title: [State of the art in fluid and volume therapy : A user-friendly staged concept].
abstract: Adequate fluid therapy is highly important for the perioperative outcome of our patients. Both, hypovolemia and hypervolemia can lead to an increase in perioperative complications and can impair the outcome. Therefore, perioperative infusion therapy should be target-oriented. The main target is to maintain the patient's preoperative normovolemia by using a sophisticated, rational infusion strategy.Perioperative fluid losses should be discriminated from volume losses (surgical blood loss or interstitial volume losses containing protein). Fluid losses as urine or perspiratio insensibilis (0.5-1.0 ml/kg/h) should be replaced by balanced crystalloids in a ratio of 1:1. Volume therapy step 1: Blood loss up to a maximum value of 20% of the patient's blood volume should be replaced by balanced crystalloids in a ratio of 4(-5):1. Volume therapy step 2: Higher blood losses should be treated by using iso-oncotic, preferential balanced colloids in a ratio of 1:1. For this purpose hydroxyethyl starch can also be used perioperatively if there is no respective contraindication, such as sepsis, burn injuries, critically ill patients, renal impairment or renal replacement therapy, and severe coagulopathy. Volume therapy step 3: If there is an indication for red cell concentrates or coagulation factors, a differentiated application of blood and blood products should be performed.
authors.affiliation: Klinik für Anaesthesiologie, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland. markus.rehm@med.uni-muenchen.de.
authors.forename: M
authors.initials: M
authors.lastname: Rehm
authors.affiliation: Klinik für Anaesthesiologie, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Hulde
authors.affiliation: Klinik für Anaesthesiologie, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Kammerer
authors.affiliation: Klinik für Anaesthesiologie, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland.
authors.forename: A S
authors.initials: AS
authors.lastname: Meidert
authors.affiliation: Klinik für Anaesthesiologie, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Hofmann-Kiefer
mesh_terms: D001802:Blood Substitutes / Q000008:administration & dosage / Q000627:therapeutic use*; D003422:Critical Care; D000077324:Crystalloid Solutions; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D020896:Hypovolemia / Q000628:therapy*; D007552:Isotonic Solutions / Q000627:therapeutic use; D019990:Perioperative Care / Q000379:methods*
chemical_list: D001802:Blood Substitutes; D000077324:Crystalloid Solutions; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions
keywords: Colloid; Crystalloid; Hydroxyethyl starch; Infusions; Perioperative volume balance