title: Human cortical neural correlates of visual fatigue during binocular depth perception: An fNIRS study.
abstract: Functional near-infrared spectroscopy (fNIRS) was adopted to investigate the cortical neural correlates of visual fatigue during binocular depth perception for different disparities (from 0.1° to 1.5°). By using a slow event-related paradigm, the oxyhaemoglobin (HbO) responses to fused binocular stimuli presented by the random-dot stereogram (RDS) were recorded over the whole visual dorsal area. To extract from an HbO curve the characteristics that are correlated with subjective experiences of stereopsis and visual fatigue, we proposed a novel method to fit the time-course HbO curve with various response functions which could reflect various processes of binocular depth perception. Our results indicate that the parietal-occipital cortices are spatially correlated with binocular depth perception and that the process of depth perception includes two steps, associated with generating and sustaining stereovision. Visual fatigue is caused mainly by generating stereovision, while the amplitude of the haemodynamic response corresponding to sustaining stereovision is correlated with stereopsis. Combining statistical parameter analysis and the fitted time-course analysis, fNIRS could be a promising method to study visual fatigue and possibly other multi-process neural bases.
authors.affiliation: Centre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University (SCNU), Guangzhou, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Cai
authors.affiliation: Centre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University (SCNU), Guangzhou, China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Centre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University (SCNU), Guangzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Centre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University (SCNU), Guangzhou, China.|School of Information and Optoelectronic Science and Engineering, South China Normal University (SCNU), Guangzhou, China.
authors.forename: Shijing
authors.initials: S
authors.lastname: Wu
authors.affiliation: Centre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University (SCNU), Guangzhou, China.|South China Normal University (SCNU), Guangzhou, China.
authors.forename: Xinge
authors.initials: X
authors.lastname: Li
authors.affiliation: Centre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University (SCNU), Guangzhou, China.|Department of Electromagnetic Engineering, Royal Institute of Technology, Stockholm, Sweden.
authors.forename: Sailing
authors.initials: S
authors.lastname: He
mesh_terms: D000328:Adult; D001248:Asthenopia / Q000503:physiopathology*; D003867:Depth Perception; D005260:Female; D006801:Humans; D008297:Male; D009474:Neurons / Q000502:physiology*; D010108:Oxyhemoglobins / Q000378:metabolism; D010775:Photic Stimulation; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D015348:Vision, Binocular; D014793:Visual Cortex / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D010108:Oxyhemoglobins