title: Generation of induced cardiac progenitor cells via somatic reprogramming.
abstract: It has been demonstrated that cardiac progenitor cells (CPCs) represent a more effective cell-based therapy for treatment of myocardial infarction. Unfortunately, their therapeutic application is limited by low yield of cell harvesting, declining quality and quantity during the ageing process, and the need for highly invasive heart biopsy. Therefore, there is an emerging interest in generating CPC-like stem cells from somatic cells via somatic reprogramming. This novel approach would provide an unlimited source of stem cells with cardiac differentiation potential. Here we would firstly discuss the different types of CPC and their importance in stem cell therapy for treatment of myocardial infarction; secondly, the necessity of generating induced CPC from somatic cells via somatic reprogramming; and finally the current progress of somatic reprogramming in cardiac cells, especially induced CPC generation.
authors.affiliation: Institute of Biological Therapy, Shenzhen University, Shenzhen, China.|Department of Pathogen Biology and Immunology, Shenzhen University School of Medicine, Shenzhen, China.|Shenzhen City Shenzhen University Immunodiagnostic Technology Platform, Shenzhen, China.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Xu
authors.affiliation: Institute of Biological Therapy, Shenzhen University, Shenzhen, China.|Department of Pathogen Biology and Immunology, Shenzhen University School of Medicine, Shenzhen, China.|Shenzhen City Shenzhen University Immunodiagnostic Technology Platform, Shenzhen, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lian
authors.affiliation: Institute of Biological Therapy, Shenzhen University, Shenzhen, China.|Department of Pathogen Biology and Immunology, Shenzhen University School of Medicine, Shenzhen, China.|Shenzhen City Shenzhen University Immunodiagnostic Technology Platform, Shenzhen, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Biological Therapy, Shenzhen University, Shenzhen, China.|Department of Pathogen Biology and Immunology, Shenzhen University School of Medicine, Shenzhen, China.|Shenzhen City Shenzhen University Immunodiagnostic Technology Platform, Shenzhen, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Huang
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D065150:Cellular Reprogramming / Q000235:genetics*; D000067470:Cellular Reprogramming Techniques / Q000379:methods*; D006801:Humans; D032386:Myoblasts, Cardiac / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction
keywords: CPC; cardiac progenitor cell; induced CPC; somatic reprogramming