title: Priming nanoparticle-guided diagnostics and therapeutics towards human organs-on-chips microphysiological system.
abstract: Nanotechnology and bioengineering have converged over the past decades, by which the application of multi-functional nanoparticles (NPs) has been emerged in clinical and biomedical fields. The NPs primed to detect disease-specific biomarkers or to deliver biopharmaceutical compounds have beena validated in conventional in vitro culture models including two dimensional (2D) cell cultures or 3D organoid models. However, a lack of experimental models that have strong human physiological relevance has hampered accurate validation of the safety and functionality of NPs. Alternatively, biomimetic human "Organs-on-Chips" microphysiological systems have recapitulated the mechanically dynamic 3D tissue interface of human organ microenvironment, in which the transport, cytotoxicity, biocompatibility, and therapeutic efficacy of NPs and their conjugates may be more accurately validated. Finally, integration of NP-guided diagnostic detection and targeted nanotherapeutics in conjunction with human organs-on-chips can provide a novel avenue to accelerate the NP-based drug development process as well as the rapid detection of cellular secretomes associated with pathophysiological processes.
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712 USA.
authors.forename: Jin-Ha
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712 USA.
authors.forename: Jaewon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712 USA.
authors.forename: Woojung
authors.initials: W
authors.lastname: Shin
authors.affiliation: Department of Chemical & Biomolecular Engineering, Sogang University, Seoul, 04107 Republic of Korea ; Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul, 04107 Republic of Korea.
authors.forename: Jeong-Woo
authors.initials: JW
authors.lastname: Choi
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712 USA ; School of Medicine, Pusan National University, Yangsan, 50612 Republic of Korea.
authors.forename: Hyun Jung
authors.identifier: 0000-0001-5342-2870
authors.initials: HJ
authors.lastname: Kim
keywords: Diagnostics; Microphysiological system; Nano-biotechnology; Nanoparticle; Organs-on-chips; Therapeutics