title: Mitochondrial dysfunction and ovarian aging.
abstract: Mitochondria are double-membrane-bound organelles that are responsible for the generation of most of the cell's energy. Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in particular. Recent studies exploited this association by studying mitochondrial DNA (mtDNA) copy number as a potential biomarker of embryo viability and the use of mitochondrial nutrients and autologous mitochondrial transfer as a potential treatment for poor ovarian function and response.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Tianren
authors.identifier: 0000-0002-9761-8434
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Zongliang
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Emre
authors.initials: E
authors.lastname: Seli
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D010053:Ovary / Q000502:physiology*
keywords: aging; mitochondria; ovary; reproduction