title: [Biological therapies in otology. German version].
abstract: Millions of people worldwide suffer from hearing loss. Current treatment for patients with severe to profound hearing loss consists of cochlear implants. Providing the cochlear nerve is intact, patients generally benefit enormously from this intervention, frequently achieving significant improvements in speech comprehension. There are, however, some cases where current technology does not provide patients with adequate benefit. New therapeutic concepts based on cell transplantation and gene therapy are developing rapidly, at least in the research sector. Compared to the wealth of basic research available in this area, translation of these new experimental approaches into clinical application is presently at a very early stage. The current review focuses on translatable treatment concepts and discusses the barriers that need to be overcome in order to translate basic scientific research into clinical reality. Furthermore, the first examples of clinical application of biological therapies in severe hearing loss are presented, particularly in connection with cochlear implants.
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde OE 6500 Hannover Medical School, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. roemer.ariane@mh-hannover.de.
authors.forename: A
authors.initials: A
authors.lastname: Roemer
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA.
authors.forename: H
authors.initials: H
authors.lastname: Staecker
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde OE 6500 Hannover Medical School, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Sasse
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde OE 6500 Hannover Medical School, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Lenarz
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde OE 6500 Hannover Medical School, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Warnecke
mesh_terms: D001691:Biological Therapy; D019929:Cochlear Implantation; D003054:Cochlear Implants; D034381:Hearing Loss / Q000628:therapy; D006801:Humans; D013067:Speech Perception
keywords: Cell- and Tissue-Based Therapy; Cochlear implantats; Neuroprotection; Otologic surgical procedures; Polyphenols