title: Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation.
abstract: Homeostatic rebound in rapid eye movement (REM) sleep normally occurs after acute sleep deprivation, but REM sleep rebound settles on a persistently elevated level despite continued accumulation of REM sleep debt during chronic sleep restriction (CSR). Using high-density EEG in mice, we studied how this pattern of global regulation is implemented in cortical regions with different functions and network architectures. We found that across all areas, slow oscillations repeated the behavioral pattern of persistent enhancement during CSR, whereas high-frequency oscillations showed progressive increases. This pattern followed a common rule despite marked topographic differences. The findings suggest that REM sleep slow oscillations may translate top-down homeostatic control to widely separated brain regions whereas fast oscillations synchronizing local neuronal ensembles escape this global command. These patterns of EEG oscillation changes are interpreted to reconcile two prevailing theories of the function of sleep, synaptic homeostasis and sleep dependent memory consolidation.
authors.affiliation: Center for Neuroscience, Korea Institute of Science and Technology, Seoul 02792, South Korea.|Department of Neuroscience, University of Science and Technology, Daejeon 34113, South Korea.
authors.forename: Bowon
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA 02215; bernat_kocsis@hms.harvard.edu jeechoi@kist.re.kr.|Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215.
authors.forename: Bernat
authors.initials: B
authors.lastname: Kocsis
authors.affiliation: Center for Neuroscience, Korea Institute of Science and Technology, Seoul 02792, South Korea.
authors.forename: Eunjin
authors.initials: E
authors.lastname: Hwang
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA 02215.|Research Service, Veterans Affairs Boston Healthcare System, Brockton, MA 02301.
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA 02215.|Research Service, Veterans Affairs Boston Healthcare System, Brockton, MA 02301.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Strecker
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA 02215.|Research Service, Veterans Affairs Boston Healthcare System, Brockton, MA 02301.
authors.forename: Robert W
authors.initials: RW
authors.lastname: McCarley
authors.affiliation: Center for Neuroscience, Korea Institute of Science and Technology, Seoul 02792, South Korea; bernat_kocsis@hms.harvard.edu jeechoi@kist.re.kr.|Department of Neuroscience, University of Science and Technology, Daejeon 34113, South Korea.
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D008568:Memory / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology*
keywords: EEG topography; chronic sleep deprivation; fast cortical oscillation; low-frequency cortical oscillation; sleep function