title: Synthesis and Evaluation of a Triblock Copolymer/ZnO Nanoparticles from Poly(ε-caprolactone) and Poly(Acrylic Acid) as a Potential Drug Delivery Carrier.
abstract: Through the present paper, a triblock copolymer containing pH-responsive (polyacrylic acid-b-polycaprolactone -b-polyacrylic acid) (PAA-b-PCL-b-PAA) was synthesized by using the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and the reversible addition fragmentation chain transfer (RAFT) polymerization of the acrylic acid methods, as the drug carrier. Blends of the nanocrystalline zinc oxide nanoparticles (n-ZnO) and triblock copolymer treated from the solution have been used to make the hybrid polymer-metal oxide for the preparation of the drug loaded nanocomposite. The drug-release behavior of the nanocomposite was studied by using the Doxorubicin as a model drug. In addition to the self-assembly and pH-responsive behavior of the triblock copolymers/ZnO was studied in solution by the Fluorescence Spectroscopy, Scanning Electron Microscopy(SEM), Transmission Electron Microscopy (TEM), DLS, HNMR and FT-IR spectroscopy.
authors.affiliation: Lab. of Nano, Faculty of Chemistry, Payame Noor University, Iran.
authors.forename: Lida
authors.initials: L
authors.lastname: Ahmadkhani
authors.affiliation: Lab. of Nano, Faculty of Chemistry, Payame Noor University, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Baghban
authors.affiliation: Dipartimento di Chimica, Materiali eingeneria Chimica "Giulio Natta" Politecnico di Milano-Italia.
authors.forename: Shahram
authors.initials: S
authors.lastname: Mohammadpoor
authors.affiliation: Faculty of Biology, Department of Biophysics and Molecular Biology, Baku State University, Baku, Azerbaijan Republic.
authors.forename: Rovshan
authors.initials: R
authors.lastname: Khalilov
authors.affiliation: Stem Cell Research Center,Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.affiliation: Joint Ukrainian-Azerbaijan International Research and Education Center Of Nanobiotechnology and Functional Nanosystems, Drohobych Ukraine & Baku, Azerbaijan.
authors.forename: Taras
authors.initials: T
authors.lastname: Kavetskyy
authors.affiliation: Faculty of Biology, Department of Biophysics and Molecular Biology, Baku State University, Baku, Azerbaijan Republic.
authors.forename: Siamak
authors.initials: S
authors.lastname: Saghfi
authors.affiliation: Joint Ukrainian-Azerbaijan International Research and Education Center Of Nanobiotechnology and Functional Nanosystems, Drohobych Ukraine & Baku, Azerbaijan.
authors.forename: Aygun N
authors.initials: AN
authors.lastname: Nasibova
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000138:chemical synthesis*; D065546:Drug Liberation; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D008854:Microscopy, Electron; D008970:Molecular Weight; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013053:Spectrophotometry; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; C006903:carbopol 940; D004317:Doxorubicin; D015034:Zinc Oxide