title: Association of serum uric acid with subsequent arterial stiffness and renal function in normotensive subjects.
abstract: Serum uric acid (SUA) is correlated with an increased risk of not only gout but also cardiovascular diseases. The present study aimed to longitudinally evaluate the effects of SUA level on renal function and arterial stiffness in a population-based sample of normotensive subjects. The subjects completed a health checkup in 2002 at baseline and in 2011 or 2012 at the end of the follow-up period. A total of 407 normotensive subjects (171 men and 236 women) aged 26-66 years were enrolled in this study. We measured blood pressure (BP), brachial-ankle pulse wave velocity (baPWV), central BP, intima-media thickness, SUA level and estimated glomerular filtration rate (eGFR). We divided the subjects into four subgroups according to the SUA quartile at baseline and compared renal function and arterial stiffness after the follow-up. The cutoff values were 3.6, 4.4, 5.6 and 9.6 mg dl-1. The SUA levels associated with baPWV (Q1, 1324; Q2, 1457; Q3, 1442; Q4, 1489 cm s-1), systolic BP (SBP) (Q1, 110.9; Q2, 110.1; Q3, 112.8; Q4. 116.1 mm Hg) and eGFR (P for trend <0.001). There was a significant difference in the incidence of arterial stiffness in women. Multivariate regression analyses showed that after adjusting for potential confounders, including age, sex, body mass index, SBP and lipids, SUA was a significant determinant of baPWV (β=0.117; P<0.05) and eGFR (β=-0.335, P<0.001). The results of this study suggest that elevated SUA levels may be associated with a higher risk of increased arterial stiffness and reduced renal function in normotensive subjects.
authors.affiliation: Wakayama Medical University Graduate School of Health and Nursing Science, Wakayama, Japan.
authors.forename: Shiori
authors.initials: S
authors.lastname: Nagano
authors.affiliation: Wakayama Medical University Graduate School of Health and Nursing Science, Wakayama, Japan.
authors.forename: Maasa
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Wakayama Medical University Graduate School of Health and Nursing Science, Wakayama, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyai
authors.affiliation: Wakayama Medical University Graduate School of Health and Nursing Science, Wakayama, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Oka
authors.affiliation: Wakayama Medical University Graduate School of Health and Nursing Science, Wakayama, Japan.
authors.forename: Miyoko
authors.initials: M
authors.lastname: Utsumi
authors.affiliation: Wakayama Medical University Graduate School of Health and Nursing Science, Wakayama, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Shiba
authors.affiliation: Department of Public Health,Wakayama Medical University, Wakayama, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Mure
authors.affiliation: Department of Public Health,Wakayama Medical University, Wakayama, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takeshita
authors.affiliation: Wakayama Medical University Graduate School of Health and Nursing Science, Wakayama, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Arita
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*; D059289:Vascular Stiffness
chemical_list: D014527:Uric Acid