title: Advances in the clinical translation of nanotechnology.
abstract: The use of novel materials in the nano-scale size range for applications in devices, drugs and diagnostic agents comes with a number of new opportunities, and also serious challenges to human applications. The larger size of particulate-based agents, as compared to traditional drugs, allows for the significant advantages of multivalency and multi-functionality. However, the human use of nanomaterials requires a thorough understanding of the biocompatibility of the synthetic molecules and their complex pharmacology. Possible toxicities created by the unusual properties of the nanoparticles are neither well-understood, nor predictable yet. A key to the successful use of the burgeoning field of nanomaterials as diagnostic and therapeutic agents will be to appropriately match the biophysical features of the particle to the disease system to be evaluated or treated.
authors.affiliation: Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: scheinbd@mskcc.org.
authors.forename: David A
authors.initials: DA
authors.lastname: Scheinberg
authors.affiliation: Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Grimm
authors.affiliation: Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Heller
authors.affiliation: Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Evan P
authors.initials: EP
authors.lastname: Stater
authors.affiliation: Radiology Department, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Bradbury
authors.affiliation: Radiology Department, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: McDevitt
mesh_terms: D003952:Diagnostic Imaging; D015316:Genetic Therapy; D006801:Humans; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000639:trends*; D009369:Neoplasms / Q000628:therapy; D057170:Translational Research, Biomedical / Q000639:trends*