title: Age-Specific Differences in the Duration of Prehospital Cardiopulmonary Resuscitation Administered by Emergency Medical Service Providers Necessary to Achieve Favorable Neurological Outcome After Out-of-Hospital Cardiac Arrest.
abstract: The appropriate duration of prehospital cardiopulmonary resuscitation (CPR)administered by emergency medical service (EMS) providers for patients with out-of-hospital cardiac arrest (OHCA) necessary to achieve 1-month survival with favorable neurological outcome (Cerebral Performance Category 1 or 2, CPC 1-2) is unclear and could differ by age.
  
  
  
  We analyzed the records of 35,709 adult OHCA patients with return of spontaneous circulation (ROSC) before hospital arrival in a prospectively recorded Japanese registry between 2011 and 2014. The CPR duration was defined as the time from CPR initiation by EMS providers to prehospital ROSC. The rate of 1-month CPC 1-2 was 21.4% (7,650/35,709). The CPR duration was independently and inversely associated with 1-month CPC 1-2 (adjusted odds ratio, 0.93 per 1-min increment; 95% confidence interval, 0.93-0.94). The CPR duration increased with age (P<0.001). However, the CPR duration beyond which the proportion of OHCA patients with 1-month CPC 1-2 decreased to <1% declined with age: 28 min for patients aged 18-64 years, 25 min for 65-74 years, 23 min for 75-84 years, 20 min for 85-94 years, and 18 min for ≥95 years.
  
  
  
  In patients who achieved prehospital ROSC after OHCA, the duration of CPR administered by EMS providers necessary to achieve 1-month CPC 1-2 varied by age.
authors.affiliation: Department of Emergency and Critical Care Medicine, Kanazawa University Hospital.|Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa University.
authors.forename: Akira
authors.initials: A
authors.lastname: Funada
authors.affiliation: Department of Emergency and Critical Care Medicine, Kanazawa University Hospital.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Goto
authors.affiliation: Department of Emergency and Critical Care Medicine, Kanazawa University Hospital.|Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa University.
authors.forename: Hayato
authors.initials: H
authors.lastname: Tada
authors.affiliation: Department of Emergency and Critical Care Medicine, Kanazawa University Hospital.|Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa University.
authors.forename: Ryota
authors.initials: R
authors.lastname: Teramoto
authors.affiliation: Department of Emergency and Critical Care Medicine, Kanazawa University Hospital.|Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa University.
authors.forename: Masaya
authors.initials: M
authors.lastname: Shimojima
authors.affiliation: Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa University.
authors.forename: Kenshi
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa University.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016887:Cardiopulmonary Resuscitation / Q000379:methods* / Q000401:mortality; D004632:Emergency Medical Services / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D009422:Nervous System Diseases / Q000517:prevention & control*; D058687:Out-of-Hospital Cardiac Arrest / Q000150:complications / Q000401:mortality; D012042:Registries; D013534:Survival; D013997:Time Factors; D055815:Young Adult
keywords: Aging; Cardiopulmonary resuscitation; Epidemiology; Out-of-hospital cardiac arrest