title: Recent Progress in Alzheimer's Disease Research, Part 2: Genetics and Epidemiology.
abstract: This is the second part of a three-part review series reviewing the most important advances in Alzheimer's disease (AD) research since 2010. This review covers the latest research on genetics and epidemiology. Epidemiological and genetic studies are revealing important insights into the etiology of, and factors that contribute to AD, as well as areas of priority for research into mechanisms and interventions. The widespread adoption of genome wide association studies has provided compelling evidence of the genetic complexity of AD with genes associated with such diverse physiological function as immunity and lipid metabolism being implicated in AD pathogenesis.
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, ON, Canada.
authors.forename: Morgan
authors.initials: M
authors.lastname: Robinson
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, ON, Canada.
authors.forename: Brenda Y
authors.initials: BY
authors.lastname: Lee
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, ON, Canada.|Department of Chemistry, Lakehead University, Thunder Bay, ON, Canada.|Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada.
authors.forename: Francis T
authors.initials: FT
authors.lastname: Hane
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D000818:Animals; D006801:Humans
keywords: APOE; Alzheimer’s disease; amyloid precursor protein; epidemiology; factors; genetics