title: Relationship of Plasma Adiponectin and Waist-hip Ratio with Coronary Artery Disease.
abstract: BACKGROUND
  This study aimed to investigate correlation between adiponectin and waist-hip-ratio with severity of coronary artery disease (CAD). There is uncertainty about the association between circulating concentrations of adiponectin and CAD.
  
  
  METHODS
  We enrolled eighty-two consecutive patients undergoing non-urgent coronary angiography for CAD survey. According to the angiography results, the patients were divided into two groups in 1:1 ratio patients admitted with a diagnosis of CAD and non-CAD. We conducted hospital based research, involving study group with documented angiographically CAD, and control group without evidence of CAD. Angiograms were also quantified for the extent and severity of CAD by the Gensini scoring system. We measured baseline adiponectin levels in stored serum samples of all patients, anthropometric and biochemical risk factors were assessed in both groups.
  
  
  RESULTS
  The presence of CAD was associated with current smoking, male gender, waist-hip ratio (WHR) and left ventricular ejection fraction (LVEF). Baseline adiponectin concentrations correlated significantly in terms of the lipid parameters, positively with HDL cholesterol concentrations (r=0.327, P=0.028, P<0.05) and serum triglyceride concentrations were correlated negatively (r=-0.513, P<0.001). No significant difference between median adiponectin levels at baseline was observed between cases and controls.
  
  
  CONCLUSIONS
  There is a significant positive correlation between waist-hip ratio and presence and severity of coronary artery disease. In conclusion, there is a significant positive correlation between adiponectin and Gensini score among Kosovar patients.
authors.affiliation: The Cardiology Clinic, University Clinical Center of Kosovo, Prishtina, Republic of Kosova; Department of Anatomy, University Clinical Center of Kosovo, Prishtina, Republic of Kosova.
authors.forename: Premtim
authors.initials: P
authors.lastname: Rashiti
authors.affiliation: The Cardiology Clinic, University Clinical Center of Kosovo, Prishtina, Republic of Kosova.
authors.forename: Shpend
authors.initials: S
authors.lastname: Elezi
authors.affiliation: Department of Anatomy, University Clinical Center of Kosovo, Prishtina, Republic of Kosova.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Behluli
authors.affiliation: Department of Epidemiology National Institute of Public Health of Kosova.
authors.forename: Sefedin
authors.initials: S
authors.lastname: Mucaj
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects; D013318:Stroke Volume; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: Gensini score; adiponectin; coronary artery disease; waist–hip ratio