title: Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection.
abstract: Curative therapies are most successful when cancer is diagnosed and treated at an early stage. We advocate that technological advances in next-generation sequencing of circulating, tumor-derived nucleic acids hold promise for addressing the challenge of developing safe and effective cancer screening tests.
authors.affiliation: GRAIL, Menlo Park, CA 94402, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Aravanis
authors.affiliation: GRAIL, Menlo Park, CA 94402, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Lee
authors.affiliation: GRAIL, Menlo Park, CA 94402, USA. Electronic address: klausner.rick@gmail.com.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Klausner
mesh_terms: D004247:DNA / Q000097:blood*; D055088:Early Detection of Cancer; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D004247:DNA