title: Toward the automatic quantification of in utero brain development in 3D structural MRI: A review.
abstract: Investigating the human brain in utero is important for researchers and clinicians seeking to understand early neurodevelopmental processes. With the advent of fast magnetic resonance imaging (MRI) techniques and the development of motion correction algorithms to obtain high-quality 3D images of the fetal brain, it is now possible to gain more insight into the ongoing maturational processes in the brain. In this article, we present a review of the major building blocks of the pipeline toward performing quantitative analysis of in vivo MRI of the developing brain and its potential applications in clinical settings. The review focuses on T1- and T2-weighted modalities, and covers state of the art methodologies involved in each step of the pipeline, in particular, 3D volume reconstruction, spatio-temporal modeling of the developing brain, segmentation, quantification techniques, and clinical applications. Hum Brain Mapp 38:2772-2787, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: DTIC, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Oualid M
authors.identifier: 0000-0003-3922-7643
authors.initials: OM
authors.lastname: Benkarim
authors.affiliation: DTIC, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Sanroma
authors.affiliation: DTIC, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Veronika A
authors.initials: VA
authors.lastname: Zimmer
authors.affiliation: Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Spain.|Experimental 7T MRI Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Emma
authors.initials: E
authors.lastname: Muñoz-Moreno
authors.affiliation: Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Spain.
authors.forename: Nadine
authors.initials: N
authors.lastname: Hahner
authors.affiliation: Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Spain.
authors.forename: Elisenda
authors.initials: E
authors.lastname: Eixarch
authors.affiliation: DTIC, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Camara
authors.affiliation: DTIC, Universitat Pompeu Fabra, Barcelona, Spain.|ICREA, Barcelona, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: González Ballester
authors.affiliation: DTIC, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Piella
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000196:embryology / Q000254:growth & development; D001330:Electronic Data Processing; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging
keywords: fetal brain; growth pattern; gyrification; quantitative MRI; segmentation; spatiotemporal atlas; ventriculomegaly; volumetry