title: An RB insensitive to CDK regulation.
abstract: The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays tumor cell growth. This novel mechanism of RB regulation opens up a window for developing new cancer drug treatments for tumors harboring high CDK-Cyclin activity and a wild-type RB gene.
authors.affiliation: Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF) , Barcelona, Spain.
authors.forename: Manel
authors.initials: M
authors.lastname: Joaquin
authors.affiliation: Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF) , Barcelona, Spain.
authors.forename: Eulàlia
authors.initials: E
authors.lastname: de Nadal
authors.affiliation: Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF) , Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Posas
keywords: CDK; Cellular stress; p38; retinoblastoma; tumor suppressor