title: Cranberry capsules to prevent nosocomial urinary tract bacteriuria after pelvic surgery: a randomised controlled trial.
abstract: OBJECTIVE
  To evaluate whether cranberries are able to prevent postoperative urinary bacteriuria in patients undergoing pelvic surgery and receiving transurethral catheterisation.
  
  
  METHODS
  Randomised, double-blind, placebo-controlled trial.
  
  
  METHODS
  French tertiary Care centre, University Hospital.
  
  
  METHODS
  A total of 272 women undergoing pelvic surgery aged 18 or older.
  
  
  METHODS
  Participants undergoing pelvic surgery were randomised to 36 mg cranberry (proanthocyanidins, PAC) or placebo once daily for 10 days. Statistical analysis was performed by a chi-square test.
  
  
  METHODS
  The primary and secondary outcomes were postoperative bacteriuria, defined by a positive urine culture, within the first 15 and 40 days, respectively.
  
  
  RESULTS
  Two hundred and fifty-five participants received the intended treatment: 132 (51.8%) received PAC and 123 (48.2%) received placebo. There were no significant differences in baseline demographics, intra-operative characteristics or duration and type of catheterisation between the two groups. PAC prophylaxis did not reduce the risk of bacteriuria treatment within 15 days of surgery [27% bacteriuria with PAC compared with 25% bacteriuria with placebo: relative risk 1.05, 95% CI 0.78-1.4, P = 0.763). The same result was observed on day 40. Bacteriuria occurred more often in older women with increased length of catheterisation.
  
  
  CONCLUSIONS
  Immediate postoperative prophylaxis with PAC does not reduce the risk of postoperative bacteriuria in patients receiving short-term transurethral catheterisation after pelvic surgery.
  
  
  CONCLUSIONS
  PAC prophylaxis does not reduce the risk of postoperative bacteriuria in patients undergoing pelvic surgery.
authors.affiliation: Department of Obstetrics and Gynaecology, Nimes University Hospital, Nîmes, France.
authors.forename: V
authors.initials: V
authors.lastname: Letouzey
authors.affiliation: Department of Obstetrics and Gynaecology, Nimes University Hospital, Nîmes, France.
authors.forename: D
authors.initials: D
authors.lastname: Ulrich
authors.affiliation: Department of Biostatistics, Epidemiology, Public Health and Bio-informatics, Nîmes University Hospital, Nîmes, France.
authors.forename: C
authors.initials: C
authors.lastname: Demattei
authors.affiliation: Department of Biostatistics, Epidemiology, Public Health and Bio-informatics, Nîmes University Hospital, Nîmes, France.
authors.forename: S
authors.initials: S
authors.lastname: Alonso
authors.affiliation: Department of Obstetrics and Gynaecology, Nimes University Hospital, Nîmes, France.
authors.forename: S
authors.initials: S
authors.lastname: Huberlant
authors.affiliation: Department of Microbiology, Nîmes University Hospital, Nîmes, France.|National Institute of Health and Medical Research, U1047, University of Montpellier, Nîmes, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Lavigne
authors.affiliation: Department of Obstetrics and Gynaecology, Nimes University Hospital, Nîmes, France.
authors.forename: R
authors.initials: R
authors.lastname: de Tayrac
mesh_terms: D000328:Adult; D001437:Bacteriuria / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002214:Capsules; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010388:Pelvis / Q000601:surgery*; D008517:Phytotherapy / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014546:Urinary Catheterization / Q000009:adverse effects*; D029799:Vaccinium macrocarpon
chemical_list: D002214:Capsules
keywords: Bacteriuria; catheterisation; cranberry capsules; pelvic surgery; urinary tract infections