title: Isolates of the emerging pathogen Candida auris present in the UK have several geographic origins.
abstract: Candida auris has recently emerged as a serious nosocomial health risk, with widespread outbreaks in numerous hospitals worldwide and the existence of geographic region-specific discrete clonal lineages. Here we have compared the rDNA sequences of 24 isolates of Candida auris from 14 different hospital centers in the United Kingdom with those of strains from different international origins present in the public sequence databases. Here we show that UK isolates of C. auris fall into three well-supported clades corresponding to lineages that have previously been reported from India, Malaysia and Kuwait, Japan and Korea, and South Africa, respectively.
authors.affiliation: UK National Mycology Reference Laboratory (MRL), Public Health England South-West, Bristol, United Kingdom.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Borman
authors.affiliation: UK National Mycology Reference Laboratory (MRL), Public Health England South-West, Bristol, United Kingdom.
authors.forename: Adrien
authors.initials: A
authors.lastname: Szekely
authors.affiliation: UK National Mycology Reference Laboratory (MRL), Public Health England South-West, Bristol, United Kingdom.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Johnson
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D003428:Cross Infection / Q000382:microbiology*; D004271:DNA, Fungal / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D010802:Phylogeny; D016415:Sequence Alignment; D006113:United Kingdom
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D021903:DNA, Ribosomal Spacer
keywords: Candida auris, emerging pathogen; United Kingdom; clonal strains; pathogenic yeasts; rDNA sequencing