title: Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection.
abstract: Cancer remains one of the leading causes of death worldwide. Biomedical imaging plays a crucial role in all phases of cancer management. Physicians often need to choose the ideal diagnostic imaging modality for each clinical presentation based on complex trade-offs among spatial resolution, sensitivity, contrast, access, cost, and safety. Magnetic particle imaging (MPI) is an emerging tracer imaging modality that detects superparamagnetic iron oxide (SPIO) nanoparticle tracer with high image contrast (zero tissue background signal), high sensitivity (200 nM Fe) with linear quantitation, and zero signal depth attenuation. MPI is also safe in that it uses safe, in some cases even clinically approved, tracers and no ionizing radiation. The superb contrast, sensitivity, safety, and ability to image anywhere in the body lends MPI great promise for cancer imaging. In this study, we show for the first time the use of MPI for in vivo cancer imaging with systemic tracer administration. Here, long circulating MPI-tailored SPIOs were created and administered intravenously in tumor bearing rats. The tumor was highlighted with tumor-to-background ratio of up to 50. The nanoparticle dynamics in the tumor was also well-appreciated, with initial wash-in on the tumor rim, peak uptake at 6 h, and eventual clearance beyond 48 h. Lastly, we demonstrate the quantitative nature of MPI through compartmental fitting in vivo.
authors.affiliation: Department of Bioengineering, University of California , Berkeley, California 94720, United States.
authors.forename: Elaine Y
authors.identifier: 0000-0001-7361-1804
authors.initials: EY
authors.lastname: Yu
authors.affiliation: Department of Bioengineering, University of California , Berkeley, California 94720, United States.
authors.forename: Mindy
authors.initials: M
authors.lastname: Bishop
authors.affiliation: Department of Bioengineering, University of California , Berkeley, California 94720, United States.
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Lodespin Labs LLC, Seattle, Washington 98103, United States.
authors.forename: R Matthew
authors.initials: RM
authors.lastname: Ferguson
authors.affiliation: Lodespin Labs LLC, Seattle, Washington 98103, United States.
authors.forename: Amit P
authors.initials: AP
authors.lastname: Khandhar
authors.affiliation: Lodespin Labs LLC, Seattle, Washington 98103, United States.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Kemp
authors.affiliation: Department of Materials Science, University of Washington , Seattle, Washington 98195, United States.
authors.forename: Kannan M
authors.initials: KM
authors.lastname: Krishnan
authors.affiliation: Magnetic Insight, Inc., Alameda, California 94501, United States.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Goodwill
authors.affiliation: Department of Bioengineering, University of California , Berkeley, California 94720, United States.|Department of Electrical Engineering and Computer Sciences, University of California , Berkeley, California 94720, United States.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Conolly
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000032:analysis*; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000032:analysis* / Q000648:ultrastructure; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging*; D051381:Rats
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles
keywords: Magnetic particle imaging; cancer imaging; medical imaging; nanoparticles