title: eIF2α links mitochondrial dysfunction to dendritic degeneration.
abstract: Although mitochondrial dysfunction has been associated with dendritic pathology in many neuronal types, how mitochondrial impairment causes the vulnerability of neuronal subtypes remains unknown. In this issue, Tsuyama et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201604065) identify eIF2α phosphorylation as a critical regulator of mitochondrial dysfunction-mediated selective dendritic loss inDrosophilaneurons.
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 xxq38@case.edu.
authors.forename: Xin
authors.identifier: 0000-0002-9578-3890
authors.initials: X
authors.lastname: Qi
mesh_terms: D003712:Dendrites / Q000378:metabolism* / Q000502:physiology*; D005057:Eukaryotic Cells / Q000378:metabolism / Q000502:physiology; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000502:physiology
chemical_list: D015852:Eukaryotic Initiation Factor-2