title: The Tumor Microenvironment at a Turning Point Knowledge Gained Over the Last Decade, and Challenges and Opportunities Ahead: A White Paper from the NCI TME Network.
abstract: Over the past 10 years, the Tumor Microenvironment Network (TMEN), supported by the NCI (Bethesda, MD), has promoted collaborative research with the explicit goal of fostering multi-institutional and transdisciplinary groups that are capable of addressing complex issues involving the tumor microenvironment. The main goal of the TMEN was to generate novel information about the dynamic complexity of tumor-host interactions in different organ systems with emphasis on using human tissues and supplemented by experimental models. As this initiative comes to a close, members of the TMEN took time to examine what has been accomplished by the Network and importantly to identify the challenges and opportunities ahead. This consensus document summarizes for the broader scientific community discussions that occurred at the two final meetings of the TMEN in 2015 and 2016.Cancer Res; 77(5); 1051-9. ©2017 AACR.
authors.affiliation: Department of Pediatrics, University of Southern California and The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California. declerck@usc.edu singerd@mail.nih.gov.|Department of Biochemistry & Molecular Biology, University of Southern California, Los Angeles, California.
authors.forename: Yves A
authors.initials: YA
authors.lastname: DeClerck
authors.affiliation: Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Pharmacology & Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Pienta
authors.affiliation: Division of Cancer Biology, NCI, NIH, Bethesda, Maryland.
authors.forename: Elisa C
authors.initials: EC
authors.lastname: Woodhouse
authors.affiliation: Division of Cancer Biology, NCI, NIH, Bethesda, Maryland. declerck@usc.edu singerd@mail.nih.gov.
authors.forename: Dinah S
authors.initials: DS
authors.lastname: Singer
authors.affiliation: Division of Cancer Biology, NCI, NIH, Bethesda, Maryland.
authors.forename: Suresh
authors.initials: S
authors.lastname: Mohla
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment / Q000502:physiology*