title: Prognostic significance of neutrophil-to-lymphocyte ratio in cervical cancer: A systematic review and meta-analysis of observational studies.
abstract: OBJECTIVE
  The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in cervical cancer are controversial. We conducted this meta-analysis to obtain a more accurate assessment of prognostic significance of NLR in cervical cancer.
  
  
  RESULTS
  A total of 9 studies, consisting of 2,804 patients, were selected in this meta-analysis. Our pooled results showed that high pre-treatment NLR level was significantly associated with poorer overall survival (HR: 1.88, 95% CI 1.30-2.73) and shorter progression free survival (HR 1.65, 95% CI 1.18-2.29). Additionally, increased NLR was also significantly correlated with tumor size (OR 2.05, 95% CI 1.14-3.65), advanced FIGO stage (OR 2.12, 95% CI1.28-3.49) and lymph node involvement (OR 2.24, 95% CI 1.65-3.04).
  
  
  METHODS
  We conducted a systematic literature search using the electronic databases PubMed, Web of Science, and Embase up to May 2016.Statistical analysis was performed using Stata 10.0.
  
  
  CONCLUSIONS
  Elevated pretreatment NLR could serve as a predicative factor of poor prognosis for cervical cancer patients.
authors.affiliation: Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Qi-Tao
authors.initials: QT
authors.lastname: Huang
authors.affiliation: Southern Medical University, Guangzhou, 510515, China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Man
authors.affiliation: Southern Medical University, Guangzhou, 510515, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Hu
authors.affiliation: Southern Medical University, Guangzhou, 510515, China.
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Yang
authors.affiliation: Southern Medical University, Guangzhou, 510515, China.
authors.forename: Yue-Mei
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhong
authors.affiliation: Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Yu
mesh_terms: D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology*; D064887:Observational Studies as Topic; D011379:Prognosis; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology
keywords: cervical cancer; inflammatory; lymphocyte; neutrophil; prognosis