title: Glutathione-responsive paclitaxel dimer nanovesicles with high drug content.
abstract: Paclitaxel dimer-based nanovesicles, with an ultrahigh drug content, have been prepared through a nanoprecipitation method. The as-formed nanovesicles exhibit improved paclitaxel solubility, prominent colloid stability, GSH-triggered disassembly, effective cellular uptake and comparable cytotoxicity to Taxol.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn and University of Science and Technology of China, Hefei 230026, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Pei
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn and University of Science and Technology of China, Hefei 230026, P. R. China.
authors.forename: Junli
authors.initials: J
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn.
authors.forename: Shi
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn.
authors.forename: Zhigang
authors.identifier: http://orcid.org/0000-0003-2974-1825
authors.initials: Z
authors.lastname: Xie
mesh_terms: D000818:Animals; D001692:Biological Transport; D002471:Cell Transformation, Neoplastic; D019281:Dimerization; D004337:Drug Carriers / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D013864:Thioglycolates / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D013864:Thioglycolates; C010518:thiodiacetic acid; D005978:Glutathione; D017239:Paclitaxel