title: Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation inob/oband diet-induced obese mice.
abstract: The beneficial actions of n-3 fatty acids on obesity-induced insulin resistance and inflammation have been related to the synthesis of specialized proresolving lipid mediators (SPMs) like resolvins. The aim of this study was to evaluate the ability of one of these SPMs, maresin 1 (MaR1), to reverse adipose tissue inflammation and/or insulin resistance in two models of obesity: diet-induced obese (DIO) mice and genetic (ob/ob)obese mice. In DIO mice, MaR1 (2 μg/kg; 10 d) reduced F4/80-positive cells and expression of the proinflammatory M1 macrophage phenotype markerCd11cin white adipose tissue (WAT). Moreover, MaR1 decreasedMcp-1, Tnf-α, andIl-1βexpression, upregulated adiponectin andGlut-4, and increased Akt phosphorylation in WAT. MaR1 administration (2 μg/kg; 20 d) toob/obmice did not modify macrophage recruitment but increased the M2 macrophage markersCd163andIl-10.MaR1 reducedMcp-1,Tnf-α,Il-1β, andDpp-4and increased adiponectin gene expression in WAT. MaR1 treatment also improved the insulin tolerance test ofob/obmice and increased Akt and AMPK phosphorylation in WAT. These data suggest that treatment with MaR1 can counteract the dysfunctional inflamed WAT and could be useful to improve insulin sensitivity in murine models of obesity.-Martínez-Fernández, L., González-Muniesa, P., Laiglesia, L. M., Sáinz, N., Prieto-Hontoria, P. L., Escoté, X., Odriozola, L., Corrales, F. J., Arbones-Mainar, J. M., Martínez, J. A., Moreno-Aliaga, M. J. Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation inob/oband diet-induced obese mice.
authors.affiliation: Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.|Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
authors.forename: Leyre
authors.initials: L
authors.lastname: Martínez-Fernández
authors.affiliation: Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.|Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.|Center of Biomedical Research Network Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.|Health Research Institute of Navarra (IDISNA), Pamplona, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: González-Muniesa
authors.affiliation: Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.|Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Laiglesia
authors.affiliation: Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
authors.forename: Neira
authors.initials: N
authors.lastname: Sáinz
authors.affiliation: Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Prieto-Hontoria
authors.affiliation: Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Escoté
authors.affiliation: Proteomics and Bioinformatics Unit, Center.
authors.forename: Leticia
authors.initials: L
authors.lastname: Odriozola
authors.affiliation: Proteomics and Bioinformatics Unit, Center.|Division of Hepatology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Corrales
authors.affiliation: Center of Biomedical Research Network Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.|Adipocyte and Fat Biology Laboratory (AdipoFat), Instituto de Investigacion Sanitaria Aragon, Instituto Aragonés de Ciencias de la Salud, Unidad de Investigación Traslacional, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Arbones-Mainar
authors.affiliation: Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.|Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.|Center of Biomedical Research Network Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.|Health Research Institute of Navarra (IDISNA), Pamplona, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Martínez
authors.affiliation: Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain; mjmoreno@unav.es.|Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.|Center of Biomedical Research Network Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.|Health Research Institute of Navarra (IDISNA), Pamplona, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Moreno-Aliaga
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D004032:Diet; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D016753:Interleukin-10 / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism*
chemical_list: C535211:7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid; C556062:IL10 protein, mouse; D016753:Interleukin-10; D004281:Docosahexaenoic Acids
keywords: DHA; adipokines; glucose metabolism; macrophages; n-3 PUFAs derivatives