title: Temporal acoustic measures distinguish primary progressive apraxia of speech from primary progressive aphasia.
abstract: The purpose of this study was to determine if acoustic measures of duration and syllable rate during word and sentence repetition, and a measure of within-word lexical stress, distinguish speakers with primary progressive apraxia of speech (PPAOS) from nonapraxic speakers with the agrammatic or logopenic variants of primary progressive aphasia (PPA), and control speakers. Results revealed that the PPAOS group had longer durations and reduced rate of syllable production for most words and sentences, and the measure of lexical stress. Sensitivity and specificity indices for the PPAOS versus the other groups were highest for longer multisyllabic words and sentences. For the PPAOS group, correlations between acoustic measures and perceptual ratings of AOS were moderately high to high. Several temporal measures used in this study may aid differential diagnosis and help quantify features of PPAOS that are distinct from those associated with PPA in which AOS is not present.
authors.affiliation: Department of Neurology (Speech Pathology), Mayo Clinic, Rochester, MN, USA. Electronic address: jduffy@mayo.edu.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Duffy
authors.affiliation: Department of Communication Sciences and Disorders, University of North Carolina, Greensboro, NC, USA.
authors.forename: Holly
authors.initials: H
authors.lastname: Hanley
authors.affiliation: Department of Neurology (Speech Pathology), Mayo Clinic, Rochester, MN, USA.
authors.forename: Rene
authors.initials: R
authors.lastname: Utianski
authors.affiliation: Department of Neurology (Speech Pathology), Mayo Clinic, Rochester, MN, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Clark
authors.affiliation: Department of Neurology (Speech Pathology), Mayo Clinic, Rochester, MN, USA.
authors.forename: Edythe
authors.initials: E
authors.lastname: Strand
authors.affiliation: Department of Neurology (Behavioral Neurology and Movement Disorders), Mayo Clinic, Rochester, MN, USA.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
authors.affiliation: Department of Radiology (Neuroradiology), Mayo Clinic, Rochester, MN, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Whitwell
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000175:diagnosis*; D001072:Apraxias / Q000175:diagnosis*; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057178:Primary Progressive Nonfluent Aphasia / Q000175:diagnosis*; D015203:Reproducibility of Results; D013061:Speech Acoustics
keywords: Acoustic analysis; Primary progressive aphasia; Primary progressive apraxia of speech