title: Cell death: From initial concepts to pathways to clinical applications - Personal reflections of a clinical researcher.
abstract: Cell death research has come a long way from the description of cellular phenomena to identification of pathways to the role of apoptosis in tissue homeostasis in the pathophysiology of diseases and the delineation of targets for therapeutic intervention. In this very personal view of a clinical researcher in the field from the very beginning to recent clinical application, essential elements of cell death research over the past decades are seen from a perspective of development of science and medicine.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Eythstr. 24, 89075 Ulm, Germany. Electronic address: klaus-michael.debatin@uniklinik-ulm.de.
authors.forename: Klaus-Michael
authors.initials: KM
authors.lastname: Debatin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016923:Cell Death / Q000502:physiology*; D005858:Germany; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015398:Signal Transduction; D057170:Translational Research, Biomedical / Q000266:history
keywords: Apoptosis; CD95 (APO-1); Cell Death; IAPs