Incidence of Idiopathic Ventricular Arrhythmias: A Population-Based Study.
BACKGROUND
Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, the burden of idiopathic ventricular arrhythmias (IVA) in the general population is unknown.


RESULTS
We identified incident cases of IVA between 2005 and 2013 from Olmsted County, Minnesota, using the Rochester Epidemiology Project database. For PVC cohorts, we included those with frequent (defined as ≥100 PVC/24 hours) symptomatic PVCs. We defined IVA-associated cardiomyopathy as a drop in ejection fraction of ≥10% from baseline. Between 2005 and 2013, we identified 614 individuals with incident IVA (229 [37.3%] were male; average age was 52.1±17.2 years). Of these, 177 (28.8%) had idiopathic ventricular tachycardia, 408 (66.5%) had symptomatic PVCs, and 29 (4.7%) had IVA-associated cardiomyopathy. The age- and sex-adjusted incidence rates in 2005 to 2007, 2008 to 2010, and 2011 to 2013 were 44.9 per 100 000 (95% confidence interval [CI], 38.0-51.8), 47.6 per 100 000 (95% CI, 40.8-54.5), and 62.0 per 100 000 (95% CI, 54.4-69.6), respectively. In idiopathic ventricular tachycardia, there was an increase in incidence rate with ages (P<0.001) but not between sexes (P=0.12). The age-adjusted incidence of symptomatic PVC was higher in females than in males (46.2 per 100 000 [95% CI, 40.9-51.6] versus 20.5 per 100 000 [95% CI, 16.8-24.3];P<0.001). The small number of individuals with IVA-associated cardiomyopathy precluded any formal testing.


CONCLUSIONS
The incidence of IVA is increasing. Furthermore, overall incidence increases with age. Although the rate of idiopathic ventricular tachycardia is similar across sexes, women have a higher incidence of symptomatic PVC.
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Surksha
S
Sirichand
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Ammar M
AM
Killu
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Deepak
D
Padmanabhan
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
David O
DO
Hodge
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Alanna M
AM
Chamberlain
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Peter A
PA
Brady
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Suraj
S
Kapa
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Peter A
PA
Noseworthy
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Douglas L
DL
Packer
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Thomas M
TM
Munger
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Bernard J
BJ
Gersh
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Christopher J
CJ
McLeod
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Win-Kuang
WK
Shen
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Yong-Mei
YM
Cha
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Samuel J
SJ
Asirvatham
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
Paul A
PA
Friedman
From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.). Mulpuru.siva@mayo.edu.
Siva K
SK
Mulpuru
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D017180:Tachycardia, Ventricular / Q000453:epidemiology*; D018879:Ventricular Premature Complexes / Q000453:epidemiology*
epidemiology; idiopathic VT; premature ventricular contraction arrhythmia; ventricular arrhythmia; ventricular tachycardia