title: Obtaining a Dry Extract from theMikania laevigataLeaves with Potential for Antiulcer Activity.
abstract: BACKGROUND
  Mikania laevigataleaves are commonly used in Brazil as a medicinal plant.
  
  
  OBJECTIVE
  To obtain hydroalcoholic dried extract by nebulization and evaluate its antiulcerogenic potential.
  
  
  METHODS
  Plant material and hydroalcoholic extract were processed and analyzed for their physicochemical characteristics. A method using HPLC was validated to quantify coumarin and o-coumaric acid. Hydroalcoholic extract was spray dried and the powder obtained was characterized in terms of its physicochemical parameters and potential for antiulcerogenic activity.
  
  
  RESULTS
  The analytical method proved to be selective, linear, precise, accurate, sensitive, and robust.M. laevigataspray dried extract was obtained using colloidal silicon dioxide as adjuvant and was shown to possess 1.83 ± 0.004% coumarin and 0.80 ± 0.012% o-coumaric acid. It showed significant antiulcer activity in a model of an indomethacin-induced gastric lesion in mice and also produced a gastroprotective effect.
  
  
  CONCLUSIONS
  This dried extract fromM. laevigatacould be a promising intermediate phytopharmaceutical product.
  
  
  CONCLUSIONS
  Research and development of standardized dried extract ofMikania laevigataleaves obtained through spray drying and the production process was monitored by the chemical profile, physicochemical properties and potential for anti-ulcerogenic activity.Abbreviations used:DE:M. laevigataspray dried extract, HE: hydroalcoholic extract.
authors.affiliation: Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia-Goiás, Brazil.
authors.forename: Mariana Viana
authors.initials: MV
authors.lastname: Pinto
authors.affiliation: Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia-Goiás, Brazil.
authors.forename: Ezequiane Machado
authors.initials: EM
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de Goiás, Instituto de Ciências Biológicas-Laboratório de Farmacologia de Produtos Naturais-Goiânia, Goiás, Brazil.
authors.forename: Jose Luiz Rodrigues
authors.initials: JL
authors.lastname: Martins
authors.affiliation: Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia-Goiás, Brazil.
authors.forename: Jose Realino
authors.initials: JR
authors.lastname: de Paula
authors.affiliation: Universidade Federal de Goiás, Instituto de Ciências Biológicas-Laboratório de Farmacologia de Produtos Naturais-Goiânia, Goiás, Brazil.
authors.forename: Elson Alves
authors.initials: EA
authors.lastname: Costa
authors.affiliation: Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia-Goiás, Brazil.
authors.forename: Edemilson Cardoso
authors.initials: EC
authors.lastname: da Conceição
authors.affiliation: Universidade Federal de Goiás, Faculdade de Farmácia-Laboratório de Pesquisa em Produtos Naturais-Goiânia-Goiás, Brazil.
authors.forename: Maria Teresa Freitas
authors.initials: MT
authors.lastname: Bara
keywords: Antiulcerogenic activity; medicinal plant; quality control; spray drying