title: Emerging RNA editing biomarkers will foster drug development.
abstract: Unanticipated adverse drug reactions (ADRs) on the central nervous system are a major cause of clinical attrition and market withdrawal. Current practices for their prospective assessment still lean on extensive analysis of rodent behaviour despite their highly controversial predictive value. Human-derived in vitro models that objectively quantify mechanism-related biomarkers can greatly contribute to better ADR prediction at early developmental stages. Adenosine-to-inosine RNA editing constitutes a physiological cellular process that translates environmental cues by regulating protein function at the synaptic level in health and disease. Robust solutions based on NGS-based quantification of RNA editing biomarkers have emerged to predict the likelihood of treatment-related suicidal ideation and behaviour allowing cost-effective high-throughput drug screening as a strategy for risk mitigation.
authors.affiliation: Sys2Diag FRE3690 CNRS/ALCEDIAG, Complex System Modeling and Engineering for Diagnosis, Cap delta/Parc Euromédecine, 1682 rue de la Valsière CS 61003, 34184 Montpellier Cedex 4, France. Electronic address: siem.van-der-laan@sys2diag.cnrs.fr.
authors.forename: Siem
authors.initials: S
authors.lastname: van der Laan
authors.affiliation: Sys2Diag FRE3690 CNRS/ALCEDIAG, Complex System Modeling and Engineering for Diagnosis, Cap delta/Parc Euromédecine, 1682 rue de la Valsière CS 61003, 34184 Montpellier Cedex 4, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Salvetat
authors.affiliation: Sys2Diag FRE3690 CNRS/ALCEDIAG, Complex System Modeling and Engineering for Diagnosis, Cap delta/Parc Euromédecine, 1682 rue de la Valsière CS 61003, 34184 Montpellier Cedex 4, France.
authors.forename: Dinah
authors.initials: D
authors.lastname: Weissmann
authors.affiliation: Sys2Diag FRE3690 CNRS/ALCEDIAG, Complex System Modeling and Engineering for Diagnosis, Cap delta/Parc Euromédecine, 1682 rue de la Valsière CS 61003, 34184 Montpellier Cedex 4, France. Electronic address: franck.molina@sys2diag.cnrs.fr.
authors.forename: Franck
authors.initials: F
authors.lastname: Molina
mesh_terms: D000818:Animals; D015415:Biomarkers; D055808:Drug Discovery; D006801:Humans; D017393:RNA Editing; D059020:Suicidal Ideation
chemical_list: D015415:Biomarkers