title: DYNAMISM OF DOT SUBRETINAL DRUSENOID DEPOSITS IN AGE-RELATED MACULAR DEGENERATION DEMONSTRATED WITH ADAPTIVE OPTICS IMAGING.
abstract: OBJECTIVE
  To investigate the natural history of dot subretinal drusenoid deposits (SDD) in age-related macular degeneration, using high-resolution adaptive optics scanning laser ophthalmoscopy.
  
  
  METHODS
  Six eyes of four patients with intermediate age-related macular degeneration were studied at baseline and 1 year later. Individual dot SDD within the central 30° retina were examined with adaptive optics scanning laser ophthalmoscopy and optical coherence tomography.
  
  
  RESULTS
  A total of 269 solitary SDD were identified at baseline. Over 12.25 ± 1.18 months, all 35 Stage 1 SDD progressed to advanced stages. Eighteen (60%) Stage 2 lesions progressed to Stage 3 and 12 (40%) remained at Stage 2. Of 204 Stage 3 SDD, 12 (6.4%) disappeared and the rest remained. Twelve new SDD were identified, including 6 (50%) at Stage 1, 2 (16.7%) at Stage 2, and 4 (33.3%) at Stage 3. The mean percentage of the retina affected by dot SDD, measured by the adaptive optics scanning laser ophthalmoscopy, increased in 5/6 eyes (from 2.31% to 5.08% in the most changed eye) and decreased slightly in 1/6 eye (from 10.67% to 10.54%). Dynamism, the absolute value of the areas affected by new and regressed lesions, ranged from 0.7% to 9.3%.
  
  
  CONCLUSIONS
  Adaptive optics scanning laser ophthalmoscopy reveals that dot SDD, like drusen, are dynamic.
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Pooja
authors.initials: P
authors.lastname: Godara
authors.affiliation: Department of Bioengineering, University of California, Berkeley, California.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Clark
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: C Douglas
authors.initials: CD
authors.lastname: Witherspoon
authors.affiliation: Vitreous-Retina-Macula Consultants of New York, New York, New York.
authors.forename: Richard F
authors.initials: RF
authors.lastname: Spaide
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Owsley
authors.affiliation: Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Curcio
mesh_terms: D004867:Equipment Design; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D055095:Optics and Photonics; D015203:Reproducibility of Results; D015593:Retinal Drusen / Q000175:diagnosis* / Q000209:etiology; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D057135:Wet Macular Degeneration / Q000150:complications* / Q000175:diagnosis