title: P300 Wave Changes in Patients with Parkinson's Disease.
abstract: BACKGROUND
  Parkinson's disease (PD) is chronic progressive neurodegenerative disease. In patients with Parkinson's disease among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes.
  
  
  OBJECTIVE
  The aim of this study was to demonstrate that patients with Parkinson's disease have reduced amplitude and prolonged latency, longer than 300 ± 10 ms.
  
  
  METHODS
  The study included 21 patient suffering from Parkinson's disease. After reviewing the medical records and analyzes the inclusion and exclusion criteria, patients were subjected to the same procedure examining auditory cognitive potentials (P300 wave) and the results were analyzed and compared to reference value for healthy population.
  
  
  RESULTS
  We have shown that patients with Parkinson's disease have prolonged P300 targeted and frequent stimulus latency compared to reference value for healthy population. From 21 patient 18 had a pathological P300 target stimulus amplitude, and even 20 patients had pathological P300 frequent stimulus amplitude.
  
  
  CONCLUSIONS
  People with Parkinson's disease have altered P300 which indicates the presence of cognitive dysfunction in these patients.
authors.affiliation: School of Medicine, University of Split, Split, Croatia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Tokic
authors.affiliation: School of Medicine, University of Split, Split, Croatia; Department of Neurology, University Hospital Split, Split, Croatia.
authors.forename: Marina
authors.initials: M
authors.lastname: Titlic
authors.affiliation: Department of Neurology, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
authors.forename: Amira
authors.initials: A
authors.lastname: Beganovic-Petrovic
authors.affiliation: Department of Neurology, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
authors.forename: Enra
authors.initials: E
authors.lastname: Suljic
authors.affiliation: Department of Neurology, University Hospital Split, Split, Croatia.
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Romac
authors.affiliation: Department of Neurology, University Hospital Split, Split, Croatia.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Silic
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000503:physiopathology*; D010775:Photic Stimulation; D011930:Reaction Time; D012016:Reference Values
keywords: P300; Parkinson’s disease; auditory evoked potentials; cognitive dysfunction