title: Is There a Threshold Value of Hemoglobin A1c That Predicts Risk of Infection Following Primary Total Hip Arthroplasty?
abstract: There remains little evidence to support a perioperative hemoglobin A1c (HbA1c) level that could serve as a threshold for a significantly increased risk of deep postoperative infection in patients with diabetes mellitus (DM) following total hip arthroplasty (THA).
  
  
  
  A national administrative database was queried for patients who underwent primary THA with DM. Patients with an HbA1clevel within 3 months of surgery were identified and were stratified based on HbA1clevel in 0.5 mg/dL increments. The incidence of deep infection requiring operative intervention within 1 year for each group was identified and a receiver operating characteristic (ROC) and area under the curve (AUC) analysis was performed to determine a threshold value of the HbA1c.
  
  
  
  A total of 7736 patients who underwent THA with a perioperative HbA1clevel were included. The rate of infection ranged from 0.7% to 5.9%. The inflection point of the ROC curve corresponded to an HbA1clevel between 7.0 and 7.5 mg/dL (P = .001, specificity = 69%, sensitivity = 47%). The AUC for the ROC was 0.68. Patients with an HbA1clevel of 7.5 mg/dL or greater had a significantly higher risk of deep infection compared to patients below this threshold (odds ratio, 2.6; 95% CI, 1.9-3.4; P < .0001).
  
  
  
  The risk of infection in patients with DM increases as the perioperative HbA1cincreases. However, in the present study, the HbA1cthreshold level calculated demonstrated low discrimination based on our AUC value, suggesting the HbA1ctest is poorly predictive of periprosthetic joint infection following THA in patients with DM.
authors.affiliation: Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, Virginia.
authors.forename: Jourdan M
authors.initials: JM
authors.lastname: Cancienne
authors.affiliation: Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, Virginia.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Werner
authors.affiliation: Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, Virginia.
authors.forename: James A
authors.initials: JA
authors.lastname: Browne
mesh_terms: D019540:Area Under Curve; D001170:Arthritis, Infectious / Q000097:blood / Q000209:etiology / Q000601:surgery; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015331:Cohort Studies; D016208:Databases, Factual; D048909:Diabetes Complications / Q000097:blood* / Q000601:surgery; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D015994:Incidence; D007348:Insurance, Health; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D016459:Prosthesis-Related Infections / Q000097:blood / Q000150:complications; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013530:Surgical Wound Infection / Q000097:blood* / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D006442:Glycated Hemoglobin
keywords: HbA(1c); diabetes; periprosthetic joint infection; threshold; total hip arthroplasty