title: Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.
abstract: Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39's sequenced genome revealed the macrotermycin's putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute , 07745 Jena, Germany.
authors.forename: Christine
authors.identifier: 0000-0002-9747-3423
authors.initials: C
authors.lastname: Beemelmanns
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Ramadhar
authors.affiliation: Natural Product Research Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Ki Hyun
authors.identifier: 0000-0002-5285-9138
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Molecular & Cell Biology, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Jonathan L
authors.identifier: 0000-0003-1745-8838
authors.initials: JL
authors.lastname: Klassen
authors.affiliation: Daniel K. Inouye College of Pharmacy, University of Hawaii , Hilo, Hawaii 96720, United States.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Wyche
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Centre for Social Evolution, Section for Ecology and Evolution, Department of Biology, University of Copenhagen , 2100 Copenhagen East, Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Poulsen
authors.forename: Tim S
authors.identifier: 0000-0002-4502-3084
authors.initials: TS
authors.lastname: Bugni
authors.forename: Cameron R
authors.initials: CR
authors.lastname: Currie
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000192:Actinomycetales; D000818:Animals; D000900:Anti-Bacterial Agents; D006031:Glycosylation; D020049:Isoptera; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents