title: Prevalence of human papillomavirus infection among 71,435 women in Jiangxi Province, China.
abstract: Cervical cancer is the third most common cancer in women worldwide. Human papillomavirus (HPV) has been identified as an etiological factor for cervical cancer. Data on the prevalence and subtype distribution of HPV infection in Jiangxi Province are incomplete. In this study, we investigated HPV subtype distribution and prevalence in Jiangxi Province between August 1, 2010, and December 31, 2015. A total of 71,435 individuals ranging in age from 16 to 77 years were recruited. Cervicovaginal swabs were collected from each participant, and HPV screening was performed. Our results showed that the HPV prevalence was 22.49% in Jiangxi Province. Overall, 14.99% of individuals were positive for a single HPV type, and 7.49% were positive for multiple types. The most frequently detected low-risk genotypes were HPV-6, and high-risk genotypes were HPV-16, -18, -33, -52, and -58. The prevalence and type distribution of HPV infection exhibits regional and age differences; Yingtan had the highest incidence for high-risk HPV infection (32.00%), and peaks in the frequencies of HPV infections were seen for patients under 20 and over 60 years of age. In conclusion, we present data showing that the HPV prevalence varies significantly with age and regions in Jiangxi Province. These results can serve as valuable reference to guide Jiangxi cervical cancer screening and HPV vaccination programs.
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, People's Republic of China.
authors.forename: Tian-Yu
authors.initials: TY
authors.lastname: Zhong
authors.affiliation: Department of Surgical Oncology, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People's Republic of China.
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Zhou
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Scientific Research, Gannan Medical University, Ganzhou, Jiangxi 341000, People's Republic of China.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Fan
authors.affiliation: Department of Obstetrics and Gynecology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, People's Republic of China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Xie
authors.affiliation: Department of Obstetrics and Gynecology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, People's Republic of China.
authors.forename: Zhao-Xia
authors.initials: ZX
authors.lastname: Liu
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, Shantou, 515000 Guangdong, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Lin
authors.affiliation: Medical Laboratory, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006, People's Republic of China.
authors.forename: Yi-Guo
authors.initials: YG
authors.lastname: Chen
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, People's Republic of China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Hu
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, People's Republic of China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Department of Medical Laboratory, The Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi 343000, People's Republic of China.
authors.forename: Long
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, People's Republic of China. Electronic address: xiaohuaping00@163.com.
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000821:virology; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology / Q000821:virology; D005260:Female; D005838:Genotype; D052162:Human papillomavirus 16; D052163:Human papillomavirus 6; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D014621:Vagina / Q000821:virology; D055815:Young Adult
keywords: Age; Human papillomavirus; Jiangxi Province; Subtypes