title: NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis.
abstract: Anxiety is controlled by multiple neuronal circuits that share robust and reciprocal connections with the bed nucleus of the stria terminalis (BNST), a key structure controlling negative emotional states. However, it remains unknown how the BNST integrates diverse inputs to modulate anxiety. In this study, we evaluated the contribution of infralimbic cortex (ILCx) and ventral subiculum/CA1 (vSUB/CA1) inputs in regulating BNST activity at the single-cell level. Using trans-synaptic tracing from single-electroporated neurons and in vivo recordings, we show that vSUB/CA1 stimulation promotes opposite forms of in vivo plasticity at the single-cell level in the anteromedial part of the BNST (amBNST). We find that an NMDA-receptor-dependent homosynaptic long-term potentiation is instrumental for anxiolysis. These findings suggest that the vSUB/CA1-driven LTP in the amBNST is involved in eliciting an appropriate response to anxiogenic context and dysfunction of this compensatory mechanism may underlie pathologic anxiety states.
authors.affiliation: Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33076 Bordeaux, France.|Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33076 Bordeaux, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Glangetas
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Léma
authors.initials: L
authors.lastname: Massi
authors.affiliation: Centre National de la Recherche Scientifique, Neurodegeneratives Diseases Institute, UMR 5293, F-33076 Bordeaux, France.
authors.forename: Giulia R
authors.initials: GR
authors.lastname: Fois
authors.affiliation: Université de la Méditerranée UMR S901, F-13009 Aix-Marseille 2, France.|INMED, F-13009 Marseille, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Jalabert
authors.affiliation: Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33076 Bordeaux, France.|Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33076 Bordeaux, France.|Centre National de la Recherche Scientifique, Neurodegeneratives Diseases Institute, UMR 5293, F-33076 Bordeaux, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Girard
authors.affiliation: 'G. Minardi' Cognitive Neuroscience Laboratory, Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Diana
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yonehara
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Botond
authors.initials: B
authors.lastname: Roska
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Chun
authors.initials: C
authors.lastname: Xu
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lüthi
authors.affiliation: Université de Bordeaux, Institut de Neurosciences Cognitives et Intégrative d'Aquitaine, BP31, F-33076 Bordeaux, France.|Centre National de la Recherche Scientifique, UMR 5287-Institut de Neurosciences Cognitives et Intégrative d'Aquitaine, F-33076 Bordeaux, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Caille
authors.affiliation: Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33076 Bordeaux, France.|Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33076 Bordeaux, France.|Centre National de la Recherche Scientifique, Neurodegeneratives Diseases Institute, UMR 5293, F-33076 Bordeaux, France.
authors.forename: François
authors.initials: F
authors.lastname: Georges
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012686:Septal Nuclei / Q000166:cytology / Q000378:metabolism / Q000502:physiology*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate