title: Short-term effects of troxerutin (vitamin P4) on muscle fatigue and gene expression of Bcl-2 and Bax in the hepatic tissue of rats.
abstract: In the current study, the effects of troxerutin (TRX) on muscle fatigue and gene expression of Bcl-2 and Bax in the hepatic tissue of rats was investigated. Forty male Wistar rats were randomly divided into 4 groups and designated as control and TRX treatment at 75 (TRX75), 150 (TRX150), and 300 mg/kg per day (TRX300). The treated groups and control group received TRX and water orally for 7 days. After an exhaustive swimming test on the 7th day, all animals were euthanized immediately and several biochemical parameters related to fatigue and gene expression of Bcl-2 and Bax in the hepatic tissue were measured. Our results showed that the exhaustion swimming time in the TRX300 groups significantly increased 1.2-fold compared with the control group (P < 0.001). TRX300 significantly reduced ALT (P < 0.05) activity and increased liver SOD activity compared with the control group (P < 0.01). Additionally, TRX significantly reduced the liver mRNA expressions of Bax (P < 0.001) and increased the Bcl-2/Bax ratio (P < 0.001) compared with the control group. Based on our data, TRX possesses anti-apoptotic and hepatoprotective action following exhaustive swimming exercise.
authors.affiliation: a Physiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zamanian
authors.affiliation: a Physiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Shamsizadeh
authors.affiliation: b Department of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Esmaeili Nadimi
authors.affiliation: c Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Hajizadeh
authors.affiliation: d College of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Allahtavakoli
authors.affiliation: a Physiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Rahmani
authors.affiliation: a Physiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Ayat
authors.initials: A
authors.lastname: Kaeidi
authors.affiliation: a Physiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Safari Khalegh
authors.affiliation: a Physiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Allahtavakoli
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013550:Swimming; D051028:bcl-2-Associated X Protein / Q000235:genetics* / Q000378:metabolism
chemical_list: D006896:Hydroxyethylrutoside; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; C005865:troxerutin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: apoptose; apoptosis; exercice physique menant à l’épuisement; exhaustive exercise; fatigue musculaire; muscle fatigue; oxidative stress; stress oxydatif; troxerutin; troxérutine