Development and Validation of a Novel Generic Health-related Quality of Life Instrument With 20 Items (HINT-20).
OBJECTIVE
Few attempts have been made to develop a generic health-related quality of life (HRQoL) instrument and to examine its validity and reliability in Korea. We aimed to do this in our present study.


METHODS
After a literature review of existing generic HRQoL instruments, a focus group discussion, in-depth interviews, and expert consultations, we selected 30 tentative items for a new HRQoL measure. These items were evaluated by assessing their ceiling effects, difficulty, and redundancy in the first survey. To validate the HRQoL instrument that was developed, known-groups validity and convergent/discriminant validity were evaluated and its test-retest reliability was examined in the second survey.


RESULTS
Of the 30 items originally assessed for the HRQoL instrument, four were excluded due to high ceiling effects and six were removed due to redundancy. We ultimately developed a HRQoL instrument with a reduced number of 20 items, known as the Health-related Quality of Life Instrument with 20 items (HINT-20), incorporating physical, mental, social, and positive health dimensions. The results of the HINT-20 for known-groups validity were poorer in women, the elderly, and those with a low income. For convergent/discriminant validity, the correlation coefficients of items (except vitality) in the physical health dimension with the physical component summary of the Short Form 36 version 2 (SF-36v2) were generally higher than the correlations of those items with the mental component summary of the SF-36v2, and vice versa. Regarding test-retest reliability, the intraclass correlation coefficient of the total HINT-20 score was 0.813 (p<0.001).


CONCLUSIONS
A novel generic HRQoL instrument, the HINT-20, was developed for the Korean general population and showed acceptable validity and reliability.
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Min-Woo
MW
Jo
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Hyeon-Jeong
HJ
Lee
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Soo Young
SY
Kim
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Seon-Ha
SH
Kim
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Hyejung
H
Chang
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Jeonghoon
J
Ahn
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Minsu
M
Ock
D000328:Adult; D000368:Aged; D005195:Family Relations; D005260:Female; D006240:Happiness; D006304:Health Status; D006801:Humans; D007182:Income; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010549:Personal Satisfaction; D011788:Quality of Life; D011795:Surveys and Questionnaires; D055815:Young Adult
 Questionnaire;  Validation study; Health-related quality of life