title: The serotonin transporter polymorphism (5-HTTLPR) and coping strategies influence successful emotion regulation in an acute stress situation: Physiological evidence.
abstract: Emotion regulation is an important everyday-life skill to reduce harm and stress. Consequently, research shows associations between psychopathologies and emotional dysregulation. The serotonin transporter polymorphism (5-HTTLPR) has repeatedly been associated to phenotypes and syndromes related to emotional dysregulation. However, there is no study showing any direct effects of 5-HTTLPR genotype and emotion regulation. Hence, the aim of the present study was to draw a link between 5-HTTLPR to emotion regulation.
  
  
  
  N=91 healthy participants filled in a coping questionnaire, provided gene samples and participated in an emotion regulation experiment. In a within-subject design they viewed emotional pictures and were either instructed to suppress their emotions or not. During the emotion regulation task, skin conductance responses (SCR) were recorded.
  
  
  
  Emotion regulation abilities measured by SCR were influenced by 5-HTTLPR and coping strategies, together explaining 30% of variance. S-allele carriers showed increased SCRs when watching aversive stimuli in the uninstructed condition. However, when receiving an emotion regulation instruction, they were able to downregulate their arousal resulting in comparable SCRs as observed in LL-carriers.
  
  
  
  This is the first study showing an impact of 5-HTTLPR on physiological emotion regulation. Results show that S-allele carriers have the same emotional arousal as L-allele carriers, when they get a supportive instruction to suppress unwanted feelings. These findings have implications for psychotherapeutic treatments.
authors.affiliation: Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany. Electronic address: Thomas.plieger@uni-bonn-diff.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Plieger
authors.affiliation: Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Melchers
authors.affiliation: Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany.
authors.forename: Annabel
authors.initials: A
authors.lastname: Vetterlein
authors.affiliation: Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany.
authors.forename: Janina
authors.initials: J
authors.lastname: Görtz
authors.affiliation: Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kuhn
authors.affiliation: Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany.
authors.forename: Melissa
authors.initials: M
authors.lastname: Ruppel
authors.affiliation: Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany; Center for Economics & Neuroscience (CENs), University of Bonn, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Reuter
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000328:Adult; D001143:Arousal / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005260:Female; D005712:Galvanic Skin Response / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D000068356:Self-Control; D013315:Stress, Psychological / Q000235:genetics / Q000503:physiopathology*; D055815:Young Adult
keywords: 5-HTTLPR/rs25531; Coping; Emotion regulation; Serotonin; Skin conductance response; Stress