title: Both sides of the same coin: Rac1 splicing regulating by EGF signaling.
abstract: EGF, a well-studied mitogen for cancer cells, is revealed to induce an E3 ubiquitin ligase adaptor SPSB1, which recruits the Elongin B/C-Collin complex to trigger ubiquitylation of the negative splicing regulator hnRNP A1. This event is synergized with EGF-activated SR proteins to alter alternative splicing of a key small GTPase Rac1 to enhance cell migration, highlighting converging EGF signals on both negative and positive splicing regulators to jointly promote a key cancer pathway.
authors.affiliation: Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Fu
mesh_terms: D017398:Alternative Splicing; D002465:Cell Movement; D004815:Epidermal Growth Factor; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D054875:Ubiquitination
chemical_list: D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D004815:Epidermal Growth Factor