title: Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma.
abstract: Hepatic sinusoidal obstruction syndrome (SOS), a serious complication that mainly occurs after hematopoietic-stem cell transplantation (HSCT), is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid. Recently, hepatic SOS was reported to occur after non-HSCT chemotherapies. This report describes a patient who experienced hepatic SOS after non-HSCT chemotherapy for non-Hodgkin lymphoma. A liver biopsy showed the slight dilatation of the hepatic sinusoid, which may be indicative of hepatic SOS. Hepatic SOS should be included in the differential diagnosis of patients with severe liver injury following the administration of chemotherapy regimens that are toxic to the vascular endothelial cells.
authors.affiliation: The Third Department of Internal Medicine, Toyama University Hospital, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Sakumura
authors.forename: Kazuto
authors.initials: K
authors.lastname: Tajiri
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Miwa
authors.forename: Kohei
authors.initials: K
authors.lastname: Nagata
authors.forename: Kengo
authors.initials: K
authors.lastname: Kawai
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Miyazono
authors.forename: Kotaro
authors.initials: K
authors.lastname: Arita
authors.forename: Akinori
authors.initials: A
authors.lastname: Wada
authors.forename: Jun
authors.initials: J
authors.lastname: Murakami
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed