title: Circular RNAs in Cardiovascular Disease: An Overview.
abstract: Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Ximin
authors.identifier: 0000-0003-1154-6861
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Weng
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Heart Failure Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Gan
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Dachun
authors.identifier: 0000-0002-3910-3192
authors.initials: D
authors.lastname: Xu
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D012313:RNA / Q000096:biosynthesis / Q000235:genetics*; D012326:RNA Splicing / Q000235:genetics; D000079962:RNA, Circular
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D000079962:RNA, Circular; D012313:RNA