title: Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study.
abstract: This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular aging in apparently healthy individuals. During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular aging in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity. The secondary endpoints were assessment of metabotrophic blood biomarkers associated with cellular aging, which included cortisol,β-endorphin, IL-6, BDNF, and sirtuin-1. After 12 weeks of YMLI, there were significant improvements in both the cardinal biomarkers of cellular aging and the metabotrophic biomarkers influencing cellular aging compared to baseline values. The mean levels of 8-OH2dG, ROS, cortisol, and IL-6 were significantly lower and mean levels of TAC, telomerase activity,β-endorphin, BDNF, and sirtuin-1 were significantly increased (all valuesp< 0.05) post-YMLI. The mean level of telomere length was increased but the finding was not significant (p= 0.069). YMLI significantly reduced the rate of cellular aging in apparently healthy population.
authors.affiliation: Lab for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Tolahunase
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Sagar
authors.affiliation: Lab for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Rima
authors.identifier: 0000-0002-4920-0789
authors.initials: R
authors.lastname: Dada
mesh_terms: D000328:Adult; D000368:Aged; D016922:Cellular Senescence; D004249:DNA Damage; D005260:Female; D006801:Humans; D008297:Male; D019122:Meditation; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D017382:Reactive Oxygen Species; D016615:Telomere; D015013:Yoga
chemical_list: D017382:Reactive Oxygen Species