title: Long non-coding RNA in glioma: signaling pathways.
abstract: Glioma is regarded as the most prevalent malignant carcinoma of the central nervous system. Thus, the development of new therapeutic strategies targeting glioma is of significant clinical importance. Long non-coding RNAs (lncRNAs) are functional RNA molecules without a protein-coding function and are reportedly involved in the initiation and progression of glioma. Dysregulation of lncRNAs in glioma is due to activation of several signaling pathways, such as the BRD4-HOTAIR-β-catenin/PDCD4, p53-Hif-H19/IGF2 and CRNDE/mTOR pathways. Furthermore, microRNAs (miRNAs) such as miR-675 also interact with lncRNAs in glioma. Thus, exploring the mechanisms by which lncRNA control processes will be instrumental for devising new effective therapies against glioma.
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Jiachao
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guan
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Suinuan
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004734:Energy Metabolism; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D034622:RNA Interference; D062085:RNA, Long Noncoding / Q000235:genetics*; D015398:Signal Transduction; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: glioma; long non-coding RNAs; microRNA