title: Influence of Prognostic Factors for Recurrence of Adenocarcinoma of the Stomach.
abstract: BACKGROUND
  Gastric cancer is the second most important neoplasm in the world. Surgical resection is the treatment of choice for gastric cancer, and recognized by the International Union against Cancer (International Union Against Cancer - UICC) TNM classification of the parameters of the tumor and lymph node. Prognostic factors related to characteristics of the tumor by histopathologic findings have an impact on the planning of the operation. According to the results of most studies it is possible to predict survival and recurrence based on histological type and TNM classification of tumors on the one hand and the surgical procedure on the other.
  
  
  OBJECTIVE
  The aim of the research was to analyze prognostic factors that influenced the frequency of recurrence in gastric surgery patients.
  
  
  METHODS
  The five year study covered a population of 100 treated patients of adenocarcinoma of the stomach at the Department of Surgery, University Clinical Center Tuzla. The first group were characteristics of tumors in patients with gastric adenocarcinoma. Lymphadenectomy and splenectomy, types of surgery were the second group of prognostic factors.
  
  
  RESULTS
  Histological type and TNM stage of tumor as prognostic factors had a significant impact on local tumor recurrence. The type of surgery had no statistically significant value for tumor recurrence (p = 0.7520).
  
  
  CONCLUSIONS
  Statistical analysis of prognostic factors related to histopathologic characteristics of tumors and the type of surgery gave the results that had an impact on recurrence in gastric surgery patients. The most important prognostic factors were TNM stage of tumor and histological type of tumor that influenced the incidence of recurrence.
authors.affiliation: Department of Surgery, University Clinical Center Tuzla, Bosnia and Herzegovina.
authors.forename: Indira
authors.initials: I
authors.lastname: Mehmedagic
authors.affiliation: Department of Surgery, University Clinical Center Tuzla, Bosnia and Herzegovina.
authors.forename: Sefik
authors.initials: S
authors.lastname: Hasukic
authors.affiliation: Department of Surgery, University Clinical Center Tuzla, Bosnia and Herzegovina.
authors.forename: Mirha
authors.initials: M
authors.lastname: Agic
authors.affiliation: Centre for Heart BH Tuzla, Bosnia and Herzegovina.
authors.forename: Nedzad
authors.initials: N
authors.lastname: Kadric
authors.affiliation: Clinic for Internal Medicine, University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors.forename: Ismar
authors.initials: I
authors.lastname: Hasukic
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000368:Aged; D005260:Female; D005743:Gastrectomy / Q000379:methods; D006785:Hospitals, University; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
keywords: gastric adenocarcinoma; prognostic factors; recurrence; surgery