title: Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms.
abstract: To overcome the recent outbreaks of hepatotoxicity-related drugs, a new analytical tool for the continuously determination of these drugs in human fluids is required. Electrochemical-based analytical methods offer an effective, rapid, and simple tool for on-site determination of various organic and inorganic species. However, the design of a sensitive, selective, stable, and reproducible sensor is still a major challenge. In the present manuscript, a facile, one-pot hydrothermal synthesis of bismuth oxide (Bi2O2.33) nanostructures (nanorods) was developed. These BiO nanorods were cast onto mass disposable graphite screen-printed electrodes (BiO-SPEs), allowing the ultrasensitive determination of acetaminophen (APAP) in the presence of its common interference isoniazid (INH), which are both found in drug samples. The simultaneous electroanalytical sensing using BiO-SPEs exhibited strong electrocatalytic activity toward the sensing of APAP and INH with an enhanced analytical signal (voltammetric peak) over that achievable at unmodified (bare) SPEs. The electroanalytical sensing of APAP and INH are possible with accessible linear ranges from 0.5 to 1250 μM and 5 to 1760 μM with limits of detection (3σ) of 30 nM and 1.85 μM, respectively. The stability, reproducibility, and repeatability of BiO-SPE were also investigated. The BiO-SPEs were evaluated toward the sensing of APAP and INH in human serum, urine, saliva, and tablet samples. The results presented in this paper demonstrate that BiO-SPEs sensing platforms provide a potential candidate for the accurate determination of APAP and INH within human fluids and pharmaceutical formulations.
authors.affiliation: Chemistry Department, Faculty of Science, Sohag University , 82524 Sohag, Egypt.
authors.forename: Bahaa G
authors.initials: BG
authors.lastname: Mahmoud
authors.affiliation: Chemistry Department, Faculty of Science, Sohag University , 82524 Sohag, Egypt.
authors.forename: Mohamed
authors.identifier: 0000-0002-8579-0093
authors.initials: M
authors.lastname: Khairy
authors.affiliation: Chemistry Department, Faculty of Science, Sohag University , 82524 Sohag, Egypt.
authors.forename: Farouk A
authors.initials: FA
authors.lastname: Rashwan
authors.affiliation: Faculty of Science and Engineering, Manchester Metropolitan University , Chester Street, Manchester M1 5GD, United Kingdom.
authors.forename: Craig E
authors.initials: CE
authors.lastname: Banks
mesh_terms: D000082:Acetaminophen / Q000378:metabolism* / Q000633:toxicity; D018712:Analgesics, Non-Narcotic / Q000378:metabolism* / Q000633:toxicity; D000995:Antitubercular Agents / Q000378:metabolism* / Q000633:toxicity; D001729:Bismuth / Q000737:chemistry*; D001826:Body Fluids / Q000378:metabolism; D002384:Catalysis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D006801:Humans; D007538:Isoniazid / Q000378:metabolism* / Q000633:toxicity; D057230:Limit of Detection; D008099:Liver / Q000187:drug effects*; D043942:Nanotubes / Q000737:chemistry*; D015203:Reproducibility of Results
chemical_list: D018712:Analgesics, Non-Narcotic; D000995:Antitubercular Agents; D000082:Acetaminophen; C033301:bismuth oxide; D001729:Bismuth; D007538:Isoniazid