title: Doubly Regioselective C-H Hydroarylation of Unsymmetrical Alkynes Using Carboxylates as Deciduous Directing Groups.
abstract: A catalyst system composed of [(C6Me6)RuCl2]2, potassium carbonate/guanidine carbonate, and mesitoic acid efficiently promotes the doubly regioselective C-H hydroarylation of unsymmetrical alkynes. The process involves carboxylate-directed ortho-C-H bond activation followed by regioselective addition to the alkyne C-C triple bond with concerted decarboxylation. This action of the carboxylate as a deciduous directing group ensures exclusive monovinylation with high selectivity for the (E)-1,2-diarylalkene.
authors.affiliation: FB Chemie und Forschungszentrum OPTIMAS, Technische Universität Kaiserslautern , Erwin-Schroedinger-Strasse Geb 52-54, 67663 Kaiserslautern, Germany.
authors.forename: Agostino
authors.initials: A
authors.lastname: Biafora
authors.affiliation: Department of Chemistry, University of Azad Jammu and Kashmir , 13100 Muzaffarabad, AJK, Pakistan.
authors.forename: Bilal A
authors.initials: BA
authors.lastname: Khan
authors.affiliation: Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum , Universitätsstrasse 150, 44801 Bochum, Germany.
authors.forename: Janet
authors.initials: J
authors.lastname: Bahri
authors.affiliation: FB Chemie und Forschungszentrum OPTIMAS, Technische Universität Kaiserslautern , Erwin-Schroedinger-Strasse Geb 52-54, 67663 Kaiserslautern, Germany.
authors.forename: Joachim M
authors.initials: JM
authors.lastname: Hewer
authors.affiliation: Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum , Universitätsstrasse 150, 44801 Bochum, Germany.
authors.forename: Lukas J
authors.identifier: 0000-0002-2547-3037
authors.initials: LJ
authors.lastname: Goossen