title: Autoantibodies other than Anti-desmogleins in Pemphigus Vulgaris Patients.
abstract: BACKGROUND
  Pemphigus vulgaris (PV) is an immunoglobulin G-mediated autoimmune bullous skin disease. Nonorgan-specific antibodies were detected in Tunisian and Brazilian pemphigus patients with different prevalence.
  
  
  METHODS
  Fifty PV patients and fifty controls were screened for antinuclear antibodies (ANAs), anti-smooth muscle antibodies (ASMAs), anti-parietal antibodies (APAs), anti-mitochondrial antibodies, and Anti-nuclear cytoplasmic antibodies (ANCA) by indirect immunofluorescence.
  
  
  RESULTS
  Thirty-nine patients were female and 11 were male. Fifteen patients did not receive treatment before while 35 patients were on systemic steroid treatment ± azathioprine. Twenty (40%) of the PV patients and 1 (2%) control had positive ANA. ANA was significantly higher in PV patients than controls,P< 0.0001. ASMAs were detected in 20 (40%) PV patients and none of the controls. ASMA was significantly higher in PV patients than controls,P< 0.0001. No significant difference was detected between treated and untreated regarding ANA,P- 0.11. However, there was a significant difference between treated and untreated regarding ASMA,P- 0.03. Six patients (12%) and none of the controls had positive APA. There was a significant difference between the patients and the controls in APA.P- 0.027.
  
  
  CONCLUSIONS
  Egyptian PV patients showed more prevalent ANA, ASMA, and APA than normal controls. Follow-up of those patients is essential to detect the early development of concomitant autoimmune disease. Environmental factors might account for the variability of the nonorgan-specific antibodies among different populations.
authors.affiliation: Department of Dermatology, Cairo University, Cairo, Egypt.
authors.forename: Marwah Adly
authors.initials: MA
authors.lastname: Saleh
authors.affiliation: Department of Medical Biochemistry, Cairo University, Cairo, Egypt; Department of Medical Biology, Faculty of Medicine, Jazan University, Jizan, Saudi Arabia.
authors.forename: Hedayat
authors.initials: H
authors.lastname: Salem
authors.affiliation: Department of Medical Biochemistry, Cairo University, Cairo, Egypt.
authors.forename: Hoda
authors.initials: H
authors.lastname: El Azizy
keywords: Anti-mitochondrial antibodies; anti-parietal antibodies; anti-smooth muscle antibodies; antinuclear antibodies; antinuclear cytoplasmic antibodies; autoantibodies; autoimmune bullous diseases; pemphigus vulgaris