title: Aedes aegypti Larvicidal Sesquiterpene Alkaloids from Maytenus oblongata.
abstract: Four new sesquiterpene alkaloids (1-4) with a β-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.
authors.affiliation: CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
authors.forename: Seindé
authors.initials: S
authors.lastname: Touré
authors.affiliation: CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Nirma
authors.affiliation: CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane , 97300 Cayenne, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Falkowski
authors.affiliation: Unité de Contrôle et Adaptation des Vecteurs, Institut Pasteur de la Guyane , 97306 Cayenne, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dusfour
authors.affiliation: CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane , 97300 Cayenne, France.|UPRES-EA 4358 GlycoMev (Glycobiologie et Matrice Extracellulaire Végétale), Université de Rouen , 76821 Mont-Saint-Aignan, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Boulogne
authors.affiliation: CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane , 97300 Cayenne, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Jahn-Oyac
authors.affiliation: Unité Expérimentale d'Ecologie et d'Ecotoxicologie Aquatique, INRA-U3E , 35042 Rennes, France.
authors.forename: Maïra
authors.initials: M
authors.lastname: Coke
authors.affiliation: Unité Expérimentale d'Ecologie et d'Ecotoxicologie Aquatique, INRA-U3E , 35042 Rennes, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Azam
authors.affiliation: Unité de Contrôle et Adaptation des Vecteurs, Institut Pasteur de la Guyane , 97306 Cayenne, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Girod
authors.affiliation: CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Moriou
authors.affiliation: Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens (LEEISA), CNRS, Université de Guyane, IFREMER , 97300 Cayenne, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Odonne
authors.affiliation: CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.|Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Sorbonne Universités, UPMC Univ. Paris 06, CNRS , Observatoire Océanologique, 66650 Banyuls-sur-Mer, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Stien
authors.affiliation: CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane , 97300 Cayenne, France.
authors.forename: Emeline
authors.initials: E
authors.lastname: Houël
authors.affiliation: CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
authors.forename: Véronique
authors.identifier: 0000-0002-2954-0866
authors.initials: V
authors.lastname: Eparvier
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D005616:French Guiana; D007814:Larva / Q000187:drug effects*; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000621076:1,2-O-dibenzoyl-1,2-deacetyl-4-deoxyalatamine; C000621075:1-O-benzoyl-1-deacetyl-4-deoxyalatamine; C000621202:12,16-dihydroxyfriedelan-3-one; D000470:Alkaloids; D012717:Sesquiterpenes; D014315:Triterpenes