title: Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity.
abstract: We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug toxicity and expanding the repertoire of albumin technology available for cancer therapy.
authors.affiliation: The First Affiliated Hospital, School of Medicine; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Hangxiang
authors.identifier: http://orcid.org/0000-0001-6370-9728
authors.initials: H
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital, School of Medicine; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Jiaping
authors.initials: J
authors.lastname: Wu
authors.affiliation: The First Affiliated Hospital, School of Medicine; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: The First Affiliated Hospital, School of Medicine; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Xie
authors.affiliation: College of Life Sciences, Huzhou University, Huzhou, 313000, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Applied Engineering, Zhejiang Economic and Trade Polytechnic, Hangzhou, 310018, P. R. China. dyh@zjiet.edu.cn.
authors.forename: Yuehan
authors.initials: Y
authors.lastname: Dong
mesh_terms: D000418:Albumins / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007275:Injections, Intravenous; D008453:Maytansine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000418:Albumins; D000972:Antineoplastic Agents, Phytogenic; D008453:Maytansine