title: Single-nucleotide polymorphism in a local population of Trichophyton rubrum.
abstract: Trichophyton rubrum is an important causative agent of superficial mycoses worldwide. To uncover a genetic composition of a local population of this fungus, we sequenced A7C99_6411 and A7C99_6714 loci, coding for hypothetical proteins and revealed two complex genotypes, differing by a single missense mutation in each locus. One of the two A7C99_6411/6714 genotypes was not found in tinea pedis cases and demonstrated mostly longer TRS-1 elements when compared to another genotype. Thus, we present a description of nucleotide polymorphism in protein-coding loci in T. rubrum and provide evidence for ecological preferences of T. rubrum genotypes at a local scale.
authors.affiliation: Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia.
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Pchelin
authors.affiliation: Department of Epidemiology, Parasitology and Disinfectology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia.
authors.forename: Daniil V
authors.initials: DV
authors.lastname: Azarov
authors.affiliation: Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia.
authors.forename: Galina A
authors.initials: GA
authors.lastname: Chilina
authors.affiliation: Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia.
authors.forename: Kirill A
authors.initials: KA
authors.lastname: Dmitriev
authors.affiliation: Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia.
authors.forename: Natalya V
authors.initials: NV
authors.lastname: Vasilyeva
authors.affiliation: Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia.
authors.forename: Anastasia E
authors.initials: AE
authors.lastname: Taraskina
mesh_terms: D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D056426:Genetic Loci; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D014005:Tinea / Q000382:microbiology; D014249:Trichophyton / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D004271:DNA, Fungal
keywords: NTS typing; SNP; dermatophyte; epidemiology; tinea pedis