title: The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH.
abstract: Edible seaweeds have been consumed by Asian coastal communities since ancient times.Fucus vesiculosusandAscophyllum nodosumextracts have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We evaluated the ability of extracts obtained from these algae to inhibit the digestive enzymes α-amylase and α-glucosidase in vitro, and control postprandial plasma glucose levels in a mouse model of non-alcoholic steatohepatitis (NASH); a liver disease often preceding the development of Type 2 diabetes (T2DM). This model was obtained by the administration of a high-fat diet. Our results demonstrate that these algae only delayed and reduced the peak of blood glucose (p< 0.05) in mice fed with normal diet, without changing the area under the blood glucose curve (AUC). In the model of NASH, the phytocomplex was able to reduce both the postprandial glycaemic peak, and the AUC. The administration of the extract in a diet particularly rich in fat is associated with a delay in carbohydrate digestion, but also with a decrease in its assimilation. In conclusion, our results indicate that this algal extract may be useful in the control of carbohydrate digestion and absorption. This effect may be therapeutically exploited to prevent the transition of NASH to T2DM.
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. daniela.gabbia@gmail.com.
authors.forename: Daniela
authors.initials: D
authors.lastname: Gabbia
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. stefano.dallacqua@unipd.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Dall'Acqua
authors.affiliation: Department of Chemical Sciences, University of Padova, 35131 Padova, Italy. iolemaria.digangi@unipd.it.
authors.forename: Iole Maria
authors.initials: IM
authors.lastname: Di Gangi
authors.affiliation: Department of Chemical Sciences, University of Padova, 35131 Padova, Italy. sara.bogialli@unipd.it.
authors.forename: Sara
authors.initials: S
authors.lastname: Bogialli
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. valekap@gmail.com.
authors.forename: Valentina
authors.initials: V
authors.lastname: Caputi
authors.affiliation: Department of Medicine, General Pathology and Cytopathology Unit, University of Padova, 35128 Padova, Italy. aoichan@libero.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Albertoni
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. ilaria.marsilio@gmail.com.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Marsilio
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. nicolapaccagnella89@gmail.com.
authors.forename: Nicola
authors.initials: N
authors.lastname: Paccagnella
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. maria.carrara@unipd.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Carrara
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. ceci.giron@gmail.com.
authors.forename: Maria Cecilia
authors.initials: MC
authors.lastname: Giron
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. sara.demartin@unipd.it.
authors.forename: Sara
authors.initials: S
authors.lastname: De Martin
mesh_terms: D000818:Animals; D044646:Ascophyllum / Q000737:chemistry*; D001786:Blood Glucose / Q000187:drug effects*; D050260:Carbohydrate Metabolism / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control*; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D044645:Fucus / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D012624:Seaweed / Q000737:chemistry; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D000516:alpha-Amylases; D000520:alpha-Glucosidases
keywords: Ascophyllum nodosum; Fucus vesiculosus; nonalcoholic steatohepatitis; postprandial blood glucose level