title: Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass: Evidence for Increased Expression of Jejunal Genes Encoding Regenerating Pancreatic Islet-Derived Proteins as a Potential Mechanism.
abstract: Intestinal expression of regenerating pancreatic islet-derived protein-encoding genes (REG) would be enhanced after Roux-en-Y gastric bypass (RYGB) and would affect postoperative type 2 diabetes remission (T2Dr).
  
  
  
  Intestinal biopsy samples were collected from 20 adult obese women with T2D before and 3 months after RYGB. Levels of REG expression and the gene encoding its putative receptor (EXTL3) were assessed by microarray and validated by quantitative RT-PCR. T2Dr was assessed according to ADA criteria 1 year after RYGB.
  
  
  
  After RYGB, only patients with T2Dr had significantly increased REG1α and REG3γ expression in the jejunum, as validated by quantitative RT-PCR.
  
  
  
  Our data provide support for the hypothesis that increased jejunal expression of REG genes after RYGB affects T2Dr, possibly by playing an endocrine function.
authors.affiliation: FMUSP-Department of Gastroenterology, Digestive Surgery Discipline, School of Medicine, University of São Paulo (LIM 35), São Paulo, Brazil. sala.priscila@gmail.com.
authors.forename: Priscila
authors.initials: P
authors.lastname: Sala
authors.affiliation: FMUSP-Department of Gastroenterology, Digestive Surgery Discipline, School of Medicine, University of São Paulo (LIM 35), São Paulo, Brazil.
authors.forename: Raquel Susana
authors.initials: RS
authors.lastname: Torrinhas
authors.affiliation: FMUSP-Department of Gastroenterology, Digestive Surgery Discipline, School of Medicine, University of São Paulo (LIM 35), São Paulo, Brazil.
authors.forename: Danielle Cristina
authors.initials: DC
authors.lastname: Fonseca
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, LA, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Heymsfield
authors.affiliation: University Nove de Julho, São Paulo, Brazil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Giannella-Neto
authors.affiliation: FMUSP-Department of Gastroenterology, Digestive Surgery Discipline, School of Medicine, University of São Paulo (LIM 35), São Paulo, Brazil.
authors.forename: Dan Linetzky
authors.initials: DL
authors.lastname: Waitzberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology; D007515:Islets of Langerhans / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D009767:Obesity, Morbid / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000073718:Pancreatitis-Associated Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D012074:Remission Induction; D055815:Young Adult
chemical_list: D000073718:Pancreatitis-Associated Proteins
keywords: Gene expression; Glycemic control; Regeneration genes; Roux-en-Y gastric bypass; Type 2 diabetes mellitus