title: The effects of topical carbonic anhydrase inhibitor in treatment of nystagmus.
abstract: OBJECTIVE
  To evaluate the effects of topical carbonic anhydrase inhibitor (CAI), brinzolamide (Azopt), for treatment of nystagmus patients.
  
  
  METHODS
  Patients who used Brinzolamide for treatment of nystagmus were retrospectively analyzed. 23 patients were included in this study. The patients' diagnosis were idiopathic infantile nystagmus 18 (78.2%) and oculocutaneous albinism in 5 (21.8%). Azopt eye drop was used in both eyes, 3 times a day. Detailed eye examination in all of the patients before treatment and repeated at the end of the first week after treatment. SPSS 16.0 computer program was used for evaluation of DATAs.
  
  
  RESULTS
  The mean follow-up was 32 ± 28 months. 23 patients 15 (65.2%) were male and 8 (34.7%) were female and the mean age was 12.6 ± 5.5. Before the management of topical brinzolamide, abnormal head position (AHP) were observed in 18 patients. After that we found reduction of nystagmus in 5 (22.7%) of the patients, increase in vision in 9 (40.9%) and reduced AHP in 18.3%. There is no identified change in 4 (18.1%).
  
  
  CONCLUSIONS
  The medical treatment of nystagmus with topical brinzolamide was found effective in our series but, wider series and longer follow-up studies are needed.
authors.affiliation: Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sokak No:2 Beyoglu, Istanbul, Turkey. ebrudemet@hotmail.com.
authors.forename: Ebru Demet
authors.initials: ED
authors.lastname: Aygit
authors.affiliation: Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sokak No:2 Beyoglu, Istanbul, Turkey.
authors.forename: Osman Bulut
authors.initials: OB
authors.lastname: Ocak
authors.affiliation: Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sokak No:2 Beyoglu, Istanbul, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: İnal
authors.affiliation: Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sokak No:2 Beyoglu, Istanbul, Turkey.
authors.forename: Korhan
authors.initials: K
authors.lastname: Fazıl
authors.affiliation: Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sokak No:2 Beyoglu, Istanbul, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Akar
authors.affiliation: Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sokak No:2 Beyoglu, Istanbul, Turkey.
authors.forename: Birsen
authors.initials: B
authors.lastname: Gokyigit
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005133:Eye Movements / Q000187:drug effects / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009759:Nystagmus, Pathologic / Q000188:drug therapy* / Q000503:physiopathology; D009883:Ophthalmic Solutions; D012189:Retrospective Studies; D013449:Sulfonamides / Q000008:administration & dosage*; D013843:Thiazines / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013843:Thiazines; C111827:brinzolamide
keywords: Carbonic anhydrase inhibitor; Infantile Nystagmus Syndrome; Nystagmus; Oculocutaneos albinism