title: Regional cerebral blood flow assessed by single photon emission computed tomography (SPECT) in dogs with congenital portosystemic shunt and hepatic encephalopathy.
abstract: Regional cerebral blood flow (rCBF) in eight dogs with congenital portosystemic shunt (PSS) and hepatic encephalopathy (HE) was compared with rCBF in eight healthy control dogs using single photon emission computed tomography (SPECT) with a99mtechnetium-hexamethylpropylene amine oxime (99mTc-HMPAO) tracer. SPECT scans were abnormal in all PSS dogs. Compared to the control group, rCBF in PSS dogs was significantly decreased in the temporal lobes and increased in the subcortical (thalamic and striatal) area. Brain perfusion imaging alterations observed in the dogs with PSS and HE are similar to those in human patients with HE. These findings suggest that dogs with HE and PSS have altered perfusion of mainly the subcortical and the temporal regions of the brain.
authors.affiliation: Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Electronic address: matan.or@ugent.be.
authors.forename: Matan
authors.initials: M
authors.lastname: Or
authors.affiliation: Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Kathelijne
authors.initials: K
authors.lastname: Peremans
authors.affiliation: Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Valentine
authors.initials: V
authors.lastname: Martlé
authors.affiliation: Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Vandermeulen
authors.affiliation: Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: Bosmans
authors.affiliation: Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Nausikaa
authors.initials: N
authors.lastname: Devriendt
authors.affiliation: Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: Hilde
authors.initials: H
authors.lastname: de Rooster
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs / Q000002:abnormalities*; D005260:Female; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000662:veterinary*; D008297:Male; D011169:Portal Vein / Q000002:abnormalities*; D015899:Tomography, Emission-Computed, Single-Photon / Q000662:veterinary; D054079:Vascular Malformations
keywords: (99m)Technetium-hexamethylpropylene amine oxime; Canine; Hepatic encephalopathy; Portosystemic shunt; Single photon emission computed tomography