title: Stem cell, biomaterials and growth factors therapy for hepatocellular carcinoma.
abstract: Hepatocellular carcinoma is an antecedent of liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. Transforming growth factor-Beta (TGF-b) plays an important role in creating a favorable microenvironment for tumor cell growth via two major mechanisms: an intrinsic activity as an autocrine growth factor and an extrinsic activity by inducing microenvironment changes. Recently stem cell therapy as also been a promising and potential treatment for liver cancer and in addition signaling pathways like GF/GFR systems, SDF-1α/CXC4 ligand receptor interaction and PI3K/Akt signaling, and cytokines has been identified to regulate cell fate decisions, and can be utilized to positively influence cell therapy outcomes. Thus stem cell-based therapy, together with signaling pathways can become a practical option in regenerative processes for replacing dead hepatocytes cells. Targeted drug delivery systems (TDDS) via biomaterials are presently been explored for cancer therapeutics especially liver cancer as it allows the enhancement of drug concentration in the liver and decrease the dosage and side effects. This review is intended to give a comprehensive summary of available liver cancer therapy using stem cells, growth factor and biomaterials.
authors.affiliation: Department of Internal Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran.
authors.forename: Soleiman
authors.initials: S
authors.lastname: Jaferian
authors.affiliation: Student Research committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Soleymaninejad
authors.affiliation: Department of Medical Biotechnology, School of Advance Science in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Negahdari
authors.affiliation: Department of Medical Biotechnology, School of Advance Science in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: a-eatemadi@razi.tums.ac.ir.
authors.forename: Ali
authors.initials: A
authors.lastname: Eatemadi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000628:therapy*; D033581:Stem Cell Transplantation; D017154:Stromal Cells / Q000473:pathology
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins
keywords: Growth factors; Hepatocytes; Liver cancer; Stem cells; Therapy