title: Vascular lesions in patient with Takayasu arteritis and massive elevated lipoprotein(a) levels. Residual involvement or premature aterosclerosis?
abstract: Lipoprotein (a) [Lp(a)] is a lipoprotein defined by presenting a specific apolipoprotein, ApoA, linked to the ApoB-100 by different types of chemical bonds, including a disulfide bridge. Despite their atherogenic mechanism is not fully understood, its importance has been demonstrated in the development of premature aterosclerosis. Multiple studies have shown its role as a cardiovascular risk factor associated with heart disease and stroke. We report the case of a patient with a diagnosis of Takayasu arteritis in which a massive elevation of Lp(a) was detected. We emphasize its diagnostic and therapeutic implications.
authors.affiliation: Unidad de Colagenosis y Enfermedades Minoritarias, Unidad Experimental de Riesgo Cardiovascular, Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: jc.alarc88@gmail.com.
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Alarcón García
authors.affiliation: Unidad de Colagenosis y Enfermedades Minoritarias, Unidad Experimental de Riesgo Cardiovascular, Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Santiago
authors.initials: S
authors.lastname: Rodríguez Suárez
authors.affiliation: Unidad de Colagenosis y Enfermedades Minoritarias, Unidad Experimental de Riesgo Cardiovascular, Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Ovidio
authors.initials: O
authors.lastname: Muñiz Grijalvo
authors.affiliation: Unidad de Colagenosis y Enfermedades Minoritarias, Unidad Experimental de Riesgo Cardiovascular, Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: Salvador
authors.initials: S
authors.lastname: García Morillo
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D002318:Cardiovascular Diseases / Q000209:etiology; D000072226:Computed Tomography Angiography; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D012307:Risk Factors; D013625:Takayasu Arteritis / Q000097:blood / Q000175:diagnosis / Q000473:pathology*
chemical_list: D017270:Lipoprotein(a)
keywords: Ateroesclerosis prematura; Diagnóstico de Takayasu; Lipoprotein; Lipoprotein levels; Lipoproteína; Niveles de lipoproteína; Premature atherosclerosis; Takayasu and ateroesclerosis; Takayasu diagnosis; Takayasu y ateroesclerosis