title: Deceased donor uterine transplantation.
abstract: OBJECTIVE
  To share our experience in performing the first-ever deceased-donor uterine transplant in the United States.
  
  
  METHODS
  This video uses an animation and footage from a uterine transplantation procedure to review the steps and techniques involved in performing a uterine transplant.
  
  
  METHODS
  Academic, multisite medical center.
  
  
  METHODS
  A reproductive-age patient with Mayer-Rokitansky-Kuster-Hauser syndrome.
  
  
  METHODS
  Transplantation of a viable uterus from a deceased donor.
  
  
  METHODS
  Assessment of posttransplantation uterine graft viability.
  
  
  RESULTS
  This video article describes the essential steps in the uterine transplant process, including selecting an appropriate donor with no history of infertility or uterine malformations. Furthermore, a deceased donor should exhibit brain death but not cardiac death. We also review our inclusion criteria for suitable recipients. In this video we outline the key steps in a uterine transplantation procedure and demonstrate footage from an actual transplant procedure. These steps include establishing bilateral end-to-side vascular anastomoses between the donor uterine artery and vein and the recipient's external iliac vessels. Once this has been completed and reperfusion noted of the donor uterus, connection to the recipient vaginal cuff is then performed.
  
  
  CONCLUSIONS
  Uterine transplantation, although currently experimental, has gained the potential to become the first true treatment for uterine factor infertility. This procedure can become a promising option for the approximately 1.5 million women worldwide for whom pregnancy is not possible because of the absence of the uterus or presence of a nonfunctional uterus. Deceased donor uterine transplantation will further serve to broaden accessibility for this procedure.
authors.affiliation: Obstetrics/Gynecology and Women's Health Institute, The Cleveland Clinic, Cleveland, Ohio. Electronic address: flycktr@ccf.org.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Flyckt
authors.affiliation: Obstetrics/Gynecology and Women's Health Institute, The Cleveland Clinic, Cleveland, Ohio.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kotlyar
authors.affiliation: Obstetrics/Gynecology and Women's Health Institute, The Cleveland Clinic, Cleveland, Ohio.
authors.forename: Sara
authors.initials: S
authors.lastname: Arian
authors.affiliation: Department of Transplant Surgery, Cleveland Clinic Florida, Weston, Florida.
authors.forename: Bijan
authors.initials: B
authors.lastname: Eghtesad
authors.affiliation: Obstetrics/Gynecology and Women's Health Institute, The Cleveland Clinic, Cleveland, Ohio.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Falcone
authors.affiliation: Department of Transplant Surgery, Cleveland Clinic Florida, Weston, Florida.
authors.forename: Andreas
authors.initials: A
authors.lastname: Tzakis
mesh_terms: D058489:46, XX Disorders of Sex Development / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D009095:Mullerian Ducts / Q000002:abnormalities* / Q000601:surgery; D016377:Organ Transplantation / Q000379:methods*; D014022:Tissue Survival; D016896:Treatment Outcome; D014599:Uterus / Q000637:transplantation*
keywords: Uterine factor infertility; deceased donor uterine transplant; reproductive transplant; uterine transplantation