title: The synthesis of weak acidic type hybrid monolith via thiol-ene click chemistry and its application in hydrophilic interaction chromatography.
abstract: In this work, a porous structure and good permeability monolithic column was polymerized in UV transparent fused-silica capillaries via photo-initiated thiol-ene click polymerization of 2,4,6,8-tetravinyl-2,4,6,8-tetramethylcyclotetrasiloxane (TMTVS), pentaerythritol tetra(3-mercaptopropionate)(PETMP), itaconic acid, respectively, in the presence of porogenic solvents (tetrahydrofuranand methanol) and an initiator (2,2-dimethoxy-2-phenylacetophenone) (DMPA) within 30 min. The physical properties of this monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurements. For an overall evaluation of the monolith in chromatographic application, separations of polycyclic aromatic hydrocarbons (PAHs), phenols, amides and bases were carried out. The column efficiency of this monolith could be as high as 112 560 N/m. It also possesses a potential application in fabrication of monoliths with high efficiency for c-LC. In addition, the resulting monolithic column demonstrated the potential use in analysis of environment waters.
authors.affiliation: State Key Laboratory of Chemo/Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, P. R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Chemo/Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, P. R. China.
authors.forename: Shengquan
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Chemo/Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, P. R. China.
authors.forename: Menglin
authors.initials: M
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemo/Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, P. R. China.
authors.forename: Shouzhuo
authors.initials: S
authors.lastname: Yao
authors.affiliation: Key Laboratory of Phytochemical R&D of Hunan Province, Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha, P. R. China.
authors.forename: Yingzhuang
authors.initials: Y
authors.lastname: Chen
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D000097:Acetonitriles; D000577:Amides / Q000032:analysis / Q000302:isolation & purification; D002853:Chromatography, Liquid / Q000379:methods*; D057930:Click Chemistry / Q000379:methods*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D010636:Phenols / Q000032:analysis / Q000302:isolation & purification; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000302:isolation & purification; D011409:Propylene Glycols / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry*; D013386:Succinates / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D000577:Amides; D006571:Heterocyclic Compounds; D010636:Phenols; D011084:Polycyclic Aromatic Hydrocarbons; D011409:Propylene Glycols; D012833:Siloxanes; D013386:Succinates; D013438:Sulfhydryl Compounds; C501435:pentaerythritol tetra(3-mercaptopropionate); C110979:tetravinyl-tetramethylcyclo-tetrasiloxane; D015097:3-Mercaptopropionic Acid; C005229:itaconic acid; C032159:acetonitrile
keywords: Hydrophilic interaction; Monolithic column; Thiol-ene click polymerization