Continuous Electroencephalography (cEEG) Monitoring and Outcomes of Critically Ill Patients.
BACKGROUND It is not clear whether performing continuous EEG (cEEG) in critically ill patients during intensive care unit (ICU) treatment affects outcomes at discharge. MATERIAL AND METHODS We prospectively matched 234 patients who received cEEG (cases) by admission diagnosis and sex to 234 patients who did not receive cEEG (controls) and followed them until discharge. Patients admitted due to seizures were excluded. The primary measures of outcome were Glasgow Coma Scale at Discharge (GCSD) and disposition at discharge, and the secondary measures of outcome were AED modifications, Glasgow Outcomes Scale, and Modified-Rankin Scale. These outcomes were compared between the cases and controls. RESULTS Some differences in primary outcome measures between the groups emerged on univariate analyses, but these differences were small and not significant after controlling for covariates. Cases had longer ICU stays (p=0.002) and lower admission GCS (p=0.01) but similar GCSD (p=0.10). Of the secondary outcome measures, the mean (SD) number of AED modifications for cases was 2.2±3.1 compared to 0.4±0.8 for controls (p<0.0001); 170 (72.6%) cases had at least 1 AED modification compared to only 56 (24.1%) of the controls (p<0.0001). CONCLUSIONS Performing cEEG did not improve discharge outcome but it significantly influenced AED prescription patterns. Further studies assessing long-term outcomes are needed to better define the role of cEEG in this patient population.
Department of Neurology, University of Alabama at Birmingham (UAB) Hospital, Birmingham, AL, USA.|Department of Neurology, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA.
Ayaz M
AM
Khawaja
Department of Biostatistics, University of Alabama at Birmingham (UAB) Hospital, Birmingham, AL, USA.
Guoqiao
G
Wang
Department of Biostatistics, University of Alabama at Birmingham (UAB) Hospital, Birmingham, AL, USA.
Gary R
GR
Cutter
Department of Neurology, University of Alabama at Birmingham (UAB) Hospital, Birmingham, AL, USA.|University of Alabama at Birmingham (UAB) Epilepsy Center, Birmingham, AL, USA.
Jerzy P
JP
Szaflarski
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003422:Critical Care; D016638:Critical Illness / Q000628:therapy*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D010351:Patient Discharge; D011446:Prospective Studies; D012640:Seizures; D016896:Treatment Outcome