title: Arginine methylation dysfunction increased risk of acute coronary syndrome in coronary artery disease population: A case-control study.
abstract: The plasma levels of asymmetric dimethylarginine (ADMA) had been proved to be an independent cardiovascular risk factor. Few studies involved the entire arginine methylation dysfunction. This study was designed to investigate whether arginine methylation dysfunction is associated with acute coronary syndrome risk in coronary artery disease population.In total 298 patients undergoing coronary angiography because of chest pain with the diagnosis of stable angina pectoris or acute coronary syndrome from February 2013 to June 2014 were included. Plasma levels of free arginine, citrulline, ornithine, and the methylated form of arginine, ADMA, and symmetric dimethylarginine (SDMA) were measured with high-performance liquid chromatography coupled with tandem mass spectrometry. We examined the relationship between arginine metabolism-related amino acids or arginine methylation index (AMI, defined as ratio of [arginine + citrulline + ornithine]/[ADMA + SDMA]) and acute coronary events.We found that plasma ADMA levels were similar in the stable angina pectoris group and the acute coronary syndrome group (P = 0.88); the AMI differed significantly between 2 groups (P < 0.001). Multivariate logistic regression demonstrated that AMI was an independent risk factor of acute coronary events in patients with coronary artery disease (OR = 0.975, 95% confidence interval 0.956-0.993; P = 0.008).Our study suggested that ADMA levels were very similar in the stable angina and acute coronary syndrome patients; AMI might be an independent risk factor of acute coronary events in coronary artery disease population.
authors.affiliation: Department of Internal Medicine Department of Cardiology Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Shengyu
authors.initials: S
authors.lastname: Zhang
authors.forename: Shuyang
authors.initials: S
authors.lastname: Zhang
authors.forename: Hongyun
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Yicong
authors.initials: Y
authors.lastname: Ye
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology / Q000378:metabolism*; D000368:Aged; D001120:Arginine / Q000378:metabolism*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011484:Protein-Arginine N-Methyltransferases / Q000378:metabolism*; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D001120:Arginine; D011484:Protein-Arginine N-Methyltransferases