title: Non-healing tongue ulcer in a rheumatoid arthritis patient medicated with leflunomide. An adverse drug event?
abstract: Leflunomide is a member of the disease modifying anti-rheumatic drugs group used as a treatment modality in active rheumatoid and psoriatic arthritis. "Oral ulcers" are reported in 3-5% of leflunomide medicated rheumatoid arthritis patients with adverse events, but they are not described in detail in the literature. We present a case of an ulcer in the tongue of a rheumatoid arthritis patient managed with leflunomide and contemplate on its pathogenesis.Key words:Leflunomide, oral ulcer, DHODH.
authors.affiliation: DDS, MSc, Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Eleni-Marina
authors.initials: EM
authors.lastname: Kalogirou
authors.affiliation: DDS, MSc, Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Katsoulas
authors.affiliation: DDS, PhD, Assistant Professor, Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tosios
authors.affiliation: MD, PhD, Professor, 1st Department of Pathology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Andreas C
authors.initials: AC
authors.lastname: Lazaris
authors.affiliation: DDS, MSc, PhD, Professor, Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Sklavounou