title: The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.
abstract: A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at different times and places, therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all the relevant Parkinson's disease genes; then, the association of LRRK2 with macroautophagy and the endolysosomal pathway will be analyzed based on the supporting literature.
authors.affiliation: School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, U.K. c.manzoni@reading.ac.uk.|Department of Molecular Neuroscience, University College London, Queen Square House, London WC1N 3BG, U.K.
authors.forename: Claudia
authors.initials: C
authors.lastname: Manzoni
mesh_terms: D001343:Autophagy; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Q000235:genetics / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction; D033921:Vesicular Transport Proteins / Q000235:genetics / Q000378:metabolism; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism
chemical_list: C497604:SNCA protein, human; C419573:VPS35 protein, human; D033921:Vesicular Transport Proteins; D051844:alpha-Synuclein; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
keywords: Parkinson's disease; autophagy; leucine-rich repeat kinase; neurodegeneration