title: Novel Biomarkers for Pancreatic Cysts.
abstract: With increased utilization and ongoing advancements in cross-sectional abdominal imaging, the identification of a pancreatic cyst has become a frequent finding. While many pancreatic cysts are associated with a benign clinical course, others may transform into pancreatic ductal adenocarcinoma. However, distinguishing a benign from a malignant pancreatic cyst or pancreatic cyst with malignant potential on the basis of standard clinical findings, imaging parameters and ancillary studies can be challenging. Hence, a significant interest within the past decade has been the identification of novel biomarkers to accurately classify and prognosticate a pancreatic cyst. Within this review, we discuss novel DNA, miRNA, protein and metabolite biomarkers, and their relevance in clinical practice. In addition, we focus on future areas of research that have the potential to change pancreatic cyst management.
authors.affiliation: Department of Medicine, University of Pittsburgh Medical Center, UPMC Presbyterian Hospital, 200 Lothrop Street, M2, C-wing, Pittsburgh, PA, 15213, USA.
authors.forename: Harkirat
authors.initials: H
authors.lastname: Singh
authors.affiliation: Department of Medicine, University of Pittsburgh Medical Center, UPMC Presbyterian Hospital, 200 Lothrop Street, M2, C-wing, Pittsburgh, PA, 15213, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: McGrath
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, UPMC Presbyterian Hospital, 200 Lothrop Street, Room A616.2, Pittsburgh, PA, 15213, USA. singhiad@upmc.edu.
authors.forename: Aatur D
authors.initials: AD
authors.lastname: Singhi
mesh_terms: D015415:Biomarkers; D004247:DNA / Q000097:blood* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000378:metabolism; D010181:Pancreatic Cyst / Q000097:blood* / Q000175:diagnosis*; D011506:Proteins / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D011506:Proteins; D004247:DNA
keywords: Intraductal papillary mucinous neoplasm; Mucinous cystic neoplasm; Pancreatic cancer; Serous cystadenoma