Obstetric outcomes of recurrent pregnancy loss patients diagnosed wıth inherited thrombophilia.
BACKGROUND
Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies. The relation between RPL and inherited thrombophilia requires anticoagulant therapy during pregnancy. However the obstetric outcomes have not been well defined in these RPL patients diagnosed with inherited thrombophilia, who have been given anticoagulant therapy.


OBJECTIVE
To investigate the obstetric outcomes in pregnant women with RPL who are given low molecular weight heparin (LMWH) and low-dose aspirin due to diagnosis of inherited thrombophilia.


METHODS
A hundred and eight RPL women were diagnosed with inherited thrombophilia, and 98 women were diagnosed with unexplained RPL. The patients with inherited thrombophilia were given LMWH and low-dose aspirin. Unexplained RPL patients were not given any medicine. The obstetric outcomes of participants were noted.


RESULTS
In thrombophilic group, the live-birth levels were significantly higher [90 (83%) vs 67 (68%) p < 0.05], and the miscarriage levels were significantly lower than that in the control group [14 (13%) vs 27 (28%) p < 0.01]. The number of patients with preeclampsia was significantly higher in the thrombophilic group [16 (15%) vs 6 (6%) p < 0.05]. The number of preterm births was significantly higher than that of the controls [25 (23%) vs 10 (10%) p < 0.05]. The median gestation age of delivery was 35 weeks for thrombophilic patients and 38 weeks for controls (p < 0.05).


CONCLUSIONS
The RPL patients diagnosed with inherited thrombophilia and who were given LMWH with low-dose aspirin had higher live-birth rates and lower miscarriage rates than those in the unexplained RPL patients. Increased risk of preeclampsia is seen in RPL patients with inherited thrombophilia despite thrombophilia prophylaxis.
Department of Obstetrics and Gynecology, Marmara University School of Medicine, İstanbul, Turkey. cihankaradag2000@hotmail.com.
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Karadağ
Department of Obstetrics and Gynecology, Marmara University School of Medicine, İstanbul, Turkey.
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Yoldemir
Department of Obstetrics and Gynecology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey.
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Karadağ
Department of Obstetrics and Gynecology, Trakya University, Edirne, Turkey.
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İnan
Department of Obstetrics and Gynecology, Trakya University, Edirne, Turkey.
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Dolgun
Department of Obstetrics and Gynecology, Marmara University School of Medicine, İstanbul, Turkey.
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Aslanova
D000026:Abortion, Habitual / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000209:etiology* / Q000473:pathology; D011256:Pregnancy Outcome; D019851:Thrombophilia / Q000150:complications* / Q000473:pathology; D055815:Young Adult
Aspirin; Inherited thrombophilia; Low molecular weight heparin; Preeclampsia; Recurrent pregnancy loss