Encapsulating Peritoneal Sclerosis.
Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis. In this review, we describe the clinical picture and histologic changes to the peritoneal membrane that are associated with EPS and provide an update on current diagnosis and management. We also discuss the recent studies that have suggested that the use of more biocompatible solutions containing lower concentrations of glucose degradation product that often are pH neutral in combination with a change in clinical practice (reducing glucose exposure and monitoring peritoneal membrane function) might ameliorate peritoneal degeneration, reduce the incidence of EPS, and minimize the severity of the disease.
Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, UK.
Helen
H
Alston
Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, UK. Electronic address: s.fan@qmul.ac.uk.
Stanley
S
Fan
Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine, Fukushima, Japan.
Masaaki
M
Nakayama
D015314:Dialysis Solutions / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods*; D056627:Peritoneal Fibrosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D010537:Peritoneum / Q000473:pathology
D015314:Dialysis Solutions
EPS; Encapsulating peritoneal sclerosis; peritoneal dialysis; peritoneal membrane