title: Guiding osteogenesis of mesenchymal stem cells using carbon-based nanomaterials.
abstract: In the field of regenerative medicine, stem cells are highly promising due to their innate ability to generate multiple types of cells that could replace/repair damaged parts of human organs and tissues. It has been reported that both in vitro and in vivo function/survival of stem cells could significantly be improved by utilizing functional materials such as biodegradable polymers, metal composites, nanopatterns and nanohybrid particles. Of various biocompatible materials available for use in stem cell-based therapy and research, carbon-based materials-including fullerenes graphene/graphene oxide and carbon nanotubes-have been found to possess unique physicochemical characteristics that contribute to the effective guidance of stem cell differentiation into specific lineages. In this review, we discuss a number of previous reports that investigated the use of carbon-based materials to control stem cell behavior, with a particular focus on their immense potential to guide the osteogenesis of mesenchymal stem cells (MSCs). We hope that this review will provide information on the full potential of using various carbon-based materials in stem cell-mediated regenerative therapy, particularly for bone regeneration and repair.
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
authors.forename: Ee-Seul
authors.initials: ES
authors.lastname: Kang
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
authors.forename: Da-Seul
authors.initials: DS
authors.lastname: Kim
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
authors.forename: Intan Rosalina
authors.initials: IR
authors.lastname: Suhito
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
authors.forename: Sung-Sik
authors.initials: SS
authors.lastname: Choo
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
authors.forename: Inbeom
authors.initials: I
authors.lastname: Song
authors.affiliation: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
authors.forename: Tae-Hyung
authors.initials: TH
authors.lastname: Kim