title: Effectiveness and safety of topical tacrolimus in treatment of vitiligo.
abstract: Vitiligo is one of the most primitive well-known dermatoid disorders with different suggested therapies. Therefore, this study investigated the efficiency and safety of topical tacrolimus in treatment of patients with vitiligo. This study was a clinical randomized designed study pre- post-test method, has been conducted on thirty cases with vitiligo who have referred to polyclinic and dermatology clinic. Participant's evaluated and demographic information recorded in designed checklist. In the next stage, the disease activity scored by vitiligo index disease activity system. Photography and depigmentation percent has recorded before treatment and further in 4th, 8th, 12th, 16th, 20th, and 24thweeks. Finally, gathered data compared through SPSS-20 software. The final sample comprised 30 persons including: 12 men (40%) and 18 women (60%). The average of patient's age in this study was 26/13 ± 18/20 (2-76-year-old). Eleven persons was ≤15 years old and rest was older than 15. Sixty-six lesions have funded in patients that maximum has accrued on face and neck (37/87%) and trunk (21/21%). In addition, minimum of lesions is related to genitalia (9/09%). In the in 4th, 8th, 12th, 16thweeks, improvement in face and neck had increased significantly, into the past weeks. In the 20thand 24thweeks, the improvement has increased although it was not significant enhancement. Also about trunk, in the 4thweek the improvement does not have significant increasing in compare to the past week. In the eighth, 12th, 16th, 20th, and 24thweeks the improvement has been increased significantly in compare to the past weeks. Although in the case of limbs and genitalia, the improvement was lower. There was no significant difference between male and females and age. Although the improvement was, slow in older persons. Study results, has presented applying topical tacrolimus in vitiligo, particularly in face and neck, could be effective and does not seen any specified adverse effects during consumption of tacrolimus, it could be effective in decreasing effects in use of corticosteroid.
authors.affiliation: Department of Dermatology, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Ghasem Rahmatpour
authors.initials: GR
authors.lastname: Rokni
authors.affiliation: Department of Dermatology, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Golpour
authors.affiliation: Education and Development Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Alimorad Heidari
authors.initials: AH
authors.lastname: Gorji
authors.affiliation: Department of Epidemiology and Biostatistics, Health Science Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Khalilian
authors.affiliation: GP, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Hamta
authors.initials: H
authors.lastname: Ghasemi
keywords: Safety; topical tacrolimus; vitiligo