title: RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways.
abstract: The innate immune sensing of pathogens is important for host to mount defensive responses. STING has emerged in recent years as a critical signaling adaptor in the immune response to cytosolic DNA and RNA derived from pathogens. Liuet al.(2016) demonstrate that the RIG-I-dependent RNA sensing signaling induces STING expression via a TNF-α and IFN-α synergy. The up-regulation of STING is vital for 5'pppRNA restriction of HSV, a DNA virus that infects humans and causes herpes,in vitroandin vivo. This study provides new insights into the cross talk between DNA and RNA pathogen-sensing systems via the control of STING.
authors.affiliation: Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, H3T 1E2 CANADA; Department of Medicine, McGill University, Montreal, H3T 1E2 CANADA.
authors.forename: Yiliu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, H3T 1E2 CANADA; Department of Medicine, McGill University, Montreal, H3T 1E2 CANADA; Department of Microbiology & Immunology, McGill University, Montreal, H3T 1E2 CANADA.
authors.forename: Rongtuan
authors.initials: R
authors.lastname: Lin
authors.affiliation: Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, H3T 1E2 CANADA; Department of Medicine, McGill University, Montreal, H3T 1E2 CANADA; Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, 8000 Aarhus C DENMARK.
authors.forename: David
authors.initials: D
authors.lastname: Olagnier
keywords: 5′pppRNA; HSV; MAVS; RIG-I; RIG-I agonist; STING; antiviral response; cGAS; innate immunity; type I IFN