title: Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer.
abstract: OBJECTIVE
  To evaluate the relationship between metabolic 18Fluoro-Deoxyglucose-Positron Emission Tomography (18FDG/PET) and morpho-functional parameters derived by Magnetic Resonance Imaging (MRI) in patients with histologically proven laryngeal cancer. To assess the clinical impact of PET/MRI examination on patient's staging and treatment planning.
  
  
  METHODS
  16 patients with histologically proven laryngeal cancer were enrolled and underwent whole body PET/CT followed by a dedicated PET/MRI of the head/neck region. Data were separately evaluated by two blinded groups: metabolic (SUV and MTV), diffusion (ADC) and perfusion (Ktrans, Ve, kepand iAUC) maps were obtained by positioning regions of interest (ROIs). Tumoral local extension assessed on PET/MRI was compared to endoscopic findings.
  
  
  RESULTS
  A good inter-observer agreement was found in anatomical location and local extension of PET/MRI lesions (Cohen's kappa 0.9). PET/CT SUV measures highly correlate with ones derived by PET/MRI (e.g., p=0.96 for measures on VOI). Significant correlations among metabolic, diffusion and perfusion parameters have been detected. PET/MRI had a relevant clinical impact, confirming endoscopic findings (6 cases), helping treatment planning (9 cases), and modifying endoscopic primary staging (1 case).
  
  
  CONCLUSIONS
  PET/MRI is useful for primary staging of laryngeal cancer, allowing simultaneous collection of metabolic and functional data and conditioning the therapeutic strategies.
authors.affiliation: IRCCS SDN, Via E. Gianturco, 113-80143, Naples, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Cavaliere
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy. Electronic address: valeria.romeo@unina.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Romeo
authors.affiliation: IRCCS SDN, Via E. Gianturco, 113-80143, Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Aiello
authors.affiliation: Department of Neuroscience, Reproductive and Odontostomatologic Science, ENT Section, Federico II University, Naples, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mesolella
authors.affiliation: Department of Neuroscience, Reproductive and Odontostomatologic Science, ENT Section, Federico II University, Naples, Italy.
authors.forename: Brigida
authors.initials: B
authors.lastname: Iorio
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Barbuto
authors.affiliation: Department of Neuroscience, Reproductive and Odontostomatologic Science, ENT Section, Federico II University, Naples, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Cantone
authors.affiliation: IRCCS SDN, Via E. Gianturco, 113-80143, Naples, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Nicolai
authors.affiliation: IRCCS SDN, Via E. Gianturco, 113-80143, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Covello
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging*; D007830:Larynx / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D015588:Observer Variation; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Laryngeal cancer; Magnetic resonance imaging; PET/MRI; Positron emission tomography