Organocatalytic Hydrophosphonylation Reaction of Carbonyl Groups.
This revision is covering the limited examples reported for a pivotal strategy in the formation of C-P bonds such as the asymmetric organocatalytic hydrophosphonylation of carbonyl groups (Pudovik reaction). The scope and limitations, and the proposed mechanisms for the scarce different possibilities of asymmetric induction are also shown. The recent evolution and future trends of this undeveloped approach are commented.
Laboratorio de Organocatálisis Asimétrica. Departamento de Química Orgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH) CSIC-, Universidad de Zaragoza, C/ Pedro Cerbuna N°12, 50009, Zaragoza, Spain.
Raquel P
RP
Herrera
Pudovik; asymmetry; hydrophosphonylation; organocatalysis; phosphite; α-hydroxy phosphonates