title: Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond.
abstract: Since they were identified in 1975, human astroviruses have been considered one of the most important agents of viral acute gastroenteritis in children. However, highly divergent astroviruses infecting humans have been recently discovered and associated with extra-intestinal infections. The report of cases of fatal meningitis and encephalitis, especially in immunocompromised individuals, has broadened their disease spectrum. Although zoonotic transmission among animal and human astroviruses has not been clearly recognized, the genetic similarity between some human and animal viruses makes it likely to occur. This review provides an update on the epidemiology of both classic and novel human astroviruses, and a comprehensive view on confirmed or potential association between astrovirus and human disease.
authors.affiliation: Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona 08028, Spain. Diem-Lan.Vu@hcuge.ch.|Nutrition and Food Safety Research Institute (INSA-UB), University of Barcelona, Santa Coloma de Gramenet 08921, Spain. Diem-Lan.Vu@hcuge.ch.
authors.forename: Diem-Lan
authors.initials: DL
authors.lastname: Vu
authors.affiliation: Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona 08028, Spain. abosch@ub.edu.|Nutrition and Food Safety Research Institute (INSA-UB), University of Barcelona, Santa Coloma de Gramenet 08921, Spain. abosch@ub.edu.
authors.forename: Albert
authors.initials: A
authors.lastname: Bosch
authors.affiliation: Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona 08028, Spain. rpinto@ub.edu.|Nutrition and Food Safety Research Institute (INSA-UB), University of Barcelona, Santa Coloma de Gramenet 08921, Spain. rpinto@ub.edu.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Pintó
authors.affiliation: Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona 08028, Spain. susanaguix@ub.edu.|Nutrition and Food Safety Research Institute (INSA-UB), University of Barcelona, Santa Coloma de Gramenet 08921, Spain. susanaguix@ub.edu.
authors.forename: Susana
authors.initials: S
authors.lastname: Guix
mesh_terms: D004660:Encephalitis / Q000453:epidemiology / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D001257:Mamastrovirus / Q000145:classification* / Q000302:isolation & purification*; D008581:Meningitis / Q000453:epidemiology / Q000821:virology
keywords: astrovirus; encephalitis; epidemiology; gastroenteritis; meningitis; zoonosis