title: Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics.
abstract: The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.
authors.affiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, MN, 55455-0132, USA.
authors.forename: Arpan A
authors.initials: AA
authors.lastname: Bandyopadhyay
authors.affiliation: Biological Process Development, Bristol Myers Squibb, 521 NJ-173, Bloomsbury, NJ, 08804, USA.
authors.forename: Anurag
authors.initials: A
authors.lastname: Khetan
authors.affiliation: AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Malmberg
authors.affiliation: WuXi AppTec, Pudongxin District, Shanghai, China.
authors.forename: Weichang
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, MN, 55455-0132, USA. acre@cems.umn.edu.
authors.forename: Wei-Shou
authors.identifier: 0000-0002-5964-2900
authors.initials: WS
authors.lastname: Hu
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000096:biosynthesis*; D001688:Biological Products / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods* / Q000639:trends; D018929:Cell Culture Techniques / Q000379:methods*; D006801:Humans; D007218:Industrial Microbiology / Q000379:methods* / Q000639:trends; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics
chemical_list: D001685:Biological Factors; D001688:Biological Products; D011994:Recombinant Proteins
keywords: Natural products; Process technology; Protein biologics