title: Marine Enzymes in Cancer: A New Paradigm.
abstract: Over the last decades, the vast chemical and biodiversity of marine environment has been identified as an important source of new anticancer drugs. The evolution of marine life is a result of competition among microorganisms for space and nutrients in the marine environment, which drives marine microorganisms to generate diverse enzyme systems with unique properties to adapt to harsh conditions of ocean. Therefore, marine-derived sources offer novel enzymes endowed with extraordinary properties. Recent advances in cancer therapy have facilitated enzyme therapy as a promising tool. But, the available information on the use of enzymes derived from marine sources as therapeutic agents for cancer therapy is scanty. The potential utility of marine enzymes in cancer therapy will be discussed in this chapter.
authors.affiliation: Institute of Chemical Technology, Mumbai, Maharashtra, India.
authors.forename: R H
authors.initials: RH
authors.lastname: Prabhu
authors.affiliation: Institute of Chemical Technology, Mumbai, Maharashtra, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Bhise
authors.affiliation: Institute of Chemical Technology, Mumbai, Maharashtra, India. Electronic address: vbp_muict@yahoo.co.in.
authors.forename: V B
authors.initials: VB
authors.lastname: Patravale
mesh_terms: D000110:Acetylcholinesterase / Q000627:therapeutic use; D000970:Antineoplastic Agents; D059001:Aquatic Organisms / Q000201:enzymology*; D001119:Arginase / Q000627:therapeutic use; D001215:Asparaginase / Q000627:therapeutic use; D045744:Cell Line, Tumor; D005972:Glutaminase / Q000627:therapeutic use; D006026:Glycoside Hydrolases / Q000627:therapeutic use; D006801:Humans; D006867:Hydrolases / Q000627:therapeutic use; D042845:Laccase / Q000627:therapeutic use; D009113:Muramidase / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D010447:Peptide Hydrolases / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D042845:Laccase; D006867:Hydrolases; D000110:Acetylcholinesterase; D006026:Glycoside Hydrolases; D009113:Muramidase; D010447:Peptide Hydrolases; D001215:Asparaginase; D005972:Glutaminase; D001119:Arginase; C019723:arginine deiminase
keywords: Antiangiogenesis; Anticancer; Apoptosis; Enzyme therapy; Marine enzymes; Nutrient depletion