title: Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa.
abstract: Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC50values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Hsin-Yi
authors.identifier: 0000-0001-7666-2420
authors.initials: HY
authors.lastname: Hung
authors.affiliation: Department of Chemistry, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Chi-Wei
authors.initials: CW
authors.lastname: Nian
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University; Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology; and Department of Anesthesiology, Chang Gung Memorial Hospital , Taoyuan 333, Taiwan.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, China Medical University , Taichung 404, Taiwan.
authors.forename: Ju-Chien
authors.initials: JC
authors.lastname: Cheng
authors.affiliation: Department of Pharmacy, College of Pharmacy and Health Care, Tajen University , Pingtung 907, Taiwan.
authors.forename: Daih-Huang
authors.initials: DH
authors.lastname: Kuo
authors.affiliation: Department of Surgery and Anesthesiology and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School , Tainan 701, Taiwan.
authors.forename: E-Jian
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Surgery and Anesthesiology and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School , Tainan 701, Taiwan.
authors.forename: Shih-Huang
authors.initials: SH
authors.lastname: Tai
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.|Department of Pharmacy, College of Pharmacy and Health Care, Tajen University , Pingtung 907, Taiwan.
authors.forename: Tian-Shung
authors.identifier: 0000-0002-2117-0266
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031657:Forsythia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D013624:Taiwan
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D017705:Lignans; D013481:Superoxides; D010196:Pancreatic Elastase