title: Association of recently identified type 2 diabetes gene variants with Gestational Diabetes in Asian Indian population.
abstract: Earlier studies have provided evidence that the gestational diabetes mellitus (GDM) and Type 2 diabetes mellitus (T2DM) share common genetic background. A recent genome wide association study (GWAS) showed a strong association of six novel gene variants with T2DM among south Asians but not with Europeans. The aim of this study was to investigate whether these variants that confer susceptibility to T2DM in Asian Indian population also correlate with GDM in Asian Indian population. In addition to these novel variants, three T2DM associated SNPs that were previously identified by GWAS in Caucasian populations, which also showed association with T2DM in south Indian population in our previous study were also evaluated for their susceptibility to GDM in our population. The study groups comprised unrelated pregnant women with GDM (n = 518) and pregnant women with normal glucose tolerance (NGT) (n = 1220). A total of nine SNPs in or near nine loci, namely AP3S2 (rs2028299), BAZ1B (rs12056034), CDKN2A/B (rs7020996), GRB14 (rs3923113), HHEX (rs7923837), HMG20A (rs7178572), HNF4A (rs4812829), ST6GAL1 (rs16861329) and VPS26A (rs1802295) were genotyped using the MassARRAY system. Among these nine SNPs that previously showed an association with T2DM in Asian Indians, HMG20A (rs7178572) and HNF4A (rs4812829) gene variants showed a significant association with GDM. The risk alleles of rs7178572 in HMG20A and rs4812829 in HNF4A gene conferred 1.24 and 1.28 times higher risk independently and about 1.44 and 1.97 times increased susceptibility to GDM for one and two risk genotypes, respectively. We report that the HMG20A (rs7178572) and HNF4A (rs4812829) variants that have previously shown a strong association with T2DM in Asian Indians also contributes significant risk to GDM in this population. This is the first report of the association of HMG20A (rs7178572) and HNF4A (rs4812829) variants with GDM.
authors.affiliation: Madras Diabetes Research Foundation, No. 4, Conran Smith Road, Gopalapuram, Chennai, India.
authors.forename: Sekar
authors.initials: S
authors.lastname: Kanthimathi
authors.affiliation: Madras Diabetes Research Foundation, No. 4, Conran Smith Road, Gopalapuram, Chennai, India.|Division of Experimental Genetics, Sidra Medical and Research Center, Out-Patient Clinic, C6-73003, PO Box 26999, Al Luqta Street, Education City North Campus, Qatar Foundation, Doha, Qatar.
authors.forename: Manickam
authors.initials: M
authors.lastname: Chidambaram
authors.affiliation: Madras Diabetes Research Foundation, No. 4, Conran Smith Road, Gopalapuram, Chennai, India.
authors.forename: Dhanasekaran
authors.initials: D
authors.lastname: Bodhini
authors.affiliation: Madras Diabetes Research Foundation, No. 4, Conran Smith Road, Gopalapuram, Chennai, India.
authors.forename: Samuel
authors.initials: S
authors.lastname: Liju
authors.affiliation: SRC Diabetes Care Centre, Erode, India.
authors.forename: Aruyerchelvan
authors.initials: A
authors.lastname: Bhavatharini
authors.affiliation: Seethapathy Clinic and Hospital, Chennai, India.
authors.forename: Ram
authors.initials: R
authors.lastname: Uma
authors.affiliation: Madras Diabetes Research Foundation, No. 4, Conran Smith Road, Gopalapuram, Chennai, India.|Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non Communicable Diseases Prevention and Control, Chennai, India.
authors.forename: Ranjit Mohan
authors.initials: RM
authors.lastname: Anjana
authors.affiliation: Madras Diabetes Research Foundation, No. 4, Conran Smith Road, Gopalapuram, Chennai, India.|Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non Communicable Diseases Prevention and Control, Chennai, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
authors.affiliation: Madras Diabetes Research Foundation, No. 4, Conran Smith Road, Gopalapuram, Chennai, India. radharv@yahoo.co.in.
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Radha
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy
keywords: Asian Indian; GDM; GWAS; HMG20A (rs7178572); HNF4A (rs4812829); T2DM