title: Biomimetic principles to develop blood compatible surfaces.
abstract: Functionalized biomaterial surface patterns capable of resisting nonspecific adsorption while retaining their bioactivity are crucial in the advancement of biomedical technologies, but currently available biomaterials intended for use in whole blood frequently suffer from nonspecific adsorption of proteins and cells, leading to a loss of activity over time. In this review, we address two concepts for the design and modification of blood compatible biomaterial surfaces, zwitterionic modification and surface functionalization with glycans - both of which are inspired by the membrane structure of mammalian cells - and discuss their potential for biomedical applications.
authors.affiliation:  Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Danube University Krems, Krems - Austria.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Semak
authors.affiliation:  Department for Health Sciences and Biomedicine, Danube University Krems, Krems - Austria.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Fischer
authors.affiliation:  Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Danube University Krems, Krems - Austria.| Department for Health Sciences and Biomedicine, Danube University Krems, Krems - Austria.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Weber
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D032701:Biomimetics; D011134:Polysaccharides / Q000378:metabolism; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011134:Polysaccharides