Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study.
OBJECTIVE
The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor.


METHODS
A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of LEEP (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.


RESULTS
Patients characteristics were comparable in terms of excised specimen thickness and pathological analysis, as well as for tobacco intoxication during pregnancy. Although there was no difference of term at delivery or total number of preterm adverse obstetrical events, we found a significant increase of events (19% vs 4.1%) and PL (19% vs 0%) before 26 WA in the group of patients younger than 25 years. After adjusting for excised specimen thickness, the same results were found for thickness of 15 mm or less (respectively, 16.7% vs 3.3% and 16.7% vs 0%). For thickness of greater than 15 mm, only ratio of PL before 26 WA was higher in the group of patients younger than 25 years (33.3% vs 0%).


CONCLUSIONS
Age younger than 25 years at the time of LEEP seems to be is associated with a more frequent occurrence of extremely early preterm adverse obstetrical events, particularly PL.
Department of 1Gynecology and 2Clinical Pathology, University Hospital of Amiens; and Picardie-Jules Vernes University, Amiens, France.
Julien
J
Chevreau
Antonin
A
Mercuzot
Arthur
A
Foulon
Chirstophe
C
Attencourt
Fabrice
F
Sergent
Ségolène
S
Lanta
Jean
J
Gondry
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D019092:Conization / Q000009:adverse effects*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology*; D006801:Humans; D007752:Obstetric Labor, Premature / Q000453:epidemiology*; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000628:therapy*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000628:therapy*