title: Three-dimensional parametric modeling of bicuspid aortopathy and comparison with computational flow predictions.
abstract: Bicuspid aortic valve (BAV)-associated ascending aneurysmal aortopathy (namely "bicuspid aortopathy") is a heterogeneous disease making surgeon predictions particularly challenging. Computational flow analysis can be used to evaluate the BAV-related hemodynamic disturbances, which likely lead to aneurysm enlargement and progression. However, the anatomic reconstruction process is time consuming so that predicting hemodynamic and structural evolution by computational modeling is unfeasible in routine clinical practice. The aim of the study was to design and develop a parametric program for three-dimensional (3D) representations of aneurysmal aorta and different BAV phenotypes starting from several measures derived by computed-tomography angiography (CTA). Assuming that wall shear stress (WSS) has an important implication on bicuspid aortopathy, computational flow analyses were then performed to estimate how different would such an important parameter be, if a parametric aortic geometry was used as compared to standard geometric reconstructions obtained by CTA scans. Morphologic parameters here documented can be used to rapidly model the aorta and any phenotypes of BAV. t-test and Bland-Altman plot demonstrated that WSS obtained by flow analysis of parametric aortic geometries was in good agreement with that obtained from the flow analysis of CTA-related geometries. The proposed program offers a rapid and automated tool for 3D anatomic representations of bicuspid aortopathy with promising application in routine clinical practice by reducing the amount of time for anatomic reconstructions.
authors.affiliation: Fondazione Ri.MED.|Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pasta
authors.affiliation: Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gentile
authors.affiliation: Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT.
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Raffa
authors.affiliation: Dipartimento dell'Innovazione Industriale e Digitale (DIID), Universita di Palermo, Palermo, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Scardulla
authors.affiliation: Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT.
authors.forename: Diego
authors.initials: D
authors.lastname: Bellavia
authors.affiliation: Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT.
authors.forename: Angelo
authors.initials: A
authors.lastname: Luca
authors.affiliation: Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT.
authors.forename: Michele
authors.initials: M
authors.lastname: Pilato
authors.affiliation: Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT.
authors.forename: Cesare
authors.initials: C
authors.lastname: Scardulla
mesh_terms: D000368:Aged; D001011:Aorta / Q000002:abnormalities / Q000000981:diagnostic imaging*; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging* / Q000209:etiology; D001021:Aortic Valve / Q000002:abnormalities* / Q000000981:diagnostic imaging; D000082882:Bicuspid Aortic Valve Disease; D019295:Computational Biology; D000072226:Computed Tomography Angiography / Q000379:methods; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging*; D006439:Hemodynamics; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D011446:Prospective Studies; D012189:Retrospective Studies; D012984:Software; D013314:Stress, Mechanical
keywords: -Aortic failure; -Ascending thoracic aortic aneurysm; -Finite-element analysis; -Three-dimensional anatomic reconstruction; Bicuspid aortic valve