title: Association of serum leptin with serum C-reactive protein in hemodialysis patients.
abstract: Introduction:Recent investigations have shown that leptin is cleared principally by the kidney.Objectives:To examine whether and how in patients on hemodialysis the level of C-reactive protein level correlate with serum leptin.Patients and Methods:The total patients were 36. The mean patients' age were 46 (16) years. The median length of the time patients were on hemodialysis were 19 months.Results:The mean serum C-reactive protein was 8.7 (6.6) mg/l (median: 8 mg/l). The mean serum leptin was 9.4 (14) ng/ml (median: 5.75 ng/ml). In this study we found a significant inverse correlation of serum leptin with serum C-reactive protein (r= -0.57, p= 0.041) was seen.Conclusion:Our data supports, the positive effect of leptin on nutrition and support the theory of protective effects (reverse epidemiology) of leptin in hemodialysis patients.
authors.affiliation: Section of Hemodialysis, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Rastegari
authors.affiliation: Section of Hemodialysis, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
keywords: C-reactive protein; End-stage renal failure; Hemodialysis; Leptin