The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives.
More than ten years after the initial description of the humoral theory of transplantation by Dr. Paul I. Terasaki, the significance of humoral alloimmunity in liver transplantation has yet to be clearly defined. The liver allograft has an inherent tolerogenic capacity which confers its resistance to cell-mediated as well as antibody-mediated rejection. Nevertheless, the protection against alloimmunity is not complete, and antibody-mediated tissue injury can occur in the liver graft under specific circumstances. In this article the evidence on the clinicopathologic effects of donor-specific alloantibodies in liver transplantation will be examined and interpreted in parallel with lessons learned from renal transplantation. The unique anatomic and immunologic features of the liver will be reviewed to gain new insights into the complex interactions between humoral immune system and the liver allograft.
Terasaki Foundation Laboratory, Los Angeles, CA, USA; Division of Liver and Pancreas Transplantation, Department of Surgery, University of California, Los Angeles, CA, USA.
Elaine Y
0000-0002-8362-223X
EY
Cheng
D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D056724:Immunity, Humoral / Q000276:immunology*; D007165:Immunosuppression Therapy; D007518:Isoantibodies / Q000276:immunology*; D016030:Kidney Transplantation; D008099:Liver / Q000276:immunology / Q000601:surgery; D016031:Liver Transplantation
D007518:Isoantibodies