title: The outcome of short-term low-dose aspirin treatment in Kawasaki disease based on inflammatory markers.
abstract: OBJECTIVE
  Previously, Kawasaki disease (KD) treatment with low-dose aspirin was administered for 6-8 weeks after the acute phase. However, inflammatory marker levels normalize before 6-8 weeks. In this study, we aimed to investigate the clinical outcome of short-term low-dose aspirin treatment based on inflammatory and thrombotic marker levels.
  
  
  METHODS
  We performed a retrospective review of the medical records of patients with KD who were hospitalized at Chungnam National University Hospital between September 2012 and May 2014. When fever subsided, low-dose aspirin treatment was started. Inflammatory (white blood cell count, erythrocyte sedimentation rate, and C-reactive protein) and thrombotic markers (D-dimer) were monitored at follow-ups conducted in 1- to 2-week intervals. The low-dose aspirin administration was terminated when both markers were normalized and no cardiovascular complications were observed.
  
  
  RESULTS
  Eighty-four patients with KD (complete KD, n=49; incomplete KD, n=35) were enrolled. The inflammatory and thrombotic marker levels were normalized within 3-4 weeks on average. At the beginning the low-dose aspirin treatment, 9 patients had coronary artery lesions but 75 did not. When the low-dose aspirin administration was terminated at the time the inflammatory marker levels were normalized, no new CALs developed during the follow-up at 6-8 weeks.
  
  
  CONCLUSIONS
  Most of the inflammatory marker levels were normalized within 3-4 weeks after the acute phase of KD. New cardiovascular complications did not develop during the course of the short-term aspirin treatment based on the inflammatory marker levels, clinical findings, and echocardiography.
authors.affiliation: Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Yoo
authors.affiliation: Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Ji Mok
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Hong Ryang
authors.initials: HR
authors.lastname: Kil
keywords: Aspirin; Inflammation; Kawasaki disease