title: Intravoxel incoherent motion diffusion-weighted imaging of bone marrow in patients with acute myeloid leukemia: a pilot study of prognostic value.
abstract: To investigate the value of intravoxel incoherent motion (IVIM) parameters in evaluation of prognosis in patients with acute myeloid leukemia (AML) before treatment.
  
  
  
  Fifty-three patients before standard chemotherapy underwent MRI scans at 1.5 Tesla using conventional diffusion weighted imaging (DWI) and IVIM (b = 0, 10, 25, 50, 100, 200, 400, 600, 800, 1000, 1200 s/mm2) in the sagittal plane covering the lumbar bone marrow. The IVIM parameters (perfusion fraction [f], molecular diffusion coefficient [D], and perfusion-related D [D*] and apparent diffusion coefficient (ADC) were extracted from the bone marrow images. All patients were divided into complete remission (CR) and nonremission (NR) group according to the treatment response.
  
  
  
  All patients underwent the first remission induction chemotherapy, with 33 patients achieved CR and 20 patients achieved NR. The ADC values were not significant different between the two groups (P = 0.118). However, D value of CR group was significantly higher (P = 0.010), and f value of CR group was significantly lower (P = 0.021) than those of NR group. D* values had no significant differences between the two groups (P = 0.955). The D and f values were significant prognostic factors of AML after controlling for potential confounding factors (age, gender and smoking). Using receiver operator characteristic analysis, the area under the curve of D and f were 0.759 and 0.666, respectively, in evaluating prognosis of AML before treatment.
  
  
  
  There were significant differences in IVIM parameters between CR and NR patients of AML before treatment, and the D and f could play a potential role in prognosticating patients with AML.
  
  
  
  1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:476-482.
authors.affiliation: Radiology Department, 2nd hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Niu
authors.affiliation: Department of Stomatology, 2nd hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Li
authors.affiliation: Clinical Molecular Biology Lab, the 2nd Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Radiology Department, 2nd hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Wu
authors.affiliation: Radiology Department, 2nd hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Gong
authors.affiliation: Clinical Molecular Biology Lab, the 2nd Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Huang
authors.affiliation: GE Healthcare, Life Science, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Neurology Department, the 2nd Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D060828:Induction Chemotherapy; D015470:Leukemia, Myeloid, Acute / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009038:Motion; D010865:Pilot Projects; D011379:Prognosis; D012372:ROC Curve; D012074:Remission Induction; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D059629:Signal-To-Noise Ratio; D012907:Smoking; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Acute myeloid leukemia (AML); diffusion-weighted imaging (DWI); intravoxel incoherent motion (IVIM); marrow; prognosis