title: The SUMO Pathway in Mitosis.
abstract: Mitosis is the stage of the cell cycle during which replicated chromosomes must be precisely divided to allow the formation of two daughter cells possessing equal genetic material. Much of the careful spatial and temporal organization of mitosis is maintained through post-translational modifications, such as phosphorylation and ubiquitination, of key cellular proteins. Here, we will review evidence that sumoylation, conjugation to the SUMO family of small ubiquitin-like modifiers, also serves essential regulatory roles during mitosis. We will discuss the basic biology of sumoylation, how the SUMO pathway has been implicated in particular mitotic functions, including chromosome condensation, centromere/kinetochore organization and cytokinesis, and what cellular proteins may be the targets underlying these phenomena.
authors.affiliation: Section on Cell Cycle Regulation, Laboratory of Gene Regulation and Development, National Institute of Child Health and Development, National Institutes of Health, 18 Library Drive, Room 106, Building 18T, Bethesda, MD, 20892, USA.
authors.forename: Debaditya
authors.initials: D
authors.lastname: Mukhopadhyay
authors.affiliation: Section on Cell Cycle Regulation, Laboratory of Gene Regulation and Development, National Institute of Child Health and Development, National Institutes of Health, 18 Library Drive, Room 106, Building 18T, Bethesda, MD, 20892, USA. mdasso@helix.nih.gov.
authors.forename: Mary
authors.initials: M
authors.lastname: Dasso
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D048749:Cytokinesis; D006801:Humans; D008938:Mitosis; D009690:Nucleic Acid Conformation; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D058207:Sumoylation; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; D044767:Ubiquitin-Protein Ligases
keywords: Condensin; Kinetochore; Mitosis; SUMO; Topoisomerase