Evaluation of therapeutic laser influences on the healing of third-degree burns in rats according to different wavelengths.
BACKGROUND
One of the most important innovative methods for tissue repair promotion is therapeutic lasers with photobiomodulution effects. The aim of this study was to investigate the effect of four different wavelengths of therapeutic laser (405, 532, 660 and 810 nm) on healing of third-degree burns from both clinical and pathological standpoints in rats.


METHODS
60 male Wistar rats were used. Animals were anesthetized and dorsal hairs were shaved and third-degree skin burns were created by use of a 95°C copper stamp. Lesions were irradiated with 1.5 J/cm2energy densities and 200 mW/cm2power densities.


RESULTS
Statistical analyses of the "wound contraction" changes between five groups during the study showed more reduction in wound size in all laser groups in comparison with the control group; but these differences were not statistically significant except between red and blue lasers on the last day of experiment.


CONCLUSIONS
Results of our study showed that using therapeutic lasers with green, blue, red, and infrared wavelengths may accelerate healing process. This trend is more obvious in red and infrared groups especially after acute phase, however, this effect was neither statistically nor clinically significant.
a AJA University of Medical Sciences , Tehran , Iran.
Reza
R
Fekrazad
b Private Practice , London , UK.
Alireza
A
Nikkerdar
c Shahid Beheshti University , Tehran , Iran.
Khojasteh
K
Joharchi
c Shahid Beheshti University , Tehran , Iran.
Katayoun Am
KA
Kalhori
c Shahid Beheshti University , Tehran , Iran.
Fatemeh
F
Mashhadi Abbas
d Private Practice , Tehran , Iran.
Fariborz
F
Salimi Vahid
D000818:Animals; D002056:Burns / Q000473:pathology / Q000628:therapy*; D007259:Infrared Rays / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D017319:Photosensitizing Agents / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000502:physiology*
D017319:Photosensitizing Agents
Cosmeceuticals; lasersand light sources; therapeutic laser; topical agents