title: Dysregulation of miRNAs in bladder cancer: altered expression with aberrant biogenesis procedure.
abstract: Aberrant expression profiles of miRNAs are widely observed in the clinical tissue specimens and urine samples as well as the blood samples of bladder cancer patients. These profiles are closely related to the pathological features of bladder cancer, such as the tumour stage/grade, metastasis, recurrence and chemo-sensitivity. MiRNA biogenesis forms the basis of miRNA expression and function, and its dysregulation has been shown to be essential for variations in miRNA expression profiles as well as tumourigenesis and cancer progression. In this review, we summarize the up-to-date and widely reported miRNAs in bladder cancer that display significantly altered expression. We then compare the miRNA expression profiles among three different sample types (tissue, urine and blood) from patients with bladder cancer. Moreover, for the first time, we outline the dysregulated miRNA biogenesis network in bladder cancer from different levels and analyse its possible relationship with aberrant miRNA expression and the pathological characteristics of the disease.
authors.affiliation: Department of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Tianyuan
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhong
authors.affiliation: Department of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Shanwen
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.affiliation: Department of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Zhoujun
authors.initials: Z
authors.lastname: Shen
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D014644:Genetic Variation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016366:Open Reading Frames; D020871:RNA Stability; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors
keywords: biogenesis procedure; bladder cancer; expression profile; microRNA