title: Immunotoxin: A new tool for cancer therapy.
abstract: Cancer is one of the main reasons of death in the most countries and in Iran. Immunotherapy quickly became one of the best methods of cancer treatment, along with chemotherapy and radiation. "Immunotoxin Therapy" is a promising way of cancer therapy that is mentioned in this field. Immunotoxins are made from a toxin attaching to an antibody target proteins present on cancer cells. The first-generation immunotoxins were made of a full-length toxin attached to whole monoclonal antibodies. But, these immunotoxins could bind to normal cells. DAB389IL2 was the first immunotoxin approved by the Food and Drug Administration. Current trends and researches are ongoing on finding proteins that in combination with immunotoxins have minimal immunogenicity and the most potency for target cell killing.
authors.affiliation: 1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Allahyari
authors.affiliation: 1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Sahar
authors.initials: S
authors.lastname: Heidari
authors.affiliation: 1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ghamgosha
authors.affiliation: 2 Department of Microbiology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Saffarian
authors.affiliation: 3 Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Amani
mesh_terms: D000818:Animals; D006801:Humans; D007128:Immunoglobulin Fragments / Q000276:immunology; D000922:Immunotoxins / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D007128:Immunoglobulin Fragments; D000922:Immunotoxins
keywords: Toxins; antibody; cancer therapy; immunotoxins