title: Stress-induced O-GlcNAcylation: an adaptive process of injured cells.
abstract: In the 30 years, since the discovery of nucleocytoplasmic glycosylation,O-GlcNAc has been implicated in regulating cellular processes as diverse as protein folding, localization, degradation, activity, post-translational modifications, and interactions. The cell co-ordinates these molecular events, on thousands of cellular proteins, in concert with environmental and physiological cues to fine-tune epigenetics, transcription, translation, signal transduction, cell cycle, and metabolism. The cellular stress response is no exception: diverse forms of injury result in dynamic changes to theO-GlcNAc subproteome that promote survival. In this review, we discuss the biosynthesis ofO-GlcNAc, the mechanisms by whichO-GlcNAc promotes cytoprotection, and the clinical significance of these data.
authors.affiliation: Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205-2185, U.S.A.
authors.forename: Marissa R
authors.initials: MR
authors.lastname: Martinez
authors.affiliation: Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205-2185, U.S.A.|Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, 14049-900 SP, Brazil.
authors.forename: Thiago Braido
authors.initials: TB
authors.lastname: Dias
authors.affiliation: Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205-2185, U.S.A.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Natov
authors.affiliation: Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205-2185, U.S.A. nzachara@jhmi.edu.
authors.forename: Natasha E
authors.initials: NE
authors.lastname: Zachara
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D002470:Cell Survival; D006031:Glycosylation; D006801:Humans; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D000117:Acetylglucosamine
keywords: OGT; chaperone; glycoprotein; heat shock response; mgea5; signal transduction