title: Synthesis and Positive Inotropic Activity of [1,2,4]Triazolo[4,3-a] Quinoxaline Derivatives Bearing Substituted Benzylpiperazine and Benzoylpiperazine Moieties.
abstract: In an attempt to search for more potent positive inotropic agents, two series of [1,2,4]triazolo[4,3-a] quinoxaline derivatives bearing substituted benzylpiperazine and benzoylpiperazine moieties were synthesized and their positive inotropic activities evaluated by measuring left atrial stroke volume in isolated rabbit heart preparations. Several compounds showed favorable activities compared with the standard drug, milrinone. Compound6cwas the most potent agent, with an increased stroke volume of 12.53% ± 0.30% (milrinone: 2.46% ± 0.07%) at 3 × 10-5M. The chronotropic effects of compounds having considerable inotropic effects were also evaluated.
authors.affiliation: Tonghua Normal University , College of Pharmaceutical and Food Science, Tonghua 134002, China. liuxuekunth@126.com.
authors.forename: Xue-Kun
authors.initials: XK
authors.lastname: Liu
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China. xuekunliu@sina.com.
authors.forename: Long-Xu
authors.initials: LX
authors.lastname: Ma
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China. 15981392912@163.com.
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Wei
authors.affiliation: College of Medicine, Yanbian University, Yanji 133000, China. cuixun@ybu.edu.cn.
authors.forename: Xun
authors.initials: X
authors.lastname: Cui
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130000, China. yqwang@126.com.
authors.forename: Shi
authors.initials: S
authors.lastname: Zhan
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China. xmyin@ybu.edu.cn.
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Yin
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China. piaohr@ybu.edu.cn.
authors.forename: Hu-Ri
authors.initials: HR
authors.lastname: Piao
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D020105:Milrinone / Q000494:pharmacology; D015394:Molecular Structure; D009200:Myocardial Contraction / Q000187:drug effects; D010879:Piperazines / Q000737:chemistry*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011817:Rabbits; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D010879:Piperazines; D011810:Quinoxalines; D020105:Milrinone
keywords: [1,2,4]triazolo[4,3-a] quinoxaline; atrium; milrinone; positive inotropic activity; stroke volume