title: Serum Triglyceride Lowering Effect of Cilnidipine in Patients With Essential Hypertension.
abstract: BACKGROUND
  Many epidemiological studies have established the relationship between hypertension and dyslipidemia. Calcium channel blockers (CCBs) are one of the first-line drugs for newly diagnosed patients with essential hypertension. Cilnidipine as a newer CCB acting by blocking both L- and N-type calcium channels possesses additional beneficial effects apart from lowering blood pressure (BP). The aim of this study was to evaluate the effectiveness of cilnidipine in patients with essential hypertension with borderline dyslipidemia and its effects on lipid profile.
  
  
  METHODS
  Out of 45 enrolled patients, who fulfilled the inclusion criteria, only 37 completed the study. Cilnidipine was started at 10 mg/day, and then adjusted to 5 - 20 mg/day to achieve the target blood pressure.
  
  
  RESULTS
  After 12 weeks of study, patients showed significant reduction in systolic blood pressure, diastolic blood pressure, mean BP, heart rate and serum triglyceride level from baseline values (P < 0.00).
  
  
  CONCLUSIONS
  In clinical setting where both hypertension and hypertriglyceridemia exist, cilnidipine can be a promising drug of choice.
authors.affiliation: Department of Cardiology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, India.
authors.forename: Prakash
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Das
authors.affiliation: Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, India.
authors.forename: Satish
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, India.
authors.forename: Manju
authors.initials: M
authors.lastname: Gari
authors.affiliation: Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, India.
authors.forename: U S P
authors.initials: US
authors.lastname: Keshri
authors.affiliation: Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, India.
authors.forename: Kusum
authors.initials: K
authors.lastname: Kumari
keywords: Cilnidipine; Dyslipidemia; Heart rate; Hypertension; Hypertriglyceridemia; L- and N-type calcium channel blocker