title: Dynamics of p53: A Master Decider of Cell Fate.
abstract: Cellular stress-induced temporal alterations-i.e., dynamics-are typically exemplified  by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially  identified as the variations of p53 protein levels. However, a growing number of studies have  shown that p53 dynamics are also manifested in variations in the activity, spatial location, and  posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical  features. These are essential in determining a specific outcome of cell fate. In this review, we  discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate  decision process, as well as their potential applications in p53-based cancer therapy. The review  provides new insights into p53 signaling pathways and their potentials in the development of new  strategies in p53-based cancer therapy.
authors.affiliation: Department of Environmental Health and Occupational Medicine, Sichuan University West China School of Public Health, Chengdu 610041, China. cherry12112009@163.com.|College of Food Science, Sichuan Agricultural University, Yaan 625014, China. cherry12112009@163.com.
authors.forename: Qingyin
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA. jbeav004@fiu.edu.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Beaver
authors.affiliation: Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA. yualiu@fiu.edu.|Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA. yualiu@fiu.edu.|Biomolecular Sciences Institute, School of Integrated Sciences and Humanity, Florida International University, Miami, FL 33199, USA. yualiu@fiu.edu.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Environmental Health and Occupational Medicine, Sichuan University West China School of Public Health, Chengdu 610041, China. zhangzunzhen@163.com.
authors.forename: Zunzhen
authors.initials: Z
authors.lastname: Zhang
keywords: p53 dynamics;  cell fate decision;  cell signaling network