title: Androgen Receptor Signaling in Salivary Gland Cancer.
abstract: Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular biology and clinical presentation. Local disease is potentially curable with surgery, which may be combined with adjuvant radiotherapy. However, metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis. Recent molecular studies have shown evidence of androgen receptor signaling in several types of salivary gland cancer, mainly salivary duct carcinoma. Successful treatment with anti-androgen therapy in other androgen receptor-positive malignancies such as prostate and breast cancer has inspired researchers to investigate this treatment in salivary gland cancer as well. In this review, we describe the prevalence, biology, and therapeutic implications of androgen receptor signaling in salivary gland cancer.
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. martin.dalin@gu.se.|Department of Pediatrics, Institution for Clinical Sciences, University of Gothenburg, Gothenburg SE-416 86, Sweden. martin.dalin@gu.se.
authors.forename: Martin G
authors.initials: MG
authors.lastname: Dalin
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. watsonp@mskcc.org.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Watson
authors.affiliation: Head and Neck Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. hoa@mskcc.org.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Ho
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. morrisl@mskcc.org.|Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. morrisl@mskcc.org.
authors.forename: Luc G T
authors.initials: LG
authors.lastname: Morris
keywords: androgen receptor; androgen-deprivation therapy (ADT); salivary duct carcinoma; salivary gland cancer