title: Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey.
abstract: BACKGROUND
  To prepare for a future clinical trial for improving the long-term prognosis of patients with uterine leiomyosarcoma (ULMS), we conducted a multi-institutional survey in the Tohoku region of Japan.
  
  
  METHODS
  We conducted a retrospective cohort study between 2011 and 2014 in member institutions of the Tohoku Translational Research Center Development Network.
  
  
  RESULTS
  A total of 53 patients with ULMS were registered in 31 institutions for the present survey. The median patient age was 56 years, 67.9% of the patients were postmenopausal, 88.7% had a performance status of 0 or 1, and only 6 patients (11.3%) showed preoperative evidence of malignancy. Although retroperitoneal lymphadenectomy was performed in only 26.4% of patients, 64.2% patients were identified as having FIGO stage 1 disease; 73.6% were eligible to undergo complete surgery. Among 36 patients who were treated with postoperative chemotherapy, 28 (77.8%) received docetaxel and gemcitabine combination therapy. The most frequent recurrence site was the lungs, and the median progression-free survival of all enrolled patients was 11.7 months. However, the median progression-free survival and the median overall survival in patients with stages III and IV disease were 3.4 and 11.4 months, respectively.
  
  
  CONCLUSIONS
  Although ULMS was associated with a high rate of complete or optimal surgery, the long-term prognosis was poor. Effective postoperative therapy should be developed to improve the long-term prognosis of patients with ULMS.
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Tokunaga
authors.affiliation: Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Takahashi
authors.affiliation: Department of Obstetrics and Gynecology, Omagari Kousei Medical Center, 8-65 Omagaritori-machi, Daisen, Omagari, Akita, 014-0027, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Obstetrics and Gynecology, Iwaki Kyoritsu Hospital, 16 Uchigomimaya-machi, Iwaki, Fukushima, 973-8402, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Honda
authors.affiliation: Department of Obstetrics and Gynecology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan.
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Shoji
authors.affiliation: Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Sugiyama
authors.affiliation: Department of Gynecology, Miyagi Cancer Center, 47-1 Medeshimashiote, Natori, Miyagi, 981-1293, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Yamada
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki National Hospital, 1 Tomino-cho, Hirosaki, Aomori, 036-8545, Japan.
authors.forename: Tomoe
authors.initials: T
authors.lastname: Tando
authors.affiliation: Department of Obstetrics and Gynecology, Sendai Medical Center, 2-8-8 Miyagino, Miyagino-ku, Sendai, Miyagi, 983-8520, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Yoshinaga
authors.affiliation: Department of Obstetrics and Gynecology, Nakadori General Hospital, 3-15 Minamidorimisono-cho, Akita, Akita, 010-8577, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Kagabu
authors.affiliation: Department of Obstetrics and Gynecology, Sendai City Hospital, 1-1-1 Asutonagamachi, Taihaku-ku, Sendai, Miyagi, 982-8502, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Otsuki
authors.affiliation: Department of Obstetrics and Gynecology, Takeda General Hospital, 3-27 Yamaga-machi, Aizuwakamatsu, Fukushima, 965-8585, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Kin
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Yokoyama
authors.affiliation: Department of Obstetrics and Gynecology, Osaki Citizen Hospital, 3-8-1 Furukawa, Osaki, Miyagi, 989-6183, Japan.
authors.forename: Satoshige
authors.initials: S
authors.lastname: Wagatsuma
authors.affiliation: Department of Obstetrics and Gynecology, Iwate Prefectural Chubu Hospital, 17-10 Murasakino, Kitakami, Iwate, 024-8507, Japan.
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Obstetrics and Gynecology, Japanese Red Cross Akita Hospital, 222-1 Kamikitatesaruta, Akita, Akita, 010-1495, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Sato
authors.affiliation: Department of Obstetrics and Gynecology, Aomori Kousei Hospital, 488-1 Shinjyo, Aomori, Aomori, 038-0042, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oishi
authors.affiliation: Department of Obstetrics and Gynecology, Japanese Red Cross Ishinomaki Hospital, 71 Hebita, Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Department of Obstetrics and Gynecology, Nihonkai General Hospital, 30 Akiho-cho, Sakata, Yamagata, 998-8501, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hayasaka
authors.affiliation: Department of Obstetrics and Gynecology, Noshiro Kousei Medical Center, Ochiai, Akita, Noshiro, 016-0014, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Matsui
authors.affiliation: Department of Obstetrics and Gynecology, Hachinohe City Hospital, 1 Bisyamontai, Hachinohe, Aomori, Tamukai-aza, 031-8555, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Imai
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishigori
authors.affiliation: Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.|Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimokawa
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.affiliation: Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. ywatanabe@hosp.tohoku-mpu.ac.jp.|Department of Obstetrics and Gynecology, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro, Miyagino-Ku, Sendai, Miyagi, 983-8512, Japan. ywatanabe@hosp.tohoku-mpu.ac.jp.
authors.forename: Yoh
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018572:Disease-Free Survival; D000077143:Docetaxel; D005260:Female; D006306:Health Surveys; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007890:Leiomyosarcoma / Q000473:pathology*; D008197:Lymph Node Excision / Q000706:statistics & numerical data; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D043823:Taxoids / Q000008:administration & dosage; D014594:Uterine Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D000093542:Gemcitabine
keywords: Retrospective survey; Tohoku region; Uterine leiomyosarcoma