title: Lipid peroxidation in cell death.
abstract: Disruption of redox homeostasis is a key phenotype of many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative stress, increasingly, attention is focused on the role of lipid hydroperoxides as critical mediators of death and disease. As the main component of cellular membranes, lipids have an indispensible role in maintaining the structural integrity of cells. Excessive oxidation of lipids alters the physical properties of cellular membranes and can cause covalent modification of proteins and nucleic acids. This review discusses the synthesis, toxicity, degradation, and detection of lipid peroxides in biological systems. Additionally, the role of lipid peroxidation is highlighted in cell death and disease, and strategies to control the accumulation of lipid peroxides are discussed.
authors.affiliation: Department of Chemistry, Columbia University, 550 West 120th Street, Northwest Corner Building, MC 4846, New York, NY 10027, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Gaschler
authors.affiliation: Department of Chemistry, Columbia University, 550 West 120th Street, Northwest Corner Building, MC 4846, New York, NY 10027, USA; Department of Biological Sciences, Columbia University, 550 West 120th Street, Northwest Corner Building, MC 4846, New York, NY 10027, USA. Electronic address: BStockwell@columbia.edu.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Stockwell
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism; D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008054:Lipid Peroxides / Q000378:metabolism / Q000633:toxicity; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D053858:Metabolic Networks and Pathways; D010084:Oxidation-Reduction; D019163:Reducing Agents / Q000494:pharmacology
chemical_list: D008054:Lipid Peroxides; D016859:Lipoxygenase Inhibitors; D019163:Reducing Agents
keywords: Antioxidant; Ferroptosis; Lipid oxidation; Neurodegeneration; Oxidation; Peroxidation