title: Intraocular Ependymoma With Blood-Filled Spaces: Neoplasm or a Reactive Process With Ependymal Differentiation-A Dilemma.
abstract: Intraocular glial lesions are rare and include retinal gliosis, hamartomas, and astrocytomas and rarely ependymomas. Ependymomas are slow-growing glial tumors preferentially arising in the central nervous system (CNS), occasionally presenting at sites outside the CNS, with only 2 cases of primary retinal ependymoma reported till date. We report herein the third such case of a 20-year-old male who presented with a painful blind eye. The enucleated specimen showed presence of a glial tumor with cells arranged in sheets as well as few true rosettes and pseudo-rosettes and an immunohistochemical profile similar to a classical ependymoma at usual sites in the CNS. Additionally, the presence of blood-filled spaces and few proliferating blood vessels made it a diagnostic challenge. All retinal glial lesions are positive for GFAP and S100. Therefore, immunostaining for EMA as well as the MIB-1-labeling index maybe vital in differentiating ependymomas from other intraocular glial lesions.
authors.affiliation: 1 Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Dewan
authors.affiliation: 1 Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors.forename: Ravindra Kumar
authors.initials: RK
authors.lastname: Saran
authors.affiliation: 2 Maulana Azad Medical College, New Delhi, India.
authors.forename: Smriti Nagpal
authors.initials: SN
authors.lastname: Gupta
authors.affiliation: 2 Maulana Azad Medical College, New Delhi, India.
authors.forename: Deepanjali
authors.initials: D
authors.lastname: Arya
authors.affiliation: 2 Maulana Azad Medical College, New Delhi, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Goel
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D004806:Ependymoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: EMA; glial; gliosis; intraocular ependymoma; vasoproliferative tumor of retina