title: Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: A Comprehensive Review With Analysis of 2 Additional Cases.
abstract: OBJECTIVE
  Primary intraosseous adenoid cystic carcinoma (IACC) of the mandible is poorly understood because of its rarity. This study performed a comprehensive literature review on IACC of the mandible.
  
  
  METHODS
  Forty-five cases of IACC reported in the literature and 2 additional cases in the authors' hospital were reviewed.
  
  
  RESULTS
  IACC of the mandible generally occurred in the fourth to sixth decades, with no meaningful gender predilection. Pain and swelling were the most common clinical manifestations. Radical surgery combined with postsurgical radiotherapy was recommended as the best treatment.
  
  
  CONCLUSIONS
  The diagnosis of IACC should be based on clinical, radiologic, and pathologic examinations. Radical surgery combined with postsurgical radiotherapy seems to be the best treatment. In addition, the histologic subtype of the tumor is an important prognostic factor in patients with IACC.
authors.affiliation: State Key Laboratory of Oral Diseases and Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Sichuan, Chengdu, China.
authors.forename: Hong Ying
authors.initials: HY
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Oral Diseases and Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Sichuan, Chengdu, China.
authors.forename: Yuan Yuan
authors.initials: YY
authors.lastname: Liu
authors.affiliation: Professor and Department Head, Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Sichuan, Chengdu, China. Electronic address: wanghu200108@163.com.
authors.forename: Hu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Sichuan, Chengdu, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D003131:Combined Modality Therapy; D054893:Cone-Beam Computed Tomography; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D008297:Male; D008334:Mandible / Q000473:pathology; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D063168:Mandibular Osteotomy; D008875:Middle Aged; D011862:Radiography, Panoramic; D012086:Reoperation