title: A comparison of pattern of psychiatric symptoms in inpatients with bipolar disorder type one with & without methamphetamine use.
abstract: Background:Iran is facing an outbreak of methamphetamine-induced disorders and frequent use of these substances in patients with bipolar disorder. Using or intoxication of methamphetamine in patients with bipolar I disorder may alter the patient's clinical profile; however there is limited studies about impact of methamphetamine on clinical manifestation of bipolar disorders. This study aimed to compare psychiatric symptoms in patients with bipolar I disorder with and without concomitant use of methamphetamine.Methods:In a cross-sectional study, psychiatric symptoms of bipolar I disorder in patients with (Meth+) and without (Meth-) methamphetamine use was evaluated. A number of 57 participants with Meth + and 50 subjects with Meth- were recruited. The clinical picture of bipolar disorder was investigated by Young Mania Rating Scale (YMRS), 17-item Hamilton Depressive Rating Scale (HDRS-17) and the Scale for Assessment of Positive Symptoms (SAPS). Statistical comparisons were performed using the T-test for independent samples and Mann- Whitney test.Results:There was no statistically significant difference between two groups regarding age, duration of illness and hospitalizations. However, male participants were significantly higher in Meth+ group than in Meth- one (p<0.001). The mean (± SD) scores in the two groups of Meth+ and Meth- for YMRS, HDRS, and SAPS were 31.3 (±1.3) and 34.0 (±1.2), 13.7 (±0.7) and 13.5±(0.5), and 50.0 (±1.9) and 48.0 (±2.1), respectively, which were not statistically significant (p<0.05).Conclusion:There was no significant difference in the overall clinical manifestation of bipolar I disorder in patients with and without methamphetamine use. However, in some symptomatology domains, there were some differences between the two groups.
authors.affiliation: Resident of Psychiatry, Department of Psychiatry, Iran University of Medical Science, Tehran, Iran. elhamgouran@gmail.com.
authors.forename: Elham
authors.initials: E
authors.lastname: Gouran Ourimi
authors.affiliation: Mental Health Research Center, Bipolar Disorders Research Group, Iran University of Medical Sciences, Tehran, Iran. shabani.a@iums.ac.ir.
authors.forename: Amir
authors.initials: A
authors.lastname: Shabani
authors.affiliation: Mental Health Research Center, Bipolar Disorders Research Group, Iran University of Medical Sciences, Tehran, Iran. kavehalavi@yahoo.com.
authors.forename: Kaveh
authors.initials: K
authors.lastname: Alavi
authors.affiliation: Resident of Psychiatry, Department of Psychiatry, Iran University of Medical Science, Tehran, Iran. najarzadegan2010@gmail.com.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Najarzadegan
authors.affiliation: Resident of Psychiatry, Department of Psychiatry, Iran University of Medical Science, Tehran, Iran. f.sm6876@gmail.com.
authors.forename: Fatemehsadat
authors.initials: F
authors.lastname: Mirfazeli
keywords: Bipolar one disorder; Manic episode; Methamphetamine; Psychosis