title: Association Between Dehydration and Fever During the First Week of Life.
abstract: BACKGROUND
  Trying to differentiate serious bacterial infection (SBI) from a self-limiting illness in febrile infants seen in the pediatric emergency department (PED) is a significant challenge. The aim of the study was to determine the prevalence of dehydration and its relationship to SBI in febrile full-term newborns under 1 week of age seen in a PED.
  
  
  METHODS
  A retrospective observational study was carried out on all children younger than 8 days of age with fever who presented to a single, tertiary care, PED from January 2009 to April 2014. Dehydration was defined as plasma sodium >150 mmol/L or >10% loss of birth weight. SBI was defined by the presence of a positive culture in the blood, urine, cerebrospinal fluid; osteoarticular infection; bacterial enteritis; or pneumonia. The primary analysis was the proportion of children with dehydration. A secondary analysis compared proportion of infection according to hydration status.
  
  
  RESULTS
  Of the 895 children under 8 days of age who visited the PED, 69 consulted for fever. Seven patients were excluded because they were transferred from another hospital. Sixty-two eligible patients were included in the final analysis. Of these, 17 (27%) were dehydrated according to our definition. Only 2 patients had an SBI while 2 others had a final diagnosis of viral myocarditis and encephalitis, respectively. None of the 4 children with serious infection fulfilled our definition of dehydration, and all had a plasma sodium level lower than 145 mmol/L.
  
  
  CONCLUSIONS
  Dehydration is frequently associated with fever in infants younger than 8 days of age seen in a PED. Early identification of dehydration may be useful in limiting the aggressive intervention in some of these infants.
authors.affiliation: 1 CHU Sainte-Justine, Montreal, Quebec, Canada.|2 Montreal University, Montreal, Quebec, Canada.
authors.forename: Ariane
authors.initials: A
authors.lastname: Boutin
authors.affiliation: 1 CHU Sainte-Justine, Montreal, Quebec, Canada.|2 Montreal University, Montreal, Quebec, Canada.
authors.forename: Ana
authors.initials: A
authors.lastname: Carceller
authors.affiliation: 1 CHU Sainte-Justine, Montreal, Quebec, Canada.|2 Montreal University, Montreal, Quebec, Canada.
authors.forename: Marie Pier
authors.initials: MP
authors.lastname: Desjardins
authors.affiliation: 1 CHU Sainte-Justine, Montreal, Quebec, Canada.|2 Montreal University, Montreal, Quebec, Canada.
authors.forename: Marisol
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: 1 CHU Sainte-Justine, Montreal, Quebec, Canada.|2 Montreal University, Montreal, Quebec, Canada.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Gravel
mesh_terms: D001424:Bacterial Infections / Q000150:complications* / Q000175:diagnosis*; D015331:Cohort Studies; D003681:Dehydration / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004636:Emergency Service, Hospital; D005260:Female; D005334:Fever / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
keywords: dehydration; fever; neonates; serious bacterial infection