title: Potential of electrolyzed water for disinfection of foot-and-mouth disease virus.
abstract: Acidic electrolyzed water (EW) (pH 2.6-5.8) and alkaline EW (pH 11.2-12.1) were examined as potential disinfectants against foot-and-mouth disease virus (FMDV). Using acidic EW with pH 2.6 and alkaline EW with pH >11.7, the viral titer decreased in vitro by > 4.0 log values, 2 min after the virus was mixed with EW at a 1:10 dilution. The strong virucidal effect of acidic EW (pH 2.6), but not that of alkaline EW (>11.7), seemed to depend on the chlorine level in the solution. Genetic analysis revealed that viral RNA was substantially reduced, especially by alkaline EW.
authors.affiliation: Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan.
authors.forename: Vuong N
authors.initials: VN
authors.lastname: Bui
authors.forename: Khong V
authors.initials: KV
authors.lastname: Nguyen
authors.forename: Nga T
authors.initials: NT
authors.lastname: Pham
authors.forename: Anh N
authors.initials: AN
authors.lastname: Bui
authors.forename: Tung D
authors.initials: TD
authors.lastname: Dao
authors.forename: Thanh T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Hoa T
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Dai Q
authors.initials: DQ
authors.lastname: Trinh
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Inui
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchiumi
authors.forename: Haruko
authors.initials: H
authors.lastname: Ogawa
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Imai
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004202:Disinfectants / Q000737:chemistry / Q000494:pharmacology*; D004572:Electrolysis; D029544:Foot-and-Mouth Disease Virus / Q000187:drug effects*; D016679:Genome, Viral / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D012367:RNA, Viral; D014867:Water / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D004202:Disinfectants; D012367:RNA, Viral; D014867:Water