title: Impact of polymorphisms in angiogenesis-related genes on clinical outcomes of radiotherapy in patients with nasopharyngeal carcinoma.
abstract: The purpose of this paper is to assess the relationship between gene polymorphism in angiogenesis-related genes and radiation responses in nasopharyngeal carcinoma (NPC) patients. The genotypes of 180 NPC patients were analyzed by Sequenom MassARRAY. The response evaluation criteria in solid tumours were used for assessing efficacies, and the criteria of the Radiation Therapy Oncology Group or European Organization for Research & Treatment of Cancer were utilized for evaluating acute toxic reactions in response to radiation. Statistical methods included chi-square test, uni- and multivariate logistic regression analyses. Genotypic carriers of rs1800541 GT were at an elevated risk of developing grade 3+ oral mucositis, and a genetic variant of rs5333 was a predictor for a lower occurring risk of grade 2+ radiation-induced xerostomia. EDN1 rs1800541, rs2071942 and rs5370 variants were associated with a significantly higher risk of severe myelosuppression. SNPs in such angiogenesis-related genes as EDN1 rs1800541, rs2071942 & rs5370 and EDNRA rs5333 may serve as useful biomarkers for predicting the outcomes of NPC patients.
authors.affiliation: Centre of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Wan-Le
authors.initials: WL
authors.lastname: Ma
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Centre of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Huang
authors.affiliation: Centre of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Chan
authors.initials: C
authors.lastname: Zou
authors.affiliation: Centre of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Jiangxi Province Tumour Hospital, Nanchang, Jiangxi, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oncology, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou, Guangxi, China.
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Chen
authors.affiliation: Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan, China.
authors.forename: Xiang-Guang
authors.initials: XG
authors.lastname: Meng
authors.affiliation: Department of Haematology, Affiliated Cancer Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Jing-Ke
authors.initials: JK
authors.lastname: Yang
authors.affiliation: Zhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang, Henan, China.
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.affiliation: Centre of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Yang
authors.affiliation: Centre of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Cheng-Xian
authors.initials: CX
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics* / Q000532:radiotherapy*; D019332:Endothelin-1 / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000532:radiotherapy*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics* / Q000528:radiation effects; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019332:Endothelin-1
keywords: angiogenesis-related gene; nasopharyngeal carcinoma; nucleotide polymorphism; radiation therapy; single treatment efficacy; tissue toxicity