Serum Salusin Levels in ST-Segment Elevation Myocardial Infarction.
BACKGROUND
In our study, we aimed to determine the change in levels of salusin-alpha and salusin-beta at admission and after the treatment in patients with STEMI, who have active atherosclerosis.


METHODS
Serum salusin-alpha and beta levels of 50 patients diagnosed with STEMI in the emergency department were measured at admission and on 7th day post-treatment and compared with serum salusin levels of 50 healthy volunteers.


RESULTS
In STEMI patients, salusin-alpha levels were found to be significantly decreased (p < 0.001) and salusinbeta levels were found to be significantly increased (p < 0.001) compared to healthy volunteers in the control group. 7th day post-treatment salusin-alpha levels were found to be lower and salusin-beta levels were found to be at a higher level compared to healthy individuals (p < 0.001). Negative correlation (r = -.322 p = 0.023) was found between salusin-alpha levels and pulse rate. But no significant correlation was found between salusin-beta levels and biochemical parameters.


CONCLUSIONS
The data of this study support the fact that salusin-alpha levels decrease and salusin-beta levels increase in acute cases such as STEMI.
Mustafa
M
Yilmaz
Metin
M
Atescelik
Sukru
S
Ardic
Mehmet C
MC
Goktekin
Mustafa
M
Yildiz
Mehtap
M
Gurger
Mehmet A
MA
Kobat
Nevin
N
Ilhan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000503:physiopathology
D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; C478739:TOR2A protein, human