Y chromosome polymorphisms may contribute to an increased risk of male-induced unexplained recurrent miscarriage.
The present study aims to explore the relationship between the Y chromosome polymorphisms (1qh+, inv(9), 9qh+, 16qh+, group D/G, Yqh- and Yqh+) and the risk of unexplained recurrent miscarriage (URM). A total of 507 couples with URM were recruited as case group and 465 healthy couples as control group. The Y chromosome polymorphisms of the male individuals were analysed with the G-banding technique, and the results of the chromosome G-banding analysis were determined using the International Naming Standards of Human Genetics (ISCN). Logistic regression analysis was used to analyse the risk factors for URM. The detection rate of Y chromosome polymorphisms in the case group (12.03%) was higher than that in the control group (2.15%). Y chromosome polymorphisms were detected at significantly higher rates in the case group than in the control group. Using the normal Y chromosomes in individuals of the case group as reference, the partners of their counterparts were more likely to experience miscarriage. The couples who were Y chromosome-polymorphism carriers had shorter gestational age, increased frequency of URM and longer average interval between pregnancies. The results of logistic regression analysis revealed that Y chromosome polymorphisms, shorter gestational age, a higher frequency of miscarriage and longer pregnancy interval were independent risk factors for URM. Y chromosome polymorphisms may be associated with the risk of URM and may play an important role in the development of URM.
Department of Gynecology and Obstetrics, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, P. R. China.
Yan
Y
Wang
Department of Neurosurgery, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, P. R. China dreaming0425@163.com.
Gang
G
Li
Department of Gynecology and Obstetrics, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, P. R. China.
Man-Zhen
MZ
Zuo
Radiology Department, Traditional Chinese Medicine Hospital of Zhijiang, Yichang, 443000, P. R. China.
Jun-Hua
JH
Fang
Department of Gynecology and Obstetrics, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, P. R. China.
Hai-Rong
HR
Li
Department of Gynecology and Obstetrics, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, P. R. China.
Dan-Dan
DD
Quan
Department of Gynecology and Obstetrics, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, P. R. China.
Lu
L
Huang
Department of Gynecology and Obstetrics, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, P. R. China.
Ping-Ping
PP
Peng
D000026:Abortion, Habitual / Q000097:blood / Q000235:genetics*; D000328:Adult; D002681:China / Q000453:epidemiology; D002871:Chromosome Banding; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D007621:Karyotyping; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012307:Risk Factors
1/9/16qh+; Y chromosome polymorphism; Yqh+; Yqh-; group D/G; inv(9); unexplained recurrent miscarriage