title: Supramolecular hydrogel based on high-solid-content mPECT nanoparticles and cyclodextrins for local and sustained drug delivery.
abstract: A novel injectable and high-solid-content drug-loaded supramolecular hydrogel (PTX-mPECT NP/α-CDgel) was prepared by self-assembly of inclusion complexes based on PTX-loaded mPECT (methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-un-decanone)) nanoparticles (PTX-mPECT NPs) and α-cyclodextrin (α-CD). Paclitaxel (PTX) was chosen as a hydrophobic drug encapsulated into mPECT NPs. Then, gelation occurred when the aqueous solution of α-CD was added to the PTX-mPECT NPs aqueous dispersion within several seconds after stirring. Importantly, with the erosion of the hydrogel, PTX-loaded NPs could be released again and then PTX released further. Rheological studies showed that PTX-mPECT NP/α-CDgelwith good injectability underwent a shear-induced sol-gel transition. The results of in vitro drug-release studies demonstrated a sustained-release profile, and the cumulative release of PTX was ≈35% after 20 days. The results of cell-uptake studies and in vitro cytotoxicity studies indicated that the PTX-loaded NPs have been efficiently delivered to cells and killed tumor cells. Higher suppression of tumor growth demonstrated the remarkable anticancer effect of PTX-mPECT NP/α-CDgelupon peritumoral injection. These results showed that high-solid-content PTX-mPECT NP/α-CDgelbased on in situ systems could be a promising candidate for local and sustained drug delivery.
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, China. dengliandong@tju.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, China. dengliandong@tju.edu.cn.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, China. dengliandong@tju.edu.cn.
authors.forename: Zujian
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, China. dengliandong@tju.edu.cn.
authors.forename: Hongzhang
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, China. dengliandong@tju.edu.cn.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Tianjin Life Science Research Center and School of basic medical sciences Tianjin Medical University, Tianjin 300070, China. gaohuijie19860420@163.com.
authors.forename: Huijie
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, China. dengliandong@tju.edu.cn.
authors.forename: Liandong
authors.identifier: http://orcid.org/0000-0001-5906-236X
authors.initials: L
authors.lastname: Deng
authors.affiliation: Tianjin Life Science Research Center and School of basic medical sciences Tianjin Medical University, Tianjin 300070, China. gaohuijie19860420@163.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, China. dengliandong@tju.edu.cn.
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D002208:Caproates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007267:Injections; D007783:Lactones / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry*; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002208:Caproates; D003692:Delayed-Action Preparations; D007783:Lactones; D047391:alpha-Cyclodextrins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C121056:caprolactone; D017239:Paclitaxel