title: Molecular characterization and clinical epidemiology of human respiratory syncytial virus (HRSV) A and B in hospitalized children, Southern Brazil.
abstract: Human respiratory syncytial virus (HRSV) is a major etiologic agent of pediatric respiratory infections. Genetic variability of its glycoprotein G enables HRSV to evade the immune response and determines its seasonal dissemination. This study reports genetic variability and clinical profiles of HRSV-infected patients from Southern Brazil. Seventy positive samples, 78% type A and 22% type B, were analyzed. Of the patients (median age, 6 months; interquartile range, 2-11 years), 16% had co-morbidities and 17% developed severe disease. The ON1 HRSV genotype first appeared in 2012, and patients infected with this genotype showed an increased tendency to develop severe disease.
authors.affiliation: Postgraduate Program in Microbiology, Parasitology and Pathology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors.forename: Francielli B
authors.initials: FB
authors.lastname: Moreira
authors.affiliation: Department of Pediatrics, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors.forename: Cristine S
authors.initials: CS
authors.lastname: Rosario
authors.affiliation: Postgraduate Program in Internal Medicine and Health Science, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors.forename: Jucelia S
authors.initials: JS
authors.lastname: Santos
authors.affiliation: Postgraduate Program in Internal Medicine and Health Science, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors.forename: Valéria M
authors.initials: VM
authors.lastname: Avanzi
authors.affiliation: Virology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors.forename: Meri Bordignon
authors.initials: MB
authors.lastname: Nogueira
authors.affiliation: Virology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors.forename: Luine R
authors.initials: LR
authors.lastname: Vidal
authors.affiliation: Postgraduate Program in Microbiology, Parasitology and Pathology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.|Postgraduate Program in Internal Medicine and Health Science, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.|Virology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors.forename: Sonia Mara
authors.identifier: 0000-0001-7907-7585
authors.initials: SM
authors.lastname: Raboni
mesh_terms: D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D018357:Respiratory Syncytial Virus Infections / Q000473:pathology* / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*
keywords: genetic variability; genotype; glycoprotein; respiratory virus