title: Abdominal aortic aneurysm-an independent disease to atherosclerosis?
abstract: Atherosclerosis and abdominal aortic aneurysms (AAAs) are multifactorial and polygenic diseases with known environmental and genetic risk factors that contribute toward disease development. Atherosclerosis represents an important independent risk factor for AAA, as people with AAA often have atherosclerosis. Studies have shown that comorbidity is usually between ~25% and 55%, but it is still not fully known whether this association is causal or a result of common shared risk profiles. Most recent epidemiological, clinical, and biological evidence suggests that the two pathologies are more distinct than traditionally thought. For instance diabetes mellitus, hypercholesterolemia, and obesity are high risk for atherosclerosis development but are not as pronounced in AAA, whereas smoking, gender, and ethnicity are particularly high risk for AAA but less so for atherosclerosis. In addition, genetic and epigenetic studies have identified independent risk loci involved in AAA susceptibility that are not associated with other cardiovascular diseases, and research on important common cardiovascular biomarkers has illustrated discrepancies in those with AAA.
authors.affiliation: Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.. Electronic address: bt96@le.ac.uk.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Toghill
authors.affiliation: Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Saratzis
authors.affiliation: Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Bown
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000150:complications* / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors
keywords: Abdominal aortic aneurysm; Atherosclerosis; Cardiovascular disease; Inflammation; Multifactorial; Polygenic