title: Prevalence of allergen sensitization in 1000 adults in Saskatchewan.
abstract: BACKGROUND
  The prevalence of sensitization varies geographically based on multiple environmental factors including humidity. The aim of this study was to determine the prevalence of atopy in symptomatic adults. More importantly we aimed to obtain a regional statistic of sensitization to common allergens given Saskatchewan's dry climate.
  
  
  METHODS
  One thousand consecutive symptomatic adults were screened for atopy via skin prick test over 10 years (2006-2016) in the Division of Respirology. An atopic screen was performed with twenty common aeroallergens by a single investigator, Dr. D. Cockcroft. A positive test was considered to be a wheal ≥3 mm and markedly positive reactions ≥8 mm were also documented.
  
  
  RESULTS
  The prevalence of atopy by means of a positive skin test (≥3 mm) was 45.5%. The prevalence of one or more markedly positive reactions (≥8 mm) was 29.5% of the total population. The most frequent sensitization was to cat dander (58.2%), followed by mixed grass (32.1%), and birch (26.8%). Dust mite sensitization was 22.4% and mouse 6.2%. A positive epidemiology screen for cat/grass/mite would have incorporated 82.0% (n = 373) of subjects with positive skin tests. Those who failed the cat/grass/mite screen were mainly sensitized to trees (n = 34), molds (n = 22), weeds (n = 7), and animals (n = 8).
  
  
  CONCLUSIONS
  There is a high prevalence of cat sensitization in Saskatchewan, much higher than recorded in other centers internationally. This is likely due to a high proportion of cat ownership. The prevalence of mite sensitization is lower than those mentioned at other centres likely due to Saskatchewan's dry climate. The significance of the rate of markedly positive reactions (≥8 mm wheal) when compared to humid areas with higher burden of mite is unknown. There is a low prevalence of roach also likely due to the dry climate and mouse sensitization was low but still identified as a significant indoor allergen. A cat/grass/mite screen may be useful with a 82.0% sensitivity.
authors.affiliation: Department of Internal Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK S7N 0W8 Canada.
authors.forename: Stacey D
authors.initials: SD
authors.lastname: Lok
authors.affiliation: Department of Internal Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK S7N 0W8 Canada.|Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan, 5th Floor Ellis Hall, 103 Hospital Drive, Saskatoon, SK S7N 0W8 Canada.
authors.forename: Beth E
authors.initials: BE
authors.lastname: Davis
authors.affiliation: Department of Internal Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK S7N 0W8 Canada.|Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan, 5th Floor Ellis Hall, 103 Hospital Drive, Saskatoon, SK S7N 0W8 Canada.
authors.forename: Donald W
authors.initials: DW
authors.lastname: Cockcroft
keywords: Asthma; Epidemiology; Hypersensitivity; Skin tests