title: Complications in hepatic arterial infusion chemotherapy: retrospective comparison of catheter tip placement in the right/left hepatic artery vs. the gastroduodenal artery.
abstract: OBJECTIVE
  To compare the complication rates associated with hepatic arterial infusion chemotherapy (HAIC) for unresectable hepatocellular carcinoma (HCC) using two different catheter tip locations, the right/left hepatic artery (group 1) and the gastroduodenal artery (group 2).
  
  
  METHODS
  Between April 2001 and March 2015, 88 patients (group 1, n = 36; group 2, n = 52) with unresectable HCC, underwent HAIC via a transfemorally placed infusion catheter. The incidence of complications related to catheter placement (including hepatic arterial occlusion, catheter dislocation, non-target embolization and port-catheter system infection) as well as catheter patency and patient survival were evaluated.
  
  
  RESULTS
  The technical success rate was 100%. The overall complication rate was 17% (15/88 patients). The specific complications were as follows: hepatic artery occlusion, n = 1 (group 2, n = 1), gastroduodenal ulcer, n = 6 (group 1, n = 2; group 2, n = 4); catheter dislocation, n = 1 (group 2, n = 1); port-catheter system infection, n = 3 (group 2, n = 3); and bleeding at the puncture site, n = 4 (group 1, n = 1; group 2, n = 3).
  
  
  CONCLUSIONS
  The complication rates in groups 1 and 2 did not differ to a statistically significant extent.
authors.affiliation: Department of Radiology, Kyoto University Graduate School of Medicine, 54-Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
authors.forename: Rinpei
authors.initials: R
authors.lastname: Imamine
authors.affiliation: Department of Radiology, Kyoto University Graduate School of Medicine, 54-Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan. ksj@kuhp.kyoto-u.ac.jp.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Shibata
authors.affiliation: Department of Radiology, Kyoto University Graduate School of Medicine, 54-Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shinozuka
authors.affiliation: Department of Radiology, Kyoto University Graduate School of Medicine, 54-Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Togashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001158:Arteries; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality; D002406:Catheterization, Peripheral / Q000009:adverse effects* / Q000379:methods*; D004386:Duodenum / Q000098:blood supply*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects* / Q000379:methods*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013270:Stomach / Q000098:blood supply*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents
keywords: Complications; HAIC; HCC