Non-antibiotic approaches at drying-off for treating and preventing intramammary infections: a protocol for a systematic review and meta-analysis.
Intramammary infection (IMI) treatment and prevention at drying-off is one of the leading causes for using antimicrobials on dairy farms. The objective of the current paper is to describe the protocol used for conducting a systematic review of the literature on non-antibiotic strategies that can be used on dairy cows at dry off to treat and prevent IMI. Relevant literature will be identified using a combination of database search strategies and iterative screening of references. To be included in the review, articles will have to: (1) be published after 1969; (2) be written in English, French, or Spanish; (3) use a study design such as a controlled trial, an observational study, or an experimental study conducted in vivo; (4) be conducted on commercial dairy cows; (5) investigate a non-antibiotic intervention used at dry off; and finally, (6) report on a relevant mastitis outcome. Titles and abstracts, then full articles will be reviewed for inclusion. Specific data will be extracted and risk of bias will be assessed for all included articles. The planned systematic review will be the first to colligate, in a coherent whole, studies investigating non-antibiotic strategies for treating and preventing IMI at drying-off.
Département de sciences cliniques,Faculté de médecine vétérinaire,Université de Montréal,C.P. 5000,St-Hyacinthe,QC, J2S 7C6,Canada.
David
D
Francoz
Département de sciences cliniques,Faculté de médecine vétérinaire,Université de Montréal,C.P. 5000,St-Hyacinthe,QC, J2S 7C6,Canada.
Vincent
V
Wellemans
Département de sciences cliniques,Faculté de médecine vétérinaire,Université de Montréal,C.P. 5000,St-Hyacinthe,QC, J2S 7C6,Canada.
Jean-Philippe
JP
Roy
Canadian Bovine Mastitis and Milk Quality Research Network,C.P. 5000,St-Hyacinthe,QC, J2S 7C6,Canada.
Pierre
P
Lacasse
Département de sciences cliniques,Faculté de médecine vétérinaire,Université de Montréal,C.P. 5000,St-Hyacinthe,QC, J2S 7C6,Canada.
Alfredo
A
Ordonez-Iturriaga
Département de pathologie et microbiologie, Faculté de médecine vétérinaire,Université de Montréal,C.P. 5000,St-Hyacinthe,QC, J2S 7C6,Canada.
François
F
Labelle
Canadian Bovine Mastitis and Milk Quality Research Network,C.P. 5000,St-Hyacinthe,QC, J2S 7C6,Canada.
Simon
S
Dufour
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002417:Cattle; D005260:Female; D007774:Lactation / Q000502:physiology*; D008321:Mammary Glands, Animal / Q000382:microbiology / Q000502:physiology*; D008414:Mastitis, Bovine / Q000188:drug therapy / Q000517:prevention & control*; D000078202:Systematic Reviews as Topic; D015201:Meta-Analysis as Topic
D000900:Anti-Bacterial Agents
dairy cows; dry off; intramammary infection; systematic review; treatment