title: Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond.
abstract: Autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. Guillain-Barré syndrome (GBS), an autoimmune peripheral neuropathy, has been recently associated with Zika virus (ZIKV) infection. Based on a series of cases, this review article provides a comparative analysis of GBS associated with ZIKV infection, contrasted with the general characteristics of GBS in light of the autoimmune tautology, including gender differences in prevalence, subphenotypes, polyautoimmunity, familial autoimmunity, age at onset, pathophysiology, ecology, genetics, ancestry, and treatment.
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Pinto-Díaz
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors.forename: Yhojan
authors.initials: Y
authors.lastname: Rodríguez
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Monsalve
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors.forename: Yeny
authors.initials: Y
authors.lastname: Acosta-Ampudia
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Molano-González
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors.forename: Juan-Manuel
authors.initials: JM
authors.lastname: Anaya
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia. Electronic address: heily.ramirez@urosario.edu.co.
authors.forename: Carolina
authors.initials: C
authors.lastname: Ramírez-Santana
mesh_terms: D015551:Autoimmunity / Q000235:genetics*; D020275:Guillain-Barre Syndrome / Q000453:epidemiology*; D006801:Humans; D012189:Retrospective Studies; D000071243:Zika Virus Infection / Q000150:complications*
keywords: Autoimmune tautology; Colombia; Mycoplasma pneumoniae; Polyautoimmunity; Witebsky's postulates