title: Correlation between NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and increased risk of esophageal cancer: evidence from a meta-analysis.
abstract: NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphisms have been reported to influence the risk for esophageal cancer (EC) in many studies. However, the results remain controversial and ambiguous. We performed a meta-analysis, which included 13 independent studies with a total of 2357 subjects, to examine the association between NQO1 C609T polymorphism and EC. The association was assessed by five different gene models. The overall analysis suggested that the variant allele and genotypes were significantly related to increased risk of EC (odds ratio [OR] TversusC = 1.15, 95% confidence interval [CI] 0.95-1.40, probability of rejection [POR] = 0.014; OR TTversusCC = 1.32, 95% CI 1.01-1.73, POR = 0.045; OR TCversusCC = 1.32, 95% CI 0.98-1.21, POR = 0.128; OR TT + TCversusCC = 1.10, 95% CI 1.00-1.20, POR = 0.05; OR TTversusCC + TC = 1.26, 95% CI 0.95-1.57, POR = 0.103). Sensitivity analysis confirmed the reliability of these findings. Our study shows that individuals carrying the NQO1 C609T variant allele and genotypes are more susceptible to EC.
authors.affiliation: Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou, People's Republic of China.
authors.forename: Jingfang
authors.initials: J
authors.lastname: Diao
authors.affiliation: Department of Internal Medicine, Hospital of South China Normal University, Guangzhou, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bao
authors.affiliation: Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou, People's Republic of China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou, People's Republic of China.
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Mo
authors.affiliation: Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou 510120, People's Republic of China.
authors.forename: Junming
authors.initials: J
authors.lastname: He
keywords: NAD(P)H: quinone oxidoreductase 1; esophageal cancer; meta-analysis; single nucleotide polymorphisms