title: Solitary PSMA-Positive Pulmonary Metastasis in Biochemical Relapse of Prostate Cancer.
abstract: A 63-year-old man with a history of prostate cancer, treated with resection, radiation, and androgen-depriving therapy over 4 years, was referred to our department with suspicion of recurrence based on increased blood PSA levels (1.60 ng/mL). Ga PSMA PET/CT identified a solitary, PSMA-positive pulmonary nodule in the right lung. After resection, histologic analysis confirmed prostatic origin, and the blood PSA level decreased to 0.13 ng/mL. Solitary pulmonary metastasis from prostate cancer is rare. The benefits of local treatment of a single metastasis even in advanced disease are disputed among oncologists. Here, biochemical response to resection was excellent.
authors.affiliation: From the *Department of Diagnostic and Interventional Radiology, †Center for Integrated Oncology, and ‡Department of Nuclear Medicine, University Hospital of Cologne, Cologne; and §Urology Center Refrath, Bergisch Gladbach, Germany.
authors.forename: Nils
authors.initials: N
authors.lastname: Große Hokamp
authors.forename: Carsten
authors.initials: C
authors.lastname: Kobe
authors.forename: Eric
authors.initials: E
authors.lastname: Linzenich
authors.forename: David
authors.initials: D
authors.lastname: Maintz
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
mesh_terms: D004492:Edetic Acid / Q000031:analogs & derivatives; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D019275:Radiopharmaceuticals
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid