title: Age-adjusted charlson comorbidity index score as predictor of prolonged postoperative ileus in patients with colorectal cancer who underwent surgical resection.
abstract: Comorbidities had considerable effects on the development of postoperative ileus (POI). The primary aim of the present study was to determine the influence of the age-adjusted Charlson comorbidity index (ACCI) score on the risk of prolonged POI in patients with colorectal cancer who underwent surgical resection. Using the electronic Hospitalization Summary Reports, we identified 11,397 patients with colorectal cancer who underwent surgical resection from 2013 through 2015. Logistic regression models were applied to evaluate the effect of the ACCI score on the risk of prolonged POI. The ACCI score had a positive graded association with the risk of prolonged POI in both colon and rectal cancer (P for trend < 0.05). Among patients with rectal cancer, after adjusting for potential confounders, those with an ACCI score of 4-5 had a 108% higher risk of prolonged POI than those with an ACCI score of 0-1 (odds ratio [OR], 2.08; 95% confidence interval [CI], 1.09-3.98), and those with an ACCI score of ≥ 6 had a 130% higher risk (OR, 2.30; 95% CI, 1.08-4.89). Among patients with colon cancer, those with an ACCI score of ≥ 6 had a 47% greater risk of prolonged POI than those with an ACCI score of 0-1 (OR, 1.47; 95% CI, 1.07-2.02). These findings suggested that a higher ACCI score was an independent predictor of the development of prolonged POI.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 100191 Beijing, China.
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Medical Informatics Center, Peking University, 100191 Beijing, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Xu
authors.affiliation: Medical Informatics Center, Peking University, 100191 Beijing, China.
authors.forename: Guopei
authors.initials: G
authors.lastname: Yu
authors.affiliation: National Healthcare Data Center, Affiliated to National Center for Medical Service Administration, 100191 Beijing, China.|Hospital Administration Department, Peking University, 100191 Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Medical Informatics Center, Peking University, 100191 Beijing, China.|National Healthcare Data Center, Affiliated to National Center for Medical Service Administration, 100191 Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000601:surgery*; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D045823:Ileus / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: age-adjusted charlson comorbidity index; colorectal cancer; prolonged postoperative ileus; surgery; surgical resection