title: Association between thyroid cancer and epidermal growth factor receptor mutation in female with nonsmall cell lung cancer.
abstract: BACKGROUND
  The aim of this study was to investigate the association between epidermal growth factor receptor (EGFR) mutation and thyroid cancer in female patients with nonsmall-cell lung cancer (NSCLC).
  
  
  METHODS
  In a retrospective study, we examined 835 female patients who were diagnosed with NSCLC and underwent anEGFRmutation test between June 2003 and August 2013. The associations ofEGFRmutation with thyroid cancer and a family history of thyroid cancer were evaluated using logistic regression models.
  
  
  RESULTS
  EGFRmutation was found in 378 of 835 patients. In addition to adenocarcinoma (P< 0.001),EGFRmutations were positively associated with a personal history of thyroid cancer (5.8% versus 2.6%;P= 0.020), while showing a trend toward inverse association with a personal history of nonthyroid cancer (5.8% vs. 9.0%;P= 0.086). Likewise, the incidence ofEGFRmutations was associated with a family history of thyroid cancer (2.9% vs. 0.9%;P= 0.028), while showing a trend toward inverse association with a family history of nonthyroid cancer (27.8% vs. 33.7%;P= 0.066). Multivariate logistic regression showed that the incidence ofEGFRmutations was different in women with thyroid or nonthyroid cancer (P= 0.035) and in women with a family history of thyroid or nonthyroid cancer (P= 0.023).
  
  
  CONCLUSIONS
  Our data suggest that thyroid cancer and a family history of thyroid cancer are associated withEGFR-mutated NSCLC in female patients. The differences in the incidence of thyroid cancer and a family history of thyroid cancer byEGFRmutational status provide new insight into pathogenesis of this genetic change.
authors.affiliation: Department of Internal Medicine, Division of Pulmonology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
authors.forename: Seo Yun
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Division of Pulmonology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
authors.forename: Hye-Ryoun
authors.initials: HR
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Division of Pulmonology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
authors.forename: Cheol Hyeon
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
authors.forename: Jae Soo
authors.initials: JS
authors.lastname: Koh
authors.affiliation: Department of Thoracic Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
authors.forename: Hee Jong
authors.initials: HJ
authors.lastname: Baek
authors.affiliation: Department of Pulmonology and Critical Care Medicine, University of Ulsan, Ulsan, Republic of Korea; Department of Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Ulsan, Republic of Korea.
authors.forename: Chang-Min
authors.initials: CM
authors.lastname: Choi
authors.affiliation: Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Ulsan, Republic of Korea.
authors.forename: Joon Seon
authors.initials: JS
authors.lastname: Song
authors.affiliation: Department of Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Ulsan, Republic of Korea.
authors.forename: Jae Cheol
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
authors.forename: Im Ii
authors.initials: II
authors.lastname: Na
keywords: Epidermal growth factor receptor; female; nonsmall cell lung carcinoma; thyroid neoplasm