title: Vitiligo susceptibility and catalase gene polymorphisms in Sicilian population.
abstract: BACKGROUND
  Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in vitiligo patients. Catalase is a well-known oxidative stress regulator that could play an important role in the pathogenesis of vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with vitiligo susceptibility in Sicilian population.
  
  
  METHODS
  Sixty out of 73 Sicilian patients with vitiligo were enrolled and submitted to CAT gene analysis.
  
  
  RESULTS
  Contrary to the Northern part of Europe but likewise to the Mediterranean area, the frequency of the CAT genotypes in Sicily is equally distributed. Out of all CAT genotypes, only CAT-89 T/T frequency was found to be significantly higher amongst vitiligo patients than controls.
  
  
  CONCLUSIONS
  Despite the involvement of the CAT enzyme in the pathogenesis of vitiligo, the biological significance of CAT gene polymorphisms is still controversial. With the only exception for CAT variant -89A/T, the other studied CAT gene polymorphisms (389C/T and 419C/T) might not to be associated with vitiligo in Sicilian population.
authors.affiliation: Department of Dermatology, University of Palermo, Palermo, Italy - valentina.caputo@unipa.it.
authors.forename: Valentina
authors.initials: V
authors.lastname: Caputo
authors.affiliation: Laboratory of Molecular Genetics, Villa Sofia V. Cervello Hospital, Palermo, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Niceta
authors.affiliation: Department of Dermatology, University of Palermo, Palermo, Italy.
authors.forename: Santi
authors.initials: S
authors.lastname: Fiorella
authors.affiliation: Department of Dermatology, University of Palermo, Palermo, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: La Vecchia
authors.affiliation: Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics, San Gallicano Dermatologic Institute (IRCCS), Rome, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Bastonini
authors.affiliation: Department of Dermatology, University of Palermo, Palermo, Italy.
authors.forename: Maria R
authors.initials: MR
authors.lastname: Bongiorno
authors.affiliation: Department of Dermatology, University of Palermo, Palermo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pistone
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002374:Catalase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012802:Sicily; D014820:Vitiligo / Q000235:genetics*; D055815:Young Adult
chemical_list: D006861:Hydrogen Peroxide; D002374:Catalase