title: miRNA-21 as a novel therapeutic target in lung cancer.
abstract: Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for the high mortality rate. microRNAs (miRNAs) are key players in gene regulation and therefore in tumorigenesis. As far as lung carcinogenesis is concerned, miRNAs open novel fields in biomarker research, in diagnosis, and in therapy. In this review we focus on miR-21 in lung cancer and especially on how miR-21 is involved 1) as a biomarker in response or resistance to therapy or 2) as a therapeutic target.
authors.affiliation: Analysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece.
authors.forename: Athina
authors.initials: A
authors.lastname: Markou
authors.affiliation: Analysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece.
authors.forename: Martha
authors.initials: M
authors.lastname: Zavridou
authors.affiliation: Analysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece.
authors.forename: Evi S
authors.initials: ES
authors.lastname: Lianidou
keywords: NSCLC; lung cancer; miR-21; response to therapy; therapeutic target