title: Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis.
abstract: Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA. Valuable work on exploring TCM merits for OA patients has been investigated using modern technologies, although the complicated interacting network among the numerous components indicates the uncertainty of target specification. This review will provide an overview of the action mechanism of TCM in the last 5 years, discussing the TCM activities of anti-inflammation, antiapoptosis, antioxidation, anticatabolism, and proliferation in OA. TCM is a proposed medical option for OA treatment.
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Linfu
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Weimei
authors.initials: W
authors.lastname: Shi
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Clinical Research Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
authors.forename: Jianqiong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Pharmacology, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Daohua
authors.initials: D
authors.lastname: Xu
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Hao
authors.identifier: 0000-0002-7788-5519
authors.initials: H
authors.lastname: Huang
authors.affiliation: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors.forename: Longhuo
authors.identifier: 0000-0002-3899-9599
authors.initials: L
authors.lastname: Wu