title: Localizing Age-Related Changes in Brain Structure Using Voxel-Based Morphometry.
abstract: Aim. We report the dynamic anatomical sequence of human cortical gray matter development from late childhood to young adults using VBM and ROI-based methods.Method. The structural MRI of 91 normal individuals ranging in age from 6 to 26 years was obtained and the GMV for each region was measured.Results. Our results showed that the earliest loss of GMV occurred in left olfactory, right precuneus, caudate, left putamen, pallidum, and left middle temporal gyrus. In addition, the trajectory of maturational and aging showed a linear decline in GMV on both cortical lobes and subcortical regions. The most loss of gray matter was observed in the parietal lobe and basal ganglia, whereas the less loss occurred in the temporal lobe and hippocampus, especially in the left middle temporal pole, which showed no decline until 26 years old. Moreover, the volumes of GM, WM, and CSF were also assessed for linear age effects, showing a significant linear decline in GM with age and a significant linear increase in both WM and CSF with age.Interpretation. Overall, our findings lend support to previous findings of the normal brain development of regional cortex, and they may help in understanding of neurodevelopmental disorders.
authors.affiliation: College of Psychology and Sociology, Shenzhen University, Shenzhen 518060, China.
authors.forename: Shu Hua
authors.initials: SH
authors.lastname: Mu
authors.affiliation: Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518057, China.
authors.forename: Min
authors.identifier: 0000-0002-2325-3532
authors.initials: M
authors.lastname: Xu
authors.affiliation: College of Psychology and Sociology, Shenzhen University, Shenzhen 518060, China.
authors.forename: Jun Xiu
authors.initials: JX
authors.lastname: Duan
authors.affiliation: Shenzhen University Health Science Center, Shenzhen, China.
authors.forename: Jian
authors.identifier: 0000-0003-0732-1977
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518057, China.
authors.forename: Li Hai
authors.identifier: 0000-0001-6983-1767
authors.initials: LH
authors.lastname: Tan
mesh_terms: D000328:Adult; D000367:Age Factors; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D066128:Gray Matter / Q000166:cytology / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010775:Photic Stimulation; D014793:Visual Cortex / Q000166:cytology* / Q000502:physiology*; D055815:Young Adult