title: Assessing the effect of 5-hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin.
abstract: BACKGROUND
  5-Hydroxymethylfurfural (5-HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti-allergic effect of 5-HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA).
  
  
  RESULTS
  Immunised animals had an increased level of serum total and OVA-specific antibodies when compared to the control (P < 0.01).We found that the OVA-induced increase in serum IgE and OVA-specific IgE were significantly suppressed in the groups treated with 5-HMF (P < 0.05). Moreover, interleukin-4 (IL-4) and interferon gamma (IFN-γ) were significantly reduced in a dose-independent manner when compared to the sensitised group (P < 0.05).
  
  
  CONCLUSIONS
  5-HMF inhibited the up-regulation of total and OVA-specific IgE through the suppression of the Th2-type immune response in immunised BALB/c mice. 5-HMF could therefore be a novel therapeutic approach for the prevention of IgE-mediated allergic diseases. © 2017 Society of Chemical Industry.
authors.affiliation: Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alizadeh
authors.affiliation: Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Khodaei
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Mesgari Abbasi
authors.affiliation: Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sevda
authors.initials: S
authors.lastname: Saleh-Ghadimi
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage*; D005260:Female; D005662:Furaldehyde / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D056724:Immunity, Humoral / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D015847:Interleukin-4; D007073:Immunoglobulin E; C008046:5-hydroxymethylfurfural; D007371:Interferon-gamma; D010047:Ovalbumin; D005662:Furaldehyde
keywords: 5-HMF; antibodies; cytokines; mice; ovalbumin