title: Current evidence for AMPK activation involvement on resveratrol-induced neuroprotection in cerebral ischemia.
abstract: OBJECTIVE
  Cerebral ischemia is a neurological condition in which energetics and oxidative stress are dysregulated. Resveratrol is a stilbene with potent pharmacological effects associated with its antioxidant properties. In the brain, resveratrol produces protective responses against ischemia, decreases infarct volume and improves neurological function. Adenosine monophosphate-activated protein kinase (AMPK) is a cellular sensor that acts as a switch to initiate adaptive changes in response to fluctuations in energy metabolism.
  
  
  RESULTS
  In ischemia, AMPK is activated, nevertheless conflicting results about its contribution to protection have become apparent, and this matter continues without resolution. Interestingly, AMPK activation by resveratrol has been implicated in regulating cell survival in different experimental models. Although resveratrol's ability to regulate AMPK directly or after signaling is only beginning to be understood, targeting this enzyme by resveratrol in brain suggest that it could contribute to the amelioration of some pathologic features induced after an energetic deficit.
  
  
  CONCLUSIONS
  The present review discusses the potential role of resveratrol in regulating AMPK activity on brain before, during, or after ischemia and offer suggestions for feasible future studies.
authors.affiliation: a Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía 'Manuel Velasco Suárez' , Ciudad de México, 14269, México.
authors.forename: Narayana
authors.initials: N
authors.lastname: Pineda-Ramírez
authors.affiliation: a Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía 'Manuel Velasco Suárez' , Ciudad de México, 14269, México.
authors.forename: Germán Fernando
authors.initials: GF
authors.lastname: Gutiérrez Aguilar
authors.affiliation: b Laboratorio de Biología Molecular y Genómica , Universidad Autónoma de Guerrero , Chilpancingo , Guerrero, 39087, México.
authors.forename: Mónica
authors.initials: M
authors.lastname: Espinoza-Rojo
authors.affiliation: a Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía 'Manuel Velasco Suárez' , Ciudad de México, 14269, México.
authors.forename: Penélope
authors.initials: P
authors.lastname: Aguilera
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000201:enzymology* / Q000503:physiopathology; D002470:Cell Survival / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D051379:Mice; D000066829:Neuroprotection / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D011494:Protein Kinases / Q000378:metabolism* / Q000502:physiology; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D013267:Stilbenes; D011494:Protein Kinases; D000091162:AMP-Activated Protein Kinase Kinases; D000077185:Resveratrol
keywords: AMP-activated protein kinase; Antioxidants; Cerebral ischemia; Energy metabolism; Resveratrol