title: Endobronchial solitary fibrous tumor.
abstract: Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that appears primarily in the pleura and rarely in intrapulmonary or endobronchial topography. The authors report the case of a 47-year-old woman who presented obstructive respiratory symptoms for 4 years. The chest computed tomography and bronchoscopy showed an obstructive polypoid lesion located between the trachea and the left main bronchus associated with distal atelectasis of the left lung. A resection of the lesion was performed and, macroscopically, the mass was oval, encapsulated, and firm, measuring 2.3 × 1.7 × 1.5 cm. Histology revealed low-grade mesenchymal spindle cell neoplasm, with alternating cellularity, myxoid areas, and mature adipose tissue outbreaks, as well as blood vessels with irregular walls. The immunohistochemical study was positive for CD34, CD99, and BCL2. The diagnosis was SFT in an unusual topography. The patient's symptoms remitted after tumor excision, and no systemic problems were evident. SFTs primarily affect adults and often follow a benign course; however, their behavior is unpredictable. The presence of necrosis and mitotic activity may portend a poor prognosis. Endobronchial SFTs are rare but should be evaluated and monitored similar to SFTs at other sites, with a long-term follow-up.
authors.affiliation: Department of Pathology - Botucatu School of Medicine - Universidade Estadual Paulista "Julio de Mesquista Filho", Botucatu/SP - Brazil .
authors.forename: Cristiano Claudino
authors.initials: CC
authors.lastname: Oliveira
authors.affiliation: Department of Pathology - Botucatu School of Medicine - Universidade Estadual Paulista "Julio de Mesquista Filho", Botucatu/SP - Brazil .
authors.forename: Marcelo Padovani Toledo
authors.initials: MP
authors.lastname: de Moraes
authors.affiliation: Department of Laboratory Medicine and Pathology - Mayo Clinic., Phoenix/AZ, USA .
authors.forename: Thomas
authors.initials: T
authors.lastname: Colby
authors.affiliation: Department of Surgery and Orthopedics - Botucatu School of Medicine - Universidade Estadual Paulista "Julio de Mesquista Filho", Botucatu/SP - Brazil .
authors.forename: Gilmar Felisberto
authors.initials: GF
authors.lastname: Oliveira
authors.affiliation: Department of Surgery and Orthopedics - Botucatu School of Medicine - Universidade Estadual Paulista "Julio de Mesquista Filho", Botucatu/SP - Brazil .
authors.forename: Erica Nishida
authors.initials: EN
authors.lastname: Hasimoto
authors.affiliation: Department of Surgery and Orthopedics - Botucatu School of Medicine - Universidade Estadual Paulista "Julio de Mesquista Filho", Botucatu/SP - Brazil .
authors.forename: Daniele Cristina
authors.initials: DC
authors.lastname: Cataneo
authors.affiliation: Department of Surgery and Orthopedics - Botucatu School of Medicine - Universidade Estadual Paulista "Julio de Mesquista Filho", Botucatu/SP - Brazil .
authors.forename: Antônio José Maria
authors.initials: AJ
authors.lastname: Cataneo
authors.affiliation: Department of Pathology - Botucatu School of Medicine - Universidade Estadual Paulista "Julio de Mesquista Filho", Botucatu/SP - Brazil .
authors.forename: Julio
authors.initials: J
authors.lastname: De Faveri
keywords: Bronchi; Immunohistochemistry; Lung Neoplasms; Pathology; Solitary Fibrous Tumors