title: The Impact of Therapeutic Antibodies on the Management of Digestive Diseases: History, Current Practice, and Future Directions.
abstract: The development of therapeutic antibodies represents a revolutionary change in medical therapy for digestive diseases. Beginning with the initial studies that confirmed the pathogenicity of cytokines in inflammatory bowel disease, the development and application of therapeutic antibodies brought challenges and insights into their potential and optimal use. Infliximab was the first biological drug approved for use in Crohn's disease and ulcerative colitis. The lessons learned from infliximab include the importance of immunogenicity and the influence of pharmacokinetics on disease response and outcomes. Building on this foundation, other therapeutic antibodies achieved approval for inflammatory bowel disease and many more are in development for several digestive diseases. In this review, we reflect on the history of therapeutic antibodies and discuss current practice and future directions for the field.
authors.affiliation: Inflammatory Bowel Disease Center, University of Chicago Medicine, 5841 South Maryland Avenue, MC 4076, Chicago, IL, 60637, USA. masofia@uchicago.edu.
authors.forename: M Anthony
authors.initials: MA
authors.lastname: Sofia
authors.affiliation: Inflammatory Bowel Disease Center, University of Chicago Medicine, 5841 South Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Rubin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D001688:Biological Products / Q000276:immunology / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D004066:Digestive System Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D019468:Disease Management; D005544:Forecasting; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D000069285:Infliximab / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D001688:Biological Products; D000069285:Infliximab
keywords: Adalimumab; Inflammatory bowel disease; Infliximab; Therapeutic antibodies; Therapeutic drug monitoring; Tumor necrosis factor alpha