title: Meta-Analysis of Risk Association Between Interleukin-17A and F Gene Polymorphisms and Inflammatory Diseases.
abstract: This meta-analysis examined the relationship between IL-17A (rs2275913) and IL17F (rs763780 T/C) gene polymorphisms and the risk of inflammatory diseases, including periodontitis, rheumatoid arthritis (RA), and inflammatory bowel disease. PubMed, MEDLINE, EMBASE, Web of Science, and Elsevier Science Direct were searched, and odds ratios (ORs) with 95% confidence interval (CI) were calculated to estimate the strength of the association. A total of 25 studies comprising 7,474 cases and 10,628 controls were included. Significant associations were found between inflammatory diseases and IL-17A rs2275913 A versus G allele (OR = 1.197, P = 0.033) and the GA versus GG genotype in the codominant model (OR = 1.406, P = 0.036). Our findings suggested that individuals who carry the rs2275913 A allele or GA genotype have a 20% or 41%-increased risk of inflammatory diseases compared with subjects with the G allele or GG genotype, respectively. With respect to IL-17F rs763780, the C versus T allele (OR = 1.94; P = 0.040), the TC versus TT (OR = 1.39; P = 0.041), the CC versus TT (OR = 2.71; P = 0.003), as well as the TC + CC versus TT genotype (OR = 1.83; P = 0.032) were risk factors for RA. In summary, our pooled analysis indicated that the IL-17A (rs2275913) and IL17F (rs763780 T/C) increased the RA risk.
authors.affiliation: 1 Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences , Zahedan, Iran .|2 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences , Zahedan, Iran .
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Eskandari-Nasab
authors.affiliation: 3 Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences , Isfahan, Iran .
authors.forename: Mehdi
authors.initials: M
authors.lastname: Moghadampour
authors.affiliation: 4 Department of Statistics, School of Science, Amir Kabir University of Technology , Tehran, Iran .
authors.forename: Arezoo
authors.initials: A
authors.lastname: Tahmasebi
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000235:genetics*; D020381:Interleukin-17 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
keywords: inflammatory diseases; interleukin-17A and F; meta-analysis; periodontitis; rheumatoid arthritis and IBD