title: New Consensus Definitions for Sepsis and Septic Shock: Implications for Treatment Strategies and Drug Development?
abstract: Sepsis continues to escape a precise diagnostic definition. The most recent consensus definition, termed Sepsis-3, highlights the importance of the maladaptive and potentially life-threatening host response to infection. After briefly reviewing the history and epidemiology of sepsis, we go on to describe some of the challenges encountered when classifying such a heterogenous disease state. In the context of these new definitions for sepsis and septic shock, we explore current and potentially novel therapies, and conclude by mentioning some of the controversies of this most recent framework.
authors.affiliation: Imperial School of Anaesthesia, London, UK. michael.berry@doctors.org.uk.
authors.forename: Michael
authors.identifier: http://orcid.org/0000-0002-0869-9608
authors.initials: M
authors.lastname: Berry
authors.affiliation: Adult ICU, Royal Brompton and Harefield NHS Foundation Trust, London, UK.|Section of Anaesthesia, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK.
authors.forename: Brijesh V
authors.initials: BV
authors.lastname: Patel
authors.affiliation: Section of Anaesthesia, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK.|Centre for Perioperative Medicine and Critical Care Research, Imperial College Healthcare NHS Trust, London, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Brett
mesh_terms: D032921:Consensus; D006801:Humans; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology