title: Wound healing effects of nanoemulsion containing clove essential oil.
abstract: The aim of this study was to investigate the wound healing effects of clove oil (CO) via its encapsulation into nanoemulsion. Optimized nanoemulsion (droplet size of 29.10 nm) was selected for wound healing investigation, collagen determination, and histopathological examination in rats. Optimized nanoemulsion presented significant would healing effects in rats as compared to pure CO. Nanoemulsion also presented significant enhancement in leucine content (0.61 mg/g) as compared to pure CO (0.50 mg/g) and negative control (0.31 mg/g). Histopathology of nanoemulsion treated rats showed no signs of inflammatory cells. These results suggested that nanoemulsion of CO was safe and nontoxic.
authors.affiliation: a Department of Pharmacognosy , College of Pharmacy, Prince Sattam Bin Abdulaziz University , Al-Kharj , Saudi Arabia.
authors.forename: Prawez
authors.initials: P
authors.lastname: Alam
authors.affiliation: b Department of Pharmaceutics , College of Pharmacy, Prince Sattam Bin Abdulaziz University , Al-Kharj , Saudi Arabia.
authors.forename: Mohammad J
authors.initials: MJ
authors.lastname: Ansari
authors.affiliation: b Department of Pharmaceutics , College of Pharmacy, Prince Sattam Bin Abdulaziz University , Al-Kharj , Saudi Arabia.
authors.forename: Md Khalid
authors.initials: MK
authors.lastname: Anwer
authors.affiliation: c Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Raish
authors.affiliation: a Department of Pharmacognosy , College of Pharmacy, Prince Sattam Bin Abdulaziz University , Al-Kharj , Saudi Arabia.
authors.forename: Yoonus K T
authors.initials: YK
authors.lastname: Kamal
authors.affiliation: d Center of Excellence in Biotechnology Research (CEBR) , King Saud University , Riyadh , Saudi Arabia.
authors.forename: Faiyaz
authors.initials: F
authors.lastname: Shakeel
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D045783:Clove Oil / Q000737:chemistry / Q000494:pharmacology*; D003094:Collagen / Q000819:agonists / Q000096:biosynthesis; D004655:Emulsions; D005260:Female; D005989:Glycerides / Q000737:chemistry; D049329:Nanostructures; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000293:injuries; D014215:Triacetin / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D045783:Clove Oil; D004655:Emulsions; D005989:Glycerides; D011136:Polysorbates; C440220:Labrasol; D003094:Collagen; D014215:Triacetin
keywords: Clove oil; collagen; histopathology; leucine; nanoemulsion; wound healing