title: Glioblastoma with primitive neuronal pattern in a girl aged 3 months: a rare diagnosis at an unusual age.
abstract: A girl aged 3 months presented with multiple seizures within 12 hours and was noted to have a palpable swelling over the right temporal region. MRI of the brain revealed a large right frontotemporal tumour, suggestive of supratentorial primitive neuroectodermal tumour. She underwent a stealth-guided craniotomy and debulking of the tumour. Histopathology and immunochemistry of the specimen, however, indicated a high-grade tumour with glioblastoma and neuroblastic components. She underwent adjuvant chemotherapy following the surgery and is well at 7-month follow-up. This case underscores the importance of considering the rare entity of glioblastoma with primitive neuronal pattern as a differential diagnosis in a young child.
authors.affiliation: Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia.
authors.forename: Chi Hau
authors.initials: CH
authors.lastname: Tan
authors.affiliation: Department of Anatomical Pathology, Monash Health, Clayton, Victoria, Australia.
authors.forename: Teik Beng
authors.initials: TB
authors.lastname: Phung
authors.affiliation: Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: Xenos
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D018193:Neoplasms, Complex and Mixed / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D018242:Neuroectodermal Tumors, Primitive / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy