title: Abnormal functional connectivity strength in patients with adolescent-onset schizophrenia: a resting-state fMRI study.
abstract: Structural and functional abnormalities were reported in the brain of patients with adolescent-onset schizophrenia (AOS). However, evidence of abnormal functional connectivity of the brain in AOS patients is limited. Thus, we analyzed the resting-state functional magnetic resonance scans of 48 drug-naive AOS patients and 31 healthy controls to determine their functional connectivity strength (FCS) and examined if FCS abnormalities were correlated with clinical characteristics. Compared with healthy controls, AOS patients showed significantly increased FCS in the left cerebellum VI and right inferior frontal gyrus/insula. A positive correlation was observed between FCS values in the right inferior frontal gyrus/insula and general psychopathology scores of positive and negative syndrome scale. Results suggest that functional connectivity pattern is disrupted in drug-naive AOS patients. The FCS values in this abnormal region have potential for evaluating the disease severity.
authors.affiliation: Hunan Key Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center On Mental Health Disorders, National Technology Institute On Mental Disorders, No. 139, Middle Renming Road, Changsha, 410011, People's Republic of China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
authors.forename: Luxian
authors.initials: L
authors.lastname: Lv
authors.affiliation: Hunan Key Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center On Mental Health Disorders, National Technology Institute On Mental Disorders, No. 139, Middle Renming Road, Changsha, 410011, People's Republic of China.
authors.forename: Renrong
authors.initials: R
authors.lastname: Wu
authors.affiliation: Hunan Key Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center On Mental Health Disorders, National Technology Institute On Mental Disorders, No. 139, Middle Renming Road, Changsha, 410011, People's Republic of China. zhaojingpingcsu@163.com.|Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China. zhaojingpingcsu@163.com.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Hunan Key Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center On Mental Health Disorders, National Technology Institute On Mental Disorders, No. 139, Middle Renming Road, Changsha, 410011, People's Republic of China. guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000503:physiopathology*
keywords: Adolescent-onset schizophrenia; Functional connectivity strength; Resting-state functional magnetic resonance