title: Role ofHelicobacter pyloriEradication Therapy on Platelet Recovery in Chronic Immune Thrombocytopenic Purpura.
abstract: Background. Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys native platelets. In this condition an autoantibody is generated against a platelet antigen. ITP affects women more often than men and is more common in children than adults.Objective. To assess the effect ofHelicobacter pylorieradication therapy (HPET) on platelet count inHelicobacter pyloriassociated chronic immune thrombocytopenic purpura (chronic ITP) in adult.Materials and Methods. It is an interventional prospective study conducted at Liaquat University of Medical and Health Sciences, Jamshoro, from 2014 to 2015. A set of 85 patients diagnosed with chronic ITP were included in the study via convenient sampling. Patients with platelets count < 100 × 109/L for >3 months were selected. They were posed to first-line investigations which comprised complete blood count (CBC) and peripheral blood smear examination followed by second-line tests including bone marrow examination andHelicobacter pyloristool specific antigen (HpSA-EIA). StandardH. pylorieradication therapy was offered and the patients were assessed at regular intervals for 6 months.Results.Of the 85 study patients, 32 (37.6%) were male and 53 (62.3%) were female. Mean ages ofH. pyloripositive and negative subjects were 43.89 ± 7.06 and 44.75 ± 7.91 years, respectively. Bone marrow examination confirmed the diagnosis and excluded other related BM disorders.H. pyloristool antigen (HpSA) was detected in 34 (40%) patients and hence regarded asH. pyloripositive; the rest were negative. Treatment with eradication therapy significantly improved the mean platelet counts from 48.56 ± 21.7 × 109/l to 94.2 ± 26.8 × 109/l.Conclusion.We concluded that theanti-H. pylorieradication therapy improves blood platelet counts in chronic immune thrombocytopenia.
authors.affiliation: Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
authors.forename: Khan
authors.initials: K
authors.lastname: Sheema
authors.affiliation: Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
authors.forename: Ujjan
authors.identifier: 0000-0003-4032-5929
authors.initials: U
authors.lastname: Ikramdin
authors.affiliation: National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan.
authors.forename: Naz
authors.initials: N
authors.lastname: Arshi
authors.affiliation: Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
authors.forename: Naz
authors.initials: N
authors.lastname: Farah
authors.affiliation: Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
authors.forename: Sheikh
authors.initials: S
authors.lastname: Imran