title: Calcium Channels in Vascular Smooth Muscle.
abstract: Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i. In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.
authors.affiliation: University of California, Davis, CA, United States.
authors.forename: D
authors.initials: D
authors.lastname: Ghosh
authors.affiliation: University of California, Davis, CA, United States.
authors.forename: A U
authors.initials: AU
authors.lastname: Syed
authors.affiliation: University of California, Davis, CA, United States.
authors.forename: M P
authors.initials: MP
authors.lastname: Prada
authors.affiliation: Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States.
authors.forename: M A
authors.initials: MA
authors.lastname: Nystoriak
authors.affiliation: University of California, Davis, CA, United States.
authors.forename: L F
authors.initials: LF
authors.lastname: Santana
authors.affiliation: University of California, Davis, CA, United States.
authors.forename: M
authors.initials: M
authors.lastname: Nieves-Cintrón
authors.affiliation: University of California, Davis, CA, United States. Electronic address: mfnavedo@ucdavis.edu.
authors.forename: M F
authors.initials: MF
authors.lastname: Navedo
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Arteries; Ca(2+) signaling; Contraction; Ion channels; Myogenic tone; Sarcoplasmic reticulum