Classics in Chemical Neuroscience: Haloperidol.
The discovery of haloperidol catalyzed a breakthrough in our understanding of the biochemical basis of schizophrenia, improved the treatment of psychosis, and facilitated deinstitutionalization. In doing so, it solidified the role for chemical neuroscience as a means to elucidate the molecular underpinnings of complex neuropsychiatric disorders. In this Review, we will cover aspects of haloperidol's synthesis, manufacturing, metabolism, pharmacology, approved and off-label indications, and adverse effects. We will also convey the fascinating history of this classic molecule and the influence that it has had on the evolution of neuropsychopharmacology and neuroscience.
Chemical Neurobiology Laboratory, Center for Genomic Medicine, Chemical Biology Program, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts 02114, United States.
Marshall W
0000-0001-5401-3104
MW
Tyler
Chemical Neurobiology Laboratory, Center for Genomic Medicine, Chemical Biology Program, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts 02114, United States.|Centro de Investigaciones Biológicas-CSIC , Madrid 28040, Spain.
Josefa
J
Zaldivar-Diez
Chemical Neurobiology Laboratory, Center for Genomic Medicine, Chemical Biology Program, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts 02114, United States.
Stephen J
SJ
Haggarty
D000818:Animals; D014150:Antipsychotic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D006220:Haloperidol / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009488:Neurosciences
D014150:Antipsychotic Agents; D006220:Haloperidol
Haloperidol; antipsychotic; dopamine; history; pharmacology; schizophrenia