title: Impact of Early Nutrition on Body Composition in Children Aged 9.5 Years Born with Extremely Low Birth Weight.
abstract: To evaluate body composition, metabolism and growth as well as their interaction with early nutrition in former extremely low birth weight infants (ELBW), we assessed qualitative and quantitative nutritional intake during initial hospitalization and infantile growth parameters in 61 former ELBW infants with a birth weight <1000 g. In two follow-up exams, physical and biochemical development were measured at 5.7 and at 9.5 years. At the second follow-up, in addition to biochemical reassessment, body composition was analyzed by dual-energy x-ray absorptiometry (DEXA). Protein intake between birth and discharge was associated with weight gain in the first six months of life (r= 0.51;p< 0.01). Weight catch-up preceded height catch-up. Protein intake in early infancy correlated highly significantly with abdominal fat mass (r= 0.49;p< 0.05), but not with lean body mass at 9.5 years (r= 0.30; not significant (n.s.). In contrast to nutrient intake, birth weight was associated with lean body mass (r= 0.433;p< 0.001). Early protein and carbohydrate intake were associated with high-density lipoprotein (HDL)-cholesterol, and early catch-up growth correlated with fasting insulin at follow-up. Stepwise linear regression demonstrated that protein intake predicted fat mass (p< 0.05), whereas only gender and birth weight standard deviation score (SDS) contributed significantly to lean body mass variation (p< 0.05). Our results suggest an important impact of early nutrient intake on body composition and metabolism in later childhood in ELBW children.
authors.affiliation: Paediatric Endocrinology Division, Children's Hospital, University of Bonn, 53113 Bonn, Germany. sonja.stutte@ukb.uni-bonn.de.
authors.forename: Sonja
authors.initials: S
authors.lastname: Stutte
authors.affiliation: Paediatric Endocrinology Division, Children's Hospital, University of Bonn, 53113 Bonn, Germany. bettina.gohlke@ukb.uni-bonn.de.
authors.forename: Bettina
authors.initials: B
authors.lastname: Gohlke
authors.affiliation: Department for Orthopedic surgery, Franziskus Hospital, 53545 Linz, Germany. info@krankenhaus-linz.de.
authors.forename: Annika
authors.initials: A
authors.lastname: Peiler
authors.affiliation: Paediatric Endocrinology Division, Children's Hospital, University of Bonn, 53113 Bonn, Germany. felix.schreiner@ukb.uni-bonn.de.
authors.forename: Felix
authors.initials: F
authors.lastname: Schreiner
authors.affiliation: Department of Radiology, Children's Hospital, University of Bonn, 53113 Bonn, Germany. mark.born@ukb.uni-bonn.de.
authors.forename: Mark
authors.initials: M
authors.lastname: Born
authors.affiliation: Department of Neonatology, Children's Hospital, University of Bonn, 53113 Bonn, Germany. peter.bartmann@ukb.uni-bonn.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Bartmann
authors.affiliation: Paediatric Endocrinology Division, Children's Hospital, University of Bonn, 53113 Bonn, Germany. joachim.woelfle@ukb.uni-bonn.de.
authors.forename: Joachim
authors.initials: J
authors.lastname: Woelfle
mesh_terms: D015502:Absorptiometry, Photon; D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D007328:Insulin / Q000097:blood; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D015596:Nutrition Assessment; D012189:Retrospective Studies; D015430:Weight Gain
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D007328:Insulin
keywords: body composition; early nutrition; preterm