title: Zamamidine D, a Manzamine Alkaloid from an Okinawan Amphimedon sp. Marine Sponge.
abstract: A new manzamine alkaloid, zamamidine D (1), was isolated from an Okinawan Amphimedon sp. marine sponge. The structure of zamamidine D (1) including the relative configuration was elucidated on the basis of spectroscopic data. Zamamidine D (1) is the first manzamine alkaloid possessing a 2,2'-methylenebistryptamine unit as the aromatic moiety instead of a β-carboline unit. Zamamidine D (1) showed antimicrobial activity against several bacteria and fungi.
authors.affiliation: Showa Pharmaceutical University , 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
authors.forename: Takaaki
authors.identifier: 0000-0002-3553-5844
authors.initials: T
authors.lastname: Kubota
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Showa Pharmaceutical University , 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Kurimoto
authors.affiliation: Medical Mycology Research Center, Chiba University , Chiba 260-0856, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Western Australian Museum , Locked Bag 49, Welshpool DC, WA 6986, Australia.
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.affiliation: Medical Mycology Research Center, Chiba University , Chiba 260-0856, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002227:Carbazoles / Q000737:chemistry; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007564:Japan; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002227:Carbazoles; D002243:Carbolines; C000621479:zamamidine D; C078290:manzamine A