title: Synchronous carcinosarcoma of the uterine cervix with adenoid basal carcinoma and cervical intraepithelial neoplasia III: A case report and literature review.
abstract: Carcinosarcoma and adenoid basal carcinoma (ABC) are both rare lesions in uterine cervix. There were only 5 cases of cervical carcinosarcoma combined with ABC and/without cervical intraepithelial neoplasia (CIN) reported in English literature. These limited studies showed that there was a strong association between HPV, carcinosarcoma, ABC and CIN, suggesting a common etiology for these lesions. Here, we present the case of a 65-year-old woman with cervical carcinosarcoma combined with ABC and CIN III. However, HPV-16, 18, 31 and 33 was negative in the cervical carcinosarcoma tissue by in situ hybridization detection. It indicated that there might be other subtype of HPV involved, or, HPV might play a role in some but not all cervical carcinosarcomas.
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Hanrui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Ziyin
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: xuel@mail.sysu.edu.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
mesh_terms: D000234:Adenoids / Q000473:pathology; D000368:Aged; D002296:Carcinosarcoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000821:virology
keywords: Adenoid basal carcinoma; Carcinosarcoma; Cervical intraepithelial neoplasia; Human papillomavirus