title: Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum.
abstract: Cancer is one of the most common lethal diseases, and natural products have been extensively studied as anticancer agents considering their availability, low toxicity, and economic affordability. Plants belonging to the genusAconitumhave been widely used medically in many Asian countries since ancient times. These plants have been proven effective for treating several types of cancer, such as lung, stomach, and liver cancers. The main effective components ofAconitumplants are diterpenoid alkaloids-which are divided into C18-, C19-, C20-, and bis-diterpenoid alkaloids-are reportedly some of the most promising, naturally abundant compounds for treating cancer. This review focuses on the progress of diterpenoid alkaloids with different structures derived fromAconitumplants and some of their derivatives with potential anticancer activities. We hope that this work can serve as a reference for further developingAconitumditerpenoid alkaloids as anticancer agents.
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. Rmy0711@163.com.|Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou 510515, China. Rmy0711@163.com.
authors.forename: Meng-Yue
authors.initials: MY
authors.lastname: Ren
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. dkdklm@163.com.|Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou 510515, China. dkdklm@163.com.
authors.forename: Qing-Tian
authors.initials: QT
authors.lastname: Yu
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. 15626452676@163.com.|Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou 510515, China. 15626452676@163.com.
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Shi
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. ljb@smu.edu.cn.|Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou 510515, China. ljb@smu.edu.cn.
authors.forename: Jia-Bo
authors.initials: JB
authors.lastname: Luo
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D004224:Diterpenes
keywords: anticancer; diterpenoid alkaloids; genus Aconitum