title: Posaconazole Plasma Monitoring in Immunocompromised Children.
abstract: Plasma posaconazole exposure was assessed in 13 children who underwent a hematopoietic stem cell transplant. The median dosage was 12.5 mg/kg per day, divided into 3 doses. Of these 13 patients, 46.2% (6) and 30.8% (4) achieved concentrations higher than 0.7 and 1.25 mg/L, respectively. In children at high risk, a higher dosage might be needed to achieve target concentrations.
authors.affiliation: Department of Pharmacy.
authors.forename: Jessica
authors.initials: J
authors.lastname: McMahon
authors.affiliation: Research Centre.|Infectious Diseases Division, Department of Pediatrics.|Hemato-Oncology Division, Department of Pediatrics, CHU Sainte-Justine-Université de Montréal, Québec, Canada.
authors.forename: Yves
authors.initials: Y
authors.lastname: Théorêt
authors.affiliation: Research Centre.|Infectious Diseases Division, Department of Pediatrics.|Hemato-Oncology Division, Department of Pediatrics, CHU Sainte-Justine-Université de Montréal, Québec, Canada.|Clinical Pharmacology Unit, CHU Sainte-Justine, Montréal, Québec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Autmizguine
authors.affiliation: Department of Pharmacology, Université de Montréal, Québec, Canada.
authors.forename: Henrique
authors.initials: H
authors.lastname: Bittencourt
authors.affiliation: Clinical Pharmacology Unit, CHU Sainte-Justine, Montréal, Québec, Canada.
authors.forename: Bruce
authors.initials: B
authors.lastname: Tapiéro
authors.affiliation: Research Centre.|Clinical Pharmacology Unit, CHU Sainte-Justine, Montréal, Québec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ovetchkine
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood*
chemical_list: D014230:Triazoles; C101425:posaconazole
keywords: children; monitoring; posaconazole