title: Impact of Pulmonary Hypertension on Outcome in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction.
abstract: OBJECTIVE
  The prognostic impact of elevated pulmonary arterial pressure (PAP) remains controversial in aortic stenosis (AS) and few studies focused on patients with preserved left ventricular ejection fraction (LVEF). We aimed to investigate the impact of pulmonary hypertension (PH), invasively derived, on survival in severe AS with preserved LVEF.
  
  
  RESULTS
  Between 2000 and 2010, 749 patients (74 ± 8 years, 57% males) with preserved LVEF and severe AS without other valvular heart disease underwent cardiac catheterization. PH was defined as mean PAP > 25 mmHg. The mean follow-up was 4.6 ± 3.0 years. Overall, 32% (n = 241) of patients had PH. Surgical aortic valve replacement (SAVR) was performed in 91% of patients with 4.5% of 30-day mortality rate, significantly higher in patients with PH than without PH (7.5 vs. 3.5%, p = 0.014). In logistic regression, PH was an independent predictor of increased 30-day mortality (odds-ratio = 2.2, p = 0.04). Overall long-term survival was significantly reduced in patients with PH as compared to those without (10-year: 52 ± 5 vs. 68 ± 3%, p < 0.0001). Likewise, focusing on patients with SAVR showed significant reduced survival in those with PH (10-year: 57 ± 5 vs. 72 ± 3%, p < 0.0001). In multivariate analysis, after adjustment for relevant cofactors, PH was an independent predictor of mortality (hazard ratio = 1.5, p = 0.009). Using quartiles of mean PAP, only patients with most elevated values (Q4: mean PAP: 27-67mmHg) had significantly reduced survival, as compared to other quartiles (all p < 0.0001).
  
  
  CONCLUSIONS
  In patients with severe AS and preserved LVEF, PH is an independent predictor of 30-day and long-term mortality patients. Nevertheless, only severely elevated PAP seems associated with reduced survival.
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.|INSERM 1094, Faculté de médecine de Limoges, 2, rue Marcland, Limoges, 87000, France.
authors.forename: Julien
authors.identifier: http://orcid.org/0000-0001-7598-8234
authors.initials: J
authors.lastname: Magne
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France. dania.mohty@chu-limoges.fr.|INSERM 1094, Faculté de médecine de Limoges, 2, rue Marcland, Limoges, 87000, France. dania.mohty@chu-limoges.fr.
authors.forename: Dania
authors.initials: D
authors.lastname: Mohty
authors.affiliation: Service de Chirurgie Thoracique et Cardiovasculaire, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Piccardo
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Boulogne
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Deltreuil
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Petitalot
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
authors.forename: Najmeddine
authors.initials: N
authors.lastname: Echahidi
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Darodes
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Virot
authors.affiliation: Department of Cardiology, AP-HP, Henri Mondor University Hospital, Creteil, France.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Damy
authors.affiliation: Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.|INSERM 1094, Faculté de médecine de Limoges, 2, rue Marcland, Limoges, 87000, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Aboyans
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000401:mortality / Q000601:surgery; D006328:Cardiac Catheterization / Q000379:methods*; D004452:Echocardiography; D005260:Female; D005602:France / Q000453:epidemiology; D006350:Heart Valve Prosthesis; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D015996:Survival Rate / Q000639:trends; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Aortic valve stenosis; Outcome; Pulmonary arterial pressure