title: Applications of the Wittig-Still Rearrangement in Organic Synthesis.
abstract: This Review traces the discovery of the Wittig-Still rearrangement and its applications in organic synthesis. Its relationship to Wittig rearrangements is discussed along with detailed analysis of E/Z- and diastereoselectivity. Modifications of the products arising from the Wittig-Still rearrangement are reviewed in the context of increased complexity in intermediates potentially useful in target-oriented synthesis. Early applications of the Wittig-Still rearrangement to modifications of steroids are reviewed as are applications to various terpene and alkaloid natural product targets and miscellaneous compounds. To the best of our knowledge, the literature is covered through December 2016.
authors.affiliation: Department of Chemistry and Centre for Biotechnology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada.
authors.forename: Lukas
authors.initials: L
authors.lastname: Rycek
authors.affiliation: Department of Chemistry and Centre for Biotechnology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada.
authors.forename: Tomas
authors.initials: T
authors.lastname: Hudlicky
keywords: Wittig-Still  rearrangement; natural products synthesis; sigmatropic rearrangement; stereoselective synthesis; synthetic methods