title: [Role of dipeptidyl peptidase-4 and its inhibitor in the respiratory diseases].
abstract: Dipeptidyl peptidase-4 (DPP-4) is known as a highly conserved type II transmembraneous glycoprotein widely distributed in a variety of tissues and cells, and expressed in the peripheral blood as a soluble form. It has been reported that DPP4 play a distinct role in the physiological and pathological processes, such as immune regulation, inflammatory reaction, cell adhesion, and cell apoptosis. DPP4 inhibitor showes an incredible effect on the control of blood glucose and it is thought as a newly-developed drug for diabetes, especially in regulation of post-prandial glycemia. It has been reported that DPP4 plays a potential role in many respiratory diseases, especially in the pathogenesis of asthma.
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Guilin Medical University;. Institute of Respiratory Diseases, Guilin Medical University; Key Laboratory of Respiratory Diseases of  Colleges and Universities Affiliated Education Department of Guangxi Zhuang Autonomous Region, Guilin Guangxi 541001, China.
authors.forename: Yabing
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Guilin Medical University;. Institute of Respiratory Diseases, Guilin Medical University; Key Laboratory of Respiratory Diseases of  Colleges and Universities Affiliated Education Department of Guangxi Zhuang Autonomous Region, Guilin Guangxi 541001, China.
authors.forename: Libing
authors.initials: L
authors.lastname: Ma
mesh_terms: D017209:Apoptosis / Q000502:physiology; D001249:Asthma / Q000209:etiology / Q000503:physiopathology; D001786:Blood Glucose / Q000187:drug effects; D002448:Cell Adhesion / Q000502:physiology; D018819:Dipeptidyl Peptidase 4 / Q000502:physiology*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents; D007249:Inflammation / Q000503:physiopathology; D012140:Respiratory Tract Diseases / Q000209:etiology / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4