title: Association of Serum Uric Acid Levels with Leg Ischemia in Patients with Peripheral Arterial Disease after Treatment.
abstract: OBJECTIVE
  We investigated the relationships of serum uric acid levels with the progression of atherosclerosis in patients with peripheral arterial disease (PAD) after treatment.
  
  
  METHODS
  Subjects were male patients diagnosed with PAD. Atherosclerosis at the common carotid artery was evaluated based on its intima-media thickness (IMT). Leg arterial flow was evaluated by measuring ankle-brachial index (ABI) and exercise-induced decrease in ABI.
  
  
  RESULTS
  Among various risk factors including age, blood pressure, adiposity, estimated glomerular filtration rate, and blood lipid, blood glucose, uric acid, fibrinogen and C-reactive protein levels, only uric acid levels showed significant correlations with ABI [Pearson's correlation coefficient, -0.292 (p＜0.01)] and leg exercise-induced decrease in ABI [Pearson's correlation coefficient, 0.236 (p＜ 0.05)]. However, there was no significant correlation between uric acid levels and maximum or mean IMT. Odds ratios of subjects with the 3rd tertile versus subjects with the 1st tertile for uric acid levels were significantly higher than the reference level of 1.00 for low ABI [4.44 (95% confidence interval, 1.45-13.65, p＜0.01)] and for high % decrease in ABI after exercise [4.31 (95% confidence interval, 1.34-13.82, p＜0.05)]. The associations of uric acid levels with the indicators of leg ischemia were also found after adjustment for age, history of revascularization therapy, diabetes, smoking, alcohol consumption, body mass index, triglyceride levels, and renal function.
  
  
  CONCLUSIONS
  Uric acid levels are associated with the degree of leg ischemia in patients with PAD. Further interventional studies are needed to determine whether the correction of uric acid levels is effective in preventing the progression of PAD.
authors.affiliation: Department of Cardiovascular Surgery, Yamagata Saisei Hospital.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sotoda
authors.affiliation: Department of Cardiovascular Surgery, Yamagata Saisei Hospital.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hirooka
authors.affiliation: Department of Cardiovascular Surgery, Yamagata Saisei Hospital.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Orita
authors.affiliation: Department of Environmental and Preventive Medicine, Hyogo College of Medicine.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Wakabayashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood*; D059168:Carotid Intima-Media Thickness; D005081:Exercise Therapy; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D007866:Leg / Q000098:blood supply / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood / Q000150:complications* / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: Ankle–brachial index; Atherosclerosis; Diabetes mellitus; Peripheral arterial disease; Uric acid