title: 211Rn/211At and209At production with intense mass separated Fr ion beams for preclinical211At-based α-therapy research.
abstract: Mass-separated francium beams (211Fr or213Fr) were implanted into solid targets for producing211Rn (14.6h half-life) or209At (5.41h), in situ.211Rn was transferred to dodecane and isolated from contaminants, providing sources for211At (7.21h) production by211Rn decay (73%).209At was recovered with high radionuclidic purity in aqueous solutions, directly. These experiments demonstrated Fr beam implantations as a novel method for producing preclinical quantities of211Rn/211At (for therapy) and209At (for imaging).
authors.affiliation: TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada; Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Road, Victoria, British Columbia, V8P 5C2, Canada.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Crawford
authors.affiliation: TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Kunz
authors.affiliation: TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Schaffer
authors.affiliation: TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada; Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Road, Victoria, British Columbia, V8P 5C2, Canada.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Ruth
mesh_terms: D001246:Astatine / Q000737:chemistry* / Q000627:therapeutic use; D003952:Diagnostic Imaging / Q000379:methods; D005605:Francium / Q000737:chemistry*; D006207:Half-Life; D008970:Molecular Weight; D011886:Radon / Q000737:chemistry*; D012996:Solutions; D014867:Water
chemical_list: D012996:Solutions; D014867:Water; D005605:Francium; D011886:Radon; D001246:Astatine
keywords: At-209; At-211; ISOL-technique, rare isotope beam; astatine-209; astatine-211; francium; generator system; ion implantation; radioisotope production; radon-211; targeted alpha therapy