title: Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method.
abstract: In this study, the anticancer drug letrozole (LTZ) was formulated using chitosan nanoparticles (CS-NPs) with the crosslinking agent sodium tripolyphosphate (TPP). The nano-formulation was optimized by varying the concentration of drug. The prepared particles were characterized using FTIR, TGA, XRD, SEM, TEM and DLS. From the FTIR results, the appearance of a new peak for CH, CC and CN confirms the formation of LTZ loaded chitosan nanoparticles. TEM images shows that the average particle size was in the range of 60-80nm and 20-40mm air dried and freeze dried samples respectively. Also the prepared formulation had been evaluated in vitro for determining its hemocompatability, biodegradability and serum stability. The preliminary studies supported that the chitosan nanoparticles formulation has biocompatibility and hemocompatible properties and it can act as an effective pharmaceutical excipient for letrozole.
authors.affiliation: Department of Chemistry, D.K.M. College for Women, Vellore, Tamil Nadu, India.
authors.forename: Thandapani
authors.initials: T
authors.lastname: Gomathi
authors.affiliation: Department of Chemistry, D.K.M. College for Women, Vellore, Tamil Nadu, India. Electronic address: drparsu8@gmail.com.
authors.forename: P N
authors.initials: PN
authors.lastname: Sudha
authors.affiliation: Department of Chemistry, Voorhees College, Vellore, Tamil Nadu, India.
authors.forename: J Annie Kamala
authors.initials: JAK
authors.lastname: Florence
authors.affiliation: Marine Bioprocess Research Center and Department of Marine-bio Convergence Science, Pukyong National University, Busan, Republic of Korea.
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Venkatesan
authors.affiliation: Division of Periodontics, Department of PDS, College of Dentistry, Prince Sattam Bin Abdulaziz University, Riyadh, Saudi Arabia.
authors.forename: Sukumaran
authors.initials: S
authors.lastname: Anil
mesh_terms: D001672:Biocompatible Materials; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D004355:Drug Stability; D006801:Humans; D006860:Hydrogen Bonding; D007477:Ions / Q000737:chemistry*; D007700:Kinetics; D000077289:Letrozole; D008422:Materials Testing; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009570:Nitriles / Q000008:administration & dosage / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014230:Triazoles / Q000008:administration & dosage / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D007477:Ions; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D048271:Chitosan
keywords: Chitosan nanoparticles; Hemocompatability; Letrozole; Optimization; Serum stability