title: Diaporthe soft tissue infection in a heart transplant patient.
abstract: Infections caused by Diaporthe species are very uncommon. We describe a heart transplant recipient 14 years post transplant who developed a soft tissue fungal infection due to a Diaporthe species that responded well to surgical excision and posaconazole therapy. The Aspergillus galactomannan index was markedly elevated, and returned to normal following treatment. Solid organ transplant patients remain at risk of infection long after transplantation and should be counseled about risk avoidance.
authors.affiliation: Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Rakita
authors.affiliation: Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: O'Brien
authors.affiliation: Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Lori
authors.initials: L
authors.lastname: Bourassa
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D001203:Ascomycota / Q000302:isolation & purification / Q000472:pathogenicity*; D004271:DNA, Fungal / Q000302:isolation & purification; D006020:Glycopeptides / Q000302:isolation & purification; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects* / Q000379:methods; D008297:Male; D009181:Mycoses / Q000097:blood / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000628:therapy; D017202:Myocardial Ischemia / Q000601:surgery*; D016133:Polymerase Chain Reaction; D018461:Soft Tissue Infections / Q000097:blood / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000628:therapy; D013848:Thigh / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D006020:Glycopeptides; D014230:Triazoles; C018949:galactomannane peptide; C101425:posaconazole
keywords: 
  Diaporthe
  ; Aspergillus galactomannan; antifungal therapy; fungal infection