title: Improving the dissolution properties of curcumin using dense gas antisolvent technology.
abstract: The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone by the atomized rapid injection solvent extraction (ARISE) system. The compounds were co-precipitated from organic solutions using carbon dioxide at 30°C and 95bar as the antisolvent. Curcumin formulations were also produced by physical mixing and freeze drying for comparative purposes. The morphology, crystallinity, solid state molecular interactions, apparent solubility and dissolution profiles of samples were observed. The results indicate that the ARISE process is effective in the preparation of curcumin micro-composites with enhanced dissolution profiles compared to unprocessed material and products from physical mixing and freeze drying.
authors.affiliation: School of Chemical Engineering, University of New South Wales, Sydney 2052 NSW, Australia; Department of Chemical Engineering, Institute of Technology Sepuluh Nopember, Surabaya, Indonesia.
authors.forename: Firman
authors.initials: F
authors.lastname: Kurniawansyah
authors.affiliation: School of Chemical Engineering, University of New South Wales, Sydney 2052 NSW, Australia.
authors.forename: Lisa
authors.initials: L
authors.lastname: Quachie
authors.affiliation: School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Mammucari
authors.affiliation: School of Chemical and Petroleum Engineering, Curtin University, Perth 6845, WA, Australia. Electronic address: neil.foster@curtin.edu.au.
authors.forename: Neil R
authors.initials: NR
authors.lastname: Foster
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003474:Curcumin / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical; D014961:X-Ray Diffraction
chemical_list: D003474:Curcumin
keywords: CO(2); Curcumin; Dense gas; Dissolution; Micronization