The effect of genistein on glucose control and insulin sensitivity in postmenopausal women: A meta-analysis.
Preclinical studies have revealed the beneficial effects of genistein in pancreatic β-cell functions. The results of randomized controlled trials (RCTs) in assessing the effects of genistein on glucose metabolism are inconsistent, however. The aim of this meta-analysis is to evaluate the effects of genistein on glucose control and insulin sensitivity in postmenopausal women. This study searched the Medline, PubMed, and Cochrane databases, and ClinicalTrials.gov for trials from January 1970 to February 2016. We included RCTs that investigated the effects of genistein on glucose control and insulin metabolism in postmenopausal women. We also performed pooled analyses with weighted mean difference (WMD) and 95% confidence intervals (CI) according to the RevMan 5.3 software with the random-effects model. Seven eligible RCTs with 670 participants were included in the meta-analysis. Compared with placebos, genistein exhibited significant effects in lowering fasting glucose levels (WMD, -6.35mg/dL [95% CI, -10.78 to -1.93]; P=0.005), fasting insulin concentrations (WMD, -1.92μIU/mL [95% CI, -3.04 to -0.79]; P=0.0008), and HOMA-IR values (WMD, -0.74 [95% CI, -1.21 to -0.28]; P=0.002). Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women. Long-term treatment may have greater effects than short-term use. The role and safety of genistein in glucose control in postmenopausal women require further investigation.
Department of Pharmacy, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Yang
Y
Liu
Department of Pharmacy, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Jiapeng
J
Li
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Tiansheng
T
Wang
Department of Pharmacy, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Yitong
Y
Wang
Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, 56 Nanlishi Road, Xicheng District, Beijing 100045, China. Electronic address: lb.zhao@163.com.
Libo
L
Zhao
Department of Pharmacy, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. Electronic address: phaseistudy@163.com.
Yi
Y
Fang
D001786:Blood Glucose / Q000187:drug effects*; D005215:Fasting; D005260:Female; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000187:drug effects*
D001786:Blood Glucose; D007328:Insulin; D019833:Genistein
Genistein; Glucose metabolism; Insulin sensitivity; Meta-analysis; Postmenopausal