title: Neurodegenerative Disease Transmission and Transgenesis in Mice.
abstract: Although the discovery of the prion protein (PrP) resulted from its co-purification with scrapie infectivity in Syrian hamsters, work with genetically defined and genetically modified mice proved crucial for understanding the fundamental processes involved not only in prion diseases caused by PrP misfolding, aggregation, and spread but also in other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological and conceptual approaches used to study scrapie and related PrP misfolding diseases in mice and how these approaches have advanced our understanding of related disorders including Alzheimer's and Parkinson's disease.
authors.affiliation: Institute for Neurodegenerative Diseases, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94158.
authors.forename: Brittany N
authors.initials: BN
authors.lastname: Dugger
authors.affiliation: F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Perl
authors.affiliation: Institute for Neurodegenerative Diseases, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94158.|McLaughlin Research Institute of Biomedical Sciences, Great Falls, Montana 59405.
authors.forename: George A
authors.initials: GA
authors.lastname: Carlson
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000209:etiology*; D017096:Prion Diseases / Q000635:transmission*