title: Polyglycolic acid sheet attached with fibrin glue can facilitate faster epithelialization of the mastoid cavity after canal wall-down tympanoplasty.
abstract: OBJECTIVE
  This study retrospectively investigated whether polyglycolic acid (PGA) sheet attached to the bone surface using fibrin glue facilitate faster epithelialization of the mastoid bowl after canal wall-down (CWD) tympanoplasty compared to a simple dressing using poly-N-acetyl-glucosamine (Kichin) sheet.
  
  
  METHODS
  After completion of the CWD tympanoplasty, PGA sheet (n=16, PGA group) with fibrin glue or Kichin sheet (n=38, Kichin group) were placed on the bone surface of the mastoid bowl.
  
  
  RESULTS
  Postoperative epithelialization of the mastoid cavity was significantly (p<0.05) faster in the PGA group than in the Kichin group (mean 135 versus 244 days, respectively). Use of the Kaplan-Meier method showed that only the short-term epithelialization rate (up to 100 days after operation) was significantly higher. No major adverse effects related to either procedure were seen.
  
  
  CONCLUSIONS
  Epithelialization of the mastoid bowl after CWD tympanoplasty was faster in the postoperative short term when it was dressed with PGA sheet using fibrin glue compared with Kichin sheet.
authors.affiliation: Department of Otolaryngology, Kochi Medical School Oko-cho, Nankoku-shi, Kochi, 780-8505, Japan. Electronic address: tkobayashi@kochi-u.ac.jp.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Department of Otolaryngology, Takanoko Hospital 525-1, Takanoko-cho, Matsuyama-shi, Ehime, 790-0925, Japan.
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Gyo
authors.affiliation: Department of Otolaryngology, Kochi Medical School Oko-cho, Nankoku-shi, Kochi, 780-8505, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Komori
authors.affiliation: Department of Otolaryngology, Kochi Medical School Oko-cho, Nankoku-shi, Kochi, 780-8505, Japan.
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Hyodo
mesh_terms: D018424:Cholesteatoma, Middle Ear / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008416:Mastoid / Q000601:surgery*; D008875:Middle Aged; D011100:Polyglycolic Acid / Q000627:therapeutic use*; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D062326:Re-Epithelialization; D012189:Retrospective Studies; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use; D016896:Treatment Outcome; D014433:Tympanoplasty / Q000379:methods*
chemical_list: D015718:Fibrin Tissue Adhesive; D011135:Polysaccharides, Bacterial; D014014:Tissue Adhesives; C113579:polysaccharide intercellular adhesin; D011100:Polyglycolic Acid
keywords: Cavity problem; Dressing material; Healing of the opened mastoid cavity; Middle-ear cholesteatoma