title: The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy.
abstract: OBJECTIVE
  To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs).
  
  
  METHODS
  A total of 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of visually assessed RS-fMRI, MRI, magnetic resonance spectroscopy (MRS), video electroencephalography (VEEG), and positron-emission tomography computed tomography (PET-CT) in EZ localization were evaluated to assess their diagnostic abilities. ReHo, ALFF, and fALFF were also compared for their diagnostic values.
  
  
  RESULTS
  RS-fMRI showed comparable sensitivity to PET (83.3%) and specificity to VEEG (66.7%), respectively, for EZ localization in patients with focal epilepsy. There were no significant differences between RS-fMRI and the other localization techniques in terms of sensitivity, specificity, PPV, and NPV. The sensitivities of ReHo, ALFF, and fALFF were 69.4%, 52.8%, and 38.9%, respectively, and for specificities of 66.7%, 83.3%, and 66.7%, respectively. There were no significant differences among ReHo, ALFF, and fALFF, except that ReHo was more sensitive than fALFF.
  
  
  CONCLUSIONS
  RS-fMRI may be an efficient tool for detecting EZs in focal epilepsy patients.
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Chen
authors.affiliation: First Central Clinical College, Tianjin Medical University, Tianjin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: An
authors.affiliation: Radiology Department, Tianjin First Central Hospital, Tianjin, China.
authors.forename: Bofeng
authors.initials: B
authors.lastname: Zhao
authors.affiliation: First Central Clinical College, Tianjin Medical University, Tianjin, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Clinical PET-CT Center, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.affiliation: Radiology Department, Tianjin First Central Hospital, Tianjin, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ni
authors.affiliation: Radiology Department, Tianjin First Central Hospital, Tianjin, China.
authors.forename: Jianzhong
authors.identifier: http://orcid.org/0000-0002-6821-1686
authors.initials: J
authors.lastname: Yin
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D012680:Sensitivity and Specificity; D055815:Young Adult