title: More to cohesin than meets the eye: complex diversity for fine-tuning of function.
abstract: Recent years have witnessed a dramatic expansion in our understanding of gene control. It is now widely appreciated that the spatial organization of the genome and the manner in which genes and regulatory elements are embedded therein has a critical role in facilitating the regulation of gene expression. The loop structures that underlie chromosome organization are anchored by cohesin complexes. Several components of the cohesin complex have multiple paralogs, leading to different levels of cohesin complex variants in cells. Here we review the current literature around cohesin variants and their known functions. We further discuss how variation in cohesin complex composition can result in functional differences that can impact genome organization and determine cell fate.
authors.affiliation: Research Department of Cancer Biology, Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom.
authors.forename: Dubravka
authors.initials: D
authors.lastname: Pezic
authors.affiliation: Research Department of Cancer Biology, Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom.
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Weeks
authors.affiliation: Research Department of Cancer Biology, Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom. Electronic address: s.hadjur@ucl.ac.uk.
authors.forename: Suzana
authors.initials: S
authors.lastname: Hadjur
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D000097722:Cohesins