title: Psoriasis and comorbid diseases: Epidemiology.
abstract: Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known comorbidity of psoriasis. A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders. The pathogenesis of comorbid disease in patients with psoriasis remains unknown; however, shared inflammatory pathways, cellular mediators, genetic susceptibility, and common risk factors are hypothesized to be contributing elements. As additional psoriasis comorbidities continue to emerge, education of health care providers is essential to ensuring comprehensive medical care for patients with psoriasis.
authors.affiliation: Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: Junko.Takeshita@uphs.upenn.edu.
authors.forename: Junko
authors.initials: J
authors.lastname: Takeshita
authors.affiliation: Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Sungat
authors.initials: S
authors.lastname: Grewal
authors.affiliation: London School of Hygiene and Tropical Medicine and St. John's Institute of Dermatology, London, United Kingdom.
authors.forename: Sinéad M
authors.initials: SM
authors.lastname: Langan
authors.affiliation: National Heart, Lung and Blood Institute, Bethesda, Maryland.
authors.forename: Nehal N
authors.initials: NN
authors.lastname: Mehta
authors.affiliation: Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Alexis
authors.initials: A
authors.lastname: Ogdie
authors.affiliation: Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia.
authors.forename: Abby S
authors.initials: AS
authors.lastname: Van Voorhees
authors.affiliation: Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Gelfand
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D006801:Humans; D007239:Infections / Q000453:epidemiology; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology; D008107:Liver Diseases / Q000453:epidemiology; D019964:Mood Disorders / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology*; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology
keywords: Crohn's disease; cardiovascular disease; chronic kidney disease; comorbidities; depression; infection; lymphoma; metabolic syndrome; nonalcoholic fatty liver disease; psoriasis; psoriatic arthritis