title: Lactic acid bacteria of the Leuconostoc genus with high innate immunity-stimulating activity.
abstract: We screened lactic acid bacteria that exhibited high innate immunity-stimulating activity by monitoring muscle contraction activity in silkworms. Heat-treated fractions of lactic acid bacteria, Leuconostoc carnosum #7-2, Leuconostoc gelidum #4-2, and Leuconostoc mesenteroides 8/11-3, had high (250-460 units/mg) innate immunity-stimulating activity. These lactic acid bacteria proliferated in milk to concentrations of 1 × 106colony forming unit/mL. The present findings suggest that the silkworm muscle contraction assay is useful for screening lactic acid bacteria with high innate immunity-stimulating activity, and that the assay can be used for the production of fermented foods made from milk.
authors.affiliation: Genome pharmaceuticals institute Co. Ltd.
authors.forename: Masaki
authors.initials: M
authors.lastname: Ishii
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishida
authors.forename: Keiko
authors.initials: K
authors.lastname: Kataoka
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D012831:Bombyx; D007113:Immunity, Innate; D007934:Leuconostoc / Q000302:isolation & purification / Q000502:physiology*; D008892:Milk / Q000382:microbiology
chemical_list: D000276:Adjuvants, Immunologic