title: Dendritic cell rehab: new strategies to unleash therapeutic immunity in ovarian cancer.
abstract: Immune-based therapies that induce remarkable and durable responses against melanoma and lung cancer have unfortunately demonstrated limited success in ovarian cancer patients. This is likely due to the exceptional immunoregulatory nature of ovarian tumors, which employ numerous strategies to effectively suppress anti-tumor immunity. Here, we summarize a decade of research indicating that ovarian cancers possess an exquisite capacity to subvert the activity of host dendritic cells (DCs) as a key mechanism to impede the development and maintenance of protective T cell-based immune responses. Identifying, understanding, and disabling the precise mechanisms promoting DC dysfunction in ovarian cancer are, therefore, fundamental requirements for devising the next generation of successful immunotherapies against this devastating malignancy.
authors.affiliation: Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.|Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
authors.forename: Chang-Suk
authors.initials: CS
authors.lastname: Chae
authors.affiliation: Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.|Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.|School of Nutrition Sciences, Autonomous University of Sinaloa, Culiacán, SIN, Mexico.
authors.forename: Eli
authors.initials: E
authors.lastname: Teran-Cabanillas
authors.affiliation: Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA. jur2016@med.cornell.edu.|Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. jur2016@med.cornell.edu.
authors.forename: Juan R
authors.identifier: http://orcid.org/0000-0002-4267-4893
authors.initials: JR
authors.lastname: Cubillos-Ruiz
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D007109:Immunity; D056747:Immunomodulation; D007167:Immunotherapy; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000628:therapy; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D019496:Cancer Vaccines
keywords: Dendritic cells; Immunosuppression; Immunotherapy; Ovarian cancer; Regulatory myeloid suppressor cells; Tumor microenvironment