title: Impact ofKelussia odoratissimaMozaffarian lipid profile and fasting blood sugar in hyperlipidemia patients.
abstract: Introduction:Hyperlipidemia is associated with increased risk of cardiovascular disease. Each type of medication works differently and has different types of side effects. Flavonoids are a group of polyphenolic compounds with antioxidant properties that help reducing the cardiovascular risk factors.Kelussia odoratissimais a flavonoid containing plant.Objectives:The aim of this study was investigating the effect of this herb on lipid and glucose profile in hyperlipidemia patients.
  
  
  METHODS
  This study performed on 61 hyperlipidemia patients. They assigned in control and intervention groups. The control group received 40 mg/day of lovastatin and intervention group received 40 mg/day of Lovastatin plus 2 g/day powder ofKelussia odoratissima. Before, two weeks and 1 month after the beginning of the study, cholesterol, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), and fasting blood sugar (FBS) were measured. Data were analyzed by variance analysis with repeated measures, chi-square and t tests.Results:The reduction rate of cholesterol, TG, VLDL-C and LDL-C was similar in the control and intervention groups. The HDL-C rate was higher in intervention group compared to control group (P< 0.05). The mean LDL/HDL ratio decreased during the study (P< 0.001); however, there was not any significant difference between the two groups (P> 0.05). The mean of FBS did not change between and within groups (P> 0.05).Conclusion:Kelussia odoratissimadid not have a desirable effect on serum lipid profile and FBS in hyperlipidemic patients that use lovastatin, but is able to increase HDL-C significantly.
authors.affiliation: Nutrition and Food Science School, Isfahan University of Medical of Sciences, Isfahan, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Kafeshani
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mirhosseini
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Momeni
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Rahmatollah
authors.initials: R
authors.lastname: Rabiei
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
keywords:  Kelussia odoratissima ; Cholesterol; Human; Hyperlipidemia; Triglyceride