title: New insights into genotype-phenotype correlation in individuals with different level of general non-specific reactivity of an organism.
abstract: The objective of the study was to investigate the genetic basis of general non-specific reactivity of an organism. Systematic search in PubMedCentral, PDB, KEGG and SNP databases identified a set of genes and their polymorphisms that can determine pain sensitivity and therefore the level of general non-specific reactivity of the human organism. Six SNPs were selected for genotyping kit design; 230 healthy volunteers were enrolled in the study. It was revealed that very high pain threshold was associated with allele A in rs1851048 and allele C in rs6777055. High level of general non-specific reactivity of an organism was associated with allele G in rs2562456 (OR=1.804, CI=1.139-2.857, p=0.011) and allele C in rs6923492 (OR=1.582, CI=1.071-2.335, p=0.021). Low level of general non-specific reactivity of an organism was associated with allele T in rs6923492 (OR=0.351, CI=0.154-0.799, p=0.010). A set of genes and single-nucleotide polymorphisms associated with the pain sensitivity and indirectly with the level of general non-specific reactivity of human organism were determined. The identified correlations reveal some molecular mechanisms of general non-specific reactivity of an organism variability and can guide further research in this area.
authors.forename: Alexander
authors.initials: A
authors.lastname: Mulik
authors.forename: Valery
authors.initials: V
authors.lastname: Novochadov
authors.forename: Alexander
authors.initials: A
authors.lastname: Bondarev
authors.forename: Sofya
authors.initials: S
authors.lastname: Lipnitskaya
authors.forename: Irina
authors.initials: I
authors.lastname: Ulesikova
authors.forename: Yulia
authors.initials: Y
authors.lastname: Shatyr
mesh_terms: D000293:Adolescent; D000328:Adult; D030541:Databases, Genetic; D005260:Female; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult