title: HOXC10 suppresses browning of white adipose tissues.
abstract: Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here we show that HOXC10, a homeobox domain-containing transcription factor expressed in subcutaneous white adipose tissue, is a suppressor of genes involved in browning white adipose tissue. Ectopic expression of HOXC10 in adipocytes suppresses brown fat genes, whereas the depletion of HOXC10 in adipocytes and myoblasts increases the expression of brown fat genes. The protein level of HOXC10 inversely correlates with brown fat genes in subcutaneous white adipose tissue of cold-exposed mice. Expression of HOXC10 in mice suppresses cold-induced browning in subcutaneous white adipose tissue and abolishes the beneficial effect of cold exposure on glucose clearance. HOXC10 exerts its effect, at least in part, by suppressing PRDM16 expression. The results support that HOXC10 is a key negative regulator of the process of browning in white adipose tissue.
authors.affiliation: Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Ng
authors.affiliation: Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Shi-Xiong
authors.initials: SX
authors.lastname: Tan
authors.affiliation: Cardiovascular and Metabolic Disorder Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: Sook Yoong
authors.initials: SY
authors.lastname: Chia
authors.affiliation: Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Hwee Yim Angeline
authors.initials: HY
authors.lastname: Tan
authors.affiliation: Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Sin Yee
authors.initials: SY
authors.lastname: Gun
authors.affiliation: Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.|Cardiovascular and Metabolic Disorder Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.affiliation: Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Wanjin
authors.initials: W
authors.lastname: Hong
authors.affiliation: Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.|Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Weiping
authors.identifier: 0000-0002-5023-2104
authors.initials: W
authors.lastname: Han
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000502:physiology; D052436:Adipose Tissue, White / Q000502:physiology*; D000818:Animals; D002460:Cell Line; D003080:Cold Temperature; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D057809:HEK293 Cells; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D022722:Thermogenesis
chemical_list: D018398:Homeodomain Proteins; C076138:Hox 3.6 protein, mouse; D005947:Glucose