title: Withanolides from aerial parts of Nicandra physalodes.
abstract: Twenty withanolides, including previously unknown nicanlodes A-M, were isolated from aerial parts of Nicandra physalodes. Their structural elucidations were unambiguously achieved through interpretation of extensive spectroscopic data (NMR and HRMS) and by comparison with literature data. Nicanlodes A and B have an unusual aromatic amine moiety. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Graduate University of the Chinese Academy of Sciences, Beijing 100049, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
authors.forename: Mu-Yuan
authors.initials: MY
authors.lastname: Yu
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Gao-Ting
authors.initials: GT
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Jie-Qing
authors.initials: JQ
authors.lastname: Liu
authors.affiliation: Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Afsar
authors.initials: A
authors.lastname: Khan
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
authors.forename: Xing-Rong
authors.initials: XR
authors.lastname: Peng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Jin-Run
authors.initials: JR
authors.lastname: Dong
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: lihaizhou@yninfo.com.
authors.forename: Hai-Zhou
authors.initials: HZ
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China. Electronic address: mhchiu@mail.kib.ac.cn.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Qiu
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D019657:Solanaceae / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D010936:Plant Extracts; D054358:Withanolides
keywords: Cytotoxicity; Nicandra physalodes; Solanaceae; Withanolides