title: Mice and the A-Bomb: Irradiation Systems for Realistic Exposure Scenarios.
abstract: Validation of biodosimetry assays is normally performed with acute exposures to uniform external photon fields. Realistically, exposure to a radiological dispersal device or reactor leak will include exposure to low dose rates and likely exposure to ingested radionuclides. An improvised nuclear device will likely include a significant neutron component in addition to a mixture of high- and low-dose-rate photons and ingested radionuclides. We present here several novel irradiation systems developed at the Center for High Throughput Minimally Invasive Radiation Biodosimetry to provide more realistic exposures for testing of novel biodosimetric assays. These irradiators provide a wide range of dose rates (from Gy/s to Gy/week) as well as mixed neutron/photon fields mimicking an improvised nuclear device.
authors.affiliation: a   Radiological Research Accelerator Facility, Columbia University, Irvington, New York 10533; and.
authors.forename: Guy
authors.initials: G
authors.lastname: Garty
authors.affiliation: a   Radiological Research Accelerator Facility, Columbia University, Irvington, New York 10533; and.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Xu
authors.affiliation: b   Center for Radiological Research, Columbia University, New York, New York 10032.
authors.forename: Carl
authors.initials: C
authors.lastname: Elliston
authors.affiliation: a   Radiological Research Accelerator Facility, Columbia University, Irvington, New York 10533; and.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Marino
authors.affiliation: a   Radiological Research Accelerator Facility, Columbia University, Irvington, New York 10533; and.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Randers-Pehrson
authors.affiliation: b   Center for Radiological Research, Columbia University, New York, New York 10032.
authors.forename: David J
authors.initials: DJ
authors.lastname: Brenner
mesh_terms: D000818:Animals; D001769:Blood / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D051379:Mice; D008962:Models, Theoretical; D009502:Neutrons; D054043:Nuclear Weapons; D000069079:Radiation Exposure / Q000032:analysis*; D011834:Radiation Monitoring / Q000379:methods*; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods*