title: Patch testing for adverse drug reactions.
abstract: Adverse drug reactions result in a substantial number of hospital admissions and inpatient events. Diagnosis usually is made with clinical judgment and circumstantiality without diagnostic testing. Furthermore, even in situations where diagnostic testing is performed, no safe gold standard tests exist. Oral rechallenge is currently the gold standard but carries the risk of recrudescence of severe allergic symptoms. Other tests include skin prick tests, the lymphocyte transformation test, immunohistochemistry, and patch testing. This article provides a review of patch testing in cases of adverse drug reactions and presents new data on this topic.
authors.affiliation: Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Ohio, USA.
authors.forename: Sahil
authors.initials: S
authors.lastname: Sekhon
authors.affiliation: Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Ohio, USA.
authors.forename: Susan T
authors.initials: ST
authors.lastname: Nedorost
mesh_terms: D004342:Drug Hypersensitivity / Q000175:diagnosis*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008213:Lymphocyte Activation; D010328:Patch Tests / Q000379:methods*; D012882:Skin Tests / Q000379:methods