title: Mechanism of capsaicin inhibition of aldose reductase activity.
abstract: Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. Kivalues of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway.
authors.affiliation: Department of Chemistry, Faculty of Science and Arts, Ahi Evran University, 40000, Kırşehir, Turkey.
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Alim
authors.affiliation: Department of Medical Services and Techniques, Vocational School of Health Service, Iğdır University, 76000, Iğdır, Turkey.
authors.forename: Namık
authors.initials: N
authors.lastname: Kilinc
authors.affiliation: Department of Health Care Service, Vocational School of Health Service, Bayburt University, 69000, Bayburt, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Sengul
authors.affiliation: Department of Chemistry, Faculty of Sciences, Atatürk University, 25240, Erzurum, Turkey.|Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
authors.forename: Sukru
authors.initials: S
authors.lastname: Beydemir
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004791:Enzyme Inhibitors; D000449:Aldehyde Reductase; D002211:Capsaicin
keywords: aldose reductase; capsaicin; diabetic complications; inhibition