title: Increased Fas ligand expression of peripheral B-1 cells correlated with CD4+T-cell apoptosis in filarial-infected patients.
abstract: Cellular hyporesponsiveness observed during helminth infections is attributed to factors such as antigen-presenting cells (APC) dysfunction, increased interleukin-10(IL-10), regulatory T cells and induction of CD4+T (Th)-cell apoptosis. Increased Fas ligand (FasL) expression on the surface of B-1 cells and induction of apoptosis of Th cells by FasL-expressing B-1 cells due to helminth infection were demonstrated in murine model of helminth infection where as profile of FasL expression, Th-cell apoptosis and correlation between these two populations of cells in clinical filariasis remain unknown. In this study, we have scored the profile of apoptotic Th-cell population and FasL-expressing B-1 cells in different clinical categories of filariasis. The peripheral apoptotic T-helper cells were significantly increased in filarial patients compared to endemic controls. Expression of FasL on the surface of peripheral B-1 cells increased in filarial patients and positively correlated with peripheral apoptotic T-helper cells indicating FasL-expressing B-1 cells may be one of the important mediators of Th-cell apoptosis and immune anergy during filarial pathology.
authors.affiliation: Regional Medical Research Centre (ICMR), Bhubaneswar, Odisha, India.
authors.forename: R
authors.initials: R
authors.lastname: Mishra
authors.affiliation: Institutes of Life Sciences (DBT), Bhubaneswar, Odisha, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Panda
authors.affiliation: Regional Medical Research Centre (ICMR), Bhubaneswar, Odisha, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Sahoo
authors.affiliation: Regional Medical Research Centre (ICMR), Bhubaneswar, Odisha, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Bal
authors.affiliation: Regional Medical Research Centre (ICMR), Bhubaneswar, Odisha, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Satapathy
mesh_terms: D017209:Apoptosis; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D001402:B-Lymphocytes / Q000378:metabolism; D017635:Clonal Anergy; D053222:Fas Ligand Protein / Q000235:genetics; D005368:Filariasis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000473:pathology; D019014:fas Receptor / Q000378:metabolism
chemical_list: C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C508609:IL10 protein, human; D008562:Membrane Glycoproteins; D019014:fas Receptor; D016753:Interleukin-10
keywords: B-1 cells; CD4+ T cells; FasL; apoptosis; lymphatic filariasis