title: A new cell cycle checkpoint that senses plasma membrane/cell wall damage in budding yeast.
abstract: In nature, cells face a variety of stresses that cause physical damage to the plasma membrane and cell wall. It is well established that evolutionarily conserved cell cycle checkpoints monitor various cellular perturbations, including DNA damage and spindle misalignment. However, the ability of these cell cycle checkpoints to sense a damaged plasma membrane/cell wall is poorly understood. To the best of our knowledge, our recent paper described the first example of such a checkpoint, using budding yeast as a model. In this review, we will discuss this important question as well as provide hypothetical explanations to be tested in the future.
authors.affiliation: Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kono
authors.affiliation: Department of Biology, Brooklyn College, The City University of New York, Brooklyn, NY, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Ikui
mesh_terms: D059447:Cell Cycle Checkpoints; D002462:Cell Membrane / Q000502:physiology*; D002473:Cell Wall / Q000502:physiology*; D004718:Saccharomycetales / Q000378:metabolism / Q000502:physiology*
keywords: Cdc6; cell cycle checkpoint; plasma membrane/cell wall damage; stress response; yeast