title: Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus).
abstract: A 17-year-old female wolf (Canis lupus lupus) had a right lung mass that was adhered to the thoracic cavity. Histopathological examination revealed that the mass consisted of sheets, cord or ribbon-like structures of monotonous, small, cuboidal cells with round, oval or short-spindle nuclei and scant clear cytoplasm, demarcated by a fine fibrovascular stroma. Focal necrosis, congestion and thrombi were observed. Immunohistochemically, the tumor cells diffusely expressed cytokeratin AE1/AE3, and some expressed chromogranin A, neural cell adhesion molecule (CD56) and thyroid transcription factor-1. The number of proliferating cell nuclear antigen-positive tumor cells was low. A diagnosis of pulmonary neuroendocrine tumor was based on the resemblance to carcinoids.
authors.affiliation: Laboratory of Veterinary Pathology, Veterinary Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Shiraki
authors.forename: Toshinori
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masahi
authors.initials: M
authors.lastname: Kawashima
authors.forename: Hirotada
authors.initials: H
authors.lastname: Murayama
authors.forename: Rei
authors.initials: R
authors.lastname: Nagahara
authors.forename: Nanao
authors.initials: N
authors.lastname: Ito
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibutani
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology / Q000662:veterinary*; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000662:veterinary*; D019596:Wolves