title: Dermatologic Reactions to Targeted Therapy: A Focus on Epidermal Growth Factor Receptor Inhibitors and Nursing Care.
abstract: Cancer treatments usually have side effects of bone marrow depression, mucositis, hair loss, and gastrointestinal issues. Rarely do we think of skin side effects until patients have been treated successfully with epidermal growth factor receptor inhibitors (EGFRi). Those reactions include papulopustular rash, hair changes, radiation dermatitis enhancement, pruritus, mucositis, xerosis, fissures, and paronychia. This article discusses the common skin reactions seen when using EGFRi and presents an overview of skin as the largest and important organ of the body, including an overview of skin assessment, pathophysiology of the skin reactions, nursing care involved, and introduction to oncodermatology.
authors.affiliation: Department of Nursing Research, Memorial Sloan Kettering Cancer Center, 205 East 64th Street, Room 251 Concourse Level, New York, NY 10065, USA. Electronic address: bartonbm@mskcc.org.
authors.forename: Margaret
authors.initials: M
authors.lastname: Barton-Burke
authors.affiliation: Department of Dermatology, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Ciccolini
authors.affiliation: Department of Dermatology, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Mekas
authors.affiliation: Department of Nursing Research, Memorial Sloan Kettering Cancer Center, 205 East 64th Street, Room 251 Concourse Level, New York, NY 10065, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Burke
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology* / Q000451:nursing / Q000503:physiopathology; D066246:ErbB Receptors / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D012871:Skin Diseases / Q000209:etiology* / Q000451:nursing / Q000503:physiopathology
chemical_list: D000970:Antineoplastic Agents; D066246:ErbB Receptors
keywords: EGFRi (epidermal growth factor receptor inhibitors); Oncodermatology; Skin reactions