A Multicenter Randomized Controlled Study of Antioxidant Supplementation with Lutein for Chronic Central Serous Chorioretinopathy.
OBJECTIVE
To investigate functional and morphological changes in patients with chronic central serous chorioretinopathy after supplementation with antioxidants containing lutein or a placebo.


METHODS
One hundred eyes of 100 patients were randomly divided into 2 groups, one taking tablets with lutein plus other antioxidants and the other taking a placebo for 6 months. Best-corrected visual acuity (BCVA) and the subfoveal fluid height on optical coherence tomography were measured.


RESULTS
Seventy-nine patients (37 in the supplementation and 42 in the placebo group) completed the 6-month follow-up. In the supplementation group, mean BCVA showed significant improvement (p = 0.003), while there was no significant change in the placebo group (p = 0.589). The mean subfoveal fluid height was significantly reduced, by 28.6%, in the supplementation group (p = 0.028), in contrast to 3.3% in the placebo group (p = 0.898).


CONCLUSIONS
Antioxidant supplementation significantly reduced subfoveal fluid height. The impacts of antioxidant supplementation on BCVA remain to be elucidated in future studies.
Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
Ari
A
Shinojima
Miki
M
Sawa
Tetsuju
T
Sekiryu
Yuji
Y
Oshima
Ryusaburo
R
Mori
Chikako
C
Hara
Yukinori
Y
Sugano
Aki
A
Kato
Hitomi
H
Asato
Mitsuko
M
Yuzawa
Fumi
F
Gomi
Yuichiro
Y
Ogura
Tatsuro
T
Ishibashi
Tomoaki
T
Nanri
Tsutomu
T
Yasukawa
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000178:diet therapy*; D002908:Chronic Disease; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D014975:Lutein / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity
D000975:Antioxidants; D014975:Lutein