title: The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis.
abstract: The outcomes of studies analyzing the prognostic role of CTLA-4 in cancers are controversial. Therefore, the aim of our meta-analysis was to clarify the correlation between CTLA-4 expression and OS in different cancer cases. Relevant literature was searched using PubMed, EMBASE, Web of Science, and the Cochrane Library. The clinicopathological features, hazard ratio (HR) and 95% confidence intervals (CI) were collected from these studies and were analyzed using Stata version 12.0 software. The pooled HR values showed no significant correlation between CTLA-4 expression levels and OS in relation to tumors (HR: 1.24, 95% CI: 0.98-1.56, I2 = 71.7%, P = 0.000). Further subgroup analyses were conducted and categorized by experimental methods, CTLA-4 sources and cancer types. The survey showed a significant correlation (HR: 1.47, 95% CI: 1.14-1.89) between high expression of CTLA-4 and OS in the SNP subgroup, and subgroups analyzing by PCR (HR: 1.50, 95% CI: 1.20-1.86) and flow cytometry (HR: 2.76, 95% CI: 1.49-5.14). In addition, our analysis observed significant differences between patients and controls in inCTLA-4+CD4+ lymphocytes, surCTLA-4+CD4+ lymphocytes, inCTLA-4+CD8+ lymphocytes, and surCTLA-4+CD8+ lymphocytes. Knowledge of the effects of CTLA-4 could potentially be used to effectively guide appropriate prognosis and therapeutic strategies in cancer patients.
authors.affiliation: Department of Radiation Oncology, Qianfoshan hospital affiliated to Shandong University, 16766 Jingshi Road, Jinan, 250014, P.R. China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Hu
authors.affiliation: Department of Radiation Oncology, Qianfoshan hospital affiliated to Shandong University, 16766 Jingshi Road, Jinan, 250014, P.R. China.
authors.forename: Qiqi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Qianfoshan hospital affiliated to Shandong University, 16766 Jingshi Road, Jinan, 250014, P.R. China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Deng
authors.affiliation: Division of Oncology, Department of Graduate, Weifang Medical College, 7166 Baotongxi Road, Weifang, 261053, P.R. China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Qianfoshan hospital affiliated to Shandong University, 16766 Jingshi Road, Jinan, 250014, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Liang
authors.affiliation: Department of Radiation Oncology, Qianfoshan hospital affiliated to Shandong University, 16766 Jingshi Road, Jinan, 250014, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Radiation Oncology, Qianfoshan hospital affiliated to Shandong University, 16766 Jingshi Road, Jinan, 250014, P.R. China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D060908:CTLA-4 Antigen / Q000378:metabolism*; D016208:Databases, Factual; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human