title: Methyl Jasmonate Ameliorates Testosterone Propionate-induced Prostatic Hyperplasia in Castrated Wistar Rats.
abstract: Benign prostate hyperplasia (BPH) is a progressive disease that is related to age. Known therapeutic agents used in the treatment of BPH are associated with toxicity. Therefore, chemoprevention could be an effective approach. We investigated the ameliorative effects of methyl jasmonate (MeJA) in testosterone propionate (TP)-induced BPH in castrated rats. Castration was performed by removing both testes through the scrotum sack under ketamine anesthesia. Rats were assigned into seven groups of seven animals each: non-castrated control, castrated control, castrated rats that received TP, castrated rats that received TP and MeJA, castrated rats that received TP and finasteride, castrated rats that received MeJA, and castrated rats that received finasteride. Results indicate that BPH rats had significantly (p < 0.05) elevated prostate weight and relative weight of prostate relative to control. Also, BPH rats had significantly (p < 0.05) increased activities of prostatic acid and alkaline phosphatases, levels of zinc, and malondialdehyde. Further, levels of enzymic and non-enzymic antioxidative indices were significantly (p < 0.05) reduced in BPH. Histology of prostate revealed hyperplasia of transition lobe, increased expression of PSA, and Ki67 in BPH. Treatment with MeJA and finasteride attenuated the activities of the phosphatases and levels of antioxidants in BPH. Overall, MeJA ameliorates BPH via antioxidative mechanism. Copyright © 2017 John Wiley & Sons, Ltd.
authors.affiliation: Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: Olubukola Oyebimpe
authors.initials: OO
authors.lastname: Akanni
authors.affiliation: Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: Olusoji John
authors.initials: OJ
authors.lastname: Abiola
authors.affiliation: Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: Oluwatosin Adekunle
authors.identifier: http://orcid.org/0000-0001-9960-6763
authors.initials: OA
authors.lastname: Adaramoye
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000818:Animals; D003517:Cyclopentanes / Q000737:chemistry*; D006801:Humans; D008297:Male; D054883:Oxylipins / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000737:chemistry*; D043343:Testosterone Propionate / Q000737:chemistry*
chemical_list: D000085:Acetates; D003517:Cyclopentanes; D054883:Oxylipins; D010936:Plant Extracts; D013739:Testosterone; C072239:methyl jasmonate; D043343:Testosterone Propionate
keywords: benign prostate hyperplasia; methyl jasmonate; oxidative stress; prostate-specific antigen