title: Vibrational analysis of implants and tissues: Calibration and mechanical spectroscopy of multi-component materials.
abstract: Several new methods have been used to non-destructively evaluate the mechanical properties of materials and tissues including magnetic resonance elastography, ultrasound elastography, optical coherence elastography, and various forms of vibrational analysis. One of the limitations of using these methods is the need to establish a relationship between the modulus measured using each new technique and moduli measured using well-established techniques such as constant rate-of-strain and incremental stress-strain curves. In addition, there are no available methods for analyzing the mechanical properties of the individual components of multi-component materials. In this article, we present data showing that there is a strong correlation (correlation coefficient >0.9) between the modulus measured using classical uniaxial tensile incremental stress-strain tests and those made using a combination of optical coherence tomography and vibrational analysis. Beyond this, we demonstrate that the moduli of the major structural components of pig skin can be measured using this technique. These results suggest that optical coherence tomography in concert with vibrational analysis can be used to measure the moduli of biological and implant materials without having to determine Poisson's ratio. In addition, each of the moduli of the major fibrous components of pig skin can be measured concurrently using this technique. These results may be useful in the characterization of synthetic implants and tissue derived materials without requiring removal of one or more components that are to be characterized. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1666-1671, 2017.
authors.affiliation: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
authors.forename: Ruchit G
authors.initials: RG
authors.lastname: Shah
authors.affiliation: Division of Biomaterials, DV Consulting Services, 3 Warwick Drive, Chelmsford, Massachusetts.
authors.forename: Dale
authors.initials: D
authors.lastname: DeVore
authors.affiliation: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Pierce
authors.affiliation: Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey.
authors.forename: Frederick H
authors.initials: FH
authors.lastname: Silver
mesh_terms: D062088:Acellular Dermis; D000818:Animals; D002138:Calibration; D020405:Dermis / Q000737:chemistry*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods; D006801:Humans; D008422:Materials Testing; D019736:Prostheses and Implants; D012825:Silicon / Q000737:chemistry*; D013314:Stress, Mechanical; D013552:Swine; D013718:Tensile Strength; D041623:Tomography, Optical Coherence / Q000379:methods
chemical_list: D012825:Silicon
keywords: dermis; elastography; mechanical properties; modulus; optical coherence tomography; skin; tissue; vibrational analysis