title: Serous Tubal Intraepithelial Carcinoma Associated With Extraovarian Metastases.
abstract: The evolving knowledge of ovarian carcinogenesis sets the stage for our understanding of high-grade serous pelvic carcinoma (HGSC). Findings in prophylactic surgery introduced serous tubal intraepithelial carcinoma (STIC) as potential precursor of HGSC. The present study explores whether STIC instead should already be considered as an early stage of HGSC with a need for comprehensive staging and therapy.
  
  
  
  We identified all consecutive patients with HGSC who received first-line therapy in our referral center for gynecologic oncology from January 2011 to April 2016. All chemo-naive patients with upfront debulking surgery in whom an association of STIC and tumor lesions could be analyzed were included. Patients with previous removal of the adnexa or overgrown of the fallopian tube by the tumor were excluded. Pathological workup of the fallopian tubes according to the SEE-FIM protocol was conducted.
  
  
  
  We analyzed a series of 231 consecutive patients with HGSC of whom 121 (52.4%) had ovarian cancer, 74 (32.0%) had cancer of the fallopian tubes and 36 patients (15.6%) had primary peritoneal cancer. Serous tubal intraepithelial carcinoma could be identified in 158 (68.4%) of 231 patients; of 22 patients, 28.1% is ovarian cancer, 30.8% cancer of the fallopian tubes, and 9.5% peritoneal cancer. Four patients without any further intra-abdominal disease were identified of whom 2 patients had stage FIGO IA and 2 patients had lymph node metastases only.
  
  
  
  Our data suggest that STIC should be regarded as a malignant lesion with metastatic potential. Therefore, we recommend a comprehensive surgical staging including lymphadenectomy.
authors.affiliation: *Department of Gynecology and Gynecologic Oncology, Evangelische Huyssens-Stiftung, †Center for Pathology, Kliniken Essen-Mitte, Essen, Germany; and ‡Department of Gynecology and Gynecologic Oncology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Schneider
authors.forename: Sebastian
authors.initials: S
authors.lastname: Heikaus
authors.forename: Philipp
authors.initials: P
authors.lastname: Harter
authors.forename: Florian
authors.initials: F
authors.lastname: Heitz
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Beyhan
authors.initials: B
authors.lastname: Ataseven
authors.forename: Sonia
authors.initials: S
authors.lastname: Prader
authors.forename: Christian
authors.initials: C
authors.lastname: Kurzeder
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebel
authors.forename: Alexander
authors.initials: A
authors.lastname: Traut
authors.forename: Andreas
authors.initials: A
authors.lastname: du Bois
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D063646:Carcinogenesis; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D018284:Cystadenocarcinoma, Serous / Q000473:pathology* / Q000601:surgery; D005185:Fallopian Tube Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D055815:Young Adult