The Change in Body Weight During Hospitalization Predicts Mortality in Patients With Acute Decompensated Heart Failure.
BACKGROUND
In our experience, the change in body weight (BW) during hospitalization varies greatly in patients with acute decompensated heart failure (HF). Since the clinical significance of a change in BW is not clear, we investigated whether a change in BW could predict mortality.


METHODS
We retrospectively enrolled 130 patients (72 males; aged 68 ± 10 years) who were hospitalized due to acute decompensated HF and followed for 2 years after discharge. The change in the BW index during hospitalization (ΔBWI) was calculated as (BW at hospital admission minus BW at hospital discharge)/body surface area at hospital discharge.


RESULTS
The patients were divided into quartiles according to ΔBWI, and the 2-year mortality rates in the quartiles with the lowest, second, third and highest ΔBWI were 18.8%, 12.1%, 3.1% and 9.1%, respectively. In a multivariate Cox proportional hazards analysis after adjusting for variables with a P value less than 0.05, ΔBWI was independently associated with 2-year mortality (P = 0.0002), and the quartile with the lowest ΔBWI had a higher relative risk (RR) for 2-year mortality than the quartile with the highest ΔBWI (RR: 7.46, 95% confidence interval: 1.03 - 53.99, P = 0.04).


CONCLUSIONS
In conclusion, ΔBWI was significantly associated with 2-year mortality after discharge, which indicates that ΔBWI might be a simple predictor of prognosis in acute decompensated HF.
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan; Department of Laboratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Tomo
T
Komaki
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan; Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of Medicine, Fukuoka, Japan.
Shin-Ichiro
SI
Miura
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Tadaaki
T
Arimura
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Yuhei
Y
Shiga
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Joji
J
Morii
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Takashi
T
Kuwano
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Satoshi
S
Imaizumi
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Ken
K
Kitajima
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Atsushi
A
Iwata
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Natsumi
N
Morito
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Eiji
E
Yahiro
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Kanta
K
Fujimi
Department of Laboratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Akira
A
Matsunaga
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan; Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of Medicine, Fukuoka, Japan.
Keijiro
K
Saku
Acute decompensated heart failure; Change in body weight index; Predictor of prognosis