Adenoid cystic carcinoma of the base of tongue: A population-based study.
BACKGROUND
The objective was to assess demographic and survival patterns in patients with adenoid cystic carcinoma of the base of tongue.


METHODS
Patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1973 through 2012 and were categorized by age, gender, race, historical stage A, and treatment. Incidence and survival were compared with Kaplan Meier curves and mortality hazard ratios.


RESULTS
A total of 216 patients were included. After adjusting for age, gender, race and tumor-directed treatment, patients over the age of 70years had a significantly increased mortality [HR=2.847, 95% CI (1.499, 5.404) p=0.0014]. Furthermore mortality among patients with distant disease was significantly increased [HR=2.474 95% CI (1.459, 4.195) p=0.00008].


CONCLUSIONS
By examining the largest collection of patients we have demonstrated that there is a significant difference in mortality based on both the age at diagnosis and in the setting of distant disease.
Department of Otolaryngology, Head & Neck and Skull Base Surgery, Boston Medical Center, Boston, MA, United States.
Diana N
DN
Kirke
Maulana Azad Medical College, New Delhi, Delhi, India.
Chandala
C
Chitguppi
Department of Otolaryngology, Head & Neck and Skull Base Surgery, Boston Medical Center, Boston, MA, United States.
Samuel J
SJ
Rubin
Department of Radiation Oncology, Boston Medical Center, Boston, MA, United States.
Minh T
MT
Truong
Department of Otolaryngology, Head & Neck and Skull Base Surgery, Boston Medical Center, Boston, MA, United States. Electronic address: Scharukh.Jalisi@bmc.org.
Scharukh
S
Jalisi
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011159:Population Surveillance / Q000379:methods*; D012042:Registries; D012189:Retrospective Studies; D018426:SEER Program; D017678:Sex Distribution; D015996:Survival Rate / Q000639:trends; D014059:Tongue / Q000473:pathology*; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
Adenoid cystic; Base of tongue; Cancer; Oropharynx; Seer