title: Utilization of electron-donating α,β-unsaturated oximes: regioselective inverse 1,3-dipolar cycloaddition of nitrones.
abstract: The cycloaddition of nitrones with α,β-unsaturated carbonyl compounds (enones) afforded predominantly 4-acylisoxazolidines, whereas the cycloaddition of the corresponding oximes afforded 5-iminoisoxazolidines. This inverse regioselection is due to HOMO activation by the oxime functionality.
authors.affiliation: Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. tamura@ac.shoyaku.ac.jp.
authors.forename: Yoshimitsu
authors.identifier: http://orcid.org/0000-0002-2868-901X
authors.initials: Y
authors.lastname: Hashimoto
authors.affiliation: Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. tamura@ac.shoyaku.ac.jp.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ishiwata
authors.affiliation: Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. tamura@ac.shoyaku.ac.jp.
authors.forename: Soko
authors.initials: S
authors.lastname: Tachikawa
authors.affiliation: Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. tamura@ac.shoyaku.ac.jp.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Ban
authors.affiliation: Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. tamura@ac.shoyaku.ac.jp.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Morita
authors.affiliation: Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. tamura@ac.shoyaku.ac.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Tamura