title: Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines.
abstract: Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund's adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Waleed M
authors.initials: WM
authors.lastname: Hussein
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Saori
authors.initials: S
authors.lastname: Mukaida
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Faculty of Pharmacy, National University of Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Fazren
authors.initials: F
authors.lastname: Azmi
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Stacey
authors.initials: S
authors.lastname: Bartlett
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Celine
authors.initials: C
authors.lastname: Olivier
authors.affiliation: Institute for Glycomics, Griffith University , Gold Coast, QLD 4215, Australia.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Batzloff
authors.affiliation: Institute for Glycomics, Griffith University , Gold Coast, QLD 4215, Australia.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Good
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Skwarczynski
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
keywords: Fluorinated lipid; cellular immunity; humoral immunity; nanoparticle; peptide-based vaccine; self-adjuvant