title: Sorting out adipocyte precursors and their role in physiology and disease.
abstract: The ability to maintain and expand the pool of adipocytes in adults is integral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For decades, our knowledge of adipocyte precursors has relied on cellular models. The identity of native adipocyte precursors has remained unclear. Recent studies have identified distinct adipocyte precursor populations that are physiologically regulated and contribute to the development, maintenance, and expansion of adipocyte pools in mice. With new tools available, the properties of adipocyte precursors can now be defined, and the regulation and function of adipose plasticity in development and physiology can be explored.
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Chelsea
authors.initials: C
authors.lastname: Hepler
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Vishvanath
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Rana K
authors.initials: RK
authors.lastname: Gupta
mesh_terms: D052437:Adipocytes, Brown / Q000166:cytology*; D052438:Adipocytes, White / Q000166:cytology*; D050156:Adipogenesis; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D012106:Research / Q000639:trends
keywords: adipocyte precursor; adipogenesis; beige adipocytes; brown adipocytes; white adipocytes