title: Amplified electrochemical sensor employing CuO/SWCNTs and 1-butyl-3-methylimidazolium hexafluorophosphate for selective analysis of sulfisoxazole in the presence of folic acid.
abstract: In the present work, CuO nanoparticle decorated on single wall carbon nanotubes (CuO/SWCNTs) nanocomposite was successfully synthesized by chemical precipitation method and used for modification of carbon paste electrode (CPE) in the presence of 1-butyl-3-methylimidazolium hexafluorophosphate (1-B-3-MIHFP) liquid as binder. The novel voltammetric sensor was used as first electrochemical sensor for determination of sulfisoxazole (SFX). CuO/SWCNTs nanocomposite characterized by scanning electron microscopy (SEM) and X-ray powder diffraction (XRD) methods. Voltammetric methods such as cyclic voltammetry, square wave voltammetry (SWV), electrochemical impedance spectroscopy (EIS) and chronoamperometry were performed to assess the electrochemical performance of CuO/SWCNTs/1-B-3-MIHFP/CPE towards SFX in aqueous solution. The voltammetric obtained data confirm the significant enhancement of oxidation current and reduction overvoltage for electro-oxidation of SFX at a surface of CuO/SWCNTs/1-B-3-MIHFP/CPE. The square wave voltammetric response shows the linear increment of oxidation signals with an increase in the concentration of SFX in the range of 0.08-650μM with limit of detection 0.04μM. Using CuO/SWCNTs/1-B-3-MIHFP/CPE the SFX and folic acid peaks are separated ca. 0.72 and 0.895V, respectively; hence SFX can be detected in the presence of folic acid. Finally, the CuO/SWCNTs/1-B-3-MIHFP/CPE was used as high sensitive tools for analysis of SFX and folic acid in real samples.
authors.affiliation: Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran. Electronic address: h.karimi.maleh@gmail.com.
authors.forename: Hassan
authors.initials: H
authors.lastname: Karimi-Maleh
authors.affiliation: Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P.O. Box 87317-51167, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Amini
authors.affiliation: Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P.O. Box 87317-51167, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Akbari
authors.affiliation: Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran.
authors.forename: Moein
authors.initials: M
authors.lastname: Shojaei
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D015374:Biosensing Techniques; D003300:Copper / Q000737:chemistry*; D058266:Dielectric Spectroscopy; D055664:Electrochemical Techniques; D004566:Electrodes; D005492:Folic Acid / Q000032:analysis*; D007093:Imidazoles / Q000737:chemistry*; D057230:Limit of Detection; D053761:Nanocomposites / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D013444:Sulfisoxazole / Q000032:analysis*; D014961:X-Ray Diffraction
chemical_list: C412621:1-butyl-3-methylimidazolium hexafluorophosphate; D000900:Anti-Bacterial Agents; D007093:Imidazoles; D037742:Nanotubes, Carbon; D013444:Sulfisoxazole; D003300:Copper; D005492:Folic Acid; C030973:cupric oxide
keywords: 1-Butyl-3-methylimidazolium hexafluorophosphate; CuO/SWCNTs nanocomposite; Electrochemical sensor; Folic acid