title: Implantable optoelectronic probes for in vivo optogenetics.
abstract: More than a decade has passed since optics and genetics came together and lead to the emerging technologies of optogenetics. The advent of light-sensitive opsins made it possible to optically trigger the neurons into activation or inhibition by using visible light. The importance of spatiotemporally isolating a segment of a neural network and controlling nervous signaling in a precise manner has driven neuroscience researchers and engineers to invest great efforts in designing high precision in vivo implantable devices. These efforts have focused on delivery of sufficient power to deep brain regions, while monitoring neural activity with high resolution and fidelity. In this review, we report the progress made in the field of hybrid optoelectronic neural interfaces that combine optical stimulation with electrophysiological recordings. Different approaches that incorporate optical or electrical components on implantable devices are discussed in detail. Advantages of various different designs as well as practical and fundamental limitations are summarized to illuminate the future of neurotechnology development.
authors.affiliation: Department of Electrical and Computer Engineering, University of California, San Diego, CA, United States of America.
authors.forename: Ege
authors.initials: E
authors.lastname: Iseri
authors.forename: Duygu
authors.initials: D
authors.lastname: Kuzum
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007834:Lasers; D062308:Optogenetics / Q000295:instrumentation* / Q000379:methods; D019736:Prostheses and Implants; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity