title: Impact of gluten-free diet on quality of life in celiac patients.
abstract: Celiac disease (CD) is a common gluten-related disorder, whose only treatment is a gluten-free diet (GFD). Since a unique view on psychological consequences of a GFD still lacks, our aim was to assess the quality of life (QoL) and the depression state in symptomatic CD patients after GFD. Socio-demographic features were considered.
  
  
  
  210 adult CD patients were recruited and divided into 3 groups : 70 newly diagnosed patients (​Group A​),70 patients who have been on GFD for 6-12 months (​Group B​), and 70 patients who have been on GFD for more than 12 months (​Group C​). We recruited 210 healthy controls (​Group D). Psychological General Well-Being Index (PGWBI) and Beck Depression Inventory (BDI) questionnaires were administered. Each group was evaluated according to age, gender and school ranking.
  
  
  
  Groups A ​and B showed lower PGWBI scores compared with both Group C ​and D (p <0.001 for each comparison). Moreover, Groups A and B showed higher BDI scores compared with both ​Group C ​and D (p <0.001 for each comparison).Women, the elderly and the poorly educated seemed to suffer more psychological stress.
  
  
  
  GFD induces an improvement of well-being and a decrease of depression state after 12 months of strict GFD. Negative psychological implications were observed only in specific risk categories. (Acta gastroenterol. belg., 2016, 79, 447-453).
authors.forename: R
authors.initials: R
authors.lastname: Borghini
authors.forename: M
authors.initials: M
authors.lastname: Di Tola
authors.forename: E
authors.initials: E
authors.lastname: Salvi
authors.forename: C
authors.initials: C
authors.lastname: Isonne
authors.forename: M
authors.initials: M
authors.lastname: Puzzono
authors.forename: M
authors.initials: M
authors.lastname: Marino
authors.forename: G
authors.initials: G
authors.lastname: Donato
authors.forename: A
authors.initials: A
authors.lastname: Picarelli
mesh_terms: D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000178:diet therapy*; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D013315:Stress, Psychological; D011795:Surveys and Questionnaires