[Rapid diagnostic test for malaria].
The rapid diagnostic tests (RDTs) whose main interest lies in their implementation without special equipment by unskilled personnel have grown significantly over the past fifteen years to diagnose malaria. They rely on the detection of specific Plasmodium proteins, PfHRP2, pLDH and aldolase. If the detection of PfHRP2 has very good sensitivity for the diagnosis of Plasmodium falciparum malaria, the detection of pLDH or aldolase is less efficient for other species, leaving its place to the reference microscopic diagnosis. RDT could not generally be used to monitor therapeutic efficacy because they can remain positive after clinical and parasitological cure. Furthermore, the development of the use of these tests has highlighted the need for quality assurance programs to monitor their production as their use.
Laboratoire de parasitologie-mycologie, CNR du paludisme, AP-HP, CHU Bichat-C Bernard, 46 rue Henri Huchard, 75018, Paris, France. sandrine.houze@bch.aphp.fr.
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D000953:Antigens, Protozoan / Q000032:analysis / Q000097:blood; D003955:Diagnostic Tests, Routine / Q000379:methods*; D006801:Humans; D008288:Malaria / Q000097:blood / Q000175:diagnosis*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013997:Time Factors
D000953:Antigens, Protozoan; D011933:Reagent Kits, Diagnostic
Antigen; Detection; Malaria; Quality assurance; RDT; Rapid Diagnostic Test