title: SkinSensDB: a curated database for skin sensitization assays.
abstract: Skin sensitization is an important toxicological endpoint for chemical hazard determination and safety assessment. Prediction of chemical skin sensitizer had traditionally relied on data from rodent models. The development of the adverse outcome pathway (AOP) and associated alternative in vitro assays have reshaped the assessment of skin sensitizers. The integration of multiple assays as key events in the AOP has been shown to have improved prediction performance. Current computational models to predict skin sensitization mainly based on in vivo assays without incorporating alternative in vitro assays. However, there are few freely available databases integrating both the in vivo and the in vitro skin sensitization assays for development of AOP-based skin sensitization prediction models. To facilitate the development of AOP-based prediction models, a skin sensitization database named SkinSensDB has been constructed by curating data from published AOP-related assays. In addition to providing datasets for developing computational models, SkinSensDB is equipped with browsing and search tools which enable the assessment of new compounds for their skin sensitization potentials based on data from structurally similar compounds. SkinSensDB is publicly available at http://cwtung.kmu.edu.tw/skinsensdb.
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, 80708 Taiwan.|PhD Program in Toxicology, Kaohsiung Medical University, Kaohsiung, 80708 Taiwan.|National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County, 35053 Taiwan.|Institute of Environmental Engineering, National Sun Yat-sen University, Kaohsiung, 80424 Taiwan.
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, 80708 Taiwan.|PhD Program in Toxicology, Kaohsiung Medical University, Kaohsiung, 80708 Taiwan.
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Lin
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, 80708 Taiwan.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, 80708 Taiwan.
authors.forename: Chieh
authors.initials: C
authors.lastname: Shih
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, 80708 Taiwan.
authors.forename: Yi-Hui
authors.initials: YH
authors.lastname: Lin
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, 80708 Taiwan.|PhD Program in Toxicology, Kaohsiung Medical University, Kaohsiung, 80708 Taiwan.|National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County, 35053 Taiwan.|Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 80708 Taiwan.
authors.forename: Chun-Wei
authors.identifier: 0000-0003-3011-8440
authors.initials: CW
authors.lastname: Tung