title: Enantioselective Aza-Ene-type Reactions of Enamides with Gold Carbenes Generated from α-Diazoesters.
abstract: Carbophilic gold carbenes generated from the decomposition of α-diazoesters show high reactivity towards enamides, leading to an unprecedented aza-ene-type reaction. The presence of 0.1 mol % of a chiral Brønsted acid co-catalyst is sufficient to give synthetically relevant γ-keto esters in excellent yields and selectivities (up to 99 % yield, 97 % ee).
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Han
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Shi-Wei
authors.initials: SW
authors.lastname: Luo
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, China.
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
keywords: Brønsted acids; asymmetric protonation; aza-ene reactions; gold carbenes; relay catalysis