title: [Lipid-lowering effect of seven traditional Chinese medicine monomers in zebrafish system].
abstract: The present study aimed to study lipid-lowering effect of seven traditional Chinese medicine monomers in zebrafish system. Zebrafish were fed with high fat diet to establish a hyperlipemia model, then fasted and bathed with seven traditional Chinese medicine monomers stigmasterol, triacontanol, chrysophanol, vanillic acid, shikimic acid, polydatin and oleanolic acid respectively. The oil red O staining was used to detect the blood lipids of zebrafish. Serum total cholesterol and triglyceride levels were detected to validate the lipid-lowering effect. The result showed that a zebrafish model of hyperlipemia could be established by feeding larvae zebrafish with high fat diet. Among the seven traditional Chinese medicine monomers, chrysophanol had lipid-lowering effect. Chrysophanol significantly reduced serum total cholesterol and triglyceride levels in adult zebrafish fed with high fat diet. Chrysophanol accelerated peristalsis frequency of zebrafish intestine and the excretion of high fat food. It is concluded that chrysophanol has lipid- lowering effect in zebrafish, and the mechanism of the effect may be due to the roles of chrysophanol in reducing lipid absorption from gastrointestinal tract and accelerating the excretion of food.
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. wcqian@hotmail.com.
authors.forename: Chang-Qian
authors.initials: CQ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Fan
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Han
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Hua-Su
authors.initials: HS
authors.lastname: Zeng
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology; D059305:Diet, High-Fat; D005233:Fatty Alcohols / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007814:Larva; D008055:Lipids / Q000097:blood; D008516:Medicine, Chinese Traditional; D009828:Oleanolic Acid / Q000494:pharmacology; D012765:Shikimic Acid / Q000494:pharmacology; D013265:Stigmasterol / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology; D014641:Vanillic Acid / Q000494:pharmacology; D015027:Zebrafish
chemical_list: D000880:Anthraquinones; D005233:Fatty Alcohols; D005960:Glucosides; D000960:Hypolipidemic Agents; D008055:Lipids; D013267:Stilbenes; D012765:Shikimic Acid; D009828:Oleanolic Acid; C047578:1-triacontanol; D013265:Stigmasterol; D014641:Vanillic Acid; C027113:chrysophanic acid; C058229:polydatin