title: The effect of hypericum perforatum on kidney ischemia/reperfusion damage.
abstract: It has been revealed in recent studies that Hypericum Perforatum (HP) is influential on cancer, inflammatory diseases, bacterial and viral diseases, and has neuroprotective and antioxidant properties. In this study, we investigated the effect of HP, which is known to have antioxidant and anti-inflammatory effects, on kidney I/R damage. Male Sprague-Dawley rats were divided into three groups, and each of the groups had eight rats: The Control Group; the Ischemia/Reperfusion (I/R) Group; and the IR + HP Group which was treated with 50 mg/kg of HP. The right kidneys of the rats were removed, and the left kidney developed ischemia during the 45th min, and reperfusion occurred in the following 3rd h. The histopathological findings and also the level of Malondialdehyde (MDA), Glutathione (GSH) and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) enzyme activations in the renal tissues were measured. Blood Urea Nitrogen (BUN), Creatinin (Cre) from serum samples were determined. The levels of BUN, Cre, and kidney tissue MDA increased at a significant level, and the SOD, CAT, and GSH-PX enzyme activity decreased at a significant level in the I/R group, compared with the Control Group (p < 0.05). In the I/R + HP group, the levels of MDA decreased at a significant level compared to the I/R group, while the SOD, CAT, and GSH-PX activity increased (p < 0.05). In histopathological examinations, it was observed that the tubular dilatation and epithelial desquamation regressed in the IR + HP Group when compared with the I/R Group. It has been shown with the histological and biochemical results in this study that HP is protective against acute renal I/R.
authors.affiliation: a Department of Physiology, Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Cakir
authors.affiliation: a Department of Physiology, Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Duzova
authors.affiliation: b Department of Histology and Embryology, Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Işil
authors.initials: I
authors.lastname: Baysal
authors.affiliation: b Department of Histology and Embryology, Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Cemile Ceren
authors.initials: CC
authors.lastname: Gül
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Gülbahar
authors.initials: G
authors.lastname: Kuşcu
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Kutluk
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Hilal
authors.initials: H
authors.lastname: Çakin
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Şifanur
authors.initials: Ş
authors.lastname: Şeker
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Esranur
authors.initials: E
authors.lastname: İlbeği
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Uslu
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Avci
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Demir
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Akinci
authors.affiliation: c Faculty of Medicine , Inonu University , Malatya , Turkey.
authors.forename: Sercan
authors.initials: S
authors.lastname: Atli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005979:Glutathione Peroxidase / Q000032:analysis; D020902:Hypericum / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology*; D007674:Kidney Diseases; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000032:analysis
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D008315:Malondialdehyde; D003404:Creatinine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Kidney; hypericum perforatum; ischemia-reperfusion; oxidative stress; rat