title: IFNAR1 Degradation: A New Mechanism for Tumor Immune Evasion?
abstract: Type I interferons have been shown to play a major role in anti-cancer immunity. In this issue of Cancer Cell, Katlinski et al. describe tumor-induced degradation of type I interferon receptor IFNAR1 chain as a new immune-evasion mechanism in colorectal cancers. Stabilizing IFNAR1 inhibits tumor growth and improves immunotherapy efficacy.
authors.affiliation: Inflammatory Cell Dynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Romina E
authors.initials: RE
authors.lastname: Araya
authors.affiliation: Inflammatory Cell Dynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: rgoldszmid@mail.nih.gov.
authors.forename: Romina S
authors.initials: RS
authors.lastname: Goldszmid
mesh_terms: D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D019139:Tumor Escape
chemical_list: D007370:Interferon Type I