title: Factors that may influence polymorphous low-grade adenocarcinoma growth.
abstract: There is mounting evidence on the importance of some biological processes in tumor growth, such as vascular supply, apoptosis, autophagy, and senescence. We have investigated these processes in polymorphous low-grade adenocarcinoma (PLGA), in an attempt to identify those that are relevant for this particular lesion. We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. Our results showed that PLGA growth does not depend on newly formed vessels but only on preexisting vasculature. Furthermore, PLGA is promoted by autophagy, sustained by both anti-apoptotic and anti-senescence signals, and stimulated by Bcl-2 and survivin.
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil. andresabs@hotmail.com.
authors.forename: Andresa Borges
authors.initials: AB
authors.lastname: Soares
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
authors.forename: Elizabeth Ferreira
authors.initials: EF
authors.lastname: Martinez
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
authors.forename: Patricia Fernandes Avila
authors.initials: PF
authors.lastname: Ribeiro
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
authors.forename: Icleia Siqueira
authors.initials: IS
authors.lastname: Barreto
authors.affiliation: Department of Oral Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Maria Cássia
authors.initials: MC
authors.lastname: Aguiar
authors.affiliation: Department of Oral Pathology, State University of São Paulo, Araçatuba, SP, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Furuse
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Sperandio
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
authors.forename: Victor Angelo
authors.initials: VA
authors.lastname: Montalli
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
authors.forename: Ney Soares
authors.initials: NS
authors.lastname: de Araújo
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
authors.forename: Vera Cavalcanti
authors.initials: VC
authors.lastname: de Araújo
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000502:physiology; D001343:Autophagy / Q000502:physiology; D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Angiogenesis; Apoptosis; Autophagy; Bcl2; LC3B; Polymorphous low-grade adenocarcinoma; Senescence; Survivin