title: CBr4as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones.
abstract: CBr4has been employed as a halogen bond donor catalyst for the selective activation of aldehyde, to achieve an efficient solvent- and metal-free C═C bond forming reaction in the presence of strong acid sensitive groups such as methoxy, cyanide, ester, and ketal for the synthesis of α,β-unsaturated ketones. This unique capability of CBr4to act as a halogen bond donor has been explored and established using UV-vis as well as IR spectroscopy. Moreover, this unprecedented methodology enables the synthesis of the pharmaceutically important molecule licochalcone A.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai, 600036, India.
authors.forename: Imran
authors.initials: I
authors.lastname: Kazi
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai, 600036, India.
authors.forename: Somraj
authors.initials: S
authors.lastname: Guha
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai, 600036, India.
authors.forename: Govindasamy
authors.identifier: 0000-0003-2294-0485
authors.initials: G
authors.lastname: Sekar