title: Retrospective Study of Pegaspargase, Gemicitabine, Oxaliplatin and Dexamethasone (Peg-GemOD) as a First-Line Therapy for Advanced-Stage Extranodal NK/T Cell Lymphoma.
abstract: This study was conducted to retrospectively investigate the efficacy and safety of pegaspargase, gemicitabine, oxaliplatin and dexamethasone (Peg-GemOD) combination chemotherapy as a first-line therapy for advanced-stage extranodal NK/T cell lymphoma (ENKTL). Eighteen patients with newly diagnosed stage III/IV ENKTL were subjected to 3-6 cycles of Peg-GemOD chemotherapy. After 3 cycles of therapy, the overall response rate was 67 % (12/18) with a complete response rate of 28 % (5/18) and a partial response rate of 39 % (7/18). The median overall survival (OS) and progression-free survival (PFS) time were 10 and 8.5 months respectively. For those responders, the median OS and PFS time were significantly better than those of non-responders (median OS, 15 vs. 10 months;P= 0.001 and median PFS, 15 vs. 7 months;P= 0.001). Furthermore, patients with low plasma EBV-DNA levels after induction chemotherapy had a remarkably longer OS and PFS time. The toxicity of Peg-GemOD regimen was acceptable.
authors.affiliation: Department of Hematology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao Ju Road, Shanghai, 200011 People's Republic of China.
authors.forename: Yi-Yun
authors.initials: YY
authors.lastname: Yao
authors.affiliation: Department of Hematology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao Ju Road, Shanghai, 200011 People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Hematology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao Ju Road, Shanghai, 200011 People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhuang
authors.affiliation: Department of Hematology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao Ju Road, Shanghai, 200011 People's Republic of China.
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Zou
authors.affiliation: Department of Hematology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao Ju Road, Shanghai, 200011 People's Republic of China.
authors.forename: Hong-Ju
authors.initials: HJ
authors.lastname: Dou
authors.affiliation: Department of Hematology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao Ju Road, Shanghai, 200011 People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhi-Zao Ju Road, Shanghai, 200011 People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhu
keywords: Extranodal NK/T cell lymphoma; Gemicitabine; Induction chemotherapy; Oxaliplatin; Pegaspargase; Prognostic factors