title: Risk factors for brain metastases after prophylactic cranial irradiation in small cell lung cancer.
abstract: Despite administration of prophylactic cranial irradiation (PCI), some small cell lung cancer (SCLC) patients still suffer from brain metastases (BM) with unknown risk factors. We conducted this study to identify patients with higher BM risk after PCI and improve their outcome. The characteristics and survival of all the SCLC patients underwent PCI in our institute from 2003 to 2014 were analyzed. Kaplan-Meier method was applied to estimate BM free survival (BMFS) and overall survival (OS). Cox regression analyses were performed to explore risk factors for BM. A total of 175 patients with the median age of 55 years (range, 29-76) were eligible, among whom 36 (20.6%) developed BM with median follow-up of 42 months. Both univariate and multivariate analyses showed HART and TNM classification (p < 0.05) were associated with BM. Two-stage system was not related with BMFS or OS (p > 0.05). Stage IIIB-IV and HART were independent risk factors for BM after PCI in SCLC. TNM classification was more valuable on prognosis than two-stage system. Further large-scale studies are needed to confirm our findings.
authors.affiliation: School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong 250022, China.|Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Shuanghu
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Xindong
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Wanlong
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Bingjie
authors.initials: B
authors.lastname: Fan
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China.|Shandong Academy of Medical Sciences, Jinan 250022, Shandong, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000517:prevention & control / Q000532:radiotherapy / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis