title: Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes.
abstract: We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA. PGRN-mediated inhibition of T lymphocyte proliferation, as well as the induction of iTregs, was completely reversed by a TGF-βinhibitor or a Treg inhibitor. PGRN induced TGF-βsecretion in the presence of PHA whereas it did not in the absence of PHA. Our findings indicate that PGRN suppresses T lymphocyte proliferation by enhancing the formation of iTregs from activated T lymphocytes in response to TGF-β.
authors.affiliation: Institute of Oral Biology, School of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
authors.forename: Kyu Hwan
authors.initials: KH
authors.lastname: Kwack
authors.affiliation: Institute of Oral Biology, School of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
authors.forename: Hyeon-Woo
authors.identifier: 0000-0002-7271-936X
authors.initials: HW
authors.lastname: Lee
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta