title: Molecular hydrogen: a therapeutic antioxidant and beyond.
abstract: Molecular hydrogen (H2) medicine research has flourished since a landmark publication inNature Medicinethat revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydroxyl radicals scavenging. The non-toxicity at high concentrations and rapid cellular diffusion features of molecular hydrogen ensure the feasibility and readiness of its clinical translation to human patients.
authors.affiliation: Department of Anesthesiology, Loma Linda University, Loma Linda, CA, USA; Department of Basic Sciences, Division of Physiology, Loma Linda University, Loma Linda, CA, USA.
authors.forename: Lei
authors.identifier: 0000-0002-7211-8337
authors.initials: L
authors.lastname: Huang
keywords: anti-apoptosis; anti-inflammation; biological effect; clinical application; free radical scavenger; hydrogen gas; hydrogen-oxygen nebulizer machine; hydrogen-saturated water/saline