title: Uterine artery Doppler pulsatility index at 11-38 weeks in ICSI pregnancies with egg donation.
abstract: BACKGROUND
  Uterine artery Doppler pulsatility index (UtA-PI) may be different in pregnancies with egg donation (ICSI-ED) as compared to conceptions with autologous intra-cytoplasmatic sperm injection (autologous ICSI) and to spontaneous conceptions (SC).
  
  
  METHODS
  One hundred and ninety-four pregnant women with different modes of conception (MC) were prospectively evaluated: 53 ICSI-ED, 36 autologous ICSI and 105 SC. To evaluate the effects of different MC on PI, multivariable linear regression (MLR) models predicting UtA-PI were fitted after adjustment for maternal age, body mass index, race, parity, smoking status and gestational age.
  
  
  RESULTS
  In the first trimester, at MLR, autologous ICSI was not associated with a significantly different UtA-PI [estimate (EST) 0.01; 95% confidence interval (CI) -0.19, 0.2; P=0.9] when compared to SC. Conversely, MC by ICSI-ED was associated with lower first trimester UtA-PI (EST -0.32; CI -0.55, -0.08; P=0.01) when compared to SC. At MLR, MC by autologous ICSI and by ICSI-ED were not associated with significant differences in the second and third trimester UtA-PI when compared to SC.
  
  
  CONCLUSIONS
  ICSI-ED conception presented lower UtA-PI when compared to SC at 11+0-13+6 weeks but not at later assessments. Correction of UtA-PI measurement specifying the origin of oocyte may be useful in first trimester screening.
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Inversetti
authors.affiliation: Department of Obstetrics and Gynecology, Ospedale Luigi Sacco, University of Milano, Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Mandia
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Candiani
authors.affiliation: Department of Obstetrics and Gynecology, Ospedale Luigi Sacco, University of Milano, Milan, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Cetin
authors.affiliation: Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Larcher
authors.affiliation: Department of Obstetrics and Gynecology, Ospedale Luigi Sacco, University of Milano, Milan, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Savasi
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Papaleo
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cavoretto
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy; D011264:Pregnancy Trimesters; D011673:Pulsatile Flow; D020554:Sperm Injections, Intracytoplasmic; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000502:physiology*
keywords: Egg donation (ED); in vitro fertilization (IVF); intra-cytoplasmatic sperm injection (ICSI); pulsatility index; uterine artery Doppler