title: A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition.
abstract: BACKGROUND
  Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently.
  
  
  METHODS
  A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations ofTP53or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331.
  
  
  CONCLUSIONS
  This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Mathias
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Ortiz
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: H
authors.initials: H
authors.lastname: Magnan
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Ambati
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: E K
authors.initials: EK
authors.lastname: Slotkin
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Chou
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: M F
authors.initials: MF
authors.lastname: Walsh
authors.affiliation: Department of Medicine, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: K
authors.initials: K
authors.lastname: Offit
authors.affiliation: Department of Leukemia, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: C
authors.initials: C
authors.lastname: Moskowitz
authors.affiliation: Department of Pediatrics, New York, NY USA.|Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: A
authors.initials: A
authors.lastname: Kentsis
authors.affiliation: Department of Pediatrics, New York, NY USA.|Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Wexler
keywords: Case report; Diffuse large B cell lymphoma; Molecular analysis; Rhabdomyosarcoma