title: Predictors of long-term functional outcome and health-related quality of life after out-of-hospital cardiac arrest.
abstract: Even if a large majority of out-of-hospital cardiac arrest (OHCA) survivors appear to have a good neurological recovery with no important sequellae, whether health-related quality of life (HRQOL) is altered is less explored.
  
  
  
  HRQOL was evaluated by telephone interview using SF-36 questionnaire. Each OHCA case was age and gender-matched with 4 controls from the French general population. Association between current condition of the survivors with the 8 dimensions of the SF-36 questionnaire was investigated using MANCOVA. Cluster analysis was performed to identify patterns of HRQOL among CPC1 survivors.
  
  
  
  255 patients discharged alive from our referral centre between 2000 and 2013 (median age of 55y [45,64], 73.7% males) were interviewed. Global physical and mental components did not differ between CPC 1 survivors and controls (47.0 vs. 47.1, p=0.88 and 46.4 vs. 46.9, p=0.45) but substantially differed between CPC2, CPC3 and the corresponding controls. Younger age, male gender, good neurological recovery and daily-life autonomy at telephone interview were significantly associated with better scores in each SF-36 dimensions. Cluster analysis individualized 4 distinct subgroups of CPC1 patients characterised by progressively increased score of SF-36. Return to work and daily-life autonomy were differently distributed across these 4 groups while pre-hospital Utstein variables were not.
  
  
  
  HRQOL of CPC1 OHCA survivors appeared similar to that of the general population, but patients with CPC2 or 3 had altered HRQOL. Younger age, male gender, good neurological recovery and daily-life autonomy were independently associated with a better HRQOL.
authors.affiliation: Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Geri
authors.affiliation: Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France; Emergency Department, Cochin Hospital, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Dumas
authors.affiliation: Methodological and Quality of Life Unit in Oncology (EA3181) - University Hospital of Besançon, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Bonnetain
authors.affiliation: Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France.
authors.forename: Wulfran
authors.initials: W
authors.lastname: Bougouin
authors.affiliation: Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Champigneulle
authors.affiliation: Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Arnaout
authors.affiliation: Sudden Death Expertise Centre, Paris, France; SAMU 75, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Carli
authors.affiliation: Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France; Cardiology Department, Pompidou Hospital, APHP, Paris, France.
authors.forename: Eloi
authors.initials: E
authors.lastname: Marijon
authors.affiliation: Université Paris-Descartes, Paris, France; Cardiology Department, Cochin Hospital, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Varenne
authors.affiliation: Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Mira
authors.affiliation: Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Empana
authors.affiliation: Medical ICU, Cochin Hospital, APHP, Paris, France; Université Paris-Descartes, Paris, France; Sudden Death Expertise Centre, Paris, France. Electronic address: alain.cariou@aphp.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Cariou
mesh_terms: D000328:Adult; D000367:Age Factors; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects / Q000379:methods; D016000:Cluster Analysis; D005260:Female; D005602:France / Q000453:epidemiology; D054624:Health Status Disparities; D006801:Humans; D007407:Interviews as Topic; D000069451:Long Term Adverse Effects / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000453:epidemiology / Q000534:rehabilitation / Q000628:therapy; D011788:Quality of Life; D020127:Recovery of Function; D012737:Sex Factors; D017741:Survivors / Q000523:psychology
keywords: Health-related quality of life; Neurologic outcome; Out-of-hospital cardiac arrest