title: Neurogenic ppendicopathy. A report of 8 cases.
abstract: BACKGROUND
  Neurogenic appendicopathy is not a very well-known disease.
  
  
  OBJECTIVE
  To analyze the experience in the management of neurogenic appendicopathy in a tertiary hospital, assessing its clinical presentation, histological staging, the treatment carried out and its clinical evolution.
  
  
  METHODS
  The study population included patients with histopathological criteria for neurogenic appendicopathy who did not present with MEN 2B syndrome, neurofibromatosis type I or Cowden syndrome. An analysis was carried out of tissue samples taken from a simple appendectomy after a diagnosis of neurogenic appendicopathy between 2000 and 2013, inclusive. The histopathological criteria were neurogenic hyperplasia with S-100 protein positivity and neuron-specific enolase in the immunohistochemical analysis.
  
  
  RESULTS
  Of the 4,969 samples from the appendectomies analyzed, 0.16% (n = 8) met histopathological criteria of neurogenic appendicopathy. The age at presentation was 27.8 ± 12 years. Four patients were male and four were female. All patients started with abdominal pain in the right iliac fossa (RIF), and were operated on due to a diagnosis of acute appendix, with a simple appendectomy being performed. In four cases, another associated disease accounted for the pain in the RIF. With regard to histopathological type, submucosal neurogenic hyperplasia was present in five patients and fibrous obliteration in three patients. No statistically significant differences were found between the histological types. After surgery, during a mean follow up of 73.2 ± 28 months (15-105), all the patients remained asymptomatic.
  
  
  CONCLUSIONS
  Neurogenic appendicopathy is an uncommon entity that can evolve as abdominal pain which is similar to acute appendix. Simple appendectomy is curative.
authors.affiliation: Cirugía General y del Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, España.
authors.forename: José
authors.initials: J
authors.lastname: Ruiz
authors.affiliation: Cirugía, Hospital Universitario Virgen de la Arrixaca, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ríos
authors.affiliation: Servicio de Anatomía Patológica, Hospital Clínico Universitario Virgen de la Arrixaca.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Oviedo
authors.affiliation: Cirugía , Hospital Clínico Universitario Virgen Arrixaca, España.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Rodríguez
authors.affiliation: Cirugía General y del Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, España.
authors.forename: Pascual
authors.initials: P
authors.lastname: Parrilla
mesh_terms: D000293:Adolescent; D000328:Adult; D001062:Appendectomy; D001064:Appendicitis / Q000175:diagnosis; D001065:Appendix / Q000473:pathology* / Q000601:surgery; D002429:Cecal Diseases / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000453:epidemiology / Q000473:pathology; D008297:Male; D055496:Neurogenic Bowel / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D055815:Young Adult