title: Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer.
abstract: RNF4, a SUMO-targeted ubiquitin ligase, stabilizes a selected group of oncoproteins. It potentiates oncoprotein activity and serves as a positive feedback agonist of Wnt and Notch pathways. RNF4 is essential for cancer cell survival and its levels are elevated in human cancers, correlating with poor outcome in a subset of cancer patients.
authors.affiliation: Biozentrum University of Würzburg , Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Diefenbacher
authors.affiliation: Rappaport Research Institute and Faculty of Medicine, TICC, Technion - Israel Institute of Technology , Haifa, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Orian
keywords: Gene-regulation; RNF4; oncogene; phosphorylation; ubiquitin