title: [Acute-on-chronic liver failure: a diagnostic and therapeutic challenge for intensive care].
abstract: Acute-on-chronic liver failure (ACLF) is an emerging clinical syndrome in patients with underlying liver disease that is usually triggered by one or multiple insults and characterized by progressive hepatic and nonhepatic organ failure, a significant risk of infections, and high short-term mortality rates. Despite our incomplete understanding of the underlying pathophysiology, ACLF requires timely diagnostic and therapeutic measures aiming at the identification and elimination of causative factors as well as the prevention of complications to improve the prognosis of affected patients.
authors.affiliation: I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Hübener
authors.affiliation: III. Medizinische Klinik, Klinikum Augsburg, Augsburg, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Braun
authors.affiliation: Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland. v.fuhrmann@uke.de.
authors.forename: V
authors.initials: V
authors.lastname: Fuhrmann
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000175:diagnosis / Q000628:therapy; D003422:Critical Care; D006801:Humans; D011379:Prognosis
keywords: Cirrhosis; Infection; Liver failure; Organ failure; Transplantation