Can pan-allergens affect the sensitization pattern?
The present study tested the hypothesis that a pan-allergen sensitization may affect the sensitization pattern. For this reason, 22 sensitization pattern allergens (SPA), common in Genoa (Italy), were selected for analyses. Successively, five of them, such as Pru p 3 as representative for LTP family, Bet v 1 and Pru p 1 for PR-10, and Bet v 2 and Pru p 4 for Profilin, were used as target allergens (TA). This retrospective study included 1059 subjects, (396 males and 663 females, mean age 42.8 years). The current study showed that sensitization to a pan-allergen entails higher odds to have other sensitizations. In addition, the co-sensitization pattern depends on the basis of the sensitizing pan-allergen family. LTP-sensitization is strongly associated with peanut sensitization, PR10 and profiling sensitization with hazelnut positivity. This study shows that a pan-allergen sensitization is frequently associated with co-sensitizations and the sensitization pattern depends on the sensitizing pan-allergen.
Internal Medicine Department, IRCCS-AOU San Martino-IST, Genoa, Italy. Electronic address: gio.cip@libero.it.
Giorgio
G
Ciprandi
Laboratory Medicine, IRCCS-AOU San Martino-IST, Genoa, Italy.
Paola
P
Comite
Clinical Epidemiology Unit, IRCCS-AOU San Martino-IST, Genoa, Italy.
Marco
M
Bruzzone
Clinical Epidemiology Unit, IRCCS-AOU San Martino-IST, Genoa, Italy.
Vincenzo
V
Fontana
D000328:Adult; D000485:Allergens / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D052179:Antigens, Plant / Q000276:immunology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D055815:Young Adult
D000485:Allergens; D052179:Antigens, Plant; D007073:Immunoglobulin E
Allergen-specific IgE; Genoa; Pan-allergen; Sensitization; Serum