title: [Clinical efficacy of pulmonary surfactant combined with budesonide for preventing bronchopulmonary dysplasia in very low birth weight infants].
abstract: OBJECTIVE
  To explore the clinical efficacy of intratracheal instillation of pulmonary surfactant (PS) combined with budesonide for preventing bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants.
  
  
  METHODS
  Thirty VLBW infants with gestational age <32 weeks who developed neonatal respiratory distress syndrome (NRDS) (grade III-IV) suffering from intrauterine infection were randomly assigned into a PS + budesonide group and a PS alone group. The changes were compared between the two groups in arterial blood gas indexes, oxygenation index (OI), duration of mechanical ventilation, duration of oxygen supplementation, incidence of BPD, mortality rate at 36 weeks corrected gestational age and incidences of other complications except BPD.
  
  
  RESULTS
  Compared with the PS alone group, the PS+budesonide group had a lower incidence of BPD, shorter duration of mechanical ventilation and oxygen supplementation (P<0.05). On the 2nd to 6th day after treatment, the PS+budesonide group had higher pH value of arterial blood gas and OI and lower carbon dioxide partial pressure compared with the PS alone group (P<0.05). There were no significant differences in the mortality rate at 36 weeks corrected gestational age and the incidences of other complications except BPD between the two groups (P>0.05).
  
  
  CONCLUSIONS
  Intratracheal instillation of PS combined with budesonide can effectively reduce the incidence of BPD in VLBW premature infants with severe NRDS.
authors.affiliation: Department of Pediatrics, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China. chenmingwu01@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Pan
authors.forename: Ming-Wu
authors.initials: MW
authors.lastname: Chen
authors.forename: Wen-Quan
authors.initials: WQ
authors.lastname: Ni
authors.forename: Tao
authors.initials: T
authors.lastname: Fang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen
authors.forename: Jia-Hua
authors.initials: JH
authors.lastname: Pan
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000517:prevention & control*; D019819:Budesonide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*
chemical_list: D011663:Pulmonary Surfactants; D019819:Budesonide