title: Partial versus early full weight bearing after uncemented total hip arthroplasty: a meta-analysis.
abstract: BACKGROUND
  This meta-analysis aimed to investigate the efficacy and safety of partial weight bearing (PWB) versus early full weight bearing (FWB) after uncemented total hip arthroplasty (THA).
  
  
  METHODS
  We conducted a search in PubMed, EMBASE, The Cochrane Library, and Web of Science for randomized controlled trials (RCTs) and non-RCTs comparing PWB and early FWB after uncemented THA. Two authors conducted the selection of studies, data extraction, and assessment of risk of bias independently. A pooled meta-analysis was performed using the RevMan 5.3 software.
  
  
  RESULTS
  Six RCTs and three non-RCTs met the inclusion criteria. The meta-analysis indicated that compared with PWB, the FWB group showed greater femoral subsidence at 3-month follow-up (MD = -0.12, 95% CI -0.22 to -0.01, P = 0.03). There were no significant differences in the hip Harris score at 1-year and 2-year follow-up (MD = 1.54, 95% CI -0.83 to 3.90, P = 0.20; MD = 0.08, 95% CI -1.19 to 1.34, P = 0.90, respectively), in femoral subsidence at 2-year follow-up and at two additional years of follow-up (MD = -0.03, 95% CI -0.31 to 0.25, P = 0.84; (MD = -0.02, 95% CI -0.37 to 0.33, P = 0.91, respectively). There were no significant differences in the incidences of bone ingrowth fixation, spot welds, and radiolucent lines.
  
  
  CONCLUSIONS
  This meta-analysis shows that early FWB in patients with uncemented THA could be safe and could not increase the incidence of postoperative complications.
authors.affiliation: Department of Orthopedics, Tianjin Hospital, No. 406, Jiefang Nan Road, Tianjin, 300211, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Tian
authors.affiliation: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: Department of Orthopedics, Tianjin Hospital, No. 406, Jiefang Nan Road, Tianjin, 300211, People's Republic of China.
authors.forename: Gui-Jun
authors.initials: GJ
authors.lastname: Xu
authors.affiliation: Department of Orthopedics, Tianjin Hospital, No. 406, Jiefang Nan Road, Tianjin, 300211, People's Republic of China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Sun
authors.affiliation: Department of Orthopedics, Tianjin Hospital, No. 406, Jiefang Nan Road, Tianjin, 300211, People's Republic of China. 2008021123@tijmu.edu.cn.
authors.forename: Xin-Long
authors.initials: XL
authors.lastname: Ma
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000639:trends*; D006801:Humans; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology*; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D016474:Weight-Bearing / Q000502:physiology*
keywords: Arthroplasty; Hip; Meta-analysis; Uncemented; Weight bearing