title: Paroxysmal Hypertension Induced by an Insulinoma.
abstract: Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible etiology of hypertension induced by an insulinoma is catecholamine release in response to hypoglycemia, which may cause acute hypertension through activation of the sympatho-adrenal system. This case implies that sustained hyperinsulinemia due to insulinoma can be functionally linked to the induction of paroxysmal hypertension.
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Harada
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hanayama
authors.forename: Kou
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Masaya
authors.initials: M
authors.lastname: Iwamuro
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hagiya
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Yoshida
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
mesh_terms: D000368:Aged; D003221:Confusion / Q000209:etiology / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D007003:Hypoglycemia / Q000209:etiology / Q000378:metabolism; D007340:Insulinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009422:Nervous System Diseases / Q000209:etiology; D009638:Norepinephrine / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D009638:Norepinephrine; D004837:Epinephrine