title: Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis.
abstract: Gastric cancer is currently the second leading cause of cancer-related death worldwide, especially in Japan, Korea and China, and the 5-year survival rate of gastric cancer is less than 30%. Thus, it is important to shed more lights on novel agents to prevent gastric cancer or to improve survival rate of the patients. Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Although epidemiological results are not consistent, accumulating evidence from gastric cancer cells, animal models, and clinical trials suggest that vitamin D deficiency may increase the risk and mortality of gastric cancer, but vitamin D supplement might be a safe and economical way to prevent or treat gastric cancer. Here, we reviewed the current studies on vitamin D and its receptor and focused on the pathogenic roles of their alterations in gastric tumorigenesis.
authors.affiliation: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.|Department of Gastroenterology and Hepatology, Chengdu Military General Hospital, Sichuan Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Shiming
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.|Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, California, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D006801:Humans; D051381:Rats; D017208:Rats, Wistar; D018167:Receptors, Calcitriol / Q000378:metabolism*; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000178:diet therapy* / Q000473:pathology; D015996:Survival Rate; D014807:Vitamin D / Q000494:pharmacology; D014808:Vitamin D Deficiency / Q000628:therapy*
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014807:Vitamin D
keywords: gastric cancer; tumorigenesis; vitamin D; vitamin D receptor