title: Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence.
abstract: Cancer cells with stem-like properties are believed to contribute to treatment resistance, dissemination, and recurrence. SOX9 controls stem cell plasticity and its deregulation may provide a basis for tumor progression. Here, we summarize our findings of targeted SOX9 destruction by SCFFBW7(Skp1/Cul1/F-box) in medulloblastoma and its potential for therapeutic intervention.
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute , Stockholm, Sweden.
authors.forename: Aldwin
authors.identifier: 0000-0002-4593-286X
authors.initials: A
authors.lastname: Suryo Rahmanto
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden.
authors.forename: Fredrik J
authors.identifier: 0000-0002-8460-4367
authors.initials: FJ
authors.lastname: Swartling
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute , Stockholm, Sweden.
authors.forename: Olle
authors.identifier: 0000-0002-0316-0195
authors.initials: O
authors.lastname: Sangfelt
keywords: Drug resistance; FBW7; SCF ubiquitin ligase; SOX9; medulloblastoma; metastasis