title: Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity.
abstract: Helicobacter and Campylobacter species are Gram-negative microaerophilic host-associated heterotrophic bacteria that invade the digestive tract of humans and animals. Campylobacter jejuni is the major worldwide cause of foodborne gastroenteritis in humans, while Helicobacter pylori is ubiquitous in over half of the world's population causing gastric and duodenal ulcers. The colonisation of the gastrointestinal system by Helicobacter and Campylobacter relies on numerous cellular defences to sense the host environment and respond to adverse conditions, including those imposed by the host immunity. An important antimicrobial tool of the mammalian innate immune system is the generation of harmful oxidative and nitrosative stresses to which pathogens are exposed during phagocytosis. This review summarises the regulators, detoxifying enzymes and subversion mechanisms of Helicobacter and Campylobacter that ultimately promote the successful infection of humans.
authors.affiliation: Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada.
authors.forename: Annika
authors.initials: A
authors.lastname: Flint
authors.affiliation: Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Stintzi
authors.affiliation: Instituto de Tecnologia Química e Biológica, NOVA, Av. da República, Oeiras, Portugal.
authors.forename: Lígia M
authors.initials: LM
authors.lastname: Saraiva
mesh_terms: D000818:Animals; D002167:Campylobacter / Q000276:immunology / Q000472:pathogenicity; D002169:Campylobacter Infections / Q000276:immunology / Q000382:microbiology; D016998:Helicobacter / Q000276:immunology / Q000472:pathogenicity; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology; D007113:Immunity, Innate / Q000276:immunology / Q000502:physiology; D008322:Mammals / Q000276:immunology / Q000382:microbiology; D000073039:Nitrosative Stress / Q000276:immunology*; D018384:Oxidative Stress / Q000276:immunology*
keywords: Helicobacter; Campylobacter; pathogen; innate immunity; bacterial defences