title: Aspirin Use Prior to Coronary Artery Bypass Grafting Surgery: a Systematic Review.
abstract: Aspirin use before coronary artery bypass graft (CABG) surgery has been a puzzling question for years. Controversy existed regarding the overall benefits vs. risk of pre-operative aspirin use and was translated to conflicting guidelines from major societies.
  
  
  
  Observational studies have suggested a reduced mortality with pre-operative aspirin use. A meta-analysis of randomized controlled trials showed increased risk of post-operative bleeding with aspirin, with no associated increased mortality risk. A recent large randomized controlled trial did not find a significant difference in bleeding risk or post-operative mortality with pre-CABG aspirin use. The results of available studies showed a beneficial effect with pre-CABG aspirin use by decreasing thrombotic complications and perioperative myocardial infarction, with an associated adverse risk of bleeding that did not affect mortality rates. Given overall benefit-risk assessment, we are in favor of pre-operative aspirin use in CABG patients.
authors.affiliation: Department of Medicine, Rochester General Hospital, Rochester, NY, USA.|Department of Cardiovascular Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: Elbadawi
authors.affiliation: Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205,, USA.
authors.forename: Marwan
authors.initials: M
authors.lastname: Saad
authors.affiliation: Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205,, USA. ramez.nairooz@gmail.com.
authors.forename: Ramez
authors.initials: R
authors.lastname: Nairooz
mesh_terms: D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000628:therapy*; D006801:Humans; D015201:Meta-Analysis as Topic; D009203:Myocardial Infarction / Q000139:chemically induced; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000139:chemically induced; D017410:Practice Guidelines as Topic; D011300:Preoperative Care; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Aspirin; Cardiac surgery; Coronary artery bypass graft; Pre-operative