title: Adult ocular medulloepithelioma diagnosed by transscleral fine needle aspiration: A case report.
abstract: Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years-old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed of two distinctive populations of cells. The first consisted of epithelioid large cohesive cells with rare rosettes. Nuclei were oval and chromatin was delicate with small nucleoli. The second population consisted of smaller and dispersed cells with regular nuclei and dusty chromatin. Immunohistochemistry performed on paraffin-embedded cell block sections showed that the larger cells and rosettes were cytokeratin AE1/AE3, Synaptophysin, Chromogranin A, CD56, NSE, and EMA positive, whereas the smaller cells were always negative. Interestingly smaller cells expressed only weak nuclear positivity for TTF1, whereas larger cells were TTF1 negative. Melanocytic markers were negative in both populations. Morphological patterns and immunohistochemical staining confirmed ocular ME and allowed to exclude pulmonary metastasis or primary malignant melanoma. The patient was successfully treated by brachytherapy alone and is alive and well 10 months after treatment. Diagn. Cytopathol. 2017;45:561-564. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Ophtalmology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Amir
authors.initials: A
authors.lastname: Mahdjoubi
authors.affiliation: Department of Ophtalmology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Cassoux
authors.affiliation: Department of Ophtalmology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Levy-Gabriel
authors.affiliation: Department of Ophtalmology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Desjardins
authors.affiliation: Department of Pathology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Jan
authors.initials: J
authors.lastname: Klos
authors.affiliation: Department of Pathology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Martial
authors.initials: M
authors.lastname: Caly
authors.affiliation: Department of Pathology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Vlajnic
authors.affiliation: Department of Pathology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Gardrat
authors.affiliation: Department of Pathology, Institut Curie 26, Rue d'Ulm, 75248, Paris Cedex, France.
authors.forename: Jerzy
authors.identifier: http://orcid.org/0000-0001-9706-7241
authors.initials: J
authors.lastname: Klijanienko
mesh_terms: D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods; D005134:Eye Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology*
keywords: adult; brachytherapy; fine needle aspiration; intraocular tumor; medulloepithelioma; transscleral aspiration