title: A Mathematical Model of Neutral Lipid Content in terms of Initial Nitrogen Concentration and Validation inCoelastrumsp. HA-1 and Application inChlorella sorokiniana.
abstract: Microalgae are considered to be a potential major biomass feedstock for biofuel due to their high lipid content. However, no correlation equations as a function of initial nitrogen concentration for lipid accumulation have been developed for simplicity to predict lipid production and optimize the lipid production process. In this study, a lipid accumulation model was developed with simple parameters based on the assumption protein synthesis shift to lipid synthesis by a linear function of nitrogen quota. The model predictions fitted well for the growth, lipid content, and nitrogen consumption ofCoelastrumsp. HA-1 under various initial nitrogen concentrations. Then the model was applied successfully inChlorella sorokinianato predict the lipid content with different light intensities. The quantitative relationship between initial nitrogen concentrations and the final lipid content with sensitivity analysis of the model were also discussed. Based on the model results, the conversion efficiency from protein synthesis to lipid synthesis is higher and higher in microalgae metabolism process as nitrogen decreases; however, the carbohydrate composition content remains basically unchanged neither in HA-1 nor inC. sorokiniana.
authors.affiliation: Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Zhenhua
authors.identifier: 0000-0002-1952-3931
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Chenfeng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Yuyong
authors.identifier: 0000-0002-4302-4147
authors.initials: Y
authors.lastname: Hou
mesh_terms: D002708:Chlorella / Q000378:metabolism*; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids / Q000096:biosynthesis*; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism*
chemical_list: D008055:Lipids; D009584:Nitrogen