title: 5-hydroxytryptamine1A receptor density in the hippocampus of patients with temporal lobe epilepsy is associated with disease duration.
abstract: To date, no study has evaluated the association between serotonin receptor density and clinical variables in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS) using hippocampal tissue. We evaluated 5-hydroxytryptamine1A receptor (5-HT1AR) density in hippocampal tissue from patients with TLE-HS.
  
  
  
  We analyzed the hippocampal tissue of 34 patients with pharmacoresistant unilateral TLE-HS. 5-HT1AR density was measured using semiquantitative western blotting.
  
  
  
  There was an association between higher density of 5-HT1AR and longer duration of epilepsy (Spearman correlation: P = 0.040; generalized linear model: P = 0.026).
  
  
  
  This study demonstrated that hippocampal 5-HT1AR density is associated with epilepsy duration in patients with TLE-HS. The authors postulate that this may represent a potential regulatory enhancement of endogenous serotonergic neurotransmission in response to prolonged and enduring epileptiform activity in the hippocampal tissue of patients with pharmacoresistant TLE-HS.
authors.affiliation: Institute and Department of Psychiatry, University of São Paulo, São Paulo.
authors.forename: N C
authors.identifier: 0000-0003-0148-5313
authors.initials: NC
authors.lastname: Fonseca
authors.affiliation: Laboratory of Neuroscience, Institute and Department of Psychiatry, Clinical Hospital, University of São Paulo, São Paulo.
authors.forename: H P G
authors.initials: HP
authors.lastname: Joaquim
authors.affiliation: Laboratory of Neuroscience, Institute and Department of Psychiatry, Clinical Hospital, University of São Paulo, São Paulo.
authors.forename: L L
authors.initials: LL
authors.lastname: Talib
authors.affiliation: Institute and Department of Psychiatry, University of São Paulo, São Paulo.|Laboratory of Neuroimaging, Institute and Department of Psychiatry, University of São Paulo, São Paulo, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Vincentiis
authors.affiliation: Laboratory of Neuroscience, Institute and Department of Psychiatry, Clinical Hospital, University of São Paulo, São Paulo.
authors.forename: W F
authors.initials: WF
authors.lastname: Gattaz
authors.affiliation: Institute and Department of Psychiatry, University of São Paulo, São Paulo.|Laboratory of Neuroimaging, Institute and Department of Psychiatry, University of São Paulo, São Paulo, Brazil.
authors.forename: K D
authors.initials: KD
authors.lastname: Valente
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D012598:Sclerosis / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D055815:Young Adult
chemical_list: D044282:Receptor, Serotonin, 5-HT1A
keywords: epilepsy surgery; hippocampal sclerosis; hippocampus; refractory; serotonin; western blotting