title: Comparing the Effects of Agnugol and Metformin on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial.
abstract: BACKGROUND
  Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy and cause of oligomenorrhea in women.
  
  
  OBJECTIVE
  The present study was conducted with the aim to compare the effect of Agnugol and Metformin drugs on oligomenorrhea in patients with PCOS.
  
  
  METHODS
  This study was a clinical trial on 120 women with PCOS and had oligomenorrhea, referring to a gynaecology clinic Fatemieh, Hamadan city, Iran, 2015. Women were randomly divided into 2 groups using permutation blocks (getting the medications Agnugol and Metformin) and were treated with drugs Agnugol and Metformin for 3 months. Data collection included demographic questionnaire and check list was designed and completed before and at the end of interventions, by both groups. To analyse the data, descriptive statistics, chi-square tests, t-test, ANOVA with repeated measures was used.
  
  
  RESULTS
  The mean and SD of age was 39.45±4.60 for women taking Agnugol and 38.466±0.84 for those taking Metformin. Based on the results between the subjects, the two groups were not significantly different in terms of menstruation length, cycle intervals, or the number of pads, meaning that the two drugs had similar effects on menstrual cycle regulation, menstruation length and the number of pads. More side effects were reported in the group using Metformin.
  
  
  CONCLUSIONS
  Agnugol and Metformin drugs in the treatment of oligomenorrhea patients with PCOS have the same effect. Since Metformin is a chemical drug with side effects, Agnugol can be presented as its herbal alternative to treat oligomenorrhea.
authors.affiliation: Instructor, Faculty of Midwifery, School of Nursing and Midwifery, Hamadan University of Medical Sciences , Hamadan, Iran .
authors.forename: Arezoo
authors.initials: A
authors.lastname: Shayan
authors.affiliation: Assistant Professor, Mother and Child Care Research Center, Hamadan University of Medical Sciences , Hamadan, Iran .
authors.forename: Seyedeh Zahra
authors.initials: SZ
authors.lastname: Masoumi
authors.affiliation: Associate Professor, Mother and Child Care Research Center, Hamadan University of Medical Sciences , Hamadan, Iran .
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Shobeiri
authors.affiliation: Instructor, Faculty of Midwifery, School of Nursing and Midwifery, Hamadan University of Medical Sciences , Hamadan, Iran .
authors.forename: Shahin
authors.initials: S
authors.lastname: Tohidi
authors.affiliation: Instructor, Faculty of Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences , Hamadan, Iran .
authors.forename: Arash
authors.initials: A
authors.lastname: Khalili
keywords: Chemical drug; Endocrinopathy; Herbal drug; Menstruation