title: Structure and function of HWE/HisKA2-family sensor histidine kinases.
abstract: Sensor histidine kinases regulate adaptive cellular responses to changes in the chemical or physical state of the environment. HWE/HisKA2-family kinases comprise a subset of histidine kinases that is defined by unique sequence motifs in both the catalytic and non-catalytic regions. Recent crystal structures have defined conserved intramolecular interactions that inform models of kinase regulation that are unique to the HWE/HisKA2 superfamily. Emerging genetic, biochemical and genomic data indicate that, unlike typical histidine kinases, HWE/HisKA2 kinases do not generally signal via classical DNA-binding response regulators. Rather, these unusual kinases are often part of atypical regulatory pathways that control changes in gene expression via modulation of protein-protein interactions or transcription anti-termination.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
authors.forename: Julien
authors.initials: J
authors.lastname: Herrou
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA; Department of Microbiology, University of Chicago, Chicago, IL, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Crosson
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. Electronic address: amfiebig@uchicago.edu.
authors.forename: Aretha
authors.initials: A
authors.lastname: Fiebig
mesh_terms: D020561:Alphaproteobacteria / Q000201:enzymology / Q000378:metabolism; D001105:Archaea / Q000201:enzymology / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006094:Gram-Positive Bacteria / Q000201:enzymology / Q000378:metabolism; D000071677:Histidine Kinase / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D000071677:Histidine Kinase