title: Association of sleep quality in Behcet disease with disease activity, depression, and quality of life in Korean population.
abstract: OBJECTIVE
  Sleep disturbance is prime concern in patients with Behcet disease. The purpose of this study was to find out the effects of sleep quality, in Korean patients suffering from Behcet disease. We further investigated the relationship between depression, quality of life and the clinical findings of Behcet disease.
  
  
  METHODS
  The study was performed by the cross-sectional design. Sleep quality was assessed by the Korean version of Pittsburgh sleep quality index (PSQI). Disease activity of Behcet disease was evaluated by Behcet disease current activity form (BDCAF). Depression was assessed by the Korean version of Beck depression inventory second edition (BDI-2). Quality of life was assessed by the Korean version of the Leeds Behcet disease quality of life measure (BDQoL).
  
  
  RESULTS
  Among the 100 patients studied, 42% reported poor sleep quality (PSQI ≥ 9). These patients have a higher BDI-2, total BDCAF and pain visual analogue scale (VAS) score (p< 0.001,p= 0.022, andp= 0.005). Considering BDCAF, the frequency of genital ulcer was significantly higher (p= 0.01). Behcet was higher in females. The BDQoL was lower in poor sleeper group (p= 0.004 andp< 0.001). Among 7 PSQI components, daytime dysfunction was higher in patients with high disease activity (p= 0.03). Total PSQI score were strongly correlated with BDCAF, BDI-2, BDQoL, and pain VAS score (p= 0.02,p< 0.001,p< 0.001, andp< 0.001, respectively).
  
  
  CONCLUSIONS
  Low sleep quality is directly associated with disease activity, depression, and quality of life in Korean patients with Behcet disease.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Jimin
authors.initials: J
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Jeong
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Chang-Nam
authors.initials: CN
authors.lastname: Son
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Yong-Won
authors.initials: YW
authors.lastname: Cho
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Sang-Hyon
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D056910:Republic of Korea; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000209:etiology*
keywords: Behcet syndrome; Sleep quality