title: MRI and 18F-FDG-PET/CT in a rare case of early (precursor) B-lymphoblastic leukaemia with bone involvement as initial manifestation.
abstract: A 4-year old girl presenting gait difficulty was referred for spine X-ray and Magnetic Resonance Imaging (MRI). MRI showed several diffuse hypointense signals in sacral and lumbar vertebrae. In order to exclude a possible lymphoproliferative disease a 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) was requested. The PET/CT scan confirmed the MRI findings and demonstrated additional findings in the sternum. Therefore, a bone marrow biopsy was performed and a diagnosis of acute lymphoblastic leukaemia - early B type was made.
authors.affiliation: Positron Emission Tomography Centre IRMET S.p.A., Euromedic Inc., Turin, Italy PET Pediatric AIMN InterGroup, Turin, Italy; Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy;. a.cistaro@irmet.com.
authors.forename: Angelina
authors.initials: A
authors.lastname: Cistaro
authors.forename: Vincenzo
authors.initials: V
authors.lastname: La Delfa
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Di Rosa
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cogoni
authors.forename: Natale
authors.initials: N
authors.lastname: Quartuccio
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D000072078:Positron Emission Tomography Computed Tomography; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG-PET/CT; AIEOP-BFM ALL; acute lymphoblastic leukemia; bone; magnetic resonance imaging; pediatrics