title: A novel case of lymphangiomatosis in HIV.
abstract: Diffuse lymphangiomatosis is a rare disorder characterized by abnormal proliferation of lymphatic channels. It can involve just one organ or multiple organs, such as liver, spleen, lungs, and bone. This disorder generally presents in children and young adults, but in rare cases, patients first present with symptoms in adulthood. Here, we describe a 48-year-old HIV-positive man who presented with shortness of breath. Computed tomography scan revealed a large right-sided pleural effusion and a heterogeneously enhancing liver. Thoracentesis demonstrated a chylous effusion and subsequent liver biopsy revealed a proliferation of dilated lymphatics to establish a diagnosis of lymphangiomatosis.
authors.affiliation: Department of Internal Medicine, Division of Infectious Disease, Harbor-ULCA Medical Center, 1000 West Carson Street, Torrance, CA 90509, United States. Electronic address: aspier@dhs.lacounty.gov.
authors.forename: Addie B
authors.initials: AB
authors.lastname: Spier
authors.affiliation: Department of Pathology, Harbor-ULCA Medical Center, 1000 West Carson Street, Torrance, CA 90509, United States.
authors.forename: Justin
authors.initials: J
authors.lastname: Kurtz
authors.affiliation: Department of Internal Medicine, Division of Infectious Disease, Harbor-ULCA Medical Center, 1000 West Carson Street, Torrance, CA 90509, United States.
authors.forename: David
authors.initials: D
authors.lastname: Sears
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D000068258:Bevacizumab / Q000627:therapeutic use; D049109:Cell Proliferation; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008202:Lymphangioma / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D042601:Lymphatic Vessels / Q000166:cytology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000378:metabolism; D011433:Propranolol / Q000627:therapeutic use; D020123:Sirolimus / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D018501:Antirheumatic Agents; D000068258:Bevacizumab; D011433:Propranolol; D020123:Sirolimus
keywords: Chylothorax; HIV; Lymphangiomatosis