CuCo2S4nanocrystals: a new platform for multimodal imaging guided photothermal therapy.
Multifunctional nanomaterials open an avenue for the integration of cancer treatment and diagnosis, trending towards the clinical application of nanomedicines in future. Herein, we synthesized biocompatible CuCo2S4nanocrystals (NCs) via a simple reflux method and unitized them as a new theranostic platform, where an intense near-infrared (NIR) absorption offers the CuCo2S4NCs a perfect photothermal performance and photoacoustic (PA) imaging ability; the magnetic characteristic of Co allows them to serve as an enhanced magnetic resonance (MR) contrast agent. The in vitro and in vivo experiments demonstrated their good biocompatibility, non-toxicity and perfect photothermal conversion performance and further confirmed that HeLa tumors could be effectively thermal-ablated upon the assistance of the CuCo2S4NCs. This work introduces the first bioapplication of the CuCo2S4NCs and promotes theranostics based on other ternary compounds.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
Xiaojuan
X
Huang
Trauma Center of Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China.
Guoying
G
Deng
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
Lijun
L
Liao
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
Wenlong
W
Zhang
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
Guoqiang
G
Guan
Trauma Center of Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China.
Feng
F
Zhou
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
Zhiyin
Z
Xiao
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
Rujia
http://orcid.org/0000-0001-5566-5091
R
Zou
Trauma Center of Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China.
Qian
Q
Wang
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
Junqing
http://orcid.org/0000-0001-8422-7250
J
Hu
D000818:Animals; D001672:Biocompatible Materials; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D064847:Multimodal Imaging; D053758:Nanoparticles; D010789:Phototherapy; D000068936:Theranostic Nanomedicine
D001672:Biocompatible Materials