title: Neurotrophin Receptors and Perineural Invasion: Analyses in Select Lineage-Unrelated Cutaneous Malignancies With a Propensity for Perineural Invasion.
abstract: In this chapter, we parse the literature on neurotrophins that have been implicated in the pathogenesis of perineural invasion (PNI) in select lineage-unrelated malignancies. We also detail evidence linking neurotrophins and their receptors (TrkA, RET, p75NGFR, and NCAM) to the pathogenesis of PNI in desmoplastic melanoma and cutaneous squamous cell carcinoma-both malignancies with an established propensity for PNI. Lastly, the clinical potential of neurotrophins as receptors for targeted therapies is explored.
authors.affiliation: University of Iowa Carver College of Medicine, Iowa City, IA, United States.
authors.forename: N F
authors.initials: NF
authors.lastname: Frydenlund
authors.affiliation: VA Consolidated Laboratories, West Roxbury, MA, United States. Electronic address: me@meeramahalingam.com.
authors.forename: M
authors.initials: M
authors.lastname: Mahalingam
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008959:Models, Neurological; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000517:prevention & control; D009363:Neoplasm Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D009414:Nerve Growth Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D010525:Peripheral Nerves / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D017475:Receptors, Nerve Growth Factor / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000378:metabolism; D012583:Schwann Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D015507:Drugs, Investigational; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor
keywords: Cutaneous malignancies; GDNF–RET axis; NGF–TrkA axis; Perineural invasion