title: Subclinical Decrease in Myocardial Function in Asymptomatic Infants of Diabetic Mothers: A Tissue Doppler Study.
abstract: Infants of diabetic mothers (IDMs) with hypertrophic cardiomyopathy are recognized to have impaired myocardial performance, but less is known about ventricular function in IDMs without hypertrophy. We hypothesized that in asymptomatic newborns with normal two-dimensional echocardiographic evaluations, pulsed wave tissue Doppler imaging (TDI) would suggest a subclinical decrease in the cardiac function of IDMs compared to infants of non-diabetics (nIDMs). This is a retrospective cohort study of asymptomatic neonates ≥36 weeks gestation, at 0-7 days of life, with normal standard echocardiograms. Systolic (S'), early diastolic (E'), and late diastolic (A') TDI velocities were measured at the mitral valve (MV) annulus, basal interventricular septum (IVS), and tricuspid valve (TV) annulus, and averaged from three consecutive cardiac cycles. Demographic, perinatal, and echocardiographic variables were compared between IDM and nIDM groups. Of 631 subjects, 75 IDMs were identified. The mean gestational age of the entire cohort was 39.33 weeks (±1.26), birth weight 3.44 kg (±0.56), and body surface area (BSA) 0.21 m2(±0.02). IDMs had significantly greater birth weight and BSA, lower gestational age, older maternal age, and higher incidence of maternal obesity and hypertension than nIDMs (p < 0.001). On multivariable analysis, IDMs had significantly lower S' (p ≤ 0.03) and E' (p < 0.001) velocities, and higher E/E' ratios (p < 0.001) at the MV, IVS, and TV than nIDMs. In asymptomatic newborn IDMs without cardiac hypertrophy, pulsed wave TDI suggests a subclinical decrease in systolic and diastolic myocardial function compared to nIDMs.
authors.affiliation: Division of Pediatric Cardiology, Cohen Children's Medical Center at Northwell Health, 269-01 76th Ave, Suite 139, New Hyde Park, New York, NY, 11040, USA.
authors.forename: Jenny E
authors.initials: JE
authors.lastname: Zablah
authors.affiliation: Division of Pediatric Cardiology, Cohen Children's Medical Center at Northwell Health, 269-01 76th Ave, Suite 139, New Hyde Park, New York, NY, 11040, USA.
authors.forename: Dorota
authors.initials: D
authors.lastname: Gruber
authors.affiliation: Department of Biostatistics, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York, NY, 11030, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Stoffels
authors.affiliation: Department of Biology, City College of New York, 160 Convent Ave, New York, NY, 10031, USA.
authors.forename: Estefania G
authors.initials: EG
authors.lastname: Cabezas
authors.affiliation: Division of Pediatric Cardiology, Cohen Children's Medical Center at Northwell Health, 269-01 76th Ave, Suite 139, New Hyde Park, New York, NY, 11040, USA. dhayes2@northwell.edu.
authors.forename: Denise A
authors.initials: DA
authors.lastname: Hayes
mesh_terms: D000328:Adult; D048909:Diabetes Complications / Q000150:complications / Q000503:physiopathology; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009206:Myocardium; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D012189:Retrospective Studies; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*
keywords: Cardiomyopathy; Echocardiogram; Gestational diabetes; Infant of diabetic mother; Myocardial function; Tissue Doppler imaging