title: Applied in situ product recovery in ABE fermentation.
abstract: The production of biobutanol is hindered by the product's toxicity to the bacteria, which limits the productivity of the process. In situ product recovery of butanol can improve the productivity by removing the source of inhibition. This paper reviews in situ product recovery techniques applied to the acetone butanol ethanol fermentation in a stirred tank reactor. Methods of in situ recovery include gas stripping, vacuum fermentation, pervaporation, liquid-liquid extraction, perstraction, and adsorption, all of which have been investigated for the acetone, butanol, and ethanol fermentation. All techniques have shown an improvement in substrate utilization, yield, productivity or both. Different fermentation modes favored different techniques. For batch processing gas stripping and pervaporation were most favorable, but in fed-batch fermentations gas stripping and adsorption were most promising. During continuous processing perstraction appeared to offer the best improvement. The use of hybrid techniques can increase the final product concentration beyond that of single-stage techniques. Therefore, the selection of an in situ product recovery technique would require comparable information on the energy demand and economics of the process. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:563-579, 2017.
authors.affiliation: School of Chemical Engineering and Advanced Material, Newcastle University, Newcastle-upon-Tyne, U.K.|Green Biologics Ltd, 45A Western Avenue, Milton Park, Abingdon, Oxfordshire, U.K.
authors.forename: Victoria
authors.identifier: http://orcid.org/0000-0002-0216-6114
authors.initials: V
authors.lastname: Outram
authors.affiliation: Green Biologics Ltd, 45A Western Avenue, Milton Park, Abingdon, Oxfordshire, U.K.
authors.forename: Carl-Axel
authors.initials: CA
authors.lastname: Lalander
authors.affiliation: School of Chemical Engineering and Advanced Material, Newcastle University, Newcastle-upon-Tyne, U.K.
authors.forename: Jonathan G M
authors.initials: JGM
authors.lastname: Lee
authors.affiliation: Green Biologics Ltd, 45A Western Avenue, Milton Park, Abingdon, Oxfordshire, U.K.
authors.forename: E Timothy
authors.initials: ET
authors.lastname: Davies
authors.affiliation: School of Chemical Engineering and Advanced Material, Newcastle University, Newcastle-upon-Tyne, U.K.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Harvey
mesh_terms: D000096:Acetone / Q000378:metabolism; D001709:Biotechnology / Q000379:methods; D000440:Butanols / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism; D005285:Fermentation / Q000502:physiology*
chemical_list: D000440:Butanols; D000096:Acetone; D000431:Ethanol
keywords: ABE Fermentation; In situ product recovery; n-Butanol