title: Preparation and characterization of quercetin/dietary fiber nanoformulations.
abstract: Quercetin is well known for its beneficial health effects on the human body. However, the slow dissolution rate leading to poor bioavailability constitutes a barrier to being further developed for nutritional products. In this work, quercetin was co-precipitated with dietary fibers into a fast-dissolving nanoformulation via antisolvent precipitation, followed by spray drying. With the help of cellulose fiber, resistant starch or resistant maltodextrin, a high dissolution rate and good storage stability was achieved for quercetin nanoformulations. In addition, nanoformulations exhibited higher level of antioxidant activities in contrast to raw quercetin. The developed quercetin/dietary fiber nanoformulations could be used as supplements or functional ingredients for food development.
authors.affiliation: Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, 627833, Singapore.
authors.forename: Chia Miang
authors.initials: CM
authors.lastname: Khor
authors.affiliation: Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, 627833, Singapore.
authors.forename: Wai Kiong
authors.initials: WK
authors.lastname: Ng
authors.affiliation: Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, 627833, Singapore.
authors.forename: Kok Ping
authors.initials: KP
authors.lastname: Chan
authors.affiliation: Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, 627833, Singapore. Electronic address: dong_yuancai@ices.a-star.edu.sg.
authors.forename: Yuancai
authors.initials: Y
authors.lastname: Dong
mesh_terms: D001682:Biological Availability; D004043:Dietary Fiber; D019587:Dietary Supplements; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry*
chemical_list: D004043:Dietary Fiber; D011794:Quercetin
keywords: Cellulose fiber; Nanoformulation; Quercetin; Resistant maltodextrin; Resistant starch