title: Diagnostic performance of T1and T2mapping to detect intramyocardial hemorrhage in reperfused ST-segment elevation myocardial infarction (STEMI) patients.
abstract: To investigate the performance of T1and T2mapping to detect intramyocardial hemorrhage (IMH) in ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI).
  
  
  
  Fifty STEMI patients were prospectively recruited between August 2013 and July 2014 following informed consent. Forty-eight patients completed a 1.5T cardiac magnetic resonance imaging (MRI) with native T1, T2, and T2* maps at 4 ± 2 days. Receiver operating characteristic (ROC) analyses were performed to assess the performance of T1and T2to detect IMH.
  
  
  
  The mean age was 59 ± 13 years old and 88% (24/48) were male. In all, 39 patients had interpretable T2* maps and 26/39 (67%) of the patients had IMH ( T2* <20 msec on T2* maps). Both T1and T2values of the hypointense core within the area-at-risk (AAR) performed equally well to detect IMH (T1maps AUC 0.86 [95% confidence interval [CI] 0.72-0.99] versus T2maps AUC 0.86 [95% CI 0.74-0.99]; P = 0.94). Using the binary assessment of presence or absence of a hypointense core on the maps, the diagnostic performance of T1and T2remained equally good (T1AUC 0.87 [95% CI 0.73-1.00] versus T2AUC 0.85 [95% CI 0.71-0.99]; P = 0.90) with good sensitivity and specificity (T1: 88% and 85% and T2: 85% and 85%, respectively).
  
  
  
  The presence of a hypointense core on the T1and T2maps can detect IMH equally well and with good sensitivity and specificity in reperfused STEMI patients and could be used as an alternative when T2* images are not acquired or are not interpretable.
  
  
  
  2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:877-886.
authors.affiliation: Hatter Cardiovascular Institute, Institute of Cardiovascular Science University College London, UK.|Barts Heart Centre, St Bartholomew's Hospital, London, UK.|National Heart Research Institute Singapore, National Heart Centre Singapore.
authors.forename: Heerajnarain
authors.identifier: 0000-0002-1985-1783
authors.initials: H
authors.lastname: Bulluck
authors.affiliation: Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Stefania
authors.initials: S
authors.lastname: Rosmini
authors.affiliation: Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Amna
authors.initials: A
authors.lastname: Abdel-Gadir
authors.affiliation: Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Anish N
authors.initials: AN
authors.lastname: Bhuva
authors.affiliation: Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Treibel
authors.affiliation: Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Marianna
authors.initials: M
authors.lastname: Fontana
authors.affiliation: Heart Failure and Inherited Cardiac Diseases Unit Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, Manuel de Falla, Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Gonzalez-Lopez
authors.affiliation: Hatter Cardiovascular Institute, Institute of Cardiovascular Science University College London, UK.|National Institute of Health Research University College London Hospitals Biomedical Research Centre, UK.|Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Manish
authors.initials: M
authors.lastname: Ramlall
authors.affiliation: Hatter Cardiovascular Institute, Institute of Cardiovascular Science University College London, UK.|National Institute of Health Research University College London Hospitals Biomedical Research Centre, UK.|Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Hamarneh
authors.affiliation: National Institute of Health Research University College London Hospitals Biomedical Research Centre, UK.|Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Sirker
authors.affiliation: Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Anna S
authors.initials: AS
authors.lastname: Herrey
authors.affiliation: Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Manisty
authors.affiliation: Hatter Cardiovascular Institute, Institute of Cardiovascular Science University College London, UK.|National Institute of Health Research University College London Hospitals Biomedical Research Centre, UK.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Yellon
authors.affiliation: National Institute of Health Research University College London Hospitals Biomedical Research Centre, UK.|Barts Heart Centre, St Bartholomew's Hospital, London, UK.
authors.forename: James C
authors.initials: JC
authors.lastname: Moon
authors.affiliation: Hatter Cardiovascular Institute, Institute of Cardiovascular Science University College London, UK.|National Institute of Health Research University College London Hospitals Biomedical Research Centre, UK.|Barts Heart Centre, St Bartholomew's Hospital, London, UK.|Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
mesh_terms: D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006470:Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000628:therapy*; D015425:Myocardial Reperfusion; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: 
  T2* mapping; ST-segment elevation myocardial infarction; T1 mapping; T2 mapping; intramyocardial hemorrhage; microvascular obstruction