title: Elevated serum interferon γ-induced protein 10 kDa is associated with TAFRO syndrome.
abstract: Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology of HHV-8-negative MCD is idiopathic (iMCD). A distinct subtype of iMCD that shares a constellation of clinical features including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O) has been reported as TAFRO-iMCD, however the differences in cytokine profiles between TAFRO-iMCD and iMCD have not been established. We retrospectively compared levels of serum interferon γ-induced protein 10 kDa (IP-10), platelet-derived growth factor (PDGF)-AA, interleukin (IL)-10, and other cytokines between 11 cases of TAFRO-iMCD, 6 cases of plasma cell type iMCD, and 21 healthy controls. During flare-ups, patients with TAFRO-iMCD had significantly higher serum IP-10 and tended to have lower PDGF-AA levels than the other 2 groups. In addition, serum IL-10, IL-23, and vascular endothelial growth factor-A were elevated in both TAFRO-iMCD and iMCD. Elevated serum IP-10 is associated with inflammatory diseases including infectious diseases. There was a strong correlation between high serum IP-10 and the presence of TAFRO-iMCD, suggesting that IP-10 might be involved in the pathogenesis of TAFRO-iMCD.
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.|Hematology/Respiratory Medicine Kanazawa University Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Iwaki
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Gion
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Eisei
authors.initials: E
authors.lastname: Kondo
authors.affiliation: Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kawano
authors.affiliation: Department of Hematology, Chugoku Central Hospital, Fukuyama, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Masunari
authors.affiliation: Division of Clinical Infection Control and Prevention, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moro
authors.affiliation: Division of Hematology, Niigata City General Hospital, Niigata, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Nikkuni
authors.affiliation: Division of Hematology, Niigata City General Hospital, Niigata, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Takai
authors.affiliation: Department of Hematology, Eiju General Hospital, Tokyo, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Hagihara
authors.affiliation: Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hashimoto
authors.affiliation: Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Yokota
authors.affiliation: Department of Hematology and Medical Oncology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Okamoto
authors.affiliation: Hematology/Respiratory Medicine Kanazawa University Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.|Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005871:Castleman Disease / Q000097:blood* / Q000175:diagnosis; D054357:Chemokine CXCL10 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: C114753:CXCL10 protein, human; D054357:Chemokine CXCL10