title: The Mitochondrial Ca2+Uniporter: Structure, Function, and Pharmacology.
abstract: Mitochondrial Ca2+uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+uptake and our current understanding of mitochondrial Ca2+homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+uniporter complex.
authors.affiliation: Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Mishra
authors.affiliation: Cardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
authors.forename: Bong Sook
authors.initials: BS
authors.lastname: Jhun
authors.affiliation: Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hurst
authors.affiliation: Cardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA. jin.ouchi@lifespan.org.
authors.forename: Jin
authors.initials: J
authors.lastname: O-Uchi
authors.affiliation: MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA. Gyorgy.Csordas@jefferson.edu.
authors.forename: György
authors.initials: G
authors.lastname: Csordás
authors.affiliation: Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA. shey-shing.sheu@jefferson.edu.
authors.forename: Shey-Shing
authors.initials: SS
authors.lastname: Sheu
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism
chemical_list: D015220:Calcium Channels; C034703:mitochondrial calcium uniporter; D002118:Calcium
keywords: Mitochondria; Mitochondrial Ca2+ uniporter; Mitochondrial Ca2+ uptake; Pharmacology