title: P2X71513 A>C Polymorphism Confers Increased Risk of Extrapulmonary Tuberculosis: A Meta-analysis of Case-Control Studies.
abstract: The association of A1513C (rs3751143) polymorphism ofP2X7gene with the risk of extrapulmonary tuberculosis (EPTB) has been extensively analyzed, but no consensus has been achieved. In this study, a meta-analysis was done to assess this precise association. Online web databases, like PubMed (MEDLINE) and EMBASE were searched for pertinent reports showing association ofP2X7A1513C polymorphism with EPTB risk. To assess the strength of this association, we calculated pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of eight reports involving 2237controls and 594 EPTB cases were included in this study. Four genetic models,viz.allele (C vs. A: p=0.011; OR= 1.677, 95% CI = 1.125-2.501), homozygous (CC vs. AA: p = 0.053; OR= 2.362, 95% CI = 0.991-5.632), heterozygous (AC vs. AA: p = 0.003; OR= 1.775, 95% CI = 1.209-2.607) and dominant (CC + AC vs. AA: p = 0.005; OR= 1.890, 95% CI = 1.207-2.962) showed significant associations compared with wild type genotypes. Subgroup analysis stratified by ethnicity was also performed and the results suggested that homozygous and heterozygous genotypes were associated significantly with increased susceptibility of EPTB in Asian population. Similarly, heterozygous and dominant models showed increased EPTB risk in Caucasian population. The present meta-analysis suggests thatP2X7A1513C polymorphism may be an important risk factor for EPTB. Also, our sub-group analysis indicates thatP2X7A1513C polymorphism confers increased EPTB risk among Asians and Caucasians. However, future larger studies are needed to provide more precise conclusion and endorse the present results.
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
authors.forename: Mohammed Y
authors.initials: MY
authors.lastname: Areeshi
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
authors.forename: Raju K
authors.initials: RK
authors.lastname: Mandal
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia; The University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi - 110095, India.
authors.forename: Sajad
authors.initials: S
authors.lastname: Dar
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia; Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi-110025, India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Wahid
authors.affiliation: Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India.
authors.forename: Md Ekhlaque A
authors.initials: ME
authors.lastname: Khan
authors.affiliation: Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Panda
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
authors.forename: Arshad
authors.initials: A
authors.lastname: Jawed
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia; Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi-110025, India.
authors.forename: Shafiul
authors.initials: S
authors.lastname: Haque
keywords: Extrapulmonary tuberculosis; P2X7 gene; genetic models; meta-analysis; polymorphism