title: Snail and kidney fibrosis.
abstract: Snail family zinc finger 1 (SNAI1) is a transcription factor expressed during renal embryogenesis, and re-expressed in various settings of acute kidney injury (AKI). Subjected to tight regulation, SNAI1 controls major biological processes responsible for renal fibrogenesis, including mesenchymal reprogramming of tubular epithelial cells, shutdown of fatty acid metabolism, cell cycle arrest and inflammation of the microenvironment surrounding tubular epithelial cells. The present review describes in detail the interactions of SNAI1 with AKI-associated signalling pathways. We also discuss how this central factor has been iteratively (and promisingly) targeted in a number of animal models in order to prevent or slow down renal fibrogenesis.
authors.affiliation: French National Institute of Health and Medical Research (INSERM), UMR_S1155, Remodeling and Repair of Renal Tissue, Hôpital Tenon, Paris, France.
authors.forename: Noémie
authors.initials: N
authors.lastname: Simon-Tillaux
authors.affiliation: French National Institute of Health and Medical Research (INSERM), UMR_S1155, Remodeling and Repair of Renal Tissue, Hôpital Tenon, Paris, France.|Sorbonne Universités, UPMC Paris 06, UMR S_1155, Paris, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Hertig
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology*; D000071250:Snail Family Transcription Factors / Q000378:metabolism*
chemical_list: D000071250:Snail Family Transcription Factors
keywords: acute kidney injury; epithelium; fibroblasts; fibrosis; SNAIL