title: C21steroidal glycosides and oligosaccharides from the root bark of Periploca sepium.
abstract: Four new C21steroidal glycosides (1-4), named perisepiumosides FI (1-4) together with six known steroidal glycosides (5-10) and four oligosaccharides (11-14), were isolated from the root bark of Periploca sepium. Their structures were characterized on the basis of 1D and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The evaluation of inhibition activity against human A-549 and HepG2 cell lines indicated that compounds 2, 8, 10 and 13 showed different levels of cytotoxic activities with IC50values ranging from 0.61 to 7.86μM.
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Xin-Yue
authors.initials: XY
authors.lastname: Gu
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zhou-Wei
authors.initials: ZW
authors.lastname: Wu
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Li
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610013, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: wangmk@cib.ac.cn.
authors.forename: Ming-Kui
authors.initials: MK
authors.lastname: Wang
mesh_terms: D000072283:A549 Cells; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry* / Q000302:isolation & purification; D031109:Periploca / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D006027:Glycosides; D009844:Oligosaccharides
keywords: C(21) steroidal glycosides; Cytotoxic activities; Oligosaccharides; Periploca sepium