title: Mortality of Adult Critically Ill Subjects With Cancer.
abstract: BACKGROUND
  Cancer patients may require intensive care support for postoperative care, complications associated with underlying malignancy, or toxicities related to cancer therapy. The higher mortality rates found in this population than in the population of ICU patients without cancer may be attributable to confounding due to a higher prevalence of multiple organic dysfunctions at ICU admission in patients with malignancy; however, data regarding this hypothesis are scarce. Accordingly, we performed the present study to compare the crude and propensity score-matched mortality rates between adult subjects with and without cancer admitted to a mixed medical-surgical ICU.
  
  
  METHODS
  We conducted a retrospective analysis of a comprehensive longitudinal ICU database in a tertiary referral hospital in Southern Brazil. All adult subjects who were admitted to the ICU from January 2008 to December 2014 were evaluated. Crude and propensity score-matched all-cause 30-d mortality rates of critically ill subjects with cancer were compared with those of critically ill subjects without cancer.
  
  
  RESULTS
  A total of 4,221 subjects were evaluated. The survival analysis revealed that the crude mortality rate was higher among subjects with cancer than among subjects without cancer (18.7% vs 10.2%,P< .001). However, after matching by propensity score, the 30-d mortality rates of subjects with and without cancer were similar (18.5% vs 15.2%,P= .17).
  
  
  CONCLUSIONS
  The present study failed to show an association between malignancy and all-cause 30-d mortality rate in adult subjects admitted to a mixed medical-surgical ICU. The propensity score-matched analysis showed no evidence of excessive mortality due to cancer diagnosis.
authors.affiliation: ICU.
authors.forename: Regis Goulart
authors.initials: RG
authors.lastname: Rosa
authors.affiliation: ICU.
authors.forename: Tulio Frederico
authors.initials: TF
authors.lastname: Tonietto
authors.affiliation: Department of Internal Medicine.
authors.forename: Bruno Achutti
authors.initials: BA
authors.lastname: Duso
authors.affiliation: ICU.
authors.forename: Juçara Gasparetto
authors.initials: JG
authors.lastname: Maccari
authors.affiliation: ICU.|ICU, Santa Casa de Misericordia Hospital, Porto Alegre, Brazil.
authors.forename: Roselaine Pinheiro
authors.initials: RP
authors.lastname: de Oliveira
authors.affiliation: ICU.
authors.forename: William
authors.initials: W
authors.lastname: Rutzen
authors.affiliation: ICU.
authors.forename: Laura
authors.initials: L
authors.lastname: Madeira
authors.affiliation: ICU.
authors.forename: Aline
authors.initials: A
authors.lastname: Ascoli
authors.affiliation: Department of Internal Medicine.
authors.forename: Rachel
authors.initials: R
authors.lastname: Hessler
authors.affiliation: Department of Palliative Care.
authors.forename: Paola
authors.initials: P
authors.lastname: Morandi
authors.affiliation: Department of Palliative Care.
authors.forename: Ricardo Viegas
authors.initials: RV
authors.lastname: Cremonese
authors.affiliation: ICU, Ernesto Dornelles Hospital, Porto Alegre, Brazil.
authors.forename: Felippe Leopoldo Dexheimer
authors.initials: FLD
authors.lastname: Neto
authors.affiliation: Rapid Response Team, Hospital Moinhos de Vento, Porto Alegre, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Tagliari
authors.affiliation: ICU.
authors.forename: Patrícia
authors.initials: P
authors.lastname: de Campos Balzano
authors.affiliation: ICU.
authors.forename: José Hervê Diel
authors.initials: JHD
authors.lastname: Barth
authors.affiliation: ICU cassiano.rush@gmail.com.|Department of Internal Medicine, UFCSPA Medical School, Porto Alegre, Brazil.
authors.forename: Cassiano
authors.initials: C
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D002423:Cause of Death; D016638:Critical Illness / Q000401:mortality*; D016208:Databases, Factual; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality*; D057216:Propensity Score; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: cancer; critical care; critical illness; mortality; prognosis