Lipid Metabolism Fuels Cancer's Spread.
The ability to prospectively identify metastasis-initiating cells is essential for developing new anti-metastasis therapeutics. In a recent issue of Nature, Pascual et al. (2017) demonstrate that the fatty acid receptor CD36 marks a subpopulation of cancer cells with unique metastasis-initiating potential, highlighting a key role of lipid metabolism in metastatic colonization.
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Zhuo
Z
Li
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: ykang@princeton.edu.
Yibin
Y
Kang
D002352:Carrier Proteins; D005227:Fatty Acids; D006801:Humans; D050356:Lipid Metabolism; D009369:Neoplasms
D002352:Carrier Proteins; D005227:Fatty Acids