title: Lithium response in bipolar disorder: No difference in GADL1 gene expression between cell lines from excellent-responders and non-responders.
abstract: Previous association studies have shown mixed results between glutamic acid decarboxylase like-1 (GADL1) gene polymorphism and prophylactic lithium response in bipolar disorder (BD) patients. In the present study, GADL1 gene expression was investigated in regard to lithium response, using Alda scale, in lymphoblastoid cells (LCLs) of 36 Caucasian BD patients. No difference in GADL1 expression was observed among LCLs from excellent-responders, non-responders or controls. Furthermore, lithium did not induce significant changes in GADL1 expression levels after 4 or 8 days. These results did not support an association of GADL1 expression in the determination of a lithium response in BD patients.
authors.affiliation: Inserm, U1144, Paris F-75006, France; Université Sorbonne Paris Cité, UMR-S 1144, Paris F-75006, France. Electronic address: jeverson.moreira@inserm.fr.
authors.forename: Jeverson
authors.initials: J
authors.lastname: Moreira
authors.affiliation: Inserm, U1144, Paris F-75006, France; Université Sorbonne Paris Cité, UMR-S 1144, Paris F-75006, France.
authors.forename: Cindie
authors.initials: C
authors.lastname: Courtin
authors.affiliation: Inserm, U1144, Paris F-75006, France; Université Sorbonne Paris Cité, UMR-S 1144, Paris F-75006, France; AP-HP, GH Saint-Louis - Lariboisière - F. Widal, Pôle de Psychiatrie et de Médecine Addictologique, 75475 Paris cedex 10, France; Fondation FondaMental, Créteil, 94000, France.
authors.forename: Pierre A
authors.initials: PA
authors.lastname: Geoffroy
authors.affiliation: Inserm, U1144, Paris F-75006, France; Université Sorbonne Paris Cité, UMR-S 1144, Paris F-75006, France; Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, APHP, Paris, France; Laboratoire de biomathématiques, plateau iB(2), Faculté de pharmacie de Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Curis
authors.affiliation: Inserm, U1144, Paris F-75006, France; Université Sorbonne Paris Cité, UMR-S 1144, Paris F-75006, France; AP-HP, GH Saint-Louis - Lariboisière - F. Widal, Pôle de Psychiatrie et de Médecine Addictologique, 75475 Paris cedex 10, France; Fondation FondaMental, Créteil, 94000, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier
authors.affiliation: Inserm, U1144, Paris F-75006, France; Université Sorbonne Paris Cité, UMR-S 1144, Paris F-75006, France. Electronic address: cynthia.marie-claire@parisdescartes.fr.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Marie-Claire
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000235:genetics*; D002262:Carboxy-Lyases / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D018020:Lithium Compounds / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016896:Treatment Outcome
chemical_list: D018692:Antimanic Agents; D018020:Lithium Compounds; D002262:Carboxy-Lyases; C585765:GADL1 protein, human
keywords: Biomarker; Mood disorder; Therapeutic response