title: Hemolytic uremic syndrome complicated by Clostridium septicum bacteremia and new-onset type 1 diabetes mellitus. Report of a case .
abstract: We report the unusual case of a 5-year-old male hospitalized for management of diabetic ketoacidosis (DKA) and new-onset type 1 diabetes mellitus (T1DM) who developed acute renal injury secondary to hemolytic uremic syndrome (HUS). He was diagnosed with Shiga toxin-producing entero-hemorrhagicEscherichia coli(EHEC) 0157:H7-positive HUS 48 hours after being diagnosed with new-onset T1DM/DKA. His hospital course was complicated byClostridium septicumsepsis with colonic perforation. This patient's diagnosis of new-onset T1DM just prior to HUS is novel. Furthermore, some cases of HUS and concurrent atraumaticC. septicuminfection have been documented, but only two other survivor cases have been found, and no previous cases report of concurrent T1DM complicating atraumaticC. septicuminfection have been documented so far. Aggressive surgical management and appropriate early antibiotic therapy may have been important for this child's survival. .
authors.forename: Anna C
authors.initials: AC
authors.lastname: Iddings
authors.forename: Asha N
authors.initials: AN
authors.lastname: Shenoi
authors.forename: Alba
authors.initials: A
authors.lastname: Morales Pozzo
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Kiessling
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications*; D002675:Child, Preschool; D003015:Clostridium Infections / Q000150:complications*; D052557:Clostridium septicum; D003082:Colectomy; D003108:Colonic Diseases / Q000209:etiology / Q000601:surgery; D003125:Colostomy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D016883:Diabetic Ketoacidosis / Q000150:complications*; D054324:Enterohemorrhagic Escherichia coli; D004927:Escherichia coli Infections / Q000150:complications* / Q000188:drug therapy; D006463:Hemolytic-Uremic Syndrome / Q000150:complications; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology / Q000601:surgery; D008297:Male; D065666:Mesenteric Ischemia / Q000209:etiology / Q000601:surgery; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents