title: MSMB gene rs10993994 polymorphism increases the risk of prostate cancer.
abstract: Genome-wide association studies (GWASs) identified microseminoprotein-β (MSMB) gene rs10993994 polymorphism was significantly associated with prostate cancer (PC) risk. However, the association between MSMB gene rs10993994 polymorphism and PC risk remains controversial. Therefore, we performed a systematic review and meta-analysis by searching in the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 11 publications containing 13 case-control studies for rs10993994 polymorphism were included in our analysis. Our data indicated that MSMB gene rs10993994 polymorphism was associated with an increased risk of PC. Stratification analyses of ethnicity suggested rs10993994 polymorphism increased the risk of PC among Caucasians, but not among Asians. In conclusion, this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC.
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Nantong University, Wuxi, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.affiliation: Department of Urology, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu Province, PR China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Nantong University, Wuxi, PR China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Nantong University, Wuxi, PR China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Mi
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D029584:Prostatic Secretory Proteins / Q000235:genetics*; D017594:Publication Bias
chemical_list: D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein
keywords: MSMB; meta-analysis; prostate cancer; rs10993994; single nucleotide polymorphism