Long-term follow-up of Dupuytren disease after injection of triamcinolone acetonide in Chinese patients in Taiwan.
Injection of triamcinolone acetonide is a non-operative treatment for early-stage Dupuytren disease in Caucasians, but its effectiveness in non-Caucasians is unclear. We report averaged 5-year follow-up results of 37 patients (49 affected hands) with early-stage Dupuytren disease for patients in Taiwan (non-Caucasian) who received a single dose of 5 mg triamcinolone acetonide injection into nodules monthly for 3 months. Using ultrasound, we recorded no progression of sizes of the modules following injection after 6 months. After an average 5-year follow-up, two patients with three hands (6%) experienced reactivation of the treated nodules. None required surgical intervention. Ultrasound examination showed that sizes of the treated Dupuytren nodules decreased significantly by 40% 6 months after injection and 56% at the final follow-up. We conclude that in these Chinese patients in Taiwan with early Dupuytren nodules, triamcinolone acetonide injection was effective in reducing the size of the Dupuytren nodules and maintaining long-term durable control of the nodular growth.


METHODS
III.
2 Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
C-Y
CY
Yin
3 Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
H-H M
HM
Yu
1 School of Medicine, National Yang-Ming University, Taipei, Taiwan.|2 Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
J-P
JP
Wang
1 School of Medicine, National Yang-Ming University, Taipei, Taiwan.|2 Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Y-C
YC
Huang
1 School of Medicine, National Yang-Ming University, Taipei, Taiwan.|2 Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
T-F
TF
Huang
1 School of Medicine, National Yang-Ming University, Taipei, Taiwan.|2 Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
M-C
MC
Chang
D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D018450:Disease Progression; D004387:Dupuytren Contracture / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D013624:Taiwan; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014463:Ultrasonography
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide
Dupuytren’s disease; ethnicity; triamcinolone acetonide; ultrasound