title: p27kip1: An all-round tumor suppressor.
abstract: Our recent study has uncovered an additional mechanism by which the cell cycle inhibitor p27kip1 controls cell proliferation. Through its effect on the activity of the microtubule destabilizing protein Stathmin, p27kip1 modulates full H-Ras activation and, as a consequence, the MAPK signaling cascade. This regulatory mechanism influences the cell cyclein vitroand tissue and/or organ growth in mice, in vivo and, when unbalanced, may lead to uncontrolled proliferation and tumor onset.
authors.affiliation: Division of Experimental Oncology 2, Department of Translational Research, CRO Aviano, National Cancer Institute , Aviano, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Belletti
authors.affiliation: Division of Experimental Oncology 2, Department of Translational Research, CRO Aviano, National Cancer Institute , Aviano, Italy.
authors.forename: Linda
authors.initials: L
authors.lastname: Fabris
authors.affiliation: Division of Experimental Oncology 2, Department of Translational Research, CRO Aviano, National Cancer Institute , Aviano, Italy.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Baldassarre
keywords: Cell cycle; External stimulus; Ras; Stathmin; microtubules; p27kip1