Design of amphotericin B oral formulation for antifungal therapy.
Amphotericin B (AmB) remains the "gold standard" for systemic antifungal therapy, even though new drugs are emerging as the attractive antifungal agents. Since AmB has negligible oral absorption as a consequence of its unfavorable physicochemical characterizations, its use is restricted to parenteral administration which is accompanied by severe side effects. As greater understanding of the gastrointestinal tract has developed, the advanced drug delivery systems are emerging with the potential to overcome the barriers of AmB oral delivery. Much research has demonstrated that oral AmB formulations such as lipid formulations may have beneficial therapeutic efficacy with reduced adverse effects and suitable for clinical application. Here we reviewed the different formulation strategies to enhance oral drug efficacy, and discussed the current trends and future perspectives for AmB oral administration in the treatment of antifungal infections.
b Urology Department , First Affiliated Hospital of Gannan Medical University, Gannan Medical University , Ganzhou , China , and.
Min
M
Liu
c State Key Laboratory of Quality Research in Chinese Medicine , Institute of Chinese Medical Sciences, University of Macau , Macau , China.
Meiwan
M
Chen
a Department of Pharmacy , Songjiang Hospital Affiliated Shanghai First People's Hospital, Shanghai Jiao Tong University , Shanghai , China.
Zhiwen
Z
Yang
D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D004339:Drug Compounding; D016503:Drug Delivery Systems; D065569:Gastrointestinal Absorption; D006801:Humans; D008081:Liposomes; D012995:Solubility
D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B
Amphotericin B; formulation design; oral administration