title: [Circular RNA in human disease and their potential clinic significance].
abstract: Circular RNAs (circ RNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. They share a stable structure, high expression and often exhibit tissue/developmental-stage-specific expression. Emerging evidence indicates that circRNAs might play important roles in human disease, such as cancer, neurological disorders and atherosclerotic vascular disease risk. The huge potentials of circRNAs are recently being discovered from the laboratory to the clinic. CircRNAs might be developed as a potential novel and stable biomarker and potential drugs used in disease diagnosis and treatment. Here, we review the current understanding of the roles of circRNAs in human disease and their potential clinic significance in disease.
authors.affiliation: Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. xbliu@medmail.com.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Chunlu
authors.initials: C
authors.lastname: Tan
authors.forename: Gang
authors.initials: G
authors.lastname: Mai
authors.forename: Xubao
authors.initials: X
authors.lastname: Liu
mesh_terms: D015415:Biomarkers / Q000032:analysis; D004194:Disease / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D012313:RNA / Q000235:genetics*; D020871:RNA Stability; D000079962:RNA, Circular; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D015415:Biomarkers; D000079962:RNA, Circular; D012313:RNA