title: Impact of rTMS on functional connectivity within the language network in schizophrenia patients with auditory hallucinations.
abstract: This exploratory study investigated the functional connectivity (FC) in the language network in schizophrenia patients (SZ) with auditory verbal hallucinations (AVHs), and the therapeutic efficacy of rTMS on it. Eleven SZ with AVHs and 10 healthy controls (HC) underwent two fMRI sessions using a speech listening paradigm. SZ received 20Hz rTMS following the first fMRI session. Compared to HC, SZ showed a reduced FC in the language network. While AVHs improved after 12days, no changes in FC were observed. This suggests the efficacy of high-frequency rTMS on AVH without any impact for rTMS on FC within the language network.
authors.affiliation: Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Normandie Univ, UNICAEN, Faculté de médecine, Caen F-14000, France.
authors.forename: F
authors.initials: F
authors.lastname: Briend
authors.affiliation: Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Normandie Univ, UNICAEN, Faculté de médecine, Caen F-14000, France.
authors.forename: E
authors.initials: E
authors.lastname: Leroux
authors.affiliation: Normandie Univ, UNICAEN, CNRS UMS 3408, GIP Cyceron, Caen F-14000, France.
authors.forename: N
authors.initials: N
authors.lastname: Delcroix
authors.affiliation: Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Normandie Univ, UNICAEN, Faculté de médecine, Caen F-14000, France.
authors.forename: A
authors.initials: A
authors.lastname: Razafimandimby
authors.affiliation: Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Normandie Univ, UNICAEN, Faculté de médecine, Caen F-14000, France; CHU de Caen, Service d'Explorations Fonctionnelles du Système Nerveux, Caen F-14000, France.
authors.forename: O
authors.initials: O
authors.lastname: Etard
authors.affiliation: Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Normandie Univ, UNICAEN, Faculté de médecine, Caen F-14000, France; CHU de Caen, Service de psychiatrie, Centre Esquirol, Caen F-14000, France. Electronic address: dollfus-s@chu-caen.fr.
authors.forename: S
authors.initials: S
authors.lastname: Dollfus
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006212:Hallucinations / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D012559:Schizophrenia / Q000150:complications* / Q000000981:diagnostic imaging*; D050781:Transcranial Magnetic Stimulation
chemical_list: D010100:Oxygen
keywords: Auditory verbal hallucination; Connectivity; Functional MRI; Language network; Schizophrenia; rTMS