title: Catalyst free synthesis of α-fluoro-β-hydroxy ketones/α-fluoro-ynols via electrophilic fluorination of tertiary propargyl alcohols using Selectfluor™ (F-TEDA-BF4).
abstract: A facile method for the synthesis of α-fluoro-β-hydroxy ketones/α-fluoro-ynols from tertiary propargyl alcohols under electrophilic fluorination conditions using F-TEDA-BF4has been presented. The products bear pharmaceutically important α-fluoro ketone, gem-diaryl and fluorohydrin moieties in the same molecule. Interestingly, this catalyst free protocol results in monofluorination.
authors.affiliation: School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad 500046, India. bala@uohyd.ac.in.
authors.forename: Naganaboina
authors.initials: N
authors.lastname: Naveen
authors.affiliation: School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad 500046, India. bala@uohyd.ac.in.
authors.forename: Rengarajan
authors.identifier: http://orcid.org/0000-0002-8373-5736
authors.initials: R
authors.lastname: Balamurugan