title: Targeting miRNAs by polyphenols: Novel therapeutic strategy for cancer.
abstract: In the recent years, polyphenols have gained significant attention in scientific community owing to their potential anticancer effects against a wide range of human malignancies. Epidemiological, clinical and preclinical studies have supported that daily intake of polyphenol-rich dietary fruits have a strong co-relationship in the prevention of different types of cancer. In addition to direct antioxidant mechanisms, they also regulate several therapeutically important oncogenic signaling and transcription factors. However, after the discovery of microRNA (miRNA), numerous studies have identified that polyphenols, including epigallocatechin-3-gallate, genistein, resveratrol and curcumin exert their anticancer effects by regulating different miRNAs which are implicated in all the stages of cancer. MiRNAs are short, non-coding endogenous RNA, which silence the gene functions by targeting messenger RNA (mRNA) through degradation or translation repression. However, cancer associated miRNAs has emerged only in recent years to support its applications in cancer therapy. Preclinical experiments have suggested that deregulation of single miRNA is sufficient for neoplastic transformation of cells. Indeed, the widespread deregulation of several miRNA profiles of tumor and healthy tissue samples revealed the involvement of many types of miRNA in the development of numerous cancers. Hence, targeting the miRNAs using polyphenols will be a novel and promising strategy in anticancer chemotherapy. Herein, we have critically reviewed the potential applications of polyphenols on various human miRNAs, especially which are involved in oncogenic and tumor suppressor pathways.
authors.affiliation: Department of Biotechnology, Alagappa University (Science Campus), Karaikudi 630 003, Tamil Nadu, India. Electronic address: devikasi@yahoo.com.
authors.forename: Kasi
authors.initials: K
authors.lastname: Pandima Devi
authors.affiliation: Department of Biotechnology, Alagappa University (Science Campus), Karaikudi 630 003, Tamil Nadu, India.
authors.forename: Tamilselvam
authors.initials: T
authors.lastname: Rajavel
authors.affiliation: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, 27100, Pavia, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL 33169, USA.
authors.forename: Anupam
authors.initials: A
authors.lastname: Bishayee
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran. Electronic address: Nabavi208@gmail.com.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives / Q000627:therapeutic use; D003474:Curcumin / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D019833:Genistein / Q000627:therapeutic use; D006801:Humans; D035683:MicroRNAs / Q000187:drug effects / Q000235:genetics*; D009369:Neoplasms / Q000178:diet therapy* / Q000235:genetics / Q000473:pathology; D059808:Polyphenols / Q000627:therapeutic use*; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000627:therapeutic use
chemical_list: D035683:MicroRNAs; D059808:Polyphenols; D013267:Stilbenes; D002392:Catechin; C045651:epigallocatechin gallate; D019833:Genistein; D003474:Curcumin; D000077185:Resveratrol
keywords: Cancer; MiRNA; OncomiR; Polyphenols; Tumor suppressor miRNA