title: Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis.
abstract: Background:Lipoma preferred partner (LPP) and T-cell activation Rho GTPase activating protein (TAGAP) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease.Methods:The PubMed, Web of Science and Embase databases were searched (up to October 2016) forLPPrs1464510 andTAGAPrs1738074 polymorphisms.Results:This meta-analysis included the same 7 studies forLPPrs1464510 andTAGAPrs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22-1.30) and 1.17 (95% CI: 1.14-1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects.Conclusions:This meta-analysis provides robust estimates that polymorphisms inLPPandTAGAPgenes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease.
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. cookiehaha@sina.cn.
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. lilyronna@outlook.com.|Department of Preventive Medicine, Zunyi Medical College, Zhuhai Campus, Zhuhai 519041, Guangdong, China. lilyronna@outlook.com.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. m13682215478@163.com.
authors.forename: Zi-Xing
authors.initials: ZX
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. huangcc531@163.com.
authors.forename: Chui-Can
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. chengleezeng@163.com.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Zeng
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. kwstljh@163.com.
authors.forename: Di
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. guo301@aliyun.com.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. yajinghan001@outlook.com.
authors.forename: Ya-Jing
authors.initials: YJ
authors.lastname: Han
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. yestar1989@163.com.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. yestar1989@163.com.
authors.forename: Xing-Guang
authors.initials: XG
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. oumeiling1214@outlook.com.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Ou
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. candy2006520@163.com.
authors.forename: Bao-Huan
authors.initials: BH
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. liuyang199101@126.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China. eddyzeng@jnu.edu.cn.
authors.forename: Eddy Y
authors.initials: EY
authors.lastname: Zeng
authors.affiliation: School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China. guangyangphd@gmail.com.|Department of Parasitology, School of Basic Medical Sciences, Jinan University, Guangzhou 510632, Guangdong, China. guangyangphd@gmail.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China. tjchx@jnu.edu.cn.|School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China. tjchx@jnu.edu.cn.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Jing
mesh_terms: D000483:Alleles; D002446:Celiac Disease / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000235:genetics*; D020690:GTPase-Activating Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D003598:Cytoskeletal Proteins; D020690:GTPase-Activating Proteins; D060588:LIM Domain Proteins; C103594:LPP protein, human; C557017:TAGAP protein, human
keywords: LPP; TAGAP; celiac disease; meta-analysis; polymorphism