title: Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity.
abstract: Macrophages are phagocytic cells that participate in a broad range of cellular functions and they are key regulators of innate immune responses and inflammation. Mitochondria are highly dynamic endosymbiotic organelles that play key roles in cellular metabolism and apoptosis. Mounting evidence suggests that mitochondria are involved in the interplay between metabolism and innate immune responses. The ability of these organelles to alter the metabolic profile of a cell, thereby allowing an appropriate response to each situation, is crucial for the correct establishment of immune responses. Furthermore, mitochondria act as scaffolds for many proteins involved in immune signaling pathways and as such they are able to modulate the function of these proteins. Finally, mitochondria release molecules, such as reactive oxygen species, which directly regulate the immune response. In summary, mitochondria can be considered as core components in the regulation of innate immune signaling. Here we discuss the intricate relationship between mitochondria, metabolism, intracellular signaling, and innate immune responses in macrophages.
authors.affiliation: Macrophage Biology Group, School of Biology, Universitat de Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Tur
authors.affiliation: Macrophage Biology Group, School of Biology, Universitat de Barcelona, Barcelona, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Vico
authors.affiliation: Macrophage Biology Group, School of Biology, Universitat de Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Lloberas
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain; Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Zorzano
authors.affiliation: Macrophage Biology Group, School of Biology, Universitat de Barcelona, Barcelona, Spain. Electronic address: acelada@ub.edu.
authors.forename: A
authors.initials: A
authors.lastname: Celada
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000378:metabolism*; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D058847:Inflammasomes; D017382:Reactive Oxygen Species
keywords: Inflammasome; Macrophage; Metabolism; Mitochondria; Reactive oxygen species; Signal transduction