title: Investigation and management of IgM and Waldenström-associated peripheral neuropathies: recommendations from the IWWM-8 consensus panel.
abstract: Paraproteinaemic neuropathies are a heterogeneous group of disorders most frequently associated with IgM monoclonal gammopathies including Waldenström macroglobulinaemia (WM). Their consequences are significant for affected patients, and their management challenging for their physicians. The variability in clinical presentation and time course hamper classification and management. The indications for invasive investigations such as cerebrospinal fluid analysis, nerve conduction tests and sensory nerve biopsies are unclear, and the optimum way to measure clinical response to treatment unknown. When to intervene and and how to treat, also present challenges to physicians. As part of its latest deliberations at the International Workshops on WM (IWWM) in London, UK (August 2014), the IWWM8 panel have proposed a consensus approach to the diagnosis and management of peripheral neuropathies associated with IgM monoclonal gammopathies, including WM. Importantly, a consensus regarding the use of clinical outcome measures and recommended models of care for this group of patients is discussed, as well as appropriate treatment interventions.
authors.affiliation: Waldenström Clinic, Cancer Division, University College London Hospitals NHS Foundation Trust, London, UK.
authors.forename: Shirley
authors.initials: S
authors.lastname: D'Sa
authors.affiliation: Department of Haematology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Marie José
authors.initials: MJ
authors.lastname: Kersten
authors.affiliation: Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
authors.affiliation: Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Meletios
authors.initials: M
authors.lastname: Dimopoulos
authors.affiliation: Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Efstathios
authors.initials: E
authors.lastname: Kastritis
authors.affiliation: Department of Haematology, North Estonia Medical Centre, Tallinn, Estonia.
authors.forename: Edward
authors.initials: E
authors.lastname: Laane
authors.affiliation: AP-HP Hôpital Pitié Salpêtrière, UPMC Univ. Paris 6 GRC-11, Grechy, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Leblond
authors.affiliation: Centre for Research and Treatment of Systemic Amyloidosis, University of Pavia, Pavia, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Merlini
authors.affiliation: Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Treon
authors.affiliation: Department of Haematology, Academic Medical Centre, Amsterdam, the Netherlands.|Cancer Centre, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands.
authors.forename: Josephine M
authors.initials: JM
authors.lastname: Vos
authors.affiliation: Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Lunn
mesh_terms: D006801:Humans; D007075:Immunoglobulin M; D010265:Paraproteinemias / Q000175:diagnosis* / Q000628:therapy*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000628:therapy; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis / Q000628:therapy
chemical_list: D007075:Immunoglobulin M
keywords: IgM; Waldenstrom macroglobulinaemia; paraproteinaemic neuropathy