One Cycle Fuels Another: The Energetics of Neurotransmitter Release.
In this issue of Neuron, Ashrafi et al. (2017) show that activity induces translocation of the insulin-regulated glucose transporter GLUT4 to the plasma membrane, where it sustains the ATP production required for synaptic vesicle cycling. However, translocation occurs from presynaptic membranes other than synaptic vesicles and involves a distinct molecular mechanism.
Kavli Institute for Fundamental Neuroscience, UCSF Weill Institute for Neurosciences, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA; Departments of Neurology and Physiology, UCSF School of Medicine, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA.
Katlin
K
Silm
Kavli Institute for Fundamental Neuroscience, UCSF Weill Institute for Neurosciences, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA; Departments of Neurology and Physiology, UCSF School of Medicine, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA. Electronic address: robert.edwards@ucsf.edu.
Robert H
RH
Edwards
D001692:Biological Transport; D002462:Cell Membrane; D051275:Glucose Transporter Type 4; D007328:Insulin; D009124:Muscle Proteins; D018377:Neurotransmitter Agents; D013572:Synaptic Vesicles
D051275:Glucose Transporter Type 4; D007328:Insulin; D009124:Muscle Proteins; D018377:Neurotransmitter Agents