title: [Prediabetes as a riskmarker for stress-induced hyperglycemia in critically ill adults].
abstract: BACKGROUND
  It is not known if patients with prediabetes, a subgroup of non-diabetic patients that usually present hyperinsulinemia, have higher risk to present stress-induced hyperglycemia. The objective was to determine if prediabetes is a risk marker to present stress-induced hyperglycemia.
  
  
  METHODS
  Analytic, observational, prospective cohort study of non-diabetic critically ill patients of a third level hospital. We determined plasmatic glucose and glycated hemoglobin (HbA1c) at admission to diagnose stress-induced hyperglycemia (glucose ≥ 140 mg/dL) and prediabetes (HbA1c between 5.7 and 6.4%), respectively. We examined the proportion of non-prediabetic and prediabetic patients that developed stress hyperglycemia with contingence tables and Fisher's exact test for nominal scales.
  
  
  RESULTS
  Of 73 patients studied, we found a proportion of stress-induced hyperglycemia in 6.6% in those without prediabetes and 61.1% in those with prediabetes. The Fisher's exact test value was 22.46 (p < 0.05).
  
  
  CONCLUSIONS
  Prediabetes is a risk marker for stress-induced hyperglycemia in critically ill adults.
authors.affiliation: Unidad de Cuidados Intensivos, Centro Médico Nacional del Bajío, Instituto Mexicano del Seguro Social, León, Guanajuato, México. eliseoluis64@hotmail.com.
authors.forename: Diego Jesús
authors.initials: DJ
authors.lastname: García-Gallegos
authors.forename: Eliseo
authors.initials: E
authors.lastname: Luis-López
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016638:Critical Illness; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications*; D055815:Young Adult
keywords: Critical illness; Hyperglycemia; Intensive care unit; Physiological stress; Prediabetes