title: Endothelial cell activation in central nervous system inflammation.
abstract: Leukocyte migration across the endothelial barrier plays an essential role in CNS inflammation. The migration process requires complex endothelial adhesion molecules concentrated at the junctions of endothelial cells. Recent findings suggest that cerebral endothelial cells play an active role in the pathogenesis of CNS inflammatory diseases. This review describes our current understanding of the effects of various inflammatory mediators of leukocyte migration on cerebral endothelial cells, the mechanisms underlying the leukocyte-endothelial cell interactions, and the crosstalk between endothelial cells and glial cells or platelets. These emerging mechanisms may provide new therapeutic strategies for a variety of CNS inflammatory diseases.
authors.affiliation: Department of Immunology, Bengbu Medical College, Bengbu, China.
authors.forename: Fengjiao
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; and.
authors.forename: Lixin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, China hzhou@njmu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology / Q000473:pathology; D001812:Blood-Brain Barrier / Q000276:immunology / Q000473:pathology; D001921:Brain / Q000276:immunology* / Q000473:pathology; D002450:Cell Communication; D002465:Cell Movement; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D042783:Endothelial Cells / Q000276:immunology* / Q000473:pathology; D004730:Endothelium, Vascular / Q000276:immunology* / Q000473:pathology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016023:Integrins / Q000235:genetics / Q000276:immunology; D007962:Leukocytes / Q000276:immunology* / Q000473:pathology; D009457:Neuroglia / Q000276:immunology / Q000473:pathology; D019087:Selectins / Q000235:genetics / Q000276:immunology
chemical_list: D016207:Cytokines; D016023:Integrins; D019087:Selectins
keywords: adhesion molecules; central nervous system inflammation; endothelial cell; leukocyte migration