title: Efficacy and safety of super selective bronchial artery coil embolisation for haemoptysis: a single-centre retrospective observational study.
abstract: Evidence on the safety and long-term efficacy of super selective bronchial artery embolisation (ssBAE) using platinum coils in patients with haemoptysis is insufficient. The objective of the present study was to evaluate the safety and the 3-year postprocedure haemoptysis-free survival rate of de novo elective ssBAE using platinum coils rather than particles for the treatment of haemoptysis.
  
  
  
  A single-centre retrospective observational study.
  
  
  
  Hemoptysis and Pulmonary Circulation Center in Japan.
  
  
  
  A total of 489 consecutive patients with massive and non-massive haemoptysis who underwent de novo elective ssBAE without malignancy or haemodialysis.
  
  
  
  ssBAE using platinum coils. All patients underwent CT angiography before the procedure for identifying haemoptysis-related arteries (HRAs) and for procedural planning.
  
  
  
  The composite of the 3-year recurrence of haemoptysis and mortality from the day of the last ssBAE session. Each component of the primary end point and procedural success defined as successful embolisation of all target HRAs were also evaluated.
  
  
  
  The median patient age was 69 years, and 46.4% were men. The total number of target vessels was 4 (quartile 2-7), and the procedural success rate was 93.4%. There were 8 (1.6%) major complications: 1 aortic dissection, 2 symptomatic cerebellar infarctions and 5 mediastinal haematoma cases. The haemoptysis-free survival rates were estimated by the Kaplan-Meier analysis at 86.9% (95% CI 83.7% to 90.2%) at 1 year, 79.4% (74.8% to 84.3%) at 2 years and 57.6% (45.1% to 73.4%) at 3 years. Although not statistically significant by the adjusted analysis of variance with multiple imputation of missing variables, cryptogenic haemoptysis tended to show the most favourable outcome and non-tuberculous mycobacterium showed the worst outcome (adjusted p=0.250).
  
  
  
  We demonstrated the safety and long-term efficacy of elective ssBAE using platinum coils and established that it can be a valuable therapeutic option for treating patients with haemoptysis.
authors.affiliation: Hemoptysis and Pulmonary-Circulation Center, Kishiwada Eishinkai Hospital, Kishiwada, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Department of Clinical Epidemiology and Biostatics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hara
authors.affiliation: Hemoptysis and Pulmonary-Circulation Center, Kishiwada Eishinkai Hospital, Kishiwada, Japan.
authors.forename: Misaki
authors.initials: M
authors.lastname: Ryuge
authors.affiliation: Hemoptysis and Pulmonary-Circulation Center, Kishiwada Eishinkai Hospital, Kishiwada, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takafuji
authors.affiliation: Hemoptysis and Pulmonary-Circulation Center, Kishiwada Eishinkai Hospital, Kishiwada, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Youmoto
authors.affiliation: Department of Radiology, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Akira
authors.affiliation: Rakuwakai Kyoto Pulmonary Center, Rakuwakai Otowa Hospital, Kyoto, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nagasaka
authors.affiliation: Department of Clinical Epidemiology and Biostatics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Kabata
authors.affiliation: Department of Clinical Epidemiology and Biostatics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Clinical Epidemiology and Biostatics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Shintani
mesh_terms: D000368:Aged; D001981:Bronchial Arteries / Q000000981:diagnostic imaging; D000072226:Computed Tomography Angiography; D018572:Disease-Free Survival; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation; D005260:Female; D005500:Follow-Up Studies; D006469:Hemoptysis / Q000000981:diagnostic imaging / Q000382:microbiology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010984:Platinum; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D010984:Platinum
keywords: Bronchial artery embolization; Coil; Computed tomography angiography; Hemoptysis