title: Alterations in Cortical Thickness and White Matter Integrity in Mild-to-Moderate Communicating Hydrocephalic School-Aged Children Measured by Whole-Brain Cortical Thickness Mapping and DTI.
abstract: Follow-up observation is required for mild-to-moderate hydrocephalic patients because of the potential damage to brain. However, effects of mild-to-moderate hydrocephalus on gray and white matter remain unclear in vivo. Using structural MRI and diffusion tensor imaging (DTI), current study compared the cortical thickness and white matter integrity between children with mild-to-moderate communicating hydrocephalus and healthy controls. The relationships between cortical changes and intelligence quota were also examined in patients. We found that cortical thickness in the left middle temporal and left rostral middle frontal gyrus was significantly lower in the hydrocephalus group compared with that of controls. Fractional anisotropy in the right corpus callosum body was significantly lower in the hydrocephalus group compared with that of controls. In addition, there was no association of cortical thinning or white matter fractional anisotropy with intelligence quota in either group. Thus, our findings provide clues to that mild-to-moderate hydrocephalus could lead to structural brain deficits especially in the middle temporal and middle frontal gyrus prior to the behavior changes.
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Radiology Department, Meizhou People's Hospital, Meizhou, Guangdong, China.
authors.forename: Siyu
authors.identifier: 0000-0002-1949-4413
authors.initials: S
authors.lastname: Zhang
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Ye
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Bai
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Fu
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Chuanwan
authors.initials: C
authors.lastname: Mao
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Aiqin
authors.initials: A
authors.lastname: Wu
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Xiaozheng
authors.identifier: 0000-0002-1580-6942
authors.initials: X
authors.lastname: Liu
authors.affiliation: China-USA Neuroimaging Research Institute, Radiology Department of The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Zhihan
authors.identifier: 0000-0001-6826-7439
authors.initials: Z
authors.lastname: Yan
mesh_terms: D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*