title: Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation.
abstract: The aim of this study was to identify potential changes that could occur during histological evaluations of CLAWN miniature swine, with potential consequences for subsequent experiments. The systemic organs from male and female CLAWN miniature swine (16.3-42.3 months old) that had been used in long-term studies of coronary stent implantation were examined histologically. Commonly observed histopathological findings were testicular/epididymal atrophy, cyst-like follicles in the ovaries, hemosiderin deposition in the spleen, lipofuscin deposition in the proximal tubular epithelia and presence of eosinophilic globules in the Bowman's space and the lumen of the proximal tubules in the kidneys, and cellular infiltration in several organs, including the eyelids, respiratory organs, and digestive tract. However, none of these changes were serious enough to indicate a significant impact on research. In conclusion, this study identified CLAWN miniature swine as a suitable animal model for various experiments.
authors.affiliation: Research & Development Center, Terumo Corporation, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Isobe
authors.affiliation: Research & Development Center, Terumo Corporation, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Tasaki
authors.affiliation: Research & Development Center, Terumo Corporation, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Research & Development Center, Terumo Corporation, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
authors.forename: Hisako
authors.initials: H
authors.lastname: Terao
authors.affiliation: Research & Development Center, Terumo Corporation, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Souba
authors.affiliation: Nagano Toxicologic-Pathology Consulting, 467-7 Ojiri, Hadano, Kanagawa 257-0011, Japan.
authors.forename: Kasuke
authors.initials: K
authors.lastname: Nagano
authors.affiliation: Research & Development Center, Terumo Corporation, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Hagiwara
keywords: CLAWN miniature swine; background data; histopathology; minipig