Perinatal undernutrition associated to experimental model of cerebral palsy increases adverse effects on chewing in young rats.
The aim of the present study was to investigate the effect of perinatal undernutrition on the sensorimotor pattern of chewing in rats submitted to cerebral palsy experimental model. A total of 60 male Wistar rats were randomly distributed into four groups: Nourished/Control (NC, n=15), Nourished/Cerebral Palsy (NCP, n=15); Undernourished/Control (UC, n=15) and Undernourished/Cerebral Palsy (UCP, n=15). Animals of cerebral palsy (CP) group were subjected to an experimental model based on the combination of perinatal anoxia associated with sensorimotor restriction of the hindlimb. In the rats were evaluated body weight gain, intake of breast milk, feed post-weaning consumption, parameters of the chewing, intra-oral sensitivity and muscle properties (muscle weight and distribution of types of fibers) of the masseter and digastric. Animals from undernourished CP group showed greater reduction in most data evaluated including body weight (P<0.05), food intake post-weaning (P<0.05), frequency of chewing cycles (P<0.05), duration of the reactions of "taste" (P<0.05), muscle weight and decrease of the proportion of type IIB fibers in the masseter muscle (P<0.05). These results demonstrated in rats submitted a cerebral palsy that perinatal undernutrition intensifies the damage in morphological and functional parameters of chewing.
Post Graduate Program in Nutrition, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. Electronic address: diego.clacerda@hotmail.com.
Diego Cabral
DC
Lacerda
Department of Physical Education and Sports Science, CAV, Federal University of Pernambuco, 55608-680 Recife, PE, Brazil. Electronic address: kelliferraz@hotmail.com.
Kelli Nogueira
KN
Ferraz-Pereira
Post Graduate Program in Physical Therapy, Federal University of Pernambuco, 55608-680 Recife, PE, Brazil. Electronic address: diegovisco@gmail.com.
Diego Bulcão
DB
Visco
Post Graduate Program in Nutrition, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. Electronic address: brielle.pontes@hotmail.com.
Paula Brielle
PB
Pontes
Graduate in Nutrition, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. Electronic address: weniciusfchaves@gmail.com.
Wenicius Ferreira
WF
Chaves
Facultad de Químico-Farmacobiología, Universidad Michoacána de San Nicolás de Hidalgo, C. P. 58240 Morelia, Michoacán, Mexico. Electronic address: fn.nomore@gmail.com.
Omar
O
Guzman-Quevedo
Department of Nutrition, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. Electronic address: manhaesdecastroraul@gmail.com.
Raul
R
Manhães-de-Castro
Department of Nursing, CAV, Federal University of Pernambuco, 55608-680 Recife, PE, Brazil. Electronic address: aeltoscano@yahoo.com.br.
Ana Elisa
AE
Toscano
D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002547:Cerebral Palsy / Q000150:complications* / Q000209:etiology*; D004195:Disease Models, Animal; D020820:Dyskinesias / Q000209:etiology*; D005260:Female; D008297:Male; D044342:Malnutrition / Q000150:complications*; D008409:Mastication / Q000502:physiology*; D008895:Milk, Human / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats