title: A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.
abstract: Cell adhesion is crucial for cells to not only physically interact with each other but also sense their microenvironment and respond accordingly. In fact, adherent cells can generate physical forces that are transmitted to the surrounding matrix, regulating the formation of cell-matrix adhesions. The main purpose of this work is to develop a computational model to simulate the dynamics of cell-matrix adhesions through a cohesive formulation within the framework of the finite element method and based on the principles of continuum damage mechanics. This model enables the simulation of the mechanical adhesion between cell and extracellular matrix (ECM) as regulated by local multidirectional forces and thus predicts the onset and growth of the adhesion. In addition, this numerical approach allows the simulation of the cell as a whole, as it models the complete mechanical interaction between cell and ECM. As a result, we can investigate and quantify how different mechanical conditions in the cell (e.g., contractile forces, actin cytoskeletal properties) or in the ECM (e.g., stiffness, external forces) can regulate the dynamics of cell-matrix adhesions.
authors.affiliation: Department of Mechanical Engineering, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Cóndor
authors.affiliation: Department of Mechanical Engineering, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain. jmgaraz@unizar.es.
authors.forename: J M
authors.identifier: 0000-0002-9864-7683
authors.initials: JM
authors.lastname: García-Aznar
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D021982:Cell-Matrix Junctions / Q000502:physiology; D003198:Computer Simulation; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D008954:Models, Biological
keywords: Cohesive interfaces; Cytoskeletal contractility; Finite element simulation; Focal adhesions; Mechanosensitive linkage