title: Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation.
abstract: Low-Frequency Oscillations (LFO) in the range of 7-9 Hz, or theta rhythm, has been recorded in rodents ambulating in the real world. However, intra-hippocampus EEG recordings during virtual navigation in humans have consistently reported LFO that appear to predominate around 3-4 Hz. Here we report clear evidence of 7-9 Hz rhythmicity in raw intra-hippocampus EEG traces during real as well as virtual movement. Oscillations typically occur at a lower frequency in virtual than real world navigation. This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual.
authors.affiliation: Douglas Institute, Department of Psychiatry, McGill University, 6875 boulevard LaSalle, Verdun, Quebec, Canada H4H 1R3.
authors.forename: Véronique D
authors.initials: VD
authors.lastname: Bohbot
authors.affiliation: Neuroscience Graduate Group, University of California, Davis, 1 Shields Avenue, Davis, California 95616, USA.
authors.forename: Milagros S
authors.initials: MS
authors.lastname: Copara
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4.
authors.forename: Jean
authors.initials: J
authors.lastname: Gotman
authors.affiliation: Neuroscience Graduate Group, University of California, Davis, 1 Shields Avenue, Davis, California 95616, USA.|Center for Neuroscience, University of California, Davis, 1 Shields Avenue, Davis, California 95618, USA.|Department of Psychology, University of California, Davis, 1 Shields Avenue, Davis, California 95618, USA.
authors.forename: Arne D
authors.initials: AD
authors.lastname: Ekstrom
mesh_terms: D000293:Adolescent; D000328:Adult; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D004594:Electrophysiology; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D000070587:Mental Navigation Tests / Q000379:methods*; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D010507:Periodicity; D065852:Spatial Memory; D065854:Spatial Navigation / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology; D013826:Theta Rhythm / Q000502:physiology*; D014584:User-Computer Interface; D055815:Young Adult