title: Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes.
abstract: Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting.
authors.affiliation: Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Melbourne, Australia.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Cancer & Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Australia.
authors.forename: Cameron N
authors.initials: CN
authors.lastname: Johnstone
authors.affiliation: Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Melbourne, Australia. Electronic address: astew@unimelb.edu.au.
authors.forename: Alastair G
authors.initials: AG
authors.lastname: Stewart
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D017305:Annexin A1 / Q000032:analysis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D001940:Breast / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000276:immunology / Q000473:pathology; D059016:Tumor Microenvironment
chemical_list: D017305:Annexin A1
keywords: Annexin A1; Breast cancer; Cancer immunoediting; Tumour microenvironment; Tumour stroma