title: Targeted therapy in older women with breast cancer - What's the target?
abstract: In this review, the results of the FOCUS (Female breast cancer in the elderly: Optimizing Clinical guidelines USing clinico-pathological and molecular data) program are summarized. This study was originally designed with the aim to define guidelines for the treatment of older women with breast cancer. With data from several studies within FOCUS, a prediction model can be constructed. Such a model helps to define individualized treatment for older patients with breast cancer, taking into account tumour characteristics and patient-related factors. At a clinical level, this model can provide the physician and the patient with accurate prediction to assist on the decision making of treatment strategies: this results into individualized treatment, not based on one individual marker, but on different pillars related to the patient, the tumour and the most suitable, appropriate treatment.
authors.affiliation: Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands; Department of Geriatrics and Gerontology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Kiderlen
authors.affiliation: Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: C J H
authors.initials: CJH
authors.lastname: van de Velde
authors.affiliation: Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: g.j.liefers@lumc.nl.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Liefers
mesh_terms: D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D017410:Practice Guidelines as Topic; D057285:Precision Medicine; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D015996:Survival Rate
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human
keywords: Breast cancer; Geriatric oncology