title: Place cells are more strongly tied to landmarks in deep than in superficial CA1.
abstract: Environmental cues affect place cells responses, but whether this information is integrated versus segregated in distinct hippocampal cell populations is unclear. Here, we show that, in mice running on a treadmill enriched with visual-tactile landmarks, place cells are more strongly controlled by landmark-associated sensory inputs in deeper regions of CA1 pyramidal layer (CA1d). Many cells in CA1d display several firing fields correlated with landmarks, mapping positions slightly before or within the landmarks. Supporting direct involvement of sensory inputs, their firing fields show instantaneous responses to landmark manipulations, persist through change of context, and encode landmark identity and saliency. In contrast, cells located superficially in the pyramidal layer have single firing fields, are context specific and respond with slow dynamics to landmark manipulations. These findings suggest parallel and anatomically segregated circuits within CA1 pyramidal layer, with variable ties to landmarks, allowing flexible representation of spatial and non-spatial information.
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.|Department of Psychology, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Tristan
authors.identifier: 0000-0001-8957-7786
authors.initials: T
authors.lastname: Geiller
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.|Department of Neuroscience, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fattahi
authors.affiliation: Department of Psychology, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: June-Seek
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.|Department of Neuroscience, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Royer
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology*; D056654:CA3 Region, Hippocampal / Q000166:cytology*; D003463:Cues; D008297:Male; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology; D009949:Orientation / Q000502:physiology; D000071037:Place Cells / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D013028:Space Perception / Q000502:physiology