Regulation and functions of NLRP3 inflammasome during influenza virus infection.
The NLRP3 inflammasome constitutes a major antiviral host defense mechanism during influenza virus infection. Inflammasome assembly in virus-infected cells facilitates autocatalytic processing of pro-caspase-1 and subsequent cleavage and secretion of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome is critical for induction of both innate and adaptive immune responses during influenza virus infection. Inflammasome-dependent antiviral responses also regulate immunopathology and tissue repair in the infected lungs. The regulation of NLRP3 inflammasome assembly is an area of active research and recent studies have unraveled multiple cellular and viral factors involved in inflammasome assembly. Emerging studies have also identified the cross talk between inflammasome activation and programmed cell death pathways in influenza virus-infected cells. Here, we review the current literature regarding regulation and functions of NLRP3 inflammasome during influenza virus infection.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Teneema
T
Kuriakose
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: Thirumala-Devi.Kanneganti@STJUDE.ORG.
Thirumala-Devi
TD
Kanneganti
D020170:Caspase 1 / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism; D009980:Influenza A virus / Q000276:immunology* / Q000472:pathogenicity; D007251:Influenza, Human / Q000276:immunology* / Q000473:pathology; D020382:Interleukin-18 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000378:metabolism*; D000069292:Pyroptosis; D016601:RNA-Binding Proteins; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism
D004268:DNA-Binding Proteins; D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D016601:RNA-Binding Proteins; C485731:ZBP1 protein, human; C119705:RIPK3 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; D020170:Caspase 1
Caspase-1; Inflammasome; Influenza virus; NLRP3; RIPK3; ZBP1