title: Caenorhabditis elegans as a model for understanding ROS function in physiology and disease.
abstract: ROS (reactive oxygen species) are potentially damaging by-products of aerobic metabolism which, unchecked, can have detrimental effects on cell function. However, it is now widely accepted that, at physiological levels, certain ROS play important roles in cell signaling, acting as second messengers to regulate cell choices that contribute to the development, adaptation and survival of plants and animals. Despite important recent advances in the biochemical tools available to study redox-signaling, the molecular mechanisms underlying most of these responses remain poorly understood, particularly in multicellular organisms. As we will review here, C. elegans has emerged as a powerful animal model to elucidate these and other aspects of redox biology.
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain. Electronic address: amiranda-ibis@us.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Miranda-Vizuete
authors.affiliation: Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Institute for Ageing, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address: e.a.veal@ncl.ac.uk.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Veal
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D008136:Longevity / Q000235:genetics*; D023421:Models, Animal; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species
keywords: Aging; Caenorhabditis elegans; Cuticle; Innate immunity; Pathogen infection; ROS detection; Reactive oxygen species; Redox homeostasis; Wound healing