title: Maternal Vitamin D Status in the Late Second Trimester and the Risk of Severe Preeclampsia in Southeastern China.
abstract: The association between maternal vitamin D deficiency and the risk of severe preeclampsia is still debated. In the present study, we aimed to evaluate vitamin D status in Chinese pregnant women and investigate its correlation with the odds of developing severe preeclampsia. A cohort study was performed on 13,806 pregnant women who routinely visited the antenatal care clinics and subsequently delivered at the Wuxi Maternity and Child Health Hospital. All the subjects in the cohort had their serum 25-hydroxyvitamin D (25(OH)D) concentrations measured during pregnancy. A high prevalence of maternal vitamin D deficiency (25(OH)D < 50 nmol/L) was found. Pregnant women who had different BMIs before pregnancy had significantly different serum concentrations of 25(OH)D. There was also a significant difference in the serum 25(OH)D concentration among pregnant women of different ages. The serum 25(OH)D concentration was significantly lower in pregnant women who subsequently developed severe preeclampsia compared with those who did not. Maternal vitamin D deficiency at 23-28 weeks of gestation was strongly associated with increased odds for severe preeclampsia after adjusting for relevant confounders (adjusted OR, 3.16; 95% CI, 1.77-5.65). Further studies are required to investigate whether vitamin D supplementation would reduce the risk of severe preeclampsia and improve pregnancy outcomes.
authors.affiliation: Department of Obstetrics, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. zhaoxin63147@163.com.|Centre for Reproductive Medicine, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. zhaoxin63147@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Centre for Reproductive Medicine, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. wfangruix@163.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Fang
authors.affiliation: Department of Newborn, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. yurenqiang553@163.com.
authors.forename: Renqiang
authors.initials: R
authors.lastname: Yu
authors.affiliation: Central Laboratory, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. chendaozhen@163.com.
authors.forename: Daozhen
authors.initials: D
authors.lastname: Chen
authors.affiliation: Central Laboratory, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. chalange@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China. jianpingxiaowx@163.com.
authors.forename: Jianping
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002118:Calcium / Q000097:blood; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D016015:Logistic Models; D009752:Nutritional Status; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second / Q000097:blood*; D015995:Prevalence; D012307:Risk Factors; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D014807:Vitamin D; D002118:Calcium
keywords: pregnant women; serum 25(OH)D; severe preeclampsia; vitamin D status