title: Encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with Spindle Cell Metaplasia: Case report and review of literature.
abstract: Spindle cell lesions of the thyroid are rare overall, and span a wide clinical spectrum that ranges from spindle cell metaplasia (SCM1) to anaplastic carcinoma. Their differentiation is only seldom straightforward, and usually requires the integration of the clinical, histological and immunohistochemical data. Only a handful of publications have described cases of SCM in the thyroid and we add to that literature by reporting a unique case of encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with SCM. In addition, we review the literature on the relationship between SCM and different thyroid lesions, summarizing the morphological and immunohistochemical features that aid in its differentiation from more aggressive spindle cell proliferations.
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Suite 130 CSN, Chicago, IL, 60612, USA. Electronic address: mharoon@uic.edu.
authors.forename: Mohamed Rizwan
authors.initials: MR
authors.lastname: Haroon Al Rasheed
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Suite 130 CSN, Chicago, IL, 60612, USA. Electronic address: amacosta@uic.edu.
authors.forename: Andres
authors.initials: A
authors.lastname: Acosta
authors.affiliation: Department of Pathology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, USA. Electronic address: gtarjan@cookcountyhhs.org.
authors.forename: Gabor
authors.initials: G
authors.lastname: Tarjan
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: EFVPTC; Endocrine; Follicular neoplasm; HBME-1; NIFTP; Spindled lesion