title: Prognostic markers in metastatic cutaneous squamous cell carcinoma of the head and neck.
abstract: The minority of head and neck cutaneous squamous cell carcinomas (SCC) metastasize to regional lymph nodes. The purpose of this study was to describe the clinical outcomes and prognostic factors for patients with node-positive head and neck cutaneous SCC who underwent lymphadenectomy.
  
  
  
  We conducted a retrospective single center study using the Kaplan-Meier method for the investigation of the overall survival (OS) and locoregional control rates. The Cox proportional hazards model was evaluated to identify prognostic factors.
  
  
  
  The median number of positive lymph nodes from 149 lymphadenectomies was 2 in the neck and 1 in the parotid gland. The 5-year OS and locoregional control rates were 50% and 77%, respectively. OS was worse among older patients (hazard ratio [HR], 1.04; p = .015), immunosuppressed patients (HR, 2.06; p = .034), and patients with a high total lymph node ratio (calculated from the number of positive lymph nodes divided by the total number of nodes; multivariate analysis [MVA]; HR, 1.13; p = .019).
  
  
  
  Low total lymph node ratio is associated with improved outcomes in node-positive head and neck cutaneous SCC. © 2017 Wiley Periodicals, Inc. Head Neck 39: 772-778, 2017.
authors.affiliation: Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Nir
authors.initials: N
authors.lastname: Hirshoren
authors.affiliation: Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Julia
authors.initials: J
authors.lastname: Danne
authors.affiliation: Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.|Department of Surgery, University of Melbourne, Melbourne, Australia.
authors.forename: Benjamin John
authors.initials: BJ
authors.lastname: Dixon
authors.affiliation: Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Matthew
authors.initials: M
authors.lastname: Magarey
authors.affiliation: Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Kleid
authors.affiliation: Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Angela
authors.initials: A
authors.lastname: Webb
authors.affiliation: Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Albert
authors.initials: A
authors.lastname: Tiong
authors.affiliation: Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: June
authors.initials: J
authors.lastname: Corry
authors.affiliation: Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.|Department of Surgery, University of Melbourne, Melbourne, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Gyorki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001315:Australia; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision / Q000379:methods*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor
keywords: cutaneous squamous cell carcinoma; head and neck; lymph node ratio; prognostic parameters; radiation