title: Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma.
abstract: Cardiac rhabdomyomas are common in tuberous sclerosis. We report a child who developed rhabdomyoma related arrhythmia refractory to antiarrhythmic drug therapy. Reversion of the atrial ectopic tachycardia was achieved with mammalian target of rapamycin pathway (mTOR) inhibitor sirolimus. As per our knowledge, this is the first time that sirolimus has been successfully used in this setting.
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Ninic
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.
authors.forename: Marija
authors.initials: M
authors.lastname: Kalaba
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.
authors.forename: Bosiljka
authors.initials: B
authors.lastname: Jovicic
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.|School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Vukomanovic
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.|School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Sergej
authors.initials: S
authors.lastname: Prijic
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Vucetic
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.|School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ruzica
authors.initials: R
authors.lastname: Kravljanac
authors.affiliation: Pediatric Clinic, Clinical Centre Kragujevac, Kragujevac, Serbia.|School of Medicine, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Vujic
authors.affiliation: Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.|School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Jovan
authors.initials: J
authors.lastname: Kosutic
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D012207:Rhabdomyoma / Q000150:complications* / Q000188:drug therapy*; D020123:Sirolimus / Q000627:therapeutic use*; D013612:Tachycardia, Ectopic Atrial / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus
keywords: arrhythmia; m-TOR inhibitor; rhabdomyoma; sirolimus