title: Knee symptoms among adults at risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative.
abstract: The purpose of this study was to examine if adults who develop accelerated knee osteoarthritis (KOA) have greater knee symptoms with certain activities than those with or without incident common KOA. We conducted a case-control study using data from baseline and the first four annual visits of the Osteoarthritis Initiative. Participants had no radiographic KOA at baseline (Kellgren-Lawrence (KL) <2). We classified 3 groups as follows: (1) accelerated KOA: > = 1 knee developed advance-stage KOA (KL = 3 or 4) within 48 months, (2) common KOA: > = 1 knee increased in radiographic severity (excluding those with accelerated KOA), and (3) no KOA: no change in radiographic severity by 48 months. We focused on individual items from the WOMAC pain/function subscales and KOOS pain/symptoms subscales. The index visit was a year before a person met the definition for accelerated, common, or no KOA. To examine group difference in knee symptoms, we used ordinal logistic regression models for each symptom. Results are reported as odds ratios (OR) and 95% confidence intervals (CI). Individuals who developed accelerated KOA were more likely to report greater difficulty with lying down (OR = 2.10, 95% CI = 1.04 to 4.25), pain with straightening the knee fully (OR = 2.04, 95% CI = 1.08, 3.85), and pain walking (OR = 2.49, 95% CI = 1.38, 4.84) than adults who developed common KOA. Individuals who develop accelerated KOA report greater symptoms with certain activities than those with common KOA. Our results may help identify individuals at risk for accelerated KOA or with early-stage accelerated KOA.
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA, 02111, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Davis
authors.affiliation: Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Eaton
authors.affiliation: Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence Michael E. DeBakey VAMC, Houston, TX, USA.|Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Grace H
authors.initials: GH
authors.lastname: Lo
authors.affiliation: Division of Rheumatology, Immunology & Allergy, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Bing
authors.initials: B
authors.lastname: Lu
authors.affiliation: The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.|Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.
authors.forename: Lori Lyn
authors.initials: LL
authors.lastname: Price
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA, 02111, USA.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: McAlindon
authors.affiliation: Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Barbe
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA, 02111, USA. jeffrey.driban@tufts.edu.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Driban
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020370:Osteoarthritis, Knee / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D010147:Pain Measurement / Q000379:methods*; D012372:ROC Curve; D011859:Radiography / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index; D014481:United States / Q000453:epidemiology
keywords: Methodology; OA; Observational studies; Pain; Rheumatic diseases; Specialty fields