title: Altered spontaneous brain activity in adolescent boys with pure conduct disorder revealed by regional homogeneity analysis.
abstract: Functional magnetic resonance imaging (fMRI) studies have revealed abnormal neural activity in several brain regions of adolescents with conduct disorder (CD) performing various tasks. However, little is known about the spontaneous neural activity in people with CD in a resting state. The aims of this study were to investigate CD-associated regional activity abnormalities and to explore the relationship between behavioral impulsivity and regional activity abnormalities. Resting-state fMRI (rs-fMRI) scans were administered to 28 adolescents with CD and 28 age-, gender-, and IQ-matched healthy controls (HCs). The rs-fMRI data were subjected to regional homogeneity (ReHo) analysis. ReHo can demonstrate the temporal synchrony of regional blood oxygen level-dependent signals and reflect the coordination of local neuronal activity facilitating similar goals or representations. Compared to HCs, the CD group showed increased ReHo bilaterally in the insula as well as decreased ReHo in the right inferior parietal lobule, right middle temporal gyrus and right fusiform gyrus, left anterior cerebellum anterior, and right posterior cerebellum. In the CD group, mean ReHo values in the left and the right insula correlated positively with Barratt Impulsivity Scale (BIS) total scores. The results suggest that CD is associated with abnormal intrinsic brain activity, mainly in the cerebellum and temporal-parietal-limbic cortices, regions that are related to emotional and cognitive processing. BIS scores in adolescents with CD may reflect severity of abnormal neuronal synchronization in the insula.
authors.affiliation: Medical Psychological Institute, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Medical Psychological Institute, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Xiaocui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Medical Psychological Institute, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Daifeng
authors.initials: D
authors.lastname: Dong
authors.affiliation: Medical Psychological Institute, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Medical Psychological Institute, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China. shuqiaoyao@163.com.|National Technology Institute of Psychiatry, Central South University, Changsha, Hunan, People's Republic of China. shuqiaoyao@163.com.|Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, People's Republic of China. shuqiaoyao@163.com.
authors.forename: Shuqiao
authors.initials: S
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D019955:Conduct Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male
keywords: Barratt Impulsivity Scale; Insula; Intrinsic brain activity; Resting-state functional magnetic resonance imaging