title: Synthesis and in vivo fungicidal activity of some new quinoline derivatives against rice blast.
abstract: BACKGROUND
  Quinoline derivatives possess excellent fungicidal activity against rice blast, but quinoline derivatives have not been thoroughly explored as fungicides. In the process of designing new fungicides, the 1,1,1,2,3,3,3-heptafluoropropan-2-yl group was introduced in order to find new structure quinoline derivatives.
  
  
  RESULTS
  Seventeen new quinoline derivatives containing 1,1,1,2,3,3,3-heptafluoropropan-2-yl moiety were designed and synthesised. In vivo fungicidal activities of these compounds were tested against rice blast. Some of the compounds provided effective control at 100 mg L-1, and a few compounds were effective at 10 mg L-1. Furthermore, a density functional theory study established the structure-activity relationships of the synthesised compounds.
  
  
  CONCLUSIONS
  Quinoline derivatives, especially benzyl (2,3,8-trimethyl-6-(perfluoropropan-2-yl)quinolin-4-yl) carbonate, which possess good control effective against rice blast and cucumber powdery mildew, may become new lead compounds for the development of fungicides with further structure modification. © 2017 Society of Chemical Industry.
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Xing-Hai
authors.initials: XH
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.|Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou, China.
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Fang
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xie
authors.affiliation: Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou, China.
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Zhang
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Shen
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Chen-Xia
authors.initials: CX
authors.lastname: Tan
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Weng
authors.affiliation: Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou, China.
authors.forename: Tian-Ming
authors.initials: TM
authors.lastname: Xu
authors.affiliation: Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou, China.
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Huang
mesh_terms: D060326:Chemistry Techniques, Synthetic; D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020082:Magnaporthe / Q000187:drug effects*; D008958:Models, Molecular; D008968:Molecular Conformation; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D005659:Fungicides, Industrial; D011804:Quinolines
keywords: SAR; fungicidal activity; quinoline; rice blast; synthesis