title: Theta-burst transcranial magnetic stimulation to the prefrontal or parietal cortex does not impair metacognitive visual awareness.
abstract: Neuroimaging studies commonly associate dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex with conscious perception. However, such studies only investigate correlation, rather than causation. In addition, many studies conflate objective performance with subjective awareness. In an influential recent paper, Rounis and colleagues addressed these issues by showing that continuous theta burst transcranial magnetic stimulation (cTBS) applied to the DLPFC impaired metacognitive (subjective) awareness for a perceptual task, while objective performance was kept constant. We attempted to replicate this finding, with minor modifications, including an active cTBS control site. Using a between-subjects design for both DLPFC and posterior parietal cortices, we found no evidence of a cTBS-induced metacognitive impairment. In a second experiment, we devised a highly rigorous within-subjects cTBS design for DLPFC, but again failed to find any evidence of metacognitive impairment. One crucial difference between our results and the Rounis study is our strict exclusion of data deemed unsuitable for a signal detection theory analysis. Indeed, when we included this unstable data, a significant, though invalid, metacognitive impairment was found. These results cast doubt on previous findings relating metacognitive awareness to DLPFC, and inform the current debate concerning whether or not prefrontal regions are preferentially implicated in conscious perception.
authors.affiliation: Sackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom.|Department of Informatics, University of Sussex, Brighton, United Kingdom.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bor
authors.affiliation: Sackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom.|Department of Informatics, University of Sussex, Brighton, United Kingdom.
authors.forename: David J
authors.initials: DJ
authors.lastname: Schwartzman
authors.affiliation: Sackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom.|Department of Informatics, University of Sussex, Brighton, United Kingdom.
authors.forename: Adam B
authors.initials: AB
authors.lastname: Barrett
authors.affiliation: Sackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom.|Department of Informatics, University of Sussex, Brighton, United Kingdom.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Seth
mesh_terms: D000293:Adolescent; D000328:Adult; D001364:Awareness / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D000067489:Metacognition / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D013826:Theta Rhythm; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult