title: Dendritic poly-chelator frameworks for multimeric bioconjugation.
abstract: Starting from multifunctional triazacyclononane-triphosphinate chelator cores, dendritic molecules with the ability to bind metal ions within their framework were synthesized. A cooperative interaction of the chelator cages resulted in a markedly increased affinity towards67/68GaIII. A hexameric PSMA inhibitor conjugate with high affinity (IC50= 1.2 nM) and favorable in vivo PET imaging properties demonstrated practical applicability. The novel scaffolds are useful for synthesis of structurally well-defined multimodal imaging probes or theranostics.
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Dominik
authors.initials: D
authors.lastname: Reich
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Wurzer
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Martina
authors.initials: M
authors.lastname: Wirtz
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Veronika
authors.initials: V
authors.lastname: Stiegler
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Spatz
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Julia
authors.initials: J
authors.lastname: Pollmann
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Wester
authors.affiliation: Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, D-85748 Garching, Germany. johannes.notni@tum.de.
authors.forename: Johannes
authors.identifier: http://orcid.org/0000-0002-3964-3391
authors.initials: J
authors.lastname: Notni
mesh_terms: D000818:Animals; D001372:Aza Compounds / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D005710:Gallium Radioisotopes / Q000737:chemistry*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging; D010721:Phosphinic Acids / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D002614:Chelating Agents; D050091:Dendrimers; D005710:Gallium Radioisotopes; D010721:Phosphinic Acids; D010880:Piperidines; D019275:Radiopharmaceuticals; C482777:triazacyclononane