title: Effect of nebulized budesonide on decreasing the recurrence of allergic fungal rhinosinusitis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical efficacy and the effects on decreasing the recurrence of AFRS (allergic fungal rhinosinusitis) of a budesonide inhalation suspension delivered via transnasal nebulization to patients following endoscopic sinus surgery.
  
  
  METHODS
  Thirty-five patients were recruited into this study. Final diagnoses were reached using Bent and Kuhn's criteria. The eligible patients were randomly divided into two groups: the budesonide transnasal nebulization group (group A) and the topical nasal steroids group (group B). Nasal symptoms, Lund-Mackay scores, and Kupferberg grades were evaluated before surgery, after surgery and during the follow-up to assess the effects of these two approaches.
  
  
  RESULTS
  A total of 30 patients with AFRS who were eligible were included in the study. Four of the 15 patients in group B (26.67%) developed recurrent disease, whereas no patients in group A developed recurrent disease. This difference was statistically significant (p=0.032).
  
  
  CONCLUSIONS
  Nebulized budesonide is an effective and safe treatment for patients with AFRS following endoscopic sinus surgery, as evidenced by the reduced recurrence rate observed in the budesonide transnasal nebulization group relative to the topical nasal steroids group.
authors.affiliation: Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, 83 Fenyang Road, Shanghai 200031, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, 83 Fenyang Road, Shanghai 200031, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Duan
authors.affiliation: Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, 83 Fenyang Road, Shanghai 200031, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, 83 Fenyang Road, Shanghai 200031, China. Electronic address: hongmengyush@163.com.
authors.forename: Hongmeng
authors.initials: H
authors.lastname: Yu
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D019819:Budesonide / Q000008:administration & dosage*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D012008:Recurrence; D065631:Rhinitis, Allergic / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D019819:Budesonide
keywords: Allergic fungal rhinosinusitis; Nebulized budesonide