title: Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine.
abstract: Intestinal epithelial cell polarity is instrumental to maintain epithelial homeostasis and balance communications between the gut lumen and bodily tissue, thereby controlling the defense against gastrointestinal pathogens and maintenance of immune tolerance to commensal bacteria. In this review, we highlight recent advances with regard to the molecular mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the human intestine.
authors.affiliation: Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
authors.forename: Leon J
authors.initials: LJ
authors.lastname: Klunder
authors.affiliation: Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
authors.forename: Klaas Nico
authors.initials: KN
authors.lastname: Faber
authors.affiliation: Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
authors.forename: Gerard
authors.initials: G
authors.lastname: Dijkstra
authors.affiliation: Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
authors.forename: Sven C D
authors.initials: SCD
authors.lastname: van IJzendoorn
mesh_terms: D016764:Cell Polarity; D004847:Epithelial Cells; D006706:Homeostasis; D007113:Immunity, Innate; D007422:Intestines / Q000166:cytology* / Q000276:immunology; D008871:Microvilli / Q000276:immunology; D008962:Models, Theoretical