Measuring Analytical Quality: Total Analytical Error Versus Measurement Uncertainty.
To characterize analytical quality of a laboratory test, common practice is to estimate Total Analytical Error (TAE) which includes both imprecision and trueness (bias). The metrologic approach is to determine Measurement Uncertainty (MU), which assumes bias can be eliminated, corrected, or ignored. Resolving the differences in these concepts and approaches is currently a global issue.
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA; Westgard QC, Inc, Madison, WI 53717, USA. Electronic address: james@westgard.com.
James O
JO
Westgard
Westgard QC, Inc, Madison, WI 53717, USA.
Sten A
SA
Westgard
D019411:Clinical Laboratory Techniques / Q000592:standards*; D000068598:Data Accuracy; D003951:Diagnostic Errors; D006801:Humans; D011786:Quality Control; D012016:Reference Values; D015203:Reproducibility of Results; D035501:Uncertainty
Accuracy; Allowable total error (ATE); Bias; Measurement uncertainty (MU); Total analytical error (TAE)