title: MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature.
abstract: BACKGROUND
  Miller Fisher syndrome (MFS) is a rare demyelinating condition which may have involvement of cranial nerves. There are a few case reports of optic pathway involvement in children. We describe 3 patients with optic pathway enhancement in pediatric patients with MFS.
  
  
  METHODS
  We retrospectively reviewed brain imaging findings in 17 pediatric patients with of Guillain-Barré syndrome (GBS) meeting Brighton criteria who had brain MRIs performed during their acute illness. Cranial nerve enhancement was seen in 6/17 patients and optic nerve/chiasm enhancement was seen in 3 patients.
  
  
  CONCLUSIONS
  Cranial nerve enhancement and optic pathway in particular, can be seen in patients with MFS. Imaging findings do not always correlate with clinical manifestations of cranial nerve involvement.
authors.affiliation: Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar St, New Haven, CT 06520-8042, United States. Electronic address: ajay.malhotra@yale.edu.
authors.forename: Ajay
authors.initials: A
authors.lastname: Malhotra
authors.affiliation: Griffith University, Brisbane, Australia. Electronic address: mia.zhang.m@gmail.com.
authors.forename: Mia
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States. Electronic address: xiao.wu@yale.edu.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wu
authors.affiliation: University of North Carolina, School of Public Health, Chapel Hill, NC, United States. Electronic address: s_jindal3@yahoo.com.
authors.forename: Shanu
authors.initials: S
authors.lastname: Jindal
authors.affiliation: Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States. Electronic address: david.durand@yale.edu.
authors.forename: David
authors.initials: D
authors.lastname: Durand
authors.affiliation: Department of Pediatrics (Neurology) and of Neurology, Yale School of Medicine, New Haven, CT, United States. Electronic address: naila.makhani@yale.edu.
authors.forename: Naila
authors.initials: N
authors.lastname: Makhani
mesh_terms: D000293:Adolescent; D001933:Brain Stem / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D003391:Cranial Nerves / Q000000981:diagnostic imaging; D005260:Female; D020275:Guillain-Barre Syndrome / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D019846:Miller Fisher Syndrome / Q000000981:diagnostic imaging* / Q000628:therapy; D059906:Neuroimaging / Q000379:methods; D009897:Optic Chiasm / Q000000981:diagnostic imaging*; D012189:Retrospective Studies
keywords: Guillain–Barré syndrome; MRI; Miller Fisher syndrome; Optic involvement