title: The Effect of Treatment of Anemia with Blood Transfusion on Delirium: A Systematic Review.
abstract: OBJECTIVE
  Treating the precipitating factors of delirium is the mainstay of the prevention and treatment of delirium. We aim to investigate the role of anemia and blood transfusion within the multicomponent prevention and treatment strategy of delirium.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  We included cohort studies or Randomized Controlled Trials (RCTs) that considered blood transfusion as treatment for delirium or risk factor, and had delirium as outcome.
  
  
  METHODS
  Hospitalized patients above 55 years old.
  
  
  METHODS
  We searched MEDLINE from 1946 through November 2014. Quality assessment and data extraction were performed systematically.
  
  
  RESULTS
  We included 23 studies (n = 29,471). The majority of the studies (n = 22) had a limited quality and for one study quality was uncertain. Two studies evaluated the association between transfusion strategy and postoperative delirium and found no association. Twenty-one studies investigated blood transfusion as a risk factor for delirium. In four of the 21 studies it could be assumed that delirium occurred after transfusion. One of these studies stated that transfusion was a significant risk factor for subsequent delirium (odds ratio (OR) = 3.68, 95% confidence interval (CI) = 1.32-10.94). The other three studies found no association between transfusion and delirium. In the remaining 17 studies, it was not clear whether delirium occurred before or after transfusion, so no conclusion could be drawn on the role of transfusion in delirium development.
  
  
  CONCLUSIONS
  The majority of the included studies was not suited to answer the research question properly as the time course of the beginning of delirium as to transfusion was lacking. Our review shows that there is no good quality evidence available for blood transfusion to be a risk factor for delirium or to be a preventive or treatment option.
authors.affiliation: Geriatrics Section, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Vera
authors.initials: V
authors.lastname: van der Zanden
authors.affiliation: Geriatrics Section, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Beishuizen
authors.affiliation: Geriatrics Section, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Lieke M
authors.initials: LM
authors.lastname: Swart
authors.affiliation: Geriatrics Section, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.|Department of Internal Medicine, University Center of Geriatric Medicine, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Sophia E
authors.initials: SE
authors.lastname: de Rooij
authors.affiliation: Department of Internal Medicine, University Center of Geriatric Medicine, University Medical Center Groningen, Groningen, The Netherlands.|Department of Geriatrics, Gelre Hospitals, Apeldoorn, The Netherlands.
authors.forename: Barbara C
authors.initials: BC
authors.lastname: van Munster
mesh_terms: D000368:Aged; D000740:Anemia / Q000150:complications* / Q000628:therapy*; D001803:Blood Transfusion; D003693:Delirium / Q000209:etiology* / Q000517:prevention & control*; D006760:Hospitalization; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors
keywords: anemia; blood transfusion; delirium; elderly; geriatric