title: Herpes Simplex Virus in the Neonate.
abstract: Neonatal herpes simplex virus (HSV) disease is a serious, life-threatening condition that should be considered in neonates with fever, vesicular rash, culture negative sepsis, and/or seizure activity. Because signs and symptoms of neonatal HSV may closely resemble those of bacterial sepsis, a thorough history and appropriate testing are imperative to accurately confirm the diagnosis. Failure to treat vesicular lesions from HSV in the neonate leads to an approximate 75% chance of progression to disseminated disease and/or meningoencephalitis. Therefore, prompt recognition of symptoms and institution of treatment pending results of the investigation are imperative to minimize the high rates of morbidity and mortality associated with this diagnosis. [Pediatr Ann. 2017;46(2):e42-e46.].
authors.forename: Amy
authors.initials: A
authors.lastname: Wang
authors.forename: Julie
authors.initials: J
authors.lastname: Wohrley
authors.forename: Julia
authors.initials: J
authors.lastname: Rosebush
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy; D018139:Simplexvirus; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir