title: Antimicrobial Resistance of Escherichia coli Urinary Isolates in the Veterans Affairs Health Care System.
abstract: We reviewed data for almost 300,000 clinicalEscherichia coliurinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Control and Prevention National Healthcare Safety Network definitions or guidance. Rates of resistance to amoxicillin or ampicillin/β-lactamase inhibitors were approximately 40% and rates of resistance to fluoroquinolones and trimethoprim-sulfamethoxazole approached 30%. Rates of resistance to nitrofurantoin, antipseudomonal penicillin/β-lactamase inhibitors, and carbapenems remained less than 10%. The percentage of isolates that were considered multidrug resistant varied (4% to 37%), depending on the definitions used.
authors.affiliation: Veterans Affairs Medical Center, Infectious Diseases Research Program, Providence, Rhode Island, USA haley.morrill@va.gov.|Veterans Affairs Medical Center, Center of Innovation in Long Term Services and Supports, Providence, Rhode Island, USA.|University of Rhode Island, Department of Pharmacy Practice, College of Pharmacy, Kingston, Rhode Island, USA.
authors.forename: Haley J
authors.initials: HJ
authors.lastname: Morrill
authors.affiliation: Veterans Affairs Medical Center, Infectious Diseases Research Program, Providence, Rhode Island, USA.|University of Rhode Island, Department of Pharmacy Practice, College of Pharmacy, Kingston, Rhode Island, USA.
authors.forename: Jacob B
authors.initials: JB
authors.lastname: Morton
authors.affiliation: Veterans Affairs Medical Center, Infectious Diseases Research Program, Providence, Rhode Island, USA.|Veterans Affairs Medical Center, Center of Innovation in Long Term Services and Supports, Providence, Rhode Island, USA.|University of Rhode Island, Department of Pharmacy Practice, College of Pharmacy, Kingston, Rhode Island, USA.
authors.forename: Aisling R
authors.initials: AR
authors.lastname: Caffrey
authors.affiliation: Veterans Affairs Medical Center, Center of Innovation in Long Term Services and Supports, Providence, Rhode Island, USA.
authors.forename: Lan
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Veterans Affairs Medical Center, Center of Innovation in Long Term Services and Supports, Providence, Rhode Island, USA.|Center for Gerontology and Health Care Research, Brown University School of Public Health, Providence, Rhode Island, USA.
authors.forename: David
authors.initials: D
authors.lastname: Dosa
authors.affiliation: Veterans Affairs Medical Center, Center of Innovation in Long Term Services and Supports, Providence, Rhode Island, USA.|Department of Epidemiology and Infection Control, Rhode Island Hospital, Providence, Rhode Island, USA.|Warren Alpert Medical School of Brown University, Department of Medicine, Providence, Rhode Island, USA.
authors.forename: Leonard A
authors.initials: LA
authors.lastname: Mermel
authors.affiliation: Veterans Affairs Medical Center, Infectious Diseases Research Program, Providence, Rhode Island, USA.|Veterans Affairs Medical Center, Center of Innovation in Long Term Services and Supports, Providence, Rhode Island, USA.|University of Rhode Island, Department of Pharmacy Practice, College of Pharmacy, Kingston, Rhode Island, USA.|Warren Alpert Medical School of Brown University, Department of Medicine, Providence, Rhode Island, USA.
authors.forename: Kerry L
authors.initials: KL
authors.lastname: LaPlante
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy*; D024841:Fluoroquinolones / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014481:United States; D014493:United States Department of Veterans Affairs; D014551:Urinary Tract / Q000382:microbiology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D014728:Veterans; D065093:beta-Lactamase Inhibitors / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D065093:beta-Lactamase Inhibitors; D000667:Ampicillin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Escherichia coli; resistance; urinary tract infection