title: Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction.
abstract: The potential role of intestinal microbiota in the etiology of various human diseases has attracted massive attention in the last decade. As such, the intestinal microbiota has been advanced as an important contributor in the development of obesity and obesity-related metabolic dysfunctions, amongst others. Experiments in animal models have produced evidence for a causal role of intestinal microbiota in the etiology of obesity and insulin resistance. However, with a few exceptions, such causal relation is lacking for humans and most publications merely report associations between intestinal microbial composition and metabolic disorders such as obesity and type 2 diabetes. Thus, the reciprocal relationship between the bacteria and these metabolic disorders remains a matter of debate. The main objective of this review is to critically assess the driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes.
authors.affiliation: Department of Vascular Medicine, Academic Medical Center (AMC), University of Amsterdam, The Netherlands.
authors.forename: Kristien E
authors.initials: KE
authors.lastname: Bouter
authors.affiliation: Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands; Institute for Cardiovascular Research (ICaR), VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Daniël H
authors.initials: DH
authors.lastname: van Raalte
authors.affiliation: Department of Vascular Medicine, Academic Medical Center (AMC), University of Amsterdam, The Netherlands; Department of Pediatrics, Laboratory of Metabolic Diseases, University of Groningen, UMCG, Groningen, The Netherlands.
authors.forename: Albert K
authors.initials: AK
authors.lastname: Groen
authors.affiliation: Department of Vascular Medicine, Academic Medical Center (AMC), University of Amsterdam, The Netherlands; Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands; Institute for Cardiovascular Research (ICaR), VU University Medical Center, Amsterdam, The Netherlands; Wallenberg Laboratory, University of Gothenberg, Gothenberg, Sweden. Electronic address: m.nieuwdorp@amc.uva.nl.
authors.forename: Max
authors.initials: M
authors.lastname: Nieuwdorp
mesh_terms: D000818:Animals; D018988:Bacterial Translocation; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control / Q000628:therapy*; D004032:Diet; D000069467:Fecal Microbiota Transplantation; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D009765:Obesity / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy*
keywords: Diabetes; Fecal Transplantation; Gut Microbiota; Obesity