title: Clinical outcome of periodontal regenerative therapy using collagen membrane and deproteinized bovine bone mineral: a 2.5-year follow-up study.
abstract: BACKGROUND
  This study aimed to evaluate, longitudinally, the outcome of periodontal regenerative therapy using a deproteinized bovine bone mineral (DBBM) in combination with a collagen barrier (CB) for the treatment of intrabony defects.
  
  
  RESULTS
  Patients with chronic periodontitis who have completed initial periodontal therapy participated in this study. They had at least one 2- or 3-wall intrabony periodontal defect of ≥3 mm in depth. During surgery, defects were filled with DBBM and covered with CB. Ten patients completed 2.5-year reevaluation. At baseline, mean clinical attachment level (CAL) of the treated site was 8.0 mm and mean probing depth (PD) was 7.5 mm. Mean depth of intrabony component was 4.6 mm. Mean gains in CAL at 6 months and 2.5 years were 2.8 ± 1.0 and 1.4 ± 1.5 mm, respectively, both showing a significant improvement from baseline. CAL gains at 1 and 2.5 years were significantly reduced from that at 6 months. A significant improvement in PD was also noted: mean reductions in PD at 6 months and 2.5 years were 4.0 ± 0.8 and 3.2 ± 0.8 mm, respectively.
  
  
  CONCLUSIONS
  The combination therapy using DBBM and CB yielded statistically significant effects such as CAL gain and PD reduction, up to 2.5 years in the treatment of intrabony defects. However, the trend for decrease in CAL gain over time calls for the need for careful maintenance care.
authors.affiliation: Department of Periodontology, Tokyo Dental College, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Irokawa
authors.affiliation: Department of Periodontology, Tokyo Dental College, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Periodontology, Tokyo Dental College, Tokyo, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Noda
authors.affiliation: Private Practice, Goto Dental Clinic, Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Goto
authors.affiliation: Department of Periodontology, Tokyo Dental College, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Egawa
authors.affiliation: Department of Periodontology, Tokyo Dental College, Tokyo, Japan.
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Tomita
authors.affiliation: Department of Endodontics and Clinical Cariology, Tokyo Dental College, Tokyo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugito
authors.affiliation: Department of Periodontology, Tokyo Dental College, Tokyo, Japan.|Private Practice, Nikaido Dental Clinic, Tokyo, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nikaido
authors.affiliation: Department of Periodontology, Tokyo Dental College, Tokyo, Japan. atsaito@tdc.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals; D017063:Outcome Assessment, Health Care; D010518:Periodontitis / Q000601:surgery*
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen
keywords: Biomaterial; Bone grafting; Guided tissue regeneration; Periodontitis