title: Lipoprotein-associated phospholipase A2and risk of incident peripheral arterial disease in a multi-ethnic cohort: The Multi-Ethnic Study of Atherosclerosis.
abstract: Prospective studies supporting a relationship between elevated lipoprotein-associated phospholipase A2(Lp-PLA2) and incident peripheral arterial disease (PAD) are limited. We evaluated the association of Lp-PLA2with incident PAD in a multi-ethnic cohort without clinical cardiovascular disease. A total of 4622 participants with measurement of Lp-PLA2mass and Lp-PLA2activity and an ankle-brachial index (ABI) between 0.9 and 1.4 were followed for the development of PAD (median follow-up = 9.3 years), defined as an ABI ⩽0.9 and decline from baseline ⩾0.15. There were 158 incident PAD events during follow-up. In adjusted logistic regression models, each higher standard deviation of both Lp-PLA2activity and mass did not confer an increased risk of developing PAD [odds ratios, (95% confidence intervals)]: 0.92 (0.66-1.27) for Lp-PLA2activity and 1.06 (0.85-1.34) for mass. Additionally, no significant interaction was found according to ethnicity: p=0.43 for Lp-PLA2activity and p=0.55 for Lp-PLA2mass. We found no evidence of an association between Lp-PLA2and incident PAD.
authors.affiliation: 1 Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: Parveen K
authors.initials: PK
authors.lastname: Garg
authors.affiliation: 2 Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Neal W
authors.initials: NW
authors.lastname: Jorgensen
authors.affiliation: 2 Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Robyn L
authors.initials: RL
authors.lastname: McClelland
authors.affiliation: 3 Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Jenny
authors.affiliation: 4 Department of Family Medicine & Public Health, University of California in San Diego, La Jolla, CA, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Criqui
authors.affiliation: 4 Department of Family Medicine & Public Health, University of California in San Diego, La Jolla, CA, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Allison
authors.affiliation: 5 Department of Medicine, Northwestern University, Chicago, IL, USA.|6 Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Greenland
authors.affiliation: 7 Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Rosenson
authors.affiliation: 8 New York Academy of Medicine, New York, NY, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
authors.affiliation: 3 Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA.|9 Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D015994:Incidence; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human
keywords: ankle–brachial index; inflammation; lipoprotein-associated phospholipase A2; peripheral arterial disease (PAD)