title: Correlation between Infective Factors and Antibiotic Resistance inEnterococciClinical Isolates in West of Iran.
abstract: The present study was done to scrutinize the possible relation between infective genes and antimicrobial resistance inEnterococcus faecalisandEnterococcus faecium. Considering the fact that the presence of recognized infective determinants among clinical isolates may promote the emergence of infections and persistence ofEnterococciin hospital settings, which can lead to an increase in antimicrobial resistance. 175E. faecalisand 67E. faeciumisolated from clinical specimens were used. The isolates were identified, and then antibiotic susceptibility testing was performed. The MIC of vancomycin and teicoplanin were determined by broth microdilution method. The presence of infective genesesp,hylandasa1was scrutinized using PCR. Of the 280 enterococcal isolates, 175 (62.5%) isolates were identified asE. faecalis, 67 (24%) asE. faeciumand 38 (13.5%) asEnterococcusspp. The results of the antibiotic susceptibility testing showed resistance rates of 5% and 73% to vancomycin and teicoplanin inE. faecalisandE. faeciumisolates, respectively. The statistical analysis showed that theespinfective gene has significant associations with ciprofloxacin, erythromycin and tetracycline inE. faeciumand with chloramphenicol inE. faecalisstrains; thehylwith teicoplanin and vancomycin inE. faeciumstrains; and alsoasa1with vancomycin inE. faeciumand with ampicillin and chloramphenicol inE. faecalisstrains. Regarding the relationships between virulence genes and antibiotic resistance in strains ofE. faecalisandE. faecium, detection of infective factors associated with invasive diseases has become a major issue of concern.
authors.affiliation: Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran.; Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Arabestani
authors.affiliation: Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran.
authors.forename: Mona
authors.initials: M
authors.lastname: Nasaj
authors.affiliation: Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran.
authors.forename: Seyed Masoud
authors.initials: SM
authors.lastname: Mousavi
keywords: Anti-Bacterial Agents; Enterococcus; Virulence