Live attenuated influenza vaccine effectiveness against hospitalisation due to laboratory-confirmed influenza in children two to six years of age in England in the 2015/16 season.
The United Kingdom is introducing a universal annual influenza vaccination programme for children. Live attenuated influenza vaccine (LAIV) effectiveness (VE) against laboratory-confirmed influenza hospitalisation in 2 to 6 year-olds in England was measured in 2015/16 using the screening method. VE adjusted for age, geography and month was 54.5% (95% confidence interval (CI): 31.5% to 68.4%) for all influenza types combined; 48.3% (95% CI: 16.9% to 67.8%) for A(H1N1)pdm09 and 70.6% (95% CI: 33.2% to 87.1%) for B. The findings support on-going programme roll-out.
National Infection Service, Public Health England, London, United Kingdom.
Richard
R
Pebody
National Infection Service, Public Health England, London, United Kingdom.
Bersabeh
B
Sile
National Infection Service, Public Health England, London, United Kingdom.
Fiona
F
Warburton
National Infection Service, Public Health England, London, United Kingdom.
Mary
M
Sinnathamby
National Infection Service, Public Health England, London, United Kingdom.
Camille
C
Tsang
National Infection Service, Public Health England, London, United Kingdom.
Hongxin
H
Zhao
National Infection Service, Public Health England, London, United Kingdom.
Joanna
J
Ellis
National Infection Service, Public Health England, London, United Kingdom.
Nick
N
Andrews
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000517:prevention & control*; D004739:England / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D017589:Immunization Programs; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology / Q000302:isolation & purification*; D009981:Influenza B virus / Q000276:immunology / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D007753:Laboratories; D008297:Male; D017063:Outcome Assessment, Health Care; D012621:Seasons; D014611:Vaccination / Q000706:statistics & numerical data; D064166:Vaccine Potency; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology*
D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
LAIV; hospitalisation; influenza; vaccine effectiveness