title: Regulation of Cellular Processes by SUMO: Understudied Topics.
abstract: SUMO plays a multiple role in maintenance of cellular homeostasis, both under normal conditions and under cell stress . Considerable effort has been devoted to unraveling the functions of SUMO in regulation of transcription and preservation of genome stability. However, it is clear from high-throughput SUMO proteome studies that SUMO likely regulates many more cellular processes. The function of SUMO in these processes has hardly been explored. This review will focus on the emerging function of SUMO in regulation of several of these processes.
authors.affiliation: Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital and University of Oslo, Ullernchausseen 70, 0379, Oslo, Norway. jorrit.enserink@rr-research.no.
authors.forename: Jorrit M
authors.initials: JM
authors.lastname: Enserink
mesh_terms: D000818:Animals; D042822:Genomic Instability; D006706:Homeostasis; D006801:Humans; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D013312:Stress, Physiological; D058207:Sumoylation; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; D044767:Ubiquitin-Protein Ligases
keywords: Autophagy; Cell cycle; Chromosome stability; Lipogenesis; Protein folding; SUMO; Transcription; mRNA modification