title: MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39.
abstract: Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreatic cancer tissues and cell lines and elevated expression of miR-451 contributes to promoted cell viability (in vitro and in vivo). Moreover, overexpression of miR-451 is closely linked to poor prognosis and lymphatic metastasis. Inhibition of miR-451 dramatically suppresses cell viability and invasion, promotes cell apoptosis, and induces cell cycle arrest. Furthermore, miR-451 directly targets CAB39 and negatively regulates its expression and inhibition of CAB39 contributes to the promoted cell viability and invasion. Our findings improve our understanding of the function of miR-451 in the identification and therapy of pancreatic cancer.
authors.affiliation: General Surgery Department, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Rende
authors.identifier: 0000-0001-8696-7869
authors.initials: R
authors.lastname: Guo
authors.affiliation: General Surgery Department, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Gu
authors.affiliation: General Surgery Department, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: General Surgery Department, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Yi
authors.identifier: 0000-0003-3106-5838
authors.initials: Y
authors.lastname: Wang
authors.affiliation: General Surgery Department, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Chuan
authors.identifier: 0000-0002-4823-5613
authors.initials: C
authors.lastname: Gu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002135:Calcium-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D059447:Cell Cycle Checkpoints / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: C540569:CAB39 protein, human; D002135:Calcium-Binding Proteins; C531201:MIRN451 microRNA, human; D035683:MicroRNAs