title: Incidence of Malignancy and Myoma Variants at Surgery for Presumed Benign Symptomatic Myomas.
abstract: STUDY OBJECTIVE: To estimate the incidence of leiomyosarcoma; other uterine pathologies; and the frequency of use of morcellation, both mechanical and manual in laparoscopic, vaginal, and laparotomy operative routes in women undergoing hysterectomy or myomectomy for benign gynecologic indications when myomas were present.
  
  
  
  A retrospective study (Canadian Task Force classification II-3).
  
  
  
  The Royal Women's Hospital, Melbourne, Australia.
  
  
  
  All hysterectomies and myomectomies (any route) for a 10-year period from January 1, 2004, to December 31, 2013, for presumed benign gynecologic indications.
  
  
  
  Hysterectomy or myomectomy, any route.
  
  
  
  From January 1, 2004, to December 31, 2013, a total of 2790 hysterectomies and myomectomies were performed for presumed benign disease. Myomas were present in 1878 cases. There were no cases of leiomyosarcoma identified, giving an incidence of 0% (95% confidence interval, 0%-0.20%). There were 73 (4%) cases of benign variants, of which 2 (3%) displayed metastatic behavior. There were 11 cases of unexpected malignancy (0.6%).
  
  
  
  There were no confirmed cases of leiomyosarcoma over the 10-year period in women requiring surgery for presumed benign disease in the presence of myomas. There was a low but significant rate of unexpected gynecologic malignancy and a higher than expected rate of clinically significant adverse outcomes with manually morcellated cellular myoma variants.
authors.affiliation: The Royal Hospital for Women, Melbourne, Victoria, Australia. Electronic address: mcebola@hotmail.com.
authors.forename: Monique Ramos
authors.initials: MR
authors.lastname: Damasco
authors.affiliation: The Royal Hospital for Women, Melbourne, Victoria, Australia.
authors.forename: Pui-Wan Kiri
authors.initials: PK
authors.lastname: Chan
authors.affiliation: The Royal Hospital for Women, Melbourne, Victoria, Australia.
authors.forename: Marnie
authors.initials: M
authors.lastname: Slonim
authors.affiliation: The Royal Hospital for Women, Melbourne, Victoria, Australia; The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Woun-Eng Catarina
authors.initials: WC
authors.lastname: Ang
authors.affiliation: The Royal Hospital for Women, Melbourne, Victoria, Australia; The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Martin Graham
authors.initials: MG
authors.lastname: Healey
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015994:Incidence; D010535:Laparoscopy; D007813:Laparotomy; D007889:Leiomyoma / Q000601:surgery*; D007890:Leiomyosarcoma / Q000453:epidemiology; D008875:Middle Aged; D000069577:Morcellation / Q000009:adverse effects / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D063186:Uterine Myomectomy; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000601:surgery*
keywords: Hysterectomy; Leiomyosarcoma; Morcellation; Myomectomy