title: Repeated Diffuse Alveolar Hemorrhage in a Patient with Hemophilia B.
abstract: Diffuse alveolar hemorrhage (DAH) is a life-threatening complication that occurs in association with various diseases including coagulation disorders. In rare cases, it is caused by hemophilia. A 48-year-old man was admitted to our hospital for a third time due to DAH. Although the cause of DAH could not be identified by bronchoscopy or laboratory tests, a good response to corticosteroids suggested idiopathic DAH with pulmonary capillaritis. The patient was diagnosed with hemophilia B based on the results of a detailed inquiry, a mildly prolonged activated partial thromboplastin time, and low factor IX activity. Hemophilia may be an underlying factor that exacerbates the bleeding of patients with DAH, even when they show a good response to corticosteroids.
authors.affiliation: Department of Respirology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Kasai
authors.forename: Jiro
authors.initials: J
authors.lastname: Terada
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Hoshi
authors.forename: Takashi
authors.initials: T
authors.lastname: Urushibara
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Kato
authors.forename: Rintaro
authors.initials: R
authors.lastname: Nishimura
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
mesh_terms: D001999:Bronchoscopy; D005938:Glucocorticoids / Q000627:therapeutic use; D002836:Hemophilia B / Q000150:complications* / Q000175:diagnosis; D006470:Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids