title: Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome.
abstract: OBJECTIVE
  To investigate possible relationships among oral mucosal epithelial MUC1 expression, salivary female gonadal hormones and stress markers, and clinical characteristics in patients with burning mouth syndrome (BMS).
  
  
  METHODS
  Thirty post-menopausal female patients with BMS (60.0±5.0 years) were included. Clinical and psychological evaluations were performed and the expression level of oral mucosal epithelial MUC1 was analyzed. The levels of cortisol, dehydroepiandrosterone (DHEA), 17β-estradiol, progesterone, chromogranin A, and blood contamination were determined from unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) samples.
  
  
  RESULTS
  Salivary progesterone level had significant positive correlations with oral mucosal epithelial MUC1 expression level and with salivary cortisol and DHEA levels. The salivary level of 17β-estradiol showed significant positive correlations with period of symptom duration, severity of effects of oral complaints on daily life, and results from psychological evaluations. Cortisol level in UWS and cortisol/DHEA ratio in UWS and SWS had negative correlations with severity of oral burning sensation significantly. The severity of taste disturbance had positive correlations with results from psychometry significantly.
  
  
  CONCLUSIONS
  Dysregulated psychoendocrinological interactions might affect oral mucosal MUC1 expression and severity of oral burning sensation in post-menopausal BMS patients.
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul 03080, South Korea.
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul 03080, South Korea.
authors.forename: Yoon-Young
authors.initials: YY
authors.lastname: Kim
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul 03080, South Korea.
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Chang
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul 03080, South Korea; Institute on Aging Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, South Korea. Electronic address: hkho@snu.ac.kr.
authors.forename: Hong-Seop
authors.initials: HS
authors.lastname: Kho
mesh_terms: D002054:Burning Mouth Syndrome / Q000378:metabolism* / Q000523:psychology; D003687:Dehydroepiandrosterone / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D010147:Pain Measurement; D017698:Postmenopause; D011374:Progesterone / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D012463:Saliva / Q000737:chemistry*
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D006854:Hydrocortisone
keywords: Burning mouth syndrome; Gonadal hormone; MUC1; Saliva; Stress