title: [Corneal cell therapy-an overview].
abstract: In recent years, the cultivation and expansion of primary corneal cells has made significant progress. The transplantation of cultured limbal epithelial cells represents a successful and established treatment of the ocular surface. Cultivated corneal endothelial cells are undergoing a clinical trial in Japan. Stromal keratocytes can now be expanded in vitro. A wide range of stem cell sources is being tested in vitro and animal models for their possible application in corneal cell therapy. This article gives an overview of recent advancements and prevailing limitations for the use of different cell sources in the therapy of corneal disease.
authors.affiliation: Klinik für Augenheilkunde, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland. mfuest@ukaachen.de.|Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapur, Singapur. mfuest@ukaachen.de.
authors.forename: M
authors.initials: M
authors.lastname: Fuest
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapur, Singapur.|Eye-ACP, Duke-NUS Graduate Medical School, Singapur, Singapur.
authors.forename: G Hin-Fai
authors.initials: GH
authors.lastname: Yam
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapur, Singapur.|Eye-ACP, Duke-NUS Graduate Medical School, Singapur, Singapur.
authors.forename: G Swee-Lim
authors.initials: GS
authors.lastname: Peh
authors.affiliation: Klinik für Augenheilkunde, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Walter
authors.affiliation: Klinik für Augenheilkunde, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Plange
authors.affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapur, Singapur.|Eye-ACP, Duke-NUS Graduate Medical School, Singapur, Singapur.|Singapore National Eye Centre, Singapur, Singapur.|School of Material Science and Engineering, Nanyang Technological University, Singapur, Singapur.
authors.forename: J S
authors.initials: JS
authors.lastname: Mehta
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002478:Cells, Cultured; D060527:Corneal Keratocytes / Q000637:transplantation; D003319:Corneal Stroma / Q000166:cytology; D004195:Disease Models, Animal; D004728:Endothelium, Corneal / Q000166:cytology*; D019573:Epithelium, Corneal / Q000166:cytology*; D006801:Humans; D066298:In Vitro Techniques; D016850:Limbus Corneae / Q000166:cytology*; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods
keywords: Cell therapy; Cornea; Stem cell; Tissue engineering; Transplantation