title: Elevated Pre-Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection.
abstract: Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39+CD8+ T cell frequency was independently associated with mortality within 6 months of ART initiation.
authors.affiliation: Department of Medicine, Division of Infectious Diseases and.|Botswana-UPenn Partnership, Gaborone.
authors.forename: Shruthi
authors.initials: S
authors.lastname: Ravimohan
authors.affiliation: Botswana-UPenn Partnership, Gaborone.
authors.forename: Neo
authors.initials: N
authors.lastname: Tamuhla
authors.affiliation: Botswana-UPenn Partnership, Gaborone.
authors.forename: Kebatshabile
authors.initials: K
authors.lastname: Nfanyana
authors.affiliation: Department of Medicine, Division of Infectious Diseases and.
authors.forename: Houping
authors.initials: H
authors.lastname: Ni
authors.affiliation: Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.|Botswana-UPenn Partnership, Gaborone.|Children's Hospital of Philadelphia, Pennsylvania, and.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Steenhoff
authors.affiliation: Department of Medicine, Division of Infectious Diseases and.|Botswana-UPenn Partnership, Gaborone.|Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
authors.forename: Robert
authors.initials: R
authors.lastname: Gross
authors.affiliation: Department of Medicine, Division of Infectious Diseases and.|Botswana-UPenn Partnership, Gaborone.
authors.forename: Drew
authors.initials: D
authors.lastname: Weissman
authors.affiliation: Department of Medicine, Division of Infectious Diseases and.|Botswana-UPenn Partnership, Gaborone.|Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Bisson
mesh_terms: D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D001081:Apyrase / Q000235:genetics / Q000276:immunology*; D015415:Biomarkers; D001902:Botswana / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015331:Cohort Studies; D060085:Coinfection / Q000401:mortality*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014376:Tuberculosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents; D015703:Antigens, CD; D015415:Biomarkers; D001081:Apyrase; C067869:CD39 antigen
keywords: CD39; CD8+ T cells.; HIV; early mortality; tuberculosis