title: Direct and rapid effects of 3,5-diiodo-L-thyronine (T2).
abstract: A growing number of researchers are focusing their attention on the possibility that thyroid hormone metabolites, particularly 3,5-diiodothyronine (T2), may actively regulate energy metabolism at the cellular, rather than the nuclear, level. Due to their biochemical features, mitochondria have been the focus of research on the thermogenic effects of thyroid hormones. Indeed, mitochondrial activities have been shown to be regulated both directly and indirectly by T2-specific pathways. Herein, we describe the effects of T2 on energy metabolism.
authors.affiliation: Department of Science and Technologies, University of Sannio, Benevento, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Moreno
authors.affiliation: Department of Science and Technologies, University of Sannio, Benevento, Italy.
authors.forename: Antonia
authors.initials: A
authors.lastname: Giacco
authors.affiliation: Department of Science and Technologies, University of Sannio, Benevento, Italy.
authors.forename: Celia
authors.initials: C
authors.lastname: Di Munno
authors.affiliation: Department of Science and Technologies, University of Sannio, Benevento, Italy. Electronic address: goglia@unisannio.it.
authors.forename: Fernando
authors.initials: F
authors.lastname: Goglia
mesh_terms: D000818:Animals; D004104:Diiodothyronines / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways; D008928:Mitochondria / Q000378:metabolism*; D022722:Thermogenesis
chemical_list: D004104:Diiodothyronines; C030103:3,5-diiodothyronine
keywords: 3,5-Diiodothyronine; Energy metabolism; Metabolic rate; Mitochondria; Short-term effects; Thyroid hormone action