title: Decreased expression of Sema3A, an immune modulator, in blood sample of multiple sclerosis patients.
abstract: Semaphorin 3A (Sema3A) as an immune modulator could participate in the pathogenesis of autoimmune diseases. In the current study, we aimed to investigate Sema3A expression in peripheral blood mononuclear cells (PBMCs) and its serum level in relapsing-remitting multiple sclerosis (RRMS) patients. Fifteen newly determined and untreated RRMS patients were chosen and assessed in relapsing and remitting phases in compare with fifteen healthy individuals. In consistent with previous findings in other autoimmune diseases, our results revealed that serum level of Sema3A and its expression in PBMCs of RRMS patients were significantly lower than in normal subjects. We also evaluated this down regulation predictive value with ROC analysis. According to our data, we suggest that Sema3A could be involved in pathogenesis of MS and might be a potential diagnostic biomarker for the disease.
authors.affiliation: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Rezaeepoor
authors.affiliation: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Shapoori
authors.affiliation: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: mghakemi@med.mui.ac.ir.
authors.forename: Mazdak
authors.initials: M
authors.lastname: Ganjalikhani-Hakemi
authors.affiliation: Multiple Sclerosis and Neuroimmunology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Etemadifar
authors.affiliation: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Alsahebfosoul
authors.affiliation: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Eskandari
authors.affiliation: Department of Biostatistics and Epidemiology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Mansourian
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015536:Down-Regulation; D005260:Female; D015870:Gene Expression; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics*; D040121:Semaphorin-3A / Q000097:blood* / Q000235:genetics* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D040121:Semaphorin-3A
keywords: Autoimmune disease; Immune modulator; Multiple sclerosis; Semaphorin 3A