title: Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?
abstract: BACKGROUND
  Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.
  
  
  METHODS
  Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.
  
  
  RESULTS
  There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02,P= 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09,P= 0.38).
  
  
  CONCLUSIONS
  This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris.
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Iraji
authors.affiliation: Department of Dermatology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Nabet
authors.initials: N
authors.lastname: Tajmirriahi
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Iman
authors.initials: I
authors.lastname: Momeni
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Kioumars
authors.initials: K
authors.lastname: Jamshidi
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Fazlollah
authors.initials: F
authors.lastname: Hashemzehi
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Siadat
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Alireza Asemi
authors.initials: AA
authors.lastname: Esfahani
keywords: Desmoglein; pemphigus vulgaris; prolactin