title: The effect of implementing an automated oxygen control on oxygen saturation in preterm infants.
abstract: OBJECTIVE
  To evaluate the effect of implementing automated oxygen control as routine care in maintaining oxygen saturation (SpO2) within target range in preterm infants.
  
  
  METHODS
  Infants <30 weeks gestation in Leiden University Medical Centre before and after the implementation of automated oxygen control were compared. The percentage of time spent with SpO2within and outside the target range (90-95%) was calculated. SpO2values were collected every minute and included for analysis when infants received extra oxygen.
  
  
  RESULTS
  In a period of 9 months, 42 preterm infants (21 manual, 21 automated) were studied. In the automated period, the median (IQR) time spent with SpO2within target range increased (manual vs automated: 48.4 (41.5-56.4)% vs 61.9 (48.5-72.3)%; p<0.01) and time SpO2>95% decreased (41.9 (30.6-49.4)% vs 19.3 (11.5-24.5)%; p<0.001). The time SpO2<90% increased (8.6 (7.2-11.7)% vs 15.1 (14.0-21.1)%; p<0.0001), while SpO2<80% was similar (1.1 (0.4-1.7)% vs 0.9 (0.5-2.1)%; ns).
  
  
  CONCLUSIONS
  During oxygen therapy, preterm infants spent more time within the SpO2target range after implementation of automated oxygen control, with a significant reduction in hyperoxaemia, but not hypoxaemia.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: H A
authors.initials: HA
authors.lastname: Van Zanten
authors.affiliation: Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: K L A M
authors.initials: KLAM
authors.lastname: Kuypers
authors.affiliation: Neonatal Unit, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK.
authors.forename: B J
authors.initials: BJ
authors.lastname: Stenson
authors.affiliation: Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic.
authors.forename: T E
authors.initials: TE
authors.lastname: Bachman
authors.affiliation: Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.|TiCC, Tilburg University, Tilburg, The Netherlands.
authors.forename: S C
authors.initials: SC
authors.lastname: Pauws
authors.affiliation: Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: A B
authors.initials: AB
authors.lastname: Te Pas
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D007442:Intubation, Intratracheal; D008991:Monitoring, Physiologic; D063087:Noninvasive Ventilation; D010092:Oximetry; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D010102:Oxygen Inhalation Therapy; D011446:Prospective Studies
chemical_list: D010100:Oxygen
keywords: Hyperoxaemia; Hypoxaemia; Oxygen; Preterm infant