Resolving Late-Stage Intermediates of Eukaryotic Ribosome Assembly.
The assembly of eukaryotic ribosomes requires about 200 assembly factors promoting RNA modification, folding, cleavage, and ribosomal protein association. In this issue of Structure, Johnson et al. (2017) report structures of several late-stage intermediates of pre-40S ribosomal subunit assembly. This work provides detailed testable insights into assembly factor function.
Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Erik W
EW
Hartwick
Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA. Electronic address: brian.wimberly@ucdenver.edu.
Brian T
BT
Wimberly
D056890:Eukaryota; D005057:Eukaryotic Cells; D012269:Ribosomal Proteins / Q000032:analysis*; D012270:Ribosomes / Q000737:chemistry
D012269:Ribosomal Proteins