title: Cell-mediated delivery of synthetic nano- and microparticles.
abstract: Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to explore cell surface modification strategies for the cellular hitchhiking of synthetic nano- and microparticles. The first part of this article will present and discuss the different types of cells that have been explored for cell mediated drug delivery. The second part of this review will discuss the various chemical strategies that have been elaborated for the conjugation or immobilization of nano- and microparticles on the surface of these cells.
authors.affiliation: École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, CH-1015 Lausanne, Switzerland. Electronic address: maxime.ayer@epfl.ch.
authors.forename: Maxime
authors.initials: M
authors.lastname: Ayer
authors.affiliation: École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, CH-1015 Lausanne, Switzerland. Electronic address: harm-anton.klok@epfl.ch.
authors.forename: Harm-Anton
authors.initials: HA
authors.lastname: Klok
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D004912:Erythrocytes; D006801:Humans; D007962:Leukocytes; D053758:Nanoparticles / Q000008:administration & dosage*; D013234:Stem Cells
keywords: Cell surface-conjugation; Cell-mediated drug delivery; Cellular backpacks; Cellular hitchhiking; Nano- and microparticles