title: Methylmercury exposure and cognitive abilities and behavior at 10years of age.
abstract: Methylmercury (MeHg) is a known developmental neurotoxicant present in fish, yet the impact of childhood exposure is uncertain, especially in children with poor nutrition.
  
  
  
  To evaluate associations of MeHg exposure with cognitive abilities and behavior in children from a poor rural area in Bangladesh.
  
  
  
  The MeHg exposure was assessed in 1434 ten-year-old children by measuring mercury concentrations in hair (hair-Hg), using inductively coupled plasma mass spectrometry. Cognitive abilities were assessed with the Wechsler Intelligence Scale for Children (4th edition), and behavior by the parent-report Strengths and Difficulties Questionnaire.
  
  
  
  Children's median hair-Hg was 674μg/kg (range 70-17,561μg/kg). Concentrations did not differ by distance from scalp, indicating a similar exposure over time. No multivariable-adjusted associations were observed between the children's hair-Hg and their cognitive abilities. However, children in the highest tertile of hair-Hg had a lower prevalence of hyperactivity (OR: 0.61, 95% CI: 0.45-0.83) and peer relationship problems (OR: 0.58, 95% CI: 0.44-0.76), compared to children in the lowest tertile. The corresponding ORs were slightly stronger in children from families with lower socioeconomic status (OR: 0.56, 95% CI: 0.34-0.90 and OR: 0.48, 95% CI: 0.30-0.74) than in children from families with higher socioeconomic status (OR: 0.73, 95% CI: 0.49-1.08 and OR: 0.72, 95% CI: 0.51-1.02). Similar stronger ORs were observed in underweight children.
  
  
  
  MeHg exposure was not associated with cognitive function, but inversely associated with certain adverse behavior. More studies are needed concerning the risk-benefit of different fish consumption in rural Bangladesh.
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.
authors.forename: Klara
authors.initials: K
authors.lastname: Gustin
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
authors.forename: Fahmida
authors.initials: F
authors.lastname: Tofail
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
authors.forename: Fardina
authors.initials: F
authors.lastname: Mehrin
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Levi
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Vahter
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. Electronic address: Maria.Kippler@ki.se.
authors.forename: Maria
authors.initials: M
authors.lastname: Kippler
mesh_terms: D000818:Animals; D001459:Bangladesh; D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D005399:Fishes / Q000378:metabolism; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008297:Male; D008767:Methylmercury Compounds / Q000032:analysis* / Q000633:toxicity; D018570:Risk Assessment; D012424:Rural Population; D012923:Social Class; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000633:toxicity; D014888:Wechsler Scales
chemical_list: D008767:Methylmercury Compounds; D014874:Water Pollutants, Chemical
keywords: Behavior; Fish pollutant; Hair; Methylmercury; Neurodevelopment; Risk-benefit