title: Cell Therapies in Cardiomyopathy: Current Status of Clinical Trials.
abstract: Because the human heart has limited potential for regeneration, the loss of cardiomyocytes during cardiac myopathy and ischaemic injury can result in heart failure and death. Stem cell therapy has emerged as a promising strategy for the treatment of dead myocardium, directly or indirectly, and seems to offer functional benefits to patients. The ideal candidate donor cell for myocardial reconstitution is a stem-like cell that can be easily obtained, has a robust proliferation capacity and a low risk of tumour formation and immune rejection, differentiates into functionally normal cardiomyocytes, and is suitable for minimally invasive clinical transplantation. The ultimate goal of cardiac repair is to regenerate functionally viable myocardium after myocardial infarction (MI) to prevent or heal heart failure. This review provides a comprehensive overview of treatment with stem-like cells in preclinical and clinical studies to assess the feasibility and efficacy of this novel therapeutic strategy in ischaemic cardiomyopathy.
authors.affiliation: Cellular Biomedicine Group, 333 Guiping Road, Shanghai 200233, China; Cellular Biomedicine Group, 19925 Stevens Creek Blvd, Suite 100, Cupertino, CA 95014, USA.
authors.forename: Ming
authors.identifier: 0000-0002-6088-8780
authors.initials: M
authors.lastname: Hao
authors.affiliation: Cellular Biomedicine Group, 333 Guiping Road, Shanghai 200233, China; Cellular Biomedicine Group, 19925 Stevens Creek Blvd, Suite 100, Cupertino, CA 95014, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Wang
authors.affiliation: Cellular Biomedicine Group, 333 Guiping Road, Shanghai 200233, China; Cellular Biomedicine Group, 19925 Stevens Creek Blvd, Suite 100, Cupertino, CA 95014, USA.
authors.forename: Wen
authors.identifier: 0000-0003-3215-3020
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000628:therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends*; D013234:Stem Cells / Q000166:cytology