title: Fibroblast Growth Factors in the Gastrointestinal Tract: Twists and Turns.
abstract: Fibroblast growth factors (FGFs) are a family of conserved peptides that play an important role in the development, homeostasis, and repair processes of many organ systems, including the gastrointestinal tract. All four FGF receptors and several FGF ligands are present in the intestine. They play important roles in controlling cell proliferation, differentiation, epithelial cell restitution, and stem cell maintenance. Several FGFs have also been proven to be protective against gastrointestinal diseases such as inflammatory bowel diseases or to aid in regeneration after intestinal loss associated with short bowel syndrome. Herein, we review the multifaceted actions of canonical FGFs in intestinal development, homeostasis, and repair in rodents and humans. Developmental Dynamics 246:344-352, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Developmental Biology and Regenerative Medicine Program, Department of Pediatric Surgery, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA.|Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Soula
authors.initials: S
authors.lastname: Danopoulos
authors.affiliation: Developmental Biology and Regenerative Medicine Program, Department of Pediatric Surgery, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA.|Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Schlieve
authors.affiliation: Developmental Biology and Regenerative Medicine Program, Department of Pediatric Surgery, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA.|Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Tracy C
authors.initials: TC
authors.lastname: Grikscheit
authors.affiliation: Developmental Biology and Regenerative Medicine Program, Department of Pediatric Surgery, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA.|Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Denise
authors.identifier: 0000-0003-3148-7352
authors.initials: D
authors.lastname: Al Alam
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors / Q000502:physiology*; D005767:Gastrointestinal Diseases / Q000378:metabolism / Q000517:prevention & control; D041981:Gastrointestinal Tract / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000254:growth & development; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D012038:Regeneration; D012377:Rodentia
chemical_list: D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors
keywords: FGF; development; homeostasis; intestine; repair