title: A perspective on malignancy in the marrow.
abstract: Malignancies that grow in the bone marrow cause a cascade of devastating consequences and are almost always fatal. For researchers to make significant headway in finding cures and treatments for these tumors and the subsequent devastation of cancer-induced bone disease, novel strategies and creative solutions will have to be considered. Great progress has been made in treating hematologic and sold tumor malignancies that ultimately affect the bone marrow, although it is also obvious that multi-disciplinary teams are required to ultimately win the war on cancers that affect the bone. In this perspective, we review recent advances in the identification of molecular and cellular targets in the bone marrow niche.
authors.affiliation: Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, Maine.|Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine.|Tufts University School of Medicine, Boston, Maine.
authors.forename: Michaela R
authors.identifier: http://orcid.org/0000-0003-2884-6481
authors.initials: MR
authors.lastname: Reagan
authors.affiliation: Department of Biochemistry and the University of Vermont Cancer Center, the University of Vermont Larner College of Medicine, Burlington, Vermont.
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
authors.affiliation: Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, Maine.|Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine.|Tufts University School of Medicine, Boston, Maine.
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Rosen
authors.affiliation: Department of Biochemistry and the University of Vermont Cancer Center, the University of Vermont Larner College of Medicine, Burlington, Vermont.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
mesh_terms: D019046:Bone Marrow Neoplasms; D006801:Humans; D055153:Stem Cell Niche; D023822:Tissue Engineering
keywords: bone marrow niche; bone metastasis; microenvironment; tumor