title: A Novel Protein Characterization Based on Pseudo Amino Acids Composition and Star-Like Graph Topological Indices.
abstract: OBJECTIVE
  The rapidly growing number of protein data available creates necessity of computational methods with low complexity to infer accurate protein structure, function, and evolution.
  
  
  METHODS
  A new description of proteins based on five topological indices of star-like graph representation and the occurrence frequency of 20 amino acids was proposed to compare the similarities of proteins.
  
  
  RESULTS
  A phylogenetic tree of eight ND6 proteins was constructed to demonstrate the effectiveness and rationality of our approach. Analogously, we applied this method to RNA polymerase proteins of some subtypes of influenza virus to infer their phylogenetic relationship. The results showed that the phylogenetic relationship among RNA polymerase of influenza virus is closely related to distributions of species virus host and geographical distribution.
  
  
  CONCLUSIONS
  This novel approach is based on a mapping which can be recaptured mathematically without loss of information.
authors.affiliation: School of Science, Zhejiang Sci-Tech University, Hangzhou 310018. China.
authors.forename: Ping-An
authors.initials: PA
authors.lastname: He
authors.affiliation: School of Science, Zhejiang Sci-Tech University, Hangzhou 310018. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Tao
authors.affiliation: School of Science, Zhejiang Sci-Tech University, Hangzhou 310018. China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Ma
authors.affiliation: College of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dai
authors.affiliation: College of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018. China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Yao
mesh_terms: D000465:Algorithms; D000596:Amino Acids / Q000737:chemistry / Q000235:genetics; D000818:Animals; D003196:Computer Graphics; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000235:genetics; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry / Q000201:enzymology / Q000235:genetics; D007251:Influenza, Human / Q000821:virology; D009245:NADH Dehydrogenase / Q000737:chemistry / Q000235:genetics; D009976:Orthomyxoviridae Infections / Q000821:virology; D010802:Phylogeny; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*
chemical_list: D000596:Amino Acids; D011506:Proteins; C507225:MT-ND6 protein, human; D009245:NADH Dehydrogenase; D012321:DNA-Directed RNA Polymerases
keywords: RNA polymerase; alignment-free; phylogenetic tree; pseudo amino acids composition; star-like graph; topological
  indices