Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes.
Leukemia Program, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
R T
RT
Swords
Leukemia Program, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
J
J
Watts
Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA.
H P
HP
Erba
Northwestern Medicine Developmental Therapeutics Institute, Northwestern University, Chicago, IL, USA.
J K
JK
Altman
Colorado Blood Cancer Institute, Denver, CO, USA.
M
M
Maris
University of Arizona Cancer Center, Tucson, AZ, USA.
F
0000-0001-6914-7439
F
Anwer
T Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
Z
Z
Hua
T Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
H
H
Stein
T Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
H
H
Faessel
T Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
F
F
Sedarati
T Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
B J
BJ
Dezube
Northwestern Medicine Developmental Therapeutics Institute, Northwestern University, Chicago, IL, USA.
F J
FJ
Giles
Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA.
B C
BC
Medeiros
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
D J
DJ
DeAngelo
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003517:Cyclopentanes / Q000008:administration & dosage / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D000075687:NEDD8 Protein / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D000075687:NEDD8 Protein; C082860:NEDD8 protein, human; D011743:Pyrimidines; C539933:pevonedistat