title: Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability.
abstract: We evaluated copy number variation (CNV) for four genes in rat strains differing in nervous system excitability. rpl13a copy number is significantly reduced in hippocampus and bone marrow in rats with a high excitability threshold and stress. The observed phenomenon may be associated with a role for rpl13a in lipid metabolism.
authors.affiliation: LUKE/BI Plant Genome Dynamics, Institute of Biotechnology and Viikki Plant Science Centre, University of Helsinki, P.O. Box 65, FI-00014 Helsinki, Finland. Electronic address: ruslan.kalendar@mail.ru.
authors.forename: Ruslan
authors.initials: R
authors.lastname: Kalendar
authors.affiliation: Laboratory of Molecular Cytogenetics and Karyology, Institute of Botany, Czech Academy of Sciences, Zámek 1, CZ-25243 Průhonice, Czech Republic. Electronic address: alexander.belyayev@ibot.cas.cz.
authors.forename: Alexander
authors.initials: A
authors.lastname: Belyayev
authors.affiliation: Laboratory of Genetics of Higher Nervous Activity, Pavlov Institute of Physiology of the Russian Academy of Science, Nab. Makarova, 6, 199034 Saint Petersburg, Russia. Electronic address: polosataya2@mail.ru.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Zachepilo
authors.affiliation: Laboratory of Genetics of Higher Nervous Activity, Pavlov Institute of Physiology of the Russian Academy of Science, Nab. Makarova, 6, 199034 Saint Petersburg, Russia. Electronic address: aivaido@mail.ru.
authors.forename: Alexander
authors.initials: A
authors.lastname: Vaido
authors.affiliation: Laboratory of Genomic and Proteomic Research, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia. Electronic address: DMaidaniuk@kantiana.ru.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Maidanyuk
authors.affiliation: LUKE/BI Plant Genome Dynamics, Institute of Biotechnology and Viikki Plant Science Centre, University of Helsinki, P.O. Box 65, FI-00014 Helsinki, Finland; Green Technology, Natural Resources Institute Finland (Luke), Latokartanonkaari 9, FI-00790 Helsinki, Finland. Electronic address: alan.schulman@helsinki.fi.
authors.forename: Alan H
authors.initials: AH
authors.lastname: Schulman
authors.affiliation: Laboratory of Genetics of Higher Nervous Activity, Pavlov Institute of Physiology of the Russian Academy of Science, Nab. Makarova, 6, 199034 Saint Petersburg, Russia. Electronic address: dyuzhikova@mail.ru.
authors.forename: Natalia
authors.initials: N
authors.lastname: Dyuzhikova
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000502:physiology; D000071080:Cortical Excitability / Q000235:genetics / Q000502:physiology; D056915:DNA Copy Number Variations / Q000235:genetics*; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D009424:Nervous System Physiological Phenomena / Q000235:genetics*; D051381:Rats; D012269:Ribosomal Proteins / Q000235:genetics*
chemical_list: D012269:Ribosomal Proteins; C489210:Rpl13a protein, rat
keywords: Bone marrow; Copy number variation (CNV); Hippocampus; Nervous system excitability; Quantitative real-time multicolor multiplex PCR (qmPCR); Rat