title: Magnetic Resonance Spectroscopy-Detected Change in Marrow Adiposity Is Strongly Correlated to Postmenopausal Breast Cancer Risk.
abstract: To determine whether marrow fat fraction (FF) is correlated with postmenopausal breast cancer risk and clinicopathological characteristics of breast cancer.
  
  
  
  Fifty-six patients with newly diagnosed and histologically confirmed postmenopausal breast cancer and 56 healthy controls underwent serologic test and magnetic resonance spectroscopy-based FF measurements. Data were analyzed by logistic multivariate regression models to determine the independent predictors of breast cancer risk and clinicopathological characters of breast cancer.
  
  
  
  Patients with breast cancer had higher FF than that of the controls. Marrow FF showed positive association with serum leptin levels (r = 0.607, P < .001) in the cases, but no relationship was found in the controls. In the univariate analysis, both levels of leptin and marrow FF were significantly associated with breast cancer risk and clinicopathological characteristics of breast cancer. In the multivariable model with adjustment for established breast cancer risk factors, serum leptin was a significant predictor of breast cancer risk (OR 1.746; 95% CI, 1.226-2.556) and clinicopathological characteristics of breast cancer including TNM, tumor size, lymph node status, and histological grade (OR 1.461-1.695); but when marrow FF was additionally added to the regression model, marrow FF but not leptin levels was observed to be an independent risk factor for breast cancer risk (OR 1.940; 95% CI, 1.306-2.910) and clinicopathological characteristics of breast cancer (OR 1.770-1.903).
  
  
  
  Marrow adiposity is a predictor of postmenopausal breast cancer risk and clinicopathological characteristics of breast cancer.
authors.affiliation: Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: purenyi@163.com.
authors.forename: Guanwu
authors.initials: G
authors.lastname: Li
authors.affiliation: Xinzhuang Community Health Center, Shanghai, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Radiology, Wayne State University, Detroit, MI.
authors.forename: Alex
authors.initials: A
authors.lastname: Zhuang
authors.affiliation: Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Shixin
authors.initials: S
authors.lastname: Chang
authors.affiliation: Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.
authors.forename: Lingmi
authors.initials: L
authors.lastname: Hou
authors.affiliation: Department of Radiology, Wayne State University, Detroit, MI.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Medicine and Public Health, University of Wisconsin, Madison, WI.
authors.forename: Maki
authors.initials: M
authors.lastname: Polat
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000473:pathology*; D050154:Adiposity; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D017698:Postmenopause; D011379:Prognosis; D012307:Risk Factors
keywords: Bone metastasis; Leptin; Marrow fat content; Menopause