title: Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings.
abstract: Here we present a route for non-covalent functionalization of carboxylated multi-walled carbon nanotubes and graphene oxide with novel two-dimensional peptide assemblies. We show that self-assembled amino-terminated biantennary and tetraantennary oligoglycine peptides (referred to as tectomers) effectively coat carboxylated multi-walled carbon nanotubes and also strongly interact with graphene oxide due to electrostatic interactions and hydrogen bonding as the driving force, respectively. The resulting hybrids can be made into free-standing conducting composites or applied in the form of thin, pH-switchable bioadhesive coatings onto graphene oxide fibers. Monitoring of cell viability of pancreatic cell lines, seeded on those CNT hybrids, show that they can be used as two- and three-dimensional scaffolds to tissue engineer tumour models for studying ex vivo the tumour development and response to treatment. This highly versatile method in producing pH-responsive hybrids and coatings offers an attractive platform for a variety of biomedical applications and for the development of functional materials such as smart textiles, sensors and bioelectronic devices.
authors.affiliation: Departamento de Química Física, Universidad de Zaragoza, 50009 Zaragoza, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Garriga
authors.forename: Izabela
authors.initials: I
authors.lastname: Jurewicz
authors.forename: Shayan
authors.initials: S
authors.lastname: Seyedin
authors.forename: Niki
authors.initials: N
authors.lastname: Bardi
authors.forename: Stella
authors.initials: S
authors.lastname: Totti
authors.forename: Brigitta
authors.initials: B
authors.lastname: Matta-Domjan
authors.forename: Eirini G
authors.initials: EG
authors.lastname: Velliou
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Alkhorayef
authors.forename: Vicente L
authors.initials: VL
authors.lastname: Cebolla
authors.forename: Joselito M
authors.initials: JM
authors.lastname: Razal
authors.forename: Alan B
authors.initials: AB
authors.lastname: Dalton
authors.forename: Edgar
authors.initials: E
authors.lastname: Muñoz