title: Intraprostatic ozone therapy: A minimally invasive approach in benign prostatic hyperplasia.
abstract: BACKGROUND
  Transurethral resection of prostate (TURP) remains the golden standard therapy since decades. There are various minimally invasive therapies (MITs) for the treatment of benign prostatic hyperplasia (BPH). Still, there is a need for therapy with lesser side effects and better outcome. We had studied the effect of intraprostatic ozone injection (IPOI) as an MIT for patients with BPH who have failed trial without catheter (TWOC).
  
  
  METHODS
  Thirty elderly patients with BPH with a prostate size of 30 g or more were enrolled for the study. Forty milliliters of ozone at a concentration of 30 μg/dl was injected in prostate (20 ml in each lateral lobe) per rectally. Prostate volume (PV) by ultrasonography was assessed after catheter removal on the 7thday and after 1 month.
  
  
  RESULTS
  Totally thirty patients (mean age - 67.8 years) with mean prostatic volume (MPV) of 46.10cc received IPOI. MPV came as 44.96cc on the 7thday of postozone therapy (P= 0.008). Successful voiders showed a significant reduction in PV (mean = 13.12cc) as compared to unsuccessful voiders (mean = 2.61cc) after 1 month.
  
  
  CONCLUSIONS
  Intraprostatic ozone injection helps to reduce the PV to some extent and can be helpful in patients who have failed TWOC even on alpha blockers and are unfit for TURP. Larger studies are required to assess the efficacy and long-term results of this technique.
authors.affiliation: Department of Surgery, NSCB Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Shabbir
authors.initials: S
authors.lastname: Hussain
authors.affiliation: Department of Surgery, NSCB Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Deepti B
authors.initials: DB
authors.lastname: Sharma
authors.affiliation: Department of Surgery, NSCB Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Fanindra S
authors.initials: FS
authors.lastname: Solanki
authors.affiliation: Department of Surgery, NSCB Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Pathak
authors.affiliation: Department of Surgery, NSCB Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Sharma
keywords: Benign prostatic hyperplasia; intraprostatic ozone therapy; minimally invasive