Mapping structural covariance networks of facial emotion recognition in early psychosis: A pilot study.
People with psychosis show deficits recognizing facial emotions and disrupted activation in the underlying neural circuitry. We evaluated associations between facial emotion recognition and cortical thickness using a correlation-based approach to map structural covariance networks across the brain. Fifteen people with an early psychosis provided magnetic resonance scans and completed the Penn Emotion Recognition and Differentiation tasks. Fifteen historical controls provided magnetic resonance scans. Cortical thickness was computed using CIVET and analyzed with linear models. Seed-based structural covariance analysis was done using the mapping anatomical correlations across the cerebral cortex methodology. To map structural covariance networks involved in facial emotion recognition, the right somatosensory cortex and bilateral fusiform face areas were selected as seeds. Statistics were run in SurfStat. Findings showed increased cortical covariance between the right fusiform face region seed and right orbitofrontal cortex in controls than early psychosis subjects. Facial emotion recognition scores were not significantly associated with thickness in any region. A negative effect of Penn Differentiation scores on cortical covariance was seen between the left fusiform face area seed and right superior parietal lobule in early psychosis subjects. Results suggest that facial emotion recognition ability is related to covariance in a temporal-parietal network in early psychosis.
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada. Electronic address: lisabuchy@gmail.com.
Lisa
L
Buchy
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada.
Mariapaola
M
Barbato
McGill Centre for Integrative Neuroscience, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.
Carolina
C
Makowski
Department of Radiology and Paediatrics, University of Calgary, Alberta, Canada; Child and Adolescent Imaging Research (CAIR) Program, Alberta Children's Hospital Research Institute, Alberta, Canada.
Signe
S
Bray
Departments of Psychiatry and Pediatrics, University of Calgary, Alberta, Canada; Strategic Clinical Network for Addictions and Mental Health, Alberta, Canada.
Frank P
FP
MacMaster
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada.
Stephanie
S
Deighton
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada.
Jean
J
Addington
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D005149:Facial Expression; D000066499:Facial Recognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010468:Perceptual Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications* / Q000000981:diagnostic imaging; D055815:Young Adult
Connectivity; Facial affect; First-episode schizophrenia; Magnetic resonance imaging; Social cognition