title: Gene Polymorphism-related Individual and Interracial Differences in the Outcomes of Androgen Deprivation Therapy for Prostate Cancer.
abstract: Among patients with prostate cancer, the prognosis after androgen deprivation therapy differs significantly among individuals and among races; however, the reasons underlying these differences are poorly understood. Several single nucleotide polymorphisms in genes associated with prostate cancer progression or castration resistance might serve as the host factor that influences prognosis and, thus, accounts for these individual and racial gaps in treatment outcomes. Accordingly, single nucleotide polymorphisms associated with treatment outcomes could be used as predictive and/or prognostic biomarkers for patient stratification and to identify personalized treatment and follow-up protocols. The present review has summarized the genetic polymorphisms that have been reported to associate with androgen deprivation therapy outcomes among patients with prostate cancer and compared the allele frequencies among different ethnic groups.
authors.affiliation: Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. Electronic address: n-fuji@med.uoeh-u.ac.jp.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Fujimoto
authors.affiliation: Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Shiota
authors.affiliation: Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Ikko
authors.initials: I
authors.lastname: Tomisaki
authors.affiliation: Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Minato
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D018450:Disease Progression; D006801:Humans; D008297:Male; D000071184:Pharmacogenomic Variants; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000208:ethnology* / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists
keywords: ADT; Gene polymorphism; Oncologic outcome; Prostate cancer; Racial difference