Measurement of tidal breathing flows in infants using impedance pneumography.
Tidal breathing flow volume (TBFV) profiles have been used to characterise altered lung function. Impedance pneumography (IP) is a novel option for assessing TBFV curves noninvasively. The aim of this study was to extend the application of IP for infants and to estimate the agreement between IP and direct pneumotachograph (PNT) measurements in assessing tidal airflow and flow-derived indices.Tidal flow profiles were recorded for 1 min simultaneously with PNT and uncalibrated IP at baseline in 44 symptomatic infants, and after methacholine-induced bronchoconstriction in a subgroup (n=20).The agreement expressed as the mean deviation from linearity ranged between 3.9 and 4.3% of tidal peak inspiratory flow, but was associated with specific airway conductance (p=0.002) and maximal flow at functional residual capacity (V'maxFRC) (p=0.004) at baseline. Acute bronchoconstriction induced by methacholine did not significantly affect the agreement of IP with PNT. TBFV indices derived from IP were slightly underestimated compared to PNT, but were equally well repeatable and associated with baselineV'maxFRC(p=0.012 and p=0.013, respectively).TBFV profiles were consistent between IP and PNT in most infants, but the agreement was affected by reduced lung function. TBFV parameters were not interchangeable between IP and PNT, but had a similar association with lung function in infants.
Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland pekka.malmberg@hus.fi.
Leo Pekka
LP
Malmberg
Dept of Electronics and Communications Engineering, Tampere University of Technology, BioMediTech, Tampere, Finland.
Ville-Pekka
VP
Seppä
Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anne
A
Kotaniemi-Syrjänen
Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Kristiina
K
Malmström
Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Merja
M
Kajosaari
Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anna S
AS
Pelkonen
Dept of Electronics and Communications Engineering, Tampere University of Technology, BioMediTech, Tampere, Finland.
Jari
J
Viik
Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mika J
MJ
Mäkelä
D000402:Airway Obstruction / Q000503:physiopathology*; D016085:Bronchoconstrictor Agents / Q000008:administration & dosage; D002675:Child, Preschool; D017097:Electric Impedance; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D007223:Infant; D008168:Lung / Q000503:physiopathology*; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage; D012129:Respiratory Function Tests; D062606:Tertiary Care Centers; D013990:Tidal Volume
D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride