title: Incidence and survival of end-stage kidney disease due to polycystic kidney disease in Australia and New Zealand (1963-2014).
abstract: The aim of this study was to determine whether the incidence and survival of patients with end-stage kidney disease (ESKD) due to polycystic kidney disease (PKD) has changed in Australia and New Zealand.
  
  
  
  Data for all PKD patients who developed ESKD and commenced renal replacement therapy (RRT) was assessed using the Australia and New Zealand Dialysis and Transplant Registry from 1963 to 2014.
  
  
  
  A total 4678 patients with ESKD due to PKD received RRT during the study period. The incidence rate of ESKD (per million population per year) due to PKD rose by 3.2-fold (1970-2010), but the percentage increase between each decade decreased (54.4, 43.8, 25.6 and 6.57%). The median age of onset of new patients developing ESKD has been stable since 1990. Haemodialysis was the most common initial mode of RRT (between 62 and 76% of patients) whereas 24-29% received peritoneal dialysis. The 5-year survival rate of PKD patients on RRT (censored for transplantation and adjusted for age) improved from 26 to 84%, with the percentage increase between each successive time period being 123, 7, 21, 19 and 7.4%. The percentage of deaths on RRT due to cerebrovascular disease declined from 15 to 6%.
  
  
  
  The incidence and age of onset of ESKD due to PKD has remained unchanged in the modern era though patient survival on RRT has continued to improve. These data suggest that the development and implementation of disease-specific treatments prior to RRT is needed to effectively diminish the incidence of ESKD due to PKD.
authors.affiliation: Department of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.|Department of Nephrology, Prince of Wales Hospital, Randwick, Sydney, Australia.|Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
authors.forename: Mangalee R
authors.initials: MR
authors.lastname: Fernando
authors.affiliation: ANZDATA Registry, Adelaide, Australia.|Department of Medicine, The University of Adelaide, Adelaide, Australia.
authors.forename: Hannah
authors.initials: H
authors.lastname: Dent
authors.affiliation: ANZDATA Registry, Adelaide, Australia.|Department of Medicine, The University of Adelaide, Adelaide, Australia.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: McDonald
authors.affiliation: Department of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia. g.rangan@sydney.edu.au.|Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, PO Box 412, 176 Hawkesbury Road, Westmead, Sydney, NSW, 2145, Australia. g.rangan@sydney.edu.au.
authors.forename: Gopala K
authors.initials: GK
authors.lastname: Rangan
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001315:Australia / Q000453:epidemiology; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000401:mortality; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D016030:Kidney Transplantation; D008875:Middle Aged; D009520:New Zealand / Q000453:epidemiology; D010530:Peritoneal Dialysis; D007690:Polycystic Kidney Diseases / Q000150:complications* / Q000401:mortality / Q000628:therapy; D012042:Registries; D006435:Renal Dialysis; D016019:Survival Analysis; D015996:Survival Rate
keywords: End-stage kidney disease; Polycystic kidney disease