title: The Ferguson Operating Anoscope for Resection of T1 Rectal Cancer.
abstract: The Ferguson Operating Anoscope (FOA) is a surgical instrument, which can facilitate transanal excision of appropriate rectal tumors within 15 cm of the anal verge. Previous work showed low recurrence (4.3%) for favorable T1 tumors (no lymphovascular invasion, well/moderate differentiation, negative margins). This follow-up study evaluates outcomes in rectal cancer excised with FOA at a tertiary care center. T1 rectal cancer patients were identified in a prospectively maintained database. Tumor pathology and patient characteristics were reviewed. Primary outcomes include tumor recurrence and patient and disease-free survival. Secondary outcomes are quality of excision (intact specimen). Twenty-eight patients had pathologic stage T1 rectal cancer (average 8 ± 2.6 cm from the anal verge). Final path demonstrated 14 per cent to be well differentiated, 82 per cent moderately differentiated, and 93 per cent without angiolymphatic invasion. All specimens removed were intact. One patient had a true local recurrence and underwent a salvage operation 24 months after her index operation. Patient survival was 96.4 per cent (n = one death from primary lung cancer) at median follow-up 64 ± 35 months. With appropriate tumor selection and quality of initial resection, FOA has demonstrated utility in achieving optimal oncologic resection of T1 rectal tumors.
authors.affiliation: The University of Tennessee College of Medicine Chattanooga, Chattanooga, Tennessee, USA.
authors.forename: Kristin C
authors.initials: KC
authors.lastname: Turza
authors.forename: Thomas
authors.initials: T
authors.lastname: Brien
authors.forename: Steven
authors.initials: S
authors.lastname: Porbunderwala
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Bell
authors.forename: Shauna
authors.initials: S
authors.lastname: Lorenzo-Rivero
authors.forename: Richard A
authors.initials: RA
authors.lastname: Moore
authors.forename: Eric C
authors.initials: EC
authors.lastname: Nelson
authors.forename: J Daniel
authors.initials: JD
authors.lastname: Stanley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D020700:Proctoscopes; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016879:Salvage Therapy; D000067368:Transanal Endoscopic Surgery / Q000295:instrumentation*; D016896:Treatment Outcome