title: Core (Polystyrene)-Shell [Poly(glycerol monomethacrylate)] Particles.
abstract: A set of water-swollen core-shell particles was synthesized by emulsion polymerization of a 1,3-dioxolane functional monomer in water. After removal of the 1,3-dioxolane group, the particles' shells were shown to swell in aqueous media. Upon hydrolysis, the particles increased in size from around 70 to 100-130 nm. A bicinchoninic acid assay and ζ-potential measurements were used to investigate the adsorption of lysozyme, albumin, or fibrinogen. Each of the core-shell particles adsorbed significantly less protein than the noncoated core (polystyrene) particles. Differences were observed as both the amount of difunctional, cross-linking monomer and the amount of shell monomer in the feed were changed. The core-shell particles were shown to be resistant to protein adsorption, and the degree to which the three proteins adsorbed was dependent on the formulation of the shell.
authors.affiliation: Department of Chemistry, University of Sheffield , Sheffield, South Yorkshire S3 7HF, U.K.
authors.forename: Andrew
authors.initials: A
authors.lastname: Mckenzie
authors.affiliation: School of Chemistry and Biosciences, University of Bradford , Bradford, West Yorkshire BD7 1DP, U.K.
authors.forename: Richard
authors.initials: R
authors.lastname: Hoskins
authors.affiliation: School of Chemistry and Biosciences, University of Bradford , Bradford, West Yorkshire BD7 1DP, U.K.
authors.forename: Thomas
authors.identifier: http://orcid.org/0000-0002-8616-8458
authors.initials: T
authors.lastname: Swift
authors.affiliation: Department of Engineering, University of Bradford , Bradford, West Yorkshire BD7 1DP, U.K.
authors.forename: Colin
authors.initials: C
authors.lastname: Grant
authors.affiliation: School of Chemistry and Biosciences, University of Bradford , Bradford, West Yorkshire BD7 1DP, U.K.
authors.forename: Stephen
authors.identifier: http://orcid.org/0000-0002-1048-1974
authors.initials: S
authors.lastname: Rimmer
keywords: core−shell; emulsion polymerization; hydrogel; particles; protein adsorption