title: Application of optogenetics-mediated motor cortex stimulation in the treatment of chronic neuropathic pain.
abstract: Motor cortex stimulation provides an alternate approach for intractable pain treatment. Optogenetic manipulation can produce gain- or loss-of-function in specific type of cells following light application. This state-of-the-art technology may be used in motor cortex stimulation to produce circuit-specific neuromodulation and regulate neuronal activities in motor cortex, thereby treating pain in the clinic. Here, we discuss the principle of optogenetics-mediated motor cortex stimulation and discuss its potential application in the treatment of chronic neuropathic pain.
authors.affiliation: Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, Dallas, Texas, USA; Department of Physiology, Zhengzhou University School of Medicine, Zhengzhou, Henan, China.
authors.forename: Sufang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, Dallas, Texas, USA; Center for Craniofacial Research and Diagnosis, Texas A&M University Baylor College of Dentistry, Dallas, Texas, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Tao