title: Comparison of genetic characteristics in the evolution of Norovirus GII.4 and GII.17.
abstract: The genetic characteristics of Norovirus GII.17 were evaluated. Phylogenetic analysis and comparisons of amino acid (Aa) substitutions and nonsynonymous (NS) substitutions/site/year were performed. The complete VP1 sequence of Tokyo/27-3/1976 clustered independently with GII.P17_GII.17 strains. Aa substitutions were mainly accumulated in the P2 domain. NS substitutions/site/year for Tokyo/27-3/1976 compared to Kawasaki323/2014 and Kawasaki308/2015 were 0.57 × 10-3and 0.78 × 10-3, respectively; for GII.4 Sydney/NSW0514/2012 compared to CHDC2094/1974 and CHDC5191/1974 were 0.93 × 10-3and 1.06 × 10-3, respectively. These findings imply that evolutionary diversity in the VP1 of GII.17 might be strictly constrained in contrast to that of GII.4.
authors.affiliation: Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
authors.forename: Kohji
authors.identifier: 0000-0003-0521-4940
authors.initials: K
authors.lastname: Mori
authors.affiliation: Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Motomura
authors.affiliation: Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Somura
authors.affiliation: Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Kimoto
authors.affiliation: Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Akiba
authors.affiliation: Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sadamasu
mesh_terms: D019943:Amino Acid Substitution; D019143:Evolution, Molecular; D005838:Genotype; D006801:Humans; D029322:Norovirus / Q000145:classification* / Q000235:genetics*; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins
keywords: genetic variability; mutation; recombination