title: A Prospective Analysis of Olfactory Impairment Recovery After Severe Traumatic Brain Injury.
abstract: To investigate the natural progression of olfactory impairment (OI) in individuals with traumatic brain injury (TBI) at 6 months postinjury.
  
  
  
  Forty-seven adults (mean age = 43.1 years, SD = 18.2), with predominantly severe TBI (mean posttraumatic amnesia [PTA] duration = 25.5 days, SD = 22.8).
  
  
  
  Consecutive admission longitudinal study.
  
  
  
  Participants were evaluated using the University of Pennsylvania Smell Identification Test (UPSIT) at resolution of PTA and at 6 months post-initial injury. Each participant was also interviewed to explore his or her experience of having an OI. Standard multiple regression was used to assess the ability of age, PTA duration, presence of facial fractures, and initial UPSIT score to predict olfactory performance at 6 months.
  
  
  
  Thirty-five participants (74%) continued to demonstrate OI at 6 months. Thirty-two participants (68%) showed some improvement, but only 12 of these individuals achieved scores within the normal range. The remaining 15 participants either produced a poorer performance (23%) or demonstrated no change (9%). Initial UPSIT score uniquely accounted for 73.5% of the variance in UPSIT performance at 6 months.
  
  
  
  Olfactory impairment persists in a substantial proportion of adults who experience it post-TBI and has the potential to impact a broad spectrum of everyday activities.
authors.affiliation: College of Science, Health and Engineering, La Trobe University, Melbourne, Victoria, Australia (Ms Drummond and Dr Douglas); Epworth Monash Rehabilitation Medicine Unit, Epworth HealthCare, Richmond, Victoria, Australia (Ms Drummond and Dr Olver); Epworth Rehabilitation, Epworth HealthCare, Richmond, Victoria, Australia (Ms Drummond and Dr Olver); NHMRC Clinical Centre of Research Excellence in Brain Recovery, School of Psychology, University of New South Wales, Sydney, New South Wales, Australia (Dr Douglas); and Summer Foundation, Blackburn, Victoria, Australia (Dr Douglas).
authors.forename: Melanie
authors.initials: M
authors.lastname: Drummond
authors.forename: Jacinta
authors.initials: J
authors.lastname: Douglas
authors.forename: John
authors.initials: J
authors.lastname: Olver
mesh_terms: D000328:Adult; D000070642:Brain Injuries, Traumatic / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D011446:Prospective Studies; D020127:Recovery of Function; D012903:Smell / Q000502:physiology*; D013997:Time Factors