title: Morinda citrifolia(Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis.
abstract: Morinda citrifoliaL. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-αand IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease.
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Coutinho de Sousa
authors.affiliation: Institute of Tropical Pathology and Public Health, Federal University of Goias, 74605-050 Goiania, GO, Brazil.
authors.forename: Juliana
authors.identifier: 0000-0002-0471-1454
authors.initials: J
authors.lastname: Reis Machado
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Marcos Vinicius
authors.identifier: 0000-0002-2966-7621
authors.initials: MV
authors.lastname: da Silva
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Thiago Alvares
authors.initials: TA
authors.lastname: da Costa
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Javier Emilio
authors.initials: JE
authors.lastname: Lazo-Chica
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Thatiane do Prado
authors.initials: TD
authors.lastname: Degasperi
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Virmondes
authors.initials: V
authors.lastname: Rodrigues Junior
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Helioswilton
authors.identifier: 0000-0003-3252-2834
authors.initials: H
authors.lastname: Sales-Campos
authors.affiliation: Department of Pharmaceutical Sciences, University of Uberaba, 38050-501 Uberaba, MG, Brazil.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Uber Bucek
authors.affiliation: Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
authors.forename: Carlo José
authors.identifier: 0000-0003-2211-7333
authors.initials: CJ
authors.lastname: Freire Oliveira
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003092:Colitis / Q000139:chemically induced* / Q000188:drug therapy*; D016264:Dextran Sulfate / Q000633:toxicity*; D000067030:Fruit and Vegetable Juices; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D016264:Dextran Sulfate