Antibacterial Activity and Bonding Ability of an Orthodontic Adhesive Containing the Antibacterial Monomer 2-Methacryloxylethyl Hexadecyl Methyl Ammonium Bromide.
Irreversible white spot lesion (WSL) occurs in up to 50% of patients during orthodontic treatment. Therefore, orthodontic adhesives need to be able to inhibit or reduce bacterial growth in order to prevent or minimize WSL. This study evaluated the antibacterial effect and shear bond strength (SBS) of a resin-based orthodontic adhesive containing the antibacterial monomer 2-methacryloxylethyl hexadecyl methyl ammonium bromide (MAE-HB). MAE-HB was added at three concentrations (1, 3, and 5 wt%) to a commercial orthodontic adhesive Transbond XT, while the blank control comprised unmodified Transbond XT. Their antibacterial effects on Streptococcus mutans were investigated after 0 and 180 days of aging. The SBS of metal brackets bonded to the buccal enamel surface of human premolars was assessed. Compared with the blank control, the MAE-HB-incorporated adhesive exhibited a significant contact inhibitory effect on the growth of S. mutans (P < 0.05), even after 180 days of aging. SBS and adhesive remnant index values revealed that the bonding ability of the experimental adhesive was not significantly adversely affected by the incorporation of MAE-HB at any of the three concentrations. Therefore, orthodontic adhesives with strong and long-lasting bacteriostatic properties can be created through the incorporation of MAE-HB without negatively influencing bonding ability.
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Fan
F
Yu
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Yan
Y
Dong
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Hao-Han
HH
Yu
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Ping-Ting
PT
Lin
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Ling
L
Zhang
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of VIP Dental Care, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Xiang
X
Sun
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Yan
Y
Liu
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Yu-Ning
YN
Xia
State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases &Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, China.
Li
L
Huang
State Key Laboratory of Military Stomatology &National Clinical Research Centre for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Ji-Hua
JH
Chen
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D003738:Dental Cements / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008689:Methacrylates / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D033081:Shear Strength; D013295:Streptococcus mutans / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure
C560117:2-methacryloxylethyl hexadecyl methyl ammonium bromide; D000900:Anti-Bacterial Agents; D003738:Dental Cements; D008689:Methacrylates; D000644:Quaternary Ammonium Compounds