Treatment of Infections Caused by Rhodococcus equi.
Pneumonia caused by Rhodococcus equi remains an important cause of disease and death in foals. The combination of a macrolide (erythromycin, azithromycin, or clarithromycin) with rifampin remains the recommended therapy for foals with clinical signs of infection caused by R equi. Most foals with small, subclinical ultrasonographic pulmonary lesions associated with R equi recover without therapy, and administration of antimicrobial agents to these subclinically affected foals does not hasten lesion resolution relative to administration of a placebo. Resistance to macrolides and rifampin in isolates of R equi is increasing.
Department of Large Animal Medicine, Veterinary Medical Center, University of Georgia, Athens GA 30605. Electronic address: gigueres@uga.edu.
Steeve
S
Giguère
D000193:Actinomycetales Infections / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use; D017291:Clarithromycin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D004917:Erythromycin / Q000627:therapeutic use; D006734:Horse Diseases / Q000188:drug therapy* / Q000382:microbiology*; D006736:Horses; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D016929:Rhodococcus equi / Q000302:isolation & purification*; D012293:Rifampin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin; D012293:Rifampin
Macrolide; Pneumonia; Rhodococcus equi; Rifampin