title: The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours.
abstract: Galanin is a 29 amino acid neuropeptide widely distributed in neurons within the central nervous system. Galanin exerts its biological activities through three different G protein-receptors and participates in a number of functions, including mood regulation. Not only Galanin but also Galanin N-terminal fragments like Galanin(1-15) are active at the central level. In this work, we review the latest findings in studies on Galanin and Galanin(1-15) in depression-related behaviours. Our focus is on animal models for depression, and we pay some attention to research data obtained in human studies. Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Departamento de Fisiología, Campus de Teatinos s/n, 29071 Málaga, Spain. Electronic address: carmelomp@uma.es.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Millón
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Departamento de Fisiología, Campus de Teatinos s/n, 29071 Málaga, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Flores-Burgess
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Departamento de Fisiología, Campus de Teatinos s/n, 29071 Málaga, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Narváez
authors.affiliation: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors.forename: Dasiel O
authors.initials: DO
authors.lastname: Borroto-Escuela
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Departamento de Fisiología, Campus de Teatinos s/n, 29071 Málaga, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Gago
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Departamento de Psicobiología, Campus de Teatinos s/n, 29071 Málaga, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Santín
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Departamento de Psicobiología, Campus de Teatinos s/n, 29071 Málaga, Spain.
authors.forename: Estela
authors.initials: E
authors.lastname: Castilla-Ortega
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Departamento de Fisiología, Campus de Teatinos s/n, 29071 Málaga, Spain.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Narváez
authors.affiliation: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
authors.affiliation: Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Departamento de Fisiología, Campus de Teatinos s/n, 29071 Málaga, Spain.
authors.forename: Zaida
authors.initials: Z
authors.lastname: Díaz-Cabiale
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D003863:Depression / Q000378:metabolism*; D003866:Depressive Disorder / Q000378:metabolism; D019004:Galanin / Q000378:metabolism*; D006801:Humans; D009479:Neuropeptides / Q000378:metabolism*; D044088:Receptors, Galanin / Q000378:metabolism*
chemical_list: D009479:Neuropeptides; D044088:Receptors, Galanin; D019004:Galanin
keywords: Depression; Galanin