title: Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome.
abstract: STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.
authors.affiliation: Department of Immunology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Stentzel
authors.affiliation: University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.|Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Munich/Augsburg, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Hagl
authors.affiliation: University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.
authors.forename: Felicitas
authors.initials: F
authors.lastname: Abel
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Germany.
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Kahl
authors.affiliation: University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.
authors.forename: Anita
authors.initials: A
authors.lastname: Rack-Hoch
authors.affiliation: Department of Immunology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany.
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Bröker
authors.affiliation: University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.|Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Munich/Augsburg, Germany.|Hochgebirgsklinik and Christine-Kühne-Center for Allergy Research and Education, Davos, Switzerland.
authors.forename: Ellen D
authors.initials: ED
authors.lastname: Renner
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007589:Job Syndrome / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
keywords: HIES; S. aureus; STAT3; Th17; adaptive immunity; cystic fibrosis; hyper-IgE Syndrome; specific IgG