title: Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic destructive inflammation in synovial joints. To date, many studies explored the associations between tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs6920220, rs2230926, and rs5029937 polymorphisms and the risk of rheumatoid arthritis (RA), but with contradictory results. We therefore conducted a comprehensive meta-analysis to address the associations. We searched in the databases of PubMed and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the Stata 11.0 software. A total of 21 case-control studies for these three single nucleotide polymorphisms (SNPs) were included in this meta-analysis. Meta-analysis indicated that TNFAIP3 gene rs6920220, rs2230926, and rs5029937 polymorphisms were associated with the increased risk of RA. Stratification analysis of ethnicity found that rs6920220 and rs5029937 polymorphisms increased the risk of RA among Caucasians, while rs2230926 polymorphism increased the risk of RA among Asians. In summary, this meta-analysis confirms that TNFAIP3 gene polymorphisms may play important roles in the pathogenesis of RA.
authors.affiliation: Department of Clinical Pharmacy, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Shen
authors.affiliation: Department of Minimally Invasive Spine Center, Renji Orthopedics Hospital, Shantou 515065, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ruan
authors.affiliation: Department of Orthopedics, Jiangyin No 3 People's Hospital, Jiangyin 214433, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Orthopedics, The Affiliated Changzhou No 2 Hospital of Nanjing Medical University, Changzhou 213003, China.
authors.forename: Gongming
authors.initials: G
authors.lastname: Gao
authors.affiliation: Department of Orthopedics, The Affiliated Changzhou No 2 Hospital of Nanjing Medical University, Changzhou 213003, China.
authors.forename: Luming
authors.initials: L
authors.lastname: Nong
authors.affiliation: Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Ren
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3 / Q000235:genetics*
chemical_list: C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3
keywords: TNFAIP3; meta-analysis; rheumatoid arthritis; single nucleotide polymorphism