title: Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium.
abstract: Treatment with chemotherapy, radiotherapy, or surgery that involves reproductive organs can cause impaired spermatogenesis, testosterone deficiency, and physical sexual dysfunction in male pubertal, adolescent, and young adult cancer survivors. Guidelines for surveillance and management of potential adverse effects could improve cancer survivors' health and quality of life. Surveillance recommendations vary considerably, causing uncertainty about optimum screening practices. This clinical practice guideline recommended by the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium, developed using evidence-based methodology, critically synthesises surveillance recommendations for gonadotoxicity in male childhood, adolescent, and young adult (CAYA) cancer survivors. The recommendations were developed by an international multidisciplinary panel including 25 experts in relevant medical specialties, using a consistent and transparent process. Recommendations were graded according to the strength of underlying evidence and potential benefit gained by early detection and appropriate management. The aim of the recommendations is to enhance evidence-based care for male CAYA cancer survivors. The guidelines reveal the paucity of high-quality evidence, highlighting the need for further targeted research.
authors.affiliation: Department of Paediatric and Adolescent Haematology/Oncology and Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital and Northern Institute of Cancer Research, Newcastle University, Newcastle upon Tyne, UK. Electronic address: roderick.skinner@ncl.ac.uk.
authors.forename: Roderick
authors.initials: R
authors.lastname: Skinner
authors.affiliation: Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.
authors.forename: Renee L
authors.initials: RL
authors.lastname: Mulder
authors.affiliation: Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.
authors.forename: Leontien C
authors.initials: LC
authors.lastname: Kremer
authors.affiliation: Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.affiliation: Departments of Radiation Oncology and Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Louis S
authors.initials: LS
authors.lastname: Constine
authors.affiliation: 2nd Department of Pediatrics, Semmeilweis University, Budapest, Hungary; Hungary and Johannes Kepler Universitätsklinikum, Linz, Austria.
authors.forename: Edit
authors.initials: E
authors.lastname: Bardi
authors.affiliation: Department of Medical Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, Netherlands.
authors.forename: Annelies
authors.initials: A
authors.lastname: Boekhout
authors.affiliation: Department of Paediatric Haematology, Oncology and Haemopoietic Stem Cell Transplantation, Charité-Universitätsmedizin, Berlin, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Borgmann-Staudt
authors.affiliation: Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Morven C
authors.initials: MC
authors.lastname: Brown
authors.affiliation: Kids Cancer Centre, Sydney Children's Hospital, Sydney and UNSW Medicine, Sydney, NSW, Australia.
authors.forename: Richard
authors.initials: R
authors.lastname: Cohn
authors.affiliation: Department of Paediatric Haematology and Oncology, University Hospital Muenster, Muenster, Germany.
authors.forename: Uta
authors.initials: U
authors.lastname: Dirksen
authors.affiliation: Department of Translational Medicine, Lund University, Malmö, Sweden.
authors.forename: Alexsander
authors.initials: A
authors.lastname: Giwercman
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishiguro
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Kirsi
authors.initials: K
authors.lastname: Jahnukainen
authors.affiliation: Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, USA.
authors.forename: Lisa B
authors.initials: LB
authors.lastname: Kenney
authors.affiliation: Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.
authors.forename: Jacqueline J
authors.initials: JJ
authors.lastname: Loonen
authors.affiliation: Department of Pediatrics, Division of Hematology/Oncology and Endocrinology, Emory University and Aflac Cancer Center of Children's Healthcare of Atlanta, Atlanta, GA, USA.
authors.forename: Lilian
authors.initials: L
authors.lastname: Meacham
authors.affiliation: Department of Medicine section Endocrinology, Erasmus University Medical Center Rotterdam and Pediatric Oncology, Sophia's Children's Hospital/Erasmus University Medical Center, Rotterdam, Netherlands.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Neggers
authors.affiliation: Department of Endocrinology, St George's University of London, London, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Nussey
authors.affiliation: Department of Pediatric Oncology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Petersen
authors.affiliation: Department of Urology, University of Washington, Division of Pediatric Urology, Seattle Children's Hospital, Seattle, WA, USA.
authors.forename: Margarett
authors.initials: M
authors.lastname: Shnorhavorian
authors.affiliation: Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
authors.forename: Marry M
authors.initials: MM
authors.lastname: van den Heuvel-Eibrink
authors.affiliation: Department of Pediatric Endocrinology, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Utrecht, Netherlands.
authors.forename: Hanneke M
authors.initials: HM
authors.lastname: van Santen
authors.affiliation: University of Edinburgh and Royal Hospital for Sick Children, Edinburgh, UK.
authors.forename: William H B
authors.initials: WH
authors.lastname: Wallace
authors.affiliation: Departments of Oncology and Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Green
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects*; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D007391:International Cooperation; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D011159:Population Surveillance; D017410:Practice Guidelines as Topic / Q000592:standards*; D018570:Risk Assessment; D017741:Survivors; D013733:Testicular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D055815:Young Adult