title: Diagnostic role of detecting HPV in a FNAC of metastatic laterocervical lymph node in a case of occult HPV-related head and neck squamous cell carcinoma.
abstract: Human papillomavirus (HPV)-related head and neck squamous cell carcinomas (HNSCC) are radiosensitive tumors and have a better prognosis than the conventional keratinizing HNSCC. Despite extensive radiographic and clinical evaluation in approximately 3% to 5% of patients who present with cervical lymph node metastases, the primary tumor remains occult. The lack of a clinically identifiable primary tumor usually leads to more aggressive therapy, which can result in higher morbidity. Herein, we report a case of a patient with an occult HPV-related HNSCC, diagnosed detecting HPV in a fine needle aspiration cytology (FNAC) of metastatic laterocervical lymph nodes.
authors.affiliation: Department of Medical Biotechnologies, Anatomical Pathology Unit, University of Siena, Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ginori
authors.affiliation: Department of Medical Biotechnologies, Anatomical Pathology Unit, University of Siena, Siena, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Scaramuzzino
authors.affiliation: Department of Medical Biotechnologies, Anatomical Pathology Unit, University of Siena, Siena, Italy.
authors.forename: M A G
authors.initials: MA
authors.lastname: Munezero Butorano
authors.affiliation: Department of Medical Biotechnologies, Anatomical Pathology Unit, University of Siena, Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Barone
authors.affiliation: Cytopathology Unit, "Azienda Ospedaliera Universitaria Senese", Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Disanto
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000556:secondary / Q000628:therapy / Q000821:virology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000473:pathology / Q000628:therapy / Q000821:virology*; D061809:Human Papillomavirus DNA Tests; D052162:Human papillomavirus 16 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000473:pathology / Q000628:therapy / Q000821:virology*; D011237:Predictive Value of Tests; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004279:DNA, Viral
keywords: Basaloid squamous cell carcinoma; Fine-needle aspiration cytology; Human papillomavirus; Occult primary tumor