title: Comparison of Histologic Core Portions Acquired from a Core Biopsy Needle and a Conventional Needle in Solid Mass Lesions: A Prospective Randomized Trial.
abstract: OBJECTIVE
  The superiority of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) over EUS-guided fine needle aspiration (EUS-FNA) remains controversial. Given the lack of studies analyzing histologic specimens acquired from EUS-FNB or EUS-FNA, we compared the proportion of the histologic core obtained from both techniques.
  
  
  METHODS
  A total of 58 consecutive patients with solid mass lesions were enrolled and randomly assigned to the EUS-FNA or EUS-FNB groups. The opposite needle was used after the failure of core tissue acquisition using the initial needle with up to three passes. Using computerized analyses of the scanned histologic slide, the overall area and the area of the histologic core portion in specimens obtained by the two techniques were compared.
  
  
  RESULTS
  No significant differences were identified between the two groups with respect to demographic and clinical characteristics. Fewer needle passes were required to obtain core specimens in the FNB group (p<0.001). There were no differences in the proportion of histologic core (11.8%±19.5% vs 8.0%±11.1%, p=0.376) or in the diagnostic accuracy (80.6% vs 81.5%, p=0.935) between two groups.
  
  
  CONCLUSIONS
  The proportion of histologic core and the diagnostic accuracy were comparable between the FNB and FNA groups. However, fewer needle passes were required to establish an accurate diagnosis in EUS-FNB.
authors.affiliation: Department of Internal Medicine, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Ban Seok
authors.initials: BS
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Chang-Min
authors.initials: CM
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Jung
authors.affiliation: Department of Pathology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Jang
authors.affiliation: Department of Pathology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Han Ik
authors.initials: HI
authors.lastname: Bae
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062005:Biopsy, Large-Core Needle / Q000379:methods / Q000706:statistics & numerical data*; D003938:Diagnostic Techniques, Digestive System / Q000706:statistics & numerical data*; D004067:Digestive System Neoplasms / Q000175:diagnosis* / Q000473:pathology; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods / Q000706:statistics & numerical data*; D019160:Endosonography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
keywords: Core tissue; Endoscopic ultrasound-guided fine needle aspiration; Endoscopic ultrasound-guided fine needle biopsy; Endosonography; Tissue sampling