title: rt-PA with Antithrombotic Therapies in a Case with Capsular Warning Syndrome.
abstract: We herein report a case of capsular warning syndrome (CWS) that was successfully treated with recombinant tissue plasminogen activator (rt-PA). A 70-year-old woman had repeated stereotyped transient ischemic attacks (TIAs) of right hemiparesis and dysarthria. After hospitalization, argatroban, aspirin, and cilostazol were started but were ineffective. Thirteen hours after the first episode of TIAs, severe symptoms occurred. Magnetic resonance imaging showed acute infarctions in the internal capsule to corona radiata, so we used rt-PA. Since then, the TIAs have not occurred, and the symptoms have considerably improved. This case suggests that rt-PA might be effective and safe for use in treating CWS.
authors.affiliation: Department of Neurology, Kyoto University Graduate School of Medicine, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fuseya
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kawamura
authors.forename: Eri
authors.initials: E
authors.lastname: Matsuda
authors.forename: Kozue
authors.initials: K
authors.lastname: Takada
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Watanabe
authors.forename: Junko
authors.initials: J
authors.lastname: Fujitake
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Nakaya
mesh_terms: D002544:Cerebral Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D038524:Diffusion Magnetic Resonance Imaging; D004401:Dysarthria / Q000209:etiology; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D020772:Internal Capsule / Q000000981:diagnostic imaging; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D018810:Magnetic Resonance Angiography; D008297:Male; D010291:Paresis / Q000209:etiology; D011994:Recombinant Proteins / Q000627:therapeutic use; D013577:Syndrome; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator