title: Biocompatibility of NiTi alloys in the cell behaviour.
abstract: Metallic biomaterial alloys composed of nickel and titanium have unique thermal shape memory, superelastic, and high damping properties, which are widely used in the medicine. The major parameter evaluated in the studies regarding the behaviour of the material in the contact with organism or cells is biocompatibility. The aim of the studies is to clarify the differences in the proliferation, growth, and morphology especially in the cell cultures. The cytotoxicity is affected among other by release of the metal ions in the presence of the metal alloy, which is further dependent on the possible treatments of the material and the corrosive properties. To evaluate the cytotoxicity, wide range of tests including the Sulforhodamine B assay and MTT tests, expression profiles, cell survival tests such as apoptotic test are used. The review compares the cell behaviour in contact with the material alloys composed of nickel and titanium with respect to different materials composition and different surface treatment that affects the ion release. Even though the results published so far are controversial, almost all data suggest sufficient biocompatibility in medical use.
authors.affiliation: Institute of Pathological Physiology, Medical Faculty, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Sevcikova
authors.affiliation: Institute of Pathological Physiology, Medical Faculty, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. goldberg@med.muni.cz.
authors.forename: Monika
authors.initials: M
authors.lastname: Pavkova Goldbergova
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012235:Rhodamines / Q000737:chemistry; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D012235:Rhodamines; C040654:titanium nickelide; C022027:lissamine rhodamine B; D009532:Nickel; D014025:Titanium
keywords: Alloy; Biocompatibility; Biomaterial; Cell; NiTi