title: Quality-by-Design: Multivariate Model for Multicomponent Quantification in Refining Process of Honey.
abstract: OBJECTIVE
  A method for rapid analysis of the refining process of honey was developed based on near-infrared (NIR) spectroscopy.
  
  
  METHODS
  Partial least square calibration models were built for the four components after the selection of the optimal spectral pretreatment method and latent factors.
  
  
  RESULTS
  The models covered the samples of different temperatures and time points, therefore the models were robust and universal.
  
  
  CONCLUSIONS
  These results highlighted that the NIR technology could extract the information of critical process and provide essential process knowledge of the honey refining process.
  
  
  CONCLUSIONS
  A method for rapid analysis of the refining process of honey was developed based on near-infrared (NIR) spectroscopy.Abbreviation used:NIR: Near-infrared; 5-HMF: 5-hydroxymethylfurfural; RMSEP: Root mean square error of prediction; R: correlation coefficients; PRESS: prediction residual error-sum squares; TCM: Traditional Chinese medicine; HPLC: High-performance liquid chromatography; HPLC-DAD: HPLC-diode array detector; PLS: Partial least square; MSC: multiplicative scatter correction; RMSECV: Root mean square error of cross validation; RPD: Residual predictive deviation; 1D: 1storder derivative; SG: Savitzky-Golay smooth; 2D: 2ndorder derivative.
authors.affiliation: Department of Science and Technology Development of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Science and Technology Development of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Science and Technology Development of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Science and Technology Development of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Science and Technology Development of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Science and Technology Development of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Science and Technology Development of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
authors.forename: Yanjiang
authors.initials: Y
authors.lastname: Qiao
keywords: Honey; near-infrared; partial least; rapid analysis; refining process; squares