title: N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles.
abstract: A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India. surisetti@iict.res.in suresh.surisetti@yahoo.in and Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India.
authors.forename: Battu
authors.initials: B
authors.lastname: Harish
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India. surisetti@iict.res.in suresh.surisetti@yahoo.in.
authors.forename: Manyam
authors.initials: M
authors.lastname: Subbireddy
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India. surisetti@iict.res.in suresh.surisetti@yahoo.in and Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India.
authors.forename: Surisetti
authors.identifier: http://orcid.org/0000-0003-0202-5781
authors.initials: S
authors.lastname: Suresh