title: FOXA1 in HPV associated carcinomas: Its expression in carcinomas of the head and neck and of the uterine cervix.
abstract: FOXA1 is a major transcription factor involved in the action of human papilloma virus (HPV). However, it has been never studied in HPV-associated tumors.
  
  
  
  To investigate its expression in cervical and head and neck tumors.
  
  
  
  63 cervical carcinomas/dysplasias and 152 head and neck squamous cell carcinomas (HNSCC) were immunohistochemically studied for the expression of FOXA1.
  
  
  
  63.1% of cervical SCC and 40.7% of endocervical adenocarcinomas strongly expressed FOXA1. Most (90%) pre-invasive lesions (CIN3 and in situ adenocarcinomas) strongly expressed FOXA1 and this difference from invasive lesions was statistically significant (p=0.005). No association with clinicopathological factors was found. 51.3% of HNSCC expressed FOXA1. In these tumors, FOXA1 expression was associated with the non-keratinizing morphology but not with the HPV/p16 status neither other clinicopathological features. Of normal structures, salivary glands, endocervical glands and basal/parabasal cell layer of squamous epithelium of both uterine cervix and head and neck mucosa, all strongly expressed FOXA1.
  
  
  
  FOXA1 is expressed by basal cells of squamous epithelium, pre-invasion lesions of the uterine cervix and the head/neck and almost half invasive cervical and head/neck carcinomas, supporting its possible implication in HPV pathogenesis.
authors.affiliation: Department of Pathology, North Hospital, University Hospital of St-Etienne, France. Electronic address: gakarpath@yahoo.gr.
authors.forename: Georgia
authors.initials: G
authors.lastname: Karpathiou
authors.affiliation: Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Da Cruz
authors.affiliation: Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Casteillo
authors.affiliation: Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Mousa
authors.initials: M
authors.lastname: Mobarki
authors.affiliation: Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Dumollard
authors.affiliation: Department of Obstetrics and Gynecology, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Celine
authors.initials: C
authors.lastname: Chauleur
authors.affiliation: Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Forest
authors.affiliation: Department of Head and Neck Surgery, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Prades
authors.affiliation: Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Peoc'h
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology*; D016889:Endometrial Neoplasms / Q000235:genetics / Q000821:virology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000821:virology; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000235:genetics / Q000473:pathology; D000077195:Squamous Cell Carcinoma of Head and Neck; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000821:virology
chemical_list: C496499:FOXA1 protein, human; D051541:Hepatocyte Nuclear Factor 3-alpha
keywords: Carcinogenesis; Cervix; Dysplasia; FOXA1; HPV; Oropharynx; Tumor