title: A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions.
abstract: A catalyst-free green methodology for the synthesis of pharmacologically important spirooxindole derivatives has been developed by a three-component domino reaction between isatin, various amino compounds, and 1,3-dicarbonyl or 3-phenylisoxazolone compounds in ethyl L-lactate medium at room temperature. This new efficient synthetic method facilitated the formation of a wide range of biologically significant spirooxindole derivatives (including 17 new spirooxindoles) under very mild conditions. The cytotoxic activity of one of the isoxazole-fused spirooxindoles was evaluated in MDA-MB 468 breast cancer cell line. It was found that cell survivability decreases with increasing concentration of the selected compound in MDA-MB 468 breast cancer cells.
authors.affiliation: Department of Chemistry, University of Calcutta, Kolkata, 700009, India.
authors.forename: Nazia
authors.initials: N
authors.lastname: Kausar
authors.affiliation: Department of Chemistry, Aliah University, Action Area IIA/27, New Town, Kolkata, 700156, India.
authors.forename: Abdulla Al
authors.initials: AA
authors.lastname: Masum
authors.affiliation: Department of Chemistry, Aliah University, Action Area IIA/27, New Town, Kolkata, 700156, India.
authors.forename: Md Maidul
authors.initials: MM
authors.lastname: Islam
authors.affiliation: Department of Chemistry, University of Calcutta, Kolkata, 700009, India. ardchem@caluniv.ac.in.
authors.forename: Asish R
authors.initials: AR
authors.lastname: Das
mesh_terms: D060326:Chemistry Techniques, Synthetic; D055772:Green Chemistry Technology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013696:Temperature
chemical_list: D007211:Indoles; D013141:Spiro Compounds
keywords: Catalyst-free; Cytotoxic; Ethyl lactate; Green synthesis; Isoxazole; MCRs; Spirooxindole; Structure–activity relationship