title: Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana.
abstract: The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved thatI Eshowed high anti-bacterial activity whereasI Ishowed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.
authors.affiliation: Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. asthagiri.herbal@gmail.com.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Narasimhan
authors.affiliation: Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. mahesh7605@yahoo.co.in.
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Maheshwaran
authors.affiliation: Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666 Sharjah, United Arab Emirates. iabuyousef@aus.edu.
authors.forename: Imad A
authors.initials: IA
authors.lastname: Abu-Yousef
authors.affiliation: Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666 Sharjah, United Arab Emirates. amajdalawieh@aus.edu.
authors.forename: Amin F
authors.initials: AF
authors.lastname: Majdalawieh
authors.affiliation: Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. rethavathij@gmail.com.
authors.forename: Janarthanam
authors.initials: J
authors.lastname: Rethavathi
authors.affiliation: Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. prince.ahrf@gmail.com.
authors.forename: Prince Edwin
authors.initials: PE
authors.lastname: Das
authors.affiliation: Institute of Sciences of Food Productions, CNR-ISPA, Lecce 73100, Italy. palmiro.poltronieri@ispa.cnr.it.
authors.forename: Palmiro
authors.initials: P
authors.lastname: Poltronieri
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D029762:Garcinia mangostana / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D044004:Xanthones / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D044004:Xanthones; C021053:mangostin
keywords: anti-bacterial; anti-fungal; biomedical device; packaging; semi-synthetic modification; textiles; α-mangostin