title: The Guanidine Riboswitch-A Poor Orphan No Longer.
abstract: Riboswitches are widespread in the bacterial kingdom, where they regulate gene expression in response to different small molecules and ions. However, some remain orphans with no known endogenous ligand. Three recently published papers (Battaglia et al., 2017; Nelson et al., 2017; and Reiss et al., 2017) de-orphanize a widespread ykkC element, showing that it responds to guanidine and elaborating on how that response is mediated.
authors.affiliation: CRUK Nucleic Acid Structure Research Group, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address: d.m.j.lilley@dundee.ac.uk.
authors.forename: David M J
authors.initials: DMJ
authors.lastname: Lilley
mesh_terms: D001419:Bacteria / Q000235:genetics; D054540:Child, Orphaned; D019791:Guanidine; D006146:Guanidines; D009690:Nucleic Acid Conformation; D058928:Riboswitch
chemical_list: D006146:Guanidines; D058928:Riboswitch; D019791:Guanidine