title: Disseminated tuberculosis in a newborn infant.
abstract: Tuberculosis (TB) remaining as one of the deadliest communicable diseases. Congenital infection by vertical transmission is rare but high neonatal mortality (up to 60%) and morbidity warrant early and accurate diagnosis of newborns suffering from TB. Intrauterine infection of tuberculosis is most commonly caused by haematogenous spread from the mother causing placental seedling. The organisms reach the fetus via the umbilical vein and the primary focus is often in the fetal liver in hematgenous spread. Another route of infection is by direct ingestion or aspiration of infected amniotic fluid if the placental caseous lesion ruptures directly into the amniotic cavity. Transplacental infection occurs late in pregnancy and aspiration from amniotic fluid occurs in the perinatal period. We report here one case of disseminated tuberculosis in a new born infant.
authors.affiliation: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Tanu
authors.initials: T
authors.lastname: Sagar
authors.affiliation: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Kavita
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Mayuri
authors.initials: M
authors.lastname: Rani
authors.affiliation: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Iqbal Rajinder
authors.initials: IR
authors.lastname: Kaur
keywords: Congenital tuberculosis; diagnosis; management; transmission