title: How Should Oxygen Supplementation Be Guided by Pulse Oximetry in Children: Do We Know the Level?
abstract: Supplemental oxygen is one of the most commonly prescribed therapies to children in hospital, but one of the least studied therapeutics. This review considers oxygen from a range of perspectives; discovery and early use; estimation of oxygenation in the human body-both clinically and by medical device; the effects of illness on oxygen utilization; the cellular consequences of low oxygen; and finally, how clinical studies currently inform our approach to targeting supplementing oxygen in those with lower than normal oxygen saturation.
authors.affiliation: Department of Respiratory and Sleep Medicine, Royal Hospital for Sick Children , Edinburgh , UK.
authors.forename: Ross
authors.initials: R
authors.lastname: Langley
authors.affiliation: Department of Respiratory and Sleep Medicine, Royal Hospital for Sick Children , Edinburgh , UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Cunningham
keywords: hypoxemia; hypoxia; lower respiratory tract infection; oxygen; oxygen saturation