title: Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data.
abstract: Rhinovirus (RV) is a common respiratory viral infection linked to worsening of chronic respiratory diseases including cystic fibrosis (CF) and asthma. RV was tested by RT-PCR in samples (n = 465) collected from the upper (nasal swab, oropharyngeal suction, and sputum) and lower (bronchoalveolar washings) respiratory tract of 110 children with CF. Air samples (n = 52) collected from the operating theatres and outpatient clinics were tested for RV. RV was found in 43% of children <5 years suffering an exacerbation, and 12% of older children (5-17 years). RV particles were detected in the air of clinic rooms. Detection of RV is important in better understanding viral infections in patients with CF.
authors.affiliation: Virology Research Laboratory, Prince of Wales Hospital, New South Wales, Australia.|Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, Australia.
authors.forename: Sacha
authors.identifier: 0000-0001-6037-9305
authors.initials: S
authors.lastname: Stelzer-Braid
authors.affiliation: Virology Research Laboratory, Prince of Wales Hospital, New South Wales, Australia.|Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, Australia.
authors.forename: Nancy
authors.initials: N
authors.lastname: Liu
authors.affiliation: Sydney Children's Hospital, New South Wales, Australia.|Faculty of Medicine, School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Doumit
authors.affiliation: Virology Research Laboratory, Prince of Wales Hospital, New South Wales, Australia.|Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, Australia.
authors.forename: Russell
authors.initials: R
authors.lastname: D'Cunha
authors.affiliation: Sydney Children's Hospital, New South Wales, Australia.|Faculty of Medicine, School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Belessis
authors.affiliation: Sydney Children's Hospital, New South Wales, Australia.|Faculty of Medicine, School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
authors.forename: Adam
authors.initials: A
authors.lastname: Jaffe
authors.affiliation: Virology Research Laboratory, Prince of Wales Hospital, New South Wales, Australia.|Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, Australia.
authors.forename: William D
authors.initials: WD
authors.lastname: Rawlinson
mesh_terms: D000293:Adolescent; D000391:Air Microbiology; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010850:Picornaviridae Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012137:Respiratory System / Q000821:virology*; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012229:Rhinovirus / Q000302:isolation & purification*
chemical_list: D012367:RNA, Viral
keywords: epidemiology; pathogenesis; respiratory tract; rhinovirus