title: Cannabidiol: an alternative therapeutic agent for oral mucositis?
abstract: OBJECTIVE
  Chemo- and radiotherapy are therapeutic modalities often used in patients with malignant neoplasms. They kill tumour cells but act on healthy tissues as well, resulting in adverse effects. Oral mucositis is especially of concern, due to the morbidity that it causes. We reviewed the literature on the etiopathogenesis of oral mucositis and the activity of cannabidiol, to consider the possibility of its use for the prevention and treatment of oral mucositis.
  
  
  METHODS
  We searched the PubMed database and selected complete articles published in English that met the inclusion criteria for the period 1998-2016. The search terms 'cannabinoids', 'cannabidiol', 'oxidative stress', 'antioxidants' and 'oral mucositis' were used.
  
  
  CONCLUSIONS
  The control of oxidative stress may prevent and alleviate oral mucositis. Studies have demonstrated that cannabidiol is safe to use and possesses antioxidant, anti-inflammatory and analgesic properties.
  
  
  CONCLUSIONS
  The literature on the use of cannabidiol in dentistry is still scarce. Studies investigating the use of cannabidiol in oral mucositis and other oxidative stress-mediated side effects of chemotherapy and radiotherapy on the oral mucosa should be encouraged.
authors.affiliation: Division of Oral Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.|Division of Oral Medicine, Paranaense University (UNIPAR), Francisco Beltrão, Brazil.
authors.forename: L F
authors.initials: LF
authors.lastname: Cuba
authors.affiliation: Division of Oral Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
authors.forename: F G
authors.initials: FG
authors.lastname: Salum
authors.affiliation: Division of Oral Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
authors.forename: K
authors.initials: K
authors.lastname: Cherubini
authors.affiliation: Division of Oral Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
authors.forename: M A Z
authors.identifier: http://orcid.org/0000-0003-1104-5477
authors.initials: MAZ
authors.lastname: Figueiredo
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002185:Cannabidiol / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D018384:Oxidative Stress / Q000187:drug effects*; D011832:Radiation Injuries / Q000188:drug therapy; D013280:Stomatitis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D002185:Cannabidiol
keywords: antioxidants; cannabidiol; cannabinoids; oral mucositis; oxidative stress