title: Changes in Serum Adiponectin in Mice Chronically Exposed to Inorganic Arsenic in Drinking Water.
abstract: Cardiovascular disease and diabetes mellitus are prominent features of glucose and lipid metabolism disorders. Adiponectin is a key adipokine that is largely involved in glucose and lipid metabolism processes. A growing body of evidence suggests that chronic exposure to inorganic arsenic is associated with cardiovascular disease and diabetes mellitus. We hypothesized that arsenic exposure may increase the risk of cardiovascular disease and diabetes mellitus by affecting the level of adiponectin. In this study, we examined serum adiponectin levels, as well as serum levels of metabolic measures (including fasting blood glucose, insulin, total cholesterol, triglyceride, and high-density lipoprotein (HDL)-cholesterol) in C57BL/6 mice exposed to inorganic arsenic in drinking water (5 and 50 ppm NaAsO2) for 18 weeks. Body mass and adiposity were monitored throughout the study. We found no significant changes in serum insulin and glucose levels in mice treated with arsenic for 18 weeks. However, arsenic exposure decreased serum levels of adiponectin, triglyceride, and HDL-cholesterol. Further, an inverse relationship was observed between urinary concentrations of total arsenic and serum levels of adiponectin. This study suggests that arsenic exposure could disturb the metabolism of lipids and increase the risk of cardiovascular disease by reducing the level of adiponectin.
authors.affiliation: Key Laboratory of Etiologic Epidemiology of National Health and Family Planning Commission, Key Laboratory of Etiologic Epidemiology of Education Bureau of Heilongjiang Province, The Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, China.
authors.forename: Xuanbo
authors.initials: X
authors.lastname: Song
authors.affiliation: Key Laboratory of Etiologic Epidemiology of National Health and Family Planning Commission, Key Laboratory of Etiologic Epidemiology of Education Bureau of Heilongjiang Province, The Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Etiologic Epidemiology of National Health and Family Planning Commission, Key Laboratory of Etiologic Epidemiology of Education Bureau of Heilongjiang Province, The Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, China.
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Laboratory of Etiologic Epidemiology of National Health and Family Planning Commission, Key Laboratory of Etiologic Epidemiology of Education Bureau of Heilongjiang Province, The Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ji
authors.affiliation: Key Laboratory of Etiologic Epidemiology of National Health and Family Planning Commission, Key Laboratory of Etiologic Epidemiology of Education Bureau of Heilongjiang Province, The Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, China. zhaolijun@hrbmu.edu.cn.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Community Medicine, Mercer University School of Medicine, Macon, GA, 31027, USA. wei_yd@mercer.edu.
authors.forename: Yudan
authors.initials: Y
authors.lastname: Wei
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D018053:Arsenites / Q000008:administration & dosage* / Q000633:toxicity* / Q000652:urine; D002318:Cardiovascular Diseases / Q000097:blood / Q000139:chemically induced; D060766:Drinking Water / Q000008:administration & dosage* / Q000737:chemistry*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017670:Sodium Compounds / Q000008:administration & dosage* / Q000633:toxicity* / Q000652:urine
chemical_list: D052242:Adiponectin; D018053:Arsenites; D060766:Drinking Water; D008055:Lipids; D017670:Sodium Compounds; C017947:sodium arsenite
keywords: Adiponectin,; Arsenic,; Lipid metabolism,; Mice