title: Recent Advances in Immunity and Hypertension.
abstract: Persistent immune system activation plays an important role in the development of various forms of hypertension. Activation of the innate immune system, inflammation, and subsequent adaptive immune system response causing end-organ injury and dysfunction ultimately leads to hypertension and its associated sequelae including coronary artery disease, heart failure, stroke, and chronic kidney disease. In this review, we will provide updates on the innate and adaptive immune cells involved in hypertension, the current understanding of how the immune system gets activated, and examine the recently discovered mechanisms involved in several forms of experimental hypertension.
authors.affiliation: Department of Medical Physiology, Texas A&M University Health Science Center, College Station, Texas, USA.
authors.forename: Catalina A
authors.initials: CA
authors.lastname: Lopez Gelston
authors.affiliation: Department of Medical Physiology, Texas A&M University Health Science Center, College Station, Texas, USA.
authors.forename: Brett M
authors.initials: BM
authors.lastname: Mitchell
mesh_terms: D056704:Adaptive Immunity; D000804:Angiotensin II; D000818:Animals; D001794:Blood Pressure / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D046110:Hypertension, Pregnancy-Induced / Q000276:immunology / Q000503:physiopathology; D007107:Immune System / Q000276:immunology* / Q000503:physiopathology; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology; D011918:Rats, Inbred SHR; D012307:Risk Factors; D015398:Signal Transduction; D017673:Sodium Chloride, Dietary
chemical_list: D018836:Inflammation Mediators; D017673:Sodium Chloride, Dietary; D000804:Angiotensin II
keywords: blood pressure; hypertension; immunity; inflammation; lymphocytes