title: Analysis and follow-up of type 1 choroidal neovascularisation with optical coherence tomography-angiography after antiangiogenic treatment.
abstract: OBJECTIVE
  To describe the characteristics of type 1 choroidal neovascularisation (CNV) in age-related macular degeneration (ARMD) using two different optical coherence tomography angiography (OCT-A) devices sequentially during a standard protocol of three intravitreal injections of an anti-vascular endothelial growth factor (anti-VEGF).
  
  
  METHODS
  The study included 6 eyes with naïve neovascular ARMD. Macular OCT-A images were acquired using AngioPlex Cirrus HD-OCT 5000 (Carl Zeiss Meditec, Inc., Dublin, USA) and DRI OCT Triton SS-OCT Angio (Topcon, Medical Systems, Inc. Oakland, NJ, USA). The macular OCT-A scan covered an area of 3×3mm. Distinct morphological patterns and quantifiable features of the neovascular membranes were studied on en face projection images, which were taken at different stages of the follow-up.
  
  
  RESULTS
  Treatment response could be estimated using the OCT-A criteria of CNV activity. Higher activity scores before treatment resulted in a greater decrease in the membrane area. The estimated net decline in area ranged from 83.5% to 1.4%. The OCT-A performed one-week after treatment revealed the greatest area reductions.
  
  
  CONCLUSIONS
  OCT-A provides new possibilities for the non-invasive assessment of features of neovascular networks and CNV structural morphology. Newly described activity criteria can also guide therapeutic decisions, and help in evaluating responses. Quantitative and qualitative information can be provided with this technique. However, further software development and future investigation are essential to define the role of this tool on a daily basis.
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España. Electronic address: raultorrecillas@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Torrecillas-Picazo
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.
authors.forename: M
authors.initials: M
authors.lastname: Cerdà-Ibáñez
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.
authors.forename: I
authors.initials: I
authors.lastname: Almor Palacios
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Hervás Hernandis
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.
authors.forename: R
authors.initials: R
authors.lastname: Ramón-Cosín
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.
authors.forename: N
authors.initials: N
authors.lastname: Ruiz Del Rio
authors.affiliation: Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.
authors.forename: A
authors.initials: A
authors.lastname: Duch-Samper
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D004867:Equipment Design; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D058449:Intravitreal Injections; D008266:Macula Lutea / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000069579:Ranibizumab / Q000627:therapeutic use*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*; D057135:Wet Macular Degeneration / Q000150:complications*
chemical_list: D020533:Angiogenesis Inhibitors; D000069579:Ranibizumab
keywords: Age-related macular degeneration; Angiografía por tomografía de coherencia óptica; Anti-vascular endothelial growth factor; Antifactor de crecimiento vascular endotelial; Choroidal neovascularisation; Degeneración macular asociada a la edad; Diagnóstico por imagen; Neovascularización coroidea; Optical coherence tomography angiography; Retinal imaging