title: Characteristics of patients with liver cancer in the BioBank Japan project.
abstract: BACKGROUND
  Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies.
  
  
  METHODS
  Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated.
  
  
  RESULTS
  Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the men was overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively.
  
  
  CONCLUSIONS
  The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.
authors.affiliation: Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Ukawa
authors.affiliation: Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Okada
authors.affiliation: Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Koshi
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirata
authors.affiliation: Department of Public Policy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nagai
authors.affiliation: Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: Department of Health Sciences, University of Yamanashi, Yamanashi, Japan.
authors.forename: Zentaro
authors.initials: Z
authors.lastname: Yamagata
authors.affiliation: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kamatani
authors.affiliation: Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ninomiya
authors.affiliation: Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
authors.affiliation: Department of Public Policy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Muto
authors.affiliation: RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.affiliation: Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Electronic address: tamaa@med.hokudai.ac.jp.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018070:Biological Specimen Banks; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000401:mortality; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015996:Survival Rate
keywords: Cohort; Lifestyle; Liver cancer; Survival rate; Tumor biomarkers