title: Association between Resting Heart Rate and Inflammatory Markers (White Blood Cell Count and High-Sensitivity C-Reactive Protein) in Healthy Korean People.
abstract: BACKGROUND
  Inflammation is an important underlying mechanism in the pathogenesis of atherosclerosis, and an elevated resting heart rate underlies the process of atherosclerotic plaque formation. We hypothesized an association between resting heart rate and subclinical inflammation.
  
  
  METHODS
  Resting heart rate was recorded at baseline in the KoGES-ARIRANG (Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population) cohort study, and was then divided into quartiles. Subclinical inflammation was measured by white blood cell count and high-sensitivity C-reactive protein. We used progressively adjusted regression models with terms for muscle mass, body fat proportion, and adiponectin in the fully adjusted models. We examined inflammatory markers as both continuous and categorical variables, using the clinical cut point of the highest quartile of white blood cell count (≥7,900/mm3) and ≥3 mg/dL for high-sensitivity C-reactive protein.
  
  
  RESULTS
  Participants had a mean age of 56.3±8.1 years and a mean resting heart rate of 71.4±10.7 beats/min; 39.1% were men. In a fully adjusted model, an increased resting heart rate was significantly associated with a higher white blood cell count and higher levels of high-sensitivity C-reactive protein in both continuous (P for trend <0.001) and categorical (P for trend <0.001) models.
  
  
  CONCLUSIONS
  An increased resting heart rate is associated with a higher level of subclinical inflammation among healthy Korean people.
authors.affiliation: Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Woo-Chul
authors.initials: WC
authors.lastname: Park
authors.affiliation: Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Inho
authors.initials: I
authors.lastname: Seo
authors.affiliation: Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Shin-Hye
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Yong-Jae
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Song Vogue
authors.initials: SV
authors.lastname: Ahn
keywords: Atherosclerosis; C-Reactive Protein; Heart Rate; Inflammation; Leukocytes