title: Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas.
abstract: Survival outcomes following multimodal treatment of operable oesophageal and gastrooesophageal cancer remain disappointingly poor. Although an appreciation of the impact of both tumour location and histological subtype is now shaping the design of clinical trials, there has been a lack of consensus of the optimal neoadjuvant treatment strategy. This update article will review recent advances in the use of both neoadjuvant chemotherapy and chemoradiotherapy. The emerging role of PET imaging to direct appropriate neoadjuvant treatment regimens and the additive benefit of biological agents are also discussed.
authors.affiliation: Cardiff University, Cardiff, CF10 3XQ, UK. curries@doctors.org.uk.|Department of Clinical Oncology, Velindre Cancer Centre, Cardiff, UK. curries@doctors.org.uk.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Cox
authors.affiliation: Department of Clinical Oncology, Oxford University NHS Trust, Oxford, UK.
authors.forename: Sean M
authors.initials: SM
authors.lastname: O'Cathail
authors.affiliation: Library Services, Velindre NHS Trust, Cardiff, UK.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Coles
authors.affiliation: Department of Clinical Oncology, Velindre Cancer Centre, Cardiff, UK.
authors.forename: Tom
authors.initials: T
authors.lastname: Crosby
authors.affiliation: MRC/CRUK Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
authors.forename: Somnath
authors.initials: S
authors.lastname: Mukherjee
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D059248:Chemoradiotherapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D004943:Esophagogastric Junction / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D020360:Neoadjuvant Therapy
keywords: Adenocarcinoma; Chemoradiotherapy; Chemotherapy; Gastrooesophageal junction; Neoadjuvant; Oesophagus; Squamous cell carcinoma