title: [Ocular manifestations of Zika virus: What we do and do not know].
abstract: Zika virus (ZIKV) disease outbreak, which was declared by the end of 2015 in Brazil, has become the largest one to date. Being reported in the Americas and in certain islands of the Pacific, it has the potential to spread worldwide. Although ZIKV infections are mostly self-limiting and/or asymptomatic in the healthy adult, they are responsible for devastating congenital neurologic malformations ZIKV (mainly microcephaly) when contracted during the first months of pregnancy. Ocular manifestations during the acute adult infection include conjunctivitis and more rarely ocular inflammation. Congenital infection is associated with chorioretinal atrophy pigment mottling of the retina retinal vasculature abnormalities and optic nerve atrophy. Therefore, complete ophthalmological evaluation is recommended for suspected congenital infections.
authors.affiliation: Service d'ophtalmologie, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, DHU vision et handicap, université Paris-Sud, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Benzekri
authors.affiliation: Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo and Vision Institute, São Paulo, Brésil.
authors.forename: R
authors.initials: R
authors.lastname: Belfort
authors.affiliation: Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo and Vision Institute, São Paulo, Brésil; Altino Ventura Foundation, Recife, Brésil; Department of Ophthalmology, Pernambuco's Eye Hospital (HOPE), Recife, Brésil.
authors.forename: C V
authors.initials: CV
authors.lastname: Ventura
authors.affiliation: Department of Ophthalmology, Hospital Geral Roberto Santos, Salvador, Brésil.
authors.forename: B
authors.initials: B
authors.lastname: de Paula Freitas
authors.affiliation: Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo and Vision Institute, São Paulo, Brésil.
authors.forename: M
authors.initials: M
authors.lastname: Maia
authors.affiliation: Service d'ophtalmologie, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, DHU vision et handicap, université Paris-Sud, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Leite
authors.affiliation: Service d'ophtalmologie, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, DHU vision et handicap, université Paris-Sud, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; UMR 1184, Immunologie des infections virales et maladies auto-immunes, commissariat à l'énergie atomique et aux énergies alternatives, Fontenay-aux-Roses, France.
authors.forename: M
authors.initials: M
authors.lastname: Labetoulle
authors.affiliation: Service d'ophtalmologie, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, DHU vision et handicap, université Paris-Sud, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; UMR 1184, Immunologie des infections virales et maladies auto-immunes, commissariat à l'énergie atomique et aux énergies alternatives, Fontenay-aux-Roses, France. Electronic address: antoine.rousseau@aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Rousseau
mesh_terms: D001938:Brazil / Q000453:epidemiology; D004196:Disease Outbreaks; D058872:Epidemics; D015828:Eye Infections, Viral / Q000151:congenital / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data; D015997:Neonatal Screening / Q000379:methods; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D000071243:Zika Virus Infection / Q000151:congenital / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*
keywords: Conjonctivite; Conjunctivitis; Epidemics; Maculopathie; Maculopathy; Microcephaly; Microcéphalie; Uveitis; Uvéite; Virus; Zika; Épidémie