Human Papillomavirus-Associated Neoplasms of the Head and Neck.
Human papillomavirus (HPV) is an essential causal factor in a subset of head and neck neoplasms, most notably oropharyngeal squamous cell carcinoma, for which HPV infection has important diagnostic, prognostic, and therapeutic implications. This article summarizes the current understanding of HPV-associated neoplasms of the head and neck, including the recently described carcinoma with adenoid cystic-like features. Salient clinical, gross, and microscopic features are discussed, and the utility of specific ancillary studies is highlighted.
Department of Pathology, University of Michigan Health System, 2G309 UH, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5054, USA.
Aaron M
AM
Udager
Department of Pathology, University of Michigan Health System, 2G332 UH, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5054, USA. Electronic address: jonamch@umich.edu.
Jonathan B
JB
McHugh
D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D003937:Diagnosis, Differential; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
Carcinoma with adenoid cystic-like features; Nasopharyngeal carcinoma; Oropharynx; Sinonasal (Schneiderian) papilloma; Squamous cell carcinoma