title: MechanoAPI-ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis.
abstract: An alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI-ILs) is reported. Six new API-ILs based on gabapentin and l-glutamic acid were successfully synthesized and characterized, demonstrating that mechanochemistry is a very promising synthetic strategy. Results compare both the new and the classical approach and clearly show the advantages of the new method. This new technique is faster, solvent free, reproducible, selective, and leads to higher yields.
authors.affiliation: CQE-Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001, Lisboa, Portugal.
authors.forename: Inês C B
authors.identifier: 0000-0002-1639-7554
authors.initials: IC
authors.lastname: Martins
authors.affiliation: CQE-Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001, Lisboa, Portugal.
authors.forename: M Conceição
authors.identifier: 0000-0002-3068-4920
authors.initials: MC
authors.lastname: Oliveira
authors.affiliation: CQE-Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001, Lisboa, Portugal.
authors.forename: Hermínio P
authors.identifier: 0000-0002-0808-1306
authors.initials: HP
authors.lastname: Diogo
authors.affiliation: REQUIMTE-LAQV-Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, 2829-516, Portugal.
authors.forename: Luís C
authors.identifier: 0000-0003-2520-1151
authors.initials: LC
authors.lastname: Branco
authors.affiliation: CQE-Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001, Lisboa, Portugal.
authors.forename: M Teresa
authors.identifier: 0000-0003-0994-1352
authors.initials: MT
authors.lastname: Duarte
mesh_terms: D000588:Amines / Q000138:chemical synthesis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003509:Cyclohexanecarboxylic Acids / Q000138:chemical synthesis; D000077206:Gabapentin; D018698:Glutamic Acid / Q000138:chemical synthesis; D055772:Green Chemistry Technology / Q000379:methods*; D052578:Ionic Liquids / Q000737:chemistry*; D055595:Mechanical Phenomena; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D052578:Ionic Liquids; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
keywords: gabapentin; ionic liquids; l-glutamic acid; mechanochemistry; pharmaceutical