title: The effect of 18F-FDG-PET image reconstruction algorithms on the expression of characteristic metabolic brain network in Parkinson's disease.
abstract: OBJECTIVE
  To evaluate the reproducibility of the expression of Parkinson's Disease Related Pattern (PDRP) across multiple sets of 18F-FDG-PET brain images reconstructed with different reconstruction algorithms.
  
  
  METHODS
  18F-FDG-PET brain imaging was performed in two independent cohorts of Parkinson's disease (PD) patients and normal controls (NC). Slovenian cohort (20 PD patients, 20 NC) was scanned with Siemens Biograph mCT camera and reconstructed using FBP, FBP+TOF, OSEM, OSEM+TOF, OSEM+PSF and OSEM+PSF+TOF. American Cohort (20 PD patients, 7 NC) was scanned with GE Advance camera and reconstructed using 3DRP, FORE-FBP and FORE-Iterative. Expressions of two previously-validated PDRP patterns (PDRP-Slovenia and PDRP-USA) were calculated. We compared the ability of PDRP to discriminate PD patients from NC, differences and correlation between the corresponding subject scores and ROC analysis results across the different reconstruction algorithms.
  
  
  RESULTS
  The expression of PDRP-Slovenia and PDRP-USA networks was significantly elevated in PD patients compared to NC (p<0.0001), regardless of reconstruction algorithms. PDRP expression strongly correlated between all studied algorithms and the reference algorithm (r⩾0.993, p<0.0001). Average differences in the PDRP expression among different algorithms varied within 0.73 and 0.08 of the reference value for PDRP-Slovenia and PDRP-USA, respectively. ROC analysis confirmed high similarity in sensitivity, specificity and AUC among all studied reconstruction algorithms.
  
  
  CONCLUSIONS
  These results show that the expression of PDRP is reproducible across a variety of reconstruction algorithms of 18F-FDG-PET brain images. PDRP is capable of providing a robust metabolic biomarker of PD for multicenter 18F-FDG-PET images acquired in the context of differential diagnosis or clinical trials.
authors.affiliation: Department of Nuclear Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia. Electronic address: petra.tomse@kclj.si.
authors.forename: Petra
authors.initials: P
authors.lastname: Tomše
authors.affiliation: Department of Nuclear Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia. Electronic address: luka.jensterle@kclj.si.
authors.forename: Luka
authors.initials: L
authors.lastname: Jensterle
authors.affiliation: Department of Nuclear Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia. Electronic address: sebastjan.rep@kclj.si.
authors.forename: Sebastijan
authors.initials: S
authors.lastname: Rep
authors.affiliation: Department of Nuclear Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia. Electronic address: marko.grmek@kclj.si.
authors.forename: Marko
authors.initials: M
authors.lastname: Grmek
authors.affiliation: Department of Nuclear Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia. Electronic address: katja.zaletel@kclj.si.
authors.forename: Katja
authors.initials: K
authors.lastname: Zaletel
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA. Electronic address: deidelbe@northwell.edu.
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA. Electronic address: vdhawan@northwell.edu.
authors.forename: Vijay
authors.initials: V
authors.lastname: Dhawan
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA. Electronic address: yma@northwell.edu.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Neurology, University Medical Centre Ljubljana, Zaloška cesta 2, 1000 Ljubljana, Slovenia; Department of Nuclear Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia. Electronic address: maja.trost@kclj.si.
authors.forename: Maja
authors.initials: M
authors.lastname: Trošt
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography; D015203:Reproducibility of Results
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: FDG-PET; Parkinson’s disease; Reconstruction algorithms; Specific metabolic brain networks