title: Determinants of mortality in elderly patients with tuberculosis: a population-based follow-up study.
abstract: Elderly individuals with tuberculosis (TB) are more likely to have a non-specific clinical presentation of TB and high mortality. However, factors associated with mortality in elderly TB patients have not been extensively studied. This retrospective cohort study aimed to identify factors associated with death among elderly Taiwanese with TB. All elderly patients with TB from 2006 to 2014 in Taipei, Taiwan, were included in a study. Multiple logistic regression was used to identify the factors associated with death in elderly TB patients. The mean age of the 5011 patients was 79·7 years; 74·1% were men; 32·7% had mortality during the study follow-up period. After controlling for potential confounders, age ⩾75 years (reference: 65-74 years), male sex, end-stage renal disease (ESRD), malignancy, acid-fast bacilli-smear positivity, TB-culture positivity, pleural effusion on chest radiograph and notification by an ordinary ward or intensive care unit were associated with a higher risk of all-cause death; while high school, and university or higher education, cavity on chest radiograph and directly observed therapy were associated with a lower risk of all-cause death. This study found that the proportion of death among elderly patients with TB in Taipei, Taiwan, was high. To improve TB treatment outcomes, future control programmes should particularly target individuals with comorbidities (e.g. ESRD and malignancy) and those with a lower socio-economic status (e.g. not educated).
authors.affiliation: Section of Infectious Diseases,Taipei City Hospital, Taipei City Government,Taipei,Taiwan.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Yen
authors.affiliation: School of Medicine, National Yang-Ming University,Taipei,Taiwan.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Feng
authors.affiliation: School of Medicine, National Yang-Ming University,Taipei,Taiwan.
authors.forename: S-W
authors.initials: SW
authors.lastname: Pan
authors.affiliation: Center for Prevention and Treatment of Occupational Injury and Diseases, Taipei veterans General Hospital,Taipei,Taiwan.
authors.forename: P-H
authors.initials: PH
authors.lastname: Chuang
authors.affiliation: Department of Critical Care Medicine,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: V Y-F
authors.initials: VY
authors.lastname: Su
authors.affiliation: School of Medicine, National Yang-Ming University,Taipei,Taiwan.
authors.forename: W-J
authors.initials: WJ
authors.lastname: Su
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D013624:Taiwan / Q000453:epidemiology; D014376:Tuberculosis / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality*
keywords: Elderly; Taiwan; mortality; tuberculosis