title: Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta).
abstract: Osteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4-year-old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Radiography revealed fracture and disorganized structure of bone tissue. Histopathological examination revealed malignant neoplasm composed of anaplastic osteoblasts, which invaded the bone marrow and surrounded blood-filled cysts in the epiphysis and diaphysis forming septa. Cytogenetic analysis showed aneuploid cells, supernumerary AgNORs, and a marker fragment. The neoplasm was diagnosed as TO. To our knowledge, the occurrence of TO and its cytogenetic analysis were reported for the first time in non-human primates.
authors.affiliation: Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: B
authors.identifier: 0000-0002-8678-5608
authors.initials: B
authors.lastname: Goldschmidt
authors.affiliation: Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: M I Z
authors.initials: MI
authors.lastname: Calado
authors.affiliation: Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: F C
authors.initials: FC
authors.lastname: Resende
authors.affiliation: Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
authors.forename: R M
authors.initials: RM
authors.lastname: Caldas
authors.affiliation: Divisão de Patologia, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil.
authors.forename: L W
authors.initials: LW
authors.lastname: Pinto
authors.affiliation: Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: C A A
authors.initials: CA
authors.lastname: Lopes
authors.affiliation: Setor de radiologia, Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
authors.forename: F G O
authors.initials: FG
authors.lastname: França
authors.affiliation: Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: B S
authors.initials: BS
authors.lastname: Meireles
authors.affiliation: Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
authors.forename: I V
authors.initials: IV
authors.lastname: Souza
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000662:veterinary*; D020732:Cytogenetic Analysis / Q000662:veterinary; D005260:Female; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000000981:diagnostic imaging*; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000662:veterinary*; D011859:Radiography / Q000662:veterinary; D013684:Telangiectasis / Q000000981:diagnostic imaging / Q000662:veterinary*
keywords: bone cancer; chromosomes; non-human primate; osteosarcoma