title: The Secrets of Acinetobacter Secretion.
abstract: Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II secretion system (T2SS), a type VI secretion system (T6SS), autotransporter, and outer membrane vesicles (OMVs). In this review, we summarize the current knowledge of secretion systems in Acinetobacter species, and highlight their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogens.
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Brent S
authors.initials: BS
authors.lastname: Weber
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Kinsella
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Harding
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: mariofeldman@wustl.edu.
authors.forename: Mario F
authors.initials: MF
authors.lastname: Feldman
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology / Q000503:physiopathology; D040981:Acinetobacter baumannii / Q000378:metabolism* / Q000472:pathogenicity; D001425:Bacterial Outer Membrane Proteins; D000069178:Type II Secretion Systems; D000069320:Type V Secretion Systems; D000069376:Type VI Secretion Systems
chemical_list: D001425:Bacterial Outer Membrane Proteins; D000069178:Type II Secretion Systems; D000069320:Type V Secretion Systems; D000069376:Type VI Secretion Systems
keywords: Acinetobacter; Autotransporters; Outer membrane vesicle; Secretion systems; T2SS; T6SS