title: MiR-30 Family Potentially Targeting PI3K-SIAH2 Predicted Interaction Network Represents a Novel Putative Theranostic Panel in Non-small Cell Lung Cancer.
abstract: Non-small cell lung cancer (NSCLC) comprises about 84% of all lung cancers. Many treatment options are available but the survival rate is still very low due to drug resistance. It has been found that phosphoinositide-3-kinase (PI3K) affects sensitivity to tyrosine kinase inhibitors (TKIs), including gefitinib and erlotinib. Expression level of seven in absentia homolog 2 (SIAH2), an E3 ubiquitin-protein ligase, is upregulated in NSCLC and correlated with tumor grade. However, the relationship between PI3K and SIAH2 remains unclear and therefore it is not known whether they can act as treatment co-targets and theranostic dual markers for overcoming TKI resistance. It is worthy to note that PI3K and SIAH2 are potentially regulated by a common group of microRNAs in miR-30 family. Our bioinformatics analyses showed upregulated SIAH2 expression in NSCLC based on mass spectrometry data, explored its indirect interaction with PI3K and predicted their targeting microRNAs in common. We have also explored the potential role of miR-30 family in the modulation of PI3K-SIAH2 interaction in NSCLC.
authors.affiliation: Department of Health Technology and Informatics, Hong Kong Polytechnic University Hong Kong, Hong Kong.
authors.forename: Lawrence W C
authors.initials: LW
authors.lastname: Chan
authors.affiliation: Department of Health Technology and Informatics, Hong Kong Polytechnic University Hong Kong, Hong Kong.
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Health Technology and Informatics, Hong Kong Polytechnic University Hong Kong, Hong Kong.
authors.forename: Fei
authors.initials: F
authors.lastname: Meng
authors.affiliation: Department of Health Technology and Informatics, Hong Kong Polytechnic University Hong Kong, Hong Kong.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Health Technology and Informatics, Hong Kong Polytechnic University Hong Kong, Hong Kong.
authors.forename: Sze Chuen Cesar
authors.initials: SC
authors.lastname: Wong
authors.affiliation: Hong Kong Adventist Hospital Hong Kong, Hong Kong.
authors.forename: Joseph S K
authors.initials: JS
authors.lastname: Au
authors.affiliation: ABSL-3 Laboratory at the Center for Animal Experiment and State Key Laboratory of Virology, School of Medicine, Institute of Animal Model for Human Diseases, Wuhan University Wuhan, China.
authors.forename: Sijun
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Clinical Oncology, Queen Elizabeth Hospital Hong Kong, Hong Kong.
authors.forename: William C S
authors.initials: WC
authors.lastname: Cho
keywords: PI3K; SIAH2; microRNA; non-small cell lung cancer; theranostics