title: Near-Infrared Light and pH Dual-Responsive Targeted Drug Carrier Based on Core-Crosslinked Polyaniline Nanoparticles for Intracellular Delivery of Cisplatin.
abstract: Biodegradable polymeric nanoparticles have received growing interest as one of the most promising agents for drug delivery. In the present work, functional and core-crosslinked poly(ethylene glycol) with poly(ϵ-caprolactone) (PEG5k-PCL10k) block copolymer and lecithin as biodegradable polymer doped with polyaniline was used to assemble nanoparticles which were prepared for targeted delivery and controlled release of cisplatin. The morphology of the polyaniline nanoparticles was determined by dynamic light scattering and the prepared nanoparticles showed a size of 83(±1) nm and a uniform spherical shape. For targeting to HER2 receptors, Herceptin was applied to guide the nanoparticles to breast cancer cells. Studies on cellular uptake and drug release of the nanocarriers showed that the prepared nanoparticles were efficiently taken up by breast cancer cells and the drug was released efficiently under acidic conditions when exposed to a near-infrared laser (808 nm, 1.54 W) for 5 min. Our research highlights the great potential of near-infrared light and pH dual-responsive release by core-crosslinked nanoparticles in nanobiomedicine.
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Chaoqun
authors.initials: C
authors.lastname: You
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Hongshuai
authors.initials: H
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Minxing
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Yawen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Yanghui
authors.initials: Y
authors.lastname: Luo
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Lihai
authors.initials: L
authors.lastname: Zhai
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210089, P.R. China.
authors.forename: Baiwang
authors.initials: B
authors.lastname: Sun
authors.affiliation: Laboratory of Organic Chemistry, ETH Zürich, 8093, Zürich, Switzerland.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Antibody Technique of Ministry of Health, School of Pathology, Nanjing Medical University, Nanjing, 210093, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D007259:Infrared Rays; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D004337:Drug Carriers; C416807:polyaniline; D011092:Polyethylene Glycols; D002945:Cisplatin
keywords: cisplatin; drug delivery; dual responsive; materials science; photothermal conversion