title: Ensemble Neuron Tracer for 3D Neuron Reconstruction.
abstract: Tracing of neuron paths is important in neuroscience. Recent studies have shown that it is possible to segment and reconstruct three-dimensional morphology of axons and dendrites using fully automatic neuron tracing methods. A specific tracer may be better than others for a specific dataset, but another tracer could perform better for some other datasets. Ensemble of learners is an effective way to improve learning accuracy in machine learning. We developed automatic ensemble neuron tracers, which consistently perform well on 57 datasets of 5 species collected from 7 laboratories worldwide. Quantitative evaluation based on the data generated by human annotators shows that the proposed ensemble tracers are valuable for 3D neuron tracing and can be widely applied to different datasets.
authors.affiliation: Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan. cweiwang@mail.ntust.edu.tw.|NTUST Center of Computer Vision and Medical Imaging, National Taiwan University of Science and Technology, Taipei, Taiwan. cweiwang@mail.ntust.edu.tw.
authors.forename: Ching-Wei
authors.identifier: http://orcid.org/0000-0001-9992-6863
authors.initials: CW
authors.lastname: Wang
authors.affiliation: NTUST Center of Computer Vision and Medical Imaging, National Taiwan University of Science and Technology, Taipei, Taiwan.|Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.|NTUST Center of Computer Vision and Medical Imaging, National Taiwan University of Science and Technology, Taipei, Taiwan.
authors.forename: Hilmil
authors.initials: H
authors.lastname: Pradana
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, 98103, USA.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, 98103, USA.
authors.forename: Hanchuan
authors.initials: H
authors.lastname: Peng
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000166:cytology / Q000000981:diagnostic imaging; D016208:Databases, Factual; D003712:Dendrites / Q000648:ultrastructure; D001330:Electronic Data Processing; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure
keywords: 3D neuron reconstruction; Ensemble neuron tracer