title: The effectiveness of intravenous vitamin K in correcting cirrhosis-associated coagulopathy.
abstract: OBJECTIVE
  The goal of this study was to evaluate the effectiveness of intravenous (IV) vitamin K in cirrhosis.
  
  
  METHODS
  This was a retrospective study of cirrhotic patients, not on anticoagulation, with administration of IV vitamin K and a baseline INR > 1.5. The primary outcome was the effectiveness of therapy defined by a 30% decrease in INR or a reduction in INR to an absolute value of ≤1.5.
  
  
  RESULTS
  A total of 96 patients were included in the cohort. There was an average decrease in INR of 0.31; however, 60 patients (62.3%) failed to achieve at least a 10% decrease. Sixteen patients (16.7%) met the primary effectiveness endpoint.
  
  
  CONCLUSIONS
  The use of IV vitamin K to correct coagulopathy of cirrhosis may not be beneficial.
authors.affiliation: Department of Pharmacy, UPMC Presbyterian Hospital, Pittsburgh, PA, USA.
authors.forename: Ryan M
authors.identifier: http://orcid.org/0000-0002-0631-1358
authors.initials: RM
authors.lastname: Rivosecchi
authors.affiliation: School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Kane-Gill
authors.affiliation: West Virginia University Hospitals, Morgantown, WV, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Garavaglia
authors.affiliation: Virginia Commonwealth University Medical Center, Richmond, VA, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: MacLasco
authors.affiliation: School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Johnson
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014812:Vitamin K / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; D014812:Vitamin K
keywords: cirrhosis; coagulopathy; liver failure; phytonadione; vitamin K