title: Unusual onset of adult still's disease due to a systemic reaction to artificial breast implants.
abstract: In this manuscript, we report an exceptional observation study of a young woman suffering from an autoimmune syndrome induced by adjuvants (ASIA). Until today only seven cases of adult-onset Still's disease (AOSD) induced by breast implants have been published. This may be due to the fact that this illness itself is very rare; however, the reason might also be that the community is not sensitized to the case-specific symptoms. Within this article, we show for the first time highly detailed diagnostic test procedures such as PET-CT scans and specific histological staining of the breast tissue, displaying proinflammatory macrophages that are a well-known activator and booster of autoimmune diseases. We hope to give new insights into the clinical picture and pathogenesis of AOSD in order to improve the challenging diagnosis.
authors.affiliation: Department of Internal Medicine III, RWTH University-Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. awehr@ukaachen.de.
authors.forename: A
authors.initials: A
authors.lastname: Wehr
authors.affiliation: Department of Plastic Surgery, Hospital Havelhöhe, Kladower Damm 221, 14089, Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Grieb
authors.affiliation: Department of Internal Medicine III, RWTH University-Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Trautwein
authors.affiliation: Department of Internal Medicine III, RWTH University-Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Streetz
mesh_terms: D000276:Adjuvants, Immunologic; D000328:Adult; D001327:Autoimmune Diseases; D018427:Breast Implants / Q000009:adverse effects; D005260:Female; D006801:Humans; D000072078:Positron Emission Tomography Computed Tomography; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis / Q000209:etiology
chemical_list: D000276:Adjuvants, Immunologic
keywords: Adult-onset rheumatoid arthritis; Autoimmune diseases; Diagnostic imaging; Histology; Silicone