title: Validation of a quantitative method to measure neural respiratory drive in children during sleep.
abstract: Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep.
  
  
  
  Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-investigator reproducibility. Effects of different band pass filter settings (20-100Hz vs 10-1000Hz) on sEMGdi amplitude were evaluated.
  
  
  
  Mean sEMGdi from 45 children aged 4.38 years (median; IQR 3.00-7.96) was 5.05μV (SD 2.73). The sEMGdi had a high intra-subject intraclass correlation coefficient (ICC) of 0.88. sEMGdi analysis was reproducible with high ICC between occasions (0.99; 95% CI 0.98-0.99) and between investigators (0.98; 95% CI 0.97-0.99). There was also a high ICC (0.99, 95% CI 0.96-1.00) between the sEMGdi measured using different band-pass filter settings. Age and BMI were negative predictors of sEMGdi (p<0.0001 and p=0.0004 respectively).
  
  
  
  NRD in children during sleep as assessed by sEMGdi can be quantified in a reliable and reproducible fashion.
authors.affiliation: Respiratory Department, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia; School of Women's and Children's Health, University of New South Wales, Level 8, The Bright Alliance Building, Cnr of Avoca & High Streets, Randwick, NSW 2031, Australia. Electronic address: sandra.chuang@unsw.edu.au.
authors.forename: Sandra Ya-Chu
authors.initials: SY
authors.lastname: Chuang
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Level 8, The Bright Alliance Building, Cnr of Avoca & High Streets, Randwick, NSW 2031, Australia; Sleep Medicine Department, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.
authors.forename: Arthur
authors.initials: A
authors.lastname: Teng
authors.affiliation: Neuroscience Research Australia, Barker St, Randwick, NSW 2031, Australia; School of Medical Sciences, Wallace Wurth Building, University of New South Wales, Kensington, NSW 2052, Australia.
authors.forename: Jane Elizabeth
authors.initials: JE
authors.lastname: Butler
authors.affiliation: Neuroscience Research Australia, Barker St, Randwick, NSW 2031, Australia; School of Medical Sciences, Wallace Wurth Building, University of New South Wales, Kensington, NSW 2052, Australia.
authors.forename: Simon Charles
authors.initials: SC
authors.lastname: Gandevia
authors.affiliation: Respiratory Department, Children's Hospital Westmead, Corner Hawkesbury Road and Hainsworth Street, Westmead, NSW 2145, Australia.
authors.forename: Hiran
authors.initials: H
authors.lastname: Selvadurai
authors.affiliation: Respiratory Department, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia; School of Women's and Children's Health, University of New South Wales, Level 8, The Bright Alliance Building, Cnr of Avoca & High Streets, Randwick, NSW 2031, Australia.
authors.forename: Adam
authors.initials: A
authors.lastname: Jaffe
mesh_terms: D002648:Child; D002675:Child, Preschool; D003964:Diaphragm / Q000502:physiology*; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D015203:Reproducibility of Results; D012119:Respiration; D012890:Sleep / Q000502:physiology*
keywords: Child; Diaphragm EMG; Physiology; Polysomnography; Reproducibility; Sleep