title: Nonmotor symptoms in de novo Parkinson disease comparing to normal aging.
abstract: OBJECTIVE
  Nonmotor symptoms (NMSs) are common in Parkinson disease (PD), affecting patient's quality of life. The prevalence and domains of NMSs in untreated de novo PD remains unclear, especially comparing to normal aging. The objective was to determine NMSs in untreated de novo PD patients.
  
  
  METHODS
  We performed a cross-sectional study to evaluate the frequency and severity of NMSs in untreated de novo PD patients (n=71) and age-matched normal controls (n=60) using the Non-Motor Symptoms Scale (NMSS). The motor section of the Unified Parkisnon Disease Rating Scale (mUPDRS) and the Hoehn and Yahr (HY) stage were also obtained in PD patients RESULTS: The number of NMSs and the NMSS scores were significantly higher in the PD patients than in controls (p<0.001). There was no correlation of the NMSS scores with age and sex in both group and additionally with mUPDRS score and HY stage in PD patients group. Mood/cognition, attention/memory and gastrointestinal domains are the most frequent in PD patients and rarely seen in controls.
  
  
  CONCLUSIONS
  NMSs in untreated de novo PD patients are more prevalent and severe with different domain involvement comparing to normal aging.
authors.affiliation: Department of Neurology, University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia. Electronic address: petrabago@yahoo.com.
authors.forename: Petra
authors.initials: P
authors.lastname: Bago Rožanković
authors.affiliation: Department of Neurosurgery, University Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia.
authors.forename: Marjan
authors.initials: M
authors.lastname: Rožanković
authors.affiliation: Department of Neurology, University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia.
authors.forename: Lovorka
authors.initials: L
authors.lastname: Vučak Novosel
authors.affiliation: Department of Neurology, University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia.
authors.forename: Maristela
authors.initials: M
authors.lastname: Stojić
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D011788:Quality of Life; D012720:Severity of Illness Index; D012727:Sex Characteristics
keywords: Healthy controls; Non-motor symptoms; Non-motor symptoms scale; Parkinson disease