title: On the Uniqueness of the Standard Genetic Code.
abstract: In this work, we determine the biological and mathematical properties that are sufficient and necessary to uniquely determine both the primeval RNY (purine-any base-pyrimidine) code and the standard genetic code (SGC). These properties are: the evolution of the SGC from the RNY code; the degeneracy of both codes, and the non-degeneracy of the assignments of aminoacyl-tRNA synthetases (aaRSs) to amino acids; the wobbling property; the consideration that glycine was the first amino acid; the topological and symmetrical properties of both codes.
authors.affiliation: Theoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico. gazaso92@gmail.com.
authors.forename: Gabriel S
authors.initials: GS
authors.lastname: Zamudio
authors.affiliation: Theoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico. marcojose@biomedicas.unam.mx.
authors.forename: Marco V
authors.initials: MV
authors.lastname: José
keywords: RNY code; Standard genetic code; aminoacyl-tRNA synthetases; degeneracy; evolution of the genetic code; frozen code; symmetry