title: The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.
abstract: To verify the association between c.1083T>C polymorphism in the adenosine receptor A2Agene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from São Paulo, Brazil.
  
  
  
  This study was conducted in participants of the São Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from São Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007. Questionnaires, polysomnography, spectral analysis of sleep electroencephalogram, and c.1083T>C polymorphism genotyping were performed in this study.
  
  
  
  We found that caffeine consumption was positively correlated with sleep latency and α spectral power, as well as negatively correlated with percentage of N3 stage and δ spectral power in this stage. However, this association was identified only in T allele carriers and not in CC genotype.
  
  
  
  Our data support an important aspect of this polymorphism in ADORA2A gene, showing that the variant affects the association between caffeine consumption and objective sleep parameters in a large population-based cohort.
  
  
  
  Name: Epidemiology of sleep disturbances among adult population of the Sao Paulo City. URL: http://www.clinicaltrials.gov/ct2/show/NCT00596713?term = NCT00596713&rank = 1. Number: NCT00596713.
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Rafael Almeida
authors.initials: RA
authors.lastname: Nunes
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: mazzottidr@gmail.com.
authors.forename: Diego Robles
authors.initials: DR
authors.lastname: Mazzotti
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Hirotsu
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Andersen
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Lia
authors.initials: L
authors.lastname: Bittencourt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D012890:Sleep / Q000187:drug effects* / Q000235:genetics*; D055815:Young Adult
chemical_list: C000627179:ADORA2A protein, human; D000697:Central Nervous System Stimulants; D043705:Receptor, Adenosine A2A; D002110:Caffeine
keywords: Adenosine receptor; Caffeine intake; Polymorphism; Sleep