title: Quantitative Analysis of En Face Spectral-Domain Optical Coherence Tomography Imaging in Polypoidal Choroidal Vasculopathy.
abstract: Spectral-domain optical coherence tomography (SD-OCT) imaging can be used to visualize polypoidal choroidal vasculopathy (PCV) lesions in the en face plane. Here, the authors describe a novel lesion quantification technique and compare PCV lesion area measurements and morphology before and after anti-vascular endothelial growth factor (VEGF) treatment.
  
  
  
  Volumetric SD-OCT scans in eyes with PCV before and after induction anti-VEGF therapy were retrospectively analyzed. En face SD-OCT images were generated and a pixel intensity thresholding process was used to quantify total lesion area.
  
  
  
  Thirteen eyes with PCV were analyzed. En face SD-OCT PCV lesion area quantification showed good intergrader reliability (intraclass correlation coefficient = 0.944). Total PCV lesion area was significantly reduced after anti-VEGF therapy (2.22 mm2vs. 2.73 mm2; P = .02). The overall geographic pattern of the branching vascular network was typically preserved.
  
  
  
  PCV lesion area analysis using en face SD-OCT is a reproducible tool that can quantify treatment related changes. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:126-133.].
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Simonett
authors.forename: Errol W
authors.initials: EW
authors.lastname: Chan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Chou
authors.forename: Dimitra
authors.initials: D
authors.lastname: Skondra
authors.forename: Daniel
authors.initials: D
authors.lastname: Colon
authors.forename: Caroline K
authors.initials: CK
authors.lastname: Chee
authors.forename: Gopal
authors.initials: G
authors.lastname: Lingam
authors.forename: Amani A
authors.initials: AA
authors.lastname: Fawzi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000175:diagnosis*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*