title: Protective Effects of Tyrosol against LPS-Induced Acute Lung Injury via Inhibiting NF-κB and AP-1 Activation and Activating the HO-1/Nrf2 Pathways.
abstract: Tyrosol (Tyr) is a natural antioxidant that displays anti-oxidant and anti-inflammatory properties. The present study aimed to investigate the effect and mechanism of Tyr on lipopolysaccharide (LPS)-induced acute lung injury (ALI). In a mouse model, we found that pretreatment with Tyr significantly improved survival rate, attenuated lung permeability, ameliorated histopathological alterations, reduced expression of the inflammatory mediators and improved expression of the antioxidant enzyme. Further study revealed that Tyr markedly inhibited nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) activation at both in vivo and in vitro levels. To investigate the underlying mechanism, we examined the impact of Tyr on the heme oxygenase (HO)-1/nuclear factor erythroid-2 related factor 2 (Nrf2) pathway in vivo and in vitro. The results showed that Tyr significantly improved the expression of HO-1 and the activation of Nrf2. This study offers novel evidence to support the efficacy of Tyr against ALI, which helps to clarify the underlying causes of the therapeutic effects behind Tyr.
authors.affiliation: Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University.
authors.forename: Wen-Chen
authors.initials: WC
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University.
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Xia
authors.affiliation: Department of Thoracic Surgery, Tianjin First Center Hospital.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Nursing, Fourth Military Medical University.
authors.forename: Xiang-Ni
authors.initials: XN
authors.lastname: Su
authors.affiliation: Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University.
authors.forename: Jia-Kuan
authors.initials: JK
authors.lastname: Chen
authors.affiliation: Department of Histology and Embryology, Fourth Military Medical University.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D055371:Acute Lung Injury / Q000517:prevention & control*; D000818:Animals; D002478:Cells, Cultured; D051547:Heme Oxygenase-1 / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051267:NF-E2-Related Factor 2 / Q000502:physiology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D009195:Peroxidase / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors*
chemical_list: D008070:Lipopolysaccharides; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495636:Nfe2l2 protein, mouse; D018808:Transcription Factor AP-1; C011867:4-hydroxyphenylethanol; D009195:Peroxidase; D051547:Heme Oxygenase-1; D010626:Phenylethyl Alcohol
keywords: activator protein (AP)-1; acute lung injury (ALI); heme oxygenase (HO)-1; nuclear factor (NF)-κB; nuclear factor erythroid-2 related factor 2(Nrf2); tyrosol(Tyr)