title: Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter.
abstract: Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns.
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute , Bethesda, MD, USA.
authors.forename: Veenu
authors.initials: V
authors.lastname: Tripathi
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute , Bethesda, MD, USA.
authors.forename: Ying E
authors.initials: YE
authors.lastname: Zhang
keywords: Alternative splicing; EMT; PCBP1; SMAD3; TGF-β; metastasis