title: Synthesis, mechanical and thermal rheological properties of new gellan gum derivatives.
abstract: New derivatives of gellan gum (GG) were prepared by covalent attachment of octadecylamine (C18-NH2) to polysaccharide backbone via amide linkage by using bis(4-nitrophenyl) carbonate (4-NPBC) as a coupling agent. The effect of the alkyl chain grafted onto hydrophilic backbone of high molecular weight GG was investigated in terms of physicochemical properties and ability of new derivatives to form hydrogels. A series of hydrogels was obtained in solutions with different kind and concentration of ions and their stability and mechanical properties were evaluated. The obtained derivatives resulted soluble at temperature lower than starting GG and physicochemical properties of obtained hydrogels suggested their potential use in biomedical field.
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Agnello
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909, Taipas, Guimarães, Portugal.
authors.forename: Luca
authors.initials: L
authors.lastname: Gasperini
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909, Taipas, Guimarães, Portugal; Department of Chemistry, CICECO, Aveiro Institute of Materials, University of Aveiro, 2810-193, Aveiro, Portugal.
authors.forename: João F
authors.initials: JF
authors.lastname: Mano
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy. Electronic address: giovanna.pitarresi@unipa.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Pitarresi
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy.
authors.forename: Fabio S
authors.initials: FS
authors.lastname: Palumbo
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909, Taipas, Guimarães, Portugal.
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy; Institute of Biophysics at Palermo, Italian National Research Council, Via Ugo La Malfa 153, 90146, Palermo, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Giammona
mesh_terms: D000588:Amines / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D009596:Nitrophenols / Q000737:chemistry; D011135:Polysaccharides, Bacterial / Q000138:chemical synthesis* / Q000737:chemistry; D012212:Rheology; D013696:Temperature; D023822:Tissue Engineering
chemical_list: D000588:Amines; D002254:Carbonates; D020100:Hydrogels; D009596:Nitrophenols; D011135:Polysaccharides, Bacterial; C024719:4-nitrophenyl; C048288:gellan gum; C009317:stearylamine
keywords: Gellan gum; Mechanical properties; Octadecylamine; Physical hydrogels; Thermal scanning rheology