title: Matrix Metalloproteinases as Regulators of Periodontal Inflammation.
abstract: Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the 'protease web' is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules-such as cytokines, chemokines, and growth factors, among others-regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation.
authors.affiliation: Department of Conservative Dentistry, School of Dentistry, Universidad de Chile, Santiago 8380492, Chile. francocavalla@gmail.com.|Department of Biological Sciences, School of Dentistry of Bauru, University of São Paulo (FOB/USP), Bauru, São Paulo 17012-901, Brazil. francocavalla@gmail.com.|Center for Craniofacial Research, University of Texas School of Dentistry at Houston, Houston, TX 77054, USA. francocavalla@gmail.com.
authors.forename: Cavalla
authors.initials: C
authors.lastname: Franco
authors.affiliation: Department of Conservative Dentistry, School of Dentistry, Universidad de Chile, Santiago 8380492, Chile. phernandezrios@gmail.com.
authors.forename: Hernández-Ríos
authors.initials: HR
authors.lastname: Patricia
authors.affiliation: Department of Oral and Maxillofacial Diseases, Helsinki University and Helsinki University Central Hospital, Helsinki 00290, Finland. timo.sorsa@helsinki.fi.|Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge 14183, Sweden. timo.sorsa@helsinki.fi.
authors.forename: Sorsa
authors.initials: S
authors.lastname: Timo
authors.affiliation: Department of Biological Sciences, School of Dentistry of Bauru, University of São Paulo (FOB/USP), Bauru, São Paulo 17012-901, Brazil. biguetti@usp.br.|Center for Craniofacial Research, University of Texas School of Dentistry at Houston, Houston, TX 77054, USA. biguetti@usp.br.
authors.forename: Biguetti
authors.initials: B
authors.lastname: Claudia
authors.affiliation: Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile. mhernandezrios@gmail.com.|Dentistry Unit, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago 8910060, Chile. mhernandezrios@gmail.com.
authors.forename: Hernández
authors.initials: H
authors.lastname: Marcela
mesh_terms: D004789:Enzyme Activation; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008954:Models, Biological; D010510:Periodontal Diseases / Q000201:enzymology*; D015398:Signal Transduction
chemical_list: D020782:Matrix Metalloproteinases
keywords: MMPs; chronic periodontitis; modulation; periodontal inflammation regulation