title: Assessment of hypoxic stress in 44 women with breast cancer in the West Algeria.
abstract: OBJECTIVE
  The objective of this study was to evaluate the expression of hypoxia-inducible transcription factor 1α (HIF1α) protein profile among women with breast cancer in a population of western Algerian and to correlate the intensity of this expression with prognosis histological grade Scarff Bloom and Richardson (SBR) of the disease and the age of the patients.
  
  
  METHODS
  We used a kit provided by Life Science Inc (UScnk) for a sandwich enzyme immunoassay for the quantitative measurement of in vitro HIF1α in plasma in 44 patients and 44 controls in a population of western Algerian. Then we looked for the correlation between the intensity of the expression of HIF1α and prognosis histological grade SBR and the age of the patients studied.
  
  
  RESULTS
  The results indicate high levels of HIF1α at SBRIII grade with an average value of 12.26 ± 0.5 ng/ml. The average age of patients is around 50 ± 1year. In healthy subjects the mean concentration of 1.88 ± 0.1 ng/ml represents HIF1α with a mean age of 49 ± 1year.
  
  
  CONCLUSIONS
  Clinical monitoring of patients treated for breast cancer by assaying the HIF1α marker seems to be very important in the prognosis.
authors.affiliation: Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria.|Faculty of Nature and Life, University of Science and Technology, Mohamed Boudiaf Oran, Algeria.
authors.forename: Asmahane
authors.initials: A
authors.lastname: Medjdoub
authors.affiliation: Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria.|Faculty of Nature and Life, University of Science and Technology, Mohamed Boudiaf Oran, Algeria.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Tahari
authors.affiliation: Pasteur Institut of Oran, Street Gambetta Sylvain Parent Cave Gay, Oran, Algeria.
authors.forename: Leila
authors.initials: L
authors.lastname: Belhabri
authors.affiliation: Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria.
authors.forename: Tewfik
authors.initials: T
authors.lastname: Sahraoui
authors.affiliation: Biology Laboratory of Development and Differentiation, Faculty of Science of Nature and Life, University of Oran 1 Ahmed Ben Bella, Algeria.
authors.forename: Fatima Zohra
authors.initials: FZ
authors.lastname: El Kebir
mesh_terms: D000462:Algeria; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D051795:Hypoxia-Inducible Factor 1, alpha Subunit