title: High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes.
abstract: Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area.
  
  
  
  We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were followed up for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA). Outcomes were the development of celiac disease autoimmunity (CDA) or celiac disease. CDA was defined as persistence of tTGA for at least 3 months or development of celiac disease. Celiac disease was defined based on detection of Marsh 2 or greater lesions in biopsy specimens or persistent high levels of tTGA. For each genotype, the cumulative incidence of CDA and celiac disease were determined. To estimate the cumulative incidence in the Denver general population, outcomes by each genotype were weighted according to the frequency of each of these genotypes in the general population.
  
  
  
  Of 1339 subjects followed up, 66 developed CDA and met criteria for celiac disease and 46 developed only CDA. Seropositivity for tTGA resolved spontaneously, without treatment, in 21 of the 46 subjects with only CDA (46%). The estimated cumulative incidence for CDA in the Denver general population at 5, 10, and 15 years of age was 2.4%, 4.3%, and 5.1%, respectively, and incidence values for celiac disease were 1.6%, 2.8%, and 3.1%, respectively.
  
  
  
  In a 20-year prospective study of 1339 children with genetic risk factors for celiac disease, we found the cumulative incidence of CDA and celiac disease to be high within the first 10 years. Although more than 5% of children may experience a period of CDA, not all children develop celiac disease or require gluten-free diets.
authors.affiliation: Digestive Health Institute and Colorado Center for Celiac Disease, Children's Hospital Colorado, University of Colorado Denver, Aurora, Colorado; Barbara Davis Center, University of Colorado Denver, Aurora, Colorado. Electronic address: edwin.liu@childrenscolorado.org.
authors.forename: Edwin
authors.initials: E
authors.lastname: Liu
authors.affiliation: Barbara Davis Center, University of Colorado Denver, Aurora, Colorado.
authors.forename: Fran
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado.
authors.forename: Anna E
authors.initials: AE
authors.lastname: Barón
authors.affiliation: Barbara Davis Center, University of Colorado Denver, Aurora, Colorado.
authors.forename: Iman
authors.initials: I
authors.lastname: Taki
authors.affiliation: Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Norris
authors.affiliation: Barbara Davis Center, University of Colorado Denver, Aurora, Colorado.
authors.forename: Brigitte I
authors.initials: BI
authors.lastname: Frohnert
authors.affiliation: Digestive Health Institute and Colorado Center for Celiac Disease, Children's Hospital Colorado, University of Colorado Denver, Aurora, Colorado.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Hoffenberg
authors.affiliation: Barbara Davis Center, University of Colorado Denver, Aurora, Colorado.
authors.forename: Marian
authors.initials: M
authors.lastname: Rewers
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D002446:Celiac Disease / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003120:Colorado / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D019204:GTP-Binding Proteins / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012307:Risk Factors; D013997:Time Factors; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins
keywords: DR3-DQ2; DR4-DQ8; Disease Progression; Transglutaminase