title: Plasma oxidative stress and inflammatory biomarkers are associated with the sizes of the left atrium and pulmonary vein in atrial fibrillation patients.
abstract: BACKGROUND
  Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AF patients remains unclear.
  
  
  OBJECTIVE
  Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AF patients.
  
  
  METHODS
  82 AF patients were compared to 30 control patients by using a case-control study design. Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were detected.
  
  
  RESULTS
  (1) Hs-CRP, IL-6, IL-8, TNF-α, MDA and ox-LDL were higher, and SOD was lower in AF patients than in control patients. Hs-CRP, MDA and ox-LDL were higher in permanent AF patients than in paroxysmal and persistent AF patients. (2) CsA of LSPV, RSPV, RIPV, LAA and LAV were statistically higher in AF patients than in control patients. CsA of RSPV, LSPV, LIPV and LAV were higher in permanent AF patients than in paroxysmal and persistent AF patients. (3) In the AF group, hs-CRP and TNF-α were positively correlated with LAV; MDA was positively correlated with CsA of LAA, LSPV and LAV; SOD was passively correlated with CsA of LAA and LAV; ox-LDL was positively correlated with CsA of LAA and LAV. Multivariate logistic regression analysis showed hs-CRP, ox-LDL, RSPV CsA, LIPV CsA and LAV were associated with AF.
  
  
  CONCLUSIONS
  Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were significantly increased in AF patients. Hs-CRP, ox-LDL, RSPV CsA, LIPV CsA and LAV were associated with AF persistence.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Jin-Yi
authors.initials: JY
authors.lastname: Li
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Hong-Hong
authors.initials: HH
authors.lastname: Ke
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Zhong
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000033:anatomy & histology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D007249:Inflammation / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D018384:Oxidative Stress; D011667:Pulmonary Veins / Q000033:anatomy & histology*; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D016207:Cytokines; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein
keywords: atrial fibrillation; inflammation; left atrium; oxidative stress; pulmonary vein