title: Management of uterine leiomyosarcoma.
abstract: The low incidence of uterine sarcomas requires many issues associated with its biology and clinical course to be followed with more research. Unsatisfactory surgical outcomes and a high risk of cancer dissemination make it worthwhile to consider the feasibility of supplementary systemic treatment. The currently employed chemo- and hormonal therapy is characterised by low efficacy. There is some hope in reports on targeted treatment. However, a comprehensive assessment of the efficacy of this kind of therapy is restricted by a small number of patients using it. Moreover, clinical studies using targeted therapies involve patients with a highly advanced disease, and the therapeutic results are assessed mainly via analysis of progression-free survival but not the clinical response.
authors.affiliation: Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin, Polska.
authors.forename: Marcin
authors.initials: M
authors.lastname: Bobiński
authors.affiliation: Katedra i Klinika Położnictwa i Patologii Ciąży, Uniwersyet Medyczny, Lublin, Polska.
authors.forename: Janusz Jacek
authors.initials: JJ
authors.lastname: Kraczkowski
authors.affiliation: Frauenklinik, Augusta-Kranken-Anstalt Bochum, Niemcy.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Witt
authors.affiliation: Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin, Polska.
authors.forename: Iwona
authors.initials: I
authors.lastname: Wertel
authors.affiliation: Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin, Polska.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Polak
authors.affiliation: Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin, Polska.
authors.forename: Jan
authors.initials: J
authors.lastname: Kotarski
authors.affiliation: Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin, Polska.
authors.forename: Wiesława
authors.initials: W
authors.lastname: Bednarek
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D019468:Disease Management; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D017410:Practice Guidelines as Topic; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents
keywords:  chemotherapy;  surgical treatment ; uterine sarcoma