title: Motor Nerve Conduction Velocity In Postmenopausal Women with Peripheral Neuropathy.
abstract: BACKGROUND
  The post-menopausal phase is characterized by a decline in the serum oestrogen and progesterone levels. This phase is also associated with higher incidence of peripheral neuropathy.
  
  
  OBJECTIVE
  To explore the relationship between the peripheral motor nerve status and serum oestrogen and progesterone levels through assessment of Motor Nerve Conduction Velocity (MNCV) in post-menopausal women with peripheral neuropathy.
  
  
  METHODS
  This cross-sectional study was conducted at Jawaharlal Nehru Medical College during 2011-2013. The study included 30 post-menopausal women with peripheral neuropathy (age: 51.4±7.9) and 30 post-menopausal women without peripheral neuropathy (control) (age: 52.5±4.9). They were compared for MNCV in median, ulnar and common peroneal nerves and serum levels of oestrogen and progesterone estimated through enzyme immunoassays. To study the relationship between hormone levels and MNCV, a stepwise linear regression analysis was done.
  
  
  RESULTS
  The post-menopausal women with peripheral neuropathy had significantly lower MNCV and serum oestrogen and progesterone levels as compared to control subjects. Stepwise linear regression analysis showed oestrogen with main effect on MNCV.
  
  
  CONCLUSIONS
  The findings of the present study suggest that while the post-menopausal age group is at a greater risk of peripheral neuropathy, it is the decline in the serum estrogen levels which is critical in the development of peripheral neuropathy.
authors.affiliation: Senior Resident, Department of Physiology, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Akanksha
authors.initials: A
authors.lastname: Singh
authors.affiliation: Professor, Department of Orthopaedics, J.N. Medical College, Aligarh Muslim University , Aligarh, Uttar Pradesh, India .
authors.forename: Naiyer
authors.initials: N
authors.lastname: Asif
authors.affiliation: Professor and Head, Department of Physiology, G S Medical College , Hapur, Uttar Pradesh, India .
authors.forename: Paras Nath
authors.initials: PN
authors.lastname: Singh
authors.affiliation: Professor, Department of Physiology, J.N. Medical College, Aligarh Muslim University , Aligarh, Uttar Pradesh, India .
authors.forename: Mohd Mobarak
authors.initials: MM
authors.lastname: Hossain
keywords: Hormone replacement therapy; Menopause; Oestrogen; Progesterone