title: Multimodality molecular imaging in cardiac regenerative therapy.
abstract: Stem cell therapy holds great promise for the repair and regeneration of damaged myocardium. Disappointing results from recent large-scale randomized trials using adult stem cells, however, have led some to question the efficacy of this new therapeutic. Because most clinical stem cell trials have not incorporated molecular imaging to track cell fate, it may be premature to abandon this approach. Herein, we will review how multimodality imaging can be incorporated into cardiac regenerative therapy to facilitate the translation of stem cell therapy.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.|Cardiology Section, Department of Medicine, Veterans Affairs, 3801 Miranda Ave, Palo Alto, CA, 94304, USA.
authors.forename: Davis
authors.initials: D
authors.lastname: Vo
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA. pknguyen@stanford.edu.|Cardiology Section, Department of Medicine, Veterans Affairs, 3801 Miranda Ave, Palo Alto, CA, 94304, USA. pknguyen@stanford.edu.|Stanford University, 300 Pasteur Drive, Grant Building, S114, Stanford, CA, 94305-5208, USA. pknguyen@stanford.edu.
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D006801:Humans; D064847:Multimodal Imaging; D017202:Myocardial Ischemia / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000166:cytology*; D000072078:Positron Emission Tomography Computed Tomography; D012038:Regeneration; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D015899:Tomography, Emission-Computed, Single-Photon; D057170:Translational Research, Biomedical
keywords: Diagnostic and prognostic application; Myocardial perfusion imaging: SPECT; PET/CT imaging