title: Combination ofNigella sativaand Honey in Eradication of GastricHelicobacter pyloriInfection.
abstract: BACKGROUND
  GastricHelicobacter pyloriis extremely common worldwide.
  
  
  OBJECTIVE
  The aim of this study was to assess the effectiveness of combination ofNigella sativaand honey (Dosin) in eradication of gastricH. pyloriinfection.
  
  
  METHODS
  Nineteen patients who had positive result forH. pyloriinfection by urea breath test (UBT) without a past history of peptic ulcer, gastric cancer or gastrointestinal bleeding, were suggested to receive one teaspoon of the mixture of Dosin (6 g/day ofN. sativaas ground seeds and 12 g/day of honey) three times a day after meals for two weeks. The second UBT was used to detect the presence ofH. pylorifour weeks after completion of the test. In addition, symptoms of dyspepsia were scored before and after the study and analyzed with Wilcoxon signed-rank test.
  
  
  RESULTS
  Fourteen patients completed the study. Negative UBT was observed in 57.1% (8/14) of participants after intervention. The median and interquartile range (IQR) of total dyspepsia symptoms was significantly reduced from 5.5 (5 - 12) to 1 (0 - 4) (P = 0.005). All the patients tolerated Dosin except for one who was excluded due to mild diarrhea. No serious adverse events were reported.
  
  
  CONCLUSIONS
  Dosin was concluded to be an antiH. pyloriand an anti-dyspeptic agent. Further studies are recommended to investigate the effect of Dosin plus antibiotics (concurrently or following another) on gastricH. pyloriinfection.
authors.affiliation: Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Fataneh
authors.initials: F
authors.lastname: Hashem-Dabaghian
authors.affiliation: Department of Gastroenterology, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Shahram
authors.initials: S
authors.lastname: Agah
authors.affiliation: Research Institute for Islamic and Complementary Medicine, School of Iranian Traditional Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Taghavi-Shirazi
authors.affiliation: Research Institute for Islamic and Complementary Medicine, School of Iranian Traditional Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ghobadi
keywords: Helicobacter pylori; Honey; Medicine; Nigella sativa; Phytotherapy; Traditional