title: Side-to-side duodeno-colic anastomosis provides dramatic weight loss. A potentially strong anti-diabetic operation for type-2 diabetes.
abstract: BACKGROUND
  Incomplete bypass of the intestines provides weight loss by hypoabsorption of nutrients and hormonal changes. The aim was to evaluate the efficacy and safety of a side-to-side duodeno-colic anastomosis (DCA) in the short term.
  
  
  METHODS
  Seven <50 kg swine were allocated to a DCA, and compared to a sham group. Weights were recorded for 8 weeks and duodenoscopies performed at 8 and 28 days. Complete blood count and basic biochemistry profiles were taken at baseline, day 3 and 56. At necropsy, macroscopic and histological changes of the liver, duodenum and colon samples were analyzed.
  
  
  RESULTS
  The DCA group has shown a weight loss of 18.2%, while the control group gained 33.2% more weight at 56 days, for a dramatic difference of 51.4% between the 2 groups (P<0.05). Duodenoscopies demonstrated normal patent anastomosis and adequate lumen without abnormalities at 28 days. Histological anastomosis examination at 56 days showed normal healing, with absence of severe liver toxicity.
  
  
  CONCLUSIONS
  In this mammal model with short follow-up, a side-to-side duodeno-colic anastomosis provided rapid efficacious weight loss in the short term.
authors.affiliation: Department of Surgery, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA - gagner.michel@gmail.com.|Department of Surgery, Sacre Coeur Hospital, Montreal, QC, Canada - gagner.michel@gmail.com.
authors.forename: Michel
authors.initials: M
authors.lastname: Gagner
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D015992:Body Mass Index; D003106:Colon / Q000601:surgery*; D003921:Diabetes Mellitus, Experimental; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004386:Duodenum / Q000601:surgery*; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000209:etiology / Q000601:surgery*; D013552:Swine; D016896:Treatment Outcome; D015431:Weight Loss