Metronidazole and Norfloxacin Induced Generalized Fixed Drug Eruptions in an Adult Male Patient - a Case Report.
BACKGROUND
Fluoroquinolones are most widely used for empirical treatment of gastrointestinal disease due to emergence of drug resistant strains to other antimicrobials. They are also indulged in cutaneous adverse drug reactions with varying form of severity.


METHODS
A 43 year old male patient developed fixed drug eruptions after administration of tablet norfloxacin and metronidazole for the treatment of colicky abdominal pain with diarrhoea. Erythematous rashes involved whole body including buccal mucosa. Causative drugs were stopped and patient was managed by local as well as systemic therapy and was recovered after 20 days.


CONCLUSIONS
Awareness among healthcare professionals regarding FDEs and its management is essential to prevent mortality and morbidity and counsel patient regarding future use of drugs causing reactions with physician's advice.
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001, Gujarat,India.
Nidhi S
NS
Patel
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001, Gujarat,India.
Bhavesh C
BC
Chavada
CM 31/13, Shantinagar 2, Near Bhagwati Circle, Kalvibid, Bhavnagar-364002, Gujarat,India.
Viren N
VN
Naik
Employee's State Insurance Corporation (ESIC) Hospital, Bhavnagar-364001, Gujarat,India.
Hiteshkumar N
HN
Patel
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001, Gujarat,India.
C B
CB
Tripathi
D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000009:adverse effects / Q000008:administration & dosage; D000328:Adult; D008795:Metronidazole / Q000009:adverse effects / Q000008:administration & dosage; D003875:Drug Eruptions / Q000209:etiology / Q000175:diagnosis; D000900:Anti-Bacterial Agents / Q000009:adverse effects
D009643:Norfloxacin; D008795:Metronidazole; D000900:Anti-Bacterial Agents
Cross sensitivity; FDE.; empirical treatment; fixed drug eruptions; metronidazole; norfloxacin