title: Does Aerobic Exercise Increase 24-Hour Ambulatory Blood Pressure Among Workers With High Occupational Physical Activity?-A RCT.
abstract: OBJECTIVE
  High occupational physical activity (OPA) increases cardiovascular risk and aerobic exercise has been recommended for reducing this risk. This paper investigates the effects of an aerobic exercise intervention on 24-hour ambulatory blood pressure (ABP) among cleaners with high OPA.
  
  
  METHODS
  Hundred and sixteen cleaners between 18 and 65 years were randomized. During the 4-month intervention period, the aerobic exercise group (AE) (n = 57) performed worksite aerobic exercise (2 × 30 minutes/week), while the reference group (REF) (n = 59) attended lectures. Between-group differences in 4-month ABP changes were evaluated by intention-to-treat analysis using a repeated-measure 2 × 2 multiadjusted mixed-models design.
  
  
  RESULTS
  Relative to REF, 24-hour ABP significantly increased in AE: systolic 3.6 mm Hg (95% confidence interval (CI) 1.6-5.7) and diastolic 2.3 mm Hg (95% CI 0.9-3.8). Cleaners with high aerobic workload exhibited particularly high 24-hour ABP increases: systolic 6.0 mm Hg (95% CI 2.4-9.6), and diastolic 3.8 mm Hg (95% CI 1.3-6.4).
  
  
  CONCLUSIONS
  Aerobic exercise increased 24-hour ABP among cleaners. This adverse effect raises questions about the safety and intended benefits of aerobic exercise, especially among workers with high OPA and a demanding aerobic workload. http://www.controlled-trials.com/ISRCTN86682076. Unique identifier ISRCTN86682076.
  
  
  BACKGROUND
  Trial Number ISRCTN86682076.
authors.affiliation: National Research Centre for the Working Environment, Copenhagen, Denmark.|Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Mette
authors.initials: M
authors.lastname: Korshøj
authors.affiliation: Department of Environmental Health Sciences, Fielding School of Public Health, Southern California NIOSH Education and Research Center, University of California Los Angeles, Los Angeles, US.|Department of Epidemiology, Fielding School of Public Health, Southern California NIOSH Education and Research Center, University of California Los Angeles, Los Angeles, US.
authors.forename: Niklas
authors.initials: N
authors.lastname: Krause
authors.affiliation: Department of Public Health, Ghent University, Ghent, Belgium.
authors.forename: Els
authors.initials: E
authors.lastname: Clays
authors.affiliation: Department of Sports Science and Clinical Biomechanics, University of Southern, Denmark, Odense, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Søgaard
authors.affiliation: Department of Sports Science and Clinical Biomechanics, University of Southern, Denmark, Odense, Denmark.|Sport and Health Sciences, College of Life and Environmental Sciences, St. Luke's Campus, University of Exeter, Exeter, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Krustrup
authors.affiliation: National Research Centre for the Working Environment, Copenhagen, Denmark.|Department of Sports Science and Clinical Biomechanics, University of Southern, Denmark, Odense, Denmark.
authors.forename: Andreas
authors.initials: A
authors.lastname: Holtermann
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003971:Diastole; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006796:Household Work; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D040242:Risk Reduction Behavior; D013599:Systole; D016526:Workload; D017132:Workplace
keywords: blood pressure; cleaners; hypertension; objective measurements; worksite intervention.