title: Topotactic Conversion of α-Fe2O3Nanowires into FeP as a Superior Fluorosensor for Nucleic Acid Detection: Insights from Experiment and Theory.
abstract: Nanostructures possess distinct quenching ability toward fluorophores with different emission frequencies and have been intensively used as nanoquenchers for homogeneous nucleic acid detection. Complete understanding of such a sensing system will provide significant guidance for the design of superior sensing materials, which is still lacking. In this Letter, we demonstrate the development of FeP nanowires as a nanoquencher for high-performance fluorescent nucleic acid detection with much superior performance to α-Fe2O3counterparts. The whole detection process is complete within 1 min, and this fluorosensor presents a detection limit as low as 4 pM with strong discrimination of single-point mutation. Electrochemical tests and density functional theory calculations reveal that FeP NWs are superior in both conductivity for facilitated electron diffusion and hydrogen-evolving catalytic activity for favorable electron depletion, providing further experimental and theoretical insights into the enhanced sensing performance of the FeP nanosensor. Both faster electron transfer kinetics and stronger electron-consuming ability via catalyzed proton reduction enable FeP nanowires to be a superb nucleic acid nanosensor for applications.
authors.affiliation: College of Chemistry, Sichuan University , Chengdu, Sichuan 610064, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: College of Chemistry, Sichuan University , Chengdu, Sichuan 610064, China.
authors.forename: Danni
authors.initials: D
authors.lastname: Liu
authors.affiliation: College of Chemistry, Sichuan University , Chengdu, Sichuan 610064, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Hao
authors.affiliation: College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu, Shandong 273165, China.
authors.forename: Fengli
authors.initials: F
authors.lastname: Qu
authors.affiliation: College of Chemistry, Sichuan University , Chengdu, Sichuan 610064, China.|Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences , Ningbo, Zhejiang 315201, China.
authors.forename: Ruixiang
authors.initials: R
authors.lastname: Ge
authors.affiliation: Analytical and Test Center, Southwest University of Science and Technology , Mianyang, Sichuan 621010, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Chengdu Institute of Geology and Mineral Resources , Chengdu, Sichuan 610081, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Du
authors.affiliation: Chemistry Department, King Abdulaziz University , Jeddah, Makkah 21589, Saudi Arabia.
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Asiri
authors.affiliation: Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences , Ningbo, Zhejiang 315201, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: College of Chemistry, Sichuan University , Chengdu, Sichuan 610064, China.
authors.forename: Xuping
authors.identifier: 0000-0001-5034-1135
authors.initials: X
authors.lastname: Sun