title: Viperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages.
abstract: Viperin is an antiviral protein that is upregulated by interferons and by ligands for a variety of innate immune receptors. It possesses diverse capabilities and functions in an array of viral infections. Studies have shown that it appears to be particularly important in defence against RNA viruses, such as West Nile, Dengue, and Chikungunya viruses, although the specific mechanisms involved are not well understood at the molecular level. Here we identify the mitochondrial antiviral signalling protein MAVS as a novel viperin interaction partner, most likely in mitochondria associated membranes, and characterize a more central, overarching role of viperin as a negative regulator of the interferon response, an ability that can be regulated by the viperin-MAVS interaction. This suggests a novel mechanism of viperin action in immune defence against RNA viruses by which it may prevent pathology from excessive immune responses.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Jia Shee
authors.identifier: http://orcid.org/0000-0002-2782-1613
authors.initials: JS
authors.lastname: Hee
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Peter
authors.initials: P
authors.lastname: Cresswell
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D007372:Interferons / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008928:Mitochondria / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D000090123:Viperin Protein
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000998:Antiviral Agents; D007372:Interferons; D011506:Proteins; C512612:MAVS protein, mouse; C417529:Rsad2 protein, mouse; D000090123:Viperin Protein