title: Amelioration of experimental autoimmune encephalomyelitis through transplantation of placental derived mesenchymal stem cells.
abstract: Placental derived mesenchymal stem cells (PMSCs) have been suggested as a possible source of cells to treat multiple sclerosis (MS) due to their immunomodulatory functions, lack of ethical concerns, and potential to differentiate into neurons and oligodendrocytes. To investigate whether PMSCs share similar characteristics with embryonic mesenchymal stem cells (EMSCs), and if transplanted PMSCs have the ability to integrate and replace degenerated neural cells, we transplanted rat PMSCs and EMSCs into the central nervous system (CNS) of Lewis rats with experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Our findings demonstrated that transplanted PMSCs, similar to EMSCs, were effective in decreasing infiltrating inflammatory cells, preserving axons, and ameliorating demyelination, thereby improving the neurological functions of animals. Moreover, both PMSCs and EMSCs had the ability to migrate into inflamed tissues and express neural-glial lineage markers. These findings suggest that PMSCs may replace EMSCs as a source of cells in MS stem cell therapy.
authors.affiliation: Department of Electrophysiology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Tian
authors.affiliation: Core Facilities, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Wang
authors.affiliation: Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Han
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000628:therapy*; D005260:Female; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D010920:Placenta / Q000166:cytology; D011247:Pregnancy; D051381:Rats; D011917:Rats, Inbred Lew; D012038:Regeneration