title: BDNF During Withdrawal.
abstract: Among the adaptations observed following drugs of abuse consumption, BDNF levels are widely altered in both brain and periphery. In this chapter, we first reviewed these adaptations in preclinical studies, in both juveniles and adult animals. A particular focus was made on protracted withdrawal as incubation is often associated with an increase in central BDNF levels. Then, we reported mixed results regarding the role of BDNF in drug-seeking behavior in animals as BDNF can either enhance reinstatement or have protective properties. Finally, we reviewed recent clinical studies that provide insight into the potential of BDNF to be a good biomarker of vulnerability to relapse.
authors.affiliation: Université Paris Descartes, Inserm U1124, CNRS ERL3649, Neuroplasticité et Thérapies des addictions, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Geoffroy
authors.affiliation: Université Paris Descartes, Inserm U1124, CNRS ERL3649, Neuroplasticité et Thérapies des addictions, Paris, France. Electronic address: florence.noble@parisdescartes.fr.
authors.forename: F
authors.initials: F
authors.lastname: Noble
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000037:antagonists & inhibitors / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000633:toxicity; D044127:Epigenesis, Genetic / Q000187:drug effects; D000431:Ethanol / Q000506:poisoning; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D013287:Illicit Drugs / Q000633:toxicity; D008562:Membrane Glycoproteins / Q000819:agonists* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D011110:Polymorphism, Genetic; D020813:Receptor, trkB / Q000819:agonists* / Q000378:metabolism; D055502:Secondary Prevention; D015398:Signal Transduction / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D019966:Substance-Related Disorders / Q000097:blood / Q000235:genetics / Q000378:metabolism / Q000628:therapy
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D000697:Central Nervous System Stimulants; D013287:Illicit Drugs; D008562:Membrane Glycoproteins; D000431:Ethanol; C579455:BDNF protein, human; D020813:Receptor, trkB; C000591259:tropomyosin-related kinase-B, human
keywords: Addiction; BDNF; Biomarker; Brain; Craving; Plasma; Withdrawal