title: Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross-sectional retrospective study.
abstract: BACKGROUND
  Current information indicates that psoriasis is a metabolic disorder with systemic manifestations. Reports have revealed an association between psoriasis and several chronic autoimmune disorders. For one of these disorders, Hashimoto's thyroiditis (HT), there are scarce, and relatively unconfirmed, reports of an association with psoriasis. We sought to determine if such an association is detectable in a large medical record data repository.
  
  
  METHODS
  We searched one institution's electronic medical record data repository from January 2010 to December 2013. Patients were identified by ICD-9 codes (psoriasis: 696.0; 696.1, HT: 245.2). Only data from patients with laboratory-confirmed HT (anti-thyroid peroxidase [anti-TPO] antibodies; thyroglobulin antibodies; serum thyroid-stimulating hormone; and free T3) were eligible for inclusion. Logistic regression analysis was used to obtain an odds ratio (OR) to establish an association between psoriasis and HT. Stratified analyses were performed to test for confounding variable and effect modification.
  
  
  RESULTS
  Medical records for 856,615 individuals with documented encounters between January 1, 2010, and December 31, 2013, were detected. A total of 9654 had a diagnosis of psoriasis, and 1745 had a diagnosis of HT. Of these, 41 subjects were diagnosed with both conditions. A significant association existed for psoriasis and HT, even after adjusting for confounding variables that included gender, age, psoriatic arthropathy, and the use of systemic anti-psoriatic agents (OR = 2.49; 95% CI 1.79-3.48; P < 0.0001).
  
  
  CONCLUSIONS
  This association has broad clinical impact and deserves further attention with regard to patient care, clinical research, and developmental therapeutics.
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Kiguradze
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Finola M
authors.initials: FM
authors.lastname: Bruins
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Guido
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Tanya
authors.initials: T
authors.lastname: Bhattacharya
authors.affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Alfred
authors.initials: A
authors.lastname: Rademaker
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Aleksandra G
authors.initials: AG
authors.lastname: Florek
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Alba
authors.initials: A
authors.lastname: Posligua
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Shatil
authors.initials: S
authors.lastname: Amin
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Laumann
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Dennis P
authors.initials: DP
authors.lastname: West
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nardone
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000453:epidemiology*; D012189:Retrospective Studies; D013972:Thyrotropin / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D014284:Triiodothyronine; D013972:Thyrotropin; D007453:Iodide Peroxidase