title: Detrimental effect of deltamethrin on the central nervous system (synganglion) of Rhipicephalus sanguineus ticks.
abstract: Ticks are ectoparasites of medical and veterinary importance, which transmit many infectious agents, causing significant damage to the hosts. The "dog tick" Rhipicephalus sanguineus is responsible for transmitting several pathogens to dogs, motivating researchers to investigate efficient and sustainable control methods. Currently, chemical acaricides currently in use target the central nervous system (synganglion), which is responsible for controlling all the systemic functions of the ticks. Here, the neurotoxic potential of deltamethrin on the synganglion of unfed R. sanguineus female ticks was investigated. The results showed that the synganglion of the females belonging to the control group presented intact morphological characteristics; however, the ones from the treatment group (exposed to 1.5, 3.12 and 6.25 ppm of deltamethrin) displayed alterations, which were increasingly intense as the concentration increased. Observed alterations were mainly in the cortex region and in the neuropile, indicating that the deltamethrin is neurotoxic.
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: Melissa Carolina
authors.initials: MC
authors.lastname: Pereira
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: Ana Elisa
authors.initials: AE
authors.lastname: Gasparotto
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: Juliana Paneczko
authors.initials: JP
authors.lastname: Jurgilas
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: Letícia Aurora Coelho
authors.initials: LA
authors.lastname: da Silva
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: Mayara Cristina
authors.initials: MC
authors.lastname: Pereira
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: Samantha Santos
authors.initials: SS
authors.lastname: Silveira
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: Thays Neigri
authors.initials: TN
authors.lastname: Silva
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Arnosti
authors.affiliation: Sao Paulo State University (UNESP) "Júlio de Mesquita Filho", Avenida 24 A, 1515, Rio Claro, SP, 13506-900, Brazil. micm@rc.unesp.br.
authors.forename: Maria Izabel
authors.initials: MI
authors.lastname: Camargo-Mathias
mesh_terms: D056810:Acaricides / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D009570:Nitriles / Q000494:pharmacology*; D011722:Pyrethrins / Q000494:pharmacology*; D048508:Rhipicephalus sanguineus / Q000187:drug effects* / Q000502:physiology
chemical_list: D056810:Acaricides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin
keywords: Acaricide; Morphology; Neurotoxicity; Ticks