Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance.
Background. It has been reported that circRNAs are differentially expressed in a wide range of cancers and could be used as a new biomarker for diagnosis. However, the correlation between circRNAs and gastric cancer (GC) it is still unclear.Materials and Methods. In this study, by using real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs), we detected the expression level of hsa_circ_0001649 in tissue and serum samples from GC patients.Results. We found that hsa_circ_0001649 expression was significantly downregulated in GC tissue compared with their paired paracancerous histological normal tissues (PCHNTs) (P< 0.01). We next analyzed the expression level of hsa_circ_0001649 in serum samples between preoperative and postoperative GC patients. We found that its level in serum was significantly upregulated after surgery (P< 0.01). The area under the receiver operating characteristic (ROC) curve was 0.834. Moreover, the expression level of hsa_circ_0001649 was significantly correlated with pathological differentiation (P= 0.039).Conclusion. Our test suggested that hsa_circ_0001649 was significantly downregulated in GC and may become a novel potential biomarker in the diagnosis of GC.
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Wen-Han
WH
Li
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yong-Chun
YC
Song
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Hao
0000-0001-8986-3854
H
Zhang
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Zhang-Jian
ZJ
Zhou
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Xin
X
Xie
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Qing-Nuo
QN
Zeng
The Second Subsidiary Hospital, Fourth Military Medical University, Xi'an, China.
Kun
K
Guo
The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Ting
T
Wang
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Peng
P
Xia
The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Dong-Min
0000-0002-2448-245X
DM
Chang
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D045744:Cell Line, Tumor; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012313:RNA / Q000097:blood / Q000378:metabolism*; D000079962:RNA, Circular; D013274:Stomach Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D000079962:RNA, Circular; D012313:RNA