title: Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity.
abstract: Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known regarding the contribution of these cells to the pathogenesis of autoimmune disorders. Recent studies have aimed to clarify certain important factors affecting the immunogenicity of these cells, including the type and dose of antigen, the microenvironment of the cell-antigen encounter, and the number, subset, and phenotype of these cells, which can prevent or induce autoimmune responses. This review highlights the role of macrophage subsets and neutrophils in injured tissues, supporting their cooperation during the pathogenesis of certain autoimmune diseases.
authors.affiliation: Pharmaceutical Science Post-Graduation Program, Health Science Institute, Federal University of Pará/UFPA, Belém, PA, 66075900, Brazil.
authors.forename: Kely Campos
authors.initials: KC
authors.lastname: Navegantes
authors.affiliation: Pharmaceutical Science Post-Graduation Program, Health Science Institute, Federal University of Pará/UFPA, Belém, PA, 66075900, Brazil.
authors.forename: Rafaelli
authors.initials: R
authors.lastname: de Souza Gomes
authors.affiliation: Department of Clinical, Bromatological and Toxicological Analysis, Ribeirão Preto Pharmaceutical Sciences School, USP-SP, Ribeirão Preto, SP, Brazil.
authors.forename: Priscilla Aparecida Tártari
authors.initials: PAT
authors.lastname: Pereira
authors.affiliation: College of Pharmacy, Guairacá Faculty-PR, Guarapuava, PR, Brazil.
authors.forename: Paula Giselle
authors.initials: PG
authors.lastname: Czaikoski
authors.affiliation: Pharmaceutical Science Post-Graduation Program, Health Science Institute, Federal University of Pará/UFPA, Belém, PA, 66075900, Brazil.
authors.forename: Carolina Heitmann Mares
authors.initials: CHM
authors.lastname: Azevedo
authors.affiliation: Pharmaceutical Science Post-Graduation Program, Health Science Institute, Federal University of Pará/UFPA, Belém, PA, 66075900, Brazil. martachagas2@yahoo.com.br.
authors.forename: Marta Chagas
authors.initials: MC
authors.lastname: Monteiro
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000473:pathology; D008264:Macrophages / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*
keywords: Autoimmune disease; Autoimmunity; Inflammation; Macrophages; Neutrophils