title: Mouse genomic screen reveals novel host regulator of metastasis.
abstract: Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
authors.forename: Toni
authors.initials: T
authors.lastname: Celià-Terrassa
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA. ykang@princeton.edu.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Kang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D023281:Genomics / Q000379:methods; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*