title: Mutant p53-Nrf2 axis regulates the proteasome machinery in cancer.
abstract: The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors. In triple negative breast cancer cells this resistance mechanism, namely the Nrf2-regulated "bounce-back" response to proteasome inhibitors, can be overcome by targeting p53 mutant proteins with APR-246/PRIMA-1Met.
authors.affiliation: Laboratorio Nazionale CIB, Area Science Park Padriciano , Trieste, Italy.
authors.forename: Kamil
authors.initials: K
authors.lastname: Lisek
authors.affiliation: Laboratorio Nazionale CIB, Area Science Park Padriciano , Trieste, Italy.
authors.forename: Dawid
authors.initials: D
authors.lastname: Walerych
authors.affiliation: Laboratorio Nazionale CIB, Area Science Park Padriciano, Trieste, Italy; Dipartimento di Scienze della Vita-Università degli Studi di Trieste, Trieste, Italy.
authors.forename: Giannino
authors.initials: G
authors.lastname: Del Sal
keywords: APR-246; Chip-seq; Keap1; Nrf2; TNBC; cancer; multi-omics; mutant p53; proteasome; proteomics; transcriptomics