title: Buccal films as a dressing for the treatment of aphthous lesions.
abstract: BACKGROUND
  Buccal flexible films in the form of solid, thin, mucoadhesive patches can be used as dressings separating aphthous lesions from the environment of the oral cavity, which can in turn shorten the treatment period and reduce the pain perception.
  
  
  METHODS
  The clinical study was performed on 36 volunteers suffering from aphthous lesions. The first group was treated using standard means-by application of an oral gel containing cholin salicylate (Mundisal) on the aphthous lesion. The second group was treated with the same preparation; however, the lesion was covered with a mucoadhesive film following the application of the gel. The criteria for statistical evaluation were the size of lesions in relation to the length of the treatment and the subjective perception of the treatment results.
  
  
  CONCLUSIONS
  The application of buccal films covering aphthous lesions during the treatment significantly increased the rate of healing when compared with the standard methods of treatment. While the pain improvement was statistically significant as soon as Day 3 in the experimental group, it was only apparent on Day 5 in the control group, and the number of successfully treated patients (pain perception improving to visual analogue scale 2 or less) was at all time points higher in the experimental group than in the control group. The results imply that the use of buccal films for treatment of aphthous lesions is very promising and can lead to a significant reduction in the duration of patients' discomfort.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Masaryk University, University Hospital Brno, Brno, Czech Republic.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Daněk
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
authors.forename: Jan
authors.identifier: http://orcid.org/0000-0002-2551-1099
authors.initials: J
authors.lastname: Gajdziok
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Doležel
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Landová
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Vetchý
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Ostrava, Ostrava, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Štembírek
mesh_terms: D000269:Adhesives / Q000627:therapeutic use; D000278:Administration, Buccal; D000293:Adolescent; D000328:Adult; D000368:Aged; D001458:Bandages; D006801:Humans; D008297:Male; D008875:Middle Aged; D013281:Stomatitis, Aphthous / Q000628:therapy*; D055815:Young Adult
chemical_list: D000269:Adhesives
keywords: aphthous lesions; mucoadhesive buccal films; oral mucosa; pain reduction; residence time