title: Palladium-Catalyzed Double-Isocyanide Insertion via Oxidative N-O Cleavage of Acetyl Oximes: Syntheses of 2H-Pyrrol-2-imines.
abstract: The palladium-catalyzed reaction of acetyl oximes with isocyanides was developed for the synthesis of 2H-pyrrol-2-imines. The key steps were (i) generation of an enamido-palladium(II) species, (ii) migratory double-isocyanide insertion, and (iii) cyclization. The scope of the synthesis of some 2H-pyrrol-2-imines was extended to the synthesis 1H-pyrrole-2,3-dione/1H-benzo[g]indole-2,3-dione derivatives via acid hydrolysis in a sequential one-pot manner.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University , No. 100, Shih-Chuan 1st Road, Sanmin District, Kaohsiung City, 807 Taiwan.
authors.forename: Gopal Chandru
authors.identifier: 0000-0003-0149-5423
authors.initials: GC
authors.lastname: Senadi
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University , No. 100, Shih-Chuan 1st Road, Sanmin District, Kaohsiung City, 807 Taiwan.
authors.forename: Ting-Yi
authors.initials: TY
authors.lastname: Lu
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University , No. 100, Shih-Chuan 1st Road, Sanmin District, Kaohsiung City, 807 Taiwan.
authors.forename: Ganesh Kumar
authors.initials: GK
authors.lastname: Dhandabani
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University , No. 100, Shih-Chuan 1st Road, Sanmin District, Kaohsiung City, 807 Taiwan.|Department of Medical Research, Kaohsiung Medical University Hospital , No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung City, 807 Taiwan.
authors.forename: Jeh-Jeng
authors.identifier: 0000-0002-3148-1885
authors.initials: JJ
authors.lastname: Wang