title: Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective.
abstract: OBJECTIVE
  To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD).
  
  
  METHODS
  Patients with ulcerative colitis (UC) or Crohn's disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin D concentration checked. Logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, CD, race, age, gender and body mass index (BMI).
  
  
  RESULTS
  We identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have vitamin D concentration checked. Bivariate analysis showed that AA (51%vs21%,P= 0.00001), subjects with BMI >30 kg/m2(39%vs23%P= 0.01) and CD (40%vs26%,P= 0.04) were more likely to be vitamin D deficient than vitamin D sufficient. Those with Age > 65 were more likely to be vitamin D sufficient (46%vs15%,P= 0.04). Multiple regression showed that only BMI > 30 kg/m2and AA race are associated with vitamin D deficiency.
  
  
  CONCLUSIONS
  BMI > 30 kg/m2and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency.
authors.affiliation: Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: Kumar
authors.initials: K
authors.lastname: Pallav
authors.affiliation: Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Riche
authors.affiliation: Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: Warren L
authors.initials: WL
authors.lastname: May
authors.affiliation: Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sanchez
authors.affiliation: Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: Nitin K
authors.initials: NK
authors.lastname: Gupta
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D001706:Biopsy; D015992:Body Mass Index; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000453:epidemiology; D003424:Crohn Disease / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008922:Mississippi / Q000453:epidemiology; D016017:Odds Ratio; D010865:Pilot Projects; D012044:Regression Analysis; D012189:Retrospective Studies; D012621:Seasons; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: African American; Body mass index; Crohn’s disease; Inflammatory bowel disease; Ulcerative colitis; Vitamin D deficiency