title: Post-translational modifications of FLOWERING LOCUS C modulate its activity.
abstract: Flowering Locus C (FLC) is a key floral repressor that precisely controls flowering time. The role of FLC has been extensively studied at the transcriptional level using molecular biological and epigenetic approaches. However, how FLC functions and how its stability is controlled at the post-translational level are only beginning to be understood. Recent studies show that various post-translational modifications (PTMs) control the stability and activity of FLC. In this review, we focus on three types of PTMs that regulate FLC function: phosphorylation, ubiquitination, and sumoylation. This report should serve as a model to guide post-translational studies of other important floral regulators.
authors.affiliation: Department of Plant Science and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwak
authors.affiliation: Department of Plant Science and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
authors.forename: Ga Hyun
authors.initials: GH
authors.lastname: Son
authors.affiliation: School of Applied Biosciences, Kyungpook National University, Daegu, Korea.
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Song
authors.affiliation: Department of Plant Science and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea.|Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea.
authors.forename: Hak Soo
authors.initials: HS
authors.lastname: Seo
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D035264:Flowers / Q000254:growth & development* / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D026161:MADS Domain Proteins / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D029681:Arabidopsis Proteins; C418902:At5g10140 protein, Arabidopsis; D026161:MADS Domain Proteins
keywords: FLC; flowering; phosphorylation; post-translational modification; sumoylation; ubiquitination