title: Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women.
abstract: Background:To our knowledge, no previous study has evaluated the associations of antioxidant intake with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease.Objective:We sought to evaluate these associations among 406 ovarian cancer cases and 632 age- and site-matched controls of African-American descent recruited from AACES (African American Cancer Epidemiology Study), a population-based, case-control study in 11 geographical areas within the United States.Methods:Multivariable logistic regression models were used to estimate ORs and 95% CIs adjusted for a wide range of potentially confounding factors, including age, region, education, parity, oral contraceptive use, menopause, tubal ligation, family history, body mass index (BMI), smoking status, total energy, and physical activity.Results:Women with the highest intakes of supplemental selenium (>20 μg/d) had an ∼30% lower risk of ovarian cancer than those with no supplemental intake (OR: 0.67; 95% CI: 0.46, 0.97;P-trend = 0.035). This inverse association was stronger in current smokers (OR: 0.13; 95% CI: 0.04, 0.46;P-trend = 0.001). There was no association with dietary selenium. The associations with carotenoid intakes were weak and nonsignificant (P= 0.07-0.60). We observed no association with dietary or supplemental intake of vitamin C or vitamin E. There were no appreciable differences in results between serous and nonserous tumors.Conclusions:These findings provide the first insights, to our knowledge, into the potential association between antioxidants and ovarian cancer in African-American women, indicating potential inverse associations with supplemental selenium.
authors.affiliation: Department of Medicine, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN; pdterry@utk.edu.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Terry
authors.affiliation: Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.
authors.forename: Bo
authors.initials: B
authors.lastname: Qin
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Fabian
authors.initials: F
authors.lastname: Camacho
authors.affiliation: Department of Community and Family Medicine, Duke Cancer Institute, Durham, NC.
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Moorman
authors.affiliation: Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Alberg
authors.affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH.
authors.forename: Jill S
authors.initials: JS
authors.lastname: Barnholtz-Sloan
authors.affiliation: Cancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, TX.
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
authors.affiliation: Department of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Cote
authors.affiliation: Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL; and.
authors.forename: Ellen
authors.initials: E
authors.lastname: Funkhouser
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Guertin
authors.affiliation: Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA.
authors.forename: Edward S
authors.initials: ES
authors.lastname: Peters
authors.affiliation: Department of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Ann G
authors.initials: AG
authors.lastname: Schwartz
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
authors.forename: Joellen M
authors.initials: JM
authors.lastname: Schildkraut
authors.affiliation: Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.
authors.forename: Elisa V
authors.initials: EV
authors.lastname: Bandera
mesh_terms: D001741:Black or African American; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000517:prevention & control*; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012643:Selenium
keywords: African American; antioxidants; diet; ovarian cancer; women