title: Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes.
abstract: Chloride is the most abundant permeable anion in the cell, and numerous studies in the last two decades highlight the great importance and broad physiological role of chloride currents mediated anion transport. They participate in a multiplicity of key processes, as for instance, the regulation of electrical excitability, apoptosis, cell cycle, epithelial secretion and neuronal excitability. In addition, dysfunction of Cl-channels is involved in a variety of human diseases such as epilepsy, osteoporosis and different cancer types. Historically, chloride channels have been of less interest than the cation channels. In fact, there seems to be practically no quantitative studies of the dynamics of chloride currents. Here, for the first time, we have quantitatively studied experimental calcium-activated chloride fluxes belonging to Xenopus laevis oocytes, and the main results show that the experimental Cl-currents present an informational structure characterized by highly organized data sequences, long-term memory properties and inherent "crossover" dynamics in which persistent correlations arise at short time intervals, while anti-persistent behaviors become dominant in long time intervals. Our work sheds some light on the understanding of the informational properties of ion currents, a key element to elucidate the physiological functional coupling with the integrative dynamics of metabolic processes.
authors.affiliation: Department of Nutrition, CEBAS-CSIC Institute, Espinardo University Campus, Murcia, Spain.|Department of Mathematics, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: Ildefonso
authors.initials: I
authors.lastname: M De la Fuente
authors.affiliation: Department of Mathematics, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: Iker
authors.initials: I
authors.lastname: Malaina
authors.affiliation: Department of Neurosciences, Faculty of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pérez-Samartín
authors.affiliation: Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Boyano
authors.affiliation: Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: Gorka
authors.initials: G
authors.lastname: Pérez-Yarza
authors.affiliation: Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Bringas
authors.affiliation: Biophysics Unit, CSIC, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Villarroel
authors.affiliation: Department of Biochemistry and Pharmacology, Institute of Parasitology and Biomedicine "López-Neyra", CSIC, Granada, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Fedetz
authors.affiliation: Laboratory of Cellular Neurophysiology, Neurobiology Institute, UNAM, Querétaro, México.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Arellano
authors.affiliation: Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain.|BioCruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain.|IKERBASQUE: The Basque Foundation for Science, Bilbao, Spain.
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Cortes
authors.affiliation: Department of Mathematics, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez
mesh_terms: D000465:Algorithms; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D018118:Chloride Channels / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D008564:Membrane Potentials; D008954:Models, Biological; D009865:Oocytes / Q000378:metabolism*; D014982:Xenopus laevis / Q000378:metabolism*
chemical_list: D018118:Chloride Channels; D002712:Chlorides; D002118:Calcium