title: qnrE1, a Member of a New Family of Plasmid-Located Quinolone Resistance Genes, Originated from the Chromosome of Enterobacter Species.
abstract: qnrE1, found in a clinicalKlebsiella pneumoniaeisolate, was undetectable by PCR assays used for the sixqnrfamilies.qnrE1was located on a conjugative plasmid (ca. 185 kb) and differed fromqnrBalleles by 25%. Phylogenetic reconstructions ofqnrgenes and proteins and analysis of theqnrE1surroundings showed that this gene belongs to a newqnrfamily and was likely mobilized by ISEcp1from the chromosome ofEnterobacterspp. to plasmids ofK. pneumoniae.
authors.affiliation: Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Albornoz
authors.affiliation: Public Health Ontario Laboratory, Toronto, Ontario, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tijet
authors.affiliation: Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Denise
authors.initials: D
authors.lastname: De Belder
authors.affiliation: Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Sonia
authors.initials: S
authors.lastname: Gomez
authors.affiliation: Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Florencia
authors.initials: F
authors.lastname: Martino
authors.affiliation: Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Corso
authors.affiliation: Public Health Ontario Laboratory, Toronto, Ontario, Canada.
authors.forename: Roberto G
authors.initials: RG
authors.lastname: Melano
authors.affiliation: Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Ciudad Autónoma de Buenos Aires, Argentina apetroni@anlis.gov.ar.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Petroni
mesh_terms: D000368:Aged; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D027081:DNA Gyrase / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005260:Female; D022761:Gene Transfer, Horizontal / Q000235:genetics; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C485385:Qnr protein, Klebsiella pneumoniae; D015363:Quinolones; D027081:DNA Gyrase
keywords: PMQR; qnr detection; qnrB; quinolone; resistance