title: Direct Imaging of Single Plasmonic Metal Nanoparticles in Capillary with Laser Light-Sheet Scattering Imaging.
abstract: Understanding the heterogeneous distribution of the physical and chemical properties of plasmonic metal nanoparticles is fundamentally important to their basic and applied research. Traditionally, they are obtained either indirectly via bulk spectroscopic measurements plus electron microscopic characterizations or through single molecule/particle imaging of nanoparticles immobilized on planar substrates. In this study, by using light-sheet scattering microscopy with a supercontinuum white laser, highly sensitive imaging of individual metal nanoparticles (MNPs) flowing inside a capillary, driven by either pressure or electric field, was achieved for the first time. We demonstrate that single plasmonic nanoparticles with different size or chemical modification could be differentiated through their electrophoretic mobility in a few minutes. This technique could potentially be applied to high throughput characterization and evaluation of single metal nanoparticles as well as their dynamic interactions with various local environments.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University , Changsha, Hunan 410082, P. R. China.|Institute of Pharmacy and Pharmacology, University of South China , Hengyang, Hunan 421001, P. R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing, 100084, P. R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing, 100084, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University , Changsha, Hunan 410082, P. R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University , Changsha, Hunan 410082, P. R. China.|Department of Chemistry, Tsinghua University , Beijing, 100084, P. R. China.
authors.forename: Yan
authors.identifier: 0000-0001-7133-0558
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Chemistry, Iowa State University , Ames, Iowa 50011, United States.
authors.forename: Edward S
authors.initials: ES
authors.lastname: Yeung