title: Cancer Clinical Trials: The Rear-View Mirror and the Crystal Ball.
abstract: Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes in clinical trials' design and conduct, and we forecast future directions toward personalized and global impact.
authors.affiliation: Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1Z5, Canada.
authors.forename: Dave
authors.initials: D
authors.lastname: Cescon
authors.affiliation: Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1Z5, Canada. Electronic address: lillian.siu@uhn.ca.
authors.forename: Lillian L
authors.initials: LL
authors.lastname: Siu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D035843:Biomedical Research; D002986:Clinical Trials as Topic; D017277:Drug Approval; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D012107:Research Design
chemical_list: D000970:Antineoplastic Agents