Fabrication of biodegradable Zn-Al-Mg alloy: Mechanical properties, corrosion behavior, cytotoxicity and antibacterial activities.
In this work, binary Zn-0.5Al and ternary Zn-0.5Al-xMg alloys with various Mg contents were investigated as biodegradable materials for implant applications. Compared with Zn-0.5Al (single phase), Zn-0.5Al-xMg alloys consisted of the α-Zn and Mg2(Zn, Al)11with a fine lamellar structure. The results also revealed that ternary Zn-Al-Mg alloys presented higher micro-hardness value, tensile strength and corrosion resistance compared to the binary Zn-Al alloy. In addition, the tensile strength and corrosion resistance increased with increasing the Mg content in ternary alloys. The immersion tests also indicated that the corrosion rates in the following order Zn-0.5Al-0.5Mg<Zn-0.5Al-0.3Mg<Zn-0.5Al-0.1Mg<Zn-0.5Al. The cytotoxicity tests exhibited that the Zn-0.5Al-0.5Mg alloy presents higher viability of MC3T3-E1 cell compared to the Zn-0.5Al alloy, which suggested good biocompatibility. The antibacterial activity result of both Zn-0.5Al and Zn-0.5Al-Mg alloys against Escherichia coli presented some antibacterial activity, while the Zn-0.5Al-0.5Mg significantly prohibited the growth of Escherichia coli. Thus, Zn-0.5Al-0.5Mg alloy with appropriate mechanical properties, low corrosion rate, good biocompatibility and antibacterial activities was believed to be a good candidate as a biodegradable implant material.
Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran. Electronic address: rezabakhsheshi@pmt.iaun.ac.ir.
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Bakhsheshi-Rad
Department of Materials, Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.
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Hamzah
Department of Materials, Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.
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Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
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Kasiri-Asgarani
Department of Materials and Mechanical Engineering, Buein Zahra Technical University, Qazvin 3451745346, Iran.
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Farahany
Department of Microbiology, Faculty of Biological Sciences, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
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Akbari
KISWIRE Sdn. Bhd, Research and Development Centre, Johor, Malaysia.
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D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D003343:Corrosion; D058266:Dielectric Spectroscopy; D004926:Escherichia coli / Q000187:drug effects; D008422:Materials Testing; D051379:Mice; D008826:Microbial Sensitivity Tests; D013052:Spectrometry, X-Ray Emission; D014961:X-Ray Diffraction
D000497:Alloys; D000900:Anti-Bacterial Agents; C000619411:Zn-0.5Al-0.5Mg alloy
Antibacterial activity; Corrosion; Cytotoxicity; Mechanical property; Microstructure; Zinc alloys