title: The Effects ofPunica granatumFlower Extract on Skin Injuries Induced by Burn in Rats.
abstract: Background. We compared the efficacy ofP. granatum(P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats.Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10%Punica granatumflower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content inP. granatumextract was determined.Results. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containingP. granatumextract than in rats treated with cream containing SSD (2.8 ± 0.9 cm2versus 8.4 ± 3.2 cm2). The wounds completely healed on day 25 of the treatment in rats treated with creams containingP. granatumflower extract compared with those in rats treated with the other agents.Conclusion. These results indicated thatP. granatumflower extract promoted wound healing in rats and could be used for managing burn injuries.
authors.affiliation: Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Nasiri
authors.affiliation: Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Seyed Jalal
authors.identifier: 0000-0001-8055-8036
authors.initials: SJ
authors.lastname: Hosseinimehr
authors.affiliation: Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Akbari
authors.affiliation: Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Azadbakht
authors.affiliation: Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Soheil
authors.initials: S
authors.lastname: Azizi