title: Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and BilateralRETWild-Type Neoplasm with Revision of the Literature.
abstract: Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation ofREToncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-typeRETgene. The histological and molecular features of this rare entity are presented and discussed with revision of the pertinent literature.
authors.affiliation: Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Gemelli Hospital, Rome Italy.
authors.forename: Gian Luca Rampioni
authors.initials: GL
authors.lastname: Vinciguerra
authors.affiliation: Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Gemelli Hospital, Rome Italy.
authors.forename: Niccolò
authors.initials: N
authors.lastname: Noccioli
authors.affiliation: Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Gemelli Hospital, Rome Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cippitelli
authors.affiliation: Laboratory of Clinical Molecular and Personalized Diagnostics, Institute of Biochemistry and Clinical Biochemistry, Catholic University and Foundation , Gemelli Hospital, Rome Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Minucci
authors.affiliation: Laboratory of Clinical Molecular and Personalized Diagnostics, Institute of Biochemistry and Clinical Biochemistry, Catholic University and Foundation , Gemelli Hospital, Rome Italy.
authors.forename: Ettore
authors.initials: E
authors.lastname: Capoluongo
authors.affiliation: Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Gemelli Hospital, Rome Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Bartolazzi
keywords: Medullary carcinoma; Oncocytic variant; RET; Thyroid