title: Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy.
abstract: Type 2 diabetic mellitus (T2DM) is a disease with high prevalence and a major cause for death worldwide. Diabetic retinopathy (DR) is one of the major manifestation of diabetes. Aldehyde dehydrogenease 2 (ALDH2) detoxifies aldehyde produced during ethanol metabolism and oxidative stress. It has been found that the polymorphism in ALDH2 rs671 is probably associated with the risk of T2DM and DR. However, a lot of inconsistency and controversy still exists. In order to get a more precise and comprehensive estimation for the association between ALDH2 polymorphism with the risk of T2DM and DR, we conducted the present meta-analysis. A comprehensive literature search was conducted using databases, such as Pubmed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, and Chinese Biomedical Literature Database, for all related studies. The included studies met the inclusion criteria, such as being case-control studies about the association of ALDH2 polymorphism and T2DM or DR susceptibility, with sufficient data for the present analysis. Eight studies with 2374 cases and 6694 controls were involved in the present meta-analysis. The results indicated a significant lower risk of T2DM for *1/*1 genotype in homozygous models (*1/*1 vs. *2/*2, OR = 0.31, 95% CI = 0.11-0.89, p = 0.03) and in the dominant model (*1/*1 vs. *2/*2 + *1/*2, OR = 0.61, 95% CI = 0.37-1.00, p = 0.05). Subgroup analysis by ethnicity found a significant lower risk of T2DM in Chinese in all genotype models. No significant relation was found between ALDH2 rs671 and DR. In conclusion, the current meta-analysis indicated that ALDH2 rs671 was significantly related with T2DM. The ALDH2 rs671 might be able to be used as a predictor for the risk of T2DM. However, due to the existence of heterogeneity and publication bias in the involved studies, our results should be interpreted with caution.
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. liguangyi1977@163.com.
authors.forename: Guang-Yi
authors.initials: GY
authors.lastname: Li
authors.affiliation: Department of Medical Laboratory, Changsha Medical University, Changsha 410219, China. lzb3039@126.com.
authors.forename: Zi-Bo
authors.initials: ZB
authors.lastname: Li
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. li-evans@hotmail.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. ddongliping@163.com.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Dong
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. tlcool318@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. xiang.ju@foxmail.com.
authors.forename: Ju
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. ljming0901@sina.com.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Li
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. mhbao78@163.com.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Bao
mesh_terms: D000071396:Aldehyde Dehydrogenase, Mitochondrial / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: C096127:ALDH2 protein, human; D000071396:Aldehyde Dehydrogenase, Mitochondrial
keywords: ALDH2 rs671; diabetic retinopathy; meta-analysis; polymorphism; type 2 diabetic mellitus