title: Comorbid course of coronary heart disease and hypertension in residents of mountain areas of Transcarpathion region that had normal or slightly abnormal coronary arteriograms.
abstract: BACKGROUND
  coronary heart disease and hypertension are prominent in the structure of morbidity and mortality in Ukraine, and these indicators have tended to increase. The proportion of patients with myocardial infarction with normal or close to normal coronary arteries according to coronary angiography, according to various sources, ranging from 1 to 12%.
  
  
  OBJECTIVE
  set the clinical course of CHD in the background of arterial hypertension of residents in the mountainous areas of Transcarpathion region.
  
  
  METHODS
  all patients performed general clinical, laboratory, echocardiographic examination by the standard method and coronary angiography.
  
  
  RESULTS
  study groups did not significantly differ in key demographic and clinical data. Mountain residents with myocardial infarction were also almost 9 years younger than lowland residents.Analysis of intracardiac hemodynamics revealed no significant differences except more important dimensions of left atrium and higher indices of diastolic left ventricular function in Highlanders. Concusions: in Highlanders MI occurs at a younger age than in lowland inhabitants. Also, in Highlanders were found trends towards lower values of serum creatinine. Miocardial infarction occurred much less in mountain residents. Hemodynamics in Highlanders characterized by a larger sizes of left atrium and higher rates of diastolic left ventricular function.
authors.affiliation: Uzhgorod National University, Medical Department, Uzhgorod, Ukraine.
authors.forename: Olena V
authors.initials: OV
authors.lastname: Ustych
authors.affiliation: Uzhgorod National University, Medical Department, Uzhgorod, Ukraine.
authors.forename: Mykola V
authors.initials: MV
authors.lastname: Rishko
authors.affiliation: Uzhgorod National University, Medical Department, Uzhgorod, Ukraine.
authors.forename: Oleksandr O
authors.initials: OO
authors.lastname: Kutsyn
mesh_terms: D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology*; D003971:Diastole; D006325:Heart Atria / Q000033:anatomy & histology; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008875:Middle Aged; D014455:Ukraine / Q000453:epidemiology; D016277:Ventricular Function, Left
keywords:  coronary angiography ;  hypertension;  mountainous areas of Transcarpathion region;  normal coronary arteries; ischemic heart disease