title: Data quality assurance and control in cognitive research: Lessons learned from the PREDICT-HD study.
abstract: We discuss the strategies employed in data quality control and quality assurance for the cognitive core of Neurobiological Predictors of Huntington's Disease (PREDICT-HD), a long-term observational study of over 1,000 participants with prodromal Huntington disease. In particular, we provide details regarding the training and continual evaluation of cognitive examiners, methods for error corrections, and strategies to minimize errors in the data. We present five important lessons learned to help other researchers avoid certain assumptions that could potentially lead to inaccuracies in their cognitive data.
authors.affiliation: Department of Neurology, Vanderbilt Medical Center, Nashville, TN, USA.|Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Holly James
authors.initials: HJ
authors.lastname: Westervelt
authors.affiliation: Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.|Department of Psychology, Pennsylvania State University, University Park, PA, USA.
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Bernier
authors.affiliation: Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.|Graduate School of Nursing, University of Massachusetts Medical School, Worcester, MA, USA.|Department of Neurology, Butler Hospital, Providence, RI, USA.
authors.forename: Melanie
authors.initials: M
authors.lastname: Faust
authors.affiliation: Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Gover
authors.affiliation: Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.|Advanced Biomedical Informatics Group, LLC, Coralville, IA, USA.
authors.forename: H Jeremy
authors.initials: HJ
authors.lastname: Bockholt
authors.affiliation: Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
authors.forename: Roland
authors.initials: R
authors.lastname: Zschiegner
authors.affiliation: Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.|Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Long
authors.affiliation: Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.|Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.|Department of Psychology, The University of Iowa, Iowa City, IA, USA.
authors.forename: Jane S
authors.initials: JS
authors.lastname: Paulsen
mesh_terms: D035843:Biomedical Research / Q000592:standards*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology; D000068598:Data Accuracy; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000175:diagnosis*; D008137:Longitudinal Studies; D009483:Neuropsychological Tests / Q000592:standards*; D062706:Prodromal Symptoms; D011379:Prognosis; D011786:Quality Control
keywords: cognitive assessment; quality assurance; quality control