Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles.
A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Bing
B
Jiang
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Fei-Fan
FF
Meng
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Qiu-Ju
QJ
Liang
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Yun-He
0000-0001-8817-0626
YH
Xu
Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.|Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371.
Teck-Peng
0000-0002-2936-337X
TP
Loh