title: IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer.
abstract: Recent studies explored the association between insulin receptor substrate-2 (IRS-2) gene rs1805097 polymorphism and colorectal cancer (CRC) with contradictory findings. Therefore, we conducted a comprehensive meta-analysis by searching the databases of PubMed and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 5 citations containing 6 case-control studies involving 4,333 cases and 5,333 controls were included. Our data indicated that IRS-2 rs1805097 polymorphism was associated with decreased risk of CRC. Stratification analysis of ethnicity found that rs1805097 polymorphism decreased the risk of CRC among Americans. Stratification analysis of cancer type suggested that this polymorphism decreased the risk of colon cancer. In summary, this meta-analysis indicates that IRS-2 gene rs1805097 polymorphism plays an important role in the pathogenesis of CRC.
authors.affiliation: General Surgery Department, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
authors.forename: Jiefeng
authors.initials: J
authors.lastname: Yin
authors.affiliation: General Surgery Department, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Digestion, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
authors.forename: Huajun
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Digestion, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
mesh_terms: D000483:Alleles; D015179:Colorectal Neoplasms / Q000235:genetics*; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: C526297:IRS2 protein, human; D055504:Insulin Receptor Substrate Proteins
keywords: IRS-2; colorectal cancer; meta-analysis; rs1805097; single nucleotide polymorphism