title: Predictors of rehospitalization in a naturalistic cohort of patients with bipolar affective disorder.
abstract: There has only been limited research into the predictors of readmission in bipolar disorder. We carried out a 1-year follow-up of patients discharged from a single mental health unit following admission for treatment of an acute bipolar episode. Of 519 patients followed up for 1 year, 167 (32.2%) were readmitted. There was no association between readmission and any drug regimen. Prescription of antidepressants at discharge was not associated with increased risk of readmission [odds ratio (OR): 0.99, 95% confidence interval (CI): 0.98-1.01]. Among demographic factors, only smoking (OR: 1.75, 95% CI: 1.14-2.75) and age range of 42-53 years (OR: 1.99, 95% CI: 1.15-3.43) conferred an increased risk of readmission. Individually optimized drug treatment regimens are equally effective in practice. It is not clear why smoking is associated with readmission.
authors.affiliation: aDepartment of Pharmacy, Maudsley Hospital bSchool of Public Health, Imperial College cCentre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience dInstitute of Pharmaceutical Science, King's College, London, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: O'Hagan
authors.forename: Victoria
authors.initials: V
authors.lastname: Cornelius
authors.forename: Allan H
authors.initials: AH
authors.lastname: Young
authors.forename: David
authors.initials: D
authors.lastname: Taylor
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission / Q000706:statistics & numerical data*; D012307:Risk Factors
chemical_list: D000928:Antidepressive Agents