title: Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals.
abstract: The ability to noninvasively assess arterial CD206+ macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease.
  
  
  
  We trialed a novel macrophage-specific arterial imaging technique.
  
  
  
  We demonstrated colocalization between technetium Tc 99m tilmanocept (99mTc-tilmanocept) and CD206+ macrophages ex vivo. In vivo application of 99mTc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99mTc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P = .009). Among all subjects, aortic high-level 99mTc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status.
  
  
  
  These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV.
  
  
  
  NCT02542371.
authors.affiliation: Program in Nutritional Metabolism and.
authors.forename: Markella V
authors.initials: MV
authors.lastname: Zanni
authors.affiliation: Program in Nutritional Metabolism and.
authors.forename: Mabel
authors.initials: M
authors.lastname: Toribio
authors.affiliation: Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston.
authors.forename: Moses Q
authors.initials: MQ
authors.lastname: Wilks
authors.affiliation: Cardiac MR PET CT Program, and.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lu
authors.affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts.
authors.forename: Tricia H
authors.initials: TH
authors.lastname: Burdo
authors.affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts.
authors.forename: Joshua
authors.initials: J
authors.lastname: Walker
authors.affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts.
authors.forename: Patrick
authors.initials: P
authors.lastname: Autissier
authors.affiliation: Cardiac MR PET CT Program, and.
authors.forename: Borek
authors.initials: B
authors.lastname: Foldyna
authors.affiliation: Program in Nutritional Metabolism and.
authors.forename: Lauren
authors.initials: L
authors.lastname: Stone
authors.affiliation: Program in Nutritional Metabolism and.
authors.forename: Amanda
authors.initials: A
authors.lastname: Martin
authors.affiliation: Navidea Biopharmaceuticals, Dublin, Ohio.
authors.forename: Fred
authors.initials: F
authors.lastname: Cope
authors.affiliation: Navidea Biopharmaceuticals, Dublin, Ohio.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Abbruzzese
authors.affiliation: Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brady
authors.affiliation: Cardiac MR PET CT Program, and.
authors.forename: Udo
authors.initials: U
authors.lastname: Hoffmann
authors.affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts.
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Williams
authors.affiliation: Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston.
authors.forename: Georges
authors.initials: G
authors.lastname: El-Fakhri
authors.affiliation: Program in Nutritional Metabolism and.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Grinspoon
mesh_terms: D001011:Aorta / Q000000981:diagnostic imaging; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000209:etiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003911:Dextrans; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008264:Macrophages / Q000166:cytology*; D008297:Male; D008351:Mannans; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000821:virology; D019275:Radiopharmaceuticals; D011956:Receptors, Cell Surface / Q000378:metabolism; D012044:Regression Analysis; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D016284:Technetium Tc 99m Pentetate / Q000031:analogs & derivatives; D014481:United States
chemical_list: D003911:Dextrans; D037181:Lectins, C-Type; D008351:Mannans; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D019275:Radiopharmaceuticals; D011956:Receptors, Cell Surface; C431884:technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran; D016284:Technetium Tc 99m Pentetate
keywords: HIV-associated cardiovascular disease; arterial inflammation; atherosclerosis.