title: Papillomaviruses: a systematic review.
abstract: In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds. To overcome the problem, the vaccines that we have been developing involve recombinant DNA technology, aiming at prophylactic and therapeutic procedures. It is important to point out that these strategies can be used as models for innovative procedures against HPV, as this virus is the main causal agent of cervical cancer, the second most fatal cancer in women.
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.|Programa de Pós-graduação Interunidades em Biotecnologia, Instituto de Ciências Biomédicas (ICB), Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Rodrigo Pinheiro
authors.initials: RP
authors.lastname: Araldi
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Suely Muro Reis
authors.initials: SMR
authors.lastname: Assaf
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Rodrigo Franco de
authors.initials: RF
authors.lastname: Carvalho
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.|Programa de Aprimoramento Profissional (PAP), Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Márcio Augusto Caldas Rocha de
authors.initials: MACR
authors.lastname: Carvalho
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.|Programa de Pós-graduação Interunidades em Biotecnologia, Instituto de Ciências Biomédicas (ICB), Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Jacqueline Mazzuchelli de
authors.initials: JM
authors.lastname: Souza
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.|Programa de Pós-graduação Interunidades em Biotecnologia, Instituto de Ciências Biomédicas (ICB), Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Roberta Fiusa
authors.initials: RF
authors.lastname: Magnelli
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Diego Grando
authors.initials: DG
authors.lastname: Módolo
authors.affiliation: Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli Federico II, Napoli, Campania, Italy.
authors.forename: Franco Peppino
authors.initials: FP
authors.lastname: Roperto
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Rita de Cassia
authors.initials: RC
authors.lastname: Stocco
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Willy
authors.initials: W
authors.lastname: Beçak