title: Two cases of sudden death due to pulmonary tumor thrombotic microangiopathy caused by occult gastric carcinoma.
abstract: We present two cases of occult gastric carcinoma associated to a large pulmonary tumors thrombosis microangiopathy (PTTM). The first case is a 28 years-old man. He was dead due to a respiratory failure. Autopsy showed a whitish indurated mass invading the stomach wall. Histological findings showed a primary "signet ring" gastric adenocarcinoma with pulmonary carcinomatosis and multiple PTTM and a heart metastasis. The second case is a 24 years-old pregnant woman. The main symptoms were nausea and stomach discomfort and they were seen as pregnancy signs. She was dead because of respiratory failure, 10 hours after a vaginal delivery. Autopsy showed the absence of any cause of death related to the delivery and the presence of a whitish indurated mass in the stomach. Histological findings showed a primary "signet ring" gastric adenocarcinoma, with pulmonary carcinomatosis and multiple PTTM.
authors.affiliation: Department of Forensic Medicine, Charles Nicolle Hospital, Tunis, Tunisia.|Faculty of Medicine, University Tunis-Elmanar, Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Ben Khelil
authors.affiliation: Department of Forensic Medicine, Charles Nicolle Hospital, Tunis, Tunisia.|Faculty of Medicine, University Tunis-Elmanar, Tunis, Tunisia.
authors.forename: Y
authors.initials: Y
authors.lastname: Chkirbene
authors.affiliation: Departement of Pathology, La Rabta Hospital, Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Azzouz
authors.affiliation: Departement of Pathology, La Rabta Hospital, Tunis, Tunisia.|Faculty of Medicine, University Tunis-Elmanar, Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Haouet
authors.affiliation: Department of Forensic Medicine, Charles Nicolle Hospital, Tunis, Tunisia.|Faculty of Medicine, University Tunis-Elmanar, Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Hamdoun
mesh_terms: D000328:Adult; D001344:Autopsy; D018279:Carcinoma, Signet Ring Cell / Q000150:complications* / Q000556:secondary; D003645:Death, Sudden / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000556:secondary; D008297:Male; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology; D057049:Thrombotic Microangiopathies / Q000209:etiology* / Q000473:pathology; D055815:Young Adult
keywords: Autopsy; Forensic Pathology; Gastric cancer; Pulmonary tumor thrombotic microangiopathy; Sudden death