title: Evaluation of Possible Consequences of Zika Virus Infection in the Developing Nervous System.
abstract: The Zika virus (ZIKV) outbreak that occurred in the northeast of Brazil in 2015 led to alarming numbers of babies born with microcephaly in this region. Since then, several studies have evaluated the relationship between ZIKV infection and development of the malformation although the specific mechanistic interaction between ZIKV and human physiological processes that ultimately manifest as microcephaly remains debated. Importantly, most current studies did not consider the specificities of the biology and life cycle of ZIKV. As a consequence, specificities of the infection on the developing central nervous system (CNS) were frequently disregarded. In order to begin to address this important gap in our knowledge, we have collated and critically reviewed the existing evidence in this area to identify any emerging consensus on this topic and thereafter describe possible mechanisms by which ZIKV infection could interfere with specific processes of CNS development, such as neuronal proliferation, and the complex interactions of immature neurons with radial glial cells. With this, we were able to present the current knowledge on this important topic in the neurobiology field.
authors.affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.
authors.forename: Lais Takata
authors.initials: LT
authors.lastname: Walter
authors.affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.|Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Guilherme Shigueto Vilar
authors.initials: GSV
authors.lastname: Higa
authors.affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.
authors.forename: Juliane Midori
authors.initials: JM
authors.lastname: Ikebara
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.
authors.forename: Danila
authors.initials: D
authors.lastname: Vedovello
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Felipe Scassi
authors.initials: FS
authors.lastname: Salvador
authors.affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.
authors.forename: Silvia Honda
authors.initials: SH
authors.lastname: Takada
authors.affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.
authors.forename: Erika Reime
authors.initials: ER
authors.lastname: Kinjo
authors.affiliation: School of Chemistry, Food and Nutritional Sciences, and Pharmacy, University of Reading, Whiteknights, Berkshire, Reading, UK.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Whalley
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.
authors.forename: Márcia Aparecida
authors.initials: MA
authors.lastname: Sperança
authors.affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil. alexandrekihara@gmail.com.|Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil. alexandrekihara@gmail.com.
authors.forename: Alexandre Hiroaki
authors.initials: AH
authors.lastname: Kihara
mesh_terms: D049109:Cell Proliferation; D002490:Central Nervous System / Q000254:growth & development* / Q000821:virology*; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D008831:Microcephaly / Q000821:virology*; D009474:Neurons / Q000821:virology; D000071244:Zika Virus; D000071243:Zika Virus Infection
keywords: Disease; Infection; Microcephaly; Neurodevelopment; Virulence