title: The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma.
abstract: Background.The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC). Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator. P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member which can mediate carcinogenesis through intracellular signaling.Methods.To assess their prognostic role; NEDD9 and p38 protein were evaluated in sections from 50 paraffin blocks of TCC.Results.The high expressions of NEDD9 and p38 protein were significantly associated with grade, stage, distant metastasis (p< 0.001), number of tumors, lymph node metastasis, and tumor size (p< 0.001, 0.002; 0.018, <0.001; and 0.004, 0.007, respectively). High NEDD9 and p38 detection had a worse 3-year OS (p= 0.041 and <0.001, respectively). By multivariate analysis the NEDD9 and p38 protein expression levels and various clinicopathological criteria including gender, grade, stage of the tumor, and regional lymph node involvement were independent prognostic parameters of TCC of the urinary bladder patients' outcome.Conclusion.NEDD9 and p38 protein expressions were poor prognostic markers of TCC.
authors.affiliation: Department of Pathology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Ola A
authors.identifier: 0000-0002-4396-3101
authors.initials: OA
authors.lastname: Harb
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Rasha
authors.identifier: 0000-0002-4319-375X
authors.initials: R
authors.lastname: Haggag
authors.affiliation: Department of Urology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Maged M
authors.initials: MM
authors.lastname: Ali
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Shereen
authors.initials: S
authors.lastname: El Shorbagy
authors.affiliation: Department of Pathology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Abeer M
authors.initials: AM
authors.lastname: Abdelbary
authors.affiliation: Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Lobna A
authors.initials: LA
authors.lastname: Abdelaziz
authors.affiliation: Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Reham A
authors.initials: RA
authors.lastname: Salim
authors.affiliation: Department of Urology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
authors.forename: Khaled M
authors.initials: KM
authors.lastname: Abdel Wahab