Survival, Morbidity, and Quality-of-Life Outcomes for Sinonasal and Ventral Skull Base Malignancies.
Sinonasal and ventral skull base malignancies are a rare, heterogeneous group of cancers. Although prognosis usually depends on many factors, long-term survival rates remain low despite recent advances. Population-based databases are powerful resources for studying survival outcomes. However, institutional retrospective chart-review studies have been able to provide more insight on recurrence patterns, morbidity, and quality-of-life metrics, as well as more details of the treatment information that may affect outcomes. This article discusses general considerations for understanding reported outcome data, summarizes the overall outcomes and their determinants, and provides histology-specific outcomes reported in the literature.
Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
Suat
S
Kilic
Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
Sarah S
SS
Kilic
Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
Soly
S
Baredes
Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA; Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA.
James K
JK
Liu
Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA; Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA; Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, 07103, USA. Electronic address: jean.anderson.eloy@gmail.com.
Jean Anderson
JA
Eloy
D004724:Endoscopy / Q000379:methods; D006801:Humans; D009017:Morbidity; D009296:Nasal Cavity / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000628:therapy*; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant / Q000379:methods; D019291:Skull Base / Q000473:pathology*; D019292:Skull Base Neoplasms / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome
Anterior skull base malignancy; Nasal cavity; Outcomes; Paranasal sinus; Sinonasal cancer; Sinonasal malignancy; Survival; Ventral skull base malignancy