title: The ETS-5 transcription factor regulates activity states inCaenorhabditis elegansby controlling satiety.
abstract: Animal behavior is shaped through interplay among genes, the environment, and previous experience. As in mammals, satiety signals induce quiescence inCaenorhabditis elegansHere we report that theC. eleganstranscription factor ETS-5, an ortholog of mammalian FEV/Pet1, controls satiety-induced quiescence. Nutritional status has a major influence onC. elegansbehavior. When foraging, food availability controls behavioral state switching between active (roaming) and sedentary (dwelling) states; however, when provided with high-quality food,C. elegansbecome sated and enter quiescence. We show that ETS-5 acts to promote roaming and inhibit quiescence by setting the internal "satiety quotient" through fat regulation. Acting from the ASG and BAG sensory neurons, we show that ETS-5 functions in a complex network with serotonergic and neuropeptide signaling pathways to control food-regulated behavioral state switching. Taken together, our results identify a neuronal mechanism for controlling intestinal fat stores and organismal behavioral states inC. elegans, and establish a paradigm for the elucidation of obesity-relevant mechanisms.
authors.affiliation: Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.|Biotech Research and Innovation Centre, University of Copenhagen, DK-2200 Copenhagen, Denmark.
authors.forename: Vaida
authors.initials: V
authors.lastname: Juozaityte
authors.affiliation: Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.|Biotech Research and Innovation Centre, University of Copenhagen, DK-2200 Copenhagen, Denmark.
authors.forename: David
authors.initials: D
authors.lastname: Pladevall-Morera
authors.affiliation: Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Podolska
authors.affiliation: Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.|Biotech Research and Innovation Centre, University of Copenhagen, DK-2200 Copenhagen, Denmark.
authors.forename: Steffen
authors.initials: S
authors.lastname: Nørgaard
authors.affiliation: Neuroscience Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.
authors.forename: Brent
authors.identifier: 0000-0002-7317-9385
authors.initials: B
authors.lastname: Neumann
authors.affiliation: Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia; roger.pocock@monash.edu.|Biotech Research and Innovation Centre, University of Copenhagen, DK-2200 Copenhagen, Denmark.
authors.forename: Roger
authors.initials: R
authors.lastname: Pocock
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000378:metabolism* / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D050783:Proto-Oncogene Proteins c-ets / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000378:metabolism / Q000502:physiology; D059326:Serotonergic Neurons / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; C575915:ETS-5 protein, C elegans; D009479:Neuropeptides; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors
keywords: ETS transcription factor; fat levels; neuronal signaling; quiescence; satiety