title: Ent-Abietanoids Isolated from Isodon serra.
abstract: Four newent-abietane diterpenoids, along with four known ones were isolated from the aerial parts ofIsodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3and4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound1showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50= 1.8 μM) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. wanjun@imm.ac.cn.|Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. wanjun@imm.ac.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. jianghuayi@mail.kib.ac.cn.|Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. jianghuayi@mail.kib.ac.cn.
authors.forename: Hua-Yi
authors.initials: HY
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. tangjianwei@mail.kib.ac.cn.|Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. tangjianwei@mail.kib.ac.cn.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. lixingren@mail.kib.ac.cn.|Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. lixingren@mail.kib.ac.cn.
authors.forename: Xing-Ren
authors.initials: XR
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. duxue@mail.kib.ac.cn.
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. liyanb@mail.kib.ac.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. hdsun@mail.kib.ac.cn.
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. pujianxin@mail.kib.ac.cn.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D009569:Nitric Oxide
keywords: Isodon serra; anti-inflammation; cytotoxicity; ent-abietane diterpenoids