title: Refractive, Topographic, and Aberrometric Results at 2-Year Follow-Up for Accelerated Corneal Cross-Link for Progressive Keratoconus.
abstract: Purpose. To report the visual, refractive, and corneal topography and wavefront aberration results of accelerated corneal cross-linking (CXL) during a 24-month follow-up.Methods. Forty-seven eyes underwent riboflavin-ultraviolet A-induced accelerated CXL treatment (30 mW/cm2with a total dose of 7.2 joules/cm2). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical and cylindrical values, keratometry (K) measurements (Ksteep,Kflat,Kavg, andKapex), central corneal thickness, and anterior corneal aberrometric analyses including total wavefront error (WFE), total high order aberration (HOA), astigmatism, trefoil, coma, quadrafoil, secondary astigmatism, and spherical aberration were evaluated.Results. The mean UDVA and CDVA were significantly improved at 1 (p= 0.003 andp= 0.004, resp.) and 2 years after treatment (p= 0.001 andp= 0.001, resp.). The meanKsteep,Kflat,Kaverage, andKapexvalues were significantly lower than baseline at 12 months (p= 0.008,p= 0.024,p= 0.001, andp= 0.014, resp.) and 24 months (p= 0.014,p= 0.017,p= 0.001, andp= 0.012, resp.). Corneal thickness showed a significant decrease at 1 month. Total HOA and coma decreased significantly at the 12-month (p= 0.001 andp= 0.009, resp.) and 24-month visits (p= 0.001 andp= 0.007, resp.).Conclusion. Accelerated CXL (30 mW/cm2) was found to be effective in improving UDVA, CDVA, corneal topography readings, total HOA, and coma aberrations during the 24-month follow-up.
authors.affiliation: Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Ercüment
authors.initials: E
authors.lastname: Bozkurt
authors.affiliation: Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Engin Bilge
authors.identifier: 0000-0003-1578-148X
authors.initials: EB
authors.lastname: Ozgurhan
authors.affiliation: Umraniye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Betul Ilkay Sezgin
authors.initials: BI
authors.lastname: Akcay
authors.affiliation: Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Kurt
authors.affiliation: Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Zehra Karaagaç
authors.initials: ZK
authors.lastname: Günaydin
authors.affiliation: Istanbul Medeniyet University Medical School, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirok