrotrons
D003287:Contrast Media; D007455:Iodine; D005682:Gadolinium