Role of RUNX1 in hematological malignancies.
RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of definitive hematopoiesis in vertebrates.RUNX1is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations inRUNX1cause familial platelet disorder with associated myeloid malignancies. Somatic mutations and chromosomal rearrangements involvingRUNX1are frequently observed in myelodysplastic syndrome and leukemias of myeloid and lymphoid lineages, that is, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia. More recent studies suggest that the wild-typeRUNX1is required for growth and survival of certain types of leukemia cells. The purpose of this review is to discuss the current status of our understanding about the role of RUNX1 in hematological malignancies.
Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; and.
Raman
0000-0001-5565-662X
R
Sood
Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yasuhiko
Y
Kamikubo
Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; and.
Paul
0000-0002-6779-025X
P
Liu
D000208:Acute Disease; D000818:Animals; D002869:Chromosome Aberrations; D002908:Chronic Disease; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism
D050676:Core Binding Factor Alpha 2 Subunit; D009363:Neoplasm Proteins; C493728:RUNX1 protein, human