title: Extracellular regulation of BMP signaling: welcome to the matrix.
abstract: Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.
authors.affiliation: Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University Heidelberg, 68167 Mannheim, Germany georg.sedlmeier@medma.uni-heidelberg.de jonathan.sleeman@medma.uni-heidelberg.de.
authors.forename: Georg
authors.initials: G
authors.lastname: Sedlmeier
authors.affiliation: Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University Heidelberg, 68167 Mannheim, Germany georg.sedlmeier@medma.uni-heidelberg.de jonathan.sleeman@medma.uni-heidelberg.de.|Institute for Toxicology and Genetics, Karlsruhe Institute of Technology Campus Nord, 76021 Karlsruhe, Germany.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Sleeman
mesh_terms: D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D019485:Bone Morphogenetic Proteins; D016326:Extracellular Matrix Proteins; D052004:Bone Morphogenetic Protein Receptors
keywords: ECM; bone morphogenetic protein; collagen; hyaluronic acid; mechanosignaling; proteoglycan