title: Shape-controlled fabrication of magnetite silver hybrid nanoparticles with high performance magnetic hyperthermia.
abstract: Superparamagnetic Fe3O4nanoparticles (NPs)-based hyperthermia is a promising non-invasive approach for cancer therapy. However, the heat transfer efficiency of Fe3O4NPs is relative low, which hinders their practical clinical applications. Therefore, it is promising to improve the magnetic hyperthermia efficiency by exploring the higher performance magnetic NPs-based hybrid nanostructures. In the current study, it presents a straightforward in situ reduction method for the shape-controlled preparation of magnetite (Fe3O4) silver (Ag) hybrid NPs designed as magnetic hyperthermia heat mediators. The magnetite silver hybrid NPs with core-shell (Fe3O4@Ag) or heteromer (Fe3O4-Ag) structures exhibited a higher biocompatibility with SMMC-7721 cells and L02 cells than the individual Ag NPs. Importantly, in the magnetic hyperthermia, with the exposure to alternating current magnetic field, the Fe3O4@Ag and Fe3O4-Ag hybrid NPs indicated much better tumor suppression effect against SMMC-7721 cells than the individual Fe3O4NPs in vitro and in vivo. These results demonstrate that the hybridisation of Fe3O4and Ag NPs could greatly enhance the magnetic hyperthermia efficiency of Fe3O4NPs. Therefore, the Fe3O4@Ag and Fe3O4-Ag hybrid NPs can be used to be as high performance magnetic hyperthermia mediators based on a simple and effective preparation approach.
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ding
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Medical School, Zhongda Hospital, Southeast University, Nanjing 210009, PR China.
authors.forename: Dongfang
authors.initials: D
authors.lastname: Liu
authors.affiliation: Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China.
authors.forename: Xingyun
authors.initials: X
authors.lastname: Pang
authors.affiliation: Laboratory of Advanced Materials, Department of Materials Science, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200438, PR China.
authors.forename: Renchao
authors.initials: R
authors.lastname: Che
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China.
authors.forename: Naizhen
authors.initials: N
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou, 215123, PR China. Electronic address: guning@seu.edu.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003460:Crystallization / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D055909:Magnetic Field Therapy / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure*; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D010316:Particle Size; D012834:Silver / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D058185:Magnetite Nanoparticles; D058726:Nanoconjugates; D012834:Silver
keywords: Hyperthermia; Magnetic nanoparticles; Nanocomposites; Shape control; Silver