title: The Practical Consideration of Poliovirus as an Oncolytic Virotherapy.
abstract: The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus Chimera (PVSRIPO) has shown promise for the treatment of glioblastoma in clinical trials as well as other cancer types in animal models. In this literature review, we discuss the use of PVSRIPO as an oncolytic virotherapy. In addition to being a potential treatment for glioblastoma, this recombinant virus could possibly be used against other cancers because many tumor cells express the PVSRIPO receptor antigens (CD155) and have a limited ability to control viral replication. Moreover, virus-induced immune responses contribute to the efficacy of PVSRIPO. Given the current trajectory of this experimental therapy, the possibility exists that PVSRIPO will soon be a viable treatment option for various cancer types. While many healthcare providers and cancer patients likely welcome this new viral based treatment, history has taught us that some may be skeptical and avoid its use because of the viral composition of this therapy.
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Denniston
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Hannah
authors.initials: H
authors.lastname: Crewdson
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Rucinsky
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Stegman
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Remenar
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Moio
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Brianne
authors.initials: B
authors.lastname: Clark
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Higginbotham
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Ross
authors.initials: R
authors.lastname: Keffer
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Brammer
authors.affiliation: Department of Graduate Health Sciences, West Liberty University, West Liberty, WV, USA; Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Horzempa
keywords: Glioblastoma; Oncolytic Virology; PVSRIPO; Poliovirus