Diagnostic Accuracy of Interleukin-6, Interleukin-8, and Interleukin-10 for Predicting Bacteremia in Children with Febrile Neutropenia.
Despite improvements in diagnosis and treatment, infections are still a major cause of morbidity and mortality in children with febrile neutropenia. In the majority of febrile episodes, the source of infection cannot be defined. In this study, we aimed to identify the earlier predictors of bacteremia/fungemia and a useful cytokine to identify the source of infection and to discriminate the patients with culture-confirmed bacterial/fungal infection. The most sensitive cytokine was interleukin (IL)-10 and the most specific was IL-8 in predicting culture-confirmed cases. IL-8 had greater sensitivity and specificity in determination of gram-negative bacterial infections with a higher negative predictive value; therefore, IL-8 can be used particularly to rule out gram-negative bacterial infections. IL-6, IL-8, and IL-10 circulating levels were shown to be higher in cases of infection. Further studies are needed to recommend a routine practice for predicting culture-confirmed bacterial infections.
Ege University Faculty of Medicine, Department of Pediatrics, Division of Infectious Disease, İzmir, Turkey.
Zümrüt
Z
Şahbudak Bal
Nihal
N
Karadaş Özdemir
Semra
S
Şen
Deniz
D
Yılmaz Karapınar
Elif
E
Azarsız
Şöhret
Ş
Aydemir
Fadıl
F
Vardar
D016470:Bacteremia / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D064147:Febrile Neutropenia / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D006090:Gram-Negative Bacteria; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male
C508606:CXCL8 protein, human; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10