title: Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks.
abstract: Replication-dependent double-strand breaks (DSBs) are the main source of genomic instability as their inaccurate repair stimulates chromosomal rearrangements. In a recent work, we uncover a novel regulatory circuit that involves the Werner's syndrome helicase and CDK1, and that is essential for repair pathway choice at replication-dependent DSBs.
authors.affiliation: Section of Experimental and Computational Carcinogenesis, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Palermo
authors.affiliation: Proteomics Laboratory, Department of Ecology and Biology, Università della Tuscia , Viterbo, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Rinalducci
authors.affiliation: Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: Section of Experimental and Computational Carcinogenesis, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Grillini
authors.affiliation: Section of Molecular Epidemiology, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Annapaola
authors.initials: A
authors.lastname: Franchitto
authors.affiliation: Section of Experimental and Computational Carcinogenesis, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Pichierri
keywords: DNA repair; WRN protein; end-resection