title: Cerebrospinal fluid markers detect Alzheimer's disease in nonamnestic dementia.
abstract: BACKGROUND
  The accuracy of cerebrospinal fluid (CSF) biomarkers for detecting Alzheimer's disease (AD) pathology has not been fully validated in autopsied nonamnestic dementias.
  
  
  METHODS
  We retrospectively evaluated CSF amyloid β 1-42, phosphorylated-tau, and amyloid-tau index as predictors of Alzheimer pathology in patients with primary progressive aphasia, frontotemporal dementia, and progressive supranuclear palsy.
  
  
  RESULTS
  Nineteen nonamnestic autopsied cases with relevant CSF values were included. At autopsy, nine had AD and 10 had non-AD pathologies. All six patients whose combined CSF phosphorylated-tau and amyloid β levels were "consistent with AD" had postmortem Alzheimer pathology. The two patients whose biomarker values were "not consistent with AD" had non-AD pathologies. The CSF values of the remaining eight non-AD cases were in conflicting or borderline ranges.
  
  
  CONCLUSIONS
  CSF biomarkers reliably identified Alzheimer pathology in nonamnestic dementias and may be useful as a screening measure for inclusion of nonamnestic cases into Alzheimer's trials.
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: c.oboudiyat@gmail.com.
authors.forename: Carly
authors.initials: C
authors.lastname: Oboudiyat
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Tamar
authors.initials: T
authors.lastname: Gefen
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Eleni
authors.initials: E
authors.lastname: Varelas
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Weintraub
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Rogalski
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Eileen H
authors.initials: EH
authors.lastname: Bigio
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: M-Marsel
authors.initials: MM
authors.lastname: Mesulam
mesh_terms: D000544:Alzheimer Disease / Q000145:classification* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D018888:Aphasia, Primary Progressive; D001344:Autopsy; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D012189:Retrospective Studies; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; D016875:tau Proteins
keywords: Atypical Alzheimer's disease; Behavioral variant frontotemporal dementia; Neuropathology; Primary progressive aphasia; Progressive supranuclear palsy