title: A Biocompatible Colorimetric Triphenylamine- Dicyanovinyl Conjugated Fluorescent Probe for Selective and Sensitive Detection of Cyanide Ion in Aqueous Media and Living Cells.
abstract: A colorimetric and turn-on fluorescent probe1bearing triphenylamine-thiophene and dicyanovinyl groups has been synthesized and used to detect cyanide anion via a nucleophilic addition reaction. Probe1exhibited prominent selectivity and sensitivity towards CN-in aqueous media, even in the presence of other anions such as S2-, HS-, SO₃2-, S₂O₃2-, S₂O₈2-, I-, Br-, Cl-, F-, NO₂-, N₃-, SO₄2-, SCN-, HCO₃-, CO₃2-and AcO-. Moreover, a low detection limit (LOD, 51 nM) was observed. In addition, good cell membrane permeability and low cytotoxicity to HeLa cells were also observed, suggesting its promising potential in bio-imaging.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. Zhengzihua14@mails.ucas.ac.cn.|University of Chinese Academy of Sciences, Beijing 100049, China. Zhengzihua14@mails.ucas.ac.cn.
authors.forename: Zi-Hua
authors.initials: ZH
authors.lastname: Zheng
authors.affiliation: Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China. 18280127765@163.com.
authors.forename: Zhi-Ke
authors.initials: ZK
authors.lastname: Li
authors.affiliation: Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China. linjsong_scu@163.com.
authors.forename: Lin-Jiang
authors.initials: LJ
authors.lastname: Song
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. wqw@cioc.ac.cn.
authors.forename: Qi-Wei
authors.initials: QW
authors.lastname: Wang
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. qfhuang@cioc.ac.cn.
authors.forename: Qing-Fei
authors.initials: QF
authors.lastname: Huang
authors.affiliation: Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China. yangli@scu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D003124:Colorimetry; D003486:Cyanides; D005456:Fluorescent Dyes; D006367:HeLa Cells; D006801:Humans; D013050:Spectrometry, Fluorescence
chemical_list: D003486:Cyanides; D005456:Fluorescent Dyes
keywords: biocompatible; cell imaging; colorimetric assay; cyanide anion; dicyanovinyl