title: Wound Healing Effect ofArnebia euchromagel on Excisional Wounds in Rats.
abstract: BACKGROUND
  Wound healing is a complex process leading to regeneration of damaged skin tissue.Arnebia euchroma(AE) have many effective activities such as anti-inflammatory, antimicrobial, antioxidative, and anti-tumoral effects. The extract of AE has positive effects on burn wounds. This study is designed to investigate the healing effects of AE on excisional wounds in rats.
  
  
  METHODS
  Thirty six rats with the age of 8 weeks divided into three groups. One group (E1) was treated with AE gel at a concentration of 10%. Control group (C1) received normal saline and the vehicle group (C2) was treated with carboxymethyl cellulose gel as the vehicle for 14 days. Stereological analysis was done to investigate the collagen bundle and hair follicale synthesis, vascularization, fibroblast proliferation. Pathological evaluation was also conducted.
  
  
  RESULTS
  In this study, pathological evaluation showed severe acute inflammation in C2 group, chronic and acute inflammation in C1 and also more wound contraction in E1 in comparison with other groups. There was a meaningful difference between E1 and C1 regarding fibroblast proliferation (P< 0.05).
  
  
  CONCLUSIONS
  Results of this study revealed the healing effect of AE on excisional wounds and recommend its administration after further clinical investigations.
authors.affiliation: Young Researchers and Elit Club, Tehran Medial Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mohsenikia
authors.affiliation: Department of Physiology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Khakpour
authors.affiliation: Department of Dermatology, Dermatological Research Center, Rasul Akram Dermatological Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Azizian
authors.affiliation: Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Soheil
authors.initials: S
authors.lastname: Ashkani-Esfahani
authors.affiliation: Payam Noor University, Shiraz Branch, Shiraz, Iran.
authors.forename: Seyyede Tahereh
authors.initials: ST
authors.lastname: Razavipour
authors.affiliation: Islamic Azad University, Shahrekord Branch, Shahrekord, Iran.
authors.forename: Pooya
authors.initials: P
authors.lastname: Toghiani
keywords: Arnebia euchroma; excisional wound; healing; skin