title: Role of Hypoxia-Inducible Factors in the Development of Liver Fibrosis.
abstract: Liver fibrosis remains a significant clinical problem in the United States and throughout the world. Although important advances in the understanding of this disease have been made, no effective pharmacologic agents have been developed that directly prevent or reverse the fibrotic process. Many of the successes in liver fibrosis treatment have been targeted toward treating the cause of fibrosis, such as the development of new antivirals that eradicate hepatitis virus. For many patients, however, this is not feasible, so a liver transplant remains the only viable option. Thus, there is a critical need to identify new therapeutic targets that will slow or reverse the progression of fibrosis in such patients. Research over the last 16 years has identified hypoxia-inducible factors (HIFs) as key transcription factors that drive many aspects of liver fibrosis, making them potential targets of therapy. In this review, we discuss the latest work on HIFs and liver fibrosis, including the cell-specific functions of these transcription factors in the development of liver fibrosis.
authors.affiliation: Department of Pharmacology and Toxicology, the Institute for Environmental Toxicology, and the Program in Cellular and Molecular Biology, Michigan State University, East Lansing, Michigan.
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Roth
authors.affiliation: Department of Pharmacology and Toxicology, the Institute for Environmental Toxicology, and the Program in Cellular and Molecular Biology, Michigan State University, East Lansing, Michigan.
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Copple
keywords: BDL, bile duct ligation; CCl4, carbon tetrachloride; Ccr, C-C chemokine receptor; FGF, fibroblast growth factor; HGF, hepatocyte growth factor; HIFs, hypoxia-inducible factors; HSC, hepatic stellate cell; Hepatic Stellate Cells; Hypoxia-Inducible Factors; Jmjd, Jumonji domain-containing; Kupffer Cells; Liver Fibrosis; PAI-1, plasminogen activator inhibitor-1; PDGF, platelet-derived growth factor; Rgs, regulator of G-protein signaling; TGF-β, transforming growth factor β; VEGF, vascular endothelial growth factor; α-SMA, α-smooth muscle actin