title: Expression pattern of heat shock protein 90 in patients with oral squamous cell carcinoma in northern Taiwan.
abstract: Heat shock protein 90 (HSP90), which is expressed in cancer cells, profoundly affects progression, invasion, and metastasis. However, to our knowledge, in East Asia, the correlation between the expression of HSP90 and clinicopathological variables has seldom been discussed. We therefore investigated this and its prognostic value in 36 patients newly diagnosed with oral squamous cell carcinoma (SCC) in northern Taiwan. Samples of tumour and normal samples from the patients were compared immunohistochemically. HSP90 was expressed mainly in the samples of tumour, and was significantly higher in these than in the normal epithelium (p<0.001). Metastases to the lymph nodes in the 36 patients also correlated with expression of HSP90. Correlation between expression of HSP90 and the size of the tumour or pathological staging was not significant, but strong expression correlated with poor survival. In general, expression was low among our samples (30/36). It was significantly higher in the tumour samples than in normal samples, and correlated with metastases to lymph nodes in the neck.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: W-C
authors.initials: WC
authors.lastname: Chang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: P-T
authors.initials: PT
authors.lastname: Tsai
authors.affiliation: Department of Pathology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan, Republic of China; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: C-K
authors.initials: CK
authors.lastname: Lin
authors.affiliation: Department of Operative Dentistry and Endodontology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: Y-S
authors.initials: YS
authors.lastname: Shieh
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China. Electronic address: h6183@yahoo.com.tw.
authors.forename: Y-W
authors.initials: YW
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D015996:Survival Rate; D013624:Taiwan
chemical_list: D018841:HSP90 Heat-Shock Proteins
keywords: Expression pattern; Heat shock protein 90; Oral squamous cell carcinoma