title: Clinicopathologic and prognostic significance of human epidermal growth factor receptor in patients with gastric cancer: An updated meta-analysis.
abstract: OBJECTIVE
  The aim of this update meta-analysis was to clarify the clinicopathologic and prognostic significance of human epidermal growth factor receptor(EGFR) expression in gastric cancer patients.
  
  
  METHODS
  Several electronic databases were searched from January 1970 to May 2016. The odds ratio (OR) was calculated to assess the association between EGFR expression and pathological parameters. The hazard ratio (HR) and 95% CI were calculated to explore the relationship between EGFR expression and overall survival.
  
  
  RESULTS
  Finally 7229 patients with gastric cancer from 25 eligible studies were included in the present meta analysis. High EGFR expression was found to be significantly related with tumor differentiation (OR=1.96, 95%CI: 1.14-3.34, Z=2.43, P=0.015), lymph node metastasis (OR=2.20, 95% CI: 1.63-2.96, Z=5.17, P=0.001), and tumor stage (OR=2.13, 95% CI: 1.35-3.36, Z=3.25, P=0.001). However, high EGFR expression was not significantly associated with invasion depth (OR=2.09, 95% CI: 0.4-11.05, Z=0.87, P=0.385). The pooled HR suggested that high EGFR expression was significantly correlated with overall survival (HR=1.19, 95% CI 1.04-1.37, Z=2.44, P=0.015).
  
  
  CONCLUSIONS
  The present meta-analysis demonstrated that high EGFR expression significantly predicts poor prognosis, suggesting that high EGFR expression may serve as a predictive biomarker for poor prognosis in patients with gastric cancer.
authors.affiliation: Department of Infectious Disease, The First People's Hospital of Shunde, Shunde, Guangdong, China.|Department of Internal Medicine, The Chencun Hospital Affiliated to The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Zhiqiao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Science and Education, The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Internal Medicine, The Chencun Hospital Affiliated to The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Jixin
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Infectious Disease, The First People's Hospital of Shunde, Shunde, Guangdong, China.|Department of Internal Medicine, The Chencun Hospital Affiliated to The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Yunzhao
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Infectious Disease, The First People's Hospital of Shunde, Shunde, Guangdong, China.|Department of Internal Medicine, The Chencun Hospital Affiliated to The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Guanying
authors.initials: G
authors.lastname: Luo
authors.affiliation: Department of Internal Medicine, The Chencun Hospital Affiliated to The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Zhaowen
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Infectious Disease, The First People's Hospital of Shunde, Shunde, Guangdong, China.|Department of Internal Medicine, The Chencun Hospital Affiliated to The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Canchang
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Department of Infectious Disease, The First People's Hospital of Shunde, Shunde, Guangdong, China.|Department of Internal Medicine, The Chencun Hospital Affiliated to The First People's Hospital of Shunde, Shunde, Guangdong, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005753:Gastric Mucosa / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012680:Sensitivity and Specificity; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors
keywords: gastric cancer; human epidermal growth factor receptor; meta-analysis; prognostic significance