Preparation, characterization and drug delivery study of a novel nanobiopolymeric multidrug delivery system.
New nanocarrier for codelivery of curcumin and doxorubicin as the anticancer drugs was synthesized using biocompatible and biodegradable materials. Firstly, an inclusion complex of amylose (Am) and curcumin (CUR) was formed through entrapment of curcumin into the amylose helices. Then the surface of amylose-curcumin (Am-CUR) complex was modified by polycaprolactone (PCL) via esterification reaction between hydroxyl functional groups of amylose and carbonyl groups of PCL. Finally, poly citric acid (PCA) reacted with terminal hydroxyl groups of PCL by esterification reaction. Then, doxorubicin (DOX) reacted with the surface carboxylic acid functional groups of Am-CUR-PCL-PCA through noncovalent interactions to form Am-CUR-PCL-PCA-DOX as a multidrug delivery system. These new synthesized nanomaterials were characterized by spectroscopic measurement methods such as IR spectroscopy, UV-vis spectroscopy, NMR spectroscopy, and scanning electron microscopy. FE-SEM analyses and DLS measurements showed that the hydrodynamic dimensions of Am-Cur-PCL-PCA were about 50nm. Due to the presence of ester bonds, the synthesized nanomaterials are pH sensitive. Furthermore, the resulting copolymer was completely water soluble because of the hydrophilic nature of poly citric acid part of copolymer and therefore successfully can be utilized in biomedical applications.
Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran. Electronic address: A_dadkhahtehrani@yahoo.com.
Abbas
A
Dadkhah Tehrani
Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran.
Masoumeh
M
Parsamanesh
D000688:Amylose / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry*; D019343:Citric Acid / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D000067493:Dynamic Light Scattering; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D014961:X-Ray Diffraction
D001704:Biopolymers; D011091:Polyesters; C016240:polycaprolactone; D019343:Citric Acid; D000688:Amylose; D003474:Curcumin
Anticancer; Biopolymer; Drug delivery; Nanocarrier