title: Adamantane in Drug Delivery Systems and Surface Recognition.
abstract: The adamantane moiety is widely applied in design and synthesis of new drug delivery systems and in surface recognition studies. This review focuses on liposomes, cyclodextrins, and dendrimers based on or incorporating adamantane derivatives. Our recent concept of adamantane as an anchor in the lipid bilayer of liposomes has promising applications in the field of targeted drug delivery and surface recognition. The results reported here encourage the development of novel adamantane-based structures and self-assembled supramolecular systems for basic chemical investigations as well as for biomedical application.
authors.affiliation: University of Zagreb, Centre for Research and Knowledge Transfer in Biotechnology, Rockefellerova 10, 10000 Zagreb, Croatia. astimac@unizg.hr.
authors.forename: Adela
authors.initials: A
authors.lastname: Štimac
authors.affiliation: Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. marina.sekutor@irb.hr.
authors.forename: Marina
authors.initials: M
authors.lastname: Šekutor
authors.affiliation: Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. majerski@irb.hr.
authors.forename: Kata
authors.initials: K
authors.lastname: Mlinarić-Majerski
authors.affiliation: Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. frkanec@irb.hr.
authors.forename: Leo
authors.initials: L
authors.lastname: Frkanec
authors.affiliation: University of Zagreb, Centre for Research and Knowledge Transfer in Biotechnology, Rockefellerova 10, 10000 Zagreb, Croatia. rfrkanec@unizg.hr.
authors.forename: Ruža
authors.initials: R
authors.lastname: Frkanec
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D000818:Animals; D003505:Cyclodextrins / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D015394:Molecular Structure; D036103:Nanotechnology
chemical_list: D003505:Cyclodextrins; D050091:Dendrimers; D004337:Drug Carriers; D008081:Liposomes; D000218:Adamantane
keywords: adamantane; cyclodextrins; dendrimers; liposomes; surface recognition; targeted drug delivery