title: Quality of life of patients with graft-versus-host disease (GvHD) post-hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  Assessing the quality of life of adult patients with hematological cancer in the 100 days after transplantation of hematopoietic stem cells and verifying whether the variable graft-versus-host disease (GvHD) is predictive of worse results.
  
  
  METHODS
  An observational correlational and quantitative study with 36 adult participants diagnosed with hematologic cancer who underwent hematopoietic stem cell transplantation from September 2013 to June 2015.
  
  
  RESULTS
  The mean age was 37 years, 52.78% were female, and 61.11% were diagnosed with leukemia. Quality of life scores showed a significant impact between pre-transplantation and pre-hospital discharge, and also within the 100 days post-transplantation. The statistical analysis between the scores for the groups with and without GvHD showed a significant difference between the presence of the complication and worse results.
  
  
  CONCLUSIONS
  Quality of life is altered as a result of hematopoietic stem cells transplantation, especially in patients who have graft-versus-host disease.
  
  
  OBJECTIVE
  Avaliar a qualidade de vida de pacientes adultos com câncer hematológico nos 100 dias do transplante de células-tronco hematopoéticas e verificar se a variável doença do enxerto contra o hospedeiro é preditiva de piores resultados.
  Estudo observacional, correlacional e quantitativo, com 36 participantes adultos, diagnosticados com câncer hematológico que se submeteram ao transplante de células-tronco hematopoéticas de setembro de 2013 a junho de 2015.
  
  
  RESULTS
  A média de idade foi 37 anos, 52,78% eram do sexo feminino, e 61,11% com diagnóstico de leucemia. Os escores de qualidade de vida demonstraram impacto significativo entre o pré-transplante e a pré-alta hospitalar e entre os 100 dias pós-transplante. A análise estatística entre os escores dos grupos com e sem doença do enxerto contra o hospedeiro evidenciou significância entre a presença desta complicação e piores resultados.
  A qualidade de vida é alterada em decorrência do transplante de células-tronco hematopoéticas, em especial nos pacientes que apresentam doença do enxerto contra o hospedeiro.
authors.affiliation: Universidade Federal do Paraná, Complexo Hospital de Clínicas, Curitiba, PR, Brazil.
authors.forename: Sibéli de Fátima Ferraz Simão
authors.initials: SF
authors.lastname: Proença
authors.affiliation: Universidade Federal do Paraná, Complexo Hospital de Clínicas, Curitiba, PR, Brazil.
authors.forename: Celina Mattos
authors.initials: CM
authors.lastname: Machado
authors.affiliation: Universidade Federal do Paraná, Complexo Hospital de Clínicas, Curitiba, PR, Brazil.
authors.forename: Raquel de Castro Figueiredo Pereira
authors.initials: RC
authors.lastname: Coelho
authors.affiliation: Universidade Federal do Paraná, Departamento de Enfermagem, Curitiba, PR, Brazil.
authors.forename: Leila Maria Mansano
authors.initials: LM
authors.lastname: Sarquis
authors.affiliation: Universidade Federal do Paraná, Departamento de Estatística, Curitiba, PR, Brazil.
authors.forename: Paulo Ricardo Bittencourt
authors.initials: PR
authors.lastname: Guimarães
authors.affiliation: Universidade Federal do Paraná, Departamento de Enfermagem, Curitiba, PR, Brazil.
authors.forename: Luciana Puchalski
authors.initials: LP
authors.lastname: Kalinke
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D011788:Quality of Life; D055815:Young Adult