Evaluation of cardiac microvasculature in patients with diffuse myocardial fibrosis.
Myocardial fibrosis is one of the most common histopathological lesions found in chronic heart diseases. Progressive development of myocardial fibrosis will cause heart failure, an extremely debilitating and life threatening condition. The correlation between the severity of fibrosis and myocardial microcirculation is an important prognostic factor in this disease entity. In our study, myocardial microvascular density evaluation of the patients with high blood pressure (hypertension), atrial fibrillation (AF), coronary heart disease, and heart failure showed a significant decrease of the values of this parameter, which means that myocardial fibrosis is the direct result of stimulation of myocardial fibroblasts induced by local hypoxia.
Department of Anatomy, University of Medicine and Pharmacy of Craiova, Romania; danapirici@yahoo.com.
Octavian
O
Istrătoaie
Ionica
I
Pirici
Anca Maria
AM
OfiŢeru
Florin
F
Grosu
Alice
A
Brînzea
Lavinia
L
Olar
Ion Cristian
IC
Efrem
D005260:Female; D005355:Fibrosis / Q000473:pathology*; D006331:Heart Diseases / Q000473:pathology*; D006801:Humans; D008297:Male; D055806:Microvessels / Q000473:pathology; D009206:Myocardium / Q000473:pathology*