title: Modulation of Human Immune Response by Fungal Biocontrol Agents.
abstract: Although the vast majority of biological control agents is generally regarded as safe for humans and environment, the increased exposure of agriculture workers, and consumer population to fungal substances may affect the immune system. Those compounds may be associated with both intense stimulation, resulting in IgE-mediated allergy and immune downmodulation induced by molecules such as cyclosporin A and mycotoxins. This review discusses the potential effects of biocontrol fungal components on human immune responses, possibly associated to infectious, inflammatory diseases, and defective defenses.
authors.affiliation: Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz Ilhéus, Brazil.
authors.forename: Cibele
authors.initials: C
authors.lastname: Konstantinovas
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa Viçosa, Brazil.
authors.forename: Tiago A
authors.initials: TA
authors.lastname: de Oliveira Mendes
authors.affiliation: Biologia Celular Parasitária, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz Salvador, Brazil.
authors.forename: Marcos A
authors.initials: MA
authors.lastname: Vannier-Santos
authors.affiliation: Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz Ilhéus, Brazil.
authors.forename: Jane
authors.initials: J
authors.lastname: Lima-Santos
keywords: biofungicide; biological control; immunomodulation; spores