title: Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development.
abstract: Aberrant miRNA expression is well recognized as a cancer hallmark, nevertheless miRNA function and expression does not always correlate in patients tissues and cell lines studies. In addition to this issue, miRNA strand usage conduces to increased cell signaling pathways modulation diversifying cellular processes regulation. In cervical cancer, 20 miRNA families are involved in carcinogenesis induction and development to this moment. These families have 5p and 3p strands with different nucleotide (nt) chain sizes. In general, mature 5p strands are larger: two miRNAs of 24 nt, 24 miRNAs of 23 nt, 35 miRNAs of 22 nt and three miRNAs of 21 nt. On the other hand, the 3p strands lengths observed are: seven miRNAs of 23 nt, 50 miRNAs of 22 nt, six miRNAs of 21 nt and four miRNAs of 20 nt. Based on the analysis of the 20 miRNA families associated with cervical cancer, 67 3p strands and 65 5p strands are selected suggesting selectivity and specificity mechanisms regulating cell processes like proliferation, apoptosis, migration, invasion, metabolism and Warburg effect. The insight reviewed here could be used in the miRNA based therapy, diagnosis and prognosis approaches.
authors.affiliation: Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Zacatecas 98066, Mexico. agranadosjudith@gmail.com.|Doctorado en Ciencias Básicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Campus II, Zacatecas 98066, Mexico. agranadosjudith@gmail.com.
authors.forename: Angelica Judith
authors.initials: AJ
authors.lastname: Granados-López
authors.affiliation: Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Zacatecas 98066, Mexico. jocaru2012@gmail.com.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ruiz-Carrillo
authors.affiliation: School of Life Sciences, Gibbert Hill Campus, University of Warwick, Coventry CV47AL, UK. L.Servin-Gonzalez@warwick.ac.uk.
authors.forename: Luis Steven
authors.initials: LS
authors.lastname: Servín-González
authors.affiliation: Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Zacatecas 98066, Mexico. joseluis_mtzrdz_qfb@hotmail.com.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Martínez-Rodríguez
authors.affiliation: Doctorado en Ciencias Básicas en la Especialidad en Farmacología Médica y Molecular de la Unidad Académica de Medicina Humana y Ciencias de la Salud de la Universidad Autónoma de Zacateacas, Campus Siglo XXI, Kilómetro 6, Ejido la Escondida, Zacatecas CP 98160, Mexico. c_reyes13@yahoo.com.mx.
authors.forename: Claudia Araceli
authors.initials: CA
authors.lastname: Reyes-Estrada
authors.affiliation: Doctorado en Ciencias Básicas en la Especialidad en Farmacología Médica y Molecular de la Unidad Académica de Medicina Humana y Ciencias de la Salud de la Universidad Autónoma de Zacateacas, Campus Siglo XXI, Kilómetro 6, Ejido la Escondida, Zacatecas CP 98160, Mexico. rosalindagh@hotmail.com.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Gutiérrez-Hernández
authors.affiliation: Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Zacatecas 98066, Mexico. jalopez@uaz.edu.mx.|Doctorado en Ciencias Básicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Campus II, Zacatecas 98066, Mexico. jalopez@uaz.edu.mx.
authors.forename: Jesús Adrián
authors.initials: JA
authors.lastname: López
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics*; D005810:Multigene Family; D009857:Oncogenes; D034622:RNA Interference; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: cervical cancer; miRNA families; strand 3p; strand 5p