Mean cerebral blood volume is an effective diagnostic index of recurrent and radiation injury in glioma patients: A meta-analysis of diagnostic test.
We conducted a meta-analysis to evaluate the diagnostic values of mean cerebral blood volume for recurrent and radiation injury in glioma patients. We performed systematic electronic searches for eligible study up to August 8, 2016. Bivariate mixed effects models were used to estimate the combined sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, diagnostic odds ratios and their 95% confidence intervals (CIs). Fifteen studies with a total number of 576 participants were enrolled. The pooled sensitivity and specificity of diagnostic were 0.88 (95%CI: 0.82-0.92) and 0.85 (95%CI: 0.68-0.93). The pooled positive likelihood ratio is 5.73 (95%CI: 2.56-12.81), negative likelihood ratio is 0.15 (95%CI: 0.10-0.22), and the diagnostic odds ratio is 39.34 (95%CI:13.96-110.84). The summary receiver operator characteristic is 0.91 (95%CI: 0.88-0.93). However, the Deek's plot suggested publication bias may exist (t=2.30, P=0.039). Mean cerebral blood volume measurement methods seems to be very sensitive and highly specific to differentiate recurrent and radiation injury in glioma patients. The results should be interpreted with caution because of the potential bias.
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Zhanzhan
Z
Li
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Qin
Q
Zhou
Office of Cancer Prevent and Control, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Yanyan
Y
Li
Office of Cancer Prevent and Control, Hunan Provincial Tumor Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013 China.
Shipeng
S
Yan
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Jun
J
Fu
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Xinqiong
X
Huang
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Liangfang
L
Shen
D000071937:Cerebral Blood Volume; D059248:Chemoradiotherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005910:Glioma / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D012372:ROC Curve; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage
early diagnosis; glioma; mean cerebral blood volume; meta-analysis