title: Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits.
abstract: Potassium homeostasis has a very high priority because of its importance for membrane potential. Although extracellular K+is only 2% of total body K+, our physiology was evolutionarily tuned for a high-K+, low-Na+diet. We review how multiple systems interface to accomplish fine K+balance and the consequences for health and disease.
authors.affiliation: Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California; and mcdonoug@usc.edu.
authors.forename: Alicia A
authors.initials: AA
authors.lastname: McDonough
authors.affiliation: Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Jang H
authors.initials: JH
authors.lastname: Youn
mesh_terms: D000222:Adaptation, Physiological; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D002319:Cardiovascular System; D000072001:Diet, Healthy; D004435:Eating; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008564:Membrane Potentials; D018482:Muscle, Skeletal / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D017419:Potassium, Dietary / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D012982:Sodium, Dietary
chemical_list: D017419:Potassium, Dietary; D012982:Sodium, Dietary; D000450:Aldosterone; D012964:Sodium; D011188:Potassium