title: Prediction and Analysis of Key Genes in Glioblastoma Based on Bioinformatics.
abstract: Understanding the mechanisms of glioblastoma at the molecular and structural level is not only interesting for basic science but also valuable for biotechnological application, such as the clinical treatment. In the present study, bioinformatics analysis was performed to reveal and identify the key genes of glioblastoma multiforme (GBM). The results obtained in the present study signified the importance of some genes, such as COL3A1, FN1, and MMP9, for glioblastoma. Based on the selected genes, a prediction model was built, which achieved 94.4% prediction accuracy. These findings might provide more insights into the genetic basis of glioblastoma.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Long
authors.affiliation: Department of Neurosurgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510665, China.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Xi'an
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Luxiong
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Qi
authors.affiliation: Department of General Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Haizhong
authors.identifier: 0000-0002-1573-9655
authors.initials: H
authors.lastname: Huo
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Ye
authors.identifier: 0000-0003-3101-1143
authors.initials: Y
authors.lastname: Song
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D005453:Fluorescence; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D063990:Gene Ontology; D052138:Genes, Neoplasm; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D060066:Protein Interaction Maps / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics