title: Dopamine and dopamine receptor D1 associated with decreased social interaction.
abstract: Deficits in social interaction are hallmarks of neurological and psychiatric disorders. However, its underlying mechanism is still unclear. Here, we show that the loss of dendritic cell factor 1 (Dcf1) in the nervous system of mice induces social interaction deficiency, autism-like behaviour, and influences social interaction via the dopamine system. Dopamine receptor D1 agonist rescues this social cognition phenotype, and improves short-term plasticity. Together, this study presents a new genetic mechanism that affects social interaction and may provide a new way to improve positive social interaction and treat autism spectrum disorders.
authors.affiliation: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
authors.forename: Jieyun
authors.initials: J
authors.lastname: Shi
authors.affiliation: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
authors.forename: Rongfei
authors.initials: R
authors.lastname: Lin
authors.affiliation: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China. Electronic address: wtq@shu.edu.cn.
authors.forename: Tieqiao
authors.initials: T
authors.lastname: Wen
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000008:administration & dosage; D000818:Animals; D004298:Dopamine / Q000008:administration & dosage / Q000378:metabolism; D018491:Dopamine Agonists / Q000008:administration & dosage; D019706:Excitatory Postsynaptic Potentials; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D007398:Interpersonal Relations; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D009473:Neuronal Plasticity; D017447:Receptors, Dopamine D1 / Q000378:metabolism / Q000502:physiology*
chemical_list: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D004298:Dopamine; D018491:Dopamine Agonists; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D017447:Receptors, Dopamine D1; C000626540:Tmem59 protein, mouse
keywords: DA; DRD1; Dcf1; Social interaction