title: Singling Out Chromosome Gains in Tumor Evolution.
abstract: In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability.
authors.affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Naylor
authors.affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: vandeursen.jan@mayo.edu.
authors.forename: Jan M
authors.initials: JM
authors.lastname: van Deursen
mesh_terms: D000782:Aneuploidy; D002869:Chromosome Aberrations; D002875:Chromosomes; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000235:genetics*