title: Microbe Profile: Escherichia coli O157 : H7 - notorious relative of the microbiologist's workhorse.
abstract: of enterohaemorrhagic Escherichia coli O157 pathogenesis using basic symbols. The right-hand illustration shows enterohaemorrhagic E. coli interactions with an epithelial cell.Escherichia coli O157 : H7 is a zoonotic diarrhoeal pathogen of worldwide importance. It belongs to a subset of Shiga toxin-producing E. coli that can form attaching and effacing lesions on intestinal epithelia via the action of a type 3 secretion system that injects bacterial effectors into enterocytes. Infections in humans often arise from contaminated food or direct environmental exposure and can involve life-threatening Shiga toxin-dependent sequelae. In the three decades since E. coli O157 : H7 was first recognized intensive research has helped to unravel the basis of pathogenesis, but few effective options for prevention and treatment of infections exist.
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
authors.forename: David L
authors.initials: DL
authors.lastname: Gally
authors.affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Stevens
mesh_terms: D004927:Escherichia coli Infections / Q000382:microbiology / Q000473:pathology*; D019453:Escherichia coli O157 / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D016680:Genome, Bacterial / Q000235:genetics; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology*; D022621:Shiga Toxin / Q000378:metabolism*; D000069296:Type III Secretion Systems / Q000378:metabolism
chemical_list: D000069296:Type III Secretion Systems; D022621:Shiga Toxin