Post-translationally modified frog skin-derived antimicrobial peptides are effective against Aeromonas sobria.
Antimicrobial peptides (brevinin1 HYba1 and brevinin1 HYba2) identified from the skin secretion of an endemic frog species of Western Ghats were studied against fish pathogens. Post-translational modifications such as c-terminal amidation and cyclization of the peptides were enhanced on the activity against Aeromonas sobria. Based on the Minimum inhibitory concentration (3 μM), cyclic amidated brevinin Hyba2 was identified as the most promising antimicrobial agent against A. sobria and can be developed further as a lead drug molecule.
Molecular Ecology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India.
Vineethkumar
V
Tv
Chemical Biology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India.
Asha
A
R
Molecular Ecology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India.
Shyla
S
G
Molecular Ecology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India. Electronic address: sgeorge@rgcb.res.in.
Sanil
S
George
D000333:Aeromonas / Q000187:drug effects*; D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D001001:Anura; D008826:Microbial Sensitivity Tests; D011499:Protein Processing, Post-Translational; D012867:Skin / Q000737:chemistry
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides
Antimicrobial peptides; Endemic frog; Fish pathogen; Post-translational modification