title: Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: A case series.
abstract: Synthetic cannabinoids are relatively new substances of abuse. Recently, abuse of synthetic cannabinoids has been increasingly reported in the lay press and medical literature. When new compounds are introduced, their use is initially not restricted by prohibition therefore their consumption cannot be verified by standard drug tests. The use of these compounds among adolescents and young adults is constantly growing, making it important for emergency services to be familiar with the signs and symptoms of intoxication present. Overdose and chronic use of these substances can cause adverse effects including altered mental status, tachycardia, and loss of consciousness. Here, we report five cases of acute intoxication by synthetic cannabinoids 5F-ADB and MMB-2201 with analytical confirmation.
authors.affiliation: Clinical Toxicology Unit, Clinical Analysis Department, Hospital Universitari Son Espases, Research Institute of Health Sciences (IdISPa), Palma de Mallorca, Spain. Electronic address: bernardino.barcelo@ssib.es.
authors.forename: Bernardino
authors.initials: B
authors.lastname: Barceló
authors.affiliation: National Centre on Addiction and Doping, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161, Rome, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Pichini
authors.affiliation: Division of Emergency, Department of Paediatrics, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: López-Corominas
authors.affiliation: Clinical Toxicology Unit, Clinical Analysis Department, Hospital Universitari Son Espases, Research Institute of Health Sciences (IdISPa), Palma de Mallorca, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gomila
authors.affiliation: Emergency Medicine Department, Clinical Toxicology Unit, Hospital Universitari Son Espases, Research Institute of Health Sciences (IdISPa), Palma de Mallorca, Spain.
authors.forename: Christopher
authors.initials: C
authors.lastname: Yates
authors.affiliation: Unit of Forensic Toxicology (UoFT), Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Italy.
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Busardò
authors.affiliation: National Centre on Addiction and Doping, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161, Rome, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Pellegrini
mesh_terms: D000293:Adolescent; D017109:Akathisia, Drug-Induced; D001007:Anxiety / Q000139:chemically induced; D002186:Cannabinoids / Q000009:adverse effects*; D003221:Confusion / Q000139:chemically induced; D015198:Designer Drugs / Q000009:adverse effects*; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D015878:Mydriasis / Q000139:chemically induced; D011605:Psychoses, Substance-Induced; D019966:Substance-Related Disorders / Q000150:complications*; D014839:Vomiting / Q000139:chemically induced; D055815:Young Adult
chemical_list: D002186:Cannabinoids; D015198:Designer Drugs; C000616976:5F-ADB cannabinoid
keywords: 5F-ADB; MMB-2201; Synthetic cannabinoids; Urine