title: Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression.
abstract: Sebum production and excretion is a primary function of the sebaceous glands, but abnormally increased sebum production is a major cause of acne vulgaris. To identify a new candidate that regulates sebum production, we investigated the possible inhibitory effects of apple polyphenols (APP) purified from unripe apples on primary cultured human sebocytes and in patients with acne vulgaris. Dexamethasone (Dex) increased lipid synthesis and expression of the sterol response element-binding protein 1 (SREBP 1) and its target enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), in the sebocytes. However, APP inhibited Dex-induced lipid production and expression of SREBP-1, ACC and FAS. APP also inhibited the increase in the expression and activation of glucocorticoid receptor in the sebocytes. Taken together, these results suggest that APP may be useful to regulate sebum production and may alleviate sebum-involved skin disease, such as acne vulgaris.
authors.affiliation: R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.
authors.forename: Kyung-Eun
authors.identifier: 0000-0001-8656-2263
authors.initials: KE
authors.lastname: Lee
authors.affiliation: R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.
authors.forename: Jong-Kyung
authors.initials: JK
authors.lastname: Youm
authors.affiliation: Department of Dermatology, Kyungpook National University School of Medicine, Daegu, South Korea.
authors.forename: Weon Ju
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.
authors.forename: Seunghyun
authors.initials: S
authors.lastname: Kang
authors.affiliation: R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.
authors.forename: Youn Joon
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology; D054890:Fatty Acid Synthase, Type I / Q000235:genetics / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000096:biosynthesis; D050155:Lipogenesis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D061251:Primary Cell Culture; D012627:Sebaceous Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics* / Q000378:metabolism*; D013634:Tannins / Q000494:pharmacology*
chemical_list: D005419:Flavonoids; D005938:Glucocorticoids; D008055:Lipids; D010936:Plant Extracts; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D013634:Tannins; C526219:apple polyphenol extract; D002726:Chlorogenic Acid; D003907:Dexamethasone; C518729:FASN protein, human; D054890:Fatty Acid Synthase, Type I; D000103:Acetyl-CoA Carboxylase
keywords: Polyphenol-rich apple extract; acne vulgaris; sebocytes; sebum; sterol response element-binding protein 1