title: Manipulating the gut microbiome to decrease uremic toxins.
abstract: The uremic solute indoxyl sulfate has been associated with increased mortality and other adverse outcomes in patients with chronic kidney disease. In a recent study published in Cell Host & Microbe, Devlin et al. describe a novel approach to alter the production of indoxyl sulfate through manipulation of the gut microbiota. Although this approach is far from clinical application, it may allow investigators to determine the contribution of uremic solutes to disease pathogenesis.
authors.affiliation: Department of Medicine, Division of Nephrology, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, New York, USA.
authors.forename: Rabi
authors.initials: R
authors.lastname: Yacoub
authors.affiliation: Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: christina.wyatt@mssm.edu.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Wyatt
mesh_terms: D000818:Animals; D001439:Bacteroides / Q000235:genetics / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D007200:Indican / Q000378:metabolism* / Q000633:toxicity; D009154:Mutation; D010641:Phenotype; D014511:Uremia / Q000378:metabolism* / Q000382:microbiology / Q000401:mortality
chemical_list: D007200:Indican