title: Prognostic value of circulating tumor DNA in patients with colon cancer: Systematic review.
abstract: The application of circulating tumor DNA(ctDNA) represents a non-invasive method for tumor detection. Its prognostic significance in patients with colorectal cancer is controversial. We performed a systematic review of data from published studies to assess the prognostic values of ctDNA in patients with colorectal cancer. We searched Medline, Embase, Web of Science, the Cochrane Library, and Scopus databases to identify eligible studies reporting disease-free survival (DFS) and overall survival (OS) stratified by ctDNA prior to December 6, 2016. We evaluated the quality and design of these studies. A total of 22 studies were eligible for systematic review. Among them, 11 studies investigated the prognostic value of ctDNA on disease-free survival (DFS). Seven of 11 studies showed that ctDNA was an independent variable to estimate the probability of DFS by multivariate analyses. Thirteen studies assessed the relationship between ctDNA and overall survival (OS). Eight of 13 studies showed that ctDNA was an independent predictor of worse OS through the use of multivariate analyses. This analysis provides evidence that ctDNA may be a prognostic biomarker, negatively correlated with the survival of patients with colorectal cancer.
authors.affiliation: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, China.|Department of Clinical Laboratory, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Gaowei
authors.initials: G
authors.lastname: Fan
authors.affiliation: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, China.
authors.forename: Kuo
authors.initials: K
authors.lastname: Zhang
authors.affiliation: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Clinical Laboratory, Shunyi Women and Children's Hospital of Beijing Children's Hospital, Beijing, China.
authors.forename: Zujian
authors.initials: Z
authors.lastname: Wang
authors.affiliation: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood*; D004273:DNA, Neoplasm / Q000097:blood*; D018572:Disease-Free Survival; D006801:Humans
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm