title: Beat-to-Beat Blood Pressure and Two-dimensional (axial and radial) Motion of the Carotid Artery Wall: Physiological Evaluation of Arterial Stiffness.
abstract: The physiological relationship between local arterial displacement and blood pressure (BP) plays an integral role in assess- ment of the mechanical properties of arteries. In this study, we used more advanced methods to obtain reliable continuous BP and the displacement of the common carotid artery (CCA) simultaneously. We propose a novel evaluation method for arterial stiffness that relies on determining the physiological relationship between the axial and radial displacements of the CCA wall and beat-to-beat BP. Patients (total of 138) were divided into groups according to the following three criteria: essential hyper- tension (EH) and normotension, male and female, elderly and younger. The Pearson correlation test and canonical correlation analysis showed that the CCA indices were significantly correlated with BP indices (r = 0:787; p < 0:05). The slope of the CCA displacement/pressure curve showed a progressive reduction with increasing age and EH disease occurrence (EH: 0.496 vs. normotension: 0.822; age <= 60:0.585 vs. age > 60:0.783). Our method provides an explicit reference value and relationship for the manner in which the CCA wall responds to changes in BP. Short-term and continuous BP were significantly correlated with CCA displacement and exhibited a close inverse relationship with each subject's BP and EH, age, and systolic blood pressure.
authors.affiliation: School of computer Science and Technology, Anhui University, Hefei, 230601, China.
authors.forename: Chenchu
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Ultrasound, Shenzhen Second People's Hospital, Shenzhen, 518000, China.
authors.forename: Huahua
authors.initials: H
authors.lastname: Xiong
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.|Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, 518055, China.
authors.forename: Zhifan
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
authors.forename: Heye
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of computer Science and Technology, Anhui University, Hefei, 230601, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of computer Science and Technology, Anhui University, Hefei, 230601, China.
authors.forename: Xiuquan
authors.initials: X
authors.lastname: Du
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of computer Science and Technology, Anhui University, Hefei, 230601, China.
authors.forename: Guotao
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Medical Imaging, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond St, London ON, Canada.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009038:Motion; D012737:Sex Factors; D059289:Vascular Stiffness / Q000502:physiology*