title: Value of Shear Wave Elastography in the Diagnosis of Gouty and Non-Gouty Arthritis.
abstract: Our aim was to analyze the diagnostic performance of shear wave elastography (SWE) in the diagnosis of gouty arthritis (GA) and non-gouty arthritis (non-GA). Thirty-nine patients in the GA group and 55 patients in the non-GA group were included in the study. Based on the echo intensity of the joint lesions, the GA group was subdivided into hypo-echoic GA, slightly hyper-echoic GA and hyper-echoic GA subgroups. Quantitative SWE features were evaluated and receiver operating characteristic analysis was performed. On the basis of the study, the elastic modulus (Emax), mean elastic modulus (Emean), minimum elastic modulus (Emin) and elastic modulus standard deviation (ESD) were significantly higher in the GA group than in the non-GA group and were highest in the hyper-echoic GA subgroup (p < 0.01 for all). Emin, Emeanand Emaxwere significantly higher in the hyper-echoic GA subgroup than in the hypo-echoic GA subgroup and non-GA group (p < 0.001 for all), and ESDwas significantly higher in the hyper-echoic GA subgroup than in the non-GA group (p = 0.001). Emin, Emean, Emaxand ESDwere higher in the hypo-echoic GA subgroup than in the non-GA group, and the differences were significant (p < 0.001 for all). Based on the hypo-echoic GA subgroup and non-GA group, areas under the receiver operating characteristic curves for the prediction of GA were 0.749 for Emin, 0.877 for Emean, 0.896 for Emaxand 0.886 for ESD, with optimal cutoff values of 29.40 kPa for Emin, 45.35 kPa for Emean, 67.54 kPa for Emaxand 7.85 kPa for ESD. Our results indicate that SWE can differentially diagnose GA and non-GA, especially when the ultrasound manifestations are not typical.
authors.affiliation: Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yuanjiao
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Clinical Ultrasound Imaging Drug Research Lab, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.affiliation: Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yujia
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Xiang
authors.affiliation: Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Liyun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address: Wsqiuli@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000000981:diagnostic imaging*; D015210:Arthritis, Gouty / Q000000981:diagnostic imaging; D002648:Child; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007596:Joints / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D055815:Young Adult
keywords: Gouty arthritis; Non-gouty arthritis; Shear wave elastography; Stiffness; Ultrasound