Relationship between LINC00341 expression and cancer prognosis.
LINC00341 is a novel long intergenic non-protein coding RNA with unknown functions. In our report, we investigated LINC00341 expression and its prognostic value in cancer patients. DNA over-methylation triggered low expression of LINC00341 and that was associated with poor prognosis in cancers. A meta-analysis further confirmed that high expression of LINC00341 was associated with a better prognosis in cancer patients. Both gene set enrichment analysis and meta-analysis showed that LINC00341 inhibited cancer metastasis. Finally, a large-scale multicentre analysis supported a prognostic value of LINC00341 in cancers.
School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.|Key Laboratory in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China.
Meijian
M
Liao
School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.|Key Laboratory in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China.
Bing
B
Li
Key Laboratory in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China.
Shikuan
S
Zhang
School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.|Key Laboratory in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China.
Qing
Q
Liu
School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.|Key Laboratory in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China.
Weijie
W
Liao
Key Laboratory in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China.|Open FIESTA Center, Tsinghua University, Shenzhen 518055, P.R. China.
Weidong
W
Xie
Key Laboratory in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China.|Open FIESTA Center, Tsinghua University, Shenzhen 518055, P.R. China.
Yaou
Y
Zhang
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D015201:Meta-Analysis as Topic; D015337:Multicenter Studies as Topic; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*
D062085:RNA, Long Noncoding; C000621675:long non-coding RNA LINC00341, human
LINC00341; LncRNA; meta-analysis; metastasis; prognostication