title: Design and Synthesis of Nanofibers of Self-assembledde novoGlycoconjugates towards Mucosal Lining Restoration and Anti-Inflammatory Drug Delivery.
abstract: The medical practice for IBD is solely based on anti-inflammatory drugs, but the outcome is far from ideal. Our long-term research goal is to seek a better clinical outcome by combining the anti-inflammatory therapy with physical mucus layer restoration. As the first step towards that objective, we choose to develop self-assembled hydrogels ofde novoglycoconjugates that consist of anti-inflammatory drugs and glycopeptides. By covalently linking peptides (e.g., nap-phe-phe-lys), saccharides (e.g., glucosamine), and an anti-inflammatory drug (i.e., olsalazine), we have demonstrated that the obtained molecules self-assemble in water to form hydrogels composed of 3D networks of the nanofibers under acidic conditions. We also confirmed that the resulting glycoconjugates are cell compatible. However, the preliminary assessment of the efficacy of the hydrogels on the murine model is inconclusive, which warrants further investigation and molecular engineering.
authors.affiliation: Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: O'Keeffe
authors.affiliation: Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.
authors.forename: Gongxian
authors.initials: G
authors.lastname: Liao
authors.affiliation: Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.
authors.forename: Cox
authors.initials: C
authors.lastname: Terhorst
authors.affiliation: Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
keywords: Inflammatory bowel disease (IBD); anti-inflammatory therapy; glycopeptide; nanofibers; self-assembled hydrogel