title: The effect of iron nanoparticles on performance of cognitive tasks in rats.
abstract: To assess the influence of 62.5 ± 0.6 nm iron nanoparticles on the status of central nervous system, a study was conducted on Wistar rats, which were subjected to abdominal injection of the studied nanoparticles at doses of 2 and 14 mg/kg. Based on the analysis of the structural and functional status of the cerebral cortex of rats, behavioral reactions of animals, and the elemental composition of the cerebral cortex, we investigated the nanoparticles' neurotoxic effect, whose degree and nature varied depending on the dosage and the time elapsed after the injection. We identified pathological changes in motor and somatosensory areas of the rats' cerebral cortex and established pronounced changes in the elemental homeostasis of the animals' cerebral cortex in experimental groups. Identified structural changes were accompanied by an increase in exploratory activity, locomotor activity, and emotional status of the animals. At that, these activities were more pronounced in rats, which were administered iron nanoparticles at a dose of 14 mg/kg. By the end of the experiment, the excitation processes prevailed over the inhibition processes that have led to the inhibition of central nervous system activity in experimental animals against the adaptation to stress in rats of the control group.
authors.affiliation: Orenburg State University, Orenburg, Russia. vniims.or@mail.ru.
authors.forename: Elena
authors.initials: E
authors.lastname: Sheida
authors.affiliation: Orenburg State University, Orenburg, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Sipailova
authors.affiliation: Federal State Budgetary Scientific Institution "All-Russian Research Institute of Beef Cattle Breeding", Orenburg, Russia.
authors.forename: Sergei
authors.initials: S
authors.lastname: Miroshnikov
authors.affiliation: Orenburg State University, Orenburg, Russia.|Federal State Budgetary Scientific Institution "All-Russian Research Institute of Beef Cattle Breeding", Orenburg, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Sizova
authors.affiliation: Orenburg State University, Orenburg, Russia.
authors.forename: Svyatoslav
authors.initials: S
authors.lastname: Lebedev
authors.affiliation: Orenburg State University, Orenburg, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Rusakova
authors.affiliation: Orenburg State University, Orenburg, Russia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Notova
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology; D003071:Cognition / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007501:Iron / Q000633:toxicity*; D008297:Male; D053768:Metal Nanoparticles / Q000633:toxicity*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007501:Iron
keywords: Chemical elements; Cognitive tasks; Cortex; Iron nanoparticles; Rats