title: Sumoylation and Its Contribution to Cancer.
abstract: Post-translational modifications play an important role in regulating protein activity by altering their functions. Sumoylation is a highly dynamic process which is tightly regulated by a fine balance between conjugating and deconjugating enzyme activities. It affects intracellular localization and their interaction with their binding partners, thereby changing gene expression. Consequently, these changes in turn affect signaling mechanisms that regulate many cellular functions, such as cell growth, proliferation, apoptosis , DNA repair , and cell survival. It is becoming apparent that deregulation in the SUMO pathway contributes to oncogenic transformation by affecting sumoylation/desumoylation of many oncoproteins and tumor suppressors. Loss of balance between sumoylation and desumoylation has been reported in a number of studies in a variety of disease types including cancer. This chapter summarizes the mechanisms and functions of the deregulated SUMO pathway affecting oncogenes and tumor suppressor genes.
authors.affiliation: Department of Biological Sciences, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Biological Sciences, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: Hee June
authors.initials: HJ
authors.lastname: Choi
authors.affiliation: Department of Biological Sciences, Seoul National University, Seoul, 151-742, South Korea. sbaek@snu.ac.kr.
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Baek
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics / Q000378:metabolism*; D058207:Sumoylation; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D025841:Small Ubiquitin-Related Modifier Proteins; D044767:Ubiquitin-Protein Ligases
keywords: Cancer; IκBα; Metastasis; NEMO; PIAS1; PML; Pontin; Reptin; SENP; SUMO; Sumoylation; TEL; Ubc9; p53