title: A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy.
abstract: A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility. In this work, the distribution of superparamagnetic nanoparticles in the solid dispersion of polyethylene glycol with average molecular weight 950-1050 g/mol and phenacetin was studied using atomic force and magnetic force microscopy. The distribution of nanoparticles was found to be uniform in studied composites. Magnetically active solid dispersions may find application in the production of the capsulated drug delivery systems with enhanced solubility parameters.
authors.affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia.
authors.forename: Liana Stanislavovna
authors.initials: LS
authors.lastname: Usmanova
authors.affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia.
authors.forename: Marat Akhmedovich
authors.initials: MA
authors.lastname: Ziganshin
authors.affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia.
authors.forename: Valery Vilenovich
authors.initials: VV
authors.lastname: Gorbatchuk
authors.affiliation: Kazan Scientific Center, E. K. Zavoisky Physical-Technical Institute, Russian Academy of Sciences, Kazan, Russia.
authors.forename: Sufia Askhatovna
authors.initials: SA
authors.lastname: Ziganshina
authors.affiliation: Kazan Scientific Center, E. K. Zavoisky Physical-Technical Institute, Russian Academy of Sciences, Kazan, Russia.
authors.forename: Dmitry Anatolevich
authors.initials: DA
authors.lastname: Bizyaev
authors.affiliation: Kazan Scientific Center, E. K. Zavoisky Physical-Technical Institute, Russian Academy of Sciences, Kazan, Russia.
authors.forename: Anastas Akhmetovich
authors.initials: AA
authors.lastname: Bukharaev
authors.affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia.
authors.forename: Timur Anvarovich
authors.initials: TA
authors.lastname: Mukhametzyanov
authors.affiliation: Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia.
authors.forename: Alexander Vladimirovich
authors.initials: AV
authors.lastname: Gerasimov
keywords: Atomic force microscopy; magnetic force microscopy; magnetic nanoparticles; phenacetin; polyethylene glycol; solid dispersion