title: The Relationship of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Gastrointestinal Bleeding in Henoch-Schonlein Purpura.
abstract: OBJECTIVE
  Henoch-Schonlein Purpura (HSP) is the most widespread systemic vasculitis during childhood. Gastrointestinal tract retention and gastrointestinal bleeding are among its major complications. Neutrophil-Lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are indicators related to inflammatory diseases. This study evaluated the relationship between NLR or PLR and gastrointestinal bleeding in HSP.
  
  
  METHODS
  The study consisted of 119 patients and 40 healthy children in the same age group. White Blood Cell (WBC) count, hemoglobin level, platelet count, mean platelet volume (MPV), neutrophil count and lymphocyte count were recorded. The NLR and PLR were calculated based on the results of complete blood count tests performed during the first visit to the hospital.
  
  
  RESULTS
  The average neutrophil count and NLR of the patients with HSP were found to be significantly increased compared to the control group (P = 0.0001). No significant difference was observed between the PLR average of HSP and control groups (P = 0.053). Platelet count average (P = 0.0001) and PLR (P = 0.001) of the patients with gastrointestinal system (GIS) bleeding were found to be statistically significantly increased compared to those who did not have gastrointestinal bleeding. No significant difference was found in the NLR of the patients with and without gastrointestinal bleeding (P = 0.060).
  
  
  CONCLUSIONS
  While the NLR was significantly increased in patients with HSP in this study, the PLR was found to be more significant in patients with gastrointestinal bleeding. Similar to NLR, PLR may also be used as an inflammatory indicator among children with HSP, who have gastrointestinal bleeding.
authors.affiliation: Bagcilar Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
authors.forename: Ozlem Bostan
authors.initials: OB
authors.lastname: Gayret
authors.affiliation: Bagcilar Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Erol
authors.affiliation: Bagcilar Training and Research Hospital, Department of Pediatric Allergy, Istanbul, Turkey.
authors.forename: Hikmet
authors.initials: H
authors.lastname: Tekin Nacaroglu
keywords: Gastrointestinal Bleeding; Henoch-Schonlein Purpura; Neutrophil-Lymphocyte Ratio; Platelet-Lymphocyte Ratio