title: Heart failure guidelines: What's new?
abstract: Heart Failure is a global epidemic, affecting approximately 5 million adults in the U.S.A. The cornerstone of contemporary pharmacological therapy targets the over activated renin-angiotensin-aldosterone and sympathetic autonomic systems. The 2016 focused pharmacologic update on the current Heart Failure Guidelines introduces the use of two newly approved regimens valsartan/sacubitril and ivabradine. Over the last two decades, guideline directed medical therapy has accomplished significant improvement in survival rates among heart failure patients; however these novel compounds were reported to exert additional mortality and morbidity benefits, in heart failure subpopulations with reduced ejection fraction.
authors.affiliation: From the Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA. Electronic address: lampros.papadimitriou@stonybrookmedicine.edu.
authors.forename: Lampros
authors.initials: L
authors.lastname: Papadimitriou
authors.affiliation: From the Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Carine E
authors.initials: CE
authors.lastname: Hamo
authors.affiliation: From the Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Javed
authors.initials: J
authors.lastname: Butler
mesh_terms: D000613:Aminobutyrates / Q000627:therapeutic use; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D001552:Benzazepines / Q000627:therapeutic use; D001713:Biphenyl Compounds; D002309:Cardiology / Q000592:standards*; D002317:Cardiovascular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D019983:Guideline Adherence / Q000592:standards; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D000077550:Ivabradine; D017410:Practice Guidelines as Topic / Q000592:standards*; D010818:Practice Patterns, Physicians' / Q000592:standards; D013777:Tetrazoles / Q000627:therapeutic use; D016896:Treatment Outcome; D000068756:Valsartan
chemical_list: D000613:Aminobutyrates; D057911:Angiotensin Receptor Antagonists; D001552:Benzazepines; D001713:Biphenyl Compounds; D002317:Cardiovascular Agents; D004338:Drug Combinations; D013777:Tetrazoles; D000077550:Ivabradine; D000068756:Valsartan; C549068:sacubitril and valsartan sodium hydrate drug combination
keywords: Guidelines; Heart failure; Ivabradine; Valsartan/sacubitril