Analgesia induced by self-initiated electrotactile sensation is mediated by top-down modulations.
It is well known that sensory perception can be attenuated when sensory stimuli are controlled by self-initiated actions. This phenomenon is explained by the consistency between forward models of anticipated action effects and actual sensory feedback. Specifically, the brain state related to the binding between motor processing and sensory perception would have inhibitory function by gating sensory information via top-down control. Since the brain state could casually influence the perception of subsequent stimuli of different sensory modalities, we hypothesize that pain evoked by nociceptive stimuli following the self-initiated tactile stimulation would be attenuated as compared to that following externally determined tactile stimulation. Here, we compared psychophysical and neurophysiological responses to identical nociceptive-specific laser stimuli in two different conditions: self-initiated tactile sensation condition (STS) and nonself-initiated tactile sensation condition (N-STS). We observed that pain intensity and unpleasantness, as well as laser-evoked brain responses, were significantly reduced in the STS condition compared to the N-STS condition. In addition, magnitudes of alpha and beta oscillations prior to laser onset were significantly larger in the STS condition than in the N-STS condition. These results confirmed that pain perception and pain-related brain responses were attenuated when the tactile stimulation was initiated by subjects' voluntary actions, and exploited neural oscillations reflecting the binding between motor processing and sensory feedback. Thus, our study elaborated the understanding of underlying neural mechanisms related to top-down modulations of the analgesic effect induced by self-initiated tactile sensation, which provided theoretical basis to improve the analgesic effect in various clinical applications.
CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Ke
K
Zhao
Faculty of Psychology, Southwest University, Chongqing, China.
Zhengyu
Z
Tang
Faculty of Psychology, Southwest University, Chongqing, China.
Huiquan
H
Wang
CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Yifei
Y
Guo
Brain Function and Psychological Science Research Center, Shenzhen University, Shenzhen, China.
Weiwei
W
Peng
CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.|Faculty of Psychology, Southwest University, Chongqing, China.
Li
L
Hu
D000293:Adolescent; D000698:Analgesia / Q000379:methods*; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006358:Hot Temperature; D006801:Humans; D066331:Laser-Evoked Potentials / Q000502:physiology*; D008297:Male; D010146:Pain / Q000503:physiopathology*; D014110:Touch / Q000502:physiology*; D055698:Touch Perception / Q000502:physiology*; D055815:Young Adult
Alpha oscillations; Analgesia; Sensory attenuation; Tactile sensation; Top-down modulations