title: Topography-Guided PRK and Crosslinking in Eyes with Keratoconus and Post-LASIK Ectasia.
abstract: Topography-guided photorefractive keratectomy (TG-PRK) combined with corneal collagen crosslinking (CXL) has been shown to potentially improve vision and stabilize progression in patients with keratoconus (KC). We attempted to reproduce the previously published results using a different laser platform (AMARIS 500E) in patients with KC and post-LASIK ectasia (PLE). All of the 9 included eyes showed improved topography (Kmax, Kmean, RMS HOA, vertical coma, cylinder; p < 0.05) and improved visual acuity (BCVA, UCVA; p < 0.05) after 18 months. Despite some still uncontrollable factors, the combination of TG-PRK and CXL may be a promising option to regularize and stabilize corneas with KC and PLE and improve visual acuity.
authors.affiliation: Vista Klinik, Binningen, Switzerland.
authors.forename: T M
authors.initials: TM
authors.lastname: Müller
authors.affiliation: Vista Klinik, Binningen, Switzerland.
authors.forename: A P
authors.initials: AP
authors.lastname: Lange
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy / Q000379:methods; D019781:Corneal Topography / Q000379:methods*; D003432:Cross-Linking Reagents / Q000627:therapeutic use; D004108:Dilatation, Pathologic / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis / Q000628:therapy*; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods; D018903:Photorefractive Keratectomy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012256:Riboflavin / Q000627:therapeutic use*; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D012256:Riboflavin