Effect of Scutellariae herba extracts in experimental model of skin burns: histological and immunohistochemical assessment.
The skin burns are an issue of great interest and seriousness in the public health domain, by their destructive features. Natural medicinal products are extensively used from ancient times, in ethnopharmacology, for the treatment of skin injuries (burns, wounds, ulcerations) due to the local modulation of the cellular response, in terms of emollient, demulcent, astringent, anti-inflammatory, antimicrobial, epithelizing, wound-healing, immunomodulatory and antioxidant effects.


OBJECTIVE
Histological and immunohistochemical assessment of antiseptic, anti-inflammatory, astringent and cicatrizing effects of Scutellariae (altissimae, galericulatae, hastifoliae) herba extracts administered in the form of 20% topical preparations (cold-creams), in experimental model of third degree skin burns, at Wistar rats. Caffeic acid and chlorogenic acid derivatives were identified in all herbal samples. The most active was the cold-cream with 20% Scutellariae hastifoliae herba soft extract, promoting the neoangiogenesis vessels and granulation tissue. Flavonoids, tannins and polyphenol carboxylic acids are the main active principles responsible for antiseptic, anti-inflammatory, astringent and cicatrizing effects of herbal extracts. Beeswax, from the formulation of cold-creams, acts as emollient, epithelizing, cicatrizing and biostimulator.
Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania; ludovic_bejenaru@yahoo.com.
Cornelia
C
Bejenaru
George Dan
GD
Mogoşanu
Ludovic Everard
LE
Bejenaru
Andrei
A
BiŢă
Tudor Adrian
TA
Bălşeanu
Floriana Elvira
FE
Ionică
D000818:Animals; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D007150:Immunohistochemistry; D008962:Models, Theoretical; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D031363:Scutellaria / Q000737:chemistry*; D012867:Skin / Q000473:pathology*
D001688:Biological Products; D010936:Plant Extracts