title: Adsorption of Amino Acids and Glutamic Acid-Based Surfactants on Imogolite Clays.
abstract: Aluminum oxide surfaces are of utmost interest in different biotech applications, in particular for their use as adjuvants (i.e., booster of the immune response against infectious agents in vaccines production). In this framework, imogolite clays combine the chemical flexibility of an exposed alumina surface with 1D nanostructure. This work reports on the interaction between amino acids and imogolite, using turbidimetry, ζ-potential measurements, and Fourier transform infrared spectroscopy as main characterization tools. Amino acids with different side chain functional groups were investigated, showing that glutamic acid (Glu) has the strongest affinity for the imogolite surface. This was exploited to prepare a composite material made of a synthetic surfactant bearing a Glu polar head and a hydrophobic C12alkyl tail, adsorbed onto the surface of imogolite. The adsorption of a model drug (rhodamine B isothiocyanate) by the hybrid was evaluated both in water and in physiological saline conditions. The findings of this paper suggest that the combination between the glutamate headgroup and imogolite represents a promising platform for the fabrication of hybrid nanostructures with tailored functionalities.
authors.affiliation: Department of Chemistry "Ugo Schiff" and CSGI, University of Florence , via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bonini
authors.affiliation: Department of Chemistry "Ugo Schiff" and CSGI, University of Florence , via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Gabbani
authors.affiliation: Department of Chemistry "Ugo Schiff" and CSGI, University of Florence , via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Del Buffa
authors.affiliation: Department of Chemistry "Ugo Schiff" and CSGI, University of Florence , via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Ridi
authors.affiliation: Department of Chemistry "Ugo Schiff" and CSGI, University of Florence , via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Piero
authors.identifier: 0000-0003-1312-8700
authors.initials: P
authors.lastname: Baglioni
authors.affiliation: Department of Chemistry and Chemical Engineering, Chalmers University of Technology , 41296 Göteborg, Sweden.|Vinn Excellence Center SuMo Biomaterials, Chalmers University of Technology , 41296 Göteborg, Sweden.
authors.forename: Romain
authors.initials: R
authors.lastname: Bordes
authors.affiliation: Department of Chemistry and Chemical Engineering, Chalmers University of Technology , 41296 Göteborg, Sweden.
authors.forename: Krister
authors.initials: K
authors.lastname: Holmberg
mesh_terms: D000327:Adsorption; D000538:Aluminum Silicates / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D000077215:Clay; D018698:Glutamic Acid / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry; D010316:Particle Size; D012235:Rhodamines / Q000737:chemistry; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D000596:Amino Acids; D017879:Isothiocyanates; D012235:Rhodamines; D013501:Surface-Active Agents; C049037:aluminosilicate; C037152:isothiocyanic acid; D018698:Glutamic Acid; C029773:rhodamine B; D000077215:Clay