title: Preparation and biocompatibility of a chitin nanofiber/gelatin composite film.
abstract: The development of chitin-based materials with favorable mechanical properties and biocompatibility is an important research goal owing to the wide-ranging practical applications. In this study, a composite film was prepared using chitin nanofibers and gelatin. The CNF/gelatin composite film was highly viscous and had a fine nanofiber structure. The transmittances indicated high transparency, regardless of nanofiber content. The water content of the CNF/gelatin composite film increased linearly as the gelatin content increased. Although the CNF/gelatin composite film did not induce severe inflammation, it strongly induced fibroblast proliferation, indicating high biocompatibility. Based on these results, the films are suitable for biological applications, e.g., tissue engineering, medicines, and cosmetics.
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan. Electronic address: kazu-azuma@muses.tottori-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Izawa
authors.affiliation: Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ochi
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ito
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saimoto
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan. Electronic address: sifuku@chem.tottori-u.ac.jp.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ifuku
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002686:Chitin / Q000737:chemistry*; D005260:Female; D005780:Gelatin / Q000737:chemistry* / Q000648:ultrastructure; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D057139:Nanofibers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; C015233:gelatin film; D002686:Chitin; D005780:Gelatin
keywords: Chitin nanofiber; Composite; Gelatin