title: Efficacy and Safety of 2% Topical Propranolol Cream for the Treatment of Proliferating Infantile Strawberry Hemangiomas.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of 2% topical propranolol cream in the treatment of proliferating infantile strawberry hemangiomas.
  
  
  METHODS
  A total of 40 infants were enrolled; 2% propranolol cream was applied three times daily. In the subsequent monthly visit, dynamic changes in tumor size, texture, and color were recorded. The adverse events (AEs) were observed. Treatment outcomes were scored on a four-point scale. All patients were followed up for 12 mo after treatment.
  
  
  RESULTS
  The overall response was graded Scale 1 (poor response) in 2 patients, Scale 2 (moderate response) in 15 patients, Scale 3 (good response) in 17 patients, and Scale 4 (excellent response) in 6 patients. No significant differences were seen in treatment outcomes between female and male patients, among lesion locations/size, or in the age at the start of the treatment. No obvious AEs were reported.
  
  
  CONCLUSIONS
  2% topical propranolol cream is safe and effective for the treatment of proliferating infantile strawberry hemangiomas.
authors.affiliation: Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China.
authors.forename: Xingcun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China.
authors.forename: Junbo
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China.
authors.forename: Yunchuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China. 11794643@qq.com.
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000279:Administration, Cutaneous; D005260:Female; D006392:Hemangioma, Cavernous / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D011433:Propranolol
keywords: Efficacy; Infant; Safety; Strawberry hemangiomas; Topical propranolol; β-adrenergic receptor blocker