title: Long non-coding RNAs act as regulators of cell autophagy in diseases (Review).
abstract: Identification of long non-coding RNAs (lncRNAs) has provided a substantial increase in our understanding of the non-coding transcriptome. Studies have revealed a crucial function of lncRNAs in the modulation of cell autophagy in vitro and in vivo, further contributing to the hallmarks of disease phenotypes. These findings have profoundly altered our understanding of disease pathobiology, and may lead to the emergence of new biological concepts underlying autophagy-associated diseases, such as the carcinomas. Studies on the molecular mechanism of the lncRNA-autophagy axis may offer additional avenues for therapeutic intervention and biomarker assessment. In this review, we discuss recent findings on the multiple molecular roles of regulatory lncRNAs in the signaling pathways of cell autophagy. The emerging knowledge in this rapidly advancing field will offer novel insights into human diseases, especially cancers.
authors.affiliation: Department of Pathology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Yuanliang
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Gong
mesh_terms: D000818:Animals; D001343:Autophagy; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding