title: Association of serum intact fibroblast growth factor 23 with left ventricular mass and different echocardiographic findings in patients on hemodialysis.
abstract: OBJECTIVE
  To determine the association of fibroblast growth factor 23 (FGF23) with left ventricular hypertrophy (LVH) through the assessment of left ventricular (LV) mass and left ventricular mass index (LVMI) in patients on hemodialysis, this study was done.
  
  
  METHODS
  All patients on hemodialysis who are older than 18 years and in whom hemodialysis vintage was at least 6 months were enrolled. All patients were on hemodialysis thrice a week for 4 h using low-flux dialysis filters, polysulfone membranes, reverse osmosis purified water, and bicarbonate-base hemodialysis solution. The exclusion criteria were any respiratory illness or pulmonary infection, cigarette smoking, and the presence of pericarditis or pericardial effusion. Additionally, patients with a known coronary artery disease, any form of cardiac arrhythmias, any cardiomyopathy or severe valvular heart disease diagnosed by echocardiography, acute congestive heart failure (CHF), and acute myocardial infarction were not included. Echocardiography was conducted by an experienced operator for all the enrolled patients using the ACUSON SC2000™ ultrasound system transducer (Siemens), with a frequency bandwidth of: 1.5-3.5 MHz. Patients were considered to have LVH if the LVMI was greater than 134 g/m2for men and greater than 110 g/m2for women.
  
  
  RESULTS
  A total of 61 patients (19 female and 42 male) were enrolled to the study. Mean (± SD) age of the patients was 59.6 ± 13.1 years. The median duration of hemodialysis was 23 (range: 6-120) months. The median predialysis level of FGF23 was 1,977 pg/mL (range: 155-8,870). LVH was seen in 73.8% of the patients (n = 45) and of them 66.7% were male. There was a statistically significant direct correlation between FGF23 and left ventricle diameter in end systole (LVDs) (r = 0.29,P= 0.027). However, the association of FGF23 with LV mass, LVMI, and left ventricular ejection fraction (LVEF) was not significant.
  
  
  CONCLUSIONS
  This study does not show the correlation between FGF23 and LV mass in stable hemodialysis patients.
authors.affiliation: Department of Nephrology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Amir Ahmad
authors.initials: AA
authors.lastname: Nassiri
authors.affiliation: Department of Nephrology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Monir Sadat
authors.initials: MS
authors.lastname: Hakemi
authors.affiliation: Department of Nephrology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Reza
authors.initials: R
authors.lastname: Safar-Pour
authors.affiliation: Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmadi
authors.affiliation: Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Maryam
authors.initials: M
authors.lastname: Tohidi
authors.affiliation: Department of Cardiology, Massih-Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Babak Sharif
authors.initials: BS
authors.lastname: Kashani
authors.affiliation: Research Center, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Esfehani
authors.affiliation: Department of Nephrology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of).
authors.forename: Soudabeh
authors.initials: S
authors.lastname: Alatab
keywords: echocardiography; fibroblast growth factor 23; hemodialysis; intact parathyroid hormone; left ventricular hypertrophy