title: Development of nanostructured lipid carriers for the encapsulation and controlled release of vitamin D3.
abstract: Nanostructured lipid carriers (NLCs) for encapsulating vitamin D3 (VD3), a lipophilic vitamin, were successfully fabricated by hot high pressure homogenization. The physicochemical properties of the VD3-NLCs were characterized, and the release profiles of VD3 in simulated gastrointestinal fluids were investigated. Optimum VD3-NLCs were obtained with a small diameter (132.9nm), a high zeta potential (-41.90mV), and a high encapsulation efficiency (85.6%). The stability of the VD3-NLCs was tested during 20days of storage at 25°C under a wide range of pHs. In vitro digestion in simulated gastrointestinal fluids demonstrated their capability for controlled release because the NLCs were able to remain stable and protect the VD3 in simulated stomach fluid, but released more than 90% of the VD3 in simulated intestinal fluid. Therefore, the developed NLCs are promising carriers for increasing the oral bioavailability of VD3.
authors.affiliation: Department of Food Science and Technology, Keimyung University, Daegu 42601, Republic of Korea.
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Food Science and Technology, Keimyung University, Daegu 42601, Republic of Korea.
authors.forename: Coralia V
authors.initials: CV
authors.lastname: Garcia
authors.affiliation: Department of Food and Nutrition, Kunsan National University, Kunsan 54150, Republic of Korea. Electronic address: winnie19@kunsan.ac.kr.
authors.forename: Gye Hwa
authors.initials: GH
authors.lastname: Shin
authors.affiliation: Department of Food Science and Technology, Keimyung University, Daegu 42601, Republic of Korea. Electronic address: jtkim92@kmu.ac.kr.
authors.forename: Jun Tae
authors.initials: JT
authors.lastname: Kim
mesh_terms: D002762:Cholecalciferol / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008055:Lipids; D002762:Cholecalciferol
keywords: High pressure homogenization; Nanoencapsulation; Nanostructured lipid carriers; Stability; Vitamin D3