title: Host Materials Transformable in Tumor Microenvironment for Homing Theranostics.
abstract: A pathology-adaptive nanosystem, in which nest-like hosts are built based on nanofibers that are transformed from i.v. injected nanoparticles under the acidic tumor microenvironment. The solid tumor is artificially modified by nest-like hosts readily and firmly, resulting in highly efficient accumulation and stabilization of guest theranostics. This strategy shows great potential for the theranostics delivery to tumors.
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Yang
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.|Faculty of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Luo
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Guo-Bin
authors.initials: GB
authors.lastname: Qi
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Yu-Juan
authors.initials: YJ
authors.lastname: Gao
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.|Faculty of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Li
authors.affiliation: Faculty of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Zhang
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
mesh_terms: D006801:Humans; D057139:Nanofibers; D053758:Nanoparticles; D009369:Neoplasms; D000068936:Theranostic Nanomedicine; D059016:Tumor Microenvironment
keywords: cancer; morphology; peptides; self-assembly; theranostics