title: Correcting for non-compliance when determining colonic transit time with radio-opaque markers.
abstract: The use of radio-opaque markers and abdominal X-ray is the standard method for determining colonic transit time (CTT). However, when there are deviations in the intake of these markers by participants in clinical trials it is desirable to improve observations by introducing corrections, where possible. To date, there is no standard procedure to adjust for such deviations. This report proposes a series of alternatives based on possible scenarios for deviations from the intended intake of radio-opaque markers. The proposed method to correct for missed or delayed consumption of radio-opaque markers can help to increase the accuracy of the CTT measurements in clinical trials.
authors.affiliation: Alvin Ibarra, Kaisa Olli, Arthur C Ouwehand, DuPont Nutrition and Health, 02460 Kantvik, Finland.
authors.forename: Alvin
authors.initials: A
authors.lastname: Ibarra
authors.affiliation: Alvin Ibarra, Kaisa Olli, Arthur C Ouwehand, DuPont Nutrition and Health, 02460 Kantvik, Finland.
authors.forename: Kaisa
authors.initials: K
authors.lastname: Olli
authors.affiliation: Alvin Ibarra, Kaisa Olli, Arthur C Ouwehand, DuPont Nutrition and Health, 02460 Kantvik, Finland.
authors.forename: Arthur C
authors.initials: AC
authors.lastname: Ouwehand
mesh_terms: D015415:Biomarkers; D003106:Colon; D003248:Constipation; D005772:Gastrointestinal Transit; D006801:Humans; D011859:Radiography; D011860:Radiography, Abdominal
chemical_list: D015415:Biomarkers
keywords: Colonic transit time; Gastroenterology; Gut transit time; Radio-opaque marker; X-ray