title: Revisiting the role of Wnt/β-catenin signaling in prostate cancer.
abstract: The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/β-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/β-catenin pathway in prostate cancer and compel us to reexamine the interaction of the AR and Wnt/β-catenin signaling pathways. This review includes newer areas of interest such as non-canonical Wnt signaling and the role of Wnts in prostate cancer stem cells. The effort to develop Wnt modulating therapeutics, both biologics and small molecules, is also discussed.
authors.affiliation: Departments of Urology, Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, United States.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Schneider
authors.affiliation: Departments of Urology, Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, United States. Electronic address: susan.logan@nyumc.org.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Logan
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D011944:Receptors, Androgen / Q000378:metabolism; D015398:Signal Transduction; D060449:Wnt Signaling Pathway
chemical_list: D011944:Receptors, Androgen
keywords: Androgen receptor; Prostate cancer; Wnt signaling; β-catenin