title: Morphologic Patterns Formed by the Anomalous Fibers Occurring Along the Anterior Capsule of the Crystalline Lens in People With the Long Anterior Zonule Trait.
abstract: People with the long anterior zonule (LAZ) trait, which may have prevalence near 2%, have zonular fibers that extend more central than usual along the anterior capsule of the crystalline lens. The anomalous fibers can be observed in vivo with clinical slit lamp biomicroscopy after pharmacologic pupil dilation, and although minimally studied, the LAZ trait may have importance to glaucoma, retinal degeneration, and cataract surgery. To further characterize LAZ morphology, a custom computer program was used to trace LAZ fibers seen on retro-illumination photos acquired during previous study at an academic, urban eye care facility in Chicago, IL. There were 59 African-Americans (54 female; median age = 70 years, 53-91 years) included in the analysis. After initial review of the zonule tracings, we identified three basic LAZ patterns. We called one pattern (47% of right eyes) a "non-segmental LAZ pattern," which was predominated by fibers that could be visually traced to the dilated pupil border where they became obscured by the iris. Another pattern (35% of right eyes), the "segmental LAZ pattern," was predominated by fibers that appeared to terminate abruptly without detectable extension to the pupil border. The third pattern (18% of right eyes), the "mixed LAZ pattern," had a more equivalent mixture of the other two fiber morphologies. Compared to the "non-segmental" group, the "segmental" LAZ eyes had smaller central zonule-free zones (P < 0.0001), and they tended to exhibit fewer LAZ fibers (P = 0.07). These data improve understanding of LAZ clinical anatomy and may be helpful to future investigation. Anat Rec, 300:1336-1347, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Clinical Education, Illinois College of Optometry, Illinois Eye Institute, Chicago, Illinois.|Department of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois.|Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois.
authors.forename: Daniel K
authors.identifier: http://orcid.org/0000-0002-2876-1595
authors.initials: DK
authors.lastname: Roberts
authors.affiliation: Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Clinical Education, Illinois College of Optometry, Illinois Eye Institute, Chicago, Illinois.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Morettin
authors.affiliation: Department of Clinical Education, Illinois College of Optometry, Illinois Eye Institute, Chicago, Illinois.
authors.forename: Tricia L
authors.initials: TL
authors.lastname: Newman
authors.affiliation: Department of Clinical Education, Illinois College of Optometry, Illinois Eye Institute, Chicago, Illinois.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Roberts
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois.
authors.forename: Jacob T
authors.initials: JT
authors.lastname: Wilensky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000033:anatomy & histology*; D007905:Lens Diseases / Q000473:pathology*; D008022:Ligaments / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
keywords: cataract; crystalline lens; glaucoma; long anterior zonules; pigment dispersion