Effect of solid lipid's structure on nanostructured lipid carriers encapsulated with sun filter: characterisation, photo-stability and in vitro release.
Three series of solid lipid are formulated in nanostructured lipid carriers (NLC) system, which encapsulated with sun filter to evaluate the effect on the physicochemical properties of the nanocarriers. Production is performed by ultrasonication-homogenisation, analysis by particle size, zeta potential (ZP), transmission electron microscope, Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD). Moreover, the encapsulation efficiency, ultraviolet performance and in vitro release are also investigated. The particle sizes of NLCs are between 185 and 225 nm and the polydispersity index is lower than 0.4, ZP from -56.4 to -78.6 mV, and the particles are spherical and in homogenous shading. All prepared NCLs encapsulated the sun filter and the EE are higher than 73%. DSC analysis revealed α- to β-polymorphic modification existed in the system of fatty alcohol and fatty acid. However, α, β and β'-polymorphic modifications are exist in the system of cetyl palmitate (PC). Compared with conventional emulsion, all NLCs displayed perfect photo-protective property, especially for the alcohol system. The photo-stability studies showed that the all NLCs have the ability to improve the photo-stability of sunscreens. The in vitro release study suggested all three NLCs displayed sustained release profile and they were fit well with Higuchi equation.
a School of Perfume and Aroma Technology, Shanghai Institute of Technology , Shanghai , People's Republic of China.
Ke
K
Wang
a School of Perfume and Aroma Technology, Shanghai Institute of Technology , Shanghai , People's Republic of China.
Qian-Jie
QJ
Zhang
a School of Perfume and Aroma Technology, Shanghai Institute of Technology , Shanghai , People's Republic of China.
Yu-Lian
YL
Miao
b Infinitus (China) Company Limited , Jiangmen , Guangdong , People's Republic of China.
Shao-Qiang
SQ
Luo
b Infinitus (China) Company Limited , Jiangmen , Guangdong , People's Republic of China.
Hong-Cai
HC
Wang
a School of Perfume and Aroma Technology, Shanghai Institute of Technology , Shanghai , People's Republic of China.
Wan-Ping
WP
Zhang
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000737:chemistry; D014961:X-Ray Diffraction
D004337:Drug Carriers; D008055:Lipids; D013473:Sunscreening Agents
Solid lipid’s structure; in vitro release; photo-stability