title: Soy Soluble Polysaccharide as a Nanocarrier for Curcumin.
abstract: The complexation between soy soluble polysaccharide (SSPS) and curcumin at pH 7.0 and 4.0, as well as some physicochemical characteristics of the resultant complexes, was investigated. The encapsulation efficiency and loading amount of curcumin in the complexes at pH 4.0 reached 67.3% and 4.49 μg/mg SSPS, respectively. Ethanol-induced denaturation and structural unfolding of the protein fraction in SSPS was essential for complex formation. The complexation with curcumin resulted in aggregation of SSPS and the subsequent formation of compacted nanoparticles with curcumin as the core. The complexation greatly improved the heat stability and in vitro bioaccessibility of curcumin. In general, the encapsulation efficiency, heat stability, and bioaccessibility of curcumin in the complexes at pH 4.0 were better than those at pH 7.0. The findings are of importance for the development of food grade nanovehicles for enhanced water solubility, stability, and bioaccessibility of hydrophobic bioactives.
authors.affiliation: Department of Food Science and Technology, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Fei-Ping
authors.initials: FP
authors.lastname: Chen
authors.affiliation: Department of Food Science and Engineering, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Shi-Yi
authors.initials: SY
authors.lastname: Ou
authors.affiliation: Department of Food Science and Technology, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Food Science and Technology, South China University of Technology , Guangzhou 510640, People's Republic of China.|State Key Laboratory of Pulp and Paper Engineering, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Chuan-He
authors.identifier: http://orcid.org/0000-0002-8769-2040
authors.initials: CH
authors.lastname: Tang
mesh_terms: D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D010936:Plant Extracts; D011134:Polysaccharides; D003474:Curcumin
keywords: bioaccessibility; complexation; curcumin; nanocarrier; soy soluble polysaccharide (SSPS)