Potential Predictive Role of MicroRNAs in the Neoadjuvant Treatment of Esophageal Cancer.
Esophageal cancer is a disease with disappointing prognosis. Currently, there are no predictive factors that can identify patients who on the one hand would likely benefit from tri-modality management and, on the other hand, would not be significantly affected by the morbidity accompanying the treatment. MicroRNAs are short non-coding RNAs responsible for post-transcriptional modification of gene expression by binding to 3'-UTR of messenger RNA and represent emerging potential predictive biomarkers of treatment (chemotherapy and radiotherapy) efficacy and toxicity. We reviewed the current literature, addressing the potential predictive role of microRNAs for efficacy of chemotherapy (specifically cisplatin, 5-fluorouracil, doxorubicin and paclitaxel) and radiotherapy, including predicted targets in the cell. Altogether 82 articles were identified and included in this review. This may be the first review on this topic specifically focusing on neoadjuvant treatment of esophageal cancer.
Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.|Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, University Hospital in Olomouc, Olomouc, Czech Republic.
David
D
Vrana
Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic mmatzenauer@me.com.
Marcel
M
Matzenauer
Department of Surgery, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Rene
R
Aujesky
Department of Surgery, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Radek
R
Vrba
Department of Surgery, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Cestmir
C
Neoral
Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.|Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, University Hospital in Olomouc, Olomouc, Czech Republic.
Bohuslav
B
Melichar
Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic.
Pavel
P
Souček
D059186:Chemoradiotherapy, Adjuvant; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D011379:Prognosis
D035683:MicroRNAs
Esophageal cancer; chemotherapy; miRNA; microRNA; radiotherapy; review