Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl4Induced Liver Toxicity in Rat.
The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract ofAnethum graveolens(dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats' liver. Thiol groups' oxidation, amyloid cross-β, and protein fragmentation (P< 0.001) significantly reduced in treated rats. Liver damage markers significantly reduced in dill-treated animals (P< 0.05). Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Ebrahim Abbasi
0000-0002-3405-562X
EA
Oshaghi
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Iraj
I
Khodadadi
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fatemeh
F
Mirzaei
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mozafar
M
Khazaei
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Heidar
H
Tavilani
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Mohammad Taghi
0000-0002-5546-5812
MT
Goodarzi