title: Kikuchi-Fujimoto Disease with 18F-Fludeoxyglucose Uptake in Cervical Lymph Nodes on Dual-time-point Imaging Positron Emission Tomography/Computed Tomography Mimicking Malignant Disease.
abstract: Kikuchi-Fujimoto disease (KFD) is a benign but self-limiting disorder. However, KFD is often misdiagnosed as a malignant disease. Although 18F-fludeoxyglucose (FDG) uptake on dual-time-point imaging (DTPI) positron emission tomography (PET)/computed tomography (CT) is useful in distinguishing malignant from benign disease, the latter sometimes mimics malignancy on DTPI PET/CT, resulting in a misdiagnosis. Here, we describe the case of a 30-year-old woman who complained of cervical lymphadenopathy. PET showed increased FDG uptake in multiple lymph nodes, with a maximum standardized uptake value (SUVmax) of 19.0 in the early phase to 21.8 in the late phase. A biopsy was performed, and pathological examination revealed KFD. KFD with FDG uptake in lymph nodes on DTPI PET/CT is rare and difficult to be distinguished from a malignant disease.
authors.affiliation: Division of Oral and Maxillofacial Surgery, School of Medicine, Tokai University, Tokyo, Japan; Division of Oral and Maxillofacial Surgery, Oiso Hospital, Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Aoyama
authors.affiliation: Division of Oral and Maxillofacial Surgery, School of Medicine, Tokai University, Tokyo, Japan.
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Otsuru
authors.affiliation: Division of Oral and Maxillofacial Surgery, School of Medicine, Tokai University, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Uchibori
authors.affiliation: Division of Oral and Maxillofacial Surgery, School of Medicine, Tokai University, Tokyo, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Ota
keywords: Cervical lymphadenopathy; Kikuchi-Fujimoto disease; dual-time-point imaging; fludeoxyglucose-positron emission tomography/computed tomography