title: Comparative clinical and radiographic evaluation of mineralized cancellous bone allograft (puros®) and autogenous bone in the treatment of human periodontal intraosseous defects: 6-months follow-up study.
abstract: OBJECTIVE
  Several materials have been introduced as bone grafts, i.e., autografts, allograft, xenografts, and alloplastic grafts, and studies have shown them to produce greater clinical bone defect fill than open flap debridement alone. The aim of this clinical and radiological 6-month study was to compare and evaluate the clinical outcome of deep intraosseous defects following reconstructive surgery with the use of mineralized cancellous bone allograft (Puros®) or autogenous bone.
  
  
  METHODS
  Ten patients with 12 sites exhibiting signs of moderate generalized chronic periodontitis were enrolled in the study. The investigations were confined to two and three-walled intra bony defects with a preoperative probing depth of ≥5 mm. Six of these defects were treated with Puros®(group A) the remaining six were treated with autogenous bone graft (group B). Allocation to the two groups was randomized. The clinical parameters, plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and bone fill, were recorded at different time intervals at the baseline, 1 month, 3 months, and 6 months. Intraoral radiographs were taken using standardized paralleling cone technique at baseline, 1, 3, and 6 months. Statistical analysis was done by using the one-way analysis of variance (ANOVA) followed by Tukey highly significant difference.
  
  
  RESULTS
  Both groups resulted in decrease in probing depth (group A, 3.0 mm; group B, 2.83 mm) and gain in clinical attachment level (group A, 3.33 mm; group B, 3.0 mm) over a period of 6 months, which was statistically insignificant.
  
  
  CONCLUSIONS
  Within the limitations of the present study, it can be concluded that both mineralized cancellous bone allograft (Puros®) or autogenous bone result in significant clinical improvements.
authors.affiliation: Department of Periodontology, Nanded Rural Dental College and Research Centre, Nanded, Maharashtra, India.
authors.forename: B Ravinder
authors.initials: BR
authors.lastname: Reddy
authors.affiliation: Department of Periodontology, G.Pullareddy Dental College, Kurnool, Andhra Pradesh, India.
authors.forename: J
authors.initials: J
authors.lastname: Sudhakar
authors.affiliation: Department of Periodontology, G.Pullareddy Dental College, Kurnool, Andhra Pradesh, India.
authors.forename: Nichenametla
authors.initials: N
authors.lastname: Rajesh
authors.affiliation: Department of Pedodontics, G.Pullareddy Dental College, Kurnool, Andhra Pradesh, India.
authors.forename: V
authors.initials: V
authors.lastname: Sandeep
authors.affiliation: Department of Orthodontics, G.Pullareddy Dental College, Kurnool, Andhra Pradesh, India.
authors.forename: Y Muralidhar
authors.initials: YM
authors.lastname: Reddy
authors.affiliation: Dental Officer, ECHS Polyclinic, Thiruvanammalai, Tamil Nadu, India.
authors.forename: W R
authors.initials: WR
authors.lastname: Gnana Sagar
keywords: Bone substitutes; grafts; intraosseous defects; periodontal disease; periodontal regeneration