title: Linking Pluripotency Reprogramming and Cancer.
abstract: Tumor development and the generation of induced pluripotent stem cells are highly comparable processes with striking similarities. Cellular plasticity is inherent to tumor evolution, rendering cells that acquire a stem cell-like phenotype, for which Sox2 activation has proved instrumental for the plastic acquisition of stemness properties in tumor cells. Understanding the molecular mechanisms underlying both events might uncover novel approaches for the development of anticancer therapeutics and constitute model systems for understanding tumor generation and ensuring the biosafety of cell-based therapies. Stem Cells Translational Medicine 2017;6:335-339.
authors.affiliation: Synpromics Ltd., Edinburgh, United Kingdom.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Iglesias
authors.affiliation: StemTek Therapeutics, Bilbao, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Gumuzio
authors.affiliation: StemTek Therapeutics, Bilbao, Spain.
authors.forename: Angel G
authors.initials: AG
authors.lastname: Martin
mesh_terms: D000818:Animals; D002465:Cell Movement; D000066670:Cell Plasticity; D049109:Cell Proliferation; D065150:Cellular Reprogramming; D000067470:Cellular Reprogramming Techniques; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D055748:SOXB1 Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors