title: Association between Systemic Diseases and Endodontic Outcome: A Systematic Review.
abstract: BACKGROUND
  To date, the relationships between systemic diseases and endodontic treatment outcomes remain poorly studied. Thus, the purpose of this systematic review was to evaluate the relationship between host-modifying factors and their association with endodontic outcomes.
  
  
  METHODS
  Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies and gray literature of all relevant articles and textbooks were manually searched. There was no disagreement between the 2 reviewers.
  
  
  RESULTS
  Sixteen articles met the inclusion criteria with moderate to high risk of bias. There was no article with low risk of bias. Available scientific evidence remains inconclusive as to whether diabetes and/or cardiovascular disease(s) may be associated with endodontic outcomes. Human immunodeficiency virus and oral bisphosphonate did not appear to be associated with endodontic outcomes.
  
  
  CONCLUSIONS
  Although additional well-designed longitudinal clinical studies are needed, the results of this systematic review suggest that some systemic diseases may be correlated with endodontic outcomes.
authors.affiliation: Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio. Electronic address: aaminoshariae@yahoo.com.
authors.forename: Anita
authors.initials: A
authors.lastname: Aminoshariae
authors.affiliation: Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio.
authors.forename: James C
authors.initials: JC
authors.lastname: Kulild
authors.affiliation: Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Andre
authors.initials: A
authors.lastname: Mickel
authors.affiliation: Department of Endodontics, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Ashraf F
authors.initials: AF
authors.lastname: Fouad
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000150:complications; D002318:Cardiovascular Diseases / Q000150:complications; D003788:Dental Pulp Diseases / Q000150:complications* / Q000601:surgery; D048909:Diabetes Complications / Q000150:complications; D015658:HIV Infections / Q000150:complications; D006801:Humans; D016896:Treatment Outcome
keywords: Cardiovascular disease; diabetes; endodontic outcome; human immunodeficiency virus; hypertension; medical conditions; systemic disease