title: The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus.
abstract: In the last two decades adiponectin, member of the adipokines family, gained attention because of its unique antidiabetic effects. However, the presence in the brain of adiponectin receptors and adiponectin itself raised interest because of the possible association with neuropsychiatric diseases. Indeed, clinical studies found altered concentration of adiponectin both in plasma and cerebrospinal fluid in several pathologies including depression, multiple sclerosis, Alzheimer's disease and stroke. Moreover, recent preclinical studies also suggest its involvement in different physiological functions. Despite this evidence very few studies attempted to elucidate the functional role of adiponectin at the synapse. To address this question, here we investigated the effect of Adiporon, an agonist of both adiponectin receptors on synaptic transmission and LTP at Schaffer-collateral CA1 pathway. Surprisingly, increasing concentration of Adiporon correlated with lower CA1-LTP levels and paired-pulse ratio, whereas basal transmission was always preserved. Collectively, our data show that the adiponectin system, beyond its involvement in metabolic diseases, plays also a critical role in synaptic activity thereby representing a putative target for the treatment of synaptic pathologies.
authors.affiliation: Department of Pharmacology of Synaptic Plasticity Lab, Fondazione EBRI-Rita Levi Montalcini, Rome, Italy.|Department of Physiology and Pharmacology Erspamer, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Filippo
authors.identifier: 0000-0001-7420-7280
authors.initials: F
authors.lastname: Weisz
authors.affiliation: Department of Pharmacology of Synaptic Plasticity Lab, Fondazione EBRI-Rita Levi Montalcini, Rome, Italy.|Department of Physiology and Pharmacology Erspamer, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Piccinin
authors.affiliation: Department of Pharmacology of Synaptic Plasticity Lab, Fondazione EBRI-Rita Levi Montalcini, Rome, Italy.|Department of Physiology and Pharmacology Erspamer, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Dalila
authors.initials: D
authors.lastname: Mango
authors.affiliation: School of Pharmacy, University of Lincoln, Lincoln, United Kingdom.
authors.forename: Richard Teke
authors.initials: RT
authors.lastname: Ngomba
authors.affiliation: University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Nicola B
authors.initials: NB
authors.lastname: Mercuri
authors.affiliation: Department of Physiology and Pharmacology Erspamer, University of Rome "La Sapienza", Rome, Italy.|IRCCS Neuromed, Pozzilli, Italy.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.affiliation: Department of Pharmacology of Synaptic Plasticity Lab, Fondazione EBRI-Rita Levi Montalcini, Rome, Italy.|University of Rome "Tor Vergata", Rome, Italy.
authors.forename: Robert
authors.identifier: 0000-0003-3433-9232
authors.initials: R
authors.lastname: Nisticò
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D017774:Long-Term Potentiation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010880:Piperidines / Q000494:pharmacology; D054419:Receptors, Adiponectin / Q000819:agonists / Q000378:metabolism*; D009435:Synaptic Transmission
chemical_list: C585113:AdipoRon; D010880:Piperidines; D054419:Receptors, Adiponectin
keywords: Adiporon; adiponectin; electrophysiology; hippocampus; long term potentiation; synaptic plasticity