The crosstalk between long non-coding RNAs and PI3K in cancer.
Long non-coding RNAs (lncRNAs) are able to positively or negatively regulate other genes expression in cis or in trans. Their effect can be achieved through RNA-protein, RNA-DNA, or RNA-RNA interactions. They can recruit transcription factors and act as scaffolds or guides for chromatin-modifying enzymes. PI3K kinases transform external stimuli to intracellular signals regulating cell growth, differentiation, proliferation, survival, intracellular trafficking, cytoskeletal changes, cell migration and motility, and metabolism. PI3K is activated in cancer and affects several aspects of oncogenesis. LncRNAs and PI3K have been shown to be interconnected in several different cancer subtypes enhancing aberrant cell proliferation, epithelial-to-mesenchymal transition, migration and invasion, and also cancer cell metabolism. In this review, we have assembled recent data describing the interaction between lncRNAs and PI3K and the results of such interaction.
Blood Bank, Preveza General Hospital, Selefkeias 2, 48100, Preveza, Greece. benetatosleon@yahoo.com.
Leonidas
L
Benetatos
Department of Medical Oncology, 424 Military Hospital, Thessaloniki, Greece.
Evangelos
E
Voulgaris
Molecular Biology Laboratory, Ioannina University Hospital, Ioannina, Greece.
Georgios
G
Vartholomatos
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D022661:RNA, Untranslated / Q000378:metabolism*
D022661:RNA, Untranslated; D019869:Phosphatidylinositol 3-Kinases
Cancer; Differentiation; Long non-coding RNAs; Metastasis; PI3K