title: Components of the mitochondrial cAMP signalosome.
abstract: 3'-5'-Cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling is activated by different extracellular stimuli and mediates many diverse processes within the same cell. It is now well established that in order to translate into the appropriate cellular function multiple extracellular inputs, which may act simultaneously on the same cell, the cAMP/PKA signalling pathway is compartmentalised. Multimolecular complexes are organised at specific subcellular sites to generate spatially confined signalosomes, which include effectors, modulators and targets of the pathway. In recent years, it has become evident that mitochondria represent sites of compartmentalised cAMP signalling. However, the exact location and the molecular composition of distinct mitochondria signalosomes and their function remain largely unknown. In this review, we focus on individual components of the cAMP/PKA signalling pathway at distinct mitochondria subdomains represented by the outer and inner mitochondrial membranes, the intermembrane space and the matrix, highlighting some of the questions that remain unanswered.
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K. stefania.monterisi@dpag.ox.ac.uk.
authors.forename: Stefania
authors.initials: S
authors.lastname: Monterisi
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K. stefania.monterisi@dpag.ox.ac.uk.
authors.forename: Manuela
authors.initials: M
authors.lastname: Zaccolo
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; C112770:PDE8A protein, human
keywords: cAMP; cyclic nucleotide phosphodiesterases; intracellular signalling; mitochondria