title: Targeting IKK and NF-κB for Therapy.
abstract: In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signaling.
authors.affiliation: Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, United States; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States.
authors.forename: J K
authors.initials: JK
authors.lastname: Durand
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States. Electronic address: albert_baldwin@med.unc.edu.
authors.forename: A S
authors.initials: AS
authors.lastname: Baldwin
mesh_terms: D049109:Cell Proliferation; D002470:Cell Survival; D002986:Clinical Trials as Topic; D019008:Drug Resistance, Neoplasm; D006801:Humans; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B; D051550:I-kappa B Kinase
keywords: Cancer; IKK; Inflammation; NF-κB; Therapeutic targets; Transcription factor