title: Significance of Cholinergic and Peptidergic Nerves in Stress-Induced Ulcer and MALT Lymphoma Formation.
abstract: Backgound: The role of enteric nerves has previously been demonstrated in the formation of several gastric diseases. In the present review, the significance of the cholinergic nerves in stress-induced ulcer formation as well as the importance of substance P in the formation of gastric MALT lymphoma is discussed.
  
  
  
  The stress-induced ulcer was induced by the plaster bandage methods in rats. The gastric MALT lymphoma was formed by the peroral infection of gastric mucosal homogenate of the infected mouse in C57BL/6 mice. For the stress-induced ulcer, the distribution of the cholinergic nerves and muscarinic acetylcholine receptors was investigated by acetylcholinesterase histochemistry and autoradiography of water soluble compounds using 3H-quinuclidinyl benzilate was performed. To the MALT lymphoma study, the distribution of the substance P and effect of substance P antagonist, spantide II, was investigated by immunohistochemical studies.
  
  
  
  The stress induced ulcer formation was shown to be related to the hyperactivity of the cholinergic nerves. The gastric MALT lymphoma was shown to be related to the increased localization of substance P.
  
  
  
  Stress-induced ulceration as a model of hyperactivity of the cholinergic nerves was proved to be a useful approach, while substance P and its role in MALT lymphoma formation may serve as a tool to clarify the neuroimmune modulation of chronic infectious diseases.
authors.affiliation: School of Pharmacy, Kitasato University, Tokyo 108-8641. Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: School of Pharmacy, Kitasato University, Tokyo 108-8641. Japan.
authors.forename: Anders
authors.initials: A
authors.lastname: Overby
authors.affiliation: School of Pharmacy, Kitasato University, Tokyo 108-8641. Japan.
authors.forename: Akina
authors.initials: A
authors.lastname: Uehara
authors.affiliation: Organized Center of Clinical Medicine, Sanno Medical Center, International University of Health and Welfare, Tokyo 107-0052. Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.affiliation: 3rd Department of Internal Medicine, Kyorin University, Mitaka 181-0004. Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Laboratory of Molecular Cell Biology, School of Pharmacy, Nihon University, Funabashi, Chiba 274- 8555. Japan.
authors.forename: Somay Y
authors.initials: SY
authors.lastname: Murayama
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Tokyo 108-8641. Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Matsui
mesh_terms: D000110:Acetylcholinesterase / Q000494:pharmacology; D000818:Animals; D059329:Cholinergic Neurons / Q000187:drug effects / Q000648:ultrastructure; D005725:Ganglia, Autonomic / Q000502:physiology* / Q000648:ultrastructure; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D013270:Stomach / Q000294:innervation*; D013274:Stomach Neoplasms / Q000209:etiology* / Q000648:ultrastructure; D013276:Stomach Ulcer / Q000209:etiology*; D013312:Stress, Physiological; D013373:Substance P / Q000494:pharmacology
chemical_list: D013373:Substance P; D000110:Acetylcholinesterase
keywords: Gastric ulcer; NK-1R; acetylcholinesterase; autoradiography; gastric MALT lymphoma; substance P