title: Self-administered nicotine differentially impacts body weight gain in obesity-prone and obesity-resistant rats.
abstract: Obesity and tobacco smoking represent the largest challenges to public health, but the causal relationship between nicotine and obesity is poorly understood. Nicotine suppresses body weight gain, a factor impacting smoking initiation and the failure to quit, particularly among obese smokers. The impact of nicotine on body weight regulation in obesity-prone and obesity-resistant populations consuming densely caloric diets is unknown. In the current experiment, body weight gain of adult male rats maintained on a high energy diet (31.8% kcal from fat) distributed into obesity-prone (OP), obesity-resistant (OR) and an intermediate group, which was placed on standard rodent chow (Chow). These rats were surgically implanted with intravenous catheters and allowed to self-administer nicotine (0 or 60μg/kg/infusion, a standard self-administration dose) in 1-h sessions for 20 consecutive days. Self-administered nicotine significantly suppressed body weight gain but not food intake in OP and Chow rats. Self-administered nicotine had no effect on body weight gain in OR rats. These data suggest that: 1) OR rats are also resistant to nicotine-induced suppression of body weight gain; and 2) nicotine may reduce levels of obesity in a subset of smokers prone to obesity.
authors.affiliation: Center for Neuroscience at the University of Pittsburgh, A210A Langley Hall, Fifth and Ruskin Avenues, Pittsburgh, PA 15260, United States.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Rupprecht
authors.affiliation: University of Pittsburgh, Department of Psychology, 4119 Sennott Square, 210 South Bouquet Street, Pittsburgh, PA 15260, United States.
authors.forename: Tracy T
authors.initials: TT
authors.lastname: Smith
authors.affiliation: University of Pittsburgh, Department of Psychology, 4119 Sennott Square, 210 South Bouquet Street, Pittsburgh, PA 15260, United States.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Donny
authors.affiliation: Center for Neuroscience at the University of Pittsburgh, A210A Langley Hall, Fifth and Ruskin Avenues, Pittsburgh, PA 15260, United States; University of Pittsburgh, Department of Psychology, 4119 Sennott Square, 210 South Bouquet Street, Pittsburgh, PA 15260, United States; University of Pittsburgh, Department of Neuroscience, A210A Langley Hall, Fifth and Ruskin Avenues, Pittsburgh, PA 15260, United States. Electronic address: sved@pitt.edu.
authors.forename: Alan F
authors.initials: AF
authors.lastname: Sved
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology; D003216:Conditioning, Operant / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D018722:Nicotinic Agonists / Q000008:administration & dosage*; D009765:Obesity / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration
chemical_list: D004041:Dietary Fats; D018722:Nicotinic Agonists; D009538:Nicotine
keywords: Dietary intake; Drugs; Nicotine; Obesity phenotypes