Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers.
Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition. Cancer Discov; 7(2); 131-3. ©2017 AACRSee related article by Olsen et al., p. 202.
Department of Molecular and Medical Genetics, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
Rosalie
R
Sears
Department of Biomedical Engineering, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon. grayjo@ohsu.edu.
Joe W
JW
Gray
D001943:Breast Neoplasms; D002352:Carrier Proteins; D045744:Cell Line, Tumor; D057890:Epigenomics; D058750:Epithelial-Mesenchymal Transition; D020690:GTPase-Activating Proteins; D006801:Humans; D016328:NF-kappa B; D020703:ras GTPase-Activating Proteins
D002352:Carrier Proteins; C462952:DAB2IP protein, human; D020690:GTPase-Activating Proteins; D016328:NF-kappa B; C576391:RASAL2 protein, human; D020703:ras GTPase-Activating Proteins