title: Vitamin K status in cystic fibrosis patients with liver cirrhosis.
abstract: The available data on the influence of liver cirrhosis on vitamin K status in CF patients is scarce. Therefore, the aims of the present study were to assess the prevalence of vitamin K deficiency in cirrhotic CF subjects and to determine whether it correlates with liver cirrhosis. The study group comprised of 27 CF patients with and 63 without liver cirrhosis. Vitamin K status was assessed using prothrombin induced by vitamin K absence (PIVKA-II) and the percentage of undercarboxylated osteocalcin (u-OC). PIVKA-II concentrations were higher in cirrhotic than in non-cirrhotic CF patients (median [1st-3rd quartile]: 3.2ng/ml [1.0-10.0] vs. 1.3ng/ml [0.2-2.6], p=0.0029). However, the differences in u-OC percentages between the studied groups did not reach the level of significance (49.4% [7.0-73.8] vs. 8.0% [2.6-59.1], p=0.0501). Based on multiple linear regression analysis the dose of vitamin K and F508del mutation were potentially defined as determinants of vitamin K deficiency. Liver cirrhosis was not documented to be an independent risk factor. In CF patients with liver cirrhosis vitamin K deficiency is not only more frequent, but also more severe. However, not liver cirrhosis, but the presence of a F508del CFTR mutation constitutes an independent risk factor for vitamin K deficiency.
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Krzyżanowska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Sławomira
authors.initials: S
authors.lastname: Drzymała-Czyż
authors.affiliation: Department of Pulmonology and Cystic Fibrosis, Institute of Tuberculosis and Lung Diseases, Rabka-Zdroj, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pogorzelski
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Duś-Żuchowska
authors.affiliation: I Department of Lung Diseases, National Institute for Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Skorupa
authors.affiliation: Lviv Cystic Fibrosis Centre, Lviv Ukraine.
authors.forename: Lyudmyla
authors.initials: L
authors.lastname: Bober
authors.affiliation: The Specialist Centre for Medical Care of Mother and Child, Gdansk, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Sapiejka
authors.affiliation: Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Oralewska
authors.affiliation: Lviv Cystic Fibrosis Centre, Lviv Ukraine.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Rohovyk
authors.affiliation: Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Moczko
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Nowak
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wenska-Chyży
authors.affiliation: Allergology Outpatient Department, Provincial Hospital No. 2, Rzeszow, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Rachel
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: jarwalk@ump.edu.pl.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications* / Q000235:genetics; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D005260:Female; D006801:Humans; D016014:Linear Models; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D015675:Osteocalcin / Q000032:analysis; D011044:Poland; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D011516:Prothrombin; D012307:Risk Factors; D014812:Vitamin K / Q000008:administration & dosage*; D014813:Vitamin K Deficiency / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; C505032:CFTR protein, human; D011498:Protein Precursors; D015675:Osteocalcin; D014812:Vitamin K; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; C008208:acarboxyprothrombin; D011516:Prothrombin
keywords: Fat-soluble vitamin; Hepatology diseases; Prothrombin inducted by vitamin K absence-II; Undercarboxylated osteocalcin