title: Fasting leptin and glucose in normal weight, over weight and obese men and women diabetes patients with and without clinical depression.
abstract: A large number of diabetes patients suffer from major depression and are at high risk of mortality. In view of a role of leptin in diabetes, depression and energy homeostasis, the present study concerns circulating levels of leptin in different BMI groups of un-depressed and depressed diabetes patients. Six hundred thirty male and female patients with a primary diagnosis of diabetes were grouped according to BMI and with or without clinical symptoms of depression. Age matched healthy, normal weight male and female volunteers without clinical symptoms of depression or diabetes were taken as controls. Blood samples were obtained after an overnight fast of 12 h. Serum was stored for the determination of leptin and glucose. We found that there were more female than male diabetes patients with comorbid depression. Fasting leptin was higher in normal weight non-diabetes women than men; but comparable in normal weight men and women diabetes patients. Fasting glucose levels were higher in diabetes than non diabetes groups; values were comparable in men and women. Depression was associated with a decrease and increase in leptin respectively in normal-overweight and obese men and women diabetes patients. Glucose levels were also higher in obese depressed than un-depressed diabetes patients. The results suggested that the female gender is at greater risk to comorbid diabetes with depression. Adipo-insular axis plays an important role in diabetes, associated depression and in the greater risk of the female gender to comorbid diabetes with depression.
authors.affiliation: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, 75270, Pakistan.
authors.forename: Darakhshan Jabeen
authors.initials: DJ
authors.lastname: Haleem
authors.affiliation: Department of Biochemistry, Liaquat National Hospital & Medical College, Karachi, Pakistan.
authors.forename: Shehnaz
authors.initials: S
authors.lastname: Sheikh
authors.affiliation: Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan.
authors.forename: Asher
authors.initials: A
authors.lastname: Fawad
authors.affiliation: Department of Biomedical Engineering, Sir Syed University of Engineering and Technology, Karachi, 75300, Pakistan.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Haleem
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D003865:Major Depressive Disorder / Q000097:blood* / Q000453:epidemiology / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000523:psychology; D005215:Fasting / Q000097:blood / Q000523:psychology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000523:psychology; D050177:Overweight / Q000097:blood* / Q000453:epidemiology / Q000523:psychology; D012727:Sex Characteristics
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D020738:Leptin
keywords: Adipo-insular axis; Depression; Diabetes; Gender difference; Leptin; Obesity