title: Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation.
abstract: A rapid rise in obesity, as well as physical inactivity, in industrialized countries is associated with fructose-consumption-mediated metabolic syndrome having a strong association with cardiovascular disease. Although insulin resistance is thought to be at the core, visceral obesity, hypertension, and hypertriglyceridemia are also considered important components of this metabolic disorder. In addition, various other abnormalities such as inflammation, oxidative stress, and elevated levels of uric acid are also part of this syndrome. Lifestyle changes through improved physical activity, as well as nutrition, are important approaches to minimize metabolic syndrome and its deleterious effects.
authors.affiliation: a Universidade Nove de Julho, Diretoria de Mestrado, Av. Francisco Matatazzo, 612, 10 andar, Centro de Pos Graduacao Stricto Sensu, Barra Funda, Sao Paulo, Brazil.
authors.forename: Nathalia
authors.initials: N
authors.lastname: Bernardes
authors.affiliation: b Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
authors.forename: Prathapan
authors.initials: P
authors.lastname: Ayyappan
authors.affiliation: a Universidade Nove de Julho, Diretoria de Mestrado, Av. Francisco Matatazzo, 612, 10 andar, Centro de Pos Graduacao Stricto Sensu, Barra Funda, Sao Paulo, Brazil.
authors.forename: Katia
authors.initials: K
authors.lastname: De Angelis
authors.affiliation: b Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
authors.forename: Ashim
authors.initials: A
authors.lastname: Bagchi
authors.affiliation: b Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
authors.forename: Gauri
authors.initials: G
authors.lastname: Akolkar
authors.affiliation: a Universidade Nove de Julho, Diretoria de Mestrado, Av. Francisco Matatazzo, 612, 10 andar, Centro de Pos Graduacao Stricto Sensu, Barra Funda, Sao Paulo, Brazil.
authors.forename: Danielle
authors.initials: D
authors.lastname: da Silva Dias
authors.affiliation: c Laboratory of Cardiovascular Physiology, Institute of Basic Health Science (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Adriane
authors.initials: A
authors.lastname: Belló-Klein
authors.affiliation: b Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
authors.forename: Pawan K
authors.initials: PK
authors.lastname: Singal
mesh_terms: D000818:Animals; D001794:Blood Pressure; D000073417:Dietary Sugars / Q000009:adverse effects*; D005632:Fructose / Q000009:adverse effects*; D000070497:Healthy Lifestyle; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D033461:Hyperuricemia / Q000097:blood / Q000209:etiology / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D018836:Inflammation Mediators / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D018384:Oxidative Stress; D011379:Prognosis; D012307:Risk Factors; D040242:Risk Reduction Behavior; D014527:Uric Acid / Q000097:blood
chemical_list: D000073417:Dietary Sugars; D018836:Inflammation Mediators; D014527:Uric Acid; D005632:Fructose
keywords: activité physique; hypertension; inflammation; metabolic syndrome; oxidative stress; physical activity; stress oxydatif; syndrome métabolique