The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome.
A young woman with Li-Fraumeni syndrome (LFS) was referred to our hospital. On examination, multiple flat neoplasms were detected in addition to semi-pedunculated polyps. Restorative proctocolectomy was performed; one submucosal invasive cancer, two mucosal cancers, and several adenomas with high-grade dysplasia were detected. On immunohistochemical staining with p53, every part of all neoplasms, even the small adenomas, showed strong positive staining. Multiple flat neoplasms may be characteristic of patients with LFS and may have a much higher risk of rapid progression to invasive carcinomas than sporadic neoplasms. Thus, careful and frequent colonoscopy surveillance may be needed for patients with LFS.
Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
Tsukasa
T
Yoshida
Masahiro
M
Tajika
Tsutomu
T
Tanaka
Makoto
M
Ishihara
Yutaka
Y
Hirayama
Nobumasa
N
Mizuno
Kazuo
K
Hara
Susumu
S
Hijioka
Hiroshi
H
Imaoka
Nobuhiro
N
Hieda
Nozomi
N
Okuno
Takashi
T
Kinoshita
Vikram
V
Bhatia
Yasuhiro
Y
Shimizu
Yasushi
Y
Yatabe
Kenji
K
Yamao
Yasumasa
Y
Niwa
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D000236:Adenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D000328:Adult; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016864:Li-Fraumeni Syndrome