title: Colorectal cancer-global burden, trends, and geographical variations.
abstract: BACKGROUND
  The aim of this study is to describe the trends and variations in the global burden of colorectal cancer (CRC).
  
  
  METHODS
  Data (2012-2030) relating to CRC was extracted from GLOBOCAN 2012 database and analyzed.
  
  
  RESULTS
  The results of our study demonstrate a rising global burden of colorectal cancer which persists until the year 2035 and likely beyond. The rise in the global burden is not uniform with significant variations influenced by geographic location, socio-economic status, age, and gender. Although the EURO region has the highest burden, Asia as a continent continues to bear the heaviest brunt of the disease. Although the burden of disease is higher in more developed regions, mortality is considerably higher in less developed regions and this gap widens over the next two decades. The disease predominantly affects the male gender across all regions of the world. Age has a complex relation with the burden of CRC and is affected by the cross-influences relating to socio-economic status.
  
  
  CONCLUSIONS
  The results of our study demonstrate a rising global burden of CRC with some unique variations. Knowledge of this data can increase awareness and help strategic targeting of efforts and resources.
authors.affiliation: Department of Surgery, UniversityOf Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Douaiher
authors.affiliation: Johns Hopkins University, Baltimore, Maryland.
authors.forename: Advaitaa
authors.initials: A
authors.lastname: Ravipati
authors.affiliation: Department of Surgery, UniversityOf Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Grams
authors.affiliation: Boston University Medical Center, Boston, Massachusetts.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Chowdhury
authors.affiliation: Obafemi Awolowo University, Ile-Ife, Osun, Nigeria.
authors.forename: Olusegun
authors.initials: O
authors.lastname: Alatise
authors.affiliation: Department of Surgery, UniversityOf Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Chandrakanth
authors.initials: C
authors.lastname: Are
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D016208:Databases, Factual; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D008297:Male; D017678:Sex Distribution
keywords: colorectal cancer; epidemiology; global heath; incidence; mortality