title: Development of Oromucosal Dosage Forms by Combining Electrospinning and Inkjet Printing.
abstract: Printing technology has been shown to enable flexible fabrication of solid dosage forms for personalized drug therapy. Several methods can be applied for tailoring the properties of the printed pharmaceuticals. In this study, the use of electrospun fibrous substrates in the fabrication of inkjet-printed dosage forms was investigated. A single-drug formulation with lidocaine hydrochloride (LH) and a combination drug system containing LH and piroxicam (PRX) for oromucosal administration were prepared. The LH was deposited on the electrospun and cross-linked gelatin substrates by inkjet printing, whereas PRX was incorporated within the substrate fibers during electrospinning. The solid state analysis of the electrospun substrates showed that PRX was in an amorphous state within the fibers. Furthermore, the results indicated the entrapment and solidification of the dissolved LH within the fibrous gelatin matrix. The printed drug amount (2-3 mg) was in good correlation with the theoretical dose calculated based on the printing parameters. However, a noticeable degradation of the printed LH was detected after a few months. An immediate release (over 85% drug release after 8 min) of both drugs from the printed dosage forms was observed. In conclusion, the prepared electrospun gelatin scaffolds were shown to be suitable substrates for inkjet printing of oromucosal formulations. The combination of electrospinning and inkjet printing allowed the preparation of a dual drug system.
authors.affiliation: Institute of Pharmacy, Faculty of Medicine, University of Tartu , Nooruse 1, EE-50411 Tartu, Estonia.|Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University , Tykistökatu 6A, FI-20520 Turku, Finland.
authors.forename: Mirja
authors.identifier: 0000-0003-3108-6049
authors.initials: M
authors.lastname: Palo
authors.affiliation: Institute of Pharmacy, Faculty of Medicine, University of Tartu , Nooruse 1, EE-50411 Tartu, Estonia.
authors.forename: Karin
authors.initials: K
authors.lastname: Kogermann
authors.affiliation: Institute of Pharmacy, Faculty of Medicine, University of Tartu , Nooruse 1, EE-50411 Tartu, Estonia.
authors.forename: Ivo
authors.initials: I
authors.lastname: Laidmäe
authors.affiliation: Institute of Pharmacy, Faculty of Medicine, University of Tartu , Nooruse 1, EE-50411 Tartu, Estonia.
authors.forename: Andres
authors.initials: A
authors.lastname: Meos
authors.affiliation: Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University , Tykistökatu 6A, FI-20520 Turku, Finland.
authors.forename: Maren
authors.initials: M
authors.lastname: Preis
authors.affiliation: Institute of Pharmacy, Faculty of Medicine, University of Tartu , Nooruse 1, EE-50411 Tartu, Estonia.
authors.forename: Jyrki
authors.identifier: 0000-0002-5996-5144
authors.initials: J
authors.lastname: Heinämäki
authors.affiliation: Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University , Tykistökatu 6A, FI-20520 Turku, Finland.
authors.forename: Niklas
authors.initials: N
authors.lastname: Sandler
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005780:Gelatin / Q000737:chemistry; D008012:Lidocaine / Q000737:chemistry; D009061:Mouth Mucosa / Q000378:metabolism*; D010894:Piroxicam / Q000737:chemistry*; D011327:Printing / Q000379:methods; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D004304:Dosage Forms; D010894:Piroxicam; D005780:Gelatin; D008012:Lidocaine
keywords: cross-linked gelatin; electrospinning; inkjet printing; lidocaine hydrochloride; oromucosal drug delivery; piroxicam