title: Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases.
abstract: We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects ofGtf2iexpression level as well as its relationship with neuropsychiatric disorders.
authors.affiliation: Department of Neuroplasticity, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. yoshirai@shinshu-u.ac.jp.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Shirai
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. liwd@sjtu.edu.cn.|Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan. liwd@sjtu.edu.cn.
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Neuroplasticity, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. suzukit@shinshu-u.ac.jp.|Department of Biological Sciences for Intractable Neurological Diseases, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan. suzukit@shinshu-u.ac.jp.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D020121:5' Untranslated Regions; D017398:Alternative Splicing; D000818:Animals; D056915:DNA Copy Number Variations; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism*; D009422:Nervous System Diseases / Q000235:genetics* / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013570:Synaptic Membranes / Q000378:metabolism*; D019473:Transcription Factors, TFII / Q000235:genetics* / Q000378:metabolism*
chemical_list: D020121:5' Untranslated Regions; D012333:RNA, Messenger; D019473:Transcription Factors, TFII
keywords: 5′UTR; alternative splicing; local protein synthesis; neuropsychiatric disorders; postsynaptic density; synapse; synaptic plasticity; transcription factor