Correlation Between Clinicaland Pathological Characteristics of Henoch-Schönlein Purpura Nephritis in Adults.
BACKGROUND
Henoch-Schönlein purpura nephritis (HSPN) mainly affects children and is less common in adults, but its associated pathological changes are severe in adults, in whom it results in a poor prognosis. This study aimed to analyze the clinical and pathological characteristics of HSPN in adults and to identify the correlations among them.


METHODS
Clinical and pathological data from139 patients older than 18 years of age who had been diagnosed with HSPN and had received renal biopsy at our center from January 2012 to November 2014 were collected and were grouped according to the different conditions and analyzed retrospectively.


RESULTS
The 139 HSPN patients included 74 men and 65 women, with an average age of 39.17 ± 15.87 years. The pathological grade was IIIa in most of the patients, and moderate proteinuria was the most common clinical type. Kidney failure and 24-hour total urinary protein, serum uric acid, cystatin C, and β2-microglobulin levels were positively correlated with the pathological grade and activity (P < .05). Age, kidney failure, and uric acid were positively correlated with the pathological chronicity (P < .05).


CONCLUSIONS
The clinical characteristics of the adult HSPN patients were correlated with the severity of the renal pathology. It is feasible to predict renal pathological changes according to the clinical manifestations of adult HSPN patients.
Shan
S
Lu
Dong
D
Liu
Jing
J
Xiao
Genyang
G
Cheng
Xiaoxue
X
Zhang
Zhangsuo
Z
Liu
Department of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. zhanzhengzhao@zzu.edu.cn.
Zhanzheng
Z
Zhao
D000328:Adult; D000367:Age Factors; D001706:Biopsy / Q000379:methods / Q000706:statistics & numerical data; D002681:China / Q000453:epidemiology; D055316:Cystatin C / Q000097:blood; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000453:epidemiology; D007677:Kidney Function Tests / Q000379:methods / Q000706:statistics & numerical data; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D012720:Severity of Illness Index; D013223:Statistics as Topic; D014527:Uric Acid / Q000097:blood
D055316:Cystatin C; D014527:Uric Acid