title: Association study between the TP53 Rs1042522G/C polymorphism and susceptibility to systemic lupus erythematosus in a Chinese Han population.
abstract: Tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial. In this study, for the first time, we evaluated its association with SLE in a Chinese Han population. This case-control study enrolled 1470 SLE patients and 2283 healthy controls. The genotyping of TP53 rs1042522 polymorphism was determined by Sequenom Mass ARRAY technology. Statistical analysis was conducted by Chi-square test (χ2test). Odds ratio (OR) with 95% confidence interval (CI) was calculated using unconditional logistic regression with adjusting age and sex. Allele and genotype frequencies of TP53 rs1042522G/C polymorphism showed statistically significant difference between the SLE patients and the normal controls (C vs. G: OR = 0.89, 95% CI 0.89-0.97, p = 0.01; (GC + CC) vs. GG using recessive model: OR = 0.84, 95% CI 0.73-0.96, p = 0.01; GC vs. GG using co-dominant model: OR = 0.86, 95% CI 0.74-0.99, p = 0.04; CC vs. GG using co-dominant model: OR = 0.80, 95% CI 0.66-0.96, p = 0.02; GC vs. GG using co-dominant model: OR = 0.86, 95% CI 0.74-0.99, p = 0.02). In addition, there was weak association between discoid rash and distribution of TP53 rs1042522G/C polymorphism in SLE patients (C vs. G: OR = 1.25, 95% CI 1.00-1.55, p = 0.04; CC vs. GG using co-dominant model: OR = 1.54, 95% CI 1.10-2.36, p = 0.04). Our finding suggests a significant relationship between the TP53 rs1042522G/C polymorphism and SLE. TP53 rs1042522G/C polymorphism would be promising as an indicator of SLE as well as the therapeutic target if its functions and mechanisms could be further investigated.
authors.affiliation: Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, 103 Meishan Road Hefei, Anhui, 230038, China.
authors.forename: Jie
authors.identifier: http://orcid.org/0000-0001-5583-5062
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, 103 Meishan Road Hefei, Anhui, 230038, China.
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Zhu
authors.affiliation: Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, 103 Meishan Road Hefei, Anhui, 230038, China.
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, 103 Meishan Road Hefei, Anhui, 230038, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, 103 Meishan Road Hefei, Anhui, 230038, China.
authors.forename: Ming-Rui
authors.initials: MR
authors.lastname: Wang
authors.affiliation: Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, 103 Meishan Road Hefei, Anhui, 230038, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.affiliation: Department of Information, The Second Hospital of Anhui Medical University, 678 Furong Road Hefei, Anhui, 230601, China. 21655673@qq.com.
authors.forename: Yu-Wei
authors.identifier: http://orcid.org/0000-0002-3461-2238
authors.initials: YW
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D055815:Young Adult
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: Case-control study; P53; Systemic lupus erythematosus; TP53 rs1042522G/C polymorphism