The host cell response to tick-borne encephalitis virus.
Tick-borne encephalitis virus is the most prevalent autochthonous arbovirus in Europe and an important travel-associated virus. Complications of the infection could lead to lethal encephalitis in susceptible individuals. However, despite its clinical relevance and expanding geographical distribution, most of our knowledge on its pathogenesis is inferred from studies on other flaviviruses. Molecular details of the host cell response to infection are scarce leading to a poor understanding of the antiviral pathways and viral countermeasures that are critical to determine the outcome of the infection. In this work the relevant literature is reviewed and the key elements of tick-borne encephalitis virus infection of human cells are identified, which requires further investigation.
Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Tea
T
Carletti
Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Mohammad Khalid
MK
Zakaria
Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy. Electronic address: marcello@icgeb.org.
Alessandro
A
Marcello
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000821:virology*; D004669:Encephalitis Viruses, Tick-Borne / Q000472:pathogenicity / Q000502:physiology*; D004675:Encephalitis, Tick-Borne / Q000473:pathology* / Q000821:virology*; D018177:Flavivirus Infections / Q000821:virology*; D006801:Humans; D008954:Models, Biological; D014779:Virus Replication / Q000502:physiology
Flavivirus; Integrated stress response; Interferon; TBEV; Unfolded protein response