title: Osteopontin: Relation between Adipose Tissue and Bone Homeostasis.
abstract: Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy.
authors.forename: Carolina
authors.identifier: 0000-0002-3170-1155
authors.initials: C
authors.lastname: De Fusco
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy.
authors.forename: Antonietta
authors.initials: A
authors.lastname: Messina
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Monda
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy; Department of Medicine, University of Padua, Padua, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Viggiano
authors.affiliation: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
authors.forename: Fiorenzo
authors.identifier: 0000-0003-1274-0332
authors.initials: F
authors.lastname: Moscatelli
authors.affiliation: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Valenzano
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Esposito
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy.
authors.forename: Chieffi
authors.identifier: 0000-0002-1478-784X
authors.initials: C
authors.lastname: Sergio
authors.affiliation: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cibelli
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy.
authors.forename: Marcellino
authors.identifier: 0000-0002-7184-218X
authors.initials: M
authors.lastname: Monda
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
authors.forename: Giovanni
authors.identifier: 0000-0002-0011-867X
authors.initials: G
authors.lastname: Messina