title: Minimal clinically important differences for the experiences of daily living parts of movement disorder society-sponsored unified Parkinson's disease rating scale.
abstract: The minimal clinically important difference is the smallest change of scores clinically meaningful to patients.
  
  
  
  We aimed to calculate these threshold values in association with the International Parkinson and Movement Disorder Society UPDRS (MDS-UPDRS) Parts I and II and to evaluate the feasibility of the composite score of Part I and II (MDS-UPDRS I+II) as an outcome.
  
  
  
  Nine hundred eighty-five paired investigations of 365 patients were reviewed, implementing three different techniques simultaneously.
  
  
  
  Based on the ordinal regression modeling, the MDS-UPDRS I+II score is an applicable outcome measure. Any improvement greater than 2.64 points or any worsening more than 2.45 points on MDS-UPDRS Part I represent a minimal, yet clinically meaningful change. In reference to Part II, the smallest changes considered clinically relevant were 3.05 and 2.51 points for improvement and deterioration, respectively. The thresholds for MDS-UPDRS I+II were 5.73 points for improvement and 4.70 points for worsening.
  
  
  
  Our minimal clinically important difference thresholds can be utilized in clinical practice in judging clinical relevance. © 2016 International Parkinson and Movement Disorder Society.
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Horváth
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary.|Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Aschermann
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary.|Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Márton
authors.initials: M
authors.lastname: Kovács
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary.|Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Makkos
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary.|Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Márk
authors.initials: M
authors.lastname: Harmat
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary.|MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Janszky
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Sámuel
authors.initials: S
authors.lastname: Komoly
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Pécs, Hungary.|Department of Behavioral Sciences, Universiyt of Pecs, Hungary.
authors.forename: Kázmér
authors.initials: K
authors.lastname: Karádi
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary.|MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary.
authors.forename: Norbert
authors.initials: N
authors.lastname: Kovács
mesh_terms: D000203:Activities of Daily Living; D016208:Databases, Factual; D006801:Humans; D000071081:Minimal Clinically Important Difference; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D012372:ROC Curve; D012044:Regression Analysis; D012955:Societies, Medical; D011795:Surveys and Questionnaires; D006113:United Kingdom
keywords: UPDRS; minimal but clinically relevant differences; minimal clinically important changes; patient reported outcomes; receiver operating characteristic curve