title: Low salivary resolvin D1 to leukotriene B4ratio predicts carotid intima media thickness: A novel biomarker of non-resolving vascular inflammation.
abstract: Background Different lipid mediators may have opposing effects on vascular inflammation. For example, whereas leukotriene B4(LTB4) transduces inflammation, resolvin D1 (RvD1), which is synthesized from the omega-3 fatty acid docosahexaenoic acid, facilitates the resolution of inflammation. The aim of this study was to determine the association of the RvD1/LTB4ratio with subclinical atherosclerosis. Methods Saliva samples and ultrasound measurements of the intima media thickness of the carotid artery was obtained for 254 participants. The lipid mediators RvD1 and LTB4were measured by enzyme-linked immunosorbent assay. Results Participants with a salivary RvD1/LTB4ratio >1 had a significantly lower intima media thickness than those in whom LTB4prevailed. The salivary RvD1/LTB4 ratio independently predicted carotid intima media thickness. Conclusions The ratio between the proresolving and proinflammatory salivary lipid mediators RvD1 and LTB4may serve as a biomarker of non-resolving inflammation and its relation to intima media thickness in cardiovascular disease.
authors.affiliation: 1 Department of Medicine, Karolinska Institutet, Sweden.
authors.forename: Silke
authors.initials: S
authors.lastname: Thul
authors.affiliation: 2 INSERM U1116, Université de Lorraine Nancy, France.
authors.forename: Carlos
authors.initials: C
authors.lastname: Labat
authors.affiliation: 3 Telomere Cardiology Center, Algeria.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Temmar
authors.affiliation: 2 INSERM U1116, Université de Lorraine Nancy, France.|4 Centre Hospitalier Régional Universitaire de Nancy, France.
authors.forename: Athanase
authors.initials: A
authors.lastname: Benetos
authors.affiliation: 1 Department of Medicine, Karolinska Institutet, Sweden.|2 INSERM U1116, Université de Lorraine Nancy, France.|4 Centre Hospitalier Régional Universitaire de Nancy, France.|5 Department of Cardiology, Karolinska University Hospital, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Bäck
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D004281:Docosahexaenoic Acids / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis*; D007975:Leukotriene B4 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012463:Saliva / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; C518399:resolvin D1; D007975:Leukotriene B4; D004281:Docosahexaenoic Acids
keywords: Atherosclerosis; eicosanoids; lipid mediators; resolution of inflammation