title: Enhancing NMR of Nonrelaxing Species Using a Controlled Flow Motion and a Miniaturized Circuit.
abstract: In this article we show that circulation of the sample in a closed-loop circuit combined to microsized detection can lead to a significant signal NMR enhancement. We present an optimized NMR device based on a mini bubble-pump associated with fluidics and microdetection that can be installed on a commercial NMR spectrometer. In addition to a significant signal enhancement for slowly relaxing nuclei, we show that it enables more precise and frequent monitoring of chemical reactions. An additional modification leads to a stopped-flow system very efficient for instance for 2D NMR experiments with long mixing times.
authors.affiliation: NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette, France.
authors.forename: Guillaume
authors.identifier: 0000-0002-2083-3654
authors.initials: G
authors.lastname: Carret
authors.affiliation: NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Berthelot
authors.affiliation: NIMBE, CEA, CNRS, Université Paris-Saclay , CEA Saclay, 91191 Gif-sur-Yvette, France.
authors.forename: Patrick
authors.identifier: 0000-0003-4008-2912
authors.initials: P
authors.lastname: Berthault