title: Importin-11 keeps PTEN safe from harm.
abstract: In this issue, Chen et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, becauseIpo11mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.
authors.affiliation: Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, EH14 4AS, Scotland, UK n.r.leslie@hw.ac.uk.
authors.forename: Nick R
authors.identifier: 0000-0001-5131-0541
authors.initials: NR
authors.lastname: Leslie
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D028961:beta Karyopherins / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins; D028961:beta Karyopherins; D051059:PTEN Phosphohydrolase