title: Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?
abstract: Purpose. To determine if the MMP-9 genotype has an influence on development of pituitary adenoma (PA).Methodology. The study enrolledn= 86 patients with PA andn= 526 healthy controls (reference group). The genotyping of MMP-9 was carried out using the real-time polymerase chain reaction method.Results. Our data demonstrated that the MMP-9 (-1562) C/C genotype was more frequent in PA group than in healthy controls (81.4% versus 64.6%,p= 0.002); C/C genotype was more frequently present in PA females compared to healthy control females, 81.5% versus 64.6%,p= 0.018, as well. MMP-9 (-1562) C/C genotype was frequently observed for all subgroups: noninvasive and invasive, nonrecurrence, and inactive PA compared to healthy controls: 81.8% versus 64.6%,p= 0.021; 81.0% versus 64.6%,p= 0.041; 81.8% versus 64.6%,p= 0.005; 100.0% versus 64.6%,p< 0.001, respectively. MMP-9 (-1562) C/C genotype was more frequent in inactive PA compared to active PA: 100.0% versus 71.4%;p< 0.001.Conclusion. MMP-9 (-1562) C/C genotype plays a role in nonrecurrence, inactive, and invasive as well as in nonivasive PA development.
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Brigita
authors.identifier: 0000-0002-1259-4999
authors.initials: B
authors.lastname: Glebauskiene
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania; Medical Academy, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Rasa
authors.initials: R
authors.lastname: Liutkeviciene
authors.affiliation: Medical Academy, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Alvita
authors.identifier: 0000-0002-0427-5568
authors.initials: A
authors.lastname: Vilkeviciute
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania; Medical Academy, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Loresa
authors.initials: L
authors.lastname: Kriauciuniene
authors.affiliation: Medical Academy, Radiology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Silvija
authors.initials: S
authors.lastname: Jakstiene
authors.affiliation: Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Egle
authors.identifier: 0000-0002-4838-992X
authors.initials: E
authors.lastname: Zlatkute
authors.affiliation: Medical Academy, Cardiology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Abdonas
authors.initials: A
authors.lastname: Tamosiunas
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Reda
authors.identifier: 0000-0002-3354-8879
authors.initials: R
authors.lastname: Zemaitiene
authors.affiliation: Medical Academy, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Paulina
authors.initials: P
authors.lastname: Vaitkiene
authors.affiliation: Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Dalia
authors.identifier: 0000-0002-4800-7629
authors.initials: D
authors.lastname: Zaliuniene
mesh_terms: D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D020780:Matrix Metalloproteinase 9