title: Macrocycles, the edge of drug-likeness chemical space or Goldilocks zone?
authors.affiliation: The Wolfson Institute for Biomedical Research, University College London, London, UK.
authors.forename: David L
authors.initials: DL
authors.lastname: Selwood
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D047250:Calixarenes / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003505:Cyclodextrins / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery / Q000379:methods; D004917:Erythromycin / Q000737:chemistry / Q000494:pharmacology; D019791:Guanidine / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology; D045725:Tetrapyrroles / Q000737:chemistry / Q000494:pharmacology; D000077362:Verteporfin
chemical_list: D000900:Anti-Bacterial Agents; D003505:Cyclodextrins; D007211:Indoles; D047028:Macrocyclic Compounds; D018942:Macrolides; D017319:Photosensitizing Agents; D011166:Porphyrins; D045725:Tetrapyrroles; C553423:carolacton; D000077362:Verteporfin; D047250:Calixarenes; D004917:Erythromycin; D019791:Guanidine