title: Neonatology oxidative status in preterm infants with premature preterm rupture of membranes and fetal inflammatuar response syndrome.
abstract: The aim of this study, to determine an index of oxidative stress index in preterm infants less than 34 weeks gestational age with premature preterm rupture of membrane (PPROM) and fetal inflammatory response syndrome (FIRS).
  
  
  
  This study was designed as a prospective study. Fifty-one premature infants less than 35 weeks of gestational age were included in the study. The umbilical cord blood concentrations of IL-6, TAC (total antioxidant capacity) and PON-1 (paraoxonase-1) levels and TOS (total oxidative stress) were studied. The oxidative stress index (OSI = TAC/TOS) was calculated in all of prematüre infants. PPROM was defined as rupture of membranes at least 24 hours before the onset of labor. FIRS was defined by an umbilical cord IL-6 level greater than 11 pg/mL. Premature infants included in the study were divided into 4 groups. Group 1 included preterm infants without FIRS and with PPROM (n = 16), while Group 2 included preterm infants without PPROM and with FIRS (n = 9), Group 3 consisted of premature infants with PPROM and FIRS (n = 21) and Group 4 included premature infants without PPROM or FIRS (n = 5).
  
  
  
  Umbilical cord TOS level was found to be higher in the preterm infants without FIRS and with PPROM (36.1 μmol H2O2Equiv./L) compared to the preterm infants without PPROM or FIRS (11.9 μmol H2O2Equiv./L) (p = 0.03). Umbilical cord PON-1 level was found to be lower in the preterms without FIRS and with PPROM (32 U/L), preterms without PPROM and with FIRS (30. 3 U/L) and the preterm infants with both PPROM and FIRS (48.6 U/L) compared to the preterm infants having no PPROM or FIRS (85.6 U/L) (p = 0.001).
  
  
  
  High pro-oxidant capacity was found in PPROM and low antioxidant capacity in PPROM and FIRS.
authors.affiliation: Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children Training and Research Hospital, İstanbul, Turkey. Electronic address: elifozalkay@gmail.com.
authors.forename: Elif
authors.initials: E
authors.lastname: Özalkaya
authors.affiliation: Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children Training and Research Hospital, İstanbul, Turkey.
authors.forename: Güner
authors.initials: G
authors.lastname: Karatekin
authors.affiliation: Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children Training and Research Hospital, İstanbul, Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Topçuoğlu
authors.affiliation: Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children Training and Research Hospital, İstanbul, Turkey.
authors.forename: Hande Özgün
authors.initials: HÖ
authors.lastname: Karatepe
authors.affiliation: Neonatal Intensıve Care Unit, Sakarya University, Sakarya, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Hafızoğlu
authors.affiliation: Departments of Biochemistry Laboratory, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: Pervin
authors.initials: P
authors.lastname: Baran
authors.affiliation: Neonatal Intensıve Care Unit, Istanbul Medeniyet University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Fahri
authors.initials: F
authors.lastname: Ovalı
mesh_terms: D043303:Aryldialkylphosphatase / Q000378:metabolism; D005260:Female; D005312:Fetal Blood; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications / Q000378:metabolism*
chemical_list: D015850:Interleukin-6; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: oxidative status; preterm infant