Investigating the potential of Tamarindus indica pectin-chitosan conjugate for reducing recovery period in TNBS induced colitis.
The present study was aimed at exploiting the wound healing applications and tablet coating potential of Tamarindus indica pectin-chitosan (PCH) conjugate for reducing recovery period from TNBS induced colitis. The PCH (60:40, 3% w/v) solution when spray coated followed by drying at 50°C created hydrophobic surface, that may be due to interaction of pectin with chitosan as evident from temperature ramping rheological investigations. Further, the 15% w/v coating was sufficient to prevent Mesalamine (Ma) release in pH 1.2. The AUC and AUMC of PCH coated tablets were 1.98 and 17.69 fold increased as compared to uncoated tablets. A synergistic therapeutic effect of PCH conjugate with Ma was evident from the colon/body weight ratio, clinical activity and damage score. Overall, the findings suggested PCH and Ma (20mg) reduces the recovery period from 5 to 4days with reduction in dose.
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Sheshank
S
Sethi
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Rajneet Kaur
RK
Khurana
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Sunil
S
Kamboj
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Radhika
R
Sharma
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Akashdeep
A
Singh
Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India. Electronic address: vikas_pbi@rediffmail.com.
Vikas
V
Rana
D000818:Animals; D048271:Chitosan / Q000008:administration & dosage* / Q000737:chemistry; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D010368:Pectins / Q000008:administration & dosage* / Q000737:chemistry; D053147:Plant Exudates / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D013607:Tablets / Q000008:administration & dosage / Q000737:chemistry; D029861:Tamarindus / Q000737:chemistry; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity; D014945:Wound Healing / Q000187:drug effects
D053147:Plant Exudates; D013607:Tablets; D010368:Pectins; D014302:Trinitrobenzenesulfonic Acid; D048271:Chitosan
Bioavailability; Coating; Rheology; Tamarind pectin