title: X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.
abstract: The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.
authors.affiliation: Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.
authors.forename: H
authors.identifier: http://orcid.org/0000-0003-2524-2201
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.
authors.forename: D R
authors.initials: DR
authors.lastname: Du Bois
authors.affiliation: Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.
authors.forename: J W
authors.initials: JW
authors.lastname: Ziller
authors.affiliation: Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.
authors.forename: J S
authors.initials: JS
authors.lastname: Nowick
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D002712:Chlorides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D047630:Depsipeptides / Q000737:chemistry* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002712:Chlorides; D047630:Depsipeptides; C000594838:teixobactin