Serum Anti-Müllerian Hormone and Inhibin B as Potential Markers for Progressive Central Precocious Puberty in Girls.
OBJECTIVE
To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels as markers for pubertal progression rate in girls with central precocious puberty (CPP). DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A total of 148 girls were enrolled, including 65 girls with premature thelarche and 83 girls with CPP, grouped on the basis of the results of gonadotropin-releasing hormone stimulation tests. Girls with CPP underwent a 6-month follow-up, and were further divided into 2 subgroups: the progressive CPP (P-CPP) group (n = 55) and the slowly P-CPP (SP-CPP) group (n = 28). Serum AMH and INHB levels were assessed in all enrolled girls. Using receiver operating characteristic curves, we analyzed the diagnostic performance of AMH and INHB to differentiate the 2 forms of CPP.


RESULTS
Our data showed that AMH and INHB offer the potential to act as markers that distinguish SP-CPP from P-CPP. Compared with the SP-CPP group, girls with P-CPP showed lower AMH levels and higher INHB levels. On the basis of the receiver operating characteristics analysis, the area under the curve was 0.92 for the combination of AMH and INHB, with 80% sensitivity and 89.3% specificity.


CONCLUSIONS
Our results suggest that serum AMH and INHB levels provide a promising method in differentiating SP-CPP from P-CPP.
Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Ting
T
Chen
Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Haiying
H
Wu
Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Rongrong
R
Xie
Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Fengyun
F
Wang
Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiuli
X
Chen
Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Hui
H
Sun
Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: clq631203@aliyun.com.
Linqi
L
Chen
D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007265:Inhibins / Q000097:blood*; D011629:Puberty, Precocious / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity
D015415:Biomarkers; C422364:inhibin B; D007265:Inhibins; D054304:Anti-Mullerian Hormone
Anti-Müllerian hormone; Central precocious puberty; Inhibin B