title: Effect of antiplatelet therapy on aneurysmal sac expansion associated with type II endoleaks after endovascular aneurysm repair.
abstract: Endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAAs) has gained widespread use through a solid reputation of safety and effectiveness. However, some issues, such as endoleaks and sac growth over time, still arise as important concerns. Antiplatelet therapy, mandatory as secondary prevention of cardiovascular disease, may play a role in both phenomena by interfering with blood clotting properties and the inflammatory process associated with AAA. We analyzed whether different antiplatelet therapies were independent risk factors for type II endoleak (T2E) persistence and midterm sac growth after EVAR.
  
  
  
  All patients with T2E detected in the first post-EVAR control were included, except those without at least 1 year of complete follow-up. Data for demographics, clinical comorbidities, EVAR devices, and antiplatelet therapies were recorded. All patients underwent routine follow-up with contrast-enhanced tomography at 1 month, 6 months, 12 months, and annually thereafter. A three-dimensional rendering of each endoleak was performed for detailed volumetry. Main outcomes were endoleak persistence at 6 months and sac growth >5 mm at end of follow-up.
  
  
  
  During a 9-year period, 87 patients with initial T2E were monitored for a mean of 41.5 months. On discharge, salicylates were prescribed to 50, clopidogrel to 16, and multiagent therapy or anticoagulation to 9; no therapy was given to 12. No significant differences in comorbidities or baseline AAA characteristics were found between groups. At 6 months thereafter, 59% (n = 51) of the initial T2Es persisted. At end of follow-up, 32 patients had sac growth >5 mm (37%). Sac growth was significantly less frequent in the group treated with salicylates (26% vs 60%; P = .004). Cox proportional hazards model reinforced the role of salicylates as protectors for sac growth over time (hazard ratio, 0.34; 95% confidence interval, 0.13-0.87; P = .024), whereas T2E nidus volume and endoleak complexity behaved like independent risk factors.
  
  
  
  Antiplatelet therapy with salicylates appears to be linked to a decreased risk of sac growth >5 mm over time in patients with T2Es detected right after EVAR. Population-based cohort studies are mandatory to confirm this finding and to guide a potential recommendation.
authors.affiliation: Vascular Surgery Department, A Coruña University Healthcare Complex (CHUAC), A Coruña, Spain. Electronic address: alvarezmarcos@seacv.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Álvarez Marcos
authors.affiliation: Vascular Surgery Department, Asturias University Central Hospital (HUCA), Oviedo, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Llaneza Coto
authors.affiliation: Vascular Surgery Department, A Coruña University Healthcare Complex (CHUAC), A Coruña, Spain.
authors.forename: Francisco José
authors.initials: FJ
authors.lastname: Franco Meijide
authors.affiliation: Vascular Surgery Department, Asturias University Central Hospital (HUCA), Oviedo, Spain.
authors.forename: Ahmad Amer
authors.initials: AA
authors.lastname: Zanabili Al-Sibbai
authors.affiliation: Vascular Surgery Department, A Coruña University Healthcare Complex (CHUAC), A Coruña, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Vilariño Rico
authors.affiliation: Vascular Surgery Department, Asturias University Central Hospital (HUCA), Oviedo, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Alonso Pérez
authors.affiliation: Vascular Surgery Department, A Coruña University Healthcare Complex (CHUAC), A Coruña, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Caeiro Quinteiro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery*; D001027:Aortography / Q000379:methods; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D016009:Chi-Square Distribution; D000077144:Clopidogrel; D000072226:Computed Tomography Angiography; D003287:Contrast Media / Q000008:administration & dosage; D016208:Databases, Factual; D004359:Drug Therapy, Combination; D057867:Endoleak / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D057510:Endovascular Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D003287:Contrast Media; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin