title: Orbital benign and malignant lymphoproliferative disorders: Differentiation using semi-quantitative and quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging.
abstract: OBJECTIVE
  To assess the value of dynamic contrast-enhanced MR imaging (DCE-MRI) in differentiating benign from malignant orbital lymphoproliferative disorders (OLPDs).
  
  
  METHODS
  Thirty-nine patients with orbital lymphoproliferative disorders (21 malignant and 18 benign) underwent DCE-MRI scan for pre-treatment evaluation from March 2013 to December 2015. Both semi-quantitative (TTP, AUC, Slopemax) and quantitative (Ktrans, kep, ve) parameters were calculated, and compared between two groups. Receiver operating characteristic (ROC) curve analyses were used to determine the diagnostic value of each significant parameter.
  
  
  RESULTS
  Malignant OLPDs showed significantly higher kep, lower ve, and lower AUC than benign OLPDs, while no significant differences were found on Ktrans, TTP and Slopemax. ROC analyses indicated that veexhibited the best diagnostic performance in predicting malignant OLPDs (cutoff value, 0.211; area under the curve, 0.896; sensitivity, 76.2%; specificity, 94.9%), followed by kep(cutoff value, 0.853; area under the curve, 0.839; sensitivity, 85.7%; specificity, 89.9%).
  
  
  CONCLUSIONS
  DCE-MRI and specially its derived quantitative parameters of kepand veare promising metrics for differentiating malignant from benign OLPDs.
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Xun-Ning
authors.initials: XN
authors.lastname: Hong
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Shi
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: wfydd_njmu@163.com.
authors.forename: Fei-Yun
authors.initials: FY
authors.lastname: Wu
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008232:Lymphoproliferative Disorders / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000000981:diagnostic imaging*; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media
keywords: Differential diagnosis; Dynamic contrast-enhanced; Lymphoproliferative disorders; Magnetic resonance imaging; Orbit