title: Study of poly-ɛ-caprolactone membranes for pleurodesis.
abstract: OBJECTIVE
  Pleurodesis with biomaterial membrane is an emerging treatment method for pneumothorax. However, the ideal one for the common disease is still under debate.
  
  
  METHODS
  We investigate the Poly-ε-caprolactone (PCL) membrane pleurodesis by using New Zealand White rabbits, which was sacrificed for examination one month later. Moreover, inflammation and fibrosis scoring were done under microscopic evaluation, as well as Western blot analysis in vitro and in vivo.
  
  
  RESULTS
  Gross evaluation of pleurodesis score revealed that dense PCL membrane produced moderate pleural adhesion, while porous PCL membrane exhibited significantly higher pleurodesis scores.
  
  
  CONCLUSIONS
  PCL membrane induced significant degree of adhesion, both within the abdomen and chest of the rabbits. The porous PCL membrane produces more intensive adhesion than dense one. Fibronectin plays an important role in the process of pleurodesis. Further study is required for the clinical application of the promising material.
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Ke-Cheng
authors.initials: KC
authors.lastname: Chen
authors.affiliation: Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Min-Shu
authors.initials: MS
authors.lastname: Hsieh
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
authors.forename: Yun-Ru
authors.initials: YR
authors.lastname: Li
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
authors.forename: Yong-Chong
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Hong-Shiee
authors.initials: HS
authors.lastname: Lai
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Ming-Jium
authors.initials: MJ
authors.lastname: Shieh
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chenjs@ntu.edu.tw.
authors.forename: Jin-Shing
authors.initials: JS
authors.lastname: Chen
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan. Electronic address: thyoung@ntu.edu.tw.
authors.forename: Tai-Horng
authors.initials: TH
authors.lastname: Young
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D051379:Mice; D008810:Mice, Inbred C57BL; D018700:Pleurodesis / Q000379:methods*; D011030:Pneumothorax / Q000628:therapy; D011091:Polyesters / Q000008:administration & dosage*; D011817:Rabbits
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; C016240:polycaprolactone
keywords: adhesion; fibronectin; pleurodesis; poly-ɛ-caprolactone membrane; spontaneous pneumothorax