title: Impacts ofHibiscus esculentusextract on glucose and lipid profile of diabetic rats.
abstract: Introduction:Hibiscus esculentusis capable to produce various molecules including phenolic and flavonoid compounds, phytosteroids with antioxidant property. Therefore, it has the potential to show antidiabetic activities.Objectives:This study was aimed to evaluate the impacts ofHibiscus esculentusextract on glucose and lipid profile of diabetic rats. The flavonoid, flavonol and phenolic components, as well as antioxidant activity ofHibiscus esculentuswas also evaluated.Materials and Methods:In a preclinical study, 40 male Wistar rats were designated into four 10-member groups, i.e., control, diabetic control, diabeticHibiscus esculentus, and diabetic glibenclamide. The Alloxan-induced diabetic rats received extracts orally for four weeks. Then, the serum biochemical factors were measured and compared by analysis of variance (ANOVA).Results:Serum glucose, triglyceride (TG), cholesterol, and low density lipoprotein cholesterol (LDL-C) were significantly decreased and high density lipoprotein cholesterol (HDL-C) increased in diabeticHibiscus esculentusrats compared to diabetic control ones (P < 0.05).Conclusion:Improving the blood glucose and lipid profile in diabetic rats indicates thatHibiscus esculentusextract might be beneficial in diabetic patients.
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Akbari
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Shahinfard
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mirhoseini
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Hedayatollah
authors.initials: H
authors.lastname: Shirzad
authors.affiliation: Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Esfandiar
authors.initials: E
authors.lastname: Heidarian
authors.affiliation: Nickan Research Institute, Isfahan, Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Hajian
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
keywords: Diabetes mellitus; Hibiscus esculentus; Hyperglycemia; Lipid profile