title: Comparison between vaginal and sublingual misoprostol 50 µg for cervical ripening prior to induction of labor: randomized clinical trial.
abstract: OBJECTIVE
  To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6 h of administration.
  
  
  METHODS
  Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. Bishop score was assessed at the time of induction and 6 h after administration of 50 µg misoprostol. Analysis was made over difference in mean Bishop score of 2 points, using a standard deviation of 2, with 90% power, reaching a 95% confidence interval.
  
  
  RESULTS
  102 patients were studied, 51 received sublingual misoprostol, and 51 received vaginal misoprostol. There was a statistically significant difference in cervical modifications in global terms regardless of the administration route at 6 h (P < 0.05). When analyzing each group, there was no significant difference for the mean and standard deviation for Bishop score for sublingual and vaginal route (P = 0.761). There was no significant difference in terms of mode of delivery, Apgar score, cord pH, nor in the presence of complications.
  
  
  CONCLUSIONS
  There is no statistically significant difference in terms of administration route for cervical ripening using misoprostol 50 µg, whether it was sublingual or vaginal.
  
  
  BACKGROUND
  NCT02732522. Registry website: https://clinicaltrials.gov/ .
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay. acmaine@hotmail.com.|, Gabriel Pereira 2845, CP 11300, Montevideo, Uruguay. acmaine@hotmail.com.
authors.forename: Andrés
authors.initials: A
authors.lastname: Conde
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Ben
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay.
authors.forename: Josefina
authors.initials: J
authors.lastname: Tarigo
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay.
authors.forename: Santiago
authors.initials: S
authors.lastname: Artucio
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay.
authors.forename: Virginia
authors.initials: V
authors.lastname: Varela
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay.
authors.forename: Pamela
authors.initials: P
authors.lastname: Grimaldi
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay.
authors.forename: Claudio
authors.initials: C
authors.lastname: Sosa
authors.affiliation: Department of Obstetrics and Ginecology, Hospital Pereira Rossell, University of Uruguay, Bulevar Gral, Artigas 1550, Montevideo, 11600, Uruguay.
authors.forename: Justo
authors.initials: J
authors.lastname: Alonso
mesh_terms: D000282:Administration, Intravaginal; D000286:Administration, Sublingual; D000328:Adult; D001034:Apgar Score; D020070:Cervical Ripening / Q000187:drug effects*; D036861:Delivery, Obstetric; D005260:Female; D005865:Gestational Age; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D016037:Single-Blind Method
chemical_list: D010120:Oxytocics; D016595:Misoprostol
keywords: Cervical ripening; Misoprostol; Sublingual