title: Application of CASIA SS-1000 Optical Coherence Tomography Tear Meniscus Imaging in Testing the Efficacy of New Strip Meniscometry in Dry Eye Diagnosis.
abstract: OBJECTIVE
  To investigate the applicability of CASIA SS-1000 anterior-segment optical coherence tomography (AS-OCT) imaging parameters in testing the efficacy of the new strip meniscometry (SM) namely "Strip Meniscometry Tube" (SMTube) in the diagnosis of dry eyes.
  
  
  METHODS
  Forty-three eyes of 22 patients (4 men and 18 women) with definite dry eye disease (DED) and 49 eyes of 28 normal controls (6 men and 22 women) were studied. All subjects underwent symptom questionnaires, SMTube, the Schirmer-1 test, tear film break-up time measurement, vital staining examinations, as well as tear meniscus height (TMH) and TM area (TMA) measurements using an AS-OCT system. We evaluated the cutoff values for the diagnosis of DED, looked into the correlations between TMH, TMA, and SMTube scores and checked the sensitivity and specificity of these parameters in the diagnosis of DED.
  
  
  RESULTS
  The mean values of TMH, TMA, and SMTube scores in the patient group were 0.138±0.102 mm, 0.013±0.015 mm and 1.4±2.3 mm, whereas those for the control group were 0.27±0.10 mm, 0.033±0.025 mm and 5.8±2.8 mm, respectively. The differences between both groups were significant (P<0.001). The cutoff values of TMH, TMA, and SMTube for DED were 0.197 mm, 0.020 mm and 3.8 mm, respectively. SMTube had significant correlations with TMH (r=0.82, P<0.001) and TMA (r=0.86, P<0.001).
  
  
  CONCLUSIONS
  The SMTube was useful in DED diagnosis, the validity of which could be effectively evaluated by the CASIA SS-1000 AS-OCT TM parameters.
authors.affiliation: Department of Ophthalmology (M.S., T.S.), Fukushima Medical University, Fukushima, Japan; Department of Ophthalmology (M.S., M.D., J.S.), Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan; Department of Ophthalmology (M.D.), Keio University School of Medicine, Tokyo, Japan; and Research Unit Echo Electricity Co., Ltd (K.M.), Tokyo, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Shinzawa
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Keiichi
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Jun
authors.initials: J
authors.lastname: Shimazaki
authors.forename: Tetsuju
authors.initials: T
authors.lastname: Sekiryu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015352:Dry Eye Syndromes / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013666:Tears / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*