title: The Hotspot for (Global) One Health in Primary Food Production: Aflatoxin M1 in Dairy Products.
abstract: One Health involves the multifaceted environment-animal-human web: nevertheless, the role of toxicological issues has yet to be fully explored in this context. Aflatoxin B1 (AFB1) contamination of feeds is a risk for the health of several farm animals, including fishes; milk is the only food of animal origin where a significant feed-food carry over may occur. The main AFB1-related compound present in milk is the hydroxy-metabolite aflatoxin M1 (AFM1). Besides contamination of raw milk, AFM1 is of concern for the whole dairy chain; AFM1 may also contaminate the milk of several other ruminants used for milk/dairy production. In a One Health perspective, milk represents a sentinel matrix for AFB1 vulnerability of the agro-food system, that is crucial in a phase when food/nutritional security becomes a global issue and climatic changes may affect agricultural productions. In the global setting, food chain exposure to long-term toxicants, such as AFM1, is a growing concern for economically developing countries, whereas global trade and climatic change makes AFM1 an emerging hot issue in economically developed countries as well. We critically review the state of the art on AFM1 risk assessment and risk management using two scenarios as case studies: a European Union country where the health system aims at ensuring a high-level protection of food chain (Italy) and the world's largest (and economically developing) producer of dairy products by volume (India). The case studies are used to provide building blocks for a global One Health framework.
authors.affiliation: Istituto Superiore di Sanità , Rome , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Frazzoli
authors.affiliation: Local Health Unit , Piacenza , Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Gherardi
authors.affiliation: Central Institute for Research on Buffalo , Hisar , India.
authors.forename: Navneet
authors.initials: N
authors.lastname: Saxena
authors.affiliation: Ministero della Salute , Rome , Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Belluzzi
authors.affiliation: Istituto Superiore di Sanità , Rome , Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
keywords: India; Italy; climatic change; food safety; food security; risk assessment; risk management; toxicology