title: Paediatric Bone and Joint Infections in French Guiana: A 6 Year Retrospective Review.
abstract: The epidemiology of paediatric bone and joint infections from South America is poorly known. We herein report a retrospective study conducted in whole French Guiana from January 2010 to December 2015. Medical charts of 55 previously healthy children were analysed, identifying 27 with osteomyelitis, 22 with septic arthritis and 6 with multifocal infections and/or osteoarthritis. The male:female ratio was 2.2:1, and the mean age was 7.5 years. Eighty percent children were ≥36 months old who had predominantly osteomyelitis related to methicillin-susceptible Staphylococcus aureus (p < 0.05) in the course of neglected skin infections. Five children presented with multi-systemic infections resulting in one fatality, mainly caused by S. aureus producing Panton-Valentine leucocidin (p < 0.01). In contrast, children aged 6-36 months had more likely culture-negative infections (p < 0.05), septic arthritis and mild clinical and biological features. Further prospective studies are required to better guide rational diagnostic and therapeutic strategies.
authors.affiliation: Department of Pediatrics, Andrée Rosemon Hospital, French Guiana, Cayenne, France.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Osei
authors.affiliation: URMITE "Research Unit on Infectious and Emerging Diseases", Inserm 1095, CNRS 7278, IRD 198, UMR 63, Institut Hospitalo-Universitaire Méditerranée-Infection, APHM Public Hospitals, Aix-Marseille University, Marseille, France.|Department of Accident and Emergency, Andrée Rosemon Hospital, Cayenne, French Guiana, France.
authors.forename: Nawal
authors.initials: N
authors.lastname: El Houmami
authors.affiliation: Department of Pediatric Emergency Medicine, North Hospital, Marseille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Minodier
authors.affiliation: Department of Pediatric Surgery, Andrée Rosemon Hospital, French Guiana, Cayenne, France.
authors.forename: Anicet
authors.initials: A
authors.lastname: Sika
authors.affiliation: Department of Pediatric Surgery, Andrée Rosemon Hospital, French Guiana, Cayenne, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Basset
authors.affiliation: URMITE "Research Unit on Infectious and Emerging Diseases", Inserm 1095, CNRS 7278, IRD 198, UMR 63, Institut Hospitalo-Universitaire Méditerranée-Infection, APHM Public Hospitals, Aix-Marseille University, Marseille, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Seligmann
authors.affiliation: Department of Public Health, Inserm CIC 1424, Andrée Rosemon Hospital, Cayenne, French Guiana, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Terraz
authors.affiliation: Department of Microbiology, Andrée Rosemon Hospital, Cayenne, French Guiana, France.
authors.forename: Magalie
authors.initials: M
authors.lastname: Demar
authors.affiliation: Department of Pediatrics, Centre Médico-chirurgical de Kourou, Kourou, French Guiana, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Pochard
authors.affiliation: Department of Pediatrics, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Clouzeau
authors.affiliation: URMITE "Research Unit on Infectious and Emerging Diseases", Inserm 1095, CNRS 7278, IRD 198, UMR 63, Institut Hospitalo-Universitaire Méditerranée-Infection, APHM Public Hospitals, Aix-Marseille University, Marseille, France.
authors.forename: Pierre-Edouard
authors.initials: PE
authors.lastname: Fournier
authors.affiliation: Department of Pediatrics, Andrée Rosemon Hospital, French Guiana, Cayenne, France.
authors.forename: Narcisse
authors.initials: N
authors.lastname: Elenga
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D001427:Bacterial Toxins; D002648:Child; D002675:Child, Preschool; D005098:Exotoxins; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007956:Leukocidins; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin
keywords: French Guiana; Kingella kingae; Panton-Valentine leucocidin; Staphylococcus aureus; osteoarticular infections; paediatrics