title: The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients.
abstract: Patients diagnosed with schizophrenia often present with low-level sensory deficits. It is an open question whether there is a functional link between these deficits and the pathophysiology of the disease, e.g. oxidative stress and glutathione (GSH) metabolism dysregulation. Auditory evoked potentials (AEPs) were recorded from 21 psychosis disorder patients and 30 healthy controls performing an active, auditory oddball task. AEPs to standard sounds were analyzed within an electrical neuroimaging framework. A peripheral measure of participants' redox balance, the ratio of glutathione peroxidase and glutathione reductase activities (GPx/GR), was correlated with the AEP data. Patients displayed significantly decreased AEPs over the time window of the P50/N100 complex resulting from significantly weaker responses in the left temporo-parietal lobe. The GPx/GR ratio significantly correlated with patients' brain activity during the time window of the P50/N100 in the medial frontal lobe. We show for the first time a direct coupling between electrophysiological indices of AEPs and peripheral redox dysregulation in psychosis patients. This coupling is limited to stages of auditory processing that are impaired relative to healthy controls and suggests a link between biochemical and sensory dysfunction. The data highlight the potential of low-level sensory processing as a trait-marker of psychosis.
authors.affiliation: Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
authors.forename: Eveline
authors.initials: E
authors.lastname: Geiser
authors.affiliation: Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
authors.forename: Chrysa
authors.initials: C
authors.lastname: Retsa
authors.affiliation: Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; The EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Knebel
authors.affiliation: Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
authors.forename: Carina
authors.initials: C
authors.lastname: Ferrari
authors.affiliation: Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
authors.forename: Raoul
authors.initials: R
authors.lastname: Jenni
authors.affiliation: Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
authors.forename: Margot
authors.initials: M
authors.lastname: Fournier
authors.affiliation: Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Psychiatric Liaison Service, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
authors.forename: Luis
authors.initials: L
authors.lastname: Alameda
authors.affiliation: Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
authors.forename: Philipp S
authors.initials: PS
authors.lastname: Baumann
authors.affiliation: Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Clarke
authors.affiliation: Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Conus
authors.affiliation: Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
authors.forename: Kim Q
authors.initials: KQ
authors.lastname: Do
authors.affiliation: Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; The EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Psychiatric Liaison Service, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA. Electronic address: micah.murray@chuv.ch.
authors.forename: Micah M
authors.initials: MM
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006311:Hearing Disorders / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D012569:Schizotypal Personality Disorder / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase
keywords: Auditory; Event-related potential (ERP); Glutathione (GSH); Oxidative stress; Psychosis; Schizophrenia