title: Dopamine release in the nucleus accumbens is altered following traumatic brain injury.
abstract: Mild-to-severe traumatic brain injury (TBI) is frequently associated with prolonged dysfunction of reward circuitry, including motivation and salience, which suggests alterations of dopamine (DA) processing within the core and shell of the nucleus accumbens (NAC). Using fast-scan cyclic voltammetry in a rodent model of traumatic brain injury, we found that stimulus-evoked DA release is distinct in the core and shell of the NAC, with the shell being less responsive to tonic stimulation and more sensitive to the number of pulses when phasic stimulation is applied. Exposure to TBI was associated with major changes in both release and reuptake of DA in both the core and shell of NAC, with greater changes seen in the core. These alterations evolved over time, becoming most severe 1-2weeks after injury with subsequent recovery, and the extent and progression of these abnormalities was correlated with severity of injury. Taken together, these data support behavior and anatomical studies suggesting the NAC core and striatum may subserve parallel functions, whereas the shell is distinct. These data offer a unique window on how different neurological systems respond to TBI and may help explain affective and cognitive changes that are seen.
authors.affiliation: Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC. Electronic address: chenyh178@gmail.com.
authors.forename: Yuan-Hao
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, ROC.
authors.forename: Eagle Yi-Kung
authors.initials: EY
authors.lastname: Huang
authors.affiliation: Graduate Institute of Computer and Communication Engineering, National Taipei University of Technology, Taipei, Taiwan, ROC.
authors.forename: Tung-Tai
authors.initials: TT
authors.lastname: Kuo
authors.affiliation: Department of Neurosurgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Graduate Program on Neuroregeneration, Taipei Medical University, Taipei, Taiwan, ROC.
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Hoffer
authors.affiliation: Department of Neurosurgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Miller
authors.affiliation: School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Chou
authors.affiliation: Graduate Program on Neuroregeneration, Taipei Medical University, Taipei, Taiwan, ROC.
authors.forename: Yung-Hsiao
authors.initials: YH
authors.lastname: Chiang
mesh_terms: D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004298:Dopamine
keywords: dopamine; fast-scan cyclic voltammetry; nucleus accumbens; traumatic brain injury