title: Psoriasis and cardiovascular events: updating the evidence.
abstract: So far, systematic reviews have suggested an increased risk of cardiovascular diseases (CVD) in psoriatic patients, though some results have been conflicting. The aim of this study was to update the current level of evidence through a systematic search in MEDLINE, EMBASE and Cochrane Central Register databases. In total, 13 high-quality observational studies estimating the incidence of CVD were included. Patients with mild psoriasis had an increased risk of stroke [Hazard ratio (HR) = 1.10, 95% CI: 1.0-1.19] and myocardial infarction (MI) (HR = 1.20, 95% CI: 1.06-1.35), but not cardiovascular death. The risks of both stroke (HR = 1.38, 95% CI: 1.20-1.60), MI (HR = 1.70, 95% CI: 1.18-2.43) and cardiovascular death (HR = 1.37, 95% CI: 1.13-1.67) were increased in patients with severe psoriasis. In conclusion, this updated meta-analysis confirmed that patients with psoriasis have an increased risk of CVD, especially those with severe psoriasis.
authors.affiliation: Department of Dermatology, Aarhus University Hospital, P.P. Oerumsgade 11, building 15b, 8000, Aarhus, Denmark. line.raaby@clin.au.dk.
authors.forename: Line
authors.identifier: http://orcid.org/0000-0002-3327-9613
authors.initials: L
authors.lastname: Raaby
authors.affiliation: Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Ahlehoff
authors.affiliation: Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.|Department of Rheumatology, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus, Denmark.
authors.forename: Annette
authors.initials: A
authors.lastname: de Thurah
mesh_terms: D006801:Humans; D015994:Incidence; D009203:Myocardial Infarction / Q000453:epidemiology*; D011565:Psoriasis / Q000453:epidemiology*; D012306:Risk; D020521:Stroke / Q000453:epidemiology*
keywords: Cardiovascular death; Cardiovascular diseases; Meta-analysis; Myocardial infarction; Psoriasis; Stroke