title: Adult Neuroblastoma-Case Report and Literature Review.
abstract: Neuroblastoma is the most common solid malignant neoplasm in the paediatric age group; accounting for 7% of all childhood malignancies, but neuroblastoma in adult, is a rare occurrence, finding mention in aeons of medical literature with an overall incidence of 1 in 10 million adults/year. We report the case of a 24-year-old male patient presenting with the complaints of progressive abdominal distention of 2 months duration. Multiple Detector Computed Tomography (MD-CT) of abdomen revealed a huge enhancing mass in the retroperitoneum abutting the left kidney, and a subsequent CT-guided biopsy and immunohistochemistry confirmed the diagnosis of ganglioneuroblastoma. The patient was administered 3-cycles of neo-adjuvant chemotherapy with ifosphamide, carboplatin and etoposide (ICE-chemotherapy) and subsequently 3 more cycles of chemotherapy post surgery, followed by radiation. The rarity of this neoplasm in adults accounts for the lack of standardized staging and treatment protocols and the dismal prognosis even with aggressive multimodal treatment. We report this case because of its extreme rarity, and its tendency for capricious behavior.
authors.affiliation: Consultant Pathologist and Haematopathologist, Department of Pathology and Haematopathology, Vedant Multispeciality Hospital , Thane, Maharashtra, India .
authors.forename: Vishwapriya Mahadev
authors.initials: VM
authors.lastname: Godkhindi
authors.affiliation: Consultant Oncologist and Head, Department of Oncology, Saifee Hospital , Mumbai, Maharashtra, India .
authors.forename: Maheboob M
authors.initials: MM
authors.lastname: Basade
authors.affiliation: Consultant Oncosurgeon, Department of Oncosurgery, Saifee Hospital , Mumbai, Maharashtra, India .
authors.forename: Kamran
authors.initials: K
authors.lastname: Khan
authors.affiliation: Consultant Oncopathologist, Department of Pathology, Saifee Hospital , Mumbai, Maharashtra, India .
authors.forename: Kiran
authors.initials: K
authors.lastname: Thorat
keywords: Ganglioneuroblastoma; Neuroblastic tumours; Retroperitoneal mass