title: Zebrafish models in neuropsychopharmacology and CNS drug discovery.
abstract: Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.
authors.affiliation: Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.
authors.forename: Kanza M
authors.initials: KM
authors.lastname: Khan
authors.affiliation: Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.|The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Collier
authors.affiliation: The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.|Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
authors.forename: Darya A
authors.initials: DA
authors.lastname: Meshalkina
authors.affiliation: Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
authors.forename: Elana V
authors.initials: EV
authors.lastname: Kysil
authors.affiliation: Ural Federal University, Ekaterinburg, Russia.
authors.forename: Sergey L
authors.identifier: 0000-0001-5921-6680
authors.initials: SL
authors.lastname: Khatsko
authors.affiliation: Ural Federal University, Ekaterinburg, Russia.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Kolesnikova
authors.affiliation: Ural Federal University, Ekaterinburg, Russia.
authors.forename: Yury Yu
authors.identifier: 0000-0002-1333-6676
authors.initials: YY
authors.lastname: Morzherin
authors.affiliation: The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.|Department of Behavioral Sciences, Arkansas Tech University, Russellville, AR, USA.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Warnick
authors.affiliation: The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.|Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.|Ural Federal University, Ekaterinburg, Russia.|Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China.
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
authors.affiliation: Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.|The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Echevarria
mesh_terms: D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D004195:Disease Models, Animal; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D015027:Zebrafish
chemical_list: D002491:Central Nervous System Agents; D054852:Small Molecule Libraries