title: Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles AgainstCandida albicans.
abstract: Four phthalazinones (CIDs 22334057, 22333974, 22334032, 22334012) and one isoquinolone (CID 5224943) were previously shown to be potent enhancers of antifungal activity of fluconazole againstCandida albicans. Several even more potent analogues of these compounds were identified, some with EC50as low as 1 nM, againstC. albicans. The compounds exhibited pharmacological synergy (FIC < 0.5) with fluconazole. The compounds were also shown to enhance the antifungal activity of isavuconazole, a recently FDA approved azole antifungal. Isoquinolone15and phthalazinone24were shown to be active against several resistant clinical isolates ofC. albicans.
authors.affiliation: Department of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Mood
authors.affiliation: Department of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
authors.forename: Ilandari Dewage Udara Anulal
authors.initials: ID
authors.lastname: Premachandra
authors.affiliation: Department of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
authors.forename: Stanley
authors.initials: S
authors.lastname: Hiew
authors.affiliation: Department of Biological Chemistry, University of California , Irvine, California 92697-1700, United States.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Scott
authors.affiliation: Department of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Oldenhuis
authors.affiliation: Department of Biological Chemistry, University of California , Irvine, California 92697-1700, United States.
authors.forename: Haoping
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
authors.forename: David L
authors.initials: DL
authors.lastname: Van Vranken
keywords: Candida albicans; antifungal agents; fluconazole; isoquinolone; phthalazinone; synergy