Using Circulating miRNAs as Biomarkers for the Evaluation and Monitoring of the Mitochondrial Damage in the Critically Ill Polytrauma Patients.
BACKGROUND
The multiple-traumatic critical patient presents a variety of pathophysiological, cellular, and molecular dysfunctions. One of the most important is represented by mitochondrial damage which afterwards is responsible for the augmentation and worsening of a series of pathologies that lead to the worsening of the clinical status of the patient. The severe inflammatory response, sepsis, and the redox imbalance are other pathologies that together with the multiple traumas are responsible for the mitochondrial dysfunctions. As an overview, we can say that both the mitochondrial damage as well as the clinical statuses of those patients are responsible for an increase in the chances of multiple organ dysfunction syndrome and death of critical patients with multiple trauma from the Intensive Care Units (ICU). In this paper we wish to summarize the microRNAs that can be used as biomarkers for evaluation and monitoring of the mitochondrial activity in critical patients with multiple traumas.


METHODS
For the paper, literature available in the international databases PubMed and Scopus until the year 2015 has been consulted. The key words used for the article search were "mitochondrial damage", "microRNAs biomarkers", and "critically ill polytrauma patients".


RESULTS
As a result of the research based on the key words presented above, we found 234 papers. From those, after rigorous analysis 64 were selected as being in conformity with the needs of this paper.


CONCLUSIONS
The critical polytrauma patient needs a specific evaluation and monitoring due to the complexity of the dysfunctions that appear at the cellular level. The use of microRNAs as biomarkers for the mitochondrial damage can be of real use for intensive care medicine. Nevertheless, more studies are required in order to determine a larger panel of microRNAs which can have an impact on mitochondrial damage.
Ovidiu H
OH
Bedreag
Marius
M
Papurica
Alexandru F
AF
Rogobete
Dorel
D
Sandesc
Raluca
R
Dumache
Carmen A
CA
Cradigati
Mirela
M
Sarandan
Lavinia M
LM
Bratu
Sonia E
SE
Popovici
Laurentiu V
LV
Sima
D015415:Biomarkers; D000074166:Circulating MicroRNA / Q000032:analysis*; D016638:Critical Illness; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009104:Multiple Trauma / Q000378:metabolism*
D015415:Biomarkers; D000074166:Circulating MicroRNA