title: Role of Rho-specific guanine nucleotide dissociation inhibitor α regulation in cell migration.
abstract: Cell migration is a vital process for many physiological and pathological events, and Rho GTPases have been confirmed as key factors in its regulation. The most studied negative regulator of Rho GTPases, Rho-specific guanine nucleotide dissociation inhibitor α (RhoGDIα), mediates cell migration through altering the overall expression and spatiotemporal activation of Rho GTPases. The RhoGDIα-Rho GTPases dissociation can be mediated by signal pathways targeting RhoGDIα directly. This review summarizes the research about the regulation of RhoGDIα during cell migration, which can be in a Rho GTPases association independent manner. Non-kinase proteins regulation, phosphorylation, SUMOylation and extracellular environmental factors are classified to discuss their direct signal regulations on RhoGDIα, which provide varied signal pathways for selective activation of Rho GTPases in cell migration.
authors.affiliation: Department of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning Province, 116024, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xie
authors.affiliation: Department of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning Province, 116024, PR China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Shao
authors.affiliation: Department of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning Province, 116024, PR China.
authors.forename: Aziz Ur Rehman
authors.initials: AUR
authors.lastname: Aziz
authors.affiliation: Department of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning Province, 116024, PR China.
authors.forename: Baohong
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Center for Translational Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei Province, 441300, PR China.
authors.forename: Hanqin
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning Province, 116024, PR China. Electronic address: lbo@dlut.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology; D010766:Phosphorylation; D015398:Signal Transduction; D062948:rho Guanine Nucleotide Dissociation Inhibitor alpha / Q000378:metabolism*
chemical_list: D062948:rho Guanine Nucleotide Dissociation Inhibitor alpha; D020558:GTP Phosphohydrolases
keywords: Cell migration; External environment; Non-kinase; Post-translational modification; Rho GTPases; RhoGDIα