title: Psoriasis and comorbid diseases: Implications for management.
abstract: As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chronic kidney disease, inflammatory bowel disease, hepatic disease, certain malignancies, infections, and mood disorders. Recognizing the comorbid disease burden of psoriasis is essential for ensuring comprehensive care of patients with psoriasis. The clinical implications of the comorbid diseases that are associated with psoriasis and recommendations for clinical management are reviewed in this article.
authors.affiliation: Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: Junko.Takeshita@uphs.upenn.edu.
authors.forename: Junko
authors.initials: J
authors.lastname: Takeshita
authors.affiliation: Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Sungat
authors.initials: S
authors.lastname: Grewal
authors.affiliation: London School of Hygiene and Tropical Medicine and St. John's Institute of Dermatology, London, United Kingdom.
authors.forename: Sinéad M
authors.initials: SM
authors.lastname: Langan
authors.affiliation: National Heart, Lung and Blood Institute, Bethesda, Maryland.
authors.forename: Nehal N
authors.initials: NN
authors.lastname: Mehta
authors.affiliation: Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Alexis
authors.initials: A
authors.lastname: Ogdie
authors.affiliation: Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia.
authors.forename: Abby S
authors.initials: AS
authors.lastname: Van Voorhees
authors.affiliation: Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Gelfand
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000517:prevention & control; D015897:Comorbidity; D000075202:Contraindications; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007239:Infections / Q000175:diagnosis* / Q000453:epidemiology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000453:epidemiology; D008107:Liver Diseases / Q000453:epidemiology; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology / Q000628:therapy; D011565:Psoriasis / Q000188:drug therapy* / Q000453:epidemiology* / Q000628:therapy; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha
keywords: Crohn's disease; cardiovascular disease; chronic kidney disease; comorbidities; depression; infection; lymphoma; metabolic syndrome; nonalcoholic fatty liver disease; psoriasis; psoriatic arthritis; screening; vaccination