title: Pathological complete response in a patient affected by multiple synchronous, breast and lung primary malignancies: a case report and review of the literature.
abstract: A pathological complete response in a patient affected by multiple synchronous, breast and lung primary malignancies is reported. A 63-year-old woman presented with an invasive ductal carcinoma of the breast and a lung adenocarcinoma. After multidisciplinary discussion, the patient underwent pulmonary left lower lobectomy followed by radio-chemotherapy with cisplatin and vinorelbine and started hormone therapy with letrozole. Ten months later, a left mastectomy with axillary lymph nodes dissection was performed. Histologically, a pathological complete response (pCR) was documented. With a review of the Literature, we discuss the issue of multiple primary malignancies, with its diagnostic and therapeutic implications. In cases of multiple synchronous malignancies it has been highlighted the importance of the choice of the best therapeutic approach for both the malignancies, reducing collateral individual effects.
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Nottegar
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Luchini
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cingarlini
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Beccari
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Grego
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Gilioli
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Manfrin
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bonetti
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy; D000077192:Adenocarcinoma of Lung; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D016896:Treatment Outcome
keywords: Breast cancer; Multiple primary malignancies; Pathological complete response; Pulmonary adenocarcinoma