Can duration of hemodialysis be estimated based on the on-arrival laboratory tests and clinical manifestations in methanol-poisoned patients?
OBJECTIVE
We aimed to evaluate the efficacy of Lachance formula and more readily available clinical or laboratory factors (other than serum methanol level) in prediction of the needed time for hemodialysis in methanol-poisoned patients.


METHODS
In a retrospective study, all methanol-poisoned patients referred to us between March 2008 and March 2016 were enrolled. The patients' demographic characteristics, on-arrival vital signs, signs/symptoms, and laboratory tests were evaluated for factors that could prognosticate the dialysis duration.


RESULTS
Of 72 patients enrolled, 54 underwent hemodialysis once (group 1) and 18 needed more than one session of hemodialysis (group 2). All were treated by ethanol, bicarbonate, and leucovorin. Lachance formula overestimated the patients in higher methanol levels and underestimated them in lower methanol levels. It properly predicted the needed time for hemodialysis when the methanol level was between 15 and 25 mg/dL. Groups 1 and 2 were different in terms of their ingested alcohol dose (P = 0.001), creatinine (P = 0.02), dyspnea on presentation (P = 0.002), and the place they had been dialyzed (P = 0.013). Dialysis duration significantly correlated with dyspnea on presentation (P = 0.028) and ingested alcohol dose (P = 0.02). After performance of logistic regression analysis, only creatinine was statistically significantly different between the two groups (P = 0.02). Median creatinine levels were 1.3 [1, 6] (0.8-2.7) and 1.4 [1.35, 2.1] (0.8-6.5) in the patients who were dialyzed once and twice, respectively.


CONCLUSIONS
As a conclusion, creatinine is possibly a readily available test that can predict the appropriate time needed for hemodialysis in methanol-poisoned patients.
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.|Excellence Center of Clinical Toxicology, Iranian Ministry of Health, Tehran, Iran.
Abdolkarim
A
Pajoumand
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. nasim.zamani@gmail.com.|Excellence Center of Clinical Toxicology, Iranian Ministry of Health, Tehran, Iran. nasim.zamani@gmail.com.
Nasim
N
Zamani
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.|Excellence Center of Clinical Toxicology, Iranian Ministry of Health, Tehran, Iran.
Hossein
H
Hassanian-Moghaddam
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.|Excellence Center of Clinical Toxicology, Iranian Ministry of Health, Tehran, Iran.
Shahin
S
Shadnia
D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D055641:Mathematical Concepts; D000432:Methanol / Q000097:blood* / Q000506:poisoning*; D008875:Middle Aged; D011041:Poisoning / Q000097:blood / Q000150:complications / Q000628:therapy; D006435:Renal Dialysis; D012189:Retrospective Studies; D013997:Time Factors; D014786:Vision Disorders / Q000139:chemically induced; D055815:Young Adult
D003404:Creatinine; D000432:Methanol
Dialysis; Duration; Methanol; Poisoning