title: Occupational exposure to pesticides and other biocides and risk of thyroid cancer.
abstract: To assess the associations between occupational exposure to biocides and pesticides and risk of thyroid cancer.
  
  
  
  Using data from a population-based case-control study involving 462 incident thyroid cancer cases and 498 controls in Connecticut collected in 2010-2011, we examined the association with occupational exposure to biocides and pesticides through a job-exposure matrix. We used unconditional logistic regression models to estimate OR and 95% CI, adjusting for potential confounders.
  
  
  
  Individuals who were occupationally ever exposed to biocides had an increased risk of thyroid cancer (OR=1.65, 95% CI 1.16 to 2.35), and the highest risk was observed for the high cumulative probability of exposure (OR=2.18, 95% CI 1.28 to 3.73). The observed associations were similar when we restricted to papillary thyroid cancer and well-differentiated thyroid cancer. Stronger associations were observed for thyroid microcarcinomas (tumour size ≤1 cm). No significant association was observed for occupational exposure to pesticides.
  
  
  
  Our study provides the first evidence linking occupational exposure to biocides and risk of thyroid cancer. The results warrant further investigation.
authors.affiliation: Chongqing Safety Engineering Institute, Chongqing University of Science and Technology, Chongqing, China.|Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
authors.forename: Fanhua
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Lerro
authors.affiliation: Department of Environmental and Occupational Health, University of Montreal, Montreal, Canada.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lavoué
authors.affiliation: Department of Surgery, Section of Surgical Outcomes and Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA.
authors.forename: Huang
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Environmental and Occupational Health, University of Montreal, Montreal, Canada.
authors.forename: Jack
authors.initials: J
authors.lastname: Siemiatycki
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.affiliation: Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
authors.forename: Shuangge
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Deziel
authors.affiliation: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Friesen
authors.affiliation: Department of Surgery and Yale Cancer Center, Yale School of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Udelsman
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.|Department of Surgery, Section of Surgical Outcomes and Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000139:chemically induced* / Q000453:epidemiology*; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D004202:Disinfectants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations; D010575:Pesticides / Q000009:adverse effects*; D012042:Registries; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000139:chemically induced* / Q000453:epidemiology* / Q000473:pathology
chemical_list: D004202:Disinfectants; D010575:Pesticides
keywords: job-exposure matrix; occupational exposure; thyroid cancer