title: Ibrutinib Is Effective in the Treatment of Autoimmune Haemolytic Anaemia in Mantle Cell Lymphoma.
abstract: Autoimmune haemolytic anaemia (AIHA) in mantle cell lymphoma (MCL) is a rare but life-threatening complication. To date, there are no relevant data for treatment of AIHA in MCL. Ibrutinib, which has been approved for relapse/refractory MCL, is an immunomodulatory drug inhibiting Th2 activation and consequently the production of autoantibodies. We report a case of MCL with AIHA in which this form of anaemia was not controlled with the usual chemotherapy. Ibrutinib was used when MCL with AIHA relapsed, and it allowed rapid remission of AIHA and rapid discontinuation of steroid therapy.
authors.affiliation: CHU de Poitiers, Service d'Onco-Hématologie et Thérapie Cellulaire, Poitiers, France.
authors.forename: Aliénor
authors.initials: A
authors.lastname: Galinier
authors.affiliation: CHU de Poitiers, Service d'Onco-Hématologie et Thérapie Cellulaire, Poitiers, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Delwail
authors.affiliation: CHU de Poitiers, Service d'Onco-Hématologie et Thérapie Cellulaire, Poitiers, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Puyade
keywords: Autoimmune hemolytic anaemia; Ibrutinib; Mantle cell lymphoma