title: Splicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs.
abstract: The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number ofcis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of HPV16cis-acting RNA elements and cellular and viraltrans-acting factors that regulate HPV16 gene expression at the level of splicing and polyadenylation.
authors.affiliation: Department of Laboratory Medicine, Lund university, 223 62 Lund, Sweden. troy_chengjun.wu@med.lu.se.
authors.forename: Chengjun
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Laboratory Medicine, Lund university, 223 62 Lund, Sweden. naoko.kajitani@med.lu.se.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kajitani
authors.affiliation: Department of Laboratory Medicine, Lund university, 223 62 Lund, Sweden. stefan.schwartz@med.lu.se.
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwartz
mesh_terms: D044127:Epigenesis, Genetic; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000378:metabolism; D052162:Human papillomavirus 16 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D030361:Papillomavirus Infections / Q000821:virology*; D026723:Polyadenylation; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012333:RNA, Messenger; D014764:Viral Proteins
keywords: HPV16; SR-protein; hnRNP; human papillomavirus; polyadenylation; splicing