title: A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.
abstract: Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene(FGA)coded FPA might confer vulnerability to schizophrenia. 1,145 patients with schizophrenia and 1,016 healthy volunteers from the Han population in Northeast China were recruited. The association of three tag single nucleotide polymorphisms (SNPs) (rs2070011 in the 5'UTR, rs2070016 in intron 4, and rs2070022 in the 3'UTR) inFGAand schizophrenia was examined using a case-control study design. Genotypic distributions of these three SNPs were not found to be significantly different between cases and controls (rs2070011:χ2= 1.28,P= 0.528; rs2070016:χ2= 4.11,P= 0.128; rs2070022:χ2= 1.23,P= 0.541). There were also no significant differences in SNP allelic frequencies between cases and controls (allP> 0.05). Additionally, the frequency of haplotypes consisting of alleles of these three SNPs was not significantly different between cases and healthy control subjects (globalχ2= 9.27,P= 0.159). Our study did not show a significant association ofFGASNPs with schizophrenia. Future studies may need to test moreFGASNPs in a larger sample to identify those SNPs with a minor or moderate effect on schizophrenia.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Wenwang
authors.identifier: 0000-0002-3514-3082
authors.initials: W
authors.lastname: Rao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China; Department of Pharmacy, Stomatology Hospital, Jilin University, Changchun 130041, China.
authors.forename: Na
authors.identifier: 0000-0003-2656-7948
authors.initials: N
authors.lastname: Zhou
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Medical Center, VA Connecticut Healthcare System, West Haven, CT, USA.
authors.forename: Huiping
authors.identifier: 0000-0001-9662-1298
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Rui
authors.identifier: 0000-0002-1201-1140
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Shangchao
authors.identifier: 0000-0002-9110-7844
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Yingying
authors.identifier: 0000-0002-5788-0593
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Guang
authors.identifier: 0000-0002-4335-2618
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Yue
authors.identifier: 0000-0003-0805-1227
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Jieping
authors.identifier: 0000-0002-2134-9653
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Yaqin
authors.identifier: 0000-0002-8687-8839
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Qiong
authors.identifier: 0000-0003-1143-1749
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D005340:Fibrinogen