title: The new sepsis definition: limitations and contribution to research and diagnosis of sepsis.
abstract: OBJECTIVE
  Based on recent clinical, epidemiological, and pathophysiological data, a third international consensus conference was carried out to define new criteria of sepsis in February 2016. This review presents the different items of this new definition, their limitations and their contribution to research and diagnosis of sepsis, in comparison with the previous definitions.
  
  
  RESULTS
  Incidence, management, and pathophysiological knowledge of sepsis have improved over the past 20 years. However, sepsis still evolves to a mortal outcome, in one case out of five, with no new recent or specific therapy showing its efficacy on the patient's prognosis. These findings have led to the development of new definition.
  
  
  CONCLUSIONS
  The new definition of sepsis incorporates relevant clinical and biological criteria such as SOFA score or serum lactate levels. It no longer takes into account the items of the systemic inflammatory response syndrome, which present a lack of specificity. It also simplifies the different stages of severity by deleting the term of 'severe sepsis' and by defining septic shock as a subset of sepsis. This definition, endorsed by only two international societies of intensive care, has some limitations and so merits prospective validation at different levels.
authors.affiliation: aDepartment of Anesthesiology and Critical Care, SMUR and Burn Unit, GH Saint-Louis-Lariboisière-Fernand Widal University Hospitals, Assistance Publique-Hôpitaux de Paris bInfection and Epidemiology Department, Human Histopathology and Animal Models Unit, Institut Pasteur cUniversity Paris Diderot, Sorbonne Paris Cité dU 942 INSERM, Paris, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Verdonk
authors.forename: Alice
authors.initials: A
authors.lastname: Blet
authors.forename: Alexandre
authors.initials: A
authors.lastname: Mebazaa
mesh_terms: D003245:Consensus Statements as Topic; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D063305:Organ Dysfunction Scores; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D012955:Societies, Medical
chemical_list: D019344:Lactic Acid