title: [Characterisation of three polymorphisms of the tryptophan hydroxylase 2 gene in a sample of Colombian population with major depressive disorder].
abstract: OBJECTIVE
  Identify whether rs11179000, rs136494 and rs4570625 polymorphisms of the tryptophan hydroxylase 2 gene, are associated with a major depressive disorder in a sample of the Colombian population.
  
  
  METHODS
  Case-control study was conducted in which a comparison was made between subjects diagnosed with major depressive disorder at some point in adulthood or active symptoms at the time of evaluation, and subjects with no psychiatric disease. Subjects were studied in the Department of Psychiatry, Faculty of Medicine and the Institute of Genetics at the National University of Colombia. Polymorphisms were genotyped using Taqman probes in real time PCR. As well as studying the association between major depressive disorder and these (single nucleotide polymorphisms (SNPs), the association with other factors previously associated with depression were also analysed.
  
  
  RESULTS
  No statistically significant association between genotypic and allelic frequencies of each polymorphism and major depressive disorder was found. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed.
  
  
  CONCLUSIONS
  There was no association between any polymorphism and major depressive disorder.
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Martínez-Idárraga
authors.affiliation: Grupo de Patología Molecular, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Irene
authors.initials: I
authors.lastname: Riveros-Barrera
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sánchez
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Jaramillo
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia. Electronic address: jmcalvog@unal.edu.co.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Calvo-Gómez
authors.affiliation: Grupo de Patología Molecular, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Yunis-Londoño
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D002648:Child; D003105:Colombia; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D055815:Young Adult
chemical_list: C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase
keywords: Genetic variation; Genotipo; Genotype; Major depressive disorder; Polimorfismo de un solo nucleótido; Single nucleotide polymorphism; Trastorno depresivo mayor; Triptófano hidroxilasa 2; Tryptophan hydroxylase 2; Variación genética