title: [The alpha-herpesviridae in dermatology : Herpes simplex virus types I and II. German version].
abstract: This review on herpes simplex virus type I and type II (HSV-I, HSV-II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV-I infection; HSV-related folliculitis; verrucous HSV-I and HSV-II lesions; the role of recurrent HSV-I infection in burning mouth syndrome; HSV-I and HSV-II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV-I or HSV-II are discussed. The usual antiviral treatment regimens for primary and recurrent orolabial and genital herpes are compared to short-term and one-day treatment options. New anti-HSV-I and anti-HSV-II agents include amenavir, pritelivir, brincidofovir, valomaciclovir, and FV-100. Therapeutic or preventive vaccination against HSV-I and HSV-II infections still remains a highly desirable treatment aim, which, unfortunately, has no clinically relevant applications to date.
authors.affiliation: Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgien.
authors.forename: L
authors.initials: L
authors.lastname: El Hayderi
authors.affiliation: Hautklinik, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule Aachen, Pauwelsstraße 30, Aachen, 52074, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Rübben
authors.affiliation: Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgien. af.nikkels@chu.ulg.ac.be.
authors.forename: A F
authors.initials: AF
authors.lastname: Nikkels
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D019317:Evidence-Based Medicine; D006558:Herpes Genitalis / Q000175:diagnosis* / Q000628:therapy*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D016896:Treatment Outcome; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines
keywords: Genital herpes; Orolabial herpes; Skin; Treatment; Vaccination