title: Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ).
abstract: Strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non-4-yne (BCN) and surface-bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART-MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.
authors.affiliation: Laboratory of Organic Chemistry, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
authors.forename: Rickdeb
authors.initials: R
authors.lastname: Sen
authors.affiliation: Laboratory of Organic Chemistry, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
authors.forename: Jorge
authors.initials: J
authors.lastname: Escorihuela
authors.affiliation: Laboratory of Organic Chemistry, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
authors.forename: Floris
authors.initials: F
authors.lastname: van Delft
authors.affiliation: Laboratory of Organic Chemistry, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.|Department of Chemical and Materials Engineering, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Han
authors.identifier: 0000-0001-5773-8506
authors.initials: H
authors.lastname: Zuilhof
keywords: cyclooctynes; kinetics; mass spectrometry; metal-free click chemistry; surface chemistry