title: Comparative pharmacokinetics of enrofloxacin in healthy and Aeromonas hydrophila-infected crucian carp (Carassius auratus gibelio).
abstract: The comparative pharmacokinetics of enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP) were investigated in healthy and Aeromonas hydrophila-infected crucian carp after a single oral (p.o.) administration at a dose of 10 mg/kg at 25 °C. The plasma concentrations of ENR and of CIP were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR concentrations by noncompartmental modeling. In healthy fish, the elimination half-life (T1/2λz), maximum plasma concentration (Cmax), time to peak (Tmax), and area under the concentration-time curve (AUC) values were 64.66 h, 3.55 μg/mL, 0.5 h, and 163.04 μg·h/mL, respectively. In infected carp, by contrast, the corresponding values were 73.70 h, 2.66 μg/mL, 0.75 h, and 137.43 μg·h/mL, and the absorption and elimination of ENR were slower following oral administration. Very low levels of CIP were detected, which indicates a low extent of deethylation of ENR in crucian carp.
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.|College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Fan
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Shan
authors.affiliation: Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: G
authors.initials: G
authors.lastname: Zheng
mesh_terms: D016980:Aeromonas hydrophila; D000818:Animals; D019540:Area Under Curve; D000077422:Enrofloxacin; D005393:Fish Diseases / Q000188:drug therapy* / Q000378:metabolism; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D006054:Goldfish / Q000378:metabolism*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*
chemical_list: D024841:Fluoroquinolones; D000077422:Enrofloxacin