title: Roles of Sumoylation in mRNA Processing and Metabolism.
abstract: SUMO has gained prominence as a regulator in a number of cellular processes. The roles of sumoylation in RNA metabolism, however, while considerable, remain less well understood. In this chapter we have assembled data from proteomic analyses, localization studies and key functional studies to extend SUMO's role to the area of mRNA processing and metabolism. Proteomic analyses have identified multiple putative sumoylation targets in complexes functioning in almost all aspects of mRNA metabolism, including capping, splicing and polyadenylation of mRNA precursors. Possible regulatory roles for SUMO have emerged in pre-mRNA 3' processing, where SUMO influences the functions of polyadenylation factors and activity of the entire complex. SUMO is also involved in regulating RNA editing and RNA binding by hnRNP proteins, and recent reports have suggested the involvement of the SUMO pathway in mRNA export. Together, these reports suggest that SUMO is involved in regulation of many aspects of mRNA metabolism and hold the promise for exciting future studies.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Richard
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
authors.forename: Vasupradha
authors.initials: V
authors.lastname: Vethantham
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, 10027, USA. jlm2@columbia.edu.
authors.forename: James L
authors.initials: JL
authors.lastname: Manley
mesh_terms: D000818:Animals; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000378:metabolism; D006801:Humans; D026721:RNA 3' End Processing; D012315:RNA Caps / Q000378:metabolism; D017393:RNA Editing; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D058207:Sumoylation; D014158:Transcription, Genetic
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012315:RNA Caps; D012322:RNA Precursors; D012333:RNA, Messenger; D025841:Small Ubiquitin-Related Modifier Proteins
keywords: 3’-end processing; Capping; RNA editing; Splicing; Transcription; mRNA