title: Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience.
abstract: The different results from flat panel detector CT in various pathologies have provoked some discussion. Our aim was to assess the role of flat panel detector CT in brain arteriovenous malformations, which has not yet been assessed. Five patients with brain arteriovenous malformations were studied with flat panel detector CT, DSC-MR imaging, and vessel-encoded pseudocontinuous arterial spin-labeling. In glomerular brain arteriovenous malformations, perfusion was highest next to the brain arteriovenous malformation with decreasing values with increasing distance from the lesion. An inverse tendency was observed in the proliferative brain arteriovenous malformation. Flat panel detector CT, originally thought to measure blood volume, correlated more closely with arterial spin-labeling-CBF and DSC-CBF than with DSC-CBV. We conclude that flat panel detector CT perfusion depends on the time point chosen for data collection, which is triggered too early in these patients (ie, when contrast agent appears in the superior sagittal sinus after rapid shunting through the brain arteriovenous malformation). This finding, in combination with high data variability, makes flat panel detector CT inappropriate for perfusion assessment in brain arteriovenous malformations.
authors.affiliation: From the Division of Diagnostic and Interventional Neuroradiology (M. Garcia) meritxell.garcia@usb.ch.|Nuffield Department of Surgical Sciences and Department of Neuroradiology (M. Garcia, J.V.B.).
authors.forename: M
authors.identifier: 0000-0002-7946-5462
authors.initials: M
authors.lastname: Garcia
authors.affiliation: Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre) (T.W.O., M.A.C., P.J.), Nuffield Department of Neurosciences.
authors.forename: T W
authors.identifier: 0000-0001-8258-0659
authors.initials: TW
authors.lastname: Okell
authors.affiliation: Division of Radiological Physics (M. Gloor, O.B.), Department of Radiology Clinic for Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland.
authors.forename: M
authors.identifier: 0000-0003-3272-4938
authors.initials: M
authors.lastname: Gloor
authors.affiliation: Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre) (T.W.O., M.A.C., P.J.), Nuffield Department of Neurosciences.|Institute of Biomedical Engineering (M.A.C.), Department of Engineering, University of Oxford, Oxford, United Kingdom.
authors.forename: M A
authors.identifier: 0000-0003-1802-4214
authors.initials: MA
authors.lastname: Chappell
authors.affiliation: Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre) (T.W.O., M.A.C., P.J.), Nuffield Department of Neurosciences.
authors.forename: P
authors.identifier: 0000-0001-7912-2251
authors.initials: P
authors.lastname: Jezzard
authors.affiliation: Division of Radiological Physics (M. Gloor, O.B.), Department of Radiology Clinic for Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland.
authors.forename: O
authors.identifier: 0000-0002-6755-5495
authors.initials: O
authors.lastname: Bieri
authors.affiliation: Nuffield Department of Surgical Sciences and Department of Neuroradiology (M. Garcia, J.V.B.).
authors.forename: J V
authors.identifier: 0000-0002-1268-3000
authors.initials: JV
authors.lastname: Byrne
mesh_terms: D000328:Adult; D015901:Angiography, Digital Subtraction; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013113:Spin Labels; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D013113:Spin Labels