title: Palladium-Catalyzed Oxidative Cascade Carbonylative Spirolactonization of Enallenols.
abstract: A highly selective palladium-catalyzed oxidative carbonylation/carbocyclization/alkoxycarbonylation of enallenols to afford spirolactones bearing an all-carbon quaternary center was developed. This transformation involves the overall formation of three C-C bonds and one C-O bond through a cascade insertion of carbon monoxide (CO), an olefin, and CO. Preliminary experiments on chiral anion-induced enantioselective carbonylation/carbocyclization of enallenols afforded spirolactones with moderate enantioselectivity.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Youai
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Tuo
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Can
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Jan-E
authors.identifier: 0000-0001-8462-4176
authors.initials: JE
authors.lastname: Bäckvall
keywords: carbocyclization; enallenols; oxidation; palladium; spirolactones