Flow-Field Simulations and Hemolysis Estimates for the Food and Drug Administration Critical Path Initiative Centrifugal Blood Pump.
The design of blood pumps for use in ventricular assist devices, which provide life-saving circulatory support in patients with heart failure, require remarkable precision and attention to detail to replicate the functionality of the native heart. The United States Food and Drug Administration (FDA) initiated a Critical Path Initiative to standardize and facilitate the use of computational fluid dynamics in the study and development of these devices. As a part of the study, a simplified centrifugal blood pump model generated by computer-aided design was released to universities and laboratories nationwide. The effects of changes in fluid rheology due to temperature, hematocrit, and turbulent flow on key metrics of the FDA pump were examined in depth using results from a finite volume-based commercial computational fluid dynamics code. Differences in blood damage indices obtained using Eulerian and Lagrangian formulations were considered. These results are presented and discussed awaiting future validation using experimental results, which will be released by the FDA at a future date.
School of Chemical, Biological and Materials Engineering, University of Oklahoma.
Margaret L
ML
Heck
School of Chemical, Biological and Materials Engineering, University of Oklahoma.
Allen
A
Yen
School of Chemical, Biological and Materials Engineering, University of Oklahoma.|VADovations, Inc., 1333 Cornell Pkwy, Oklahoma City, OK, USA.
Trevor A
TA
Snyder
School of Chemical, Biological and Materials Engineering, University of Oklahoma.|Biomedical Engineering Center, University of Oklahoma, Norman, OK.
Edgar A
EA
O'Rear
School of Chemical, Biological and Materials Engineering, University of Oklahoma.
Dimitrios V
DV
Papavassiliou
D003198:Computer Simulation; D019091:Critical Pathways; D004867:Equipment Design; D004912:Erythrocytes / Q000473:pathology; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006400:Hematocrit; D006461:Hemolysis; D006801:Humans; D057446:Hydrodynamics; D008954:Models, Biological; D012212:Rheology; D013696:Temperature; D014481:United States; D014486:United States Food and Drug Administration
Blood pump; Computational fluid dynamics; Damage index estimates; Hemolysis; Ventricular assist device