title: Safety assessment of medium- and long-chain triacylglycerols containing 30% (w/w) medium-chain fatty acids in mice and rats.
abstract: A novel medium- and long-chain triacylglycerols (MLCT), with 30% (w/w) medium-chain fatty acids (MCFA) was evaluated for its safety as a dietary fat in mice and rats. The subacute oral toxicity study showed that the maximum tolerated dose exceeded 54.33 g/kg body weight (kg bw)/day. In the 90-day feeding study, no dose-related adverse effects were observed in rats administered diets formulated with different levels of MLCT (2.0, 4.0, and 8.0 g/kg bw/day) as compared to the rapeseed oil control diet. Further safety assessment in pregnant rats did not reveal any significant difference relative to the control at a treatment level up to 8.0 g MLCT/kg bw/day. The results from this study indicated the safe use of MLCT with high contents of MCFA in food products for improving human health.
authors.affiliation: Institute of Food and Nutraceutical Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Shengmin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd, Shanghai, 200137, China.
authors.forename: Yueqiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd, Shanghai, 200137, China.
authors.forename: Yuanrong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, United States. Electronic address: lyu5@umd.edu.
authors.forename: Liangli Lucy
authors.initials: LL
authors.lastname: Yu
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000633:toxicity*; D005227:Fatty Acids / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D000074262:Rapeseed Oil / Q000633:toxicity; D051381:Rats; D014280:Triglycerides / Q000737:chemistry / Q000633:toxicity*
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D000074262:Rapeseed Oil; D014280:Triglycerides
keywords: 90-Day feeding study; Embryotoxicity study in pregnant rats; Medium- and long-chain triacylglycerols; Safety assessment; Subacute oral toxicity study