title: Preliminary evaluation of altered brain microstructure in the emotion-cognition region in children with haemophilia A: a diffusional kurtosis imaging study.
abstract: OBJECTIVE
  Using diffusional kurtosis imaging (DKI) to assess the impact of emotional disorders on microstructural changes of the brain in children with haemophilia A.
  
  
  METHODS
  Diffusional kurtosis imaging was acquired from haemophilia A (n = 22) and controls (n = 22) using a 3T scanner. A regression analysis of frontal, cingulate, hippocampus, insula and amygdala regions of interest (ROIs) was conducted. Clinical data and results of psychological tests were collected. A paired t-test was used to analyse the differences between the two groups' ROIs, and the Spearman test was used to analyse the correlation between ROIs and psychological tests or clinical data.
  
  
  RESULTS
  Fractional anisotropy (FA) in the left middle cingulate and right hippocampus; mean diffusion (MD) in the frontal lobe, right anterior cingulate and right middle cingulate showed varying degrees of increase in the ROI compared to controls (P < 0.003). MD in the frontal lobe and the course of disease (P < 0.05), FA in the right hippocampus and the social score of the self-consciousness scale (P < 0.01) had a positive correlation.
  
  
  CONCLUSIONS
  Our study is the first to evaluate the relationship between emotion disorders and cognitive changes in the microstructure of the brain in children with haemophilia A, suggesting that DKI provides more information about tissue microstructural changes than do the conventional image method and traditional psychological tests.
authors.affiliation: Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: D
authors.initials: D
authors.lastname: Hu
authors.affiliation: Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Kang
authors.affiliation: Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Hematology Department, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.affiliation: Neurology Department, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Philips Healthcare, Beijing, China.
authors.forename: K
authors.initials: K
authors.lastname: Shi
authors.affiliation: Hematology Department, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: R
authors.initials: R
authors.lastname: Wu
authors.affiliation: Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging*; D003071:Cognition; D004644:Emotions; D006467:Hemophilia A / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male
keywords: children; diffusional kurtosis imaging; emotional disorder; haemophilia A