title: Efficacy of salpingectomy at hysterectomy to reduce the risk of epithelial ovarian cancer: a systematic review.
abstract: It has been argued that salpingectomy would reduce the risk of epithelial ovarian cancer (EOC), based on the theory of the tube being the site of origin.
  
  
  
  To conduct a systematic review of 'salpingectomy' associated with ovarian cancer risk and 'salpingectomy with concomitant hysterectomy' on outcomes of complications including endocrine function.
  
  
  
  A comprehensive search was conducted in PubMed, Embase, and the Cochrane library.
  
  
  
  Original studies and systematic reviews were eligible.
  
  
  
  Each article was quality assessed. Data were extracted and, when possible, pooled in meta-analyses. The certainty of evidence across studies was evaluated using GRADE.
  
  
  
  Of 844 articles found, 11 were included. No study evaluated risk reduction for EOC after salpingectomy in conjunction with hysterectomy. Two retrospective studies reported a reduced ovarian cancer risk after indicated salpingectomy, compared with no surgery: adjusted hazard ratio 0.65 (95% confidence interval, 95% CI 0.52-0.81) and adjusted odds ratio 0.58 (95% CI 0.36-0.95). Complications did not differ between groups with or without salpingectomy, but were non-systematically reported. Ovarian endocrine function, measured with surrogate outcomes, did not differ at short-term follow-up in randomised or observational studies. The certainty of evidence was very low or low for all outcomes.
  
  
  
  There is currently insufficient evidence to state that opportunistic salpingectomy reduces the risk of EOC. The impact on long-term endocrine function is unknown. The heterogeneity in results and identified knowledge gaps stress the need for a prospective trial.
  
  
  
  Insufficient evidence for prophylactic removal of the fallopian tubes for risk reduction of ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Darelius
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lycke
authors.affiliation: HTA-centrum, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: J M
authors.initials: JM
authors.lastname: Kindblom
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Kristjansdottir
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden.|Sahlgrenska Cancer Centre, Göteborg, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Sundfeldt
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden.|HTA-centrum, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Strandell
mesh_terms: D000328:Adult; D000077216:Carcinoma, Ovarian Epithelial / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D008875:Middle Aged; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000209:etiology / Q000517:prevention & control*; D065286:Prophylactic Surgical Procedures / Q000379:methods*; D012307:Risk Factors; D058994:Salpingectomy / Q000379:methods*; D016896:Treatment Outcome
keywords: Hysterectomy; opportunistic salpingectomy; ovarian cancer risk reduction