title: Genetic and phylogenetic analysis of feline calicivirus isolates in China.
abstract: The aim of this study was to determine the genetic diversity of Chinese feline calicivirus (FCV) isolates and their phylogenetic relationship with isolates from elsewhere in the world. Phylogenetic analysis was performed based on the partial open reading frame (ORF) 2 sequences (regions B-F) of 21 Chinese FCV isolates and 30 global isolates. The Chinese isolates included 13 isolates from Wuhan, which were isolated in this study, and eight previously published isolates. Sixteen Chinese isolates and two Japanese isolates formed a distinct phylogenetic cluster. Phylogenetic analysis based on the sequences of the complete genome, ORF1, ORF2 and ORF3 of selected isolates supported the above findings. Genogroup analysis revealed that FCV genogroup II is present in China. These findings suggest that Chinese FCV isolates are closely related to Japanese FCV isolates.
authors.affiliation: Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Deng
authors.affiliation: Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Ruiming
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Huanchun
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: wub@mail.hzau.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000662:veterinary* / Q000821:virology; D017927:Calicivirus, Feline / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D002371:Cat Diseases / Q000821:virology*; D002415:Cats; D002681:China; D014644:Genetic Variation; D010802:Phylogeny; D017423:Sequence Analysis, RNA / Q000662:veterinary
chemical_list: D036022:Capsid Proteins
keywords: China; Feline calicivirus; Genogroup; ORF2; Phylogenetic relationship