title: Langerhans Cells: the 'Yin and Yang' of HIV Restriction and Transmission.
abstract: Langerhans cells are specialized sentinels present in the epidermis expressing Langerin, a specific C-type lectin receptor involved in HIV capture and destruction. Recently, the specific mechanism leading to this HIV restriction was discovered. Nevertheless, Langerhans cells can be infected and the way HIV escapes this restriction needs to be unraveled.
authors.affiliation: INSERM U1109, FMTS, University of Strasbourg, 3 rue Koeberlé, Strasbourg 67000, France.
authors.forename: Luzia
authors.initials: L
authors.lastname: Mayr
authors.affiliation: Beijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Su
authors.affiliation: INSERM U1109, FMTS, University of Strasbourg, 3 rue Koeberlé, Strasbourg 67000, France. Electronic address: c.moog@unistra.fr.
authors.forename: Christiane
authors.initials: C
authors.lastname: Moog
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology*; D037181:Lectins, C-Type / Q000378:metabolism; D037241:Mannose-Binding Lectins / Q000378:metabolism; D009092:Mucous Membrane / Q000276:immunology* / Q000821:virology
chemical_list: D015703:Antigens, CD; C121916:CD207 protein, human; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins