title: PD-L1 over-expression is associated with a poor prognosis in Asian non-small cell lung cancer patients.
abstract: BACKGROUND
  The prognostic role of programmed cell death-ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis was conducted to clarify the association of PD-L1 with survival in NSCLC patients.
  
  
  METHODS
  Relevant studies were collected from PubMed, Embase and Web of Science. Only studies in which PD-L1 expression was detected by immunohistochemical staining in NSCLC patients correlated with patient survival data were included. Stata 12.0 was performed in this meta-analysis.
  
  
  RESULTS
  Fifteen studies with 3116 patients were included in this meta-analysis. The combined hazard ratio (HR) of 1.18 (95%CI, 0.90-1.56; P>0.05) shows that PD-L1 over-expression in NSCLC patients didn't associate with overall survival (OS). However, subgroup analysis indicated that PD-L1 over-expression was correlated with poor OS in Asian patients (HR=1.84, 95%CI: 1.14-2.28; P<0.001). Moreover, the results suggested that a significant relationship between PD-L1 expression and OS was also showed in studies with late stage (HR=1.27, 95%CI: 1.06-1.48; P=0.031), poor tumor differentiation (HR=1.86, 95%CI: 1.35-2.64; P=0.001) and anaplastic lymphoma kinase (ALK) translocation (HR=2.58, 95%CI: 1.03-5.78; P=0.028).
  
  
  CONCLUSIONS
  PD-L1 over-expression is correlated with a poor prognosis in Asian NSCLC patients.
authors.affiliation: Department of Cardiothoracic Surgery, Suzhou Dushuhu Public Hospital (Soochow University Multi-Disciplinary Polyclinic), Suzhou 215006, Jiangsu Province, People's Republic of China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Xia
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, People's Republic of China; Department of Orthopedics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200000, People's Republic of China.
authors.forename: Ji
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Hematology, Suzhou Dushuhu Public Hospital (Soochow University Multi-Disciplinary Polyclinic), Suzhou 215006, Jiangsu Province, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, People's Republic of China.
authors.forename: Shaomu
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, People's Republic of China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, People's Republic of China. Electronic address: 18860927660@163.com.
authors.forename: Yaozeng
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, People's Republic of China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Ma
mesh_terms: D044466:Asian People; D060890:B7-H1 Antigen / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D011379:Prognosis
chemical_list: D060890:B7-H1 Antigen; D014408:Biomarkers, Tumor; C423236:CD274 protein, human
keywords: Meta-analysis; Non-small cell lung cancer; Prognosis; Programmed cell death-ligand 1