title: Multimodal Analgesia for Acute Postoperative and Trauma-Related Pain.
abstract: : Multimodal analgesia, which combines analgesic drugs from different classes and employs analgesic techniques that target different mechanisms of pain, is recommended in the treatment of acute postoperative and trauma-related pain because its synergistic effect maximizes pain relief at lower analgesic doses, thereby reducing the risk of adverse drug effects. Using a case-based approach, this article reviews various multimodal analgesic therapies used in the treatment of acute pain; discusses their benefits; and summarizes findings from related research, recommendations from evidence-based practice guidelines, and expert consensus reports.
authors.affiliation: Rosemary C. Polomano is a professor of pain practice at the University of Pennsylvania School of Nursing, Philadelphia. Mechele Fillman is an NP for the acute pain service in the Division of Pain Medicine at Stanford Hospital and Clinics, Stanford, CA. Nicholas A. Giordano is a PhD student and Hillman Scholar in Nursing Innovation at the University of Pennsylvania School of Nursing. April Hazard Vallerand is associate dean for research and director of the PhD program at Wayne State University College of Nursing, Detroit. Kelly L. Wiltse Nicely is an assistant professor of nurse anesthesia in the Department of Biobehavioral Health Sciences, University of Pennsylvania School of Nursing. Carla R. Jungquist is an assistant professor in the University at Buffalo School of Nursing, Buffalo, NY. Contact author: Rosemary C. Polomano, polomanr@nursing.upenn.edu. Rosemary C. Polomano has served on the advisory boards of Salix Pharmaceuticals, Daiichi Sankyo, and Mallinckrodt Pharmaceuticals; April Hazard Vallerand is on the speaker's bureaus of AstraZeneca and Purdue Pharma and is a consultant for Shionogi, Inc.; and Carla R. Jungquist has served on the advisory board of Mallinckrodt Pharmaceuticals. The authors have disclosed no potential conflicts of interest, financial or otherwise.
authors.forename: Rosemary C
authors.initials: RC
authors.lastname: Polomano
authors.forename: Mechele
authors.initials: M
authors.lastname: Fillman
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Giordano
authors.forename: April Hazard
authors.initials: AH
authors.lastname: Vallerand
authors.forename: Kelly L Wiltse
authors.initials: KL
authors.lastname: Nicely
authors.forename: Carla R
authors.initials: CR
authors.lastname: Jungquist
mesh_terms: D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D059408:Pain Management / Q000379:methods; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid