title: Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging.
abstract: The Receptor for Activated C Kinase 1 (RACK1) is a scaffold protein for different kinases and membrane receptors. RACK1 can shuttle proteins to their sites of action, facilitate cross-talk among distinct signaling pathways or recruit other signaling proteins into the complexes. Therefore, it is a key mediator of various pathways and is involved in various biological events including development, immune response, brain activity and cancer. Because of its importance, it is of extreme significance to understand the transcriptional mechanisms governing its expression. The identification of regulatory elements in the promoter of RACK1 shed some light on its transcriptional modulation in physiological and pathological context. Literature data support the existence of a complex hormonal balance, between glucocorticoids and androgens, in the control of RACK1 expression due to specific and complex interactions on the RACK1 promoter. These and other informations suggest that a better understanding of RACK1 transcriptional regulation is essential to unravel its role. Furthermore, the modulation of its expression in physiological or pathological conditions may be of interest in different context, such as aging and cancer.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Buoso
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy.
authors.forename: Marilisa
authors.initials: M
authors.lastname: Galasso
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy; Scuola Universitaria Superiore IUSS Pavia, Piazza della Vittoria n.15, 27100 Pavia, Italy.
authors.forename: Melania Maria
authors.initials: MM
authors.lastname: Serafini
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy.
authors.forename: Melania
authors.initials: M
authors.lastname: Ronfani
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Lanni
authors.affiliation: Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Corsini
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy. Electronic address: racchi@unipv.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Racchi
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D011401:Promoter Regions, Genetic; D000075370:Receptors for Activated C Kinase / Q000235:genetics*; D011956:Receptors, Cell Surface; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D009363:Neoplasm Proteins; C419368:RACK1 protein, human; D000075370:Receptors for Activated C Kinase; D011956:Receptors, Cell Surface
keywords: Aging; Cancer; GNB2L1; Gene promoter; Immune system; RACK1; Signal transduction; Steroid hormones; Transcription factors; rack1 gene