title: [Multiple thrombophilic risk markers in patients ≺65 years of age with retinal vein occlusion].
abstract: BACKGROUND
  The potential impact of multiple thrombophilic defects on retinal venous occlusive (RVO) diseases with regard to age and various risk factors has not been studied extensively.
  
  
  METHODS
  In a retrospective, multicenter study, thrombophilia data of 128 patients <65 years of age with RVO and 110 healthy subjects were evaluated. The main measure outcome was the prevalence of multiple thrombophilic disorders.
  
  
  RESULTS
  Multiple thrombophilic defects were significantly more prevalent among RVO patients (18.0%) than among controls (1.8%; P < 0.0001). We identified factor VIII elevation, elevated lipoprotein(a) plasma levels and resistance to activated protein C as the most prevalent combined disorders. Factor XII deficiency and prothrombin mutation G20210A were found to be isolated thrombophilic risk factors. Multiple thrombophilic defects were significantly associated with RVO recurrence (P = 0.008).
  
  
  CONCLUSIONS
  Multiple thrombophilic disorders are associated with the development of RVO among patients younger than 65 years of age. Moreover, our results suggest that patients with RVO associated with underlying combined thrombophilic defects are at increased risk for RVO recurrence. Further studies are required to analyze whether the diagnosis of combined thrombophilic defects among RVO patients could be a predictor for RVO recurrence.
authors.affiliation: Klinik für Augenheilkunde, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland. hattenbach@med.uni-frankfurt.de.
authors.forename: C
authors.initials: C
authors.lastname: Kuhli-Hattenbach
authors.affiliation: Klinik für Hämostaseologie und Transfusionsmedizin, Klinikum Ludwigshafen, Ludwigshafen am Rhein, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Hellstern
authors.affiliation: Medizinische Klinik II, Institut für Transfusionsmedizin und Immunhämatologie, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Miesbach
authors.affiliation: Klinik für Augenheilkunde, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Kohnen
authors.affiliation: Augenklinik des Klinikums Ludwigshafen, Ludwigshafen am Rhein, Deutschland.
authors.forename: L-O
authors.initials: LO
authors.lastname: Hattenbach
mesh_terms: D015415:Biomarkers; D006801:Humans; D012170:Retinal Vein Occlusion; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia
chemical_list: D015415:Biomarkers
keywords: APC resistance; Coagulation disorders; Lipid metabolism; Retinal vein occlusion; Thrombophilia