title: Interconnections between mRNA degradation and RDR-dependent siRNA production in mRNA turnover in plants.
abstract: Accumulation of an mRNA species is determined by the balance between the synthesis and the degradation of the mRNA. Individual mRNA molecules are selectively and actively degraded through RNA degradation pathways, which include 5'-3' mRNA degradation pathway, 3'-5' mRNA degradation pathway, and RNA-dependent RNA polymerase-mediated mRNA degradation pathway. Recent studies have revealed that these RNA degradation pathways compete with each other in mRNA turnover in plants and that plants have a hidden layer of non-coding small-interfering RNA production from a set of mRNAs. In this review, we summarize the current information about plant mRNA degradation pathways in mRNA turnover and discuss the potential roles of a novel class of the endogenous siRNAs derived from plant mRNAs.
authors.affiliation: Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, 153-8902, Japan.|Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tsuzuki
authors.affiliation: Institute of Transformative Bio-Molecules, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Motomura
authors.affiliation: Center for Sustainable Resource Science, RIKEN, Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Kumakura
authors.affiliation: Department of Biotechnology, Graduate School of Life Sciences, Ritsumeikan University, Shiga, 525-8577, Japan. atakeda@fc.ritsumei.ac.jp.
authors.forename: Atsushi
authors.identifier: http://orcid.org/0000-0002-4710-7118
authors.initials: A
authors.lastname: Takeda
mesh_terms: D003593:Cytoplasm / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D018749:RNA, Plant; D034741:RNA, Small Interfering; D012324:RNA-Dependent RNA Polymerase
keywords: 3′-5′ mRNA degradation; 5′-3′ mRNA degradation; Coding transcript-derived siRNA; RNA exosome; RNA quality control-siRNA; RNA silencing; RNA-dependent RNA polymerase; Virus-activated siRNA; mRNA turnover