title: Iron-Catalyzed Synthesis of Oxindoles: Application to the Preparation of Pyrroloindolines.
abstract: A novel and highly efficient synthetic approach to pyrroloindolines has been developed. The process is based on tandem radical addition/cyclization with inexpensive iron catalyst. This method tolerates a wide range of N-methyl-N-arylacrylamides as well carbamoyl radicals, providing access to a variety of functionalized 3,3-disubstituted oxindoles, key intermediates for many bioactive pyrroloindolines such as (±)-esermethole, (±)-deoxyeseroline, and (±)-physovenol methyl ether.
authors.affiliation: Departament of Fundamental Chemistry, Institute of Chemistry, University of São Paulo , Av. Prof. Lineu Prestes 748, 05508-900, São Paulo, Brazil.
authors.forename: Valquírio G
authors.initials: VG
authors.lastname: Correia
authors.affiliation: Departament of Fundamental Chemistry, Institute of Chemistry, University of São Paulo , Av. Prof. Lineu Prestes 748, 05508-900, São Paulo, Brazil.
authors.forename: Juliana C
authors.initials: JC
authors.lastname: Abreu
authors.affiliation: Departament of Fundamental Chemistry, Institute of Chemistry, University of São Paulo , Av. Prof. Lineu Prestes 748, 05508-900, São Paulo, Brazil.
authors.forename: Caio A E
authors.initials: CA
authors.lastname: Barata
authors.affiliation: Departament of Fundamental Chemistry, Institute of Chemistry, University of São Paulo , Av. Prof. Lineu Prestes 748, 05508-900, São Paulo, Brazil.
authors.forename: Leandro H
authors.identifier: 0000-0001-5975-4980
authors.initials: LH
authors.lastname: Andrade