Accuracy of FDG-PET/CT in Colorectal Peritoneal Carcinomatosis: Potential Tool for Evaluation of Chemotherapeutic Response.
Neoadjuvant chemotherapy may be administered to patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC) origin. This study evaluated the performance of18fluorodeoxyglucose positron-emission tomography (FDG-PET)/computed tomography (CT) in detection of PC from CRC and correlated the most metabolically active quadrant with the most affected peritoneal area determined during surgery.



This retrospective study compared the performance of FDG-PET/CT for PC diagnosis in 26 patients with CRC with histopathologically-confirmed PC with a control group of 26 patients. An FDG-PET/CT score established for each patient diagnosed with PC was compared with the peritoneal cancer index (PCI) performed during surgery.



The sensitivity and specificity of FDG-PET/CT for PC detection were 85% (22/26) and 88% (23/26), respectively. The most scored quadrant by FDG-PET/CT corresponded to the most scored quadrant at surgery in 77.3%.



FDG-PET/CT may represent a useful tool for evaluating response to neoadjuvant chemotherapy in patients with PC of CRC origin.
Department of Surgery, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium gabriel.liberale@bordet.be.
Gabriel
G
Liberale
Department of Surgery, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Céline
C
Lecocq
Department of Nuclear Medicine, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Camilo
C
Garcia
Department of Nuclear Medicine, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Kristof
K
Muylle
Department of Medical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Angélique
A
Covas
Department of Medical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Amélie
A
Deleporte
Department of Medical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Alain
A
Hendlisz
Department of Surgery, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Fikri
F
Bouazza
Department of Surgery, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Issam
I
El Nakadi
Department of Nuclear Medicine, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Patrick
P
Flamen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D004358:Drug Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D017063:Outcome Assessment, Health Care / Q000379:methods; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D019788:Fluorodeoxyglucose F18
Colorectal cancer; FDG-PET/CT; PCI; complete cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; neoadjuvant chemotherapy; peritoneal cancer index; peritoneal carcinomatosis