title: Resistance ofShigellastrains to extended-spectrum cephalosporins in Isfahan province.
abstract: Background:The aim of this study was to determine the serotypes and antimicrobial susceptibility ofShigellaspp. in Isfahan, (Iran) from 2010 to 2015.Methods:This retrospective study was conducted onShigellaisolates in four tertiary care hospitals. The process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. The patients were categorized into three age groups of under 5, 5-15 and over 15 years.Results:Among 45 isolates,S. sonnei(63.6%) was the predominant species, followed byS. flexneri(34.1%), andS. dysenteriae(2.3%). Substantial resistance to ampicillin, trimethoprim- sulfamethoxazole, ceftriaxone, cefotaxime, and cefixime was observed. Over 94% of the isolates were sensitive to ciprofloxacin. Susceptibility of isolates was similar between all age groups.Conclusion:Significant resistance to third generation cephalosporins precludes the use of these agents for empirical treatment of shigellosis in our population. Ciprofloxacin is an appropriate option; however, susceptibility tests should be performed before prescription.
authors.affiliation: MD, Assistant Professor, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. n_mostafavy@med.mui.ac.ir.
authors.forename: Nasser
authors.initials: N
authors.lastname: Mostafavi
authors.affiliation: Medical student, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. mb.baran1920@yahoo.com.
authors.forename: Moein
authors.initials: M
authors.lastname: Bighamian
authors.affiliation: PhD of Microbiology, Nosocomial Infections Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. mobasherizadeh@gmail.com.
authors.forename: Sina
authors.initials: S
authors.lastname: Mobasherizade
authors.affiliation: MD, Professor, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. roya.kelishadi@gmail.com.
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
keywords: Ciprofloxacin; Iran; Shigellosis; Susceptibility; Third Generation Cephalosporin