title: [Effect of hypoxia on expression of multidrug resistance protein 2 and its regulation mechanism].
abstract: Drug efflux transporters plays a key role in pharmacokinetics parameters changes. In recent years, in addition to P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), MRP2 has become an advanced research hotspot. Several signaling pathways andtranscription factors have been reported to be involved in regulation of MRP2 expression in hypoxic microenvironment of tumor, such as peroxisome proliferators-activated receptors (PPARα), nuclear factor κB (NF-κB), pregnane X receptor (PXR), farnesoid X receptor (FXR), constitutive androstane receptor (CAR) and microRNA. But it is not fully understood how MRP2 is regulated under hypoxia. MRP2 is one of the most important efflux transporter proteins. Many drugs or inhibitors have been shown to be its substrate. In the hypoxic environment, changes in expression of MRP2 can significantly affect drug's pharmacokinetics (absorption, distribution, metabolism, excretion). Simultaneously, the regulation of MRP2 expression under hypoxic might involve several signal pathways and many genes, which constitute an integral gene regulatory networks.
authors.affiliation: School of Pharmacy, Lanzhou University, Lanzhou 730000;. PLA Key Laboratory of the Plateau of the  Environmental Damage Control, Lanzhou General Hospital, Lanzhou Command, Lanzhou 730050, China.
authors.forename: Bingfeng
authors.initials: B
authors.lastname: Luo
authors.affiliation: PLA Key Laboratory of the Plateau of the  Environmental Damage Control, Lanzhou General Hospital, Lanzhou Command, Lanzhou 730050, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Li
authors.affiliation: School of Pharmacy, Lanzhou University, Lanzhou 730000;. PLA Key Laboratory of the Plateau of the  Environmental Damage Control, Lanzhou General Hospital, Lanzhou Command, Lanzhou 730050, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.affiliation: PLA Key Laboratory of the Plateau of the  Environmental Damage Control, Lanzhou General Hospital, Lanzhou Command, Lanzhou 730050, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Pharmacy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou 730050, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Lanzhou University, Lanzhou 730000;. PLA Key Laboratory of the Plateau of the  Environmental Damage Control, Lanzhou General Hospital, Lanzhou Command, Lanzhou 730050, China.
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Jia
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D000090702:Constitutive Androstane Receptor; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D053263:Gene Regulatory Networks / Q000235:genetics / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000235:genetics* / Q000503:physiopathology*; D026901:Membrane Transport Proteins; D035683:MicroRNAs / Q000235:genetics; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D016328:NF-kappa B / Q000235:genetics; D047493:PPAR alpha / Q000235:genetics; D010599:Pharmacokinetics; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D011987:Receptors, Steroid / Q000235:genetics; D015398:Signal Transduction; D059016:Tumor Microenvironment / Q000235:genetics* / Q000502:physiology*; D000097202:ATP-Binding Cassette Sub-Family B Member 4
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D000090702:Constitutive Androstane Receptor; D026901:Membrane Transport Proteins; D035683:MicroRNAs; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D016328:NF-kappa B; D047493:PPAR alpha; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D000097202:ATP-Binding Cassette Sub-Family B Member 4