title: Whether preventive low dose magnesium sulphate infusion has an influence on postoperative pain perception and the level of serum beta-endorphin throughout the total abdominal hysterectomy.
abstract: OBJECTIVE
  Due to the known role of preventive low dose magnesium sulphate on postoperative pain management, in this randomized, double-blinded, placebo-controlled study, we tried to investigate the possible relationship between low dose intra-operative magnesium sulphate infusion, postoperative analgesia and the level of serum beta-endorphin during total abdominal hysterectomy under general anesthesia.
  
  
  METHODS
  Forty women undergoing total abdominal hysterectomy were randomly allocated into 2 groups (20 in each arm). Fifteen minutes before induction of anaesthesia, the case group received a continuous intravenous infusion of magnesium sulphate (15mg/kg/h) and placebo control group received the same volume of isotonic saline. Pain scores were assessed at 0, 6, 12, and 24h after operations using Verbal Numeric Rating Scale. Pethidine consumption was recorded precisely. Serum level of beta-endorphin just 15min before the induction and at the end of the operations was determined by ELISA technique.
  
  
  RESULTS
  At 6 and 12h after the operations, Verbal Numeric Rating Scale in the case group was significantly lower than that of placebo control group (P=.0001). Over 24h after the operations, pethidine consumption was significantly lower in the case group compared with control group (P=.0001). In the case group, serum level of beta-endorphin was significantly decreased at the end of the operations compared with before the induction (P=.04).
  
  
  CONCLUSIONS
  We illustrated that preventive low dose intra-operative magnesium sulphate infusion reduces postoperative pain, has opioid sparing effect and declines serum beta-endorphin concentration during total abdominal hysterectomy.
authors.affiliation: Department of Anesthesiology, Reproductive Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: K
authors.initials: K
authors.lastname: Haryalchi
authors.affiliation: Department of Physiology, Medical Biotechnology Research Center, Faculty of Paramedical Sciences, Guilan University of Medical Science, Rasht, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Abedinzade
authors.affiliation: Department of Clinical Biochemistry, Medical Biotechnology Research Center, Faculty of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: khanaki@gums.ac.ir.
authors.forename: K
authors.initials: K
authors.lastname: Khanaki
authors.affiliation: Department of Gynaecology, Reproductive Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Mansour Ghanaie
authors.affiliation: Bachelor of Science, Department of Anesthesiology, Reproductive Health Research Center, Faculty of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Mohammad Zadeh
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D059026:Diagnostic Self Evaluation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008875:Middle Aged; D010149:Postoperative Pain / Q000097:blood* / Q000175:diagnosis / Q000517:prevention & control*; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D000700:Analgesics; D001615:beta-Endorphin; D008278:Magnesium Sulfate
keywords: Beta-endorfinas séricas; Histerectomía abdominal total; Magnesium sulphate; Postoperative pain management; Serum beta-endorphin; Sulfato de magnesio; Total abdominal hysterectomy; Tratamiento del dolor postoperatorio