title: Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen.
abstract: Mixed hepatitis C virus (HCV) genotype infection is emerging with improved methods of detection. It is commonly seen in hemodialysis patients and intravenous drug users due to repeated HCV exposure and absence of protective immunity, and can contribute to treatment failure. Direct-acting antiviral regimens have been extensively studied in patients with different individual HCV genotypes; however, there are no reported data on their use in patients with mixed HCV genotype. We present a case of mixed HCV genotype 1a and 2 infection in a decompensated cirrhotic patient treated successfully with sofosbuvir, ledipasvir, and ribavirin.
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA; Tropical Medicine, Menoufia University Faculty of Medicine, Shebin El-Kom, Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: Ahmed Sakr
authors.affiliation: Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA.
authors.forename: Jasmine M
authors.initials: JM
authors.lastname: Hanifi
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
authors.forename: Ming
authors.initials: M
authors.lastname: Valerie Lin