title: Birth size, risk factors across life and cognition in late life: protocol of prospective longitudinal follow-up of the MYNAH (MYsore studies of Natal effects on Ageing and Health) cohort.
abstract: For late-life neurocognitive disorders, as for other late-life chronic diseases, much recent interest has focused on the possible relevance of Developmental Origins of Health and Disease (DOHaD). Programming by undernutrition in utero, followed by overnutrition in adult life may lead to an increased risk, possibly mediated through cardiovascular and metabolic pathways. This study will specifically examine, if lower birth weight is associated with poorer cognitive functioning in late life in a south Indian population.
  
  
  
  From 1934 onwards, the birth weight, length and head circumference of all babies born in the CSI Holdsworth Memorial Hospital, Mysore, India, were recorded in obstetric notes. Approximately 800 men and women from the Mysore Birth Records Cohort aged above 55 years, and a reliable informant for each, will be asked to participate in a single cross-sectional baseline assessment for cognitive function, mental health and cardiometabolic disorders. Participants will be assessed for hypertension, type-2 diabetes and coronary heart disease, nutritional status, health behaviours and lifestyles, family living arrangements, economic status, social support and social networks. Additional investigations include blood tests (for diabetes, insulin resistance, dyslipidaemia, anaemia, vitamin B12and folate deficiency, hyperhomocysteinemia, renal impairment, thyroid disease and Apolipoprotein E genotype), anthropometry, ECG, blood pressure, spirometry and body composition (bioimpedance). We will develop an analysis plan, first using traditional univariate and multivariable analytical paradigms with independent, dependent and mediating/confounding/interacting variables to test the main hypotheses.
  
  
  
  This study has been approved by the research ethics committee of CSI Holdsworth Memorial Hospital. The findings will be disseminated locally and at international meetings, and will be published in open access peer reviewed journals.
authors.affiliation: Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India.
authors.forename: Murali
authors.initials: M
authors.lastname: Krishna
authors.affiliation: Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India.
authors.forename: G Mohan
authors.initials: GM
authors.lastname: Kumar
authors.affiliation: Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India.
authors.forename: S R
authors.initials: SR
authors.lastname: Veena
authors.affiliation: Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India.
authors.forename: G V
authors.initials: GV
authors.lastname: Krishnaveni
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
authors.forename: Kalyanaraman
authors.initials: K
authors.lastname: Kumaran
authors.affiliation: Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India.
authors.forename: Samuel Christaprasad
authors.initials: SC
authors.lastname: Karat
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
authors.forename: Patsy
authors.initials: P
authors.lastname: Coakley
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
authors.forename: Clive
authors.initials: C
authors.lastname: Osmond
authors.affiliation: Department of Psychiatry, University of Liverpool, Liverpool, UK.
authors.forename: John R M
authors.initials: JR
authors.lastname: Copeland
authors.affiliation: Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India.
authors.forename: Giriraj
authors.initials: G
authors.lastname: Chandak
authors.affiliation: Diabetic Unit, KEM Hospital, Pune, Maharashtra, India.
authors.forename: Dattatray
authors.initials: D
authors.lastname: Bhat
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
authors.forename: Mathew
authors.initials: M
authors.lastname: Varghese
authors.affiliation: Institute of Psychiatry, De Crespigny Park, Kings College, London, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Prince
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: Fall
mesh_terms: D053327:Apolipoprotein E4 / Q000235:genetics; D001724:Birth Weight; D001827:Body Height; D003071:Cognition; D003072:Cognition Disorders / Q000453:epidemiology* / Q000235:genetics; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006257:Head / Q000033:anatomy & histology*; D006801:Humans; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4
keywords: Cognition; Late life; birth weight; fetal growth; programming