title: The role of 5-HT2creceptor on corticosterone-mediated food intake.
abstract: Corticosterone plays an important role in feeding behavior. However, its mechanism remains unclear. Therefore, the present study aimed to investigate the effect of corticosterone on feeding behavior. In this study, cumulative food intake was increased by acute corticosterone administration in a dose-dependent manner. Administration of the 5-HT2creceptor agonist m-chlorophenylpiperazin (mCPP) reversed the effect of corticosterone on food intake. The anorectic effects of mCPP were also blocked by the 5-HT2creceptor antagonist RS102221 in corticosterone-treated mice. Both corticosterone and mCPP increased c-Fos expression in hypothalamic nuclei, but not the nucleus of the solitary tract. RS102221 inhibited c-Fos expression induced by mCPP, but not corticosterone. In addition, mCPP had little effect on TH and POMC levels in the hypothalamus. Furthermore, mCPP antagonized decreasing effect of the leptin produced by corticosterone. Taken together, our findings suggest that 5-HT2creceptors and leptin may be involved in the effects of corticosterone-induced hyperphagia.
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Ge
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital of Jilin University 126 Xiantai Street, Nanguan District, Changchun, 13033, People's Republic of China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital of Jilin University 126 Xiantai Street, Nanguan District, Changchun, 13033, People's Republic of China.
authors.forename: Jiayin
authors.initials: J
authors.lastname: Lv
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.
authors.forename: Yunong
authors.initials: Y
authors.lastname: Song
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fan
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, USA.
authors.forename: F Scott
authors.initials: FS
authors.lastname: Hall
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.
authors.forename: Bingjin
authors.initials: B
authors.lastname: Li
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.
authors.forename: Ranji
authors.initials: R
authors.lastname: Cui
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000737:chemistry / Q000494:pharmacology; D001069:Appetite Regulation / Q000187:drug effects*; D019167:Appetite Stimulants / Q000008:administration & dosage / Q000819:agonists / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003345:Corticosterone / Q000008:administration & dosage / Q000819:agonists / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D006963:Hyperphagia / Q000097:blood / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D020738:Leptin / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D008813:Mice, Inbred ICR; D009419:Nerve Tissue Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009928:Organ Specificity; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D044405:Receptor, Serotonin, 5-HT2C / Q000737:chemistry / Q000378:metabolism*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology; D013141:Spiro Compounds / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D015854:Up-Regulation / Q000187:drug effects
chemical_list: C000599853:5-hydroxytryptamine2C receptor, mouse; C107821:8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione; D001067:Appetite Depressants; D019167:Appetite Stimulants; D020738:Leptin; D009419:Nerve Tissue Proteins; D010879:Piperazines; D016760:Proto-Oncogene Proteins c-fos; D044405:Receptor, Serotonin, 5-HT2C; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D013141:Spiro Compounds; D013449:Sulfonamides; C015068:1-(3-chlorophenyl)piperazine; D003345:Corticosterone
keywords: 5-HT; c-fos; corticosterone; feeding behavior; receptor