Comparison of brain serotonin transporter using [I-123]-ADAM between obese and non-obese young adults without an eating disorder.
Cerebral serotonin metabolism has an important but controversial role in obesity. However, it is not given enough attention in morbidly obese young adults. We used single photon emission computed tomography (SPECT) with [I-123]-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) to investigate changes in serotonin transporter (SERT) availability in 10 morbidly obese young adults without an eating disorder (M/F = 5/5, body mass index (BMI): 40.3 ± 4.1 kg/m2, percentage of body fat (BF%): 46.0 ± 3.9%) and 10 age- and sex-matched non-obese controls (BMI: 20.3 ± 1.2 kg/m2, BF%: 20.6 ± 8.9%). All participants underwent SPECT at 10 min and 6 h after an injection of 200 MBq of [I-123]-ADAM. The SERT binding site (midbrain) was drawn with cerebellum normalization. The BF% and fat distribution were measured using dual-energy X-ray absorptiometry. The midbrain/cerebellum SERT binding ratios (2.49 ± 0.46 vs. 2.47 ± 0.47; p = 0.912) at 6 h were not significantly different between groups, nor was the distribution of the summed images at 10 min (1.36 ± 0.14 vs. 1.35 ± 0.11; p = 0.853). There were no significant correlations between midbrain/cerebellum SERT binding ratio and age, BMI, BF%, or fat distribution. No significant difference in SERT availability in the midbrain between morbidly obese and non-obese young adults without an eating disorder indicates an unmet need for investigating the role of cerebral serotonin in obesity.
Departments of Family Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan.|Institutes of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.|Institutes of Gerontology, National Cheng Kung University College of Medicine, Tainan, Taiwan.
Chih-Hsing
CH
Wu
Departments of Family Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan.|Institutes of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.
Chin-Sung
CS
Chang
Institutes of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.|Departments of Psychiatry, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan.
Yen Kuang
YK
Yang
Institute of Nuclear Energy Research, Longtan Township, Taoyuan County, Taiwan.
Lie-Hang
LH
Shen
Departments of Nuclear Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan.
Wei-Jen
WJ
Yao
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D016022:Case-Control Studies; D002928:Cinanserin / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000000981:diagnostic imaging* / Q000378:metabolism; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D002928:Cinanserin