title: Two Furanharzianones with 4/7/5/6/5 Ring System from Microbial Transformation of Harzianone.
abstract: Furanharzianones A and B (2 and 3), two new harziane-type diterpenoids with a tetrahydrofuran and unusual 4/7/5/6/5 ring system, were obtained from the microbial transformation of harzianone (1) by a bacterial strain Bacillus sp. IMM-006. The structures, including the stereochemistry, of the two new compounds were elucidated by extensive spectroscopic analysis. The absolute configuration of 2 was unambiguously determined by single-crystal X-ray diffraction. In addition, a plausible bioconversion pathway was proposed.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Jimei
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Ridao
authors.initials: R
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Jinlian
authors.initials: J
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Kebo
authors.initials: K
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Keping
authors.initials: K
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
authors.forename: Jungui
authors.identifier: 0000-0003-2989-9016
authors.initials: J
authors.lastname: Dai