title: Dexmedetomidine-induced neuroprotection: is it translational?
abstract: Dexmedetomidine is often used in anesthesia and critical care medicine practice to sedate patients. Its neuroprotective effects have been shown in various ischemic and hemorrhagic brain injury models of animals. Randomized clinical trials have indicated that dexmedetomidine can improve outcome of patients under intensive care. Clinical trials are needed to determine whether dexmedetomidine can provide neuroprotection against ischemic and hemorrhagic stroke.
authors.affiliation: Department of Anesthesiology, University of Virginia, Charlottesville, Virginia 22901, USA; Department of Anesthesiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Yunzhen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Ruquan
authors.initials: R
authors.lastname: Han
authors.affiliation: Department of Anesthesiology, University of Virginia, Charlottesville, Virginia 22901, USA.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Zuo
keywords: Dexmedetomidine; ICU; ischemic stroke; neuroprotection