title: Fatty acid and mineral receptors as drug targets for gastrointestinal disorders.
abstract: Nutrient-sensing receptors, including fatty acid receptors (FFA1-FFA4), Ca2+-sensing receptors and Zn2+-sensing receptors, are involved in several biological processes. These receptors are abundantly expressed in the GI tract, where they have been shown to play crucial roles in regulating GI function. This review provides an overview of the GI functions of fatty acid and mineral receptors, including the regulation of gastric and enteroendocrine functions, GI motility, ion transport and cell growth. Recently, several lines of evidence have implicated these receptors as promising therapeutic targets for the treatment of GI disorders, for example, inflammatory bowel disease, colorectal cancer, metabolic syndrome and diarrheal diseases. A future perspective on drug discovery research targeting these receptors is discussed.
authors.affiliation: Graduate Program in Translational Medicine, Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
authors.forename: Pawin
authors.initials: P
authors.lastname: Pongkorpsakol
authors.affiliation: Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
authors.forename: Aekkacha
authors.initials: A
authors.lastname: Moonwiriyakit
authors.affiliation: Graduate Program in Translational Medicine, Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.|Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.|Excellent Center for Drug Discovery, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
authors.forename: Chatchai
authors.initials: C
authors.lastname: Muanprasat
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism; D055808:Drug Discovery; D005227:Fatty Acids / Q000378:metabolism*; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D043562:Receptors, G-Protein-Coupled; D015032:Zinc; D002118:Calcium
keywords: calcium-sensing receptor; fatty acid receptors; zinc-sensing receptor