A fluorogenic molecular nanoprobe with an engineered internal environment for sensitive and selective detection of biological hydrogen sulfide.
A nanoreactor approach based on the amphiphilic assembly of various molecules offers a chance to finely engineer the internal reaction medium to enable highly selective and sensitive detection of H2S in biological media, being useful for microscopic imaging of cellular processes and in vitro diagnostics with blood samples.
Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr and Department of Chemical & Biological Engineering, Korea University, Seoul 136-713, Korea.
Myung
M
Kim
Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr and Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemungu, Seoul 120-749, Korea.
Young Hun
YH
Seo
Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
Youngsun
Y
Kim
Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
Jeongyun
J
Heo
Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemungu, Seoul 120-749, Korea.
Woo-Dong
WD
Jang
Department of Chemical & Biological Engineering, Korea University, Seoul 136-713, Korea.
Sang Jun
SJ
Sim
Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
Sehoon
http://orcid.org/0000-0002-8074-1006
S
Kim
D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis* / Q000737:chemistry; D008856:Microscopy, Fluorescence; D049329:Nanostructures / Q000737:chemistry*; D009599:Nitroprusside / Q000737:chemistry / Q000378:metabolism; D010078:Oxazines / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
D005456:Fluorescent Dyes; D010078:Oxazines; D013501:Surface-Active Agents; D009599:Nitroprusside; C014180:resorufin; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide