title: Carbonic anhydrase I and II autoantibodies in Behçet's disease.
abstract: BACKGROUND
  Behçet's disease is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase (CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in Behçet's disease (BD).
  
  
  METHODS
  35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA.
  
  
  RESULTS
  The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p=0.013, p inf 0.0001, respectively). A cut-off value of 0.250 ABSU for anti-CA I was associated with 34 % sensitivity and 100 % specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54 % sensitivity and 100 % specificity for predicting BD.
  
  
  CONCLUSIONS
  The CA I and II autoantibody levels in patients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BD.
authors.affiliation: Faculty of Medicine, Karadeniz Technical University.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.affiliation: Faculty of Medicine, Karadeniz Technical University.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.affiliation: Faculty of Health Sciences, Karadeniz Technical University.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: School of Health Services, Recep Tayyip Erdogan University.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Sumer
authors.affiliation: Faculty of Medicine, Karadeniz Technical University.
authors.forename: Serap
authors.initials: S
authors.lastname: Ozer Yaman
authors.affiliation: Faculty of Medicine, Karadeniz Technical University.
authors.forename: Murat
authors.initials: M
authors.lastname: Karkucak
authors.affiliation: Fatih State Hospital.
authors.forename: Arzu
authors.initials: A
authors.lastname: Aydin Capkin
authors.affiliation: Ulubey Vocational School, Ordu University.
authors.forename: Diler
authors.initials: D
authors.lastname: Us Altay
authors.affiliation: Faculty of Engineering and Natural Sciences, Gumushane University.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Turan
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001528:Behcet Syndrome / Q000097:blood* / Q000201:enzymology / Q000276:immunology; D024401:Carbonic Anhydrase I / Q000097:blood*; D024402:Carbonic Anhydrase II / Q000097:blood*; D006801:Humans
chemical_list: D001323:Autoantibodies; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II