title: PARP1 and Sox2: An Unlikely Team of Pioneers to Conquer the Nucleosome.
abstract: In this issue of Molecular Cell, Liu and Kraus (2017) demonstrate that the pioneer transcription factor Sox2 requires PARP1 to bind to a subset of its recognition motifs, which are located within nucleosomes across the genome.
authors.affiliation: Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, CO 80309, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Gaullier
authors.affiliation: Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, CO 80309, USA. Electronic address: karolin.luger@colorado.edu.
authors.forename: Karolin
authors.initials: K
authors.lastname: Luger
mesh_terms: D016678:Genome; D009707:Nucleosomes; D055748:SOXB1 Transcription Factors / Q000235:genetics*
chemical_list: D009707:Nucleosomes; D055748:SOXB1 Transcription Factors
keywords: ChIP-seq; MNase-seq; PARP1; RNA-seq; Sox2; biochemistry; chromatin; nucleosome; pioneer transcription factor