title: Edible solid lipid nanoparticles (SLN) as carrier system for antioxidants of different lipophilicity.
abstract: Ferulic acid (FA) and tocopherol (Toc) loaded solid lipid nanoparticles (SLN) were prepared by a hot homogenisation method. The particle size distribution, zeta potential and melting behaviour of the SLN as well as the stability, encapsulation efficiency and radical scavenging activity of FA and Toc in the SLN were analysed. The different formulations containing up to 2.8 mg g-1 of FA or Toc were stable during at least 15 weeks of storage at room temperature. Despite partial degradation and / or release of FA and Toc during storage, significant radical scavenging activity was maintained. DSC measurements and radical scavenging tests after different time periods revealed that the re-structuring of the lipid matrix was connected to the enhanced antioxidant activity of Toc but did not affect the activity of FA.
authors.affiliation: Institute for Food Technology and Bioprocess Engineering, Max Rubner-Institut, Karlsruhe, Germany.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Oehlke
authors.affiliation: Institute for Food Technology and Bioprocess Engineering, Max Rubner-Institut, Karlsruhe, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Behsnilian
authors.affiliation: Institute for Food Technology and Bioprocess Engineering, Max Rubner-Institut, Karlsruhe, Germany.
authors.forename: Esther
authors.initials: E
authors.lastname: Mayer-Miebach
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces, Division of oxidic and organic interfaces Hermann-von-Helmoltz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Weidler
authors.affiliation: Institute for Food Technology and Bioprocess Engineering, Max Rubner-Institut, Karlsruhe, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Greiner
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002152:Calorimetry, Differential Scanning; D003373:Coumaric Acids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004355:Drug Stability; D004356:Drug Storage; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D013696:Temperature; D024505:Tocopherols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D014961:X-Ray Diffraction
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D004337:Drug Carriers; D016166:Free Radical Scavengers; D008055:Lipids; C004999:ferulic acid; D024505:Tocopherols