title: Metabolic pathways regulated by p63.
abstract: The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for ΔNp63 and TAp63, respectively. Recently, p53 and TAp73, in line with other tumour suppressor genes, have emerged as important regulators of energy metabolism and metabolic reprogramming in cancer. To date, p63 contributions in controlling energy metabolism have been partially investigated; given the extensive interaction of the p53 family members, these studies have potential implications in tumour cells for metabolic reprogramming. Here, we review the role of p63 isoforms, TAp63 and ΔNp63, in controlling cell metabolism, focusing on their specific metabolic target genes and their physiological/functional context of action.
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy; IDI-IRCCS "Istituto Dermopatico dell'Immacolata", Biochemistry Laboratory, Rome, Italy. Electronic address: candi@uniroma2.it.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Candi
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Artem
authors.initials: A
authors.lastname: Smirnov
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Panatta
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Lena
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Novelli
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK.
authors.forename: Mara
authors.initials: M
authors.lastname: Mancini
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK.
authors.forename: Giuditta
authors.initials: G
authors.lastname: Viticchiè
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Piro
authors.affiliation: Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Daniele
authors.affiliation: IDI-IRCCS "Istituto Dermopatico dell'Immacolata", Biochemistry Laboratory, Rome, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Annicchiarico-Petruzzelli
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy; Medical Research Council, Toxicology Unit, Leicester LE1 9HN, UK. Electronic address: melino@uniroma2.it.
authors.forename: Gerry
authors.initials: G
authors.lastname: Melino
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D053858:Metabolic Networks and Pathways; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D020033:Protein Isoforms; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D005947:Glucose
keywords: Glycolysis; Metabolism; p53 family; p63