title: The Prevalence of Migraine in Iran: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Migraine is a major dilemma and problem which affects public health and results to reduced quality of life. This study aimed to determine the prevalence of migraine in Iran.
  
  
  METHODS
  A systematic search was conducted using Pub Med, Web of Science, Embase, Scopus, Ovid, Google Scholar, as well as Iranian databases including: MagIran, IranMedex and Scientific Information Databank, from 2000 to November, 2015. The Der-Simonian/Laird's random-effects model, with a 95% confidence interval was employed to estimate the overall pooled prevalence. Heterogeneity was investigated using subgroup analysis based on sample size and time of study.
  
  
  RESULTS
  Thirty studies comprising 33,873 participants met the inclusion criteria for the analysis. The overall prevalence of migraine in Iran was 14% (95% CI, 12% to 17%), respectively. The overall prevalence was (8%; 95% CI 6% to 11%) according to the international classification of headache disorders (ICHD-1), (17%; 95% CI 13% to 21%) according to ICHD-2, and (18%; 95% CI 7% to 30%) according to the other questionnaire for migraine screener (ID Migraine), respectively. Meta-regression demonstrated that the prevalence of migraine increased by year of publication and decreased by sample size.
  
  
  CONCLUSIONS
  The prevalence of migraine in Iran, which was estimated as 14%, was similar or even higher than that reported world-wide. Migraine can have impact on the economic productivity of any country; therefore it is necessary to educate people on the early detection and the discovery of an effective treatment of migraine. More thorough review of further studies in this field is recommended.
authors.affiliation: School of Medicine, Babol University of Medical Sciences, Babol, IR Iran.
authors.forename: Zeynab
authors.initials: Z
authors.lastname: Farhadi
authors.affiliation: Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Saeideh
authors.initials: S
authors.lastname: Alidoost
authors.affiliation: Department of Public Health, Faculty of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, IR Iran.
authors.forename: Meysam
authors.initials: M
authors.lastname: Behzadifar
authors.affiliation: Hamadan University of Medical Sciences, Hamadan, IR Iran.
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Mohammadibakhsh
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, IR Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Khodadadi
authors.affiliation: Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Razieh
authors.initials: R
authors.lastname: Sepehrian
authors.affiliation: Iranian Social Security Organization, Zanjan Province Health Administration, Zanjan, IR Iran.
authors.forename: Rahim
authors.initials: R
authors.lastname: Sohrabi
authors.affiliation: Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Masood
authors.initials: M
authors.lastname: Taheri Mirghaed
authors.affiliation: Social Determinants in Health Promotion Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Salemi
authors.affiliation: Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Ravaghi
authors.affiliation: Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, IR Iran; Department of Public Health, Faculty of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, IR Iran; Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Behzadifar
keywords: Iran; Meta-Analysis; Migraine; Prevalence