title: In vivofield recordings effectively monitor the mouse cortex and hippocampus under isoflurane anesthesia.
abstract: Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hippocampus and cortex using anin vivofield recording approach. Our results showed that 1.3%, 0.8%, and 0.4% isoflurane exerted an inhibitory influence on the mouse hippocampus and cortex. Further, high frequency bands in the cortex and hippocampus showed greater suppression with increasing isoflurane concentration. Our findings suggest thatin vivofield recordings can monitor the effect of isoflurane anesthesia on the mouse cortex and hippocampus.
authors.affiliation: Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yi-Qing
authors.initials: YQ
authors.lastname: Yin
authors.affiliation: Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Gao
authors.affiliation: Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Zi-Fang
authors.initials: ZF
authors.lastname: Zhao
authors.affiliation: Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Cheng-Hui
authors.identifier: 0000-0002-8531-2489
authors.initials: CH
authors.lastname: Li
keywords: cell membrane; electrophysiology; inhalational anesthesia; isoflurane; nerve regeneration; neurons; patch clamp; synaptic response