Whole-Brain High-Resolution Structural Connectome: Inter-Subject Validation and Application to the Anatomical Segmentation of the Striatum.
The present study describes extraction of high-resolution structural connectome (HRSC) in 99 healthy subjects, acquired and made available by the Human Connectome Project. Single subject connectomes were then registered to the common surface space to allow assessment of inter-individual reproducibility of this novel technique using a leave-one-out approach. The anatomic relevance of the surface-based connectome was examined via a clustering algorithm, which identified anatomic subdivisions within the striatum. The connectivity of these striatal subdivisions were then mapped on the cortical and other subcortical surfaces. Findings demonstrate that HRSC analysis is robust across individuals and accurately models the actual underlying brain networks related to the striatum. This suggests that this method has the potential to model and characterize the healthy whole-brain structural network at high anatomic resolution.
Aix Marseille Université, CNRS, CRMBM, 7339, Marseille, France. besson.pierre@gmail.com.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 264 rue Saint-Pierre, Marseille, 13385, France. besson.pierre@gmail.com.
Pierre
http://orcid.org/0000-0002-0591-7542
P
Besson
U1171, INSERM, Université de Lille, Lille, France.|Neurology and Movement disorders Department, Lille University Hospital, Lille, France.
Nicolas
N
Carrière
Aix Marseille Université, CNRS, CRMBM, 7339, Marseille, France.|AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 264 rue Saint-Pierre, Marseille, 13385, France.
S Kathleen
SK
Bandt
Université de Lille, CRIStAL UMR9189, INRIA, Magnet Team, Lille, France.
Marc
M
Tommasi
Clinical Imaging Core Facility, INSERM U1171, Lille University Hospital, Lille, France.
Xavier
X
Leclerc
U1171, INSERM, Université de Lille, Lille, France.|Department of Clinical Neurophysiology, Lille University Hospital, Lille, France.
Philippe
P
Derambure
Clinical Imaging Core Facility, INSERM U1171, Lille University Hospital, Lille, France.
Renaud
R
Lopes
Department of Neurology, Nancy University Hospital, Nancy, France.|CRAN, UMR CNRS 7039, University of Lorraine, Nancy, France.
Louise
L
Tyvaert
D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology; D063132:Connectome; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D015203:Reproducibility of Results; D055815:Young Adult
Connectome; Diffusion magnetic resonance imaging; High-resolution; Striatum clustering; Surface-based connectivity