title: Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps.
abstract: Exercise-associated muscle cramping (EAMC) is a poorly understood problem that is neuromuscular in origin. Ingestion of transient receptor potential (TRP) channel agonists has been efficacious in attenuating electrically induced muscle cramps. This study examines the effect of TRP agonist ingestion on voluntarily induced EAMC and motor function.
  
  
  
  Study 1: Thirty-nine participants completed 2 trials after ingesting TRP agonist-containing active treatment (A), or vehicle (V) control. Cramping in the triceps surae muscle was induced via voluntary isometric contraction. Study 2: After ingesting A or V, 31 participants performed kinematic and psychomotor tests of manual dexterity.
  
  
  
  A increased precramp contraction duration (A, 36.9 ± 4.1 s; V, 27.8 ± 3.1 s), decreased cramp EMG area under the curve (A, 37.3 ± 7.7 %EMGmax·s; V, 77.2 ± 17.7 %EMGmax·s), increased contraction force to produce the cramp (A, 13.8 ± 1.8 kg; V, 9.9 ± 1.6 kg), and decreased postcramp soreness (A, 4.1 ± 0.3 arbitrary units (a.u.); V, 4.7 ± 0.3 a.u.). Kinematic and psychomotor tests were not affected.
  
  
  
  TRP agonist ingestion attenuated EAMC characteristics without affecting motor function. Muscle Nerve 56: 379-385, 2017.
authors.affiliation: Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Craighead
authors.affiliation: Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
authors.forename: Sean W
authors.initials: SW
authors.lastname: Shank
authors.affiliation: Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
authors.forename: Jinger S
authors.initials: JS
authors.lastname: Gottschall
authors.affiliation: Scout Consulting, LLC, Hebron, Illinois, USA.
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Passe
authors.affiliation: Sports Science Insights, LLC, Crystal lake, Illinois, USA.
authors.forename: Bob
authors.initials: B
authors.lastname: Murray
authors.affiliation: Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
authors.forename: Lacy M
authors.initials: LM
authors.lastname: Alexander
authors.affiliation: Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
authors.forename: W Larry
authors.initials: WL
authors.lastname: Kenney
mesh_terms: D000328:Adult; D001628:Beverages; D015220:Calcium Channels / Q000502:physiology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology; D004576:Electromyography / Q000187:drug effects* / Q000379:methods; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009120:Muscle Cramp / Q000188:drug therapy* / Q000209:etiology; D018763:Muscle Fatigue / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000819:agonists* / Q000502:physiology; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000819:agonists* / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000819:agonists* / Q000502:physiology; D055815:Young Adult
chemical_list: D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D050051:Transient Receptor Potential Channels
keywords: EMG; TRPA1; TRPV1; exercise-associated muscle cramp; α-motor neuron hyperexcitability