title: Synthesis of gem-Difluorinated Hydroxypyrrolidines.
abstract: A method for the synthesis of 3-hydroxy-4,4-difluoropyrrolidines from α,α-difluoro-β-bromoketones is described. The reaction involves methylenation of the carbonyl group with tetrahydrothiophenium ylide followed by coupling with primary amines.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry , 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Fedorov
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry , 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors.forename: Marina I
authors.initials: MI
authors.lastname: Struchkova
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry , 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors.forename: Alexander D
authors.identifier: 0000-0001-8048-7223
authors.initials: AD
authors.lastname: Dilman