title: Stimulating Central Carbon Metabolism to Re-sensitize Pseudomonas aeruginosa to Aminoglycosides.
abstract: In this issue of Cell Chemical Biology, Meylan et al. (2017) examine how stimulation of central carbon metabolism of Pseudomonas aeruginosa modulates aminoglycoside lethality in tolerant bacteria. They identify fumarate as a tobramycin potentiator that stimulates proton motive force-dependent drug uptake and increases respiration-dependent killing.
authors.affiliation: Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.
authors.forename: Dorival
authors.initials: D
authors.lastname: Martins
authors.affiliation: Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada; Department of Medicine, McGill University, Montréal, QC H4A 3J1, Canada. Electronic address: dao.nguyen@mcgill.ca.
authors.forename: Dao
authors.initials: D
authors.lastname: Nguyen
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002244:Carbon; D002952:Citric Acid Cycle; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002244:Carbon