title: The prognostic value of lymph node ratio and log odds of positive lymph nodes in patients with lung adenocarcinoma.
abstract: To investigate whether lymph node ratio and log odds ratio can be used for predicting the prognosis of patients with lung adenocarcinoma.
  
  
  
  A total of 1097 patients with lung adenocarcinoma who underwent complete surgical resection and systematic lymph node dissection between 2008 and 2013 were studied retrospectively. Lymph node ratio was calculated as: positive lymph nodes total lymph nodes . Log odds ratio was calculated as: logpositivelymph nodes+0.5total lymph nodes-positive lymph nodes+0.5. Patients were grouped respectively into 4 groups by the use of recursive partitioning according to their lymph node ratio and log odds ratio. Linear trend χ2test was used for measuring monotonicity and discriminatory power.
  
  
  
  The 3-year survival rate was 91.0% (89.9%-92.1%) for group 0, 75.2% (71.4%-79.0%) for group 1, 56.5% (51.5%-61.5%) for group 2, and 41.4% (36.4%-46.4%) for group 3 of lymph node ratio, respectively. In addition, the 3-year survival rate was 89.9% (88.7%-91.1%) for group 1, 78.4% (74.4%-82.4%) for group 2, 56.0% (50.9%-61.1%) for group 3, and 41.0% (36.1%-45.9%) for group 4 of log odds ratio, respectively. Univariable and multivariable Cox models identified that both lymph node ratio and log odds ratio were significant prognostic factors for patients' survival. Log-rank test of trend χ2statistics of both lymph node ratio (P < .001) and log odds ratio (P < .001) showed significant differences.
  
  
  
  Both lymph node ratio and log odds ratio can be used as prognostic factors for clinicians to predict patients' prognosis.
authors.affiliation: Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Department of Interventional Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Difan
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Jia
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Dai
authors.affiliation: Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: Sun_yihua76@hotmail.com.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: hqchen1@yahoo.com.
authors.forename: Haiquan
authors.initials: H
authors.lastname: Chen
mesh_terms: D000077192:Adenocarcinoma of Lung / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000601:surgery; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
keywords: log odds ratio; lung adenocarcinoma; lymph node ratio; prognostic value