title: Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases.
abstract: Cytoplasmic stress granules (SGs) are critical for facilitating stress responses and for preventing the accumulation of misfolded proteins. SGs, however, have been linked to the pathogenesis of neurodegenerative diseases, in part because SGs share many components with neuronal granules. Oxidative stress is one of the conditions that induce SG formation. SGs regulate redox levels, and SG formation in turn is differently regulated by various types of oxidative stress. These associations and other evidences suggest that SG formation contributes to the development of neurodegenerative diseases. In this paper, we review the regulation of SG formation/assembly and discuss the interactions between oxidative stress and SG formation. We then discuss the links between SGs and neurodegenerative diseases and the current therapeutic approaches for neurodegenerative diseases that target SGs.
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, P.O. Box 462, Medicinaregatan 9E, S-413 90 Gothenburg, Sweden.
authors.forename: Lihua
authors.identifier: 0000-0002-3598-2855
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, P.O. Box 462, Medicinaregatan 9E, S-413 90 Gothenburg, Sweden.
authors.forename: Beidong
authors.identifier: 0000-0001-6052-8411
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*