title: Calcium-binding protein, secretagogin, characterizes novel groups of interneurons in the rat striatum.
abstract: In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transferase (ChAT). 60-70% of SCGN positive striatal neurons contained either PV or CR or ChAT, but none contained NOS. On the other hand the remaining 30-40% expressed none of these markers, most of which were GAD positive. The present study indicates that there are hitherto unknown groups of striatal interneurons in the rat striatum.
authors.affiliation: Department of Medical Science Technology, Faculty of Health and Welfare Sciences in Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Okawa City, Fukuoka 831-8501, Japan. Electronic address: t-kosaka@iuhw.ac.jp.
authors.forename: Toshio
authors.initials: T
authors.lastname: Kosaka
authors.affiliation: Department of Medical Science Technology, Faculty of Health and Welfare Sciences in Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Okawa City, Fukuoka 831-8501, Japan.
authors.forename: Seiko
authors.initials: S
authors.lastname: Yasuda
authors.affiliation: Department of Medical Science Technology, Faculty of Health and Welfare Sciences in Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Okawa City, Fukuoka 831-8501, Japan.
authors.forename: Katsuko
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D064032:Calbindin 2 / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology* / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007395:Interneurons / Q000378:metabolism*; D008297:Male; D051379:Mice; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism; D051381:Rats; D064046:Secretagogins / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D015415:Biomarkers; C576512:Calb2 protein, rat; D064032:Calbindin 2; D010320:Parvalbumins; C576558:SCGN protein, rat; D064046:Secretagogins; D019001:Nitric Oxide Synthase; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase
keywords: Calretinin; Choline acetyl transferase; GABA; Heterogeneity; Nitric oxide synthase; Parvalbumin