title: Emergence through delicate balance between the steric factor and molecular orientation: a highly bright and photostable DNA marker for real-time monitoring of cell growth dynamics.
abstract: Due to its remarkable structural and optical stability in biological milieu, a newly developed small molecule based DNA marker with high brightness (Φ = 0.51, brightness = 26 300 M-1cm-1) and almost zero toxicity has been explored. For the first time to our knowledge, this approach has provided real-time monitoring of growth and reproductive potency of living cells beyond nine days.
authors.affiliation: School of Basic Science, IIT Mandi, H.P.-175005, India. subrata@iitmandi.ac.in.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Gaur
authors.affiliation: Department of Biophysics PGIMER, Chandigarh, India. shalmoli2007@yahoo.co.in.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.affiliation: School of Basic Science, IIT Mandi, H.P.-175005, India. subrata@iitmandi.ac.in.
authors.forename: Reena
authors.initials: R
authors.lastname: Dalal
authors.affiliation: Department of Biophysics PGIMER, Chandigarh, India. shalmoli2007@yahoo.co.in.
authors.forename: Shalmoli
authors.initials: S
authors.lastname: Bhattacharyya
authors.affiliation: School of Basic Science, IIT Mandi, H.P.-175005, India. subrata@iitmandi.ac.in.
authors.forename: Subrata
authors.identifier: http://orcid.org/0000-0002-8030-4519
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D015415:Biomarkers / Q000737:chemistry; D049109:Cell Proliferation; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D055668:Photochemical Processes; D013997:Time Factors
chemical_list: D015415:Biomarkers; D005456:Fluorescent Dyes; D004247:DNA