title: Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice.
abstract: Rhaphidophora pinnatais suggested to prevent or treat cancer of genetic mutations. In this study, antimutagenic activity of an ethanol extract ofRhaphidophora pinnataleaves was evaluated by using a bone marrow micronucleus assay on mice. Male mice (20-30 g) were treated for sevendays with an ethanol extract ofRhaphidophora pinnataleaves at a dose of 500, 750 and 1000 mg/kg/day/orally, prior to exposure to cyclophosphamide (i.p. 30 mg/kg), 24 h after the end of the treatment. Antimutagenic activity was determined by the decrease of micronuclei (MN). The results showed that a single administration of all variant doses of the extract had significantly decreased the micronucleus formation in bone marrow cell of mice as compared to the cyclophosphamide group. The ethanol extract ofRhaphidophora pinnataleaves had antimutagenic activity against cyclophosphamide-induced gene mutation.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Tri Dharma Street, No.5, Medan 20155, Indonesia. fia.mustafa@yahoo.com.
authors.lastname: Masfria
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sumatera Utara, Tri Dharma Street, No.5, Medan 20155, Indonesia. sumaiyah7777@gmail.com.
authors.lastname: Sumaiyah
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Tri Dharma Street, No.5, Medan 20155, Indonesia. aminah1@usu.ac.id.
authors.forename: Aminah
authors.initials: A
authors.lastname: Dalimunthe
keywords: Antimutagenic activity; Rhaphidophora pinnata leaves; ethanol extract