title: Physical function and muscle strength in sporadic inclusion body myositis.
abstract: BACKGROUND
  In this study, self-reported physical function, functional capacity, and isolated muscle function were investigated in sporadic inclusion body myositis (sIBM) patients.
  
  
  METHODS
  The 36-item Short Form (SF-36) Health Survey and 2-min walk test (2MWT), timed up & go test (TUG), and 30-s chair stand performance were evaluated. In addition, patients were tested for knee extensor muscle strength (isokinetic dynamometer) and leg extension power (Nottingham power rig).
  
  
  RESULTS
  TUG performance was the strongest predictor of self-reported physical function (r2= 0.56, P < 0.05). Knee extension strength and between-limb strength asymmetry were the strongest multi-regression indicators of TUG performance (r2= 0.51, P < 0.05). Strength asymmetry showed the strongest single-factor (negative) association with 2MWT performance (r2= 0.49, P < 0.05).
  
  
  CONCLUSIONS
  TUG assessment appears to sensitively predict self-perceived physical function in sIBM patients. Notably, between-limb asymmetry in lower limb muscle strength had a substantial negative impact on motor tasks involving gait function. Muscle Nerve 56: E50-E58, 2017.
authors.affiliation: Department of Rheumatology, Odense University Hospital, Odense, Denmark.|Department of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark.
authors.forename: Anders N
authors.identifier: http://orcid.org/0000-0001-7330-8637
authors.initials: AN
authors.lastname: Jørgensen
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark.
authors.forename: Per
authors.initials: P
authors.lastname: Aagaard
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark.
authors.forename: Jakob L
authors.initials: JL
authors.lastname: Nielsen
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark.
authors.forename: Mette
authors.initials: M
authors.lastname: Christiansen
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark.
authors.forename: Lars G
authors.initials: LG
authors.lastname: Hvid
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Frandsen
authors.affiliation: Department of Rheumatology, Odense University Hospital, Odense, Denmark.
authors.forename: Louise P
authors.initials: LP
authors.lastname: Diederichsen
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018979:Myositis, Inclusion Body / Q000175:diagnosis* / Q000503:physiopathology* / Q000523:psychology; D011788:Quality of Life / Q000523:psychology; D020127:Recovery of Function / Q000502:physiology*
keywords: functional capacity; inclusion body myositis; inflammatory myopathy; muscle strength; physical function