title: Effects of contact network structure on epidemic transmission trees: implications for data required to estimate network structure.
abstract: Understanding the dynamics of disease spread is key to developing effective interventions to control or prevent an epidemic. The structure of the network of contacts over which the disease spreads has been shown to have a strong influence on the outcome of the epidemic, but an open question remains as to whether it is possible to estimate contact network features from data collected in an epidemic. The approach taken in this paper is to examine the distributions of epidemic outcomes arising from epidemics on networks with particular structural features to assess whether that structure could be measured from epidemic data and what other constraints might be needed to make the problem identifiable. To this end, we vary the network size, mean degree, and transmissibility of the pathogen, as well as the network feature of interest: clustering, degree assortativity, or attribute-based preferential mixing. We record several standard measures of the size and spread of the epidemic, as well as measures that describe the shape of the transmission tree in order to ascertain whether there are detectable signals in the final data from the outbreak. The results suggest that there is potential to estimate contact network features from transmission trees or pure epidemic data, particularly for diseases with high transmissibility or for which the relevant contact network is of low mean degree. Copyright © 2017 John Wiley & Sons, Ltd.
authors.affiliation: Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee.
authors.forename: Nicole Bohme
authors.identifier: http://orcid.org/0000-0001-7664-6682
authors.initials: NB
authors.lastname: Carnegie
mesh_terms: D050936:Basic Reproduction Number / Q000706:statistics & numerical data; D056808:Biostatistics / Q000379:methods; D016000:Cluster Analysis; D003198:Computer Simulation; D016358:Contact Tracing / Q000706:statistics & numerical data; D018562:Disease Transmission, Infectious / Q000517:prevention & control / Q000706:statistics & numerical data*; D058872:Epidemics / Q000517:prevention & control / Q000706:statistics & numerical data*; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D013269:Stochastic Processes
keywords: ERGM; assortativity; clustering; epidemic model