title: Visualization of Posttraumatic Splenosis on Chemokine Receptor CXCR4-Targeted PET/CT.
abstract: The C-X-C motif chemokine receptor 4 (CXCR4) is expressed by a variety of inflammatory and malignant cells. We report the case of a 54-year-old woman with recurrent urinary tract infection who underwent a Ga-pentixafor PET/CT for detection of occult infectious foci. As a secondary finding, multiple CXCR4 abdominal lesions could be seen, consistent with the diagnosis of long-known posttraumatic splenosis. It is important to be aware that CXCR4-directed imaging may identify splenic tissue based on the presence of inflammatory cells and that both benign and malignant cells may show CXCR4 expression to avoid misinterpretation.
authors.affiliation: From the *Department of Nuclear Medicine, Hannover Medical School, Hannover; †Radiopharmaceutical Chemistry, Technical University Munich, Garching; and ‡Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Derlin
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Wester
authors.forename: Frank M
authors.initials: FM
authors.lastname: Bengel
authors.forename: Katja
authors.initials: K
authors.lastname: Hueper
mesh_terms: D056831:Coordination Complexes; D005260:Female; D006801:Humans; D008875:Middle Aged; D010456:Peptides, Cyclic; D000072078:Positron Emission Tomography Computed Tomography; D019718:Receptors, CXCR4 / Q000378:metabolism*; D012008:Recurrence; D017890:Splenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014552:Urinary Tract Infections / Q000150:complications
chemical_list: C000597686:68Ga-pentixafor; D056831:Coordination Complexes; D010456:Peptides, Cyclic; D019718:Receptors, CXCR4