title: Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method.
abstract: The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.
authors.affiliation: University of Belgrade - Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: mkrstic109@gmail.com.
authors.forename: Marko
authors.initials: M
authors.lastname: Krstić
authors.affiliation: University of Belgrade - Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia.
authors.forename: Marija
authors.initials: M
authors.lastname: Radojević
authors.affiliation: University of Belgrade - Faculty of Technology and Metallurgy, Department of Materials Science and Engineering, Karnegijeva 4, 11120 Belgrade, Serbia.
authors.forename: Dušica
authors.initials: D
authors.lastname: Stojanović
authors.affiliation: University of Belgrade - Faculty of Technology and Metallurgy, Department of Materials Science and Engineering, Karnegijeva 4, 11120 Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Radojević
authors.affiliation: University of Belgrade - Faculty of Technology and Metallurgy, Department of Materials Science and Engineering, Karnegijeva 4, 11120 Belgrade, Serbia.
authors.forename: Petar
authors.initials: P
authors.lastname: Uskoković
authors.affiliation: University of Belgrade - Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ibrić
mesh_terms: D002227:Carbazoles / Q000737:chemistry*; D000077261:Carvedilol; D002626:Chemistry, Pharmaceutical / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011412:Propanolamines / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
chemical_list: D002227:Carbazoles; D011108:Polymers; D011412:Propanolamines; D012996:Solutions; D012997:Solvents; D000077261:Carvedilol; D011092:Polyethylene Glycols
keywords: Dissolution rate; Formulation parameters; Nanofibers; Oral films; Poly (ethylene oxide); Process parameters