title: Association of medial prefrontal resting state functional connectivity and metacognitive capacity in early phase psychosis.
abstract: Metacognition refers to a range of cognitive processes that allow one to form complex ideas of self and others and to use this information to navigate psychosocial challenges. Several studies in both early-phase and prolonged schizophrenia have demonstrated not only that significant deficits in metacognitive ability are present, but importantly that they are associated with significant functional impairment and decreased quality of life. In spite of the importance of metacognitive impairment in schizophrenia, relatively little is known about the biological substrates that may contribute to this dysfunction. In this study, we examined the relationship between resting state functional connectivity of the medial prefrontal cortex (mPFC), a structure shown in prior voxel-based morphometry studies to be associated with metacognition, with metacognitive function in an early-phase psychosis cohort (n=18). Analyses revealed a positive association of resting state functional connectivity between the mPFC and precuneus and posterior cingulate structures and metacognitive ability. These results provide evidence of disrupted resting state connectivity in structures relevant to metacognitive dysfunction in early-phase psychosis, which may have implications for pathophysiological models of complex cognitive deficits in this illness.
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., Suite 4800, Indianapolis, IN 46202, USA; Prevention and Recovery Center for Early Psychosis, Eskenazi Health Midtown Community Mental Health Center, 720 Eskenazi Avenue, Outpatient Care Center, Lower Level, Indianapolis, IN 46202, USA; Larue D. Carter Memorial Hospital, IU Psychotic Disorders Program, 2601 Cold Spring Rd., Research Unit (8-2048), Indianapolis, IN 46222, USA. Electronic address: mmfranci@iupui.edu.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Francis
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., Suite 4800, Indianapolis, IN 46202, USA. Electronic address: thummer@iupui.edu.
authors.forename: Tom A
authors.initials: TA
authors.lastname: Hummer
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., Suite 4800, Indianapolis, IN 46202, USA; Prevention and Recovery Center for Early Psychosis, Eskenazi Health Midtown Community Mental Health Center, 720 Eskenazi Avenue, Outpatient Care Center, Lower Level, Indianapolis, IN 46202, USA; Larue D. Carter Memorial Hospital, IU Psychotic Disorders Program, 2601 Cold Spring Rd., Research Unit (8-2048), Indianapolis, IN 46222, USA. Electronic address: blleonha@iupui.edu.
authors.forename: Bethany L
authors.initials: BL
authors.lastname: Leonhardt
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., Suite 4800, Indianapolis, IN 46202, USA; Prevention and Recovery Center for Early Psychosis, Eskenazi Health Midtown Community Mental Health Center, 720 Eskenazi Avenue, Outpatient Care Center, Lower Level, Indianapolis, IN 46202, USA; Larue D. Carter Memorial Hospital, IU Psychotic Disorders Program, 2601 Cold Spring Rd., Research Unit (8-2048), Indianapolis, IN 46222, USA. Electronic address: jvohs@iupui.edu.
authors.forename: Jenifer L
authors.initials: JL
authors.lastname: Vohs
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., Suite 4800, Indianapolis, IN 46202, USA. Electronic address: mgyung@iupui.edu.
authors.forename: Matt G
authors.initials: MG
authors.lastname: Yung
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., Suite 4800, Indianapolis, IN 46202, USA; Prevention and Recovery Center for Early Psychosis, Eskenazi Health Midtown Community Mental Health Center, 720 Eskenazi Avenue, Outpatient Care Center, Lower Level, Indianapolis, IN 46202, USA; Larue D. Carter Memorial Hospital, IU Psychotic Disorders Program, 2601 Cold Spring Rd., Research Unit (8-2048), Indianapolis, IN 46222, USA. Electronic address: nmehdiyo@iupui.edu.
authors.forename: Nicole F
authors.initials: NF
authors.lastname: Mehdiyoun
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, Roudebush VA Medical Hospital, 1481 W 10th St., Indianapolis, IN 46202, USA. Electronic address: plysaker@iupui.edu.
authors.forename: Paul H
authors.initials: PH
authors.lastname: Lysaker
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., Suite 4800, Indianapolis, IN 46202, USA; Prevention and Recovery Center for Early Psychosis, Eskenazi Health Midtown Community Mental Health Center, 720 Eskenazi Avenue, Outpatient Care Center, Lower Level, Indianapolis, IN 46202, USA; Larue D. Carter Memorial Hospital, IU Psychotic Disorders Program, 2601 Cold Spring Rd., Research Unit (8-2048), Indianapolis, IN 46222, USA. Electronic address: abreier@iupui.edu.
authors.forename: Alan
authors.initials: A
authors.lastname: Breier
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000067489:Metacognition / Q000502:physiology*; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055815:Young Adult
keywords: Early-phase psychosis; Metacognition; Resting state fMRI