title: Comparison of laser and ozone treatments on oral mucositis in an experimental model.
abstract: Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-β), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-β, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey.
authors.forename: Suzan
authors.initials: S
authors.lastname: Bayer
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey. dt_oguz@yahoo.com.
authors.forename: Hakki Oguz
authors.initials: HO
authors.lastname: Kazancioglu
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey.
authors.forename: Ahmet Hüseyin
authors.initials: AH
authors.lastname: Acar
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey.
authors.forename: Nihat
authors.initials: N
authors.lastname: Demirtas
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Nur Ozten
authors.initials: NO
authors.lastname: Kandas
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007834:Lasers; D028022:Low-Level Light Therapy; D008297:Male; D010126:Ozone / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D013280:Stomatitis / Q000188:drug therapy* / Q000532:radiotherapy*; D014945:Wound Healing / Q000528:radiation effects
chemical_list: D010126:Ozone
keywords: Dentistry; Healing; Histology; Laser; Mucositis; Ozone; Treatment