title: [Progress in research on pathogenic genes and gene therapy for inherited retinal diseases].
abstract: Inherited retinal diseases (IRDs), including retinitis pigmentosa, Usher syndrome, Cone-Rod degenerations, inherited macular dystrophy, Leber's congenital amaurosis, Leber's hereditary optic neuropathy are the most common and severe types of hereditary ocular diseases. So far more than 200 pathogenic genes have been identified. With the growing knowledge of the genetics and mechanisms of IRDs, a number of gene therapeutic strategies have been developed in the laboratory or even entered clinical trials. Here the progress of IRD research on the pathogenic genes and therapeutic strategies, particularly gene therapy, are reviewed.
authors.affiliation: Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. ppjiang@zju.edu.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Cong
authors.initials: C
authors.lastname: Cao
authors.forename: Jiji
authors.initials: J
authors.lastname: Sun
authors.forename: Tao
authors.initials: T
authors.lastname: Gao
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Liang
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Nie
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Ji
authors.forename: Pingping
authors.initials: P
authors.lastname: Jiang
authors.forename: Minxin
authors.initials: M
authors.lastname: Guan
mesh_terms: D035843:Biomedical Research / Q000379:methods / Q000639:trends; D002986:Clinical Trials as Topic; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D009154:Mutation; D012164:Retinal Diseases / Q000235:genetics* / Q000628:therapy*; D016896:Treatment Outcome