Evaluation of the Performance of Two Point-of-Care Analyzers for Total Cholesterol, Triglyceride, and High-Density Lipoprotein Cholesterol Analysis.
BACKGROUND
In this study, we evaluated the analytic performance of two POCT devices and compared the results with a central laboratory method.


METHODS
A total of 100 patients were enrolled in this study. LipidPro (Infopia, USA) and LandMark (Infopia, Korea), were used for measuring total cholesterol (TC), triglyceride (TG), and high density lipoprotein cholesterol (HDL-C). Imprecision and linearity were assessed and the results of two POCT analyzers were compared with a central laboratory method.


RESULTS
Imprecision of LipidPro met the National Cholesterol Education Program (NCEP) criteria (mean % CV: TC 2.8%, TG 3.9%, and HDL-C 4.0%). LandMark met the National Cholesterol Education Program (NCEP) imprecision criteria for TC and TG, but not HDL-C (mean % CV: 2.7%, 3.5%, and 4.7%, respectively). Both analyzers showed excellent linearity for TC, TG, and HDL-C in test ranges. Total errors of TC, TG, and HDL-C measured by LipidPro were 6.1%, 8.7%, and 8.1%, respectively, and met the NCEP goals. The total errors of TG and HDL-C measured by LandMark met the NCEP goals; however, the total error of TC analysis did not meet the NCEP goals (total error; TC 11.1%, TG 11.2%, and HDL-C 9.6%).


CONCLUSIONS
LipidPro and LandMark are simple and rapid tests that provide a reliable alternative to conventional laboratory methods. The LipidPro device showed a slightly better analytical performance than LandMark based on the NCEP goals.
Hyunjung
H
Kim
Yeongsic
Y
Kim
Joonhong
J
Park
Hae-Il
HI
Park
Seungok
S
Lee
Myungshin
M
Kim
Yonggoo
Y
Kim
Soyoung
S
Shin
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D019719:Diagnostic Equipment; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019095:Point-of-Care Systems; D056910:Republic of Korea; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol