title: ProBiS tools (algorithm, database, and web servers) for predicting and modeling of biologically interesting proteins.
abstract: ProBiS (Protein Binding Sites) Tools consist of algorithm, database, and web servers for prediction of binding sites and protein ligands based on the detection of structurally similar binding sites in the Protein Data Bank. In this article, we review the operations that ProBiS Tools perform, provide comments on the evolution of the tools, and give some implementation details. We review some of its applications to biologically interesting proteins. ProBiS Tools are freely available at http://probis.cmm.ki.si and http://probis.nih.gov.
authors.affiliation: National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, SI-6000, Koper, Slovenia.
authors.forename: Janez
authors.initials: J
authors.lastname: Konc
authors.affiliation: Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, SI-6000, Koper, Slovenia. Electronic address: dusanka.janezic@upr.si.
authors.forename: Dušanka
authors.initials: D
authors.lastname: Janežič
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D011506:Proteins
keywords: Binding sites; Prediction; ProBiS; Protein structure; Structural similarity