title: GPR55: a new promising target for metabolism?
abstract: GPR55 is a G-protein-coupled receptor (GPCR) that has been identified as a new cannabinoid receptor. Given the wide localization of GPR55 in brain and peripheral tissues, this receptor has emerged as a regulator of multiple biological actions. Lysophosphatidylinositol (LPI) is generally accepted as the endogenous ligand of GPR55. In this review, we will focus on the role of GPR55 in energy balance and glucose metabolism. We will summarize its actions on feeding, nutrient partitioning, gastrointestinal motility and insulin secretion in preclinical models and the scarce data available in humans. The potential of GPR55 to become a new pharmaceutical target to treat obesity and type 2 diabetes, as well as the foreseeing difficulties are also discussed.
authors.affiliation: Instituto de Investigaciones Sanitarias (IDIS)CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Santiago de Compostela, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Tudurí
authors.affiliation: Instituto de Investigaciones Sanitarias (IDIS)CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Santiago de Compostela, Spain.|Department of PhysiologyCIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Imbernon
authors.affiliation: Instituto de Investigaciones Sanitarias (IDIS)CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Santiago de Compostela, Spain.|Department of PhysiologyCIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Rene Javier
authors.initials: RJ
authors.lastname: Hernández-Bautista
authors.affiliation: Instituto de Investigaciones Sanitarias (IDIS)CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Santiago de Compostela, Spain.|Department of PhysiologyCIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Tojo
authors.affiliation: Department of Clinical ScienceKG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway.
authors.forename: Johan
authors.initials: J
authors.lastname: Fernø
authors.affiliation: Instituto de Investigaciones Sanitarias (IDIS)CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Santiago de Compostela, Spain.|Department of PhysiologyCIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
authors.affiliation: Instituto de Investigaciones Sanitarias (IDIS)CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Santiago de Compostela, Spain.|Department of PhysiologyCIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Nogueiras
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002186:Cannabinoids / Q000378:metabolism / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D055808:Drug Discovery; D004734:Energy Metabolism / Q000187:drug effects; D005786:Gene Expression Regulation; D006801:Humans; D008024:Ligands; D058990:Molecular Targeted Therapy; D009928:Organ Specificity / Q000235:genetics; D043882:Receptors, Cannabinoid / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D012377:Rodentia
chemical_list: D002186:Cannabinoids; C524885:GPR55 protein, human; D008024:Ligands; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled
keywords: GPR55; adipose tissue; cannabinoids; diabetes II