title: Theranostic Nanoparticles Loaded with Imaging Probes and Rubrocurcumin for Combined Cancer Therapy by Folate Receptor Targeting.
abstract: The combination of different therapeutic modalities is a promising option to combat the recurrence of tumors. In this study, polylactic and polyglycolic acid nanoparticles were used for the simultaneous delivery of a boron-curcumin complex (RbCur) and an amphiphilic gadolinium complex into tumor cells with the aim of performing boron and gadolinium neutron capture therapy (NCT) in conjunction with the additional antiproliferative effects of curcumin. Furthermore, the use of Gd complexes allows magnetic resonance imaging (MRI) assessment of the amount of B and Gd internalized by tumor cells. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were targeted to ovarian cancer (IGROV-1) cells through folate receptors, by including in the formulation a PEGylated phospholipid functionalized with the folate moiety. NCT was performed on IGROV-1 cells internalizing 6.4 and 78.6 μg g-1of10B and157Gd, respectively. The synergic action of neutron treatment and curcumin cytotoxicity was shown to result in a significant therapeutic improvement.
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, 10126, Torino, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Alberti
authors.affiliation: Department of Physics, University of Pavia, via Bassi 6, 27100, Pavia, Italy.|Nuclear Physics National Institute (INFN), University of Pavia, via Bassi 6, 27100, Pavia, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Protti
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, 10126, Torino, Italy.
authors.forename: Morgane
authors.initials: M
authors.lastname: Franck
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, 10126, Torino, Italy.
authors.forename: Rachele
authors.initials: R
authors.lastname: Stefania
authors.affiliation: Department of Physics, University of Pavia, via Bassi 6, 27100, Pavia, Italy.|Nuclear Physics National Institute (INFN), University of Pavia, via Bassi 6, 27100, Pavia, Italy.
authors.forename: Silva
authors.initials: S
authors.lastname: Bortolussi
authors.affiliation: Department of Physics, University of Pavia, via Bassi 6, 27100, Pavia, Italy.|Nuclear Physics National Institute (INFN), University of Pavia, via Bassi 6, 27100, Pavia, Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Altieri
authors.affiliation: Department of Chemistry, University of Torino, via P. Giuria 7, 10125, Torino, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Deagostino
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, 10126, Torino, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, 10126, Torino, Italy.
authors.forename: Simonetta
authors.identifier: 0000-0003-2998-5424
authors.initials: S
authors.lastname: Geninatti Crich
mesh_terms: D016475:3T3 Cells; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D058973:Folate Receptors, GPI-Anchored / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005492:Folic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D017247:Neutron Capture Therapy; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D000068936:Theranostic Nanomedicine
chemical_list: D056831:Coordination Complexes; D004337:Drug Carriers; D058973:Folate Receptors, GPI-Anchored; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005492:Folic Acid; D005682:Gadolinium; D003474:Curcumin
keywords: boron neutron capture therapy; curcumin; gadolinium; magnetic resonance imaging; oncology; poly(lactic-co-glycolic acid)