Association of red cell distribution width with noninfarct-related artery-chronic total occlusion in acute myocardial infarction patients.
OBJECTIVE
The presence of chronic total occlusion (CTO) in noninfarct-related artery (non-IRA) is an independent predictor of mortality in acute myocardial infarction (AMI). We investigated whether red cell distribution width (RDW) levels are associated with presence of non-IRA-CTO in AMI (ST-elevation myocardial infarction [STEMI] and non-STEMI).


METHODS
Patients (n = 858) were categorized into three groups: single vessel disease, multivessel disease (MVD) without CTO and MVD with CTO.


RESULTS
MVD with CTO group had higher RDW levels than single vessel disease and MVD without CTO groups (14.87 ± 1.09% vs 13.82 ± 1.01% and 13.87 ± 0.87%, respectively, p < 0.001). In-hospital mortality was also higher in patients with MVD with CTO (p < 0.001). On multivariate analysis, RDW (odds ratio [OR]: 1.761; p < 0.001), age (OR: 1.04; p < 0.001), creatinine (OR: 3.524; p = 0.027), current smoker (OR: 0.489; p = 0.022), hemoglobin (OR: 0.826; p = 0.044), and non-STEMI (OR: 3.065; p < 0.001) were predictors of occurrence of non-IRA-CTO.


CONCLUSIONS
Increased RDW is independently associated with presence of non-IRA-CTO in AMI patients.
Department of Cardiology, Ankara Education & Research Hospital, Ankara, Turkey.
Mikail
M
Yarlioglues
Department of Cardiology, Ankara Education & Research Hospital, Ankara, Turkey.
Alparslan
A
Kurtul
D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D019540:Area Under Curve; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000166:cytology* / Q000502:physiology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000401:mortality / Q000473:pathology*; D016017:Odds Ratio; D012372:ROC Curve; D012907:Smoking
D006454:Hemoglobins; D003404:Creatinine
acute myocardial infarction; chronic total occlusion; red cell distribution width