title: Universal CAR T Cells Treat Leukemia.
abstract: Two infants with relapsed, refractory B-cell acute lymphoblastic leukemia went into complete remission after being treated with CD19-targeting CAR T cells derived from an unmatched donor. The study is the first to demonstrate that a universal form of CAR T-cell therapy can be safely utilized.
mesh_terms: D018941:Antigens, CD19 / Q000235:genetics / Q000276:immunology*; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D007167:Immunotherapy; D007223:Infant; D015448:Leukemia, B-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015514:Oncogene Proteins, Fusion / Q000276:immunology / Q000627:therapeutic use; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000627:therapeutic use*; D012074:Remission Induction; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D018941:Antigens, CD19; C000604811:CD19 molecule, human; D015514:Oncogene Proteins, Fusion; D011948:Receptors, Antigen, T-Cell