title: Thermo-responsive nanoarrays of silver nanoparticle, silicate nanoplatelet and PNiPAAm for the antimicrobial applications.
abstract: The ternary nanohybrids of silver nanoparticles (AgNPs) in combination with silicate nanoplatelets (NSP) and thermally sensitive poly(N-isopropylacrylamide) (PNiPAAm) were fabricated for antibacterial applications. PNiPAAm were chemically grafted on the NSP by atom-transfer radical polymerization (ATRP) via polymerizing N-isopropylacrylamide monomers with sol-gel linkers (BBTES). The nanoparticles of AgNPs then were adsorbed on NSP-PNiPAAm nanosheets through in situ reduction reaction of AgNO3in aqueous dispersion. The particle sizes of AgNPs were estimated to be 7-12nm in diameter with different composition ratios of AgNPs to NSP-PNiPAAm, evaluated by transmission electron microscope (TEM). The nanohybrids of AgNP/NSP-PNiPAAm exhibited the unique property of lowest critical solution temperature (LCST) at 32°C. The thermo-responsive antibacterial efficacy of the ternary nanohybrids was demonstrated by Bacillus subtilis (B. subtilis) and Escherichia coli (E. coli) at lower than the LCST (28°C) and higher than the LCST (37°C). The result show that the great antibacterial ability was observed in the hydrophilic bacteria (B. subtilis) at 28°C. In contrast, the excellent antibacterial ability was found in the hydrophobic bacteria (E. coli) at 37°C, due to the surface energy modulation of AgNP/NSP-PNiPAAm. The tailoring of silver-containing ternary nanohybrids allow the new antibacterial nanomaterials to selectively affect the surface of bacteria by varying temperature.
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Hsiao-Chu
authors.initials: HC
authors.lastname: Lin
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Yu-An
authors.initials: YA
authors.lastname: Su
authors.affiliation: Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan. Electronic address: tyliu0322@gmail.com.
authors.forename: Ting-Yu
authors.initials: TY
authors.lastname: Liu
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. Electronic address: yjsheng@ntu.edu.tw.
authors.forename: Yu-Jane
authors.initials: YJ
authors.lastname: Sheng
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan. Electronic address: jianglin@ntu.edu.tw.
authors.forename: Jiang-Jen
authors.initials: JJ
authors.lastname: Lin
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D058105:Polymerization; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; C052970:poly-N-isopropylacrylamide; D012834:Silver
keywords: Antimicrobial activity; Poly(N-isopropylacrylamide); Silicate platelet; Silver nanoparticle; Thermo-sensitive stimulus