title: Outcomes Following Melody Transcatheter Pulmonary Valve Implantation for Right Ventricular Outflow Tract Dysfunction in Repaired Congenital Heart Disease: First Reported Australian Single Centre Experience.
abstract: BACKGROUND
  Transcatheter pulmonary valve implantation (TPVI) with the Melody® transcatheter pulmonary valve (TPV) has demonstrated good haemodynamic and clinical outcomes in the treatment of right ventricular outflow tract (RVOT) conduit dysfunction in patients with repaired congenital heart disease CHD. We present the first Australian single centre experience of patients treated with Melody TPV.
  
  
  METHODS
  A prospective, observational registry was developed to monitor clinical and haemodynamic outcomes in patients with RVOT dysfunction treated with the Melody TPV (Medtronic Inc, Minneapolis, United States).
  
  
  RESULTS
  Seventeen patients underwent TPVI with Melody TPV at The Prince Charles Hospital between January 2009 and February 2016 with a median (range) age of 34 (R: 15-60). Fifteen (88%) were NYHA Class 2 dyspnoea and 11 (59%) had corrected Tetralogy of Fallot. Indication for TPVI was stenosis in eight (47%), regurgitation in two (12%) and mixed dysfunction in seven (41%). Device implantation was successful in all patients. Peak RVOT gradient was significantly reduced and there was no significant regurgitation post procedure. There was one (6%) major procedural adverse event and two (12%) major adverse events at last recorded follow-up. There were no patient deaths. Follow-up cardiac magnetic resonance imaging revealed a significant reduction in indexed right ventricular end diastolic volume.
  
  
  CONCLUSIONS
  This study confirms the safety and effectiveness of TPVI with Melody TPV for RVOT dysfunction in repaired CHD.
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia; University of Queensland, Brisbane, Qld, Australia. Electronic address: rmarkham19@gmail.com.
authors.forename: Ryan
authors.initials: R
authors.lastname: Markham
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia.
authors.forename: Abhinay
authors.initials: A
authors.lastname: Challa
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Kyranis
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia.
authors.forename: Mugur
authors.initials: M
authors.lastname: Nicolae
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia; University of Queensland, Brisbane, Qld, Australia.
authors.forename: Dale
authors.initials: D
authors.lastname: Murdoch
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia; University of Queensland, Brisbane, Qld, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Savage
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia.
authors.forename: Theresa
authors.initials: T
authors.lastname: Malpas
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia; University of Queensland, Brisbane, Qld, Australia.
authors.forename: Dorothy J
authors.initials: DJ
authors.lastname: Radford
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia; University of Queensland, Brisbane, Qld, Australia; University of Washington, Seattle, WA, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Hamilton-Craig
authors.affiliation: Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia; University of Queensland, Brisbane, Qld, Australia.
authors.forename: Darren L
authors.initials: DL
authors.lastname: Walters
mesh_terms: D000293:Adolescent; D000328:Adult; D006328:Cardiac Catheterization / Q000379:methods*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011664:Pulmonary Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014694:Ventricular Outflow Obstruction / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D055815:Young Adult
keywords: Cardiac catheterisation; Conduit; Heart valve prosthesis; Pulmonary valve implantation