title: Designed Synthesis of Lipid-Coated Polyacrylic Acid/Calcium Phosphate Nanoparticles as Dual pH-Responsive Drug-Delivery Vehicles for Cancer Chemotherapy.
abstract: Herein, we report a facile strategy to prepare supported lipid-bilayer-coated polyacrylic acid/calcium phosphate nanoparticles (designated as PAA/CaP@SLB NPs) as a new dual pH-responsive drug-delivery platform for cancer chemotherapy. The synthesized PAA/CaP NPs exhibited both a high payload of doxorubicin (DOX) and dual pH-responsive drug-release properties. Additionally, the coated lipid bilayer had the ability to enhance the cellular uptake of PAA/CaP NPs without affecting the pH-responsive drug release. Moreover, the blank PAA/CaP@SLB NPs exhibited excellent biocompatibility and the DOX-loaded PAA/CaP@SLB NPs markedly increased the cellular accumulation of DOX and its cytotoxic effects on HepG-2 cells. Furthermore, when used to evaluate the in vivo therapeutic efficacy in mice with the hepatocarcinoma cell line (H-22), the DOX-loaded PAA/CaP@SLB NPs exhibited superior inhibition of tumor growth compared with the free DOX group. Thus, PAA/CaP@SLB NPs are a promising drug-delivery vehicle to increase the therapeutic efficacy of anticancer drugs.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Manjie
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Lingyu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Li
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Chungang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Su
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
authors.forename: Weisan
authors.initials: W
authors.lastname: Pan
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D002130:Calcium Phosphates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D015195:Drug Design; D065546:Drug Liberation; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D014183:Transplantation, Heterologous
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D002130:Calcium Phosphates; D004337:Drug Carriers; D008051:Lipid Bilayers; D008055:Lipids; C006903:carbopol 940; D004317:Doxorubicin
keywords: antitumor agents; drug delivery; lipids; nanoparticles; pH response