title: Manganese and selenium concentrations in cerebrospinal fluid of seriously ill children.
abstract: BACKGROUND
  The homeostasis of essential trace elements such as selenium and manganese may be altered in patients with severe diseases of various etiologies (trauma brain injuries, tumors, leukemias, lymphomas, neurological diseases).
  
  
  METHODS
  Concentration of manganese and selenium were determined in cerebrospinal fluid by electrothermal atomic absorption spectrometry in 50 hospitalized children with various clinical ethiologies including oncological, neurological, and brain related diseases.
  
  
  RESULTS
  The concentrations of manganese in cerebrospinal fluid of children were 0.97±0.67 μg/L. The concentrations of selenium were 13.3±3.5 μg/L. The concentrations were similar as published in adults. The values did not correlated with the age, gender and severity of the disease.
  
  
  CONCLUSIONS
  We evaluated values of selenium and manganese in cerebrospinal fluid of seriously diseased children.
authors.affiliation: Department of Medical Chemistry and Clinical Biochemistry 2nd Faculty of Medicine, Faculty Hospital Motol, Charles University, Prague, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Franěk
authors.affiliation: Department of Medical Chemistry and Clinical Biochemistry 2nd Faculty of Medicine, Faculty Hospital Motol, Charles University, Prague, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Kotaška
authors.affiliation: Department of Medical Chemistry and Clinical Biochemistry 2nd Faculty of Medicine, Faculty Hospital Motol, Charles University, Prague, Czech Republic.
authors.forename: Richard
authors.initials: R
authors.lastname: Průša
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D057230:Limit of Detection; D016014:Linear Models; D008297:Male; D008345:Manganese / Q000134:cerebrospinal fluid*; D009369:Neoplasms / Q000134:cerebrospinal fluid; D012643:Selenium / Q000134:cerebrospinal fluid*; D013054:Spectrophotometry, Atomic
chemical_list: D008345:Manganese; D012643:Selenium
keywords: cerebrospinal fluid; children; electrothermal atomic absorption spectroscopy; manganese; selenium; values