title: Regulation of inflammation by β-arrestins: Not just receptor tales.
abstract: The ubiquitously expressed, multifunctional scaffolding proteins β-arrestin1 and β-arrestin2 each affect inflammatory signaling in a variety of cell lines. In addition to binding the carboxyl-terminal tails of innumerable 7-transmembrane receptors, β-arrestins scaffold untold numbers of other plasma membrane and cytoplasmic proteins. Consequently, the effects of β-arrestins on inflammatory signaling are diverse, and context-specific. This review highlights the roles of β-arrestins in regulating canonical activation of the pro-inflammatory transcription factor NFκB.
authors.affiliation: Department of Medicine (Cardiology), Duke University Medical Center, Durham, North, Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North, Carolina, USA. Electronic address: neil.freedman@duke.edu.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Freedman
authors.affiliation: Department of Medicine (Cardiology), Duke University Medical Center, Durham, North, Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North, Carolina, USA. Electronic address: skshenoy@dm.duke.edu.
authors.forename: Sudha K
authors.initials: SK
authors.lastname: Shenoy
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D014162:Transfection; D054875:Ubiquitination; D000071557:beta-Arrestins / Q000235:genetics / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D000071557:beta-Arrestins
keywords: Arrestins; Inflammation; Ubiquitination