title: Role of systemic injection of rabies immunoglobulin in rabies vaccination.
abstract: To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably to passive or adaptive immunization, suggesting that the main function of RIG in individuals with category III exposure is to neutralize rabies virus via immediate local infiltration of the wound.
authors.affiliation: School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, People's Republic of China.|Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
authors.forename: Weichen
authors.initials: W
authors.lastname: Wu
authors.affiliation: Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
authors.forename: Shuqing
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yu
authors.affiliation: Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Tao
authors.affiliation: Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
authors.forename: Xuexin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Yan
authors.affiliation: Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, People's Republic of China.
authors.forename: Zongshen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China. zhuwuyang1971@sohu.com.
authors.forename: Wuyang
authors.initials: W
authors.lastname: Zhu
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage* / Q000276:immunology; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011818:Rabies / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology; D011820:Rabies virus / Q000276:immunology* / Q000502:physiology; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D011819:Rabies Vaccines