title: Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on CarcinogenesisIn VitroandIn Vivo.
abstract: Cancer is a significant global health concern affecting men and women worldwide. Although current chemopreventive drugs could inhibit the growth of cancer cells, they exert many adverse side effects. Dietary factor plays a crucial role in the management of cancers and has drawn the attention of researchers to be used as an option to combat this disease. Bothin vitroandin vivostudies showed that rice and its by-products display encouraging results in the prevention of this disease. The mechanism of anticancer effect is suggested partly through potentiation of bioactive compounds like vitamin E, phytic acid,γ-aminobutyric acid (GABA),γ-oryzanol, and phenolics. Nevertheless, the bioactivity of rice and its by-products is still incompletely understood. In this review, we present the findings from a preclinical study both inin vitroand in animal experiments on the promising role of rice by-products with focus on cancer prevention.
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Bee Ling
authors.initials: BL
authors.lastname: Tan
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Research Centre of Excellent, Nutrition and Non-Communicable Diseases (NNCD), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Mohd Esa
authors.identifier: 0000-0003-1545-0306
authors.initials: ME
authors.lastname: Norhaizan
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000627:therapeutic use*; D063646:Carcinogenesis / Q000187:drug effects*; D004043:Dietary Fiber / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000178:diet therapy / Q000473:pathology / Q000517:prevention & control*; D012275:Oryza / Q000737:chemistry*; D014866:Waste Products
chemical_list: D016588:Anticarcinogenic Agents; D004043:Dietary Fiber; D014866:Waste Products