title: Mechanistic Debris Generated by Twister Ribozymes.
abstract: Twister RNAs represent a recently discovered class of natural ribozymes that promote rapid cleaving of RNA backbones. Although an abundance of theoretical, biochemical, and structural data exist for several members of the twister class, disagreements about the architecture and mechanism of its active site have emerged. Historically, such storms regarding mechanistic details typically occur soon after each new self-cleaving ribozyme class is reported, but paths forward exist to quickly reach calmer conditions.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, ‡Department of Molecular Biophysics and Biochemistry, §Howard Hughes Medical Institute, Yale University , New Haven, Connecticut 06520, United States.
authors.forename: Ronald R
authors.identifier: 0000-0002-2165-536X
authors.initials: RR
authors.lastname: Breaker
mesh_terms: D002384:Catalysis; D009690:Nucleic Acid Conformation; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism*
chemical_list: D016337:RNA, Catalytic