title: Bridgehead Nitrogen Thiazolo[3,2-a]pyrimidine: A Privileged Structural Framework in Drug Discovery.
abstract: BACKGROUND
  Thiazolopyrimidine derivatives containing bridgehead nitrogen atom are nowa- days attracting the attention of many medicinal chemists throughout the world to explore this framework for its potential. This biologically important scaffold is formed by the fusion of two aromatic rings, thiazole and pyrimidine, in such a way that one carbon atom at the ring junction is replaced by a nitrogen atom and is, therefore, being common for both the heterocyclic rings. One of the most common example of this type of fusion is thiazolo[3,2-a]pyrimidine which is being used perpetually with tremendous success in various fields of therapeutic applications.
  
  
  METHODS
  Despite the outstanding researches on thiazolo[3,2-a]pyrimidines in the literature, hardly there is a comprehensive review on the chemistry and medicinal values of present scaffold. This review is, therefore, to endow with highlights on assorted progress made over the recent past on the basis of the development of new synthetic strategies, structure of various synthesized molecules and their promising medicinal attributes.
  
  
  CONCLUSIONS
  In addition, we have undertaken various scientific reports in depth, to explain spectral characterization (UV, IR, Mass, NMR and X-ray crystallography) and stereochemistry, particularly of thiazolo[3,2-a]pyrimidines.
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025. India.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Keshari
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025. India.
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow-226025. India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Saha
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D055808:Drug Discovery; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D011743:Pyrimidines; D013844:Thiazoles; C000623116:thiazolo(3,2-a)pyrimidine
keywords: 2-a]pyrimidine; Biological activities; bridgehead nitrogen thiazolo[3; recent synthetic strategies; spectral characterization
  and X-ray crystallography; stereochemistry; thiazolopyrimidine.