title: Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis.
abstract: Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds.
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, and.|Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, Durham, North Carolina.|Infectious Diseases Service, Department of Medicine, and.|Institute of Microbiology, Lausanne University Hospital, Switzerland ; and.
authors.forename: Frederic
authors.initials: F
authors.lastname: Lamoth
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, and.|Department of Infectious Diseases, Singapore General Hospital, Singapore.
authors.forename: Shimin J
authors.initials: SJ
authors.lastname: Chung
authors.affiliation: Infectious Diseases Service, Department of Medicine, and.
authors.forename: Lauro
authors.initials: L
authors.lastname: Damonti
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, and.|Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, Durham, North Carolina.
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Alexander
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001228:Aspergillosis / Q000453:epidemiology / Q000517:prevention & control; D001393:Azoles / Q000008:administration & dosage* / Q000494:pharmacology; D025141:Drug Resistance, Fungal; D005260:Female; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D000072742:Invasive Fungal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009091:Mucormycosis / Q000453:epidemiology / Q000517:prevention & control; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents; D001393:Azoles
keywords: Aspergillus ustus; Scopulariopsis.; antifungal prophylaxis; invasive aspergillosis; mucormycosis