title: The association between interleukin-19 concentration and diabetic nephropathy.
abstract: BACKGROUND
  Interleukin-19 (IL-19) is a newly discovered cytokine belonging to the Interleukin-10(IL-10) family. IL-19 have indispensable functions in many inflammatory processes and also can induce the angiogenic potential of endothelial cells. The purpose of present study was to investigate the relation of serum interleukin-19 (IL-19) levels with diabetic nephropathy (DN).
  
  
  METHODS
  Two hundred study groups of patients with type 2 diabetes mellitus (T2DM) (109 males and 91 females) were recruited, included normoalbuminuria(n = 102), microalbuminuria(n = 72) and macroalbuminuria(n = 26) . The 50 healthy blood donors were enrolled for the control group. All subjects were assessed for: IL-19, High-sensitivity C-reactive protein (Hs-CRP), Cystatin C, urinary albumin excretion rate (UAE) and glycosylated hemoglobin A1c(HbA1c).
  
  
  RESULTS
  The serum IL-19 levels in DN patients were found to be significantly higher compared to controls. IL-19 levels were significantly positively correlated with Hs-CRP, Cystatin C, UAE and HbA1c(r = 0.623, 0.611,0.591 and 0.526 respectively, P < 0.01). Multivariable logistic regression analysis showed IL-19 levels (P = 0.01) were found to be independently associated with patients with DN.
  
  
  CONCLUSIONS
  IL-19 is significantly positive correlated with UAE and Cystatin C. IL-19 may play an important role that contributes to the progression of diabetic nephropathy.
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China. bhxylili@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: School of Medicine, Jiangsu University, Zhenjiang, China.
authors.forename: Xu-Gan
authors.initials: XG
authors.lastname: Jiang
authors.affiliation: Department of Clinical Laboratory, Binhai County Second Hospital, Binhai, Jiangsu Province, China.
authors.forename: Juan-Yu
authors.initials: JY
authors.lastname: Hu
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: ZHeng-Qing
authors.initials: ZQ
authors.lastname: Yu
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Xu
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Guang-Chun
authors.initials: GC
authors.lastname: Zhao
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Gu
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Si-Jing
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Meng
mesh_terms: D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; C421250:IL19 protein, human; D007378:Interleukins
keywords: Albuminuria; Diabetic nephropathy; High-sensitivity C-reactive protein; Interleukin-19