title: Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
abstract: BACKGROUND
  Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.
  
  
  METHODS
  Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique.
  
  
  RESULTS
  The median of serum levels of IL-1β, IL-8 and RANTES were significantly higher in the exposed patients with acne than those without acne (P = 0.05, 0.03 and 0.001 respectively). There was no significant difference in serum levels of IL-1α, IL-1Ra and IL-6 between the exposed subgroups.
  
  
  CONCLUSIONS
  We found a positive association between serum levels of pro-inflammatory cytokines (IL-1β, IL-8, IL-12 and RANTES) and acne among SM-exposed population.
authors.affiliation: Department of Biology, Faculty of Basic Sciences, Shahid Bahonar, University of Kerman, Kerman, I.R. Iran.
authors.forename: Nayere
authors.initials: N
authors.lastname: Askari
authors.affiliation: Immunoregulation Research Center, Shahed University, Tehran, I.R. Iran.
authors.forename: Tooba
authors.initials: T
authors.lastname: Ghazanfari
authors.affiliation: Immunoregulation Research Center, Shahed University, Tehran, I.R. Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Yaraee
authors.affiliation: Immunoregulation Research Center, Shahed University, Tehran, I.R. Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Vaez Mahdavi
authors.affiliation: Janbazan Medical and Engineering Research Center (JMERC), Tehran, I.R. Iran.
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Soroush
authors.affiliation: Department of Immunology, Tarbiat Moddares University, Tehran, I.R. Iran.
authors.forename: Zuhair
authors.initials: Z
authors.lastname: Mohammad Hassan
authors.affiliation: Department of Dermatology, Tehran University Medical Sciences, Tehran, I.R. Iran.
authors.forename: Zohre
authors.initials: Z
authors.lastname: Khodashenas
authors.affiliation: Immunoregulation Research Center, Shahed University, Tehran, I.R. Iran.
authors.forename: Jalaleddin
authors.initials: J
authors.lastname: Shams
authors.affiliation: Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
authors.forename: Soghrat
authors.initials: S
authors.lastname: Faghihzadeh
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced*; D000328:Adult; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D006801:Humans; D018664:Interleukin-12 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007492:Iran; D008297:Male; D008875:Middle Aged; D009151:Mustard Gas / Q000633:toxicity*
chemical_list: C483024:CCL5 protein, human; C508606:CXCL8 protein, human; D018946:Chemokine CCL5; D016207:Cytokines; C508585:IL1B protein, human; D053583:Interleukin-1beta; D016209:Interleukin-8; D018664:Interleukin-12; D009151:Mustard Gas