title: Crohn's disease diagnosis, treatment approach, and management paradigm: what the radiologist needs to know.
abstract: Crohn's disease is one of the major subtypes of idiopathic inflammatory bowel disease and is characterized by chronic transmural intestinal inflammation of the gastrointestinal tract anywhere from mouth to the anus, with a predilection for the small bowel. Cross-sectional imaging with computed tomography and magnetic resonance enterography plays a key role in confirming diagnosis, identifying and managing complications, assessing disease severity, and identifying response to medical therapy. This review will focus on the role of radiologists in the diagnosis and assessment of Crohn's disease. Additionally, a review of current medical therapy approaches, available medications, and side effects will be discussed. The review will also highlight key complications of medical therapy and associated diseases that should be evaluated by the radiologist with cross-sectional imaging.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Parakkal
authors.initials: P
authors.lastname: Deepak
authors.affiliation: Department of Gastroenterology, Inflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Sang Hyoung
authors.initials: SH
authors.lastname: Park
authors.affiliation: Division of Abdominal Imaging, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN, 55905, USA.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Ehman
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Hansel
authors.affiliation: Division of Abdominal Imaging, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN, 55905, USA.
authors.forename: Jeff L
authors.initials: JL
authors.lastname: Fidler
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Bruining
authors.affiliation: Division of Abdominal Imaging, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN, 55905, USA. fletcher.joel@mayo.edu.
authors.forename: Joel G
authors.initials: JG
authors.lastname: Fletcher
mesh_terms: D003287:Contrast Media; D003424:Crohn Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: Computed; Crohn’s disease management; Magnetic resonance imaging; Tomography; Tumor necrosis factor-alpha/antagonists and inhibitors; X-ray