title: Re-evaluating the Incidence of Idiopathic Intracranial Hypertension in an Era of Increasing Obesity.
abstract: To re-evaluate the population-based incidence of idiopathic intracranial hypertension (IIH) and to determine if it mirrors the rise in obesity.
  
  
  
  Retrospective, population-based cohort.
  
  
  
  All residents of Olmsted County, Minnesota, diagnosed with IIH between January 1, 1990, and December 31, 2014.
  
  
  
  All cases of IIH were identified using the Rochester Epidemiology Project, which is a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota, residents. All medical records were reviewed to confirm a diagnosis of IIH. The incidence rates of IIH were compared against the incidence of obesity in Minnesota over the same period.
  
  
  
  Incidence of IIH, lumbar puncture opening pressures, and body mass index.
  
  
  
  There were 63 new cases of IIH, yielding an overall age- and gender-adjusted annual incidence of 1.8 per 100 000 (95% confidence interval, 1.3-2.2) between 1990 and 2014. It increased from 1.0 per 100 000 (1990-2001) to 2.4 per 100 000 (2002-2014; P = 0.007). The incidence of IIH was 3.3 per 100 000 in women and 0.3 per 100 000 in men (P ≤ 0.001). In obese women 15 to 44 years of age, the incidence was 22.0 per 100 000 compared with 6.8 per 100 000 among all women in the same age group. A strong correlation was observed between IIH incidence rates and obesity rates in Minnesota (R2= 0.70, P = 0.008).
  
  
  
  The incidence of IIH has increased since 1990, which is highly correlated with the rise in obesity during the same period.
authors.affiliation: College of Medicine, Mayo Clinic, Jacksonville, Florida; Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Khin P
authors.initials: KP
authors.lastname: Kilgore
authors.affiliation: Department of Neuro-Ophthalmology, University of Minnesota, Minneapolis, Minnesota.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Leavitt
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Bahram
authors.initials: B
authors.lastname: Mokri
authors.affiliation: Department of Health Sciences Research/Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida.
authors.forename: David O
authors.initials: DO
authors.lastname: Hodge
authors.affiliation: Department of Health Sciences Research/Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Frank
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida. Electronic address: chen.john@mayo.edu.
authors.forename: John J
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D011559:Pseudotumor Cerebri / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D055815:Young Adult