title: Peripherally inserted central catheter-related complications in cancer patients: a prospective study of over 50,000 catheter days.
abstract: OBJECTIVE
  To evaluate incidence and risk factors of peripherally inserted central catheter (PICC)-related complications in cancer patients.
  
  
  METHODS
  A prospective, multicenter, cohort study of cancer patients with PICC insertion was performed from February 1, 2013 to April 24, 2014. All patients were monitored in clinic until PICCs were removed. The primary endpoint was PICC removal due to complications. Patient-, catheter- and insertion-related factors were analyzed in univariable and multivariable logistic regression analysis to identify significant independent risk factors for PICC-related complications.
  
  
  RESULTS
  There were 477 cancer patients included, for a total of 50,841 catheter-days. Eighty-one patients (17.0%) developed PICC-related complications, with an incidence of 1.59 per 1000 catheter days. Thirty-six (7.5%) PICCs were removed because of complications. The most common complications were skin allergy (4.6%), catheter occlusion (3.4%) and accidental withdrawal (2.3%). Nine (1.9%) patients developed symptomatic upper extremity deep venous thrombosis (UEDVT) and central line associated bloodstream infection (CLABSI) was shown in six (1.3%) PICCs with an infection rate 0.12 per 1000 catheter days. In multivariable analysis, body mass index (BMI) >25 (odds ratio, 2.09; 95% confidence interval, 1.26-3.47, p = 0.004) was shown to be a significant risk factor for PICC complications.
  
  
  CONCLUSIONS
  Cancer patients with BMI greater than 25 were more likely to have PICC complications.
authors.affiliation:  Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China.
authors.forename: Junren
authors.initials: J
authors.lastname: Kang
authors.affiliation:  Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation:  Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Sun
authors.affiliation:  Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China.
authors.forename: Ruibin
authors.initials: R
authors.lastname: Ge
authors.affiliation:  Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Li
authors.affiliation:  Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing - China.
authors.forename: Enling
authors.initials: E
authors.lastname: Ma
authors.affiliation:  Department of Nursing, NanFang Hospital, Southern Medical University, Guangzhou - China.
authors.forename: Qingxia
authors.initials: Q
authors.lastname: Su
authors.affiliation:  Department of Nursing, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan - China.
authors.forename: Fang
authors.initials: F
authors.lastname: Cheng
authors.affiliation:  Department of Nursing, Jiangxi Cancer Hospital, Nanchang - China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Hong
authors.affiliation:  Department of Nursing, The Second Affiliated Hospital, ShanXi Medical University, Taiyuan - China.
authors.forename: Yuanjuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation:  Department of Nursing, First hospital of Shijiazhuang, HeBei Medical University, Shijiazhuang - China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Lei
authors.affiliation:  Department of Nursing, XiJing Hospital, Fourth Military Medical University, Xian - China.
authors.forename: Xinchuan
authors.initials: X
authors.lastname: Wang
authors.affiliation:  Department of Nursing, The First Affiliated Hospital, ZheJiang University, Hangzhou - China.
authors.forename: Aiyun
authors.initials: A
authors.lastname: Jin
authors.affiliation:  Department of Nursing, XiangYa Hospital, Central South University, Changsha - China.
authors.forename: Wanli
authors.initials: W
authors.lastname: Liu
mesh_terms: D061605:Administration, Intravenous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D061807:Catheter Obstruction; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002406:Catheterization, Peripheral / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling / Q000009:adverse effects*; D062905:Central Venous Catheters / Q000009:adverse effects*; D002681:China / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016017:Odds Ratio; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D056824:Upper Extremity Deep Vein Thrombosis / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents