title: The association between soluble intercellular adhesion molecule-1 levels in drained dialysate and peritoneal injury in peritoneal dialysis.
abstract: BACKGROUND
  Chronic inflammation of the peritoneum causes peritoneal injury in patients on peritoneal dialysis. Intercellular adhesion molecule-1 and its circulating form, soluble intercellular adhesion molecule-1, play pivotal roles in inflammation. However, their role in peritoneal injury is unclear.
  
  
  METHODS
  We measured changes in intercellular adhesion molecule-1 expression in the peritoneum of a peritoneal injury model in rats. The associations between soluble intercellular adhesion molecule-1 levels in drained dialysate and the solute transport rate (D/P-Cr and D/D0-glucose) determined by the peritoneal equilibration test, and matrix metalloproteinase-2 levels in drained dialysate were investigated in 94 peritoneal drained dialysate samples.
  
  
  RESULTS
  Intercellular adhesion molecule-1 expression was increased in the peritoneum of rats with peritoneal injury. Soluble intercellular adhesion molecule-1 levels in drained dialysate were significantly positively correlated with D/P-Cr (r = .51, p < .01) and inversely correlated with D/D0-glucose (r = -.44, p < .01). They were also significantly positively correlated with matrix metalloproteinase-2 levels in drained dialysate (r = .86, p < .01).
  
  
  CONCLUSIONS
  Intercellular adhesion molecule-1expression is increased in the peritoneum of a peritoneal injury model in the rat, and soluble intercellular adhesion molecule-1 levels in drained dialysate are associated with peritoneal injury in patients on peritoneal dialysis. These results suggest that soluble intercellular adhesion molecule-1 could be a novel biomarker of peritoneal injury in patients on peritoneal dialysis.
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Igarashi
authors.affiliation: b Division of Nephrology, Department of Integrated Medicine , Saitama Medical Center, Jichi Medical University , Omiya, Saitama City, Saitama , Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Morishita
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yoshizawa
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Reika
authors.initials: R
authors.lastname: Imai
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Imai
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirahara
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Akimoto
authors.affiliation: b Division of Nephrology, Department of Integrated Medicine , Saitama Medical Center, Jichi Medical University , Omiya, Saitama City, Saitama , Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Ookawara
authors.affiliation: c Department of Medical Physiology , Meiji Pharmaceutical University , Kiyose , Tokyo , Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ishibashi
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Muto
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nagata
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D015314:Dialysis Solutions / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000378:metabolism* / Q000473:pathology*; D011765:Pyruvaldehyde / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; D015314:Dialysis Solutions; C573420:ICAM1 protein, human; C000609942:ICAM1 protein, rat; D018799:Intercellular Adhesion Molecule-1; D011765:Pyruvaldehyde; D020778:Matrix Metalloproteinase 2
keywords: Drained dialysate; ICAM-1; peritoneal dialysis; peritoneal injury; sICAM-1