title: High tumor-infiltrating FoxP3+T cells predict poor survival in estrogen receptor-positive breast cancer: A meta-analysis.
abstract: OBJECTIVE
  Tumor-infiltrating FoxP3+T cells and FoxP3+tumor cells have been reported in breast cancer (BC), which impaired immunity and promoted tumors progression. However, their prognostic value for survival in patients with breast BC remains controversial.
  
  
  METHODS
  A meta-analysis was performed. Original data included the hazard ratios (HR) of overall survival (OS), relapse-free survival and odds ratio (OR) in BC patients. We pooled HR/OR with 95% confidence intervals (CI) to estimate the hazard.
  
  
  RESULTS
  The overall survival of high tumor-infiltrating FoxP3+T cells patients was lower than low tumor-infiltrating FoxP3+T cells patients with estrogen receptor (ER)-positive (HR 0.86, 95% CI 0.77-0.96; P = 0.009) but not ER-negative (HR 1.09, 95% CI 0.82-1.45; P = 0.569) BC. And FoxP3+tumor cells were not associated with the overall survival and recurrences of BC patients (P > 0.05). In addition, a significant association was revealed between high tumor-infiltrating FoxP3+T cells and grade (I + II/III: OR 0.31, 95% CI 0.17-0.56; P < 0.001), ER status (present: OR 2.39, 95% CI 1.51-3.76; P < 0.001), HER2 status (present: OR 0.53, 95% CI 0.36-0.78; P = 0.001), PR status (present: OR 1.88, 95% CI 1.31-2.71; P < 0.001). And a significant association was revealed between positive FoxP3+tumor cells and Nodal status (present: OR 0.48, 95% CI 0.23-0.97; P = 0.04), grade (I + II/III: OR 0.44, 95% CI 0.22-0.85; P = 0.01), PR status (present: OR 2.37, 95% CI 1.54-3.36; P < 0.001).
  
  
  CONCLUSIONS
  High tumor-infiltrating FoxP3+T cells were associated with a poorer prognosis for ER-positive BC, but not for ER-negative BC.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: F
authors.initials: F
authors.lastname: Qian
authors.affiliation: Department of Assisted Reproductive, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Qingping
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: W
authors.initials: W
authors.lastname: Linquan
authors.affiliation: Department of Assisted Reproductive, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: H
authors.initials: H
authors.lastname: Xiaojin
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Gannan Medical, Ganzhou 341000, China.
authors.forename: W
authors.initials: W
authors.lastname: Rongshou
authors.affiliation: Department of Operating Room, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: R
authors.initials: R
authors.lastname: Shanshan
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: L
authors.initials: L
authors.lastname: Wenjun
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. Electronic address: huangyong2004373@163.com.
authors.forename: H
authors.initials: H
authors.lastname: Yong
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. Electronic address: lienliangyx@163.com.
authors.forename: L
authors.initials: L
authors.lastname: Enliang
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D051858:Forkhead Transcription Factors / Q000032:analysis*; D006801:Humans; D008207:Lymphatic Metastasis; D016246:Lymphocytes, Tumor-Infiltrating / Q000737:chemistry* / Q000276:immunology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis; D015996:Survival Rate; D013601:T-Lymphocytes / Q000737:chemistry* / Q000276:immunology
chemical_list: D051858:Forkhead Transcription Factors; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C418974:FOXP3 protein, human; C508053:ERBB2 protein, human
keywords: Breast cancer; Estrogen receptor; FoxP3; Prognostic