title: Emergent Role of Coronin-1a in Neuronal Signaling.
abstract: The Coronin family of proteins were first noted for their role in pathogen-host interactions and for modulating actin dynamics. Recently, however, Coronins have been found in a greater variety of cell types, and novel roles for the Coronins within the nervous system have been discovered. In the immune system, Coronin-1a enables Mycobacterium tuberculosis to evade lysosomal destruction. This activity appears to be analogous to protection of the NGF-TrkA signaling endosome during sympathetic nervous system development that is required for survival signaling. Similarly, others have implicated Coronin-1a in GPCR signaling during the formation of excitatory connections in the central nervous system. Its role in multiple signaling pathways suggests that it may influence cross talk between key pathways (TrkA, GPCRs) during neurodevelopment. Here, we review the role of Coronin-1a in neural development and function.
authors.affiliation: University of Virginia, Charlottesville, VA, United States.
authors.forename: M
authors.initials: M
authors.lastname: Martorella
authors.affiliation: University of Virginia, Charlottesville, VA, United States.
authors.forename: K
authors.initials: K
authors.lastname: Barford
authors.affiliation: University of Virginia, Charlottesville, VA, United States.
authors.forename: B
authors.initials: B
authors.lastname: Winkler
authors.affiliation: University of Virginia, Charlottesville, VA, United States. Electronic address: deppmann@virginia.edu.
authors.forename: C D
authors.initials: CD
authors.lastname: Deppmann
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D001678:Organelle Biogenesis; D015398:Signal Transduction; D009435:Synaptic Transmission
chemical_list: D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; C072061:coronin proteins
keywords: Coro1a; Coronin; NGF; Nerve growth factor; Neurodevelopment; Neurotrophins; Receptor tyrosine kinase; Sympathetic nervous system; TrkA