title: Aggressive cutaneous T-cell lymphomas.
abstract: Cutaneous T cell lymphomas (CTCLs) are heterogeneous, with a prognosis determined in large part by combined clinical, histopathologic, and immunophenotypic features. They are classified under the WHO-EORTC classification of primary cutaneous lymphoma. Whether or not a patient diagnosed with CTCL will experience an aggressive course may not be completely predictable; however, certain subtypes have been proven to be associated with a poor response to therapy and/or short survival. These aggressive subtypes may be diagnosed by certain histologic, immunophenotypic, and clinical features; however, there are benign lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP) that present with biopsy findings that simulate an aggressive lymphoma. Moreover, some of the well-recognized aggressive lymphomas may rarely follow an indolent course, while otherwise indolent lymphomas may act aggressively. This review will focus on the non-mycosis fungoides (MF) aggressive subtypes, as well as potentially aggressive presentations of MF.
authors.affiliation: Ackerman Academy of Dermatopathology, 145 East 32nd, St 10th floor, New York, 10016, NY, USA. Electronic address: jakki22@gmail.com.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Junkins-Hopkins Md
mesh_terms: D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*
keywords: Adult T-cell leukemia/lymphoma; Berti's lymphoma; Cutaneous gamma delta T cell lymphoma