title: An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation.
abstract: Novel 2-thiazolylphthalazine derivatives were efficiently synthesized under ultrasound irradiation, resulting in high yields and short reaction times after optimization of the reaction conditions. All prepared compounds were fully characterized using spectroscopic methods. They were screened for their antimicrobial activity against Gram-positive and Gram-negative bacteria as well as for antifungal activity. The antimicrobial activity profile of the tested compounds showed some promising results. The potent activity of compounds4d,7b(117% zone inhibition) and7c(105% zone inhibition) againstSalmonella sp., exceeding that of the reference drugGentamycinis particularly noteworthy. In general, the newly synthesized thiazolylphthalazine derivatives showed higher antimicrobial activity against the tested Gram-negative bacteria than against Gram-positive bacteria and fungi.
authors.affiliation: Department of Chemistry of Natural and Microbial Products, National Research Center, Dokki 12622, Egypt. elsharabasy2000@gmail.com.|Collage of Science and Humanities, Sattam bin Abdul Aziz University, Alkharj City 11942, Saudi Arabia. elsharabasy2000@gmail.com.
authors.forename: Fatma S
authors.initials: FS
authors.lastname: Elsharabasy
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. s.m.gomha@gmail.com.
authors.forename: Sobhi M
authors.initials: SM
authors.lastname: Gomha
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. thoraya-f@hotmail.com.|Department of Chemistry, Faculty of Applied Science, UmmAl-Qura University, Makkah Almukkarramah 21514, Saudi Arabia. thoraya-f@hotmail.com.
authors.forename: Thoraya A
authors.initials: TA
authors.lastname: Farghaly
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), AlAzhar University, Cairo1 1754, Egypt. helzahabi@yahoo.com.
authors.forename: Heba S A
authors.initials: HS
authors.lastname: Elzahabi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D015394:Molecular Structure; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry; D000069453:Ultrasonic Waves
chemical_list: D000890:Anti-Infective Agents; D010793:Phthalazines; D013844:Thiazoles
keywords: antimicrobial activity; hydrazonoyl chlorides; thiazolylphthalazinediones; ultrasound irradiation