title: [Prognostic value of knowledge of cancer on quality of life in advanced colorectal cancer in clinical practice].
abstract: BACKGROUND
  Colorectal cancer (CRC) is the third most common malignancy and the second cause of cancer deaths worldwide. The development of new drugs in recent years has improved the outcomes, but it still a lot of questions to improve the quality of life of patients receiving palliative care in daily clinical practice. In this study, we evaluated the impact of knowledge of cancer on QOL and the relationship between QOL and various environmental factors in patients with CRC treated with chemotherapy.
  
  
  METHODS
  We analyzed the results of first-line palliative chemotherapy in 165 patients with colorectal cancer treated between May 2010 and December 2014 in two centers. 98 (59%) patients had earlier received postoperative chemotherapy, including 79 with the participation of oxaliplatin. The mean age of patients was 61 ± 8.7 years.
  
  
  RESULTS
  The median survival time was 15 months. In multivariate analysis, significant effect on survival were performance status and response to treatment. There was also a trend toward shorter survival in patients treated with single 5-Fu chemotherapy, in elderly patients and in patients exhibiting a lower knowledge of oncology. We found relationship between overall quality of life and performance status (0 vs> 0), response to treatment and oncological knowledge. The chemotherapy with single chemotherapy 5-Fu was often used in patients over the age of 70 years and in patients with low performance status (p< 0.01).
  
  
  CONCLUSIONS
  The level of knowledge of cancer observed in clinical practice may be related to certain parameters to evaluate the effectiveness of treatment, such as QOL.
authors.affiliation: Poradnia Onkologiczna, Szpital Specjalistyczny im. Floriana Ceynowy, Wejherowo, Polska, e-mail: krzys.adamowicz@gmail.com.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Adamowicz
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D000077150:Oxaliplatin; D010166:Palliative Care; D063046:Patient Medication Knowledge; D011788:Quality of Life
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D005472:Fluorouracil
keywords:  knowledge of cancer ;  quality of life; chemotherapy; colorectal cancer; treatment outcomes