The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality.
Over the last 15 years, we have seen a huge expansion of the development of drugs directed against biomolecular targets within breast cancer cells. The over-expression of certain receptors (ER, PgR, HER-2, VEGF-R), as well as alteration of several intracellular signal transduction pathways (the PI3K-AKT-mTOR pathway, MEK-MAPK pathway, loss of PTEN, etc ...) has a great impact on the likelihood of recurrence and progression of the disease, influencing the natural history of breast cancer. The recent biomolecular classification of breast cancer (Luminal A / B, HER2- driven, Basal Like) allowed finally to identify specific treatments against molecular target to associate or not to traditional chemotherapy, and to use in relation to the prognosis of the disease. In the following paragraphs, we will set out the major targeted drug that have received indications in breast cancer, both in the localized and in advanced disease, referring to the specific target (hormonal receptors, HER2, VEGF, m-TOR, PARP etc ...).
Division of Medical Oncology, "Umberto I" Hospital - RAO - Siracusa, Italy.
Sebastiano
S
Bordonaro
Department of Medical Oncology, National Cancer Institute Aviano (PN), Italy.
Massimiliano
M
Berretta
Division of Medical Oncology, "Umberto I" Hospital - RAO - Siracusa, Italy.
Antonino Carmelo
AC
Tralongo
Division of Medical Oncology, "Umberto I" Hospital - RAO - Siracusa, Italy.
Silvia
S
Clementi
Department of Medical Oncology, National Cancer Institute Aviano (PN), Italy.
Brigida
B
Stanzione
Division of Medical Oncology, "Umberto I" Hospital - RAO - Siracusa, Italy.
Paolo
P
Tralongo
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D057285:Precision Medicine; D011379:Prognosis
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins
Breast; biomolecular; cancer; metastases; receptors; target; treatment.