title: Simultaneous Cyclization and Derivatization of Peptides Using Cyclopentenediones.
abstract: Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reaction times using only a slight excess of the cyclopentenedione moiety under TEMPO catalysis and in the presence of LiCl.
authors.forename: Omar
authors.initials: O
authors.lastname: Brun
authors.affiliation: University of Glasgow , Glasgow G12 8QQ, Scotland, United Kingdom.
authors.forename: Lewis J
authors.initials: LJ
authors.lastname: Archibald
authors.forename: Jordi
authors.initials: J
authors.lastname: Agramunt
authors.forename: Enrique
authors.identifier: 0000-0001-8171-3608
authors.initials: E
authors.lastname: Pedroso
authors.forename: Anna
authors.identifier: 0000-0001-6517-4018
authors.initials: A
authors.lastname: Grandas
mesh_terms: D003500:Cyclization; D003545:Cysteine; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
chemical_list: D010455:Peptides; D003545:Cysteine