title: A generalized framework unifying image registration and respiratory motion models and incorporating image reconstruction, for partial image data or full images.
abstract: Surrogate-driven respiratory motion models relate the motion of the internal anatomy to easily acquired respiratory surrogate signals, such as the motion of the skin surface. They are usually built by first using image registration to determine the motion from a number of dynamic images, and then fitting a correspondence model relating the motion to the surrogate signals. In this paper we present a generalized framework that unifies the image registration and correspondence model fitting into a single optimization. This allows the use of 'partial' imaging data, such as individual slices, projections, or k-space data, where it would not be possible to determine the motion from an individual frame of data. Motion compensated image reconstruction can also be incorporated using an iterative approach, so that both the motion and a motion-free image can be estimated from the partial image data. The framework has been applied to real 4DCT, Cine CT, multi-slice CT, and multi-slice MR data, as well as simulated datasets from a computer phantom. This includes the use of a super-resolution reconstruction method for the multi-slice MR data. Good results were obtained for all datasets, including quantitative results for the 4DCT and phantom datasets where the ground truth motion was known or could be estimated.
authors.affiliation: Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
authors.forename: Jamie R
authors.initials: JR
authors.lastname: McClelland
authors.forename: Marc
authors.initials: M
authors.lastname: Modat
authors.forename: Simon
authors.initials: S
authors.lastname: Arridge
authors.forename: Helen
authors.initials: H
authors.lastname: Grimes
authors.forename: Derek
authors.initials: D
authors.lastname: D'Souza
authors.forename: David
authors.initials: D
authors.lastname: Thomas
authors.forename: Dylan O'
authors.initials: DO
authors.lastname: Connell
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Low
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kaza
authors.forename: David J
authors.initials: DJ
authors.lastname: Collins
authors.forename: Martin O
authors.initials: MO
authors.lastname: Leach
authors.forename: David J
authors.initials: DJ
authors.lastname: Hawkes
mesh_terms: D000465:Algorithms; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D009068:Movement; D019047:Phantoms, Imaging; D012119:Respiration