title: Lymph node metastasis of presacral ependymoblastoma in a young child.
abstract: Ependymoblastoma presenting outside the brain is rare in children. The overwhelming majority of presacral ependymal tumors are of the benign myxpapillary type. We present a case of ependymoblastoma in the presacral region of a four-year old child. The patient presented with a presacral mass and ipsilateral inguinal lymph node metastasis. Both masses revealed histologic and immunophenotypic features of ependymoblastoma associated with myxoid areas and high Ki-67 proliferation index. The masses were excised and the patient remained well for a year after diagnosis with no other therapy. This report emphasizes ependymoblastoma as rare entity in the differential diagnosis of presacral tumors in children and, up to our knowledge, the first report of inguinal lymph node metastasis of ependymoblastoma.
authors.affiliation: Research Center, Saudi Human Genome Laboratory, King Fahad Medical City, Saudi Arabia; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. Electronic address: malthagafi@kfmc.med.sa.
authors.forename: Malak
authors.initials: M
authors.lastname: Abedalthagafi
authors.affiliation: Research Center, Saudi Human Genome Laboratory, King Fahad Medical City, Saudi Arabia.
authors.forename: Sadeq W
authors.initials: SW
authors.lastname: Aldandan
authors.affiliation: Department of Hematology-Oncology, King Fahad Medical City, Riyadh, Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Alrayis
authors.affiliation: Department of Pathology, Children's Mercy Hospital, Kansas City, MO, USA.
authors.forename: Atif A
authors.initials: AA
authors.lastname: Ahmed
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: ETMR; Ependymoblastoma; LIN28; Metastasis; Presacral mass