Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria.
A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50value of 0.61 μM, being comparable to that of the positive control orlistat (IC50= 0.78 μM).
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.|b University of Chinese Academy of Sciences , Beijing 100049 , China.
Min
M
Yang
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.|c College of Material Science and Engineering, Central South University of Forestry and Technology , Changsha 410004 , China.
Lin-Fu
LF
Liang
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
Ting
T
Wang
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
He-Yao
HY
Wang
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
Hai-Li
HL
Liu
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
Yue-Wei
YW
Guo
D000818:Animals; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047131:Xestospongia / Q000737:chemistry*
D006842:Hydrocarbons, Brominated; C000621768:xestonariene I; D053279:Polyynes; D008049:Lipase
Brominated polyacetylene; Xestospongia testudinaria; pancreatic lipase inhibitory activity; sponge