title: Conditions associated with REM sleep behaviour disorder: Description of a hospital series.
abstract: BACKGROUND
  REM sleep behaviour disorder (RBD) is characterised by violent behaviours (screaming, kicking, vivid dreams) during REM sleep. It has a prevalence of 1% to 2% of the general population and is especially frequent in men and the population older than 60. In the last decade, RBD has been suggested to be a prodrome of neurodegenerative disease. We analysed associated neurological diseases and responses to drug treatment in 33 patients with RBD treated in the multidisciplinary sleep disorders unit at Hospital Infanta Sofía.
  
  
  METHODS
  We conducted an observational descriptive retrospective analysis of patients diagnosed with RBD and treated in our multidisciplinary sleep disorders unit between October 2012 and December 2015. We recorded age, sex, associated diseases, and treatments administered to these patients.
  
  
  RESULTS
  A total of 365 patients were attended at our unit, including 33 with RBD: 13 women (40%) and 20 men (60%). Mean age was 62.72 years. An associated disorder was identified in 48%, with the most common being mild cognitive impairment (69%). The percentage of patients with RBD and an associated disorder among patients older than 60 was 68%. Eighty-two percent of the patients required treatment. The most commonly used drug was clonazepam (76%), followed by melatonin (9%), gabapentin (6%), and trazodone (3%).
  
  
  CONCLUSIONS
  In our series, 48% of the patients had an associated disorder. The likelihood of detecting an associated disorder increases with patients' age. The vast majority of patients required drug treatment due to symptom severity; the most frequently administered drug was clonazepam (76%).
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España. Electronic address: mjose.abenza@salud.madrid.org.
authors.forename: M J
authors.initials: MJ
authors.lastname: Abenza Abildúa
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Miralles Martinez
authors.affiliation: Servicio de Neurología, Hospital Universitario Clínico San Carlos, Madrid, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: Arpa Gutiérrez
authors.affiliation: Sección de Neumología, Centro de Medicina del Sueño, San Sebastián de los Reyes, Madrid, España.
authors.forename: V
authors.initials: V
authors.lastname: Lores Gutiérrez
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Algarra Lucas
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Jimeno Montero
authors.affiliation: Sección de Neumología, Centro de Medicina del Sueño, San Sebastián de los Reyes, Madrid, España.
authors.forename: B
authors.initials: B
authors.lastname: Sánchez García
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Mata Álvarez-Santullano
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Borrue Fernández
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: G
authors.initials: G
authors.lastname: Cordero Martín
authors.affiliation: Sección de Neumología, Centro de Medicina del Sueño, San Sebastián de los Reyes, Madrid, España.
authors.forename: G
authors.initials: G
authors.lastname: Gutiérrez Cueto
authors.affiliation: Sección de Neurología, Centro de Medicina del Sueño, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: M D
authors.initials: MD
authors.lastname: Torrecillas Narváez
authors.affiliation: Servicio de Estadística, Universidad Europea de Madrid, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Thuissard Vasallo
authors.affiliation: Sección de Neumología, Centro de Medicina del Sueño, San Sebastián de los Reyes, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Gómez Aceña
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases; D017286:Polysomnography / Q000379:methods; D062706:Prodromal Symptoms; D020187:REM Sleep Behavior Disorder / Q000188:drug therapy*; D012189:Retrospective Studies; D013030:Spain
chemical_list: D000927:Anticonvulsants; D002998:Clonazepam
keywords: Demencia; Enfermedad de Parkinson; Multidisciplinary sleep disorders unit; Parkinson's disease; Prodrome; Pródromo; REM sleep behaviour disorder; Sleep disorders; Trastorno de conducta del sueño REM; Trastornos del sueño; Unidad Multidisciplinar de trastornos del sueño