title: Effect of peritoneal dialysis fluids on activity of echinocandins against Candida spp. biofilm.
abstract: Peritoneal dialysis fluids (PDFs) impair microorganisms' growth, which may compromise effectivity of some antimicrobials. The purpose of this study was to investigate the effect of three different PDFs (lactate/bicarbonate-buffered Physioneal 40® with 2.2% glucose, lactate-buffered Nutrineal PD4® with 1.1% amino acid, and lactate-buffered Extraneal® with 7.5% icodextrin) on biofilm formation of four different Candida spp and antibiofilm effectiveness of anidulafungin, caspofungin and micafungin against Candida spp. biofilm in PDFs. All tested PDFs attained inhibitory effect on the biofilm formation but also reduced biofilm effectiveness of echinocandins against biofilm in PDFs was detected.
authors.affiliation: Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Guertel 18-20, 1090 Vienna, Austria.
authors.forename: Selma
authors.initials: S
authors.lastname: Tobudic
authors.affiliation: Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Guertel 18-20, 1090 Vienna, Austria.
authors.forename: Nicole
authors.initials: N
authors.lastname: Harrison
authors.affiliation: Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Guertel 18-20, 1090 Vienna, Austria.|Center for Infectious Diseases and Infection Control, Jena University Hospital, Erlanger Allee 101, 07749 Jena, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Forstner
authors.affiliation: Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Guertel 18-20, 1090 Vienna, Austria.
authors.forename: Manuel
authors.initials: M
authors.lastname: Kussman
authors.affiliation: Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Guertel 18-20, 1090 Vienna, Austria.
authors.forename: Heinz
authors.initials: H
authors.lastname: Burgmann
mesh_terms: D000935:Antifungal Agents / Q000378:metabolism*; D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000187:drug effects* / Q000502:physiology*; D015314:Dialysis Solutions / Q000737:chemistry / Q000378:metabolism*; D004347:Drug Interactions; D054714:Echinocandins / Q000378:metabolism*; D006801:Humans; D010530:Peritoneal Dialysis
chemical_list: D000935:Antifungal Agents; D015314:Dialysis Solutions; D054714:Echinocandins
keywords: Candida spp.; biofilm; echinocandins; peritoneal dialysis