title: Profile of ceritinib in the treatment of ALK+ metastatic non-small-cell lung cancer.
abstract: Lung cancer has become one of the leading causes of death in both men and women in the United States, with approximately 230,000 new cases and 160,000 deaths each year. Approximately 80% of lung cancer patients are diagnosed with non-small-cell lung cancer (NSCLC), a subset of epithelial lung cancers that are generally insensitive to chemotherapy. An estimated 3%-7% of NSCLC patients harbor tumors containing anaplastic lymphoma kinase (ALK) gene rearrangement as an oncogenic driver. Subsequent development of the first-generation tyrosine kinase inhibitor crizotinib demonstrated substantial initialALK+-tumor regression, yet ultimately displayed resistance in treated patients. The recently approved tyrosine kinase inhibitor ceritinib has been shown to be an effective antitumor agent against crizotinib-naïve and -resistantALK+-NSCLC patients. In this review, we will provide an overview of biology and management ofALK+-NSCLC with a special focus on clinical development of ceritinib.
authors.affiliation: Wilmot Cancer Center, University of Rochester, Rochester, NY, USA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Burns
authors.affiliation: Wilmot Cancer Center, University of Rochester, Rochester, NY, USA.
authors.forename: Eric S
authors.initials: ES
authors.lastname: Kim
keywords: anaplastic lymphoma kinase; ceritinib; non-small-cell lung cancer