title: The Use of L-sIDOL Transgenic Mice as a Murine Model to Study Hypercholesterolemia and Atherosclerosis.
abstract: There are many advantages to the use of mice as a model to study the regulation of cholesterol metabolism. Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice. Herein, we describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis.
authors.affiliation: Lipid Metabolism and Cardiometabolic Disease Laboratory, Baker IDI Heart and Diabetes Institute, St Kilda Rd Central, 6492, Melbourne, VIC, 3004, Australia.
authors.forename: Eser J
authors.initials: EJ
authors.lastname: Zerenturk
authors.affiliation: Lipid Metabolism and Cardiometabolic Disease Laboratory, Baker IDI Heart and Diabetes Institute, St Kilda Rd Central, 6492, Melbourne, VIC, 3004, Australia. Anna.calkin@bakeridi.edu.au.|Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia. Anna.calkin@bakeridi.edu.au.
authors.forename: Anna C
authors.initials: AC
authors.lastname: Calkin
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D006937:Hypercholesterolemia / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D009928:Organ Specificity / Q000235:genetics; D011973:Receptors, LDL / Q000172:deficiency; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis / Q000235:genetics
chemical_list: D001057:Apolipoproteins E; D011973:Receptors, LDL; C542022:Mylip protein, mouse; D044767:Ubiquitin-Protein Ligases
keywords: Atherosclerosis; Hypercholesterolemia; IDOL; LDL cholesterol; LDLR; Liver; Mouse model; Transgenic