title: Pneumocystiscolonization in asthmatic patients not receiving oral corticosteroid therapy.
abstract: Pneumocystis jiroveciican colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene ofP. jirovecii.2 patients (20%) hadPneumocystisDNA detected; 1 patient had 3 positive samples over an 11-day period. Thus,Pneumocystiscolonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.
  
  
  
  NCT01113034.
authors.affiliation: Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Davey
authors.affiliation: Division of Infectious Diseases, Augusta University, Augusta, Georgia, USA.
authors.forename: Rhonda E
authors.initials: RE
authors.lastname: Colombo
authors.affiliation: Division of Clinical Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Fiorentino
authors.affiliation: Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Fahle
authors.affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Davey
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.|Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Olivier
authors.affiliation: Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kovacs
mesh_terms: D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000627:therapeutic use*; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000382:microbiology*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011010:Pneumocystis / Q000254:growth & development*; D013183:Sputum / Q000382:microbiology; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Asthma; Lung Diseases