title: [Condition and consequences of zinc metabolic disorder in patients with neurosurgical pathology requiring intensive care].
abstract: BACKGROUND
  diseases that require neurosurgical intervention for many years constitute the major cause of disability and death in the world. These patients develop the disorder of zinc supply which is a universal bioregulator. The aim of the research is the assessment of zinc metabolism and effects of its disorder in patients with neurosurgical disorders that require intensive care.
  
  
  METHODS
  observational analytical retrospective research ( « Case control study » type) of zinc exchange status in 60 patients was conducted. Study group included 40 patients of neurosurgical profile who needed intensive care. Control group consisted of 20 conventionally healthy volunteers. Presence of clinical and laboratory signs of zinc deficiency, presence or absence of gastrointestinal failure, level of consciousness, need for mechanical ventilation, and severity of patient's condition were assessed. Statistical analysis of the results was performed using the methods of descriptive statistics, nonparametric comparison of two groups in terms of qualitative and quantitative indicators, establishing correlation relationships.
  
  
  CONCLUSIONS
  in neurosurgical patients requiring intensive care, on the third day of treatment reduction in plasma zinc was observed, causing the clinical signs of zinc deficiency, even without achieving the minimum diagnostically significant threshold of its content in blood of 13 mcM/l. Zinc deficiency contributes to gastrointestinal, cerebral and immune insufficiency, increases the need for artificial lung ventilation and aggravates the severity of patient's condition. At the same time, high mortality of neurosurgical patients requiring intensive care is not directly related to the level of zinc in the blood plasma.
authors.affiliation: Higher State Educational Institution of Ukraine" Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: Petro
authors.initials: P
authors.lastname: Teriv
authors.affiliation: Higher State Educational Institution of Ukraine" Ukrainian Medical Stomatological Academy", Poltava, Ukraine, e-mail: Shkurupiy@list.ru.
authors.forename: Dmytro
authors.initials: D
authors.lastname: Shkurupii
authors.affiliation: Higher State Educational Institution of Ukraine" Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: Yuliia
authors.initials: Y
authors.lastname: Hryshko
mesh_terms: D000328:Adult; D002493:Central Nervous System Diseases / Q000150:complications* / Q000601:surgery; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000209:etiology* / Q000473:pathology; D019635:Neurosurgical Procedures; D012189:Retrospective Studies; D055815:Young Adult; D015032:Zinc / Q000172:deficiency*
chemical_list: D015032:Zinc
keywords:  intensive care ;  neurosurgery; zinc