title: The Lymphatic Circulation in Adaptations to the Fontan Circulation.
abstract: Failing Fontan continues to be major problem for patients on the univentricular pathway. Failing Fontan is often complicated by chylothorax, plastic bronchitis and protein loosing enteropathy. The role of lymphatic circulation in Fontan circulation is still being researched. Newer imaging modalities give insight into the role of abnormal dilatation and retrograde flow in lymphatic channels post Fontan. Interventional strategies targeting abnormal lymphatic channels, provides an alternative management strategy for patients with failing Fontan. This review focuses on the role of lymphatic system in adaptations to Fontan circulation.
authors.affiliation: The Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia.|Sree Chitra Tirunal Institute of Medical sciences and Technology, Thiruvananthapuram, Kerala, 695,011, India.|Sydney Children's Hospital Network, The Children's Hospital at Westmead, 212 Hawkesbury Road, Westmead, NSW, 2145, Australia.
authors.forename: Sabarinath
authors.initials: S
authors.lastname: Menon
authors.affiliation: Sydney Children's Hospital Network, The Children's Hospital at Westmead, 212 Hawkesbury Road, Westmead, NSW, 2145, Australia.|Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Camperdown, NSW, 2006, Australia.
authors.forename: Murthy
authors.initials: M
authors.lastname: Chennapragada
authors.affiliation: The Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia.|Sydney Children's Hospital Network, The Children's Hospital at Westmead, 212 Hawkesbury Road, Westmead, NSW, 2145, Australia.
authors.forename: Shinya
authors.initials: S
authors.lastname: Ugaki
authors.affiliation: The Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia.|Sydney Children's Hospital Network, The Children's Hospital at Westmead, 212 Hawkesbury Road, Westmead, NSW, 2145, Australia.|Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Camperdown, NSW, 2006, Australia.
authors.forename: Gary F
authors.initials: GF
authors.lastname: Sholler
authors.affiliation: The Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia.|Sydney Children's Hospital Network, The Children's Hospital at Westmead, 212 Hawkesbury Road, Westmead, NSW, 2145, Australia.|Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Camperdown, NSW, 2006, Australia.
authors.forename: Julian
authors.initials: J
authors.lastname: Ayer
authors.affiliation: The Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia. david.winlaw@health.nsw.gov.au.|Sydney Children's Hospital Network, The Children's Hospital at Westmead, 212 Hawkesbury Road, Westmead, NSW, 2145, Australia. david.winlaw@health.nsw.gov.au.|Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Camperdown, NSW, 2006, Australia. david.winlaw@health.nsw.gov.au.
authors.forename: David S
authors.initials: DS
authors.lastname: Winlaw
mesh_terms: D000222:Adaptation, Physiological; D001775:Blood Circulation / Q000502:physiology; D001991:Bronchitis / Q000209:etiology; D004108:Dilatation, Pathologic; D018729:Fontan Procedure / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D008208:Lymphatic System / Q000503:physiopathology*; D042601:Lymphatic Vessels / Q000503:physiopathology; D011504:Protein-Losing Enteropathies / Q000209:etiology
keywords: Congenital heart disease; Fontan; Fontan failure; Lymphatic disorders; Lymphatics; Single ventricle physiology