title: Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review.
abstract: Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with aKITexon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.
authors.affiliation: Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Rochigneux
authors.affiliation: Department of Pathology, Institut Paoli-Calmettes, Marseille, France.
authors.forename: Lénaig
authors.initials: L
authors.lastname: Mescam-Mancini
authors.affiliation: Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Perrot
authors.affiliation: Department of Gastroenterology, Institut Paoli-Calmettes, Marseille, France.
authors.forename: Erwan
authors.initials: E
authors.lastname: Bories
authors.affiliation: Department of Radiotherapy, Institut Paoli-Calmettes, Marseille, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Moureau-Zabotto
authors.affiliation: Department of Radiology, Institut Paoli-Calmettes, Marseille, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Sarran
authors.affiliation: Department of Surgery, Institut Paoli-Calmettes, Marseille, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guiramand
authors.affiliation: Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France; Aix-Marseille University, Marseille, France.
authors.forename: François
authors.initials: F
authors.lastname: Bertucci
keywords: Bone metastases; Gastrointestinal stromal tumours; Imatinib; KIT; Tyrosine kinase inhibitors