title: Onset of bladder and motor symptoms in multiple system atrophy: differences according to phenotype.
abstract: To compare the order of presentation of bladder and motor symptoms between multiple system atrophy phenotypes.
  
  
  
  Medical records were retrospectively reviewed in 144 patients.
  
  
  
  Bladder symptoms occurred either before or within 12 months after onset of motor symptoms in significantly more patients with the cerebellar phenotype than the parkinsonian phenotype (80 vs. 53%, p = 0.003); similar results were observed for urinary incontinence (79 vs. 45%, p = 0.001).
  
  
  
  Urinary dysfunction is more likely to appear either before or shortly after motor symptoms in the cerebellar phenotype than in the parkinsonian phenotype.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Xinglong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Yalan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Quanzhen
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Sijia
authors.initials: S
authors.lastname: Tian
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China. neuroxym999@163.com.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D019578:Multiple System Atrophy / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D010641:Phenotype; D012189:Retrospective Studies; D001745:Urinary Bladder Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*
keywords: Autonomic dysfunction; Multiple system atrophy; Orthostatic hypotension; Urinary incontinence