title: Central Role of Metabolism in Endothelial Cell Function and Vascular Disease.
abstract: The importance of endothelial cell (EC) metabolism and its regulatory role in the angiogenic behavior of ECs during vessel formation and in the function of different EC subtypes determined by different vascular beds has been recognized only in the last few years. Even more importantly, apart from a role of nitric oxide and reactive oxygen species in EC dysfunction, deregulations of EC metabolism in disease only recently received increasing attention. Although comprehensive metabolic characterization of ECs still needs further investigation, the concept of targeting EC metabolism to treat vascular disease is emerging. In this overview, we summarize EC-specific metabolic pathways, describe the current knowledge on their deregulation in vascular diseases, and give an outlook on how vascular endothelial metabolism can serve as a target to normalize deregulated endothelium.
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; and.|Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, University of Leuven, Leuven, Belgium.
authors.forename: Laura
authors.initials: L
authors.lastname: Bierhansl
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; and.|Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, University of Leuven, Leuven, Belgium.
authors.forename: Lena-Christin
authors.initials: LC
authors.lastname: Conradi
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; and.|Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, University of Leuven, Leuven, Belgium.
authors.forename: Lucas
authors.initials: L
authors.lastname: Treps
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; and.|Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, University of Leuven, Leuven, Belgium.
authors.forename: Mieke
authors.initials: M
authors.lastname: Dewerchin
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; and peter.carmeliet@kuleuven.vib.be.|Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, University of Leuven, Leuven, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis; D006595:Hexosamines / Q000096:biosynthesis; D006801:Humans; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D010427:Pentose Phosphate Pathway; D014652:Vascular Diseases / Q000150:complications / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D006595:Hexosamines; D005973:Glutamine; D006003:Glycogen; D001120:Arginine