title: Core-shell drug carrier from folate conjugated chitosan obtained from prawn shell for targeted doxorubicin delivery.
abstract: A multifunctional drug carrier with dual targeting (magnetic and folate-receptor) and pH sensitive core-shell hybrid nanomaterial has been developed to carry an anticancer drug doxorubicin.Superparamagnetic iron oxide nanoparticles (IONPs) were used as core of the carrier and cross-linked folate conjugated chitosan (FA-CS) was acted as shell in which doxorubicin was physically entrapped. Transmission electron microscopy (TEM) analysis confirmed the average particle size of IONPs and FA-CS coated IONPs 8.2 and 15.4 nm respectively. Magnetic measurement indicated that both the IONPs and FA-CS coated IONPs were superparamagnetic at room temperature with a magnetization value 57.72 and 37.44 emu/g respectively. At pH 5.8 (malignant tissue) showed a burst release of 30.05% of the doxorubicin in the first 4 h followed by a sustained release of 88.26% of drug over 72 h. From these results it is expected that doxorubicin loaded nanoparticles can be a promising drug carrier for the treatment of solid tumors with the ability to reduce toxic side effects of drugs by selective targeting and sustained release.
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka, 1000, Bangladesh.
authors.forename: Md Sazedul
authors.initials: MS
authors.lastname: Islam
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka, 1000, Bangladesh. papiahq@yahoo.com.
authors.forename: Papia
authors.initials: P
authors.lastname: Haque
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka, 1000, Bangladesh.
authors.forename: Taslim U
authors.initials: TU
authors.lastname: Rashid
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka, 1000, Bangladesh.
authors.forename: M Nuruzzaman
authors.initials: MN
authors.lastname: Khan
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka, 1000, Bangladesh.
authors.forename: Abul K
authors.initials: AK
authors.lastname: Mallik
authors.affiliation: Material Science Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission, Dhaka, 1000, Bangladesh.
authors.forename: M Nazrul I
authors.initials: MN
authors.lastname: Khan
authors.affiliation: Designated Reference Institute for Chemical Measurements (DRICM), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Kudrat-e-Khoda Road, Dhaka, 1205, Bangladesh.
authors.forename: Mala
authors.initials: M
authors.lastname: Khan
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka, 1000, Bangladesh. mizanur.rahman@du.ac.bd.
authors.forename: Mohammed Mizanur
authors.identifier: http://orcid.org/0000-0001-7576-9269
authors.initials: MM
authors.lastname: Rahman
mesh_terms: D060105:Animal Shells / Q000737:chemistry*; D000818:Animals; D002469:Cell Separation; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D005290:Ferric Compounds / Q000737:chemistry; D005434:Flow Cytometry; D005492:Folic Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D033561:Penaeidae; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013696:Temperature
chemical_list: D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D004317:Doxorubicin; D048271:Chitosan; D005492:Folic Acid