Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea.
Antibiotic treatment alters the composition and metabolic function of the intestinal microbiota. These alterations may contribute to the pathogenesis of necrotizing enterocolitis (NEC) and antibiotic-associated diarrhea (AAD). Recent studies are beginning to unravel the contribution of specific groups of microbes and their metabolic pathways to these diseases. Probiotics or other microbiota-targeted therapies may provide effect strategies to prevent and treat NEC and AAD.
Division of Infectious Diseases, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: SILVERMAM1@EMAIL.CHOP.EDU.
Michael A
MA
Silverman
Department of Pediatric and Newborn Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Liza
L
Konnikova
Division of Infectious Diseases, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA.
Jeffrey S
JS
Gerber
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced* / Q000188:drug therapy / Q000382:microbiology; D064806:Dysbiosis / Q000139:chemically induced; D020345:Enterocolitis, Necrotizing / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D019936:Probiotics / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents
Antibiotic-associated diarrhea; Antibiotics; Clostridium difficile; Microbiome; Necrotizing enterocolitis; Probiotics