title: Has Vitamin D Had Its "Time In The Sun" For Melanoma?
abstract: Growing evidence suggests a pivotal role for vitamin D in cancers, particularly melanoma. The broad immunologic effects of vitamin D and its signaling axis make for a complex interplay between tumor cells and the immune system. Preclinical evidence suggests vitamin D to have protective effects in melanoma oncogenesis and progression, creating a potential role for vitamin D supplementation in cancer prevention and/or adjuvant therapy. In this commentary, the authors highlight studies of vitamin D in melanoma with clinical implications and call for large clinical trials to definitively determine the role of supplementation in patients to prevent and help treat melanoma.
authors.affiliation: Division of Dermatology and Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Huerter
authors.affiliation: Division of Dermatology and Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska.
authors.forename: Adam
authors.initials: A
authors.lastname: Vaudreuil
authors.affiliation: Division of Dermatology and Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska.
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Agrawal
authors.affiliation: Division of Dermatology and Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska.
authors.forename: Austin Huy
authors.initials: AH
authors.lastname: Nguyen