title: Anthracycline Chemotherapy and Cardiotoxicity.
abstract: Anthracycline chemotherapy maintains a prominent role in treating many forms of cancer. Cardiotoxic side effects limit their dosing and improved cancer outcomes expose the cancer survivor to increased cardiovascular morbidity and mortality. The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other indirect pathways. Cardioprotective treatments are few and those that have been examined include renin angiotensin system blockade, beta blockers, or the iron chelator dexrazoxane. New treatments exploiting the ErbB or other novel pro-survival pathways, such as conditioning, are on the cardioprotection horizon. Even in the forthcoming era of targeted cancer therapies, the substantial proportion of today's anthracycline-treated cancer patients may become tomorrow's cardiac patient.
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, WC1E 6HX, UK.
authors.forename: John V
authors.initials: JV
authors.lastname: McGowan
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, WC1E 6HX, UK.
authors.forename: Robin
authors.initials: R
authors.lastname: Chung
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, WC1E 6HX, UK.
authors.forename: Angshuman
authors.initials: A
authors.lastname: Maulik
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, WC1E 6HX, UK.
authors.forename: Izabela
authors.initials: I
authors.lastname: Piotrowska
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, WC1E 6HX, UK.
authors.forename: J Malcolm
authors.initials: JM
authors.lastname: Walker
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, WC1E 6HX, UK. d.yellon@ucl.ac.uk.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Yellon
mesh_terms: D000818:Animals; D018943:Anthracyclines / Q000009:adverse effects*; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D066126:Cardiotoxicity; D002317:Cardiovascular Agents / Q000627:therapeutic use; D019610:Cytoprotection; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects; D013997:Time Factors; D014336:Troponin / Q000378:metabolism
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D002317:Cardiovascular Agents; D014336:Troponin
keywords: Cancer anthracycline doxorubicin chemotherapy cardiotoxicity cardioprotection