title: Dual Infection with Hepatitis B and Epstein-Barr Virus Presenting with Severe Jaundice, Coagulopathy, and Hepatitis B Virus Chronicity Outcome.
abstract: BACKGROUND Hepatitis B virus (HBV) has been reported as a coinfection with hepatitis C virus (HCV), hepatitis D virus (HDV), cytomegalovirus (CMV), and human immunodeficiency virus (HIV). CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. The patient was diagnosed with acute HBV with Epstein-Barr virus (EBV) coinfection leading to subsequent chronic hepatitis B. CONCLUSIONS To our knowledge, this patient case is the first reported case of HBV and EBV coinfection reported in the literature. HBV and EBV coinfection may cause severe acute hepatitis with HBV chronicity.
authors.affiliation: Department of Internal Medicine, University of Missouri Hospital , Columbia, MO, USA.
authors.forename: Sirish C
authors.initials: SC
authors.lastname: Rao
authors.affiliation: Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
authors.forename: Imran
authors.initials: I
authors.lastname: Ashraf
authors.affiliation: Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
authors.forename: Fazia
authors.initials: F
authors.lastname: Mir
authors.affiliation: Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
authors.forename: Sami
authors.initials: S
authors.lastname: Samiullah
authors.affiliation: Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
authors.forename: Jamal A
authors.initials: JA
authors.lastname: Ibdah
authors.affiliation: Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
authors.forename: Veysel
authors.initials: V
authors.lastname: Tahan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001778:Blood Coagulation Disorders / Q000821:virology*; D060085:Coinfection; D003937:Diagnosis, Differential; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D006515:Hepatitis B virus / Q000302:isolation & purification*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood; D007244:Infectious Mononucleosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D007565:Jaundice / Q000821:virology*; D012720:Severity of Illness Index; D000637:Transaminases / Q000097:blood
chemical_list: D015415:Biomarkers; D000637:Transaminases