title: Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms.
abstract: Markers of oxidative stress are increased in chronic obstructive pulmonary disease (COPD) and reactive oxygen species (ROS) are able to alter biological molecules, signaling pathways and antioxidant molecule function, many of which have been implicated in the pathogenesis of COPD. However, the involvement of ROS in the development and progression of COPD is not proven. Here, we discuss the sources of ROS, and the defences that have evolved to protect against their harmful effects. We address the role that ROS may have in the development and progression of COPD, as well as current therapeutic attempts at limiting the damage they cause. Evidence has indicated that the function of several key cells appears altered in COPD patients, and expression levels of important oxidant and antioxidant molecules may be abnormal. Therapeutic trials attempting to restore equilibrium to these molecules have not impacted upon all facets of disease and whilst the theory behind ROS influence in COPD appears sound, current models testing relevant pathways to tissue damage are limited. The heterogeneity seen in COPD patients presents a challenge to our understanding, and further research is essential to identify potential targets and stratified COPD patient populations where ROS therapies may be maximally efficacious.
authors.affiliation: Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK. mcguinna@bham.ac.uk.
authors.forename: Adam John Anthony
authors.initials: AJ
authors.lastname: McGuinness
authors.affiliation: Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK. sapeye@adf.bham.ac.uk.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sapey
keywords: COPD; antioxidant; antiproteinase; macrophage; mechanisms; neutrophil; oxidative stress; therapeutic studies