title: Gaseous Air Pollution and the Risk for Stroke Admissions: A Case-Crossover Study in Beijing, China.
abstract: Background:Though increasing evidence supports association between gaseous air pollution and stroke, it remains unclear whether the effects differ in season, sex and age. The aim of this study was to examine the associations of gaseous air pollution with stroke admissions in Beijing, 2013-2014 in different subgroups.Methods:Case-crossover design and conditional logistic regression were used to perform the analyses. We examined the exposure-response relationship between air pollution and stroke. Stratified analyses were performed in different seasons, sex, and age groups.Results:There were 147,624 stroke admissions during the study period. In the whole study period, percent changes of stroke admissions were 0.82% (95% CI: 0.52% to 1.13%) and 0.73% (95% CI: 0.44% to 1.03%) per 10 μg/m³ increase in the same day conentration of nitrogen dioxide (NO₂) and sulfur dioxide (SO₂). The positive associations were higher in warm seasons and with patients >65 years (p< 0.05). Contrary effects of carbon monoxide (CO) and ozone on stroke admissions were observed in different seasons.Conclusions:NO₂ and SO₂ were positively associated with stroke admissions, with stronger effects in warm seasons and with patients >65 years. The associations of CO and ozone with stroke admissions differed across seasons.
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China. hff87hff87@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China. hff87hff87@163.com.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Huang
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China. lyx100@ccmu.edu.cn.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China. lyx100@ccmu.edu.cn.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Beijing Public Health Information Center, Beijing 100050, China. tanpeng@bjhb.gov.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Tan
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China. xuqinhuachong@126.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China. xuqinhuachong@126.com.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China. taolixin.2008@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China. taolixin.2008@163.com.
authors.forename: Lixin
authors.initials: L
authors.lastname: Tao
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China. guojin5827501@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China. guojin5827501@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Guo
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China. zhangfeng@ccmu.edu.cn.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China. zhangfeng@ccmu.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Beijing Public Health Information Center, Beijing 100050, China. xiexq@bjhb.gov.cn.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Xie
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China. statguo@ccmu.edu.cn.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China. statguo@ccmu.edu.cn.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Guo
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis*; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis*; D000068476:Beijing; D002248:Carbon Monoxide / Q000032:analysis; D002681:China; D018592:Cross-Over Studies; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000032:analysis; D010126:Ozone / Q000032:analysis; D012621:Seasons; D012737:Sex Factors; D020521:Stroke / Q000139:chemically induced*; D013458:Sulfur Dioxide / Q000032:analysis
chemical_list: D000393:Air Pollutants; D013458:Sulfur Dioxide; D010126:Ozone; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide
keywords: air pollution; exposure-response relationship; hospital admission; stroke