title: Effects of Metabolically Healthy and Unhealthy Obesity on Prolongation of Corrected QT Interval.
abstract: Although obesity and the metabolic syndrome (MS) often co-occur, many obese (OB) subjects have a favorable metabolic profile. It is unclear whether these factors independently influence cardiac electrophysiology including prolongation of the QT interval. We examined associations among obesity, MS, and prolonged corrected QT (QTc) interval in a large sample of Chinese research participants aged ≥35 years recruited from rural areas of Liaoning Province during 2012 to 2013. Of the 11,209 participants, 6,364 (56.8%) were nonobese and metabolically healthy (OB-/MS-), 2,853 (25.5%) were OB-/MS+, 493 (4.4%) were OB+/MS-, and 1,499 (13.4%) were OB+/MS+. Mean (±SD) QTc intervals were higher in OB-/MS+ (436.3 ± 24.3) and OB+/MS+ (436.6 ± 25.9) participants but not OB+/MS- participants (425.4 ± 24.0) than in OB-/MS- participants (426.8 ± 21.5, p <0.001), and the prevalence of QTc prolongation was higher in OB-/MS+ and OB+/MS+ participants (adjusted odds ratios [aOR] 1.68, 95% confidence interval [CI] 1.52 to 1.85; aOR 1.92, 95% CI 1.69 to 2.17, respectively) compared with OB-/MS- group but not in OB+/MS- participants (aOR 0.92, 95% CI 0.73 to 1.15). Prevalence increased with each MS component (aOR 1.27, 95% CI 1.22 to 1.32) but not with body mass index (aOR 1.01, 95% CI 0.99 to 1.02). In conclusion, prolonged QTc interval is associated with the MS and not independently associated with obesity.
authors.affiliation: Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Institute of Chronic Disease, Liaoning Provincial Center for Disease Control and Prevention, Shenyang, Liaoning, People's Republic of China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Pan
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China. Electronic address: yxsun@cmu.edu.cn.
authors.forename: Yingxian
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Pletcher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008133:Long QT Syndrome / Q000453:epidemiology*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D012424:Rural Population