title: Synchronous Aberrant Cerebellar and Opercular Development in Fetuses and Neonates with Congenital Heart Disease: Correlation with Early Communicative Neurodevelopmental Outcomes, Initial Experience.
abstract: Patients with congenital heart disease (CHD) demonstrate multidomain cognitive delays. Cingulo-opercular and cerebellar brain networks are critical to language functions. This is a description of our initial experience aiming to identify an anatomic correlate for CHD patients with expressive language delays. Fetal CHD patients, prospectively enrolled, underwent serial fetal (1.5T), postnatal pre- and postoperative (3T) MRI. Non-CHD patients were enrolled retrospectively from the same epoch. Comparable fetal and neonatal T2 contrast was used for manual linear cross-sectional measurement. Multivariable analysis was used for adjustments and curve fitting. Neurodevelopment was assessed with Battelle Developmental Inventory, 2nd ed. between 9 and 36 months of age. This interim analysis included patients from our longitudinal CHD study who had fetal, postnatal imaging and neurodevelopmental data-yielding a total of 62 mothers (11 CHD fetuses and 51 non-CHD fetuses). Altered brain trajectories were seen in selected cerebellar and opercular measurements in CHD patients compared with the non-CHD group. Smaller inferior cerebellar vermis measurements were associated with multiple communication-related abnormalities. Altered early structural development of the cerebellum and operculum is present in patients with CHD, which correlates with specific neurodevelopmental abnormalities.
authors.affiliation: New York Medical College, Valhalla, New York.
authors.forename: A
authors.initials: A
authors.lastname: Wong
authors.affiliation: Division of Neonatology, University Southern California, Children's Hospital Los Angeles Center for Fetal and Neonatal Medicine, Los Angeles, California.
authors.forename: T
authors.initials: T
authors.lastname: Chavez
authors.affiliation: Division of Neurology, University Southern California, Children's Hospital Los Angeles, Los Angeles, California.
authors.forename: S
authors.initials: S
authors.lastname: O'Neil
authors.affiliation: Division of Cardiology, University Southern California, Children's Hospital Los Angeles, Los Angeles, California.
authors.forename: J
authors.initials: J
authors.lastname: Votava-Smith
authors.affiliation: Division of Obstetrics/Gynecology, University Southern California, Children's Hospital Los Angeles Center for Fetal and Neonatal Medicine, Los Angeles, California.
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.affiliation: Division of Anesthesiology Critical Care Medicine, University Southern California, Children's Hospital Los Angeles, Los Angeles, California.
authors.forename: S
authors.initials: S
authors.lastname: delCastillo
authors.affiliation: Department of Radiology, University of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.
authors.forename: A
authors.initials: A
authors.lastname: Panigrahy
authors.affiliation: Division of Neonatology, University Southern California, Children's Hospital Los Angeles Center for Fetal and Neonatal Medicine, Los Angeles, California.
authors.forename: L
authors.initials: L
authors.lastname: Paquette
keywords: brain growth; communication; congenital heart disease; fetus; neonate; neurodevelopment