New terpenoids from Resina Commiphora.
Three new eudesmane sesquiterpenoids, commiphoranes E1-E3 (1-3), a new podocarpane diterpenoid, commiphorane F (4), three new triterpenoids, commiphoranes G1-G3 (5-7), and fourteen known terpenoids (8-21) were isolated from Resina Commiphora. The structures and relative configurations of new compounds were mainly assigned by spectroscopic methods. In particular, the absolute configuration of 3 was clarified by computational methods. Renoprotective effects of all these isolates were evaluated by using an ELISA assay in TGF-β1-induced rat kidney tubular epithelial cells. The present findings add new facets for chemical profiling of plant resins.
Guangdong Pharmaceutical University, Guangzhou 510006, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Lu
L
Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Qi
Q
Luo
Guangdong Pharmaceutical University, Guangzhou 510006, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Li-Zhi
LZ
Cheng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Yong-Ming
YM
Yan
Guangdong Pharmaceutical University, Guangzhou 510006, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: yxcheng@mail.kib.ac.cn.
Yong-Xian
YX
Cheng
Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address: shmwang@sina.com.
Shu-Mei
SM
Wang
D000818:Animals; D002460:Cell Line; D029744:Commiphora / Q000737:chemistry*; D004847:Epithelial Cells / Q000187:drug effects; D005353:Fibronectins / Q000378:metabolism; D007684:Kidney Tubules / Q000166:cytology; D015394:Molecular Structure; D051381:Rats; D012116:Resins, Plant / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification; D053773:Transforming Growth Factor beta1; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
D005353:Fibronectins; D012116:Resins, Plant; D012717:Sesquiterpenes; D013729:Terpenes; D053773:Transforming Growth Factor beta1; D014315:Triterpenes
Burseraceae; Commiphorane F; Commiphoranes E1–E3; Commiphoranes G1–G3; Resina Commiphora