title: Influence of age and cognitive performance on resting-state brain networks of older adults in a population-based cohort.
abstract: Aging leads to global changes in brain structure and cognitive performance, with reorganization of functional brain networks. Importantly, these age-related changes show higher inter-individual variability in older subjects. To particularly address this variability is a challenge for studies on lifetime trajectories from early to late adulthood. The present study therefore had a dedicated focus on late adulthood to characterize the functional connectivity in resting-state networks (RSFC) in relation to age and cognitive performance in 711 older adults (55-85 years) from the 1000BRAINS project. The executive, left and right frontoparietal resting-state (RS) networks showed age-related increases in RSFC. However, older adults did not show changes in RSFC in the default mode network (DMN). Furthermore, lower performance in working memory (WM) was associated with higher RSFC in the left frontoparietal RS network. The results suggest age-related compensatory increases in RSFC which might help to maintain cognitive performance. Nevertheless, the negative correlation between RSFC and WM performance hints at limited cognitive reserve capacity in lower performing older adults. Consequently, the current results provide evidence for a functional reorganization of the brain until late adulthood that might additionally explain parts of the variability of cognitive abilities in older adults.
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Jockwitz
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany. Electronic address: svenja.caspers@hhu.de.
authors.forename: Svenja
authors.initials: S
authors.lastname: Caspers
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Lux
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Institute Clinical Neuroscience and Medical Psychology, University of Düsseldorf, Düsseldorf, Germany; Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Jütten
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Lenzen
authors.affiliation: Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.affiliation: Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
authors.forename: Noreen
authors.initials: N
authors.lastname: Pundt
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
authors.forename: Andrew
authors.initials: A
authors.lastname: Reid
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Institute Clinical Neuroscience and Medical Psychology, University of Düsseldorf, Düsseldorf, Germany; Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Hoffstaedter
authors.affiliation: Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Jöckel
authors.affiliation: Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany; Division of Medical Genetics, University Hospital Basel, Basel, Switzerland.
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.affiliation: Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany; Department of Neurology, RWTH Aachen University, Aachen, Germany.
authors.forename: N Jon
authors.initials: NJ
authors.lastname: Shah
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.affiliation: Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology; D001288:Attention / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000502:physiology*; D009483:Neuropsychological Tests; D012146:Rest / Q000502:physiology
keywords: Aging; Cognition; Functional connectivity; ICA; Resting state