title: Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System.
abstract: We discuss the recent finding by Mizishima's group regarding the role of the autophagy-related conjugation system in mediating the closure of autophagosomes and its implication in the study of autophagy in mammalian cells. The study not only shows a novel function of the autophagy-related conjugation system but also indicates that mammalian cells are capable of generating autophagosomes even without it.
authors.affiliation: From the Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Saito
authors.affiliation: From the Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark. sadoshju@njms.rutgers.edu.
authors.forename: Junichi
authors.initials: J
authors.lastname: Sadoshima
mesh_terms: D000818:Animals; D000071182:Autophagosomes / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D000071183:Autophagy-Related Proteins / Q000502:physiology*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000502:physiology
chemical_list: D000071183:Autophagy-Related Proteins; D008869:Microtubule-Associated Proteins