title: Membrane Transport across Polarized Epithelia.
abstract: Polarized epithelial cells line diverse surfaces throughout the body forming selective barriers between the external environment and the internal milieu. To cross these epithelial barriers, large solutes and other cargoes must undergo transcytosis, an endocytic pathway unique to polarized cell types, and significant for the development of cell polarity, uptake of viral and bacterial pathogens, transepithelial signaling, and immunoglobulin transport. Here, we review recent advances in our knowledge of the transcytotic pathway for proteins and lipids. We also discuss briefly the promise of harnessing the molecules that undergo transcytosis as vehicles for clinical applications in drug delivery.
authors.affiliation: Division of Gastroenterology, Boston Children's Hospital, Boston, Massachusetts 02155.
authors.forename: Maria Daniela
authors.initials: MD
authors.lastname: Garcia-Castillo
authors.affiliation: Division of Gastroenterology, Boston Children's Hospital, Boston, Massachusetts 02155.|Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02155.|Department of Pediatrics, Harvard Digestive Diseases Center, Boston, Massachusetts 02155.
authors.forename: Daniel J-F
authors.initials: DJ
authors.lastname: Chinnapen
authors.affiliation: Division of Gastroenterology, Boston Children's Hospital, Boston, Massachusetts 02155.|Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02155.|Department of Pediatrics, Harvard Digestive Diseases Center, Boston, Massachusetts 02155.
authors.forename: Wayne I
authors.initials: WI
authors.lastname: Lencer
mesh_terms: D001692:Biological Transport / Q000502:physiology; D016764:Cell Polarity; D016503:Drug Delivery Systems; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism / Q000502:physiology; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008954:Models, Biological