title: Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction.
abstract: Due to their capacity to self-renew, proliferate and generate multi-lineage cells, adult-derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer's disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose-derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose-derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications. Stem Cells Translational Medicine 2017;6:1096-1108.
authors.affiliation: Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
authors.forename: Jordan A
authors.initials: JA
authors.lastname: Dykstra
authors.affiliation: Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Facile
authors.affiliation: Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Patrick
authors.affiliation: Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.|Department of Pediatrics, The University of South Dakota Sanford School of Medicine, Vermillion, South Dakota, USA.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Francis
authors.affiliation: Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.|Department of Pediatrics, The University of South Dakota Sanford School of Medicine, Vermillion, South Dakota, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Milanovich
authors.affiliation: Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.|Department of Pediatrics, The University of South Dakota Sanford School of Medicine, Vermillion, South Dakota, USA.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Weimer
authors.affiliation: Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Kota
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D044968:Regenerative Medicine / Q000379:methods; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology
keywords: Adipose; Adult stem cells; Autologous stem cell transplantation; Cellular therapy; Clinical trials; Mesenchymal stem cells