A rapid screening platform for catalyst discovery in azide-alkyne cycloaddition by ICP-MS/MS.
We developed a rapid high-throughput screening platform using a modified ICP-MS/MS system for monovalence metal ions catalysts discovery in azide-alkyne cycloaddition. Among the ten monovalence metal ions in the first row of periodic table containing Sc+, Ti+, V+, Cr+, Mn+, Fe+, Co+, Ni+, Cu+, and Zn+, five monovalence metal ions of Sc+, Co+, Ni+, Cu+and Zn+ions show relatively stronger catalytic activities than others. The catalytic mechanism of Sc+, Co+and Ni+ions is similar to the Cu+ions, but Zn+ions take a different catalytic route. A yields range of 77-98% for azide-alkyne cycloaddition was achieved with Sc+, Co+, Ni+, Cu+and Zn+ions as catalyst, respectively by using a UV laser ablation reactor in 20min, notable that the yields of Co+and Sc+ions were even higher than the common catalyst of Cu+ions. The proposed platform would be used not only for catalyst discovery in azide-alkyne cycloaddition, but also for the discovery of single atom/ion catalysts in other organic reactions.
Department of Chemistry, Tsinghua University, Beijing 100084, China.
Qian
Q
He
Department of Physics, Tsinghua University, Beijing 100084, China.
Jia
J
Wang
Department of Physics, Tsinghua University, Beijing 100084, China.
Yuxiang
Y
Mo
National Institute of Metrology, Beijing 100029, China.
Chao
C
Wei
National Institute of Metrology, Beijing 100029, China.
Xiang
X
Fang
Department of Chemistry, Tsinghua University, Beijing 100084, China.
Zhi
Z
Xing
Department of Chemistry, Tsinghua University, Beijing 100084, China.
Sichun
S
Zhang
Department of Chemistry, Tsinghua University, Beijing 100084, China. Electronic address: xrzhang@mail.tsinghua.edu.cn.
Xinrong
X
Zhang
Azide–alkyne cycloaddition; Catalyst; High-throughput screening; ICP-MS/MS; Monovalence metal ions