title: Cycloalkylation of C(sp3)-H Bond with Neighboring Carboxylic Acid as Traceless Activating Group.
abstract: Selective functionalization of inert C(sp3)-H bond is one of cutting-edge challenges in chemical synthesis. A novel strategy for selective C(sp3)-H bond cycloalkylation is developed with neighboring carboxylic acid as a traceless activating group. Primary and secondary alkyl carboxylic acids undergo decarboxylation/α-C(sp3)-H cleavage/cycloalkylation to give the five-membered cyclization products, while tertiary acids undergo decarboxylation/β-C(sp3)-H cleavage/cycloalkylation to generate the six-membered cyclization products.
authors.affiliation: Department of Chemistry, Renmin University of China , Beijing 100872, China.
authors.forename: Leiyang
authors.identifier: 0000-0002-2850-8952
authors.initials: L
authors.lastname: Lv
authors.affiliation: Department of Chemistry, Renmin University of China , Beijing 100872, China.
authors.forename: Zhiping
authors.identifier: 0000-0001-7987-279X
authors.initials: Z
authors.lastname: Li