title: Estrone and Estradiol Levels in Breast Cancer Patients Using Anastrozole Are Not Related to Body Mass Index.
abstract: ObjectiveObesity is associated with an increased risk for breast cancer. Recent studies have shown that aromatase inhibitors may be less effective in women with a high body mass index (BMI). The aim of this study was to establish the relationship between the BMI and plasma estrone and estradiol levels in postmenopausal women with hormone receptor-positive breast cancer using anastrozole.MethodsIn this cohort study, the patients were divided into three groups according to BMI (normal weight, overweight and obese) to compare and correlate plasma hormone levels before starting anastrozole hormone therapy and three months after treatment. Plasma hormone levels were compared for age and use of chemotherapy.ResultsA statistically significant reduction in estrone and estradiol levels was observed between baseline and three months after starting the anastrozole treatment (p< 0.05). There was no statistically significant difference in plasma estrone and estradiol levels among the BMI groups (p> 0.05), but a significant reduction in plasma estrone levels was observed after three-months' treatment relative to baseline in all groups, as well as a reduction in estradiol in the obese group (p< 0.05). The use of chemotherapy and age > 65 years had no influence on plasma steroid levels.ConclusionChanges in estrone and estradiol levels in the studied groups were not associated with BMI, chemotherapy or age.
authors.affiliation: Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, São Paulo, Brazil.
authors.forename: Eduardo Borges
authors.initials: EB
authors.lastname: Coscia
authors.affiliation: Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, São Paulo, Brazil.
authors.forename: Maricene
authors.initials: M
authors.lastname: Sabha
authors.affiliation: Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, São Paulo, Brazil.
authors.forename: Marli
authors.initials: M
authors.lastname: Gerenutti
authors.affiliation: Department of Pharmacology, Anesthesiology and Therapeutics, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Brazil.
authors.forename: Francisco Carlos
authors.initials: FC
authors.lastname: Groppo
authors.affiliation: Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, São Paulo, Brazil.
authors.forename: Cristiane de Cássia
authors.initials: CC
authors.lastname: Bergamaschi
mesh_terms: D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy*; D015331:Cohort Studies; D004958:Estradiol / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D004970:Estrone; D000077384:Anastrozole; D004958:Estradiol