title: Protective effects of short-term dietary restriction in surgical stress and chemotherapy.
abstract: Reduced caloric intake including fasting, as well as the dietary composition or the timing of food intake, impact longevity, likely through a modification in the onset or the severity of chronic aging-related diseases such as cancer. As with pre- and post-operative dietary recommendations, evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting. We hypothesize that preventive dietary recommendations can help in the context of both chronic cancer treatment efficacy and the avoidance of development of secondary malignancies, as well as in the context of protection from the acute stress of surgery. In this perspective review, we will discuss the latest findings on the potential role of short-term dietary restriction in cancer treatment and improvement of surgical outcome.
authors.affiliation: Longevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Brandhorst
authors.affiliation: Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115 USA.
authors.forename: Eylul
authors.initials: E
authors.lastname: Harputlugil
authors.affiliation: Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115 USA. Electronic address: jmitchel@hsph.harvard.edu.
authors.forename: James R
authors.initials: JR
authors.lastname: Mitchell
authors.affiliation: Longevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.
authors.forename: Valter D
authors.initials: VD
authors.lastname: Longo
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D004032:Diet; D002149:Energy Intake; D005215:Fasting / Q000502:physiology*; D006801:Humans; D008136:Longevity; D009369:Neoplasms / Q000517:prevention & control*; D011300:Preoperative Care; D015398:Signal Transduction; D013312:Stress, Physiological
keywords: Calorie restriction; Cancer; Chemotherapy; Dietary restriction; Fasting; Surgery