title: Schizotypal and affective traits in the offspring of antenatally depressed mothers - Relationship to family history of psychosis in the Northern Finland 1966 Birth Cohort.
abstract: Maternal depression is relatively common during pregnancy. However, follow-ups of the adult offspring of antenatally depressed mothers are scarce. Previously we found the risk of schizophrenia to be higher in the adult offspring with antenatally depressed mothers and parents with psychosis than in subjects with only one or neither of these risk factors. The aim was to study whether the risk of schizotypal or affective traits differ among adult offspring with antenatally depressed mothers with or without a parental history of psychosis when compared with offspring without antenatally depressed mothers and without parental psychosis.
  
  
  
  In the general population-based Northern Finland 1966 Birth Cohort (NFBC 1966), the mothers of the cohort members were asked at mid-gestation whether they felt depressed. Parental psychosis (Familial Risk, FR) was detected using the Finnish Care Register for Health Care. In the 31-year field study, seven psychometric questionnaires surveyed schizotypal and affective traits in the offspring. The final sample included 4928 individuals (2203 males).
  
  
  
  There were no statistically significant differences in mean scores on the schizotypal and affective scales between offspring with and without antenatally depressed mothers, or between subjects with and without parental psychosis. The scores were not highest in the subjects with both maternal antenatal depressed mood and FR.
  
  
  
  Surprisingly, maternal depressed mood during pregnancy was unlikely to increase the risk of schizotypy or affective traits in adult offspring, and not even with parental psychosis (FR) in this general population-based birth cohort with about 5000 subjects.
authors.affiliation: Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland. Electronic address: tiinarie@mail.student.oulu.fi.
authors.forename: T
authors.initials: T
authors.lastname: Taka-Eilola Née Riekki
authors.affiliation: Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland; Center for Life Course Health Research, University of Oulu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Miettunen
authors.affiliation: Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland; Department of Psychiatry, Oulu University Hospital, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland; Department of Psychiatry, Länsi-Pohja Healthcare District, Finland; Department of Psychiatry, the Middle Ostrobothnia Central Hospital, Soite, Finland; Mental Health Services, Joint Municipal Authority of Wellbeing in Raahe District, Finland; Mental Health Services, Basic Health Care District of Kallio and Oulaskangas-Visala Hospital, the Northern Ostrobothnia Hospital District, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Mäki
mesh_terms: D000328:Adult; D032721:Adult Children / Q000523:psychology* / Q000706:statistics & numerical data; D016241:Child of Impaired Parents / Q000523:psychology* / Q000706:statistics & numerical data; D015331:Cohort Studies; D003863:Depression / Q000523:psychology; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D009035:Mothers / Q000523:psychology* / Q000706:statistics & numerical data; D011247:Pregnancy; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology* / Q000209:etiology; D012565:Schizophrenic Psychology; D011795:Surveys and Questionnaires
keywords: Follow-up; Maternal depression; NFBC 1966; Parental psychosis; Pregnancy; Schizotypy