title: Risk of Posterior Capsule Rupture During Cataract Surgery in Eyes With Previous Intravitreal Injections.
abstract: OBJECTIVE
  To investigate the risk of posterior capsular rupture (PCR) during cataract surgery in eyes with previous intravitreal injection (IVI).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  The Moorfields Patient Administrative System and OpenEyes electronic databases were used to study all cataract surgery procedures undertaken between January 1, 2012 and August 31, 2015 in the Moorfields main and satellite sites. Clinical data were anonymized and extracted, including prior occurrence and number of intravitreal injections. Logistic regression was performed with the Hosmer-Lemeshow test for goodness of fit to generate odds ratios for possible risk factors.
  
  
  RESULTS
  In total, 62 994 cataract surgery procedures were undertaken over the study period, of which 1035 (1.64%) were in eyes with previous intravitreal injection(s). PCR occurred in 650 (1.04%) eyes. After logistic regression, prior intravitreal injection was associated with an increased risk of PCR (P = .037), with an odds ratio of 1.66. The number of prior injections, indication for injections, and service undertaking the surgery were not associated with increased risk of PCR (P > .1).
  
  
  CONCLUSIONS
  Eyes with previous IVI have a higher risk of PCR. This is not affected by number of previous injections, indication for injections, or the specialty undertaking the surgery.
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom. Electronic address: zshalchi@gmail.com.
authors.forename: Zaid
authors.initials: Z
authors.lastname: Shalchi
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom.
authors.forename: Mali
authors.initials: M
authors.lastname: Okada
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom.
authors.forename: Chris
authors.initials: C
authors.lastname: Whiting
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom.
authors.forename: Robin
authors.initials: R
authors.lastname: Hamilton
mesh_terms: D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications; D058449:Intravitreal Injections / Q000009:adverse effects; D007903:Lens Capsule, Crystalline / Q000293:injuries*; D008297:Male; D057851:Posterior Capsular Rupture, Ocular / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids