title: The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis.
abstract: Background. There have been inconsistent reports on the prevalence and pathogenicity of anti-Aquaporin 4 (AQP4) in patients presented with idiopathic inflammatory demyelinating diseases (IIDDs).Objective. To estimate the prevalence of anti-AQP4 antibody in patients with IIDDs presented to University Malaya Medical Centre in terms of patients' clinical and radiological presentations and prognoses.Methods. Retrospective data review of IIDDs patients presented from 2005 to 2015. Patients were classified into classical multiple sclerosis (CMS), opticospinal (OS) presentation, optic neuritis (ON), transverse myelitis (TM), brainstem syndrome (BS), and tumefactive MS. Anti-Aquaporin 4 antibody was tested using the Indirect Immunofluorescence Test (IIFT) cell-based assay. Statistical analysis was done using the SPSS version 20.Results. Anti-AQP4 antibody was detected in 53% of patients presented with IIDDs. CMS was more common in the seronegative group, 27/47 (57.45%;p< 0.001). Conversely, OS involvement was more common in the seropositive group, 26/53 (49.06%;p< 0.001). Longitudinally extensive spinal cord lesions (LESCLs) on MRI were also more common in the seropositive group, 29/40 (72.50%;p= 0.004). Only 2/40 (5.00%) had MRI evidence of patchy or multiple short-segment spinal cord lesions in the AQP4-positive group (p= 0.003). The relapse rate and Expanded Disability Status Scale (EDSS) were also higher in the seropositive group (5.43 versus 3.17,p= 0.005; 4.07 versus 2.51,p= 0.006, resp.). Typical clinical presentations that defined NMO were also seen in the seronegative patients, but in a lower frequency.Conclusion. Our cohort of patients had a higher prevalence of seropositivity of anti-AQP4 antibody as compared to those in Western countries. This was also associated with a more typical presentation of opticospinal involvement with LESCLs on MRI, a higher rate of relapse, and EDSS.
authors.affiliation: Division of Neurology, Department of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: S
authors.identifier: 0000-0002-6730-678X
authors.initials: S
authors.lastname: Abdullah
authors.affiliation: Department of Medical Microbiology, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: W F
authors.identifier: 0000-0003-1082-1956
authors.initials: WF
authors.lastname: Wong
authors.affiliation: Division of Neurology, Department of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: C T
authors.initials: CT
authors.lastname: Tan