title: Plant arginyltransferases (ATEs).
abstract: Regulation of protein stability and/or degradation of misfolded and damaged proteins are essential cellular processes. A part of this regulation is mediated by the so-called N-end rule proteolytic pathway, which, in concert with the ubiquitin proteasome system (UPS), drives protein degradation depending on the N-terminal amino acid sequence. One important enzyme involved in this process is arginyl-t-RNA transferase, known as ATE. This enzyme acts post-translationally by introducing an arginine residue at the N-terminus of specific protein targets to signal degradation via the UPS. However, the function of ATEs has only recently begun to be revealed. Nonetheless, the few studies to date investigating ATE activity in plants points to the great importance of the ATE/N-end rule pathway in regulating plant signaling. Plant development, seed germination, leaf morphology and responses to gas signaling in plants are among the processes affected by the ATE/N-end rule pathway. In this review, we present some of the known biological functions of plant ATE proteins, highlighting the need for more in-depth studies on this intriguing pathway.
authors.affiliation: Laboratório de Virologia Molecular Vegetal, Departamento de Virologia IMPPG, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Domitrovic
authors.affiliation: Laboratório de Virologia Molecular Vegetal, Departamento de Virologia IMPPG, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Fausto
authors.affiliation: Departamento de Biotecnologia, Escola de Engenharia de Lorena, Universidade de São Paulo, Lorena, SP, Brazil.
authors.forename: Tatiane da F
authors.initials: TF
authors.lastname: Silva
authors.affiliation: Departamento de Biotecnologia, Escola de Engenharia de Lorena, Universidade de São Paulo, Lorena, SP, Brazil.
authors.forename: Elisson
authors.initials: E
authors.lastname: Romanel
authors.affiliation: Laboratório de Virologia Molecular Vegetal, Departamento de Virologia IMPPG, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Maite F S
authors.initials: MFS
authors.lastname: Vaslin