title: Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays.
abstract: Risk stratification of patients with early stage breast cancer may support adjuvant chemotherapy decision-making. This review details the development and validation of six multi-gene classifiers, each of which claims to provide useful prognostic and possibly predictive information for early stage breast cancer patients. A careful assessment is presented of each test's analytical validity, clinical validity, and clinical utility, as well as the quality of evidence supporting its use.
authors.affiliation: Desert Surgical Oncology, Eisenhower Medical Center, Rancho Mirage, California.
authors.forename: David M
authors.initials: DM
authors.lastname: Hyams
authors.affiliation: VMWA LLC, Palo Alto, California.
authors.forename: Eric
authors.initials: E
authors.lastname: Schuur
authors.affiliation: Instituto Nacional de Cancerología, Bogota, Colombia.
authors.forename: Javier
authors.initials: J
authors.lastname: Angel Aristizabal
authors.affiliation: Instituto Nacional de Cancerología, Mexico City, Mexico.
authors.forename: Juan Enrique
authors.initials: JE
authors.lastname: Bargallo Rocha
authors.affiliation: Universidade Estadual de Campinas, Campinas, Brazil.
authors.forename: Cesar
authors.initials: C
authors.lastname: Cabello
authors.affiliation: Hospital Dr. Ignacio Pirovano, Buenos Aires, Argentina.
authors.forename: Roberto
authors.initials: R
authors.lastname: Elizalde
authors.affiliation: Centro Integral Oncológico Comprensivo Clara Campal, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: García-Estévez
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
authors.forename: Henry L
authors.initials: HL
authors.lastname: Gomez
authors.affiliation: Hospital Sírio-Libanes, Sao Paulo, Brazil.
authors.forename: Artur
authors.initials: A
authors.lastname: Katz
authors.affiliation: Hospital Dr. Juan A. Fernandez, Buenos Aires, Argentina.
authors.forename: Aníbal
authors.initials: A
authors.lastname: Nuñez De Pierro
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results
keywords: adjuvant; biomarkers; breast neoplasms; chemotherapy; clinical decision-making; gene expression; genomics risk; prognosis; tumor