title: GM-CSF Autoantibody-positive Pulmonary Alveolar Proteinosis with Simultaneous Myeloproliferative Neoplasm.
abstract: Pulmonary alveolar proteinosis (PAP) is classified as autoimmune, secondary, or genetic. We herein describe a 69-year-old man with autoimmune PAP, simultaneously diagnosed with myeloproliferative neoplasm (MPN). Two years after the diagnosis, the MPN progressed to acute myeloid leukemia, and the patient died from an alveolar hemorrhage during remission induction chemotherapy. Throughout the clinical course, no progression of PAP was observed, despite the progression to leukemia. There are few reports of autoimmune PAP with hematological malignancy, and this case demonstrated that an evaluation for GM-CSF autoantibodies is important for distinguishing the autoimmune and secondary forms of PAP, even if the patient has hematological malignancy.
authors.affiliation: Division of Hematology and Oncology, Ogaki Municipal Hospital, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Imoto
authors.forename: Nakashima
authors.initials: N
authors.lastname: Harunori
authors.forename: Katsuya
authors.initials: K
authors.lastname: Furukawa
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Tange
authors.forename: Atsushi
authors.initials: A
authors.lastname: Murase
authors.forename: Masaya
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ichihara
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Iwata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kosugi
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D001706:Biopsy; D018450:Disease Progression; D017809:Fatal Outcome; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology; D008168:Lung / Q000473:pathology; D008297:Male; D009196:Myeloproliferative Disorders / Q000209:etiology*; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D016178:Granulocyte-Macrophage Colony-Stimulating Factor