title: Historical Review of Glasses Used for Parenteral Packaging.
abstract: Glass has long been used for packaging precious liquids, in particular pharmaceuticals. Its unique combination of hermeticity, transparency, strength, and chemical durability make it the optimal material for such an important role. Today's life-saving drugs are stored in borosilicate glasses, which evolved from applications in microscope optics and thermometers. As the glass compositions improved, so did the methods used to shape them and the tests used to characterize them. While all of these advances improved the quality of the glass container and its ability to protect the contents, problems still exist such as delamination, cracks, and glass particulates. In addition to these issues, we review new developments in glass composition development, performance, and testing in the 21stcentury.
authors.affiliation: Corning Incorporated, Corning, NY schautra@corning.com.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Schaut
authors.affiliation: Corning Incorporated, Corning, NY.
authors.forename: W Porter
authors.initials: WP
authors.lastname: Weeks
mesh_terms: D004349:Drug Packaging / Q000266:history*; D004356:Drug Storage; D005898:Glass / Q000266:history* / Q000592:standards; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D019999:Pharmaceutical Solutions
chemical_list: D019999:Pharmaceutical Solutions
keywords: Delamination; Glass; Hydrolytic; Packaging; Parenteral; Review