title: Potential of redox therapies in neurodegenerative disorders.
abstract: Recently significant advances have been made to understand the pathophysiological mechanisms of neurodegenerative disorders to provide real therapeutic benefits. There is evidence that persistent inflammation and oxidative stress are the crucial factors of ongoing cell damage in neurodegenerative complex etiology. The variety of reactive oxygen and nitrogen species are the cause of both axonal and neuronal destruction, which is pathological hallmark of neurodegeneration. Therefore, the reduction of oxidative stress is currently one of the main neuroprotective strategies. The World Health Organization (WHO) estimates that, by 2040, neurodegenerative diseases will be the main cause of death in industrialized countries ahead of the cancers. The redox therapeutic approch can target: degnerative component, inflammatory/autoimmune component and neurodegenerative component. Redox therapy should not be applied uniformly, and must be develop to target specific mechanisms. This review focus on the main antitoxidative therapies that are used in many countries as a supplements or even as a standart treatment. Aditionally, clinical synmptoms of most common neurodegenerative disordes and centralnervous system structures involved in oxidative/nitrosative stress are showed.
authors.affiliation: Department of Physical Medicine, Medical University of Lodz, Hallera Square, 1, Lodz, Poland, elzbieta.dorota. miller@umed.lodz.pl.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Miller
authors.affiliation: Department of Chemistry and Clinical Biochemistry, Medical University of Lodz.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Markiewicz
authors.affiliation: Department of Chemistry and Clinical Biochemistry, Medical University of Lodz, Hallera Square 1, Lodz, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kabzinski
authors.affiliation: Department of Pathology, Faculty of Health Sciences, Jan Kochanowski Memorial University of Kielce, Kielce, Poland, and Ophthalmology Clinic Boni Frates Lodziensis, Lodz, Poland.
authors.forename: Dominik
authors.initials: D
authors.lastname: Odrobina
authors.affiliation: Department of Chemistry and Clinical Biochemistry, Medical University of Lodz, Hallera Square 1, Lodz, Poland.
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Majsterek
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D019587:Dietary Supplements; D006801:Humans; D053858:Metabolic Networks and Pathways; D018977:Micronutrients / Q000627:therapeutic use*; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D018977:Micronutrients