title: The measurement of DLNO and DLCO: A manufacturer's perspective.
abstract: The simultaneous measurement of the lung transfer factor for carbon monoxide (DLCO) and nitric oxide (DLNO) is now available as a powerful method for studying the alveolar-capillary gas exchange. However, application of the DLNO-CO technique in daily settings is still limited by some technical drawbacks. This paper provides a manufacturer's overview of the measuring principles, technical challenges and current available solutions for implementing the DLNO-CO measurement in to a marketed device. This includes the recent developments in technology for NO sensors, latest findings on NO uptake and new statistical methods.
authors.affiliation: Medisoft-MGCD, Sorinnes, Belgium.
authors.forename: X
authors.initials: X
authors.lastname: Giraud
authors.affiliation: RespiSom Private Research Medical Center, Namur, Belgium. Electronic address: ledongnhatnam@yahoo.com.
authors.forename: N N
authors.initials: NN
authors.lastname: Le-Dong
authors.affiliation: Medisoft-MGCD, Sorinnes, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Hogben
authors.affiliation: CHU-UCL Namur, Place Louise Godin 15, 5000, Namur, Belgium.
authors.forename: J B
authors.initials: JB
authors.lastname: Martinot
mesh_terms: D002248:Carbon Monoxide / Q000032:analysis*; D004867:Equipment Design; D006801:Humans; D009569:Nitric Oxide / Q000032:analysis*; D011653:Pulmonary Diffusing Capacity / Q000295:instrumentation* / Q000379:methods
chemical_list: D009569:Nitric Oxide; D002248:Carbon Monoxide
keywords: Gas sensor; Lung transfer factor; Medical instrument industry; Nitric oxide