title: Hematite-Based Photoelectrode Materials for Photoelectrocatalytic Inhibition of Alzheimer's β-Amyloid Self-Assembly.
abstract: A visible light-active, hematite-based photoelectrode platform for suppressing β-amyloid (Aβ) self-assembly in vitro is reported. Upon illumination of a light-emitting diode with an anodic bias, the hematite photoanode generates reactive radical species, such as superoxide ions and hydroxyl radicals, via photoelectrocatalytic process. According to our analyses, the hematite photoanode exhibited a strong inhibitory effect on Aβ aggregation under visible light illumination and anodic bias. We found that hole-derived radicals played a significant role of oxidizing Aβ peptides, which effectively blocked further aggregation. The efficacy of photoelectrocatalytic inhibition on Aβ aggregation was enhanced by introducing cobalt phosphate (Co-Pi) as a co-catalyst on the hematite photoanode, which facilitated the separation of electron-hole pairs. We verified that both bare and Co-Pi@hematite photoanodes are biocompatible and effective in reducing Aβ aggregation-induced cytotoxicity.
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
authors.forename: Kayoung
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
authors.forename: Byung Il
authors.initials: BI
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
authors.forename: You Jung
authors.initials: YJ
authors.lastname: Chung
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
authors.forename: Woo Seok
authors.initials: WS
authors.lastname: Choi
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D004566:Electrodes; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D066263:Protein Aggregation, Pathological
chemical_list: D016229:Amyloid beta-Peptides; D005290:Ferric Compounds; C000499:ferric oxide
keywords: Alzheimer's disease; hematite; photoanode materials; self-assembly; β-amyloid peptides