title: First isolation of the pan-azole-resistant Aspergillus fumigatus cyp51A TR46/Y121F/T289A mutant in a UK patient.
authors.affiliation: Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK; National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Moore
authors.affiliation: Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
authors.forename: Lily
authors.initials: L
authors.lastname: Novak-Frazer
authors.affiliation: National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
authors.forename: Eavan
authors.initials: E
authors.lastname: Muldoon
authors.affiliation: The Adult Burns Centre, University Hospital of South Manchester, Manchester, UK.
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Dunn
authors.affiliation: Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK.
authors.forename: Rikesh
authors.initials: R
authors.lastname: Masania
authors.affiliation: Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK; National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
authors.forename: Malcolm D
authors.initials: MD
authors.lastname: Richardson
authors.affiliation: Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK; National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Electronic address: riina.richardson@manchester.ac.uk.
authors.forename: Riina
authors.initials: R
authors.lastname: Rautemaa-Richardson
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D001393:Azoles / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D025141:Drug Resistance, Fungal / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D020125:Mutation, Missense; D006113:United Kingdom
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D005656:Fungal Proteins; D003577:Cytochrome P-450 Enzyme System; C465526:cytochrome P-450 CYP51A, Aspergillus