title: Occurrence of Crohn's disease with Parkinson's disease.
abstract: We retrospectively investigated the co-occurrence of Crohn's disease in a cohort of 876 patients with Parkinson's disease, based on the observation that LRRK2 is a shared genetic risk factor. We identified 2 patients with Crohn's disease; this number was consistent with the number of cases expected in the general population.
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States; Department of Neurology, Fukuoka University, Fukuoka 8140180, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Fujioka
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn Medical Center, Sigmund-Freund-Str. 25, 53127 Bonn, Germany.
authors.forename: Sadie E
authors.initials: SE
authors.lastname: Curry
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn Medical Center, Sigmund-Freund-Str. 25, 53127 Bonn, Germany.
authors.forename: Kathleen D
authors.initials: KD
authors.lastname: Kennelly
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn Medical Center, Sigmund-Freund-Str. 25, 53127 Bonn, Germany.
authors.forename: Pawel
authors.initials: P
authors.lastname: Tacik
authors.affiliation: Biostatistics Unit, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Heckman
authors.affiliation: Department of Neurology, Fukuoka University, Fukuoka 8140180, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsuboi
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Audrey J
authors.initials: AJ
authors.lastname: Strongosky
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Jay A
authors.initials: JA
authors.lastname: van Gerpen
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.affiliation: Departments of Pharmacology and Experimental Therapeutics and Neurology, Boston University School of Medicine, Boston, MA, United States.
authors.forename: Tsuneya
authors.initials: T
authors.lastname: Ikezu
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL, United States. Electronic address: wszolek.zbigniew@mayo.edu.
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003424:Crohn Disease / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics; D012189:Retrospective Studies
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
keywords: Co-occurrence; Crohn's disease; LRRK2; Parkinson’s disease