title: Safety of measles-containing vaccines in post-marketing surveillance in Anhui, China.
abstract: The safety of measles vaccination is of great interest and importance to public health practice and the general society. We have analyzed the adverse events following immunization (AEFIs) of currently used measles-containing vaccines (including live attenuated measles vaccine, live attenuated measles and rubella combined vaccine, live attenuated measles and mumps combined vaccine, live attenuated Measles, Mumps and Rubella Combined Vaccine) in Anhui Province, China. From 2009 to 2014, 9.9 million doses of measles-containing vaccines were administrated and 1893 AEFIs were found (191.4 per million doses), of which, 33 serious AEFIs (3.3 per million vaccine doses) were reported. 59.4% (1124 cases) were male cases, and 85.1% (1611 cases) occurred in persons aged < 1 year. 93.3% (1766 cases) occurred at the first dose of vaccination and 95.9% (1815 cases) were found within 3 days after vaccination. This study presents up-to-date data and suggests that the measles-containing vaccines used in Anhui Province of China are safe.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.|The Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, Anhui, China.|Department of Immunization and Prevention, Anhui Center for Disease Control and Prevention, Hefei, Anhui, China.
authors.forename: Fan-Ya
authors.initials: FY
authors.lastname: Meng
authors.affiliation: Department of Immunization and Prevention, Anhui Center for Disease Control and Prevention, Hefei, Anhui, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Immunization and Prevention, Anhui Center for Disease Control and Prevention, Hefei, Anhui, China.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Shen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.|The Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, Anhui, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.affiliation: Department of Immunization and Prevention, Anhui Center for Disease Control and Prevention, Hefei, Anhui, China.
authors.forename: Ji-Hai
authors.initials: JH
authors.lastname: Tang
authors.affiliation: Department of Immunization and Prevention, Anhui Center for Disease Control and Prevention, Hefei, Anhui, China.
authors.forename: Bin-Bing
authors.initials: BB
authors.lastname: Wang
authors.affiliation: Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.|The Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, Anhui, China.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data; D000707:Anaphylaxis / Q000209:etiology; D044466:Asian People; D002681:China; D064420:Drug-Related Side Effects and Adverse Reactions / Q000145:classification / Q000208:ethnology / Q000209:etiology; D004660:Encephalitis / Q000209:etiology; D006801:Humans; D007114:Immunization / Q000009:adverse effects / Q000379:methods*; D008457:Measles / Q000208:ethnology / Q000276:immunology* / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology* / Q000592:standards; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology / Q000592:standards; D011358:Product Surveillance, Postmarketing / Q000379:methods* / Q000592:standards; D012640:Seizures / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology; D014613:Vaccines, Attenuated / Q000276:immunology / Q000592:standards; D017778:Vaccines, Combined / Q000276:immunology / Q000592:standards
chemical_list: D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined