title: Graphene/Intermetallic PtPb Nanoplates Composites for Boosting Electrochemical Detection of H2O2Released from Cells.
abstract: Rational design and construction of electrocatalytic nanomaterials is vital for improving the sensitivity and selectivity of nonenzymatic electrochemical sensors. Here, we report a novel graphene supported intermetallic PtPb nanoplates (PtPb/G) nanocomposite as an enhanced electrochemical sensing platform for high-sensitivity detection of H2O2in neutral solution and also released from the cells. The intermetallic PtPb nanoplates are first synthesized via a simple wet-chemistry process and subsequently assembled on graphene via a solution-phase self-assembly approach. The obtained nanocomposite exhibits excellent electrocatalytic activity for the electrochemical reduction of H2O2in a half-cell test and can detect H2O2with a wide linear detection range of 2 nM to 2.5 mM and a very low detection limit of 2 nM. Under the same conditions, the sensitivity of PtPb/G for the detection of H2O2is more than 12.7 times higher than that of commercial Pt/C. The high-density of electrocatalytic active sites on the unique PtPb nanoplates and the synergistic effect between PtPb nanoplates and graphene appear to be the main factors in contributing to the outstanding electroanalytical performance. The PtPb/G can be also used for the practical detection of H2O2released from Raw 264.7 cells.
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University , Beijing 100871, China.|College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Mingchuan
authors.initials: M
authors.lastname: Luo
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Xiangxi
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.affiliation: College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.
authors.forename: Lei
authors.identifier: 0000-0001-7275-4846
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Ren
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University , Beijing 100871, China.|BIC-ESAT, College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Shaojun
authors.identifier: 0000-0003-4427-6837
authors.initials: S
authors.lastname: Guo
mesh_terms: D000818:Animals; D002384:Catalysis; D055664:Electrochemical Techniques; D006108:Graphite / Q000138:chemical synthesis / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000378:metabolism; D007854:Lead / Q000737:chemistry*; D051379:Mice; D053761:Nanocomposites; D010984:Platinum / Q000737:chemistry*; D000067996:RAW 264.7 Cells
chemical_list: D007854:Lead; D010984:Platinum; D006108:Graphite; D006861:Hydrogen Peroxide