Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers.
Background:Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion.Objective:We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concentrations, hunger and satiety ratings, and food intake in healthy volunteers.Design:Lingual bitter taste sensitivity was tested with the use of 6 concentrations of DB in 65 subjects. A placebo or 1 μmol DB/kg was given intragastrically to assess its effect on fasting gastrointestinal motility and hunger ratings, motilin and ghrelin plasma concentrations, satiety, and caloric intake.Results:Women (n= 39) were more sensitive toward a lingual bitter stimulus (P= 0.005) than men (n= 26). In women (n= 10), intragastric DB switched the origin of phase III contractions from the stomach to the duodenum (P= 0.001) and decreased hunger ratings (P= 0.04). These effects were not observed in men (n= 10). In women (n= 12), motilin (P= 0.04) plasma concentrations decreased after intragastric DB administration, whereas total and octanoylated ghrelin were not affected. The intragastric administration of DB decreased hunger (P= 0.008) and increased satiety ratings (P= 0.01) after a meal (500 kcal) in 13 women without affecting gastric emptying in 6 women. Caloric intake tended to decrease after DB administration compared with the placebo (mean ± SEM: 720 ± 58 compared with 796 ± 45 kcal;P= 0.08) in 20 women.Conclusions:Intragastric DB administration decreases both antral motility and hunger ratings during the fasting state, possibly because of a decrease in motilin release. Moreover, DB decreases hunger and increases satiety ratings after a meal and shows potential for decreasing caloric intake. This trial was registered at clinicaltrials.gov as NCT02759926.
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.
Eveline
0000-0001-8694-7745
E
Deloose
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.
Pieter
P
Janssen
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.|National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals National Health Service Trust, University of Nottingham, Nottingham, United Kingdom.
Maura
M
Corsetti
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.
Jessica
J
Biesiekierski
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.
Imke
I
Masuy
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.
Alessandra
A
Rotondo
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.
Lukas
L
Van Oudenhove
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and.
Inge
I
Depoortere
Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium; and jan.tack@kuleuven.be.
Jan
J
Tack
D000328:Adult; D004063:Digestion; D004386:Duodenum / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects*; D005215:Fasting; D005260:Female; D005746:Gastric Emptying; D005769:Gastrointestinal Motility / Q000187:drug effects*; D054439:Ghrelin / Q000097:blood; D064368:Healthy Volunteers; D006801:Humans; D006815:Hunger / Q000187:drug effects*; D008297:Male; D062407:Meals; D009037:Motilin / Q000097:blood; D010528:Peristalsis / Q000187:drug effects; D019518:Postprandial Period; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D012528:Satiety Response / Q000187:drug effects*; D012737:Sex Factors; D013270:Stomach / Q000187:drug effects*; D013649:Taste; D055815:Young Adult
D054439:Ghrelin; D009037:Motilin; D000644:Quaternary Ammonium Compounds; C043414:denatonium
bitter; denatonium benzoate; hunger; migrating motor complex; motilin