title: [Comparison of agonists-induced contraction between main and the third-order branches of pulmonary arteries in rats].
abstract: This study was designed to observe the differences between main pulmonary arteries and the third-order branches of pulmonary arteries in the contractile response to phenylephrine (Phen), endothelin-1 (ET-1) and potassium chloride (KCl). The vascular tension changes of main and the third-order branches of pulmonary arteries induced by KCl, ET-1 and Phen were recorded by traditional vascular tone detection methods and microvascular ring technique, respectively. The results showed that Phen could cause a significant contraction in main pulmonary arteries, but did not induce apparent contraction in the third-order branches of pulmonary arteries. Compared with main pulmonary arteries, ET-1 contracted the third-order branches of pulmonary arteries with reduced maximal response value and PD2value. In comparison with the main pulmonary arteries, contraction caused by KCl was enhanced in the third-order branches of pulmonary arteries. The results suggest that the vascular reactivity of main and the third-order branches of pulmonary arteries is different and it is important to study the vascular function of small branches of pulmonary arteries. This study could provide an important experimental basis for the further study on vascular function of small branches of pulmonary arteries and the functional changes in pulmonary hypertension.
authors.affiliation: Department of Physiology and Pathophysiology; Lab of Cardiovascular Sciences, Fujian Medical University, Fuzhou 350108, China.|Quanzhou Medical College, Quanzhou 362000, China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Huang
authors.affiliation: Department of Physiology and Pathophysiology; Lab of Cardiovascular Sciences, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Yun-Ping
authors.initials: YP
authors.lastname: Mu
authors.affiliation: Department of Physiology and Pathophysiology; Lab of Cardiovascular Sciences, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Fu-Rong
authors.initials: FR
authors.lastname: Yan
authors.affiliation: Department of Physiology and Pathophysiology; Lab of Cardiovascular Sciences, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Jie-Ling
authors.initials: JL
authors.lastname: Zhu
authors.affiliation: Department of Physiology and Pathophysiology; Lab of Cardiovascular Sciences, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Xiao-Ru
authors.initials: XR
authors.lastname: Liu
authors.affiliation: Department of Physiology and Pathophysiology; Lab of Cardiovascular Sciences, Fujian Medical University, Fuzhou 350108, China. mjlin@mail.fjmu.edu.cn.
authors.forename: Mo-Jun
authors.initials: MJ
authors.lastname: Lin
mesh_terms: D000818:Animals; D019332:Endothelin-1 / Q000494:pharmacology*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects*; D051381:Rats; D014661:Vasoconstriction
chemical_list: D019332:Endothelin-1; D010656:Phenylephrine; D011189:Potassium Chloride