title: Malignant tumors associated with ovarian mature teratoma: A single institution experience.
abstract: OBJECTIVE
  The aims of this study are to present demographical features of cases diagnosed with malignant tumor associated with ovarian mature teratoma and to analyze histopathological features and clinical follow up of these tumors.
  
  
  METHODS
  Single-institution retrospective charts were reviewed to identify all cases of ovarian mature teratoma diagnosed from 1998 to 2015. Clinicopathological parameters that were analyzed include age, tumor size, tumor stage, histological type, laterality, IOC diagnosis and whether or not patient has received adjuvant chemotherapy.
  
  
  RESULTS
  A total of 218 ovarian mature teratoma cases were identified during the study period. Of the 218 ovarian mature teratoma specimens, eight (3.7%) exhibited malignant tumors. The average age for cases of malignancy associated with ovarian mature teratoma was 44.6 years. The average size of tumors was 10.36cm. On final pathology, histological types of tumors were as follows: two cases each of squamous cell carcinoma and papillary thyroid carcinoma; one case each of mucinous adenocarcinoma, metastatic adenocarcinoma, sebaceous carcinoma and oligodendroglioma. Only one patient with Stage IIB tumor died of disease. One patient was alive with metastatic disease two months after initial diagnosis. Mean and median follow-up times were 64.1 and 49 months, respectively.
  
  
  CONCLUSIONS
  An ovarian mass that has characteristics of a teratoma in a postmenopausal patient should alert for malignancy -regardless of tumor size. IOC is a valuable tool for the detection of malignancy and should be requested to determine the modality of surgical approach.
authors.affiliation: Department of Pathology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. Electronic address: leventtrabzonlu186@gmail.com.
authors.forename: Levent
authors.initials: L
authors.lastname: Trabzonlu
authors.affiliation: Medical Student, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Guray
authors.initials: G
authors.lastname: Durmaz
authors.affiliation: Department of Pathology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Vural
authors.affiliation: Department of Pathology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Muezzinoglu
authors.affiliation: Department of Gynecology and Obstetrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Corakci
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D002648:Child; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D012189:Retrospective Studies; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology*; D055815:Young Adult
keywords: Associated malignant tumor; Choroid plexus papilloma; Intraoperative consultation; Mature teratoma; Ovary; Postmenopausal women