title: Flexible and Highly Biocompatible Nanofiber-Based Electrodes for Neural Surface Interfacing.
abstract: Polyimide (PI)-based electrodes have been widely used as flexible biosensors in implantable device applications for recording biological signals. However, the long-term quality of neural signals obtained from PI-based nerve electrodes tends to decrease due to nerve damage by neural tissue compression, mechanical mismatch, and insufficient fluid exchange between the neural tissue and electrodes. Here, we resolve these problems with a developed PI nanofiber (NF)-based nerve electrode for stable neural signal recording, which can be fabricated via electrospinning and inkjet printing. We demonstrate an NF-based nerve electrode that can be simply fabricated and easily applied due to its high permeability, flexibility, and biocompatibility. Furthermore, the electrode can record stable neural signals for extended periods of time, resulting in decreased mechanical mismatch, neural compression, and contact area. NF-based electrodes with highly flexible and body-fluid-permeable properties could enable future neural interfacing applications.
authors.affiliation: Department of Mechanical and Aerospace Engineering, The George Washington University , Washington, DC 20052, United States.|Department of Dental Materials, School of Dentistry, Kyung Hee University , Seoul 02447, Republic of Korea.
authors.forename: Dong Nyoung
authors.identifier: 0000-0002-7717-7184
authors.initials: DN
authors.lastname: Heo
authors.affiliation: Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University , Seoul 05029, Republic of Korea.
authors.forename: Han-Jun
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Center for BioMicroSystems, Korea Institute of Science and Technology , Seoul 02455, Republic of Korea.
authors.forename: Yi Jae
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Dental Materials, School of Dentistry, Kyung Hee University , Seoul 02447, Republic of Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Heo
authors.affiliation: Department of Dental Materials, School of Dentistry, Kyung Hee University , Seoul 02447, Republic of Korea.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Dental Materials, School of Dentistry, Kyung Hee University , Seoul 02447, Republic of Korea.
authors.forename: Donghyun
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University , Seoul 05029, Republic of Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Do
authors.affiliation: Center for BioMicroSystems, Korea Institute of Science and Technology , Seoul 02455, Republic of Korea.
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Dental Materials, School of Dentistry, Kyung Hee University , Seoul 02447, Republic of Korea.
authors.forename: Il Keun
authors.initials: IK
authors.lastname: Kwon
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D004566:Electrodes; D008297:Male; D057139:Nanofibers / Q000737:chemistry*; D009417:Nerve Tissue / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012117:Resins, Synthetic / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D012117:Resins, Synthetic; C029945:polyimide resin
keywords: electrospun nanofiber; flexible device; inkjet printing; nerve electrode; neural interfacing