title: Comparison of thyroid function tests and blood count in pregnant women with versus without gestational diabetes mellitus.
abstract: OBJECTIVE
  The aim of this study was to compare thyroid function and complete blood count parameters in pregnant women with versus without gestational diabetes mellitus (GDM).
  
  
  METHODS
  A total of 269 pregnant women patients with (n = 110, GDM group) or without (n = 159, non-GDM group) GDM were included in this study. Data on age, rate of cesarean section, birthweight of neonate, hemogram, and thyroid function tests were collected. Multivariate analysis was performed to determine factors predicting increased risk of GDM.
  
  
  RESULTS
  Rate of cesarean section (70.9 vs 57.2%, P = 0.022), median (max-min) age (33.0 [26.0] vs 26.0 [20.0] years, P < 0.001), platelet count (246.7 ± 68.3 vs 227.8 ± 64.2 ×103/μL, P = 0.021) and thyroid-stimulating hormone (1.3 [97.6] vs 1.0 [4.1] μIU/mL, P = 0.028) were significantly higher in the GDM than in the non-GDM group; whereas mean platelet volume (10.4 [5.3] vs 10.6 [5.6] fL, P = 0.031) and free triiodothyronine (FT3) (2.9 [3.6] vs 3.1 [3.0] pg/mL, P < 0.001) levels were significantly lower in the GDM than in the non-GDM group. Older age (odds ratio, 1.281; 95% confidence interval, 1.182-1.389, P < 0.001) and lower FT3 levels (odds ratio, 0.295; 95% confidence interval, 0.149-0.586, P < 0.001) were independently associated with increased risk of GDM.
  
  
  CONCLUSIONS
  Our findings revealed that lower FT3 levels and older age predict the likelihood of developing GDM in euthyroid pregnant women, with no influence of other thyroid hormones or blood counts on the risk of GDM.
authors.affiliation: Department of Endocrinology and Metabolism, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Suheyla
authors.initials: S
authors.lastname: Gorar
authors.affiliation: Department of Internal Medicine, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Gul Babacan
authors.initials: GB
authors.lastname: Abanonu
authors.affiliation: Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Uysal
authors.affiliation: Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Erol
authors.affiliation: Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Unal
authors.affiliation: Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Seyit
authors.initials: S
authors.lastname: Uyar
authors.affiliation: Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Ayhan Hilmi
authors.initials: AH
authors.lastname: Cekin
mesh_terms: D000328:Adult; D000367:Age Factors; D001772:Blood Cell Count; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D063847:Mean Platelet Volume / Q000706:statistics & numerical data*; D011247:Pregnancy; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D055815:Young Adult
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin
keywords: blood count; gestational diabetes; neonatal birthweight; thyroid hormones; thyroid status