title: Prolongation of prothrombin time in the presence of rivaroxaban: is this the only cause?
abstract: Rivaroxaban is an oral direct Xa inhibitor that can lead to prolongation of prothrombin time and activated partial thromboplastin time. However, these basic coagulation tests are not specific for the anticoagulant effect of rivaroxaban and other confounding factors should be considered while interpreting the test results. We report a case of a patient on rivaroxaban, where underlying factor VII deficiency led to confusion in the interpretation of prothrombin time results and delayed her surgery.
authors.affiliation: Haematology Division, SA Pathology, Adelaide, South Australia, Australia.
authors.forename: Safoorah
authors.initials: S
authors.lastname: Sagheer
authors.affiliation: Haematology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: McRae
mesh_terms: D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications; D001777:Blood Coagulation / Q000187:drug effects; D065427:Factor Xa Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D000069552:Rivaroxaban / Q000009:adverse effects*; D020521:Stroke / Q000097:blood* / Q000188:drug therapy
chemical_list: D065427:Factor Xa Inhibitors; D000069552:Rivaroxaban
keywords: direct Xa inhibitor; factor VII deficiency; prothrombin time; rivaroxaban