title: Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia.
abstract: An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77% yield and 62 : 38 dr.
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering East China Normal University, 3663 North Zhongshan Rd., Shanghai 200062, China. whu@chem.ecnu.edu.cn.
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Ma
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering East China Normal University, 3663 North Zhongshan Rd., Shanghai 200062, China. whu@chem.ecnu.edu.cn.
authors.forename: Jianghui
authors.initials: J
authors.lastname: Chen
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering East China Normal University, 3663 North Zhongshan Rd., Shanghai 200062, China. whu@chem.ecnu.edu.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: Xing
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering East China Normal University, 3663 North Zhongshan Rd., Shanghai 200062, China. whu@chem.ecnu.edu.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering East China Normal University, 3663 North Zhongshan Rd., Shanghai 200062, China. whu@chem.ecnu.edu.cn.
authors.forename: Wenhao
authors.identifier: http://orcid.org/0000-0001-5143-7534
authors.initials: W
authors.lastname: Hu