title: Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridine.
abstract: A post-synthetic reaction of 5-pivaloyloxymethyluridine (present in a support-bound RNA oligomer) with various nucleophilic reagents furnished efficiently the corresponding products bearing one of the tRNA wobble 5-methyluridines (mnm5U, cmnm5U, τm5U, nm5U, inm5U or cnm5U). The syntheses of oligoribonucleotides modified with inm5U and cnm5U are reported for the first time.
authors.affiliation: Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland. grazyna.leszczynska@p.lodz.pl.
authors.forename: Karolina
authors.identifier: http://orcid.org/0000-0001-8094-6741
authors.initials: K
authors.lastname: Bartosik
authors.affiliation: Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland. grazyna.leszczynska@p.lodz.pl.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Sochacka
authors.affiliation: Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland. grazyna.leszczynska@p.lodz.pl.
authors.forename: Grazyna
authors.identifier: http://orcid.org/0000-0002-6874-022X
authors.initials: G
authors.lastname: Leszczynska
mesh_terms: D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D009843:Oligoribonucleotides; C009182:ribothymidine; D012313:RNA; D014529:Uridine