title: Columnar Self-Assemblies of Triarylamines as Scaffolds for Artificial Biomimetic Channels for Ion and for Water Transport.
abstract: Triarylamine molecules appended with crown-ethers or carboxylic moieties form self-assembled supramolecular channels within lipid bilayers. Fluorescence assays and voltage clamp studies reveal that the self-assemblies incorporating the crown ethers work as single channels for the selective transport of K+or Rb+. The X-ray crystallographic structures confirm the mutual columnar self-assembly of triarylamines and crown-ethers. The dimensional fit of K+cations within the 18-crown-6 leads to a partial dehydration and to the formation of alternating K+cation-water wires within the channel. This original type of organization may be regarded as a biomimetic alternative of columnar K+-water wires observed for the natural KcsA channel. Supramolecular columnar arrangement was also shown for the triarylamine-carboxylic acid conjugate. In this latter case, stopped-flow light scattering analysis reveals the transport of water across lipid bilayer membranes with a relative water permeability as high as 17 μm s-1.
authors.affiliation: ISIS, Institut de Science et d'Ingénierie Supramoléculaires , 8 allée Gaspard Monge, 67000 Strasbourg, France.|SAMS Research Group, University of Strasbourg , Institut Charles Sadron, CNRS, 23 rue du Loess, BP 84047, 67034 Strasbourg Cedex 2, France.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schneider
authors.affiliation: Adaptive Supramolecular Nanosystems Group, Institut Europèen des Membranes , ENSCM-UMII-CNRS UMR-5635, Place Eugène Bataillon, CC 047, F-34095 Montpellier, France.
authors.forename: Erol-Dan
authors.initials: ED
authors.lastname: Licsandru
authors.affiliation: Adaptive Supramolecular Nanosystems Group, Institut Europèen des Membranes , ENSCM-UMII-CNRS UMR-5635, Place Eugène Bataillon, CC 047, F-34095 Montpellier, France.
authors.forename: Istvan
authors.initials: I
authors.lastname: Kocsis
authors.affiliation: Adaptive Supramolecular Nanosystems Group, Institut Europèen des Membranes , ENSCM-UMII-CNRS UMR-5635, Place Eugène Bataillon, CC 047, F-34095 Montpellier, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Gilles
authors.affiliation: Adaptive Supramolecular Nanosystems Group, Institut Europèen des Membranes , ENSCM-UMII-CNRS UMR-5635, Place Eugène Bataillon, CC 047, F-34095 Montpellier, France.
authors.forename: Florina
authors.initials: F
authors.lastname: Dumitru
authors.affiliation: SAMS Research Group, University of Strasbourg , Institut Charles Sadron, CNRS, 23 rue du Loess, BP 84047, 67034 Strasbourg Cedex 2, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Moulin
authors.affiliation: SAMS Research Group, University of Strasbourg , Institut Charles Sadron, CNRS, 23 rue du Loess, BP 84047, 67034 Strasbourg Cedex 2, France.
authors.forename: Junjun
authors.initials: J
authors.lastname: Tan
authors.affiliation: ISIS, Institut de Science et d'Ingénierie Supramoléculaires , 8 allée Gaspard Monge, 67000 Strasbourg, France.
authors.forename: Jean-Marie
authors.identifier: 0000-0001-8981-4593
authors.initials: JM
authors.lastname: Lehn
authors.affiliation: SAMS Research Group, University of Strasbourg , Institut Charles Sadron, CNRS, 23 rue du Loess, BP 84047, 67034 Strasbourg Cedex 2, France.
authors.forename: Nicolas
authors.identifier: 0000-0003-4093-3000
authors.initials: N
authors.lastname: Giuseppone
authors.affiliation: Adaptive Supramolecular Nanosystems Group, Institut Europèen des Membranes , ENSCM-UMII-CNRS UMR-5635, Place Eugène Bataillon, CC 047, F-34095 Montpellier, France.
authors.forename: Mihail
authors.identifier: 0000-0003-0042-9483
authors.initials: M
authors.lastname: Barboiu