Medication-related osteonecrosis of the jaws caused lethal sepsis in an edentulous patient with multiple systemic factors.
Medication-related osteonecrosis of the jaw (MRONJ) is developed even in the patients who are edentulous and treated with short-term bisphosphonate therapy and oral administration. It sometimes causes lethal sepsis in patients who have multiple health problems such as diabetes, cirrhosis, steroid use for interstitial pneumonia, sepsis, and spinal disk herniation.
Department of Pathophysiology-Periodontal Science Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences 2-5-1 Shikata-cho Kita-ku Okayama 700-8525 Japan.
Keisuke
K
Yamashiro
Department of Oral and Maxillofacial Surgery Hiroshima City Hiroshima Citizens Hospital 7-33 Motomachi Naka-ku Hiroshima 730-0011 Japan.
Aki
A
Sato
Department of Oral and Maxillofacial Surgery Hiroshima City Hiroshima Citizens Hospital 7-33 Motomachi Naka-ku Hiroshima 730-0011 Japan.
Fumihiko
F
Okazaki
Department of Oral and Maxillofacial Surgery Hiroshima City Hiroshima Citizens Hospital 7-33 Motomachi Naka-ku Hiroshima 730-0011 Japan.
Makoto
M
Nakano
Department of Oral and Maxillofacial Surgery Hiroshima City Hiroshima Citizens Hospital 7-33 Motomachi Naka-ku Hiroshima 730-0011 Japan.
Koichi
K
Sawaki
Department of Oral and Maxillofacial Surgery Hiroshima City Hiroshima Citizens Hospital 7-33 Motomachi Naka-ku Hiroshima 730-0011 Japan.
Yasuhisa
Y
Hirata
Department of Oral and Maxillofacial Reconstructive Surgery Okayama University Hospital 2-5-1 Shikata-cho Kita-ku Okayama 700-8525 Japan.
Eiki
E
Yamachika
Department of Oral and Maxillofacial Reconstructive Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho Kita-ku Okayama 700-8525 Japan.
Seiji
S
Iida
Department of Pathophysiology-Periodontal Science Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences 2-5-1 Shikata-cho Kita-ku Okayama 700-8525 Japan.
Shogo
S
Takashiba
Antiangiogenic medications; antiresorptive agents; bisphosphonate; bisphosphonate‐related osteonecrosis of the jaw; medication‐related osteonecrosis of the jaw; systemic factors