HO-2 Pockets Myristoylated Gag.
Membrane binding of viral and cellular N-myristoylated proteins can be regulated by selectively sequestering myristate. In this issue of Cell Host & Microbe, Zhu et al. (2017) report on a myristate binding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myristoylated protein function.
Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA. Electronic address: reshm@mskcc.org.
Marilyn D
MD
Resh
D001665:Binding Sites; D008565:Membrane Proteins
D008565:Membrane Proteins