title: Molecular finds of pressure ulcer: A bioinformatics approach in pressure ulcer.
abstract: BACKGROUND
  Understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases.
  
  
  OBJECTIVE
  This study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics.
  
  
  METHODS
  We performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation. Interactions networks between protein-coding genes were built and compared to skin.
  
  
  RESULTS
  TNFA, MMP9, and IL10 genes have higher disease-related connectivity than a connectivity general global. MAGOH, UBC, and PTCH1 as were leader genes related to skin. Ontological analysis demonstrated different mechanisms associated, such as response to oxidase stress.
  
  
  CONCLUSIONS
  TNFA, MMP9, and IL10 are possible therapeutic targets for pressure ulcer. Additional investigation of cell post-transcriptional machinery should be investigated in PU.
authors.affiliation: Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Eloa Mangabeira
authors.initials: EM
authors.lastname: Santos
authors.affiliation: Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Lucyana Conceição
authors.initials: LC
authors.lastname: Farias
authors.affiliation: Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil.
authors.forename: Sérgio Henrique Sousa
authors.initials: SHS
authors.lastname: Santos
authors.affiliation: Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Alfredo Maurício Batista
authors.initials: AMB
authors.lastname: de Paula
authors.affiliation: Department of Nursery, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Carla Silvana de
authors.initials: CS
authors.lastname: Oliveira E Silva
authors.affiliation: Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil. Electronic address: andreluizguimaraes@gmail.com.
authors.forename: André Luiz Sena
authors.initials: ALS
authors.lastname: Guimarães
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D015870:Gene Expression; D006801:Humans; D003668:Pressure Ulcer / Q000235:genetics*
keywords: Diabet ulcer; Inflammation; Leader gene; Network