title: Persistent RNA virus infections: do PAMPS drive chronic disease?
abstract: Chronic disease associated with persistent RNA virus infections represents a key public health concern. While human immunodeficiency virus-1 and hepatitis C virus are perhaps the most well-known examples of persistent RNA viruses that cause chronic disease, evidence suggests that many other RNA viruses, including re-emerging viruses such as chikungunya virus, Ebola virus and Zika virus, establish persistent infections. The mechanisms by which RNA viruses drive chronic disease are poorly understood. Here, we discuss how the persistence of viral RNA may drive chronic disease manifestations via the activation of RNA sensing pathways.
authors.affiliation: Department of Immunology and Microbiology, University of Colorado School of Medicine, USA.
authors.forename: Mary K
authors.initials: MK
authors.lastname: McCarthy
authors.affiliation: Department of Immunology and Microbiology, University of Colorado School of Medicine, USA. Electronic address: thomas.morrison@ucdenver.edu.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Morrison
mesh_terms: D002908:Chronic Disease; D054884:Host-Pathogen Interactions; D006801:Humans; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000378:metabolism*; D012327:RNA Virus Infections / Q000276:immunology* / Q000821:virology*; D012328:RNA Viruses / Q000276:immunology*
chemical_list: D000069452:Pathogen-Associated Molecular Pattern Molecules