title: Merging Photoredox with Copper Catalysis: Decarboxylative Alkynylation of α-Amino Acid Derivatives.
abstract: A novel and efficient decarboxylative alkynylation of N-(acetoxy)phthalimides of α-amino acids with terminal alkynes has been developed by merging photoredox with copper catalysis at room temperature, and the reaction provided the valuable propargylamines in good to excellent yields with assistance of [Ru(bpy)3]Cl2/CuI and visible light. The simple protocol, mild reaction conditions, and high efficiency of this method make it an important strategy for synthesis of diverse molecules containing amino acid fragments.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Pengxiang
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Yang
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Hua
authors.identifier: 0000-0001-7250-0053
authors.initials: H
authors.lastname: Fu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D015394:Molecular Structure; D010084:Oxidation-Reduction; D055668:Photochemical Processes
chemical_list: D000596:Amino Acids; D003300:Copper