title: ASSOCIATION BETWEEN TANGENTIAL CONTRACTION AND EARLY VISION LOSS IN IDIOPATHIC EPIRETINAL MEMBRANE.
abstract: OBJECTIVE
  To investigate the clinical features associated with early visual loss in patients with idiopathic epiretinal membrane.
  
  
  METHODS
  Patients with idiopathic epiretinal membrane with visual acuity of ≥20/40, intact ellipsoid zone, and follow-up duration of at least 24 months were included in this retrospective age-matched control study. The disk-fovea-vascular (DFV) distance, central macular thickness, membrane configuration, and ellipsoid zone were assessed using fundus photography and spectral domain optical coherence tomography.
  
  
  RESULTS
  We analyzed the progression group (n = 15; vision loss ≥2 lines because of membrane progression) and the control group (n = 30; age matched). Compared with the controls, the mean DFV distance decreased (P < 0.001), central macular thickness increased (P = 0.017), and the ratio of the follow-up and baseline DFV distances (traction index of membrane) was significantly lower (P = 0.001) in the progression group. No differences were observed in the follow-up membrane configuration and ellipsoid zone. Factors associated with early vision loss were the DFV distance change (ρ = 0.657; P = 0.008) and traction index of membrane (ρ = -0.636; P = 0.011). Their area under receiver-operating characteristic curves were significant (DFV distant change: 0.915, traction index of membrane: 0.910, respectively; P < 0.001, both).
  
  
  CONCLUSIONS
  Assessing the DFV distance is useful in quantifying the tangential contraction of macula and the prediction of vision loss in idiopathic epiretinal membrane.
authors.affiliation: Department of Ophthalmology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Seung Min
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Kang Yeun
authors.initials: KY
authors.lastname: Pak
authors.affiliation: Department of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors.forename: Han Jo
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: Department of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.|College of Medicine, Pusan National University, Yangsan, Korea.
authors.forename: Sung Who
authors.initials: SW
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.|College of Medicine, Pusan National University, Yangsan, Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.|College of Medicine, Pusan National University, Yangsan, Korea.
authors.forename: Ik Soo
authors.initials: IS
authors.lastname: Byon
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D019773:Epiretinal Membrane / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology*