title: Survival of people living with HIV who defaulted from tuberculosis treatment in a cohort, Recife, Brazil.
abstract: Tuberculosis is a serious public health problem worldwide. It is the leading cause of death amongst people living with HIV, and default from tuberculosis (TB) treatment in people living with HIV increases the probability of death. The aim of this study was to estimate the survival probability of people living with HIV who default treatment for TB compared to those who complete the treatment.
  
  
  
  This was a longitudinal cohort study of people living with HIV, from June 2007 to December 2013 with two components: a retrospective (for those who started tuberculosis treatment before 2013 for whom failure (death) or censoring occurred before 2013), and prospective (those who started tuberculosis treatment at any time between 2007 and June 2013 and for whom death or censoring occurred after the beginning of 2013), at two referral hospitals for people living with HIV (Correia Picanço Hospital - HCP and at Hospital Universitário Oswaldo Cruz - HUOC), in Recife/PE. A total of 317 patients who initiated TB treatment were studied. Default from TB treatment was defined as any patient who failed to attend their pre-booked return appointment at the health center for more than 30 consecutive days, in accordance with Brazilian Ministry of Health recommendations.
  
  
  
  From a cohort of 2372 people living with HIV we analyzed 317 patients who had initiated TB treatment. The incidence of death was 5.6 deaths per 100 persons per year (CI 95% 4.5 to 7.08). Independent factors associated with death: default from TB treatment 3.65 HR (95% CI 2.28 to 5.83); CD4 < 200 cells/mm32.39 HR (95% CI 1.44 to 3.96); extrapulmonary tuberculosis 1.56 HR (95% CI 0.93 to 2.63); smoking 2.28 HR (95% CI 1.33 to 3.89); alcohol light 0.13 HR (95% CI 0.03 to 0.56).
  
  
  
  The probability of death in people living with HIV who default TB treatment is approximately four times greater when compared to those who do not default from treatment.
authors.affiliation: Department of Clinical Medicine, Universidade de Pernambuco, Rua Arnóbio Marques, 310 -Santo Amaro, Recife, PE CEP: 50100-130, Pernambuco, Brazil. rossanagcunha@yahoo.com.br.
authors.forename: R
authors.initials: R
authors.lastname: Cunha
authors.affiliation: Hospital Correia Picanço - HCP - Health State Department, Rua Padre Roma, 149, Tamarineira, Recife, PE CEP: 52050-150, Pernambuco, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Maruza
authors.affiliation: Department of Clinical Medicine, Universidade de Pernambuco, Rua Arnóbio Marques, 310 -Santo Amaro, Recife, PE CEP: 50100-130, Pernambuco, Brazil.
authors.forename: U R
authors.initials: UR
authors.lastname: Montarroyos
authors.affiliation: Hospital Universitário Oswaldo Cruz- HUOC- UPE, Rua Arnóbio Marques, 310 -Santo Amaro, Recife, PE CEP: 50100-130, Pernambuco, Brazil.
authors.forename: I
authors.initials: I
authors.lastname: Coimbra
authors.affiliation: Department of Clinical Medicine, Universidade de Pernambuco, Rua Arnóbio Marques, 310 -Santo Amaro, Recife, PE CEP: 50100-130, Pernambuco, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: de B Miranda-Filho
authors.affiliation: Aggeu Magalhães Research Center/Fiocruz, Av Moraes Rego, s/n - Campos da UFPE - Cidade Universitária, Recife, PE CEP: 50670420, Pernambuco, Brazil.
authors.forename: M de F
authors.initials: MF
authors.lastname: Albuquerque
authors.affiliation: Post-Graduation Program in Tropical Medicine - Universidade Federal de Pernambuco, Hospital das Clínicas - Bl. A - Térreo do HC/UFPE, Av. Prof. Moraes Rego - s/n. - Cidade Universitária, Recife, PE CEP: 50670-901, Pernambuco, Brazil.
authors.forename: H R
authors.initials: HR
authors.lastname: Lacerda
authors.affiliation: Department of Clinical Medicine, Universidade de Pernambuco, Rua Arnóbio Marques, 310 -Santo Amaro, Recife, PE CEP: 50100-130, Pernambuco, Brazil.|Post-Graduation Program in Tropical Medicine - Universidade Federal de Pernambuco, Hospital das Clínicas - Bl. A - Térreo do HC/UFPE, Av. Prof. Moraes Rego - s/n. - Cidade Universitária, Recife, PE CEP: 50670-901, Pernambuco, Brazil.
authors.forename: Raa
authors.initials: R
authors.lastname: Ximenes
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D012189:Retrospective Studies; D016019:Survival Analysis; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy*
keywords: Death; Default; Survival; Treatment; Tuberculosis