Regulation of antimicrobial resistance by extracytoplasmic function (ECF) sigma factors.
Extracytoplasmic function (ECF) sigma factors are a subfamily of σ70sigma factors that activate genes involved in stress-response functions. In many bacteria, ECF sigma factors regulate resistance to antimicrobial compounds. This review will summarize the ECF sigma factors that regulate antimicrobial resistance in model organisms and clinically relevant pathogens.
Department of Microbiology and Immunology, Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA.
Emily C
EC
Woods
Department of Microbiology and Immunology, Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: shonna.mcbride@emory.edu.
Shonna M
SM
McBride
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism; D016360:Clostridioides difficile / Q000235:genetics / Q000472:pathogenicity; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D013293:Enterococcus faecalis / Q000235:genetics / Q000472:pathogenicity; D004926:Escherichia coli / Q000235:genetics / Q000472:pathogenicity; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000472:pathogenicity; D012475:Salmonella / Q000235:genetics / Q000472:pathogenicity; D012808:Sigma Factor / Q000235:genetics*; D048372:Streptomyces coelicolor / Q000235:genetics / Q000378:metabolism; D013312:Stress, Physiological / Q000235:genetics*
D000900:Anti-Bacterial Agents; D012808:Sigma Factor; C063202:sporulation-specific sigma factors; C081775:RNA polymerase sigma 70; D012321:DNA-Directed RNA Polymerases
Antimicrobial resistance; ECF sigma factors; Extracytoplasmic function sigma factors; Regulation