title: Relationships Between Spatial Contrast Sensitivity and Parafoveal Cone Density in Normal Subjects and Patients With Retinal Degeneration.
abstract: To investigate the relationship between spatial contrast sensitivity (CS) and parafoveal cone density (PCD).
  
  
  
  Fifteen healthy individuals (mean age: 26.1 years ± 4.5 years) and nine patients with hereditary retinal degeneration (mean age: 31.6 years ± 13.4 years) without media opacities were studied. The CS was measured by CSV-1000 (VectorVision, Greenville, OH). The cone mosaic was photographed with an adaptive optics scanning laser ophthalmoscope (AOSLO) with a 1° × 1° field of view centered on the fovea. The PCD was calculated in an annular area with radii of 0.38° and 0.43°. The CS was converted to the logarithm (logCS), and the area under the logCS function (AULCSF) was determined.
  
  
  
  The AULCSF was significantly and positively correlated with the PCD in the control (R2= 0.522; P = .003) and retinal degeneration (R2= 0.514; P = .03) groups.
  
  
  
  PCD can predict the spatial contrast sensitivity in normal subjects or patients with retinal degeneration without media opacities. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:106-113.].
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hirota
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morimoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kanda
authors.forename: Tibor Karl
authors.initials: TK
authors.lastname: Lohmann
authors.forename: Suguru
authors.initials: S
authors.lastname: Miyagawa
authors.forename: Takao
authors.initials: T
authors.lastname: Endo
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujikado
mesh_terms: D000293:Adolescent; D000328:Adult; D002452:Cell Count; D002648:Child; D015350:Contrast Sensitivity / Q000502:physiology*; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D012162:Retinal Degeneration / Q000175:diagnosis / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000379:methods; D055815:Young Adult