The Interaction betweenGSTT1,GSTM1, andGSTP1Ile105Val Gene Polymorphisms and Environmental Risk Factors in Premalignant Gastric Lesions Risk.
The study investigated the possible influence ofGSTM1,GSTT1, andGSTP1gene polymorphisms as predisposing factors for premalignant gastric lesions as well as their interaction withH. pyloriinfection, gastrotoxic drugs, smoking, and alcohol consumption. In this study, 270 patients with a complet set of gastric biopsies and successfully genotyped were finally included. The GSTM1 gene polymorphism had significant contribution in mild/severe endoscopic lesions (p= 0.01) as well as in premalignant lesions (p= 0.01). TheGSTM1null genotype increased the risk for mucosal defects inH. pylori-negative patients (OR = 2.27, 95% CI: 1.20-4.37) and the risk for premalignant lesions in patients with no alcohol consumption (OR = 2.13, 95% CI: 1.19-3.83). TheGSTT1deleted polymorphism did not significantly increase the risk for premalignant lesions in the absence of gastrotoxic drugs (OR = 1.82, 95% CI: 0.72-4.74). The combinedGSTT1T1andGSTM1null polymorphisms were borderline correlated with an increased risk for premalignant lesions (OR = 1.72, 95% CI: 1.00-2.97). The wild-typeGSTP1Ile/Ile genotype versus the variant genotypes Ile/Val + Val/Val was significantly associated with a decreased risk of gastric atrophy/intestinal metaplasia (OR = 0.60, 95% CI: 0.37-0.98). In conclusion, theGSTM1andGSTT1null genotypes increased the risk for premalignant and endoscopic gastric lesions, modulated byH. pylori, alcohol, or gastrotoxic drug consumption, while the presence of the GSTP1Val allele seemed to reduce the risk for premalignant lesions.
University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
Anca
0000-0003-2115-6576
A
Negovan
University of Medicine and Pharmacy "Iuliu Hațieganu" Cluj-Napoca, 8 Victor Babeş, 400012 Cluj-Napoca, Romania.
Mihaela
0000-0002-4557-5364
M
Iancu
University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
Valeriu
V
Moldovan
Emergency County Hospital, Tirgu Mureș, Gheorghe Marinescu 50, 540136 Mures, Romania.
Simona
S
Mocan
University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania; Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
Claudia
0000-0002-3235-524X
C
Banescu
D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human