title: Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017.
abstract: Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2016/17 influenza vaccine effectiveness (VE) against dominant influenza A(H3N2) viruses considered antigenically matched to the clade 3C.2a vaccine strain. Sequence analysis revealed substantial heterogeneity in emerging 3C.2a1 variants by province and over time. Adjusted VE was 42% (95% confidence interval: 18-59%) overall, with variation by province. Interim virological and VE findings reported here warrant further investigation to inform potential vaccine reformulation.
authors.affiliation: British Columbia Centre for Disease Control, Vancouver, Canada.|University of British Columbia, Vancouver, Canada.
authors.forename: Danuta M
authors.initials: DM
authors.lastname: Skowronski
authors.affiliation: British Columbia Centre for Disease Control, Vancouver, Canada.
authors.forename: Catharine
authors.initials: C
authors.lastname: Chambers
authors.affiliation: British Columbia Centre for Disease Control, Vancouver, Canada.
authors.forename: Suzana
authors.initials: S
authors.lastname: Sabaiduc
authors.affiliation: University of Calgary, Calgary, Canada.
authors.forename: James A
authors.initials: JA
authors.lastname: Dickinson
authors.affiliation: Public Health Ontario, Toronto, Canada.
authors.forename: Anne-Luise
authors.initials: AL
authors.lastname: Winter
authors.affiliation: Institut National de Santé Publique du Québec (National Institute of Health of Quebec), Québec, Canada.|Laval University, Quebec, Canada.|Centre Hospitalier Universitaire de Québec (University Hospital Centre of Quebec), Québec, Canada.
authors.forename: Gaston
authors.initials: G
authors.lastname: De Serres
authors.affiliation: Alberta Provincial Laboratory, Edmonton, Canada.|University of Alberta, Edmonton, Canada.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Drews
authors.affiliation: British Columbia Centre for Disease Control, Vancouver, Canada.|University of British Columbia, Vancouver, Canada.
authors.forename: Agatha
authors.initials: A
authors.lastname: Jassem
authors.affiliation: Public Health Ontario, Toronto, Canada.|University of Toronto, Toronto, Canada.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Gubbay
authors.affiliation: Institut National de Santé Publique du Québec (National Institute of Health of Quebec), Québec, Canada.
authors.forename: Hugues
authors.initials: H
authors.lastname: Charest
authors.affiliation: British Columbia Centre for Disease Control, Vancouver, Canada.|University of British Columbia, Vancouver, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Balshaw
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bastien
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: British Columbia Centre for Disease Control, Vancouver, Canada.|University of British Columbia, Vancouver, Canada.
authors.forename: Mel
authors.initials: M
authors.lastname: Krajden
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D018571:Sentinel Surveillance; D017422:Sequence Analysis, DNA; D014611:Vaccination / Q000706:statistics & numerical data; D064166:Vaccine Potency; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines
keywords: effectiveness; influenza; influenza virus; influenza-like illness - ILI; vaccine-preventable diseases; vaccines and immunisation