title: [Histomorphometric evaluation of ridge preservation after molar tooth extraction].
abstract: To evaluate bone formation in human extraction sockets with absorbed surrounding walls augmented with Bio-Oss and Bio-Gide after a 6-month healing period by histologic and histomorphometric analyses.
  
  
  
  Six fresh molar tooth extraction sockets in 6 patients who required periodontally compromised moral tooth extraction were included in this study. The six fresh extraction sockets were grafted with Bio-Oss particle covered with Bio-Gide. The 2.8 mm×6.0 mm cylindric bone specimens were taken from the graft sites with aid of stent 6 months after the surgery. Histologic and histomorphometric analyses were performed.
  
  
  
  The histological results showed Bio-Oss particles were easily distinguished from the newly formed bone, small amounts of new bone were formed among the Bio-Oss particles, large amounts of connective tissue were found. Intimate contact between the newly formed bone and the small part of Bio-Oss particles was present. All the biopsy cylinders measurement demonstrated a high inter-individual variability in the percentage of the bone, connective tissues and Bio-Oss particles. The new bone occupied 11.54% (0-28.40%) of the total area; the connective tissues were 53.42% (34.08%-74.59%) and the Bio-Oss particles were 35.04% (13.92%-50.87%). The percentage of the particles, which were in contact with bone tissues, amounted to 20.13% (0-48.50%).
  
  
  
  Sites grafted with Bio-Oss particles covered with Bio-Gide were comprised of connective tissues and small amounts of newly formed bone surrounding the graft particles.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Zhan
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Hu
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
authors.forename: T
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhen
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
authors.forename: R F
authors.initials: RF
authors.lastname: Lu
mesh_terms: D001857:Bone Matrix / Q000033:anatomy & histology* / Q000187:drug effects / Q000254:growth & development*; D018786:Bone Substitutes / Q000627:therapeutic use; D003094:Collagen / Q000494:pharmacology* / Q000627:therapeutic use*; D003238:Connective Tissue / Q000033:anatomy & histology* / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D008903:Minerals / Q000494:pharmacology* / Q000627:therapeutic use*; D008963:Molar; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D014081:Tooth Extraction; D020390:Tooth Socket / Q000033:anatomy & histology* / Q000187:drug effects* / Q000254:growth & development* / Q000293:injuries; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals; D003094:Collagen