title: [Direct oral anticoagulants and acute stroke : Insights into translational research studies].
abstract: In recent years a considerable number of translational research studies on intracerebral hemorrhage and ischemic stroke have been published, which are characterized by a particular proximity to practical clinical questions. Animal research has provided insights into the pathophysiological processes and therapy effects, which have so far only been insufficiently investigated in clinical studies. This includes the effectiveness of a rapid reversal of anticoagulation in cases of anticoagulation-associated intracerebral hemorrhage and the safety of thrombolytic treatment in ischemic stroke occurring during treatment with anticoagulants. With the approval of the direct oral anticoagulants these problems have become of particular contemporary relevance. Of course, results from experimental translational studies on stroke cannot be directly translated into clinical routine. Nevertheless, these investigations help to understand the underlying processes and mechanisms and provide proof of concept data for new treatment strategies. This review summarizes the most relevant results in this field of research with a particular focus on practical clinical questions.
authors.affiliation: Klinik für Neurologie, Goethe-Universität, Schleusenweg 2-16, 60528, Frankfurt am Main, Deutschland. foerch@em.uni-frankfurt.de.
authors.forename: C
authors.initials: C
authors.lastname: Foerch
authors.affiliation: Klinik für Neurologie, Goethe-Universität, Schleusenweg 2-16, 60528, Frankfurt am Main, Deutschland.
authors.forename: J H
authors.initials: JH
authors.lastname: Schäfer
authors.affiliation: Klinik für Neurologie, Goethe-Universität, Schleusenweg 2-16, 60528, Frankfurt am Main, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Pfeilschifter
authors.affiliation: Klinik für Neurologie, Goethe-Universität, Schleusenweg 2-16, 60528, Frankfurt am Main, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Bohmann
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects*; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000503:physiopathology* / Q000517:prevention & control; D019317:Evidence-Based Medicine; D006801:Humans; D008955:Models, Cardiovascular; D020521:Stroke / Q000503:physiopathology* / Q000517:prevention & control*; D057170:Translational Research, Biomedical / Q000639:trends*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants
keywords: Animal model; Experimental research; Intracerebral hemorrhage; Ischemic stroke; Thrombolysis