Religiousness, Spirituality, and Salivary Cortisol in Breast Cancer Survivorship: A Pilot Study.
Psychoneuroimmunological theory suggests a physiological relationship exists between stress, psychosocial-behavioral factors, and neuroendocrine-immune outcomes; however, evidence has been limited.



The primary aim of this pilot study was to determine feasibility and acceptability of a salivary cortisol self-collection protocol with a mail-back option for breast cancer survivors. A secondary aim was to examine relationships between religiousness/spirituality (R/S), perceptions of health, and diurnal salivary cortisol (DSC) as a proxy measure for neuroendocrine activity.



This was an observational, cross-sectional study. Participants completed measures of R/S, perceptions of health, demographics, and DSC.



The sample was composed of female breast cancer survivors (n = 41). Self-collection of DSC using a mail-back option was feasible; validity of mailed salivary cortisol biospecimens was established. Positive spiritual beliefs were the only R/S variable associated with the peak cortisol awakening response (rs = 0.34, P = .03). Poorer physical health was inversely associated with positive spiritual experiences and private religious practices. Poorer mental health was inversely associated with spiritual coping and negative spiritual experiences.



Feasibility, validity, and acceptability of self-collected SDC biospecimens with an optional mail-back protocol (at moderate temperatures) were demonstrated. Positive spiritual beliefs were associated with neuroendocrine-mediated peak cortisol awakening response activity; however, additional research is recommended.



Objective measures of DSC sampling that include enough collection time points to assess DSC parameters would increase the rigor of future DSC measurement. Breast cancer survivors may benefit from nursing care that includes spiritual assessment and therapeutic conversations that support positive spiritual beliefs.
Author Affiliations: College of Nursing, University of Utah, Salt Lake City (Dr Hulett); Sinclair School of Nursing (Drs Hulett, Armer, Stewart, McDaniel, and Smith), Ellis Fischel Cancer Center (Drs Armer, Stewart, and Smith), Department of Biostatistics and Research Design Unit, School of Medicine (Dr Leary), and Department of Fisheries and Wildlife, School of Natural Resources (Ms Millspaugh), University of Missouri, Columbia; and Wildlife Biology Program, Department of Ecosystem and Conservation Sciences, University of Montana, Missoula (Dr Millspaugh).
Jennifer M
JM
Hulett
Jane M
JM
Armer
Emily
E
Leary
Bob R
BR
Stewart
Roxanne
R
McDaniel
Kandis
K
Smith
Rami
R
Millspaugh
Joshua
J
Millspaugh
D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000503:physiopathology* / Q000523:psychology*; D000073116:Cancer Survivors / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D008875:Middle Aged; D026441:Mind-Body Therapies; D010865:Pilot Projects; D012067:Religion; D029181:Spirituality; D000073859:Survivorship
D006854:Hydrocortisone