title: IL-8 -251A/T polymorphism contributes to coronary artery disease susceptibility in a Chinese population.
abstract: Interleukin-8 (IL-8) is a mediator of inflammation and plays an important role in regulating immune responses. To date, several studies have tested the association between IL-8 gene polymorphisms and development of coronary artery disease (CAD), but their results have proved to be inconsistent. We conducted an investigation to assess the relationship between the IL-8 -251A/T (rs4073) sequence variant and CAD in a Chinese population. Between April 2013 and January 2015, 217 patients with coronary angiography-confirmed CAD were enrolled in our study, along with 245 control subjects. IL-8 -251A/T genotyping was performed using a polymerase chain reaction-restriction fragment length polymorphism assay. A chi-square test revealed that IL-8 -251A/T genotype distributions significantly differed between CAD patients and control subjects (chi-square = 8.29, P < 0.02). Moreover, multiple-logistic regression analysis showed that individuals carrying TA [odds ratio (OR) = 1.59, 95% confidence interval (CI) = 1.01-2.57] and AA (OR = 2.06, 95%CI = 1.21-3.52) genotypes were at increased risk of CAD compared to those with the TT genotype. Under dominant (OR = 1.75, 95%CI = 1.13-2.73) and recessive (OR = 1.54, 95%CI = 1.02-2.37) genetic models, the IL-8 -251A/T polymorphism also significantly correlated with CAD. In conclusion, our results suggest that this variant is an independent risk factor for CAD development under codominant, dominant, and recessive models.
authors.affiliation: Department of Cardiovascular Medicine, People's Hospital of Linyi City, Linyi, China.
authors.forename: R J
authors.initials: RJ
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Medicine, People's Hospital of Linyi City, Linyi, China.
authors.forename: X D
authors.initials: XD
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Medicine, People's Hospital of Linyi City, Linyi, China zhangsw_zsw@126.com.
authors.forename: S W
authors.initials: SW
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Medicine, People's Hospital of Linyi City, Linyi, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Internal Medicine, Zhengzhou People's Hospital, Zhengzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Wu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8