title: Web-based hybrid-dimensional Visualization and Exploration of Cytological Localization Scenarios.
abstract: The CELLmicrocosmos 4.2 PathwayIntegration (CmPI) is a tool which provides hybrid-dimensional visualization and analysis of intracellular protein and gene localizations in the context of a virtual 3D environment. This tool is developed based on Java/Java3D/JOGL and provides a standalone application compatible to all relevant operating systems. However, it requires Java and the local installation of the software. Here we present the prototype of an alternative web-based visualization approach, using Three.js and D3.js. In this way it is possible to visualize and explore CmPI-generated localization scenarios including networks mapped to 3D cell components by just providing a URL to a collaboration partner. This publication describes the integration of the different technologies &ndash; Three.js, D3.js and PHP &ndash; as well as an application case: a localization scenario of the citrate cycle. The CmPI web viewer is available at: http://CmPIweb.CELLmicrocosmos.org.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kovanci
authors.forename: Mehmood
authors.initials: M
authors.lastname: Ghaffar
authors.forename: Björn
authors.initials: B
authors.lastname: Sommer
mesh_terms: D002460:Cell Line; D020407:Internet; D011381:Programming Languages