title: [Remodeling of the aging heart : Sinus node dysfunction and atrial fibrillation].
abstract: The incidence of both sinus node dysfunction (SND) and atrial fibrillation (AF) increases with age. SND and AF frequently coexist. Likewise, they are often associated with cardiovascular diseases. Both arrhythmias share similar pathomechanisms such as structural and functional remodeling, i. e., degenerative fibrosis and altered Ca2+handling, respectively. A growing body of evidence suggests an important role for the CamKII (Ca2+/calmodulin-dependent protein kinase II) in structural as well as in functional remodeling. In the sinus node, remodeling leads to degenerative fibrosis and as a consequence to sinus node arrest or to reentry (brady/tachycardia). In the atrium, remodeling sets the conditions for reentry and its triggering mechanisms, especially the conditions for triggered activity on the basis of delayed afterdepolarizations (DAD). Thus, SND and AF seem to be different phenotypes of related pathophysiological mechanisms. On the other hand, it remains controversial as to whether SND causes AF or vice versa.
authors.affiliation: Institut für Physiologie, Abteilung II, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 7, 79104, Freiburg, Deutschland. j.weirich@physiologie.uni-freiburg.de.
authors.forename: Jörg
authors.initials: J
authors.lastname: Weirich
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001281:Atrial Fibrillation / Q000150:complications / Q000503:physiopathology*; D064752:Atrial Remodeling; D020013:Calcium Signaling; D019317:Evidence-Based Medicine; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D012804:Sick Sinus Syndrome / Q000150:complications / Q000503:physiopathology*
keywords: Ca2+ handling; Fibrosis; Functional remodeling; Sick sinus syndrome; Triggered activity