Prognostic value of nocturnal hypoventilation in neuromuscular patients.
In neuromuscular disease (NMD) patients, current guidelines recommend the initiation of home mechanical ventilation (HMV) in case of daytime hypercapnia or nocturnal desaturation as an indirect sign of hypoventilation. Transcutaneous capno-oximetry (TcCO2) enables the direct assessment of nocturnal hypercapnia; however the best cut-off value remains to be defined. We aimed to compare the prognostic value of several published definitions of nocturnal hypercapnia in a cohort of NMD patients. All consecutive TcCO2recordings performed between 2010 and 2014 in unventilated adult NMD patients in a tertiary reference centre were retrospectively collected. Initiation of HMV and mortality were collected as outcomes of interest. 124 patients with normal daytime blood gazes were analysed (median age 39 [IQR 31-55] years; vital capacity 61% [43-82] of predicted). The prevalence of nocturnal hypercapnia ranged from 3% to 44%, depending on the definition. Over a median follow-up duration of 2.5 years [IQR 1.6-4.1], HMV was initiated for 51 patients, whilst 4 patients died. Nocturnal peak TcCO2≥49 mmHg was the best predictor of HMV initiation in the follow-up, being associated with a hazard ratio of 2.6 [95% CI 1.4-4.6] in a multivariate analysis adjusting for lung function parameters. Nocturnal TcCO2identifies NMD patients at risk for subsequent need for HMV in the following few years, who were not identified by daytime blood gases or nocturnal oximetry. As a consequence, peak nocturnal TcCO2≥49 mmHg should be considered as one of the criteria to start HMV in patients with NMDs, along with symptoms of hypoventilation, daytime hypercapnia, abnormal nocturnal oximetry results, and a diminished level of forced vital capacity.
Service de Réanimation médicale et unité de ventilation à domicile, CHU Raymond Poincaré, 92380 Garches, France; INSERM CIC 14.29, CHU Raymond Poincaré, 92380 Garches, France.
David
D
Orlikowski
Service de Physiologie-Explorations Fonctionnelles, CHU Raymond Poincaré, 92380 Garches, France.
Helene
H
Prigent
Unité du Sommeil, CHU Raymond Poincaré, 92380 Garches, France.
Maria-Antonia
MA
Quera Salva
Service de Réanimation médicale et unité de ventilation à domicile, CHU Raymond Poincaré, 92380 Garches, France.
Nicholas
N
Heming
Service de Biostatistique et Information Médicale, CHU Saint Louis, 75475 Paris, France.
Cendrine
C
Chaffaut
Service de Biostatistique et Information Médicale, CHU Saint Louis, 75475 Paris, France.
Sylvie
S
Chevret
Service de Réanimation médicale et unité de ventilation à domicile, CHU Raymond Poincaré, 92380 Garches, France.
Djillali
D
Annane
Service de Physiologie-Explorations Fonctionnelles, CHU Raymond Poincaré, 92380 Garches, France; Unité du Sommeil, CHU Raymond Poincaré, 92380 Garches, France.
Frederic
F
Lofaso
Service de Réanimation médicale et unité de ventilation à domicile, CHU Raymond Poincaré, 92380 Garches, France; INSERM CIC 14.29, CHU Raymond Poincaré, 92380 Garches, France. Electronic address: adam.ogna@aphp.fr.
Adam
A
Ogna
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006935:Hypercapnia / Q000175:diagnosis* / Q000209:etiology; D007040:Hypoventilation / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D011379:Prognosis; D012121:Respiration, Artificial
Home mechanical ventilation; Neuromuscular disease; Nocturnal hypoventilation; Restrictive respiratory failure; Transcutaneous capno-oximetry