title: Factors associated with reduction of left ventricular mass in children on peritoneal dialysis.
abstract: OBJECTIVE
  This study aimed to investigate sensitive factors involved in left ventricular mass reduction in children with end-stage renal disease (ESRD) undergoing peritoneal dialysis.
  
  
  METHODS
  Thirty-five subjects on peritoneal dialysis were enrolled. Two successive echocardiographic and clinical data for each subject were obtained. Blood pressure and left ventricular mass index (LVMI) were indexed through a division with the normal 95thpercentile value. Differences in numeric data between two datasets were calculated.
  
  
  RESULTS
  The mean age was 12.9 ± 4.6 years. Predictors of left ventricular hypertrophy and its persistence were systolic blood pressure index (P = 0.019 and P = 0.046) and E' velocity (P = 0.035 and P = 0.031) in univariate analysis. However, differences in these predictors between the datasets were not related to the change in indexed LVMI. Reduction in indexed LVMI was correlated to a reduction of indexed left atrial volume (R = 0.638, P = 0.001), trans-mitral A velocity (R = 0.443, P = 0.011), and serum blood urea nitrogen level (R = 0.372, P = 0.028) and an elevation of haemoglobin level (R = -0.374, P = 0.027).
  
  
  CONCLUSIONS
  The extent of circulating volume expansion is potentially the main predictive factor for change of LVMI, because the volume dependent diastolic functional variables correlate to the change of LVMI. Further study with a large number of ESRD children including a group under fluid volume control is needed to investigate the role of volume expansion on the change of LVMI.
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Yu
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hyun Ok
authors.initials: HO
authors.lastname: Jun
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Shin
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jae Suk
authors.initials: JS
authors.lastname: Baek
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Joo Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Young-Hwue
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Young Seo
authors.initials: YS
authors.lastname: Park
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jae-Kon
authors.initials: JK
authors.lastname: Ko
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010530:Peritoneal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
keywords: child; end-stage renal disease; hypertension; left atrial volume; left ventricular hypertrophy; peritoneal dialysis