Effect of various selenium doses on chromium(IV)-induced nephrotoxicity in a male chicken model.
Our study aimed to explore whether Na2SeO3(Se) can alleviate the nephrotoxicity induced by K2Cr2O7[Cr(VI)]. One hundred and five male chickens were randomly divided into seven groups with 15 chickens each group: The 6 experimental groups received K2Cr2O7alone or in combination with 0.31, 0.63, 1.25, 2.50, and 5.00 mg/kg for 42 days, respectively, while control group was treated with equivalent water. Exposure to Cr(VI) significantly increased MDA contents and organ coefficient, whereas decreased T-SOD activities, Ca2+-ATPase activities, mitochondrial membrane potential and GSH contents, and histological studies demonstrated renal damage. Above indicators were restored by Se supplement (0.31, 0.63, and 1.25 mg/kg), in which supplement with 0.63 mg/kg Se developed more effectively than the other two groups; on the contrary, in the groups of Se supplement with 2.50 and 5.00 mg/kg, the above indicators were not ameliorated and even exacerbated. This study demonstrated that Cr(VI) can result in kidney oxidative damage in male chickens, and Se of certain dose has the protective effects against Cr(VI)-induced nephrptoxicity.
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong, Shandong Agricultural University, Tai´an 271018, China.
Huiyu
H
Wan
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong, Shandong Agricultural University, Tai´an 271018, China.
Yiran
Y
Zhu
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong, Shandong Agricultural University, Tai´an 271018, China.
Peng
P
Chen
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong, Shandong Agricultural University, Tai´an 271018, China.
Yang
Y
Wang
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong, Shandong Agricultural University, Tai´an 271018, China.
Pan
P
Hao
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong, Shandong Agricultural University, Tai´an 271018, China.
Ziqiang
Z
Cheng
Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai´an, Shandong 271018, China. Electronic address: liuyongxia666@163.com.
Yongxia
Y
Liu
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong, Shandong Agricultural University, Tai´an 271018, China. Electronic address: Liujz@sdau.edu.cn.
Jianzhu
J
Liu
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002645:Chickens; D002857:Chromium / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D012643:Selenium / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002857:Chromium; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000252:Calcium-Transporting ATPases; D005978:Glutathione; D012643:Selenium
Chickens; Chromium(VI); Kidney; Mitochondrial membrane potential; Oxidative stress; Selenium