title: In search of the mechanism that shapes the neutrophil's nucleus.
abstract: The organization of the genome within the confines of the nuclear compartment is considered a key contributor to transcription and DNA replication, repair, and recombination. A typical higher eukaryotic cell has a spherical nucleus that is ∼10 µm in diameter. This is not the case for a neutrophil, a short-lived innate immune cell with an unusual multilobular nuclear structure that may serve purposes outside nuclear functions. In this issue ofGenes & Development, Zhu and colleagues (pp. 141-153) investigate the neutrophil's genome organization and the mechanisms that contribute to its unique nuclear shape.
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
authors.forename: Katia
authors.initials: K
authors.lastname: Georgopoulos
mesh_terms: D002467:Cell Nucleus; D004261:DNA Replication; D016678:Genome; D006801:Humans; D009504:Neutrophils / Q000166:cytology*
keywords: Lamin B receptor; genome topology; neutrophils; nucleoli; rDNA