Correlation between cervical infection and preterm labor.
Aim To investigate a correlation between cervical canal infection and imminent preterm labor and to identify most frequent pathogens. Methods A prospective study was conducted in obstetrics/gynecology departments of Health Center and the University Clinical Center Tuzla, and General Hospital Tešanj (Bosnia and Herzegovina, B&H) between October 2013 and May 2014. An examined group included 50 healthy pregnant women with singleton pregnancy of the gestation age between the 28th and 37th week, with cervical changes that are related to imminent preterm labor. Changes were detected by ultrasound biometry of cervix and modified Bishop score. A control group included 30 healthy pregnant women with singleton pregnancy of the gestation age between the 28th and 37th week of pregnancy without signs of imminent preterm labor. Cervical mucus was microbiologically analyzed for identification of pathogens. Results The infection in cervical canal was proven in 35 (70%) examinees and four (13%) patients from the control group (p=0.015). In seven (20%) cases each Ureaplasma and Mycoplasma were detected followed by E. coli in five (14%) cases (p=0.001). Conclusion Cervical canal infection is associated with changes on cervix and premature rupture of fetal membranes, i.e. preterm labor and imminent preterm labor. Screening for infection before pregnancy should be the main task of family doctors as well as gynecologists.
Department of Gynecology and Obstetrics, General Hospital, Tešanj; Bosnia and Herzegovina.
Larisa
L
Mešić Ðogić
Hospital for Obstetrics and Gynecology, Clinical Hospital Centre, Banja Luka; Bosnia and Herzegovina.
Nenad
N
Lučić
Hospital for Obstetrics and Gynecology, Clinical Hospital Centre Dragiša Mišović, Belgrade, Serbia.
Dragana
D
Mićić
School of Medicine, University of Tuzla, Obstetrics and Gynecology Practice "Omeragić", Tuzla; Bosnia and Herzegovina.
Feđa
F
Omeragić
Department of Surgery, General Hospital Tešanj; Bosnia and Herzegovina.
Enes
E
Hodžić
Department of Surgery, General Hospital Tešanj; Bosnia and Herzegovina.
Seid
S
Fazlagić
Department of Pediatrics; General Hospital Tešanj, Bosnia and Herzegovina.
Refka
R
Kovač
Institute of Public Health of Belgrade, Serbia.
Nevenka
N
Pavlović
D001424:Bacterial Infections / Q000150:complications / Q000000981:diagnostic imaging*; D017522:Bosnia and Herzegovina / Q000453:epidemiology; D002584:Cervix Uteri / Q000000981:diagnostic imaging* / Q000382:microbiology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000000981:diagnostic imaging* / Q000382:microbiology; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology; D011296:Prenatal Diagnosis; D011446:Prospective Studies
pregnancy complication; premature birth; uterine cervicitis