title: Effect of Thai banana (Musa AA group) in reducing accumulation of oxidation end products in UVB-irradiated mouse skin.
abstract: METHODS
  Chronic UVB exposure causes skin disorders and cancer through DNA strand breaks and oxidation of numerous functional groups of proteins and lipids in the skin. In this study, we investigated the effects of Thai banana (Musa AA group, "Khai," and Musa ABB group, "Namwa") on the prevention of UVB-induced skin damage when fed to male ICR mice.
  
  
  RESULTS
  Mice were orally fed banana (Khai or Namwa) fruit pulps at dose of 1mg/g body weight/day for 12weeks. The shaved backs of the mice were irradiated with UVB for 12weeks. The intensity dose of UVB-exposure was increased from 54mJ/cm2/exposure at week 1 to 126mJ/cm2/exposure at week 12. A significant increase in skin thickness, lipid peroxidation, protein oxidation end products, and expression of MMP-1 was observed in UVB-irradiated mouse skin. A reduction in the accumulation of oxidation end products was found in the skin of UVB-irradiated mice receiving Khai. This occurred in conjunction with a reduction in MMP-1 expression, inhibition of epidermal thickening, and induction of γ-GCS expression.
  
  
  CONCLUSIONS
  The dietary intake of Khai prevented skin damage from chronic UVB exposure by increased γ-GCS expression and reduced oxidation end products included carbonyls, malondialdehyde and 4-hydroxynonenal.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Nontaphat
authors.initials: N
authors.lastname: Leerach
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Swanya
authors.initials: S
authors.lastname: Yakaew
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Preeyawass
authors.initials: P
authors.lastname: Phimnuan
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Wichuda
authors.initials: W
authors.lastname: Soimee
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Wongnapa
authors.initials: W
authors.lastname: Nakyai
authors.affiliation: Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Witoo
authors.initials: W
authors.lastname: Luangbudnark
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand. Electronic address: jarupav@nu.ac.th.
authors.forename: Jarupa
authors.initials: J
authors.lastname: Viyoch
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004817:Epidermis / Q000473:pathology / Q000528:radiation effects; D015227:Lipid Peroxidation; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D028521:Musa / Q000378:metabolism*; D010084:Oxidation-Reduction; D012867:Skin / Q000293:injuries / Q000378:metabolism / Q000528:radiation effects*; D013785:Thailand; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D053509:Matrix Metalloproteinase 13; C507081:Mmp13 protein, mouse
keywords: Lipid peroxidation; Musa AA group; Musa ABB group; Protein oxidation; UVB-induced skin damage