title: Glucose-Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid.
abstract: Hydrogel optical fibers are utilized for continuous glucose sensing in real time. The hydrogel fibers consist of poly(acrylamide-co-poly(ethylene glycol) diacrylate) cores functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis-diol groups of glucose enables reversible changes of the hydrogel fiber diameter. The analyses of light propagation loss allow for quantitative glucose measurements within the physiological range.
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
authors.forename: Ali K
authors.initials: AK
authors.lastname: Yetisen
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan, 430070, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
authors.forename: Afsoon
authors.initials: A
authors.lastname: Fallahi
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
authors.forename: Yunuen
authors.initials: Y
authors.lastname: Montelongo
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
authors.forename: Guillermo U
authors.initials: GU
authors.lastname: Ruiz-Esparza
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Tamayol
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
authors.forename: Yu Shrike
authors.initials: YS
authors.lastname: Zhang
authors.affiliation: Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
authors.forename: Iram
authors.initials: I
authors.lastname: Mahmood
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
authors.forename: Su-A
authors.initials: SA
authors.lastname: Yang
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
authors.forename: Ki Su
authors.initials: KS
authors.lastname: Kim
authors.affiliation: School of Engineering, University of Birmingham, Birmingham, B15 2TT, UK.
authors.forename: Haider
authors.initials: H
authors.lastname: Butt
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Biomaterials Innovation Research Center, Division of Engineering in Medicine Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|Department of Physics, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.|Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, 143-701, South Korea.
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Seok-Hyun
authors.initials: SH
authors.lastname: Yun
keywords: diagnostics; fiber optics; glucose sensing; hydrogels; light transmission