title: Noncoronary Vascular Calcification, Bone Mineral Density, and Muscle Mass in Institutionalized Frail Nonagenarians.
abstract: The purpose of this study was to compare the vascular calcification in thoracic aorta (TAC), abdominal aorta (AAC), iliac arteries (IAC), and femoral arteries (FAC) and bone mineral density (BMD) of the lumbar vertebrae between frail and robust nonagenarians, as well as to verify the associations between vascular calcification with BMD, muscle tissue quality, and quantity in both groups. Forty-two elderly subjects participated in this study: 29 institutionalized frail (92.0 ± 3.2 years) and 13 robust (89.0 ± 4.0 years) elderly participants. All patients underwent nonenhanced helical thoracic, abdominal, and thigh computed tomography. The frail group presented significantly greater FAC as well as less lumbar BMD than the robust group (p < 0.05). In the frail group, significant negative relationships were observed between the individual values of FAC with the individual values of BMD (r = -0.35 to -0.43, p < 0.05) and with the individual values of the quadriceps muscle quantity and quality (r = -0.52, p < 0.01), whereas no significant relationships were observed in the robust group. The robust group presented less vascular calcification and more BMD in the vertebral bodies than the frail group. In the frail group, femoral artery calcification was significantly negatively correlated with BMD, leg muscle quality, and muscle mass volume.
authors.affiliation: 1 Department of Radiology, Clínica San Miguel , Pamplona, Spain .
authors.forename: Fernando
authors.initials: F
authors.lastname: Idoate
authors.affiliation: 2 Exercise Research Laboratory, Federal University of Rio Grande do Sul , Porto Alegre, Brazil .
authors.forename: Eduardo L
authors.initials: EL
authors.lastname: Cadore
authors.affiliation: 3 Division of Geriatric Medicine, Complejo Hospitalario de Navarra , CIBER de Fragilidad y Envejecimiento Saludable (CB16/10/00315) Pamplona, Navarra, Spain .
authors.forename: Alvaro
authors.initials: A
authors.lastname: Casas-Herrero
authors.affiliation: 4 Department of Health Sciences, Public University of Navarre , CIBER de Fragilidad y Envejecimiento Saludable (CB16/10/00315), Tudela, Navarre, Spain .
authors.forename: Fabricio
authors.initials: F
authors.lastname: Zambom-Ferraresi
authors.affiliation: 3 Division of Geriatric Medicine, Complejo Hospitalario de Navarra , CIBER de Fragilidad y Envejecimiento Saludable (CB16/10/00315) Pamplona, Navarra, Spain .
authors.forename: Nicolas
authors.initials: N
authors.lastname: Martínez-Velilla
authors.affiliation: 5 Division of Geriatric Medicine, University Hospital of Getafe , CIBER de Fragilidad y Envejecimiento Saludable (CB16/10/00464), Madrid, Spain .
authors.forename: Leocadio
authors.initials: L
authors.lastname: Rodriguez-Mañas
authors.affiliation: 6 Hospital San Pedro , Riojasalud, Logroño, La Rioja, Spain .
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Azcárate
authors.affiliation: 7 College of Physical Education, University of Brasília , Brasília, Brazil .
authors.forename: Martim
authors.initials: M
authors.lastname: Bottaro
authors.affiliation: 8 Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario , Bogotá, Colombia .
authors.forename: Robinson
authors.initials: R
authors.lastname: Ramírez-Vélez
authors.affiliation: 4 Department of Health Sciences, Public University of Navarre , CIBER de Fragilidad y Envejecimiento Saludable (CB16/10/00315), Tudela, Navarre, Spain .
authors.forename: Mikel
authors.initials: M
authors.lastname: Izquierdo
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology; D000369:Aged, 80 and over; D015519:Bone Density; D002118:Calcium / Q000378:metabolism; D003710:Demography; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000033:anatomy & histology*; D009929:Organ Size; D013131:Spine / Q000502:physiology; D013848:Thigh / Q000033:anatomy & histology; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification
chemical_list: D002118:Calcium
keywords: bone mineral density; frailty; muscle fat infiltration; muscle quality; vascular calcification