title: The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches.
abstract: Glycosylation is one of the most prevalent post-translational modifications of a protein, with a defining impact on its structure and function. Many of the proteins involved in the innate or adaptive immune response, including cytokines, chemokines, and antimicrobial peptides (AMPs), are glycosylated, contributing to their myriad activities. The current availability of synthetic coupling and glycoengineering technology makes it possible to customise the most beneficial glycan modifications for improved AMP stability, microbicidal potency, pathogen specificity, tissue or cell targeting, and immunomodulation.
authors.affiliation: London School of Hygiene and Tropical Medicine, Keppel Street, London, UK. Electronic address: natalia.bednarska@lshtm.ac.uk.
authors.forename: Natalia G
authors.initials: NG
authors.lastname: Bednarska
authors.affiliation: London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
authors.forename: Brendan W
authors.initials: BW
authors.lastname: Wren
authors.affiliation: London School of Hygiene and Tropical Medicine, Keppel Street, London, UK. Electronic address: sam.willcocks@lshtm.ac.uk.
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Willcocks
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism* / Q000494:pharmacology; D006031:Glycosylation; D006801:Humans; D011499:Protein Processing, Post-Translational
chemical_list: D023181:Antimicrobial Cationic Peptides