title: Multifunctional magnetic co-delivery system coated with polymer mPEG-PLL-FA for nasopharyngeal cancer targeted therapy and MR imaging.
abstract: The gene and drug co-delivery system has become one of the primary strategies to overcome cancers. Here, we designed a multifunctional magnetic co-delivery system for nasopharyngeal carcinoma-targeted therapy and MR imaging. Aldehyde sodium alginate (ASA) was used to decorate the oxide iron and load cisplain through coordinate bond to form a core complex. The polymer shell poly(l-lysine)-methoxy-polyethylene glycol-folate was used to coat the core complex through electric interaction to give this nano-medicine a target ability. And this polymer could also give the nano-medicine abilities to adhere and protect DNA, and enhance its solubleness in water. After being transfected with this nano-medicine, the plasmids which contain cancer suppressor gene TFPI2 could enter and express in HNE-1 cells. It caused a higher death and apoptosis rate, inhibited nasopharyngeal carcinoma cells' migration and cloning by the synergic effect together with cisplain. Besides, clear images of this nano-medicine could be got under T2 MR imaging. This magnetic co-delivery system demonstrates a potential as a powerful multifunctional vector for drug delivery and gene vector applications in nasopharyngeal carcinoma.
authors.affiliation: 1 Department of Otorhinolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Hailiang
authors.initials: H
authors.lastname: Li
authors.affiliation: 2 Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China.
authors.forename: Chaoping
authors.initials: C
authors.lastname: Fu
authors.affiliation: 1 Department of Otorhinolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Xiangwan
authors.initials: X
authors.lastname: Miao
authors.affiliation: 1 Department of Otorhinolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Quanming
authors.initials: Q
authors.lastname: Li
authors.affiliation: 1 Department of Otorhinolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: 3 Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Huikang
authors.initials: H
authors.lastname: Yang
authors.affiliation: 1 Department of Otorhinolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: 4 Department of Anaesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: 1 Department of Otorhinolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Minqiang
authors.initials: M
authors.lastname: Xie
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy*; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D003287:Contrast Media / Q000008:administration & dosage; D005492:Folic Acid / Q000737:chemistry / Q000493:pharmacokinetics*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D058990:Molecular Targeted Therapy / Q000379:methods; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy*; D010957:Plasmids / Q000008:administration & dosage / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; C117924:mPEG-block-PLL; D011107:Polylysine; D011092:Polyethylene Glycols; D005492:Folic Acid
keywords: MR imaging; Nasopharyngeal carcinoma; cisplatin; co-delivery system; gene therapy; magnetic nano-medicine; molecular targeting