title: Successful treatment of a metastatic, gastrointestinal stromal tumour in a dog with toceranib phosphate (Palladia).
abstract: A ten-year-old, female-entire English springer spaniel presented with a large intra-abdominal mass but no other clinical signs. Gastrointestinal stromal tumour of the caecum with widespread abdominal metastasis was confirmed. Treatment with toceranib phosphate resulted in complete response, despite the absence of exon-8 or exon-11 c-kit mutation. There was no clinical evidence of tumour recurrence nine months after diagnosis.
authors.affiliation: Willows Referral Service, Solihull, B90 4NH.
authors.forename: J W
authors.initials: JW
authors.lastname: Elliott
authors.affiliation: Willows Referral Service, Solihull, B90 4NH.
authors.forename: F
authors.initials: F
authors.lastname: Swinbourne
authors.affiliation: Willows Referral Service, Solihull, B90 4NH.
authors.forename: A
authors.initials: A
authors.lastname: Parry
authors.affiliation: Willows Referral Service, Solihull, B90 4NH.
authors.forename: L
authors.initials: L
authors.lastname: Baines
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000662:veterinary*; D007211:Indoles / Q000627:therapeutic use*; D009154:Mutation; D009364:Neoplasm Recurrence, Local; D019009:Proto-Oncogene Proteins c-kit; D011758:Pyrroles / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; C464577:toceranib phosphate; D019009:Proto-Oncogene Proteins c-kit