title: Diet-induced obesity, gut microbiota and bone, including alveolar bone loss.
abstract: Obesity is a major risk factor for several pathologies, including jaw bone resorption. The underlying mechanisms involved in pathological conditions resulting from obesity include chronic systemic inflammation and the development of insulin resistance. Although numerous studies have indicated the importance of the role of gut microbiota in the pathogenesis of inflammation and insulin resistance in obesity, only a few studies have established a relationship between obesity, gut microbiota and status of the jaw bone. This review aims to summarize current findings relating to these issues, focusing on the role of obesity and gut microbiota on jaw bone health, including possible mechanisms which can explain this link.
authors.affiliation: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 5020, Thailand.
authors.forename: Sathima
authors.initials: S
authors.lastname: Eaimworawuthikul
authors.affiliation: Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
authors.forename: Parameth
authors.initials: P
authors.lastname: Thiennimitr
authors.affiliation: Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 5020, Thailand.
authors.forename: Nipon
authors.initials: N
authors.lastname: Chattipakorn
authors.affiliation: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 5020, Thailand. Electronic address: scchattipakorn@gmail.com.
authors.forename: Siriporn C
authors.initials: SC
authors.lastname: Chattipakorn
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology*; D059305:Diet, High-Fat / Q000009:adverse effects*; D002149:Energy Intake; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications* / Q000209:etiology / Q000382:microbiology*; D012307:Risk Factors
keywords: Gut microbiota; Insulin resistance; Jaw bone; Obesity