title: Pharmacogenomics of platinum-based chemotherapy in non-small cell lung cancer: focusing on DNA repair systems.
abstract: Drug therapy for non-small cell lung cancer consists mainly of platinum-based chemotherapy regimens. However, toxicity, drug resistance, and high risk of death have been seen in the clinic, which means there is a need for optimizing the use of medications. Platinum resistance could be mediated by a series of DNA repair pathways, and therefore, these pathways should be taken into account for optimizing drug using. The goal of pharmacogenomics is to elucidate genetic factors, such as DNA repair genes, which might underlie drug efficacy and effectiveness, and to improve therapeutic effects or guide personalized therapy as well. Here, we reviewed the current knowledge of pharmacogenomic data on DNA repair systems and examined whether they could be further translated into the clinic with evidence-based perspectives.
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, 410008, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Institute of Information Security and Big Data, Central South University, Changsha, 410008, People's Republic of China.
authors.forename: Bi-Yun
authors.initials: BY
authors.lastname: Huang
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China. yinjiye@csu.edu.cn.|Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People's Republic of China. yinjiye@csu.edu.cn.
authors.forename: Ji-Ye
authors.initials: JY
authors.lastname: Yin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics*; D004260:DNA Repair / Q000187:drug effects*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide
chemical_list: D009944:Organoplatinum Compounds
keywords: Cisplatin; DNA repair pathway(s); Drug response; Single nucleotide polymorphism(s); Survival