title: Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025.
abstract: Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungusPenicillium brevicompactumDFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of1and2were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound9showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC50value of 15.6 μM. In addition,3and5had significant antifouling activity againstBugula neritinalarval settlement with EC50values of 13.7 and 22.6 μM, respectively. The NMR data of6,8, and9were assigned for the first time.
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. xuxinya@scsio.ac.cn.
authors.forename: Xinya
authors.initials: X
authors.lastname: Xu
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. zhangxiaoyong@scsio.ac.cn.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. xhnong@scsio.ac.cn.
authors.forename: Xuhua
authors.initials: X
authors.lastname: Nong
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. wangjielangjing@126.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. shuhuaqi@scsio.ac.cn.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Qi
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry*; D057219:Biofouling; D002013:Bryozoa / Q000187:drug effects; D002942:Circular Dichroism; D045325:HCT116 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D009173:Mycophenolic Acid / Q000031:analogs & derivatives*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D026121:Indole Alkaloids; D009173:Mycophenolic Acid
keywords: Brevianamide; Mycochromenic acid derivative; Penicillium brevicompactum; antifouling; cytotoxicity