Ruthenium(0)-Catalyzed C-C Coupling of Alkynes and 3-Hydroxy-2-oxindoles: Direct C-H Vinylation of Alcohols.
Upon exposure to a ruthenium(0) catalyst, N-benzyl-3-hydroxy-2-oxindoles react with diverse alkynes to form products of C-H vinylation with complete control of regioselectivity and olefin geometry. This method contributes to a growing body of catalytic processes that enable direct conversion of lower alcohols to higher alcohols in the absence of stoichiometric organometallic reagents.
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Tom
T
Luong
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Shujie
S
Chen
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Ke
K
Qu
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Emma L
EL
McInturff
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Michael J
0000-0001-8418-9709
MJ
Krische
D000438:Alcohols / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D010084:Oxidation-Reduction; D000078183:Oxindoles / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D000438:Alcohols; D000475:Alkenes; D000480:Alkynes; D056831:Coordination Complexes; D008024:Ligands; D000078183:Oxindoles; C022960:2-oxindole; D012428:Ruthenium