title: Advances in mechanisms and management of chronic cough: The Ninth London International Cough Symposium 2016.
abstract: At the Ninth London International Cough Symposium held in June 2016, advances in chronic cough were presented. Chronic cough has been labelled as a cough hypersensitivity syndrome (CHS) with neuroinflammatory mechanisms likely to be the underlying mechanisms. The concept is that there is a stage of peripheral sensitisation induced by inflammatory factors setting up the scene for a central component that can be visualised by functional magnetic resonance imaging. There has also been progress in assessing CHS patients in the clinic in terms of measuring cough, with an increasing interest in assessing different types of cough associated with respiratory diseases such as asthma, COPD, bronchiectasis and pulmonary fibrosis. There is an emerging area of new antitussives in the form of neuromodulators. These advances have been paralleled by improvements in the management of patients with chronic cough. However, more work is needed but the future looks promising.
authors.affiliation: National Heart & Lung Institute, Imperial College London, UK; Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK. Electronic address: f.chung@imperial.ac.uk.
authors.forename: Kian Fan
authors.initials: KF
authors.lastname: Chung
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D003371:Cough / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D012140:Respiratory Tract Diseases / Q000188:drug therapy* / Q000503:physiopathology; D013577:Syndrome
chemical_list: D000996:Antitussive Agents