title: Predictive Factors for Complete Response and Recurrence after Transarterial Chemoembolization in Hepatocellular Carcinoma.
abstract: OBJECTIVE
  To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE).
  
  
  METHODS
  Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS).
  
  
  RESULTS
  Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43.2%). In multivariate analyses, tumor size (≤5 cm) and single nodularity were predictive factors for CR, with hazard ratios (HRs) of 0.35 (p=0.002) and 0.41 (p<0.001), respectively. Elevated serum α-fetoprotein (AFP) (>20 ng/mL) level and multinodularity exhibited significant relationships with recurrence after CR, with HRs of 2.220 (p=0.026) and 3.887 (p<0.001), respectively. Tumor size (>5 cm), multinodularity, elevated serum AFP (>20 ng/mL) level, Child-Turcotte-Pugh score (B and C), and portal vein thrombosis were significant factors for OS.
  
  
  CONCLUSIONS
  In patients treated with TACE as a first therapy, tumor size (≤5 cm) and single nodularity were predictive factors for CR, and multinodularity and elevated serum AFP (>20 ng/mL) levels were predictive factors for recurrence after CR. These factors were also significant for OS.
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Shin Ok
authors.initials: SO
authors.lastname: Jeong
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Eui Bae
authors.initials: EB
authors.lastname: Kim
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Soung Won
authors.initials: SW
authors.lastname: Jeong
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Jang
authors.affiliation: Department of Internal Medicine, Soonchunhyang University Hospital, Cheonan, Korea.
authors.forename: Sae Hwan
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Korea.
authors.forename: Sang Gyune
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Cha
authors.affiliation: Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Korea.
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Young Deok
authors.initials: YD
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Soonchunhyang University Hospital, Cheonan, Korea.
authors.forename: Hong Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Boo Sung
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Radiology, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Yong Jae
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Radiology, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Dong Erk
authors.initials: DE
authors.lastname: Goo
authors.affiliation: Department of Biostatistics, Soonchunhyang University Hospital, Seoul, Korea.
authors.forename: Su Yeon
authors.initials: SY
authors.lastname: Park
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000150:complications / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000209:etiology; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins
keywords: Carcinoma; Chemoembolization; Complete response; Recurrence; hepatocellular; therapeutic