title: Psoriasis and Risk of Celiac Disease: A Systematic Review and Meta-analysis.
abstract: OBJECTIVE
  The possible association between psoriasis and celiac disease (CD) has long been observed, but epidemiologic studies attempting to characterize this association have yielded inconclusive results. This meta-analysis was conducted with the aims to summarize all available data.
  
  
  METHODS
  We conducted a systematic review and meta-analysis of observational studies that reported relative risk, hazard ratio, odds ratio (OR), or standardized incidence ratio with 95% confidence interval (CI) comparing the risk of CD in patients with psoriasis versus participants without psoriasis. Pooled risk ratio and 95% CI were calculated using random-effect, generic inverse-variance methods of DerSimonian and Laird.
  
  
  RESULTS
  Four retrospective cohort studies with 12,912 cases of psoriasis and 24,739 comparators were included in this meta-analysis. The pooled analysis demonstrated a significantly higher risk of CD among patients with psoriasis compared with participants without psoriasis with the pooled OR of 3.09 (95% CI, 1.92-4.97).
  
  
  CONCLUSIONS
  Most primary studies reported unadjusted estimated effect, raising a concern over confounders.
  
  
  CONCLUSIONS
  Our meta-analysis demonstrated an approximately 3-fold increased risk of CD among patients with psoriasis.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
authors.forename: Karn
authors.initials: K
authors.lastname: Wijarnpreecha
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
authors.forename: Wonngarm
authors.initials: W
authors.lastname: Kittanamongkolchai
keywords: Celiac disease; epidemiology; psoriasis; risk factor