title: Recent advances in managing systemic sclerosis.
abstract: How the main components in systemic sclerosis-namely autoimmunity, vasculopathy, and fibrosis-fit together is still not sufficiently clear. However, vascular treatment options are well established, the body of evidence for the efficacy of immunomodulatory approaches is increasing, and now at least one hopeful substance that may directly interfere with fibrosis is being tested. Although we still wait for important breakthroughs, there is grounds for hope that better therapeutic options will be available in the near future.
authors.affiliation: Division of Rheumatology, Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Aringer
authors.affiliation: Division of Rheumatology, Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Erler
keywords: ACE inhibitors; SSc; phosphodiesterase 5 blockers; scleroderma; systemic sclerosis