title: [Allogeneic hematopoietic stem cell transplantation in Hungary].
abstract: OBJECTIVE
  The publication summarizes the 2548 stem cell transplantations performed in the period of 1993-2015 in Szent Laszló Hospital, Budapest and provides a detailed discussion of the 425 allogeneic transplantations during 2007-2013.
  
  
  METHODS
  The analysis explains the major steps of the evolution of allogeneic stem cell transplantation and compares the results of the unique Hungarian allogeneic center.
  
  
  RESULTS
  The significant shift in the transplantation indications from chronic myeloid leukemia to myelodysplastic syndromes and the rising age of the recipients are in line with world wide tendencies. The latter one is the consequence of the introduction and improvement of the concept of reduced intensity conditioning regimens, originally arising from the idea of Endre Kelemen. The most limiting factor, the donor availability seems to be resolved with the use of a new immunomodulating regimen, the application of posttransplantation cyclophosphamide, which allows the transplantation through HLA barriers with haploidentical family donors with comparable results to the HLA matched volunteer unrelated donors. The above mentioned tendencies result the wider use of allogeneic stem cell transplantation less dependent from recipient age, comorbidities and even donor availability.
  
  
  CONCLUSIONS
  The publication highlights the need of expanding the stem cell transplantation budget and the involvement of new centers in Hungary in allogeneic of stem cell transplantation. Orv. Hetil., 2017, 158(8), 291-297.
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Árpád
authors.initials: Á
authors.lastname: Bátai
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Péter
authors.initials: P
authors.lastname: Reményi
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Marienn
authors.initials: M
authors.lastname: Réti
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Anikó
authors.initials: A
authors.lastname: Barta
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: László
authors.initials: L
authors.lastname: Gopcsa
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Lilla
authors.initials: L
authors.lastname: Lengyel
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Éva
authors.initials: É
authors.lastname: Torbágyi
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Csukly
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Éva
authors.initials: É
authors.lastname: Karászi
authors.affiliation: Molekuláris Diagnosztikai Laboratórium, Országos Vérellátó Szolgálat Budapest.|Kórélettani Intézet, Semmelweis Egyetem Budapest.
authors.forename: Attila
authors.initials: A
authors.lastname: Tordai
authors.affiliation: Molekuláris Diagnosztikai Laboratórium, Országos Vérellátó Szolgálat Budapest.
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Andrikovics
authors.affiliation: Molekuláris Diagnosztikai Laboratórium, Országos Vérellátó Szolgálat Budapest.
authors.forename: Katalin
authors.initials: K
authors.lastname: Balassa
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Tasnády
authors.affiliation: III. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085; Budapest, Pf. 2, 1428.
authors.forename: Tamás
authors.initials: T
authors.lastname: Masszi
mesh_terms: D064591:Allografts; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data*; D006650:Histocompatibility Testing; D006801:Humans; D006814:Hungary; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate
keywords: allogeneic stem cell transplantation; allogén transzplantáció; hematology; hematológia