title: Exploring the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme patients by a novel survival analysis model.
abstract: This study is to explore the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme (GBM) patients.
  
  
  
  Our results not only showed that mutually explored GBM survival time related genes and signaling transduction pathways are closely related to the GBM, but also demonstrated that our innovated constrained optimization algorithm (CoxSisLasso strategy) are better than the classical methods (CoxLasso and CoxSis strategy).
  
  
  
  We analyzed why the CoxSisLasso strategy can outperform the existing classical methods and discuss how to extend this research in the distant future.
authors.affiliation: College of Computer and Information Science, Southwest University, Chongqing, 400715, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Systems Biology, the University of Texas MD Anderson Cancer Center, Houston, USA.|Breast Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: Chuanwei
authors.initials: C
authors.lastname: Yang
authors.affiliation: Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.affiliation: Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, People's Republic of China.
authors.forename: Zhenzhou
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Chongqing Zhongdi Medical Information Technology Co., Ltd, Chongqing, 401320, People's Republic of China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: He
authors.affiliation: College of Mathematics and Statistics, Southwest University, Chongqing, 400715, People's Republic of China. tinalee@swu.edu.cn.
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.affiliation: College of Computer and Information Science, Southwest University, Chongqing, 400715, People's Republic of China. zhanglcq@swu.edu.cn.|College of Mathematics and Statistics, Southwest University, Chongqing, 400715, People's Republic of China. zhanglcq@swu.edu.cn.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies; D005909:Glioblastoma / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality*; D006801:Humans; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D015398:Signal Transduction; D016019:Survival Analysis; D057188:Workflow
keywords: Cox proportional hazards model (Cox); Glioblastoma multiforme (GBM); Least absolute shrinkage and selection operator (Lasso); Signaling transduction pathway; Sure independence screening (SIS)