title: The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers.
abstract: The dispersion releaser (DR) is a dialysis-based setup for the analysis of the drug release from nanosized drug carriers. It is mounted into dissolution apparatus2 of the United States Pharmacopoeia. The present study evaluated the DR technique investigating the drug release of the model compound flurbiprofen from drug solution and from nanoformulations composed of the drug and the polymer materials poly (lactic acid), poly (lactic-co-glycolic acid) or Eudragit®RSPO. The drug loaded nanocarriers ranged in size between 185.9 and 273.6nm and were characterized by a monomodal size distribution (PDI<0.1). The membrane permeability constants of flurbiprofen were calculated and mathematical modeling was applied to obtain the normalized drug release profiles. For comparing the sensitivities of the DR and the dialysis bag technique, the differences in the membrane permeation rates were calculated. Finally, different formulation designs of flurbiprofen were sensitively discriminated using the DR technology. The mechanism of drug release from the nanosized carriers was analyzed by applying two mathematical models described previously, the reciprocal powered time model and the three parameter model.
authors.affiliation: Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Janas
authors.affiliation: Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany.
authors.forename: Marc-Phillip
authors.initials: MP
authors.lastname: Mast
authors.affiliation: Goethe University, Institute for Biophysics, D-60438 Frankfurt, Germany.
authors.forename: Li
authors.initials: L
authors.lastname: Kirsamer
authors.affiliation: Goethe University, Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, D-60590 Frankfurt, Germany.
authors.forename: Carlo
authors.initials: C
authors.lastname: Angioni
authors.affiliation: Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany.
authors.forename: Fiona
authors.initials: F
authors.lastname: Gao
authors.affiliation: Goethe University, Institute for Biophysics, D-60438 Frankfurt, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Mäntele
authors.affiliation: Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Dressman
authors.affiliation: Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany; Fraunhofer-Institute for Molecular Biology and Applied Ecology, Department of Pharmaceutical Technology and Nanosciences, D-60438 Frankfurt, Germany. Electronic address: matthias.wacker@ime.fraunhofer.de.
authors.forename: Matthias G
authors.initials: MG
authors.lastname: Wacker
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005480:Flurbiprofen / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011109:Polymethacrylic Acids / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004337:Drug Carriers; C496966:Eudragit RSPO; D011109:Polymethacrylic Acids; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005480:Flurbiprofen
keywords: Colloidal drug carriers; Dialysis; Drug release; Flurbiprofen; Mathematical modeling; USP apparatus 2