title: GHetting to know ADPKD proliferative signaling, STAT.
abstract: Due to their common pathogenesis and parallel proliferative signaling pathways, the cystic diseases have been recently studied in the context of cancer biology. The present study continues this paradigm by identifying signal transducer and activator of transcription (STAT5) and growth hormone (GH) as potentially modifiable pathways in polycystic kidney disease. GH, which is a potent activator of STAT5, has the additional possibility of being a biomarker, as well as providing a potential mechanism of action of somatostatin analogs in clinical trials.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of California, Davis, California.
authors.forename: Ching-Hsien
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of California, Davis, California; Cancer Center, University of California, Davis, California; Medical Service, Sacramento VA Medical Center, Sacramento, California. Electronic address: rhweiss@ucdavis.edu.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Weiss
mesh_terms: D013006:Growth Hormone; D006801:Humans; D016891:Polycystic Kidney, Autosomal Dominant; D050799:STAT5 Transcription Factor; D015398:Signal Transduction
chemical_list: D050799:STAT5 Transcription Factor; D013006:Growth Hormone