title: Dedifferentiated Liposarcoma of the Esophagus: A Case Report and Selected Review of the Literature.
abstract: Soft tissue sarcomas of the esophagus represent an extremely rare cause of esophageal masses, and an even smaller proportion of these tumors represent dedifferentiated liposarcomas. We present a case of a 75-year-old gentleman presenting with dysphagia found to have a 5 cm pedunculated mass in the cervical esophagus, originating at the cricopharyngeus. This was found to have involvement limited to the superficial mucosa by endoscopic ultrasound, and the lesion was subsequently resected endoscopically. Pathology demonstrated an undifferentiated pleomorphic sarcoma later determined to represent dedifferentiated liposarcoma after fluorescencein situhybridization analysis. The patient received no additional adjuvant therapy and remains disease free 20 months from the procedure. While treatment experience is limited, our case demonstrates that in selected patients, sustained local control can be obtained without radical resection.
authors.affiliation: Departments of Internal Medicine, Clinic Mayo, Jacksonville, FL, USA; Departments of Oncology Radiation, Clinic Mayo, Jacksonville, FL, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Brett
authors.affiliation: Departments of Oncology Radiation, Clinic Mayo , Jacksonville, FL, USA.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Miller
authors.affiliation: Departments of Pathology, Clinic Mayo , Jacksonville, FL, USA.
authors.forename: Liuyan
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Departments of Gastroenterology, Clinic Mayo , Jacksonville, FL, USA.
authors.forename: Herbert C
authors.initials: HC
authors.lastname: Wolfsen
authors.affiliation: Departments of Oncology, Clinic Mayo , Jacksonville, FL, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Attia
authors.affiliation: Departments of Oncology Radiation, Clinic Mayo , Jacksonville, FL, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Hintenlang
authors.affiliation: Departments of Oncology Radiation, Clinic Mayo , Jacksonville, FL, USA.
authors.forename: Niveditha
authors.initials: N
authors.lastname: Jagadesh
authors.affiliation: Departments of Oncology Radiation, Clinic Mayo , Jacksonville, FL, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Miller
keywords: Dedifferentiated liposarcoma; Esophageal mass; Surgical resection; Undifferentiated pleomorphic sarcoma