title: [Saccharomyces cerevisiae invasive infection: The first reported case in Morocco].
abstract: Saccharomyces cerevisiae is a cosmopolitan yeast, widely used in agro-alimentary and pharmaceutical industry. Its impact in human pathology is rare, but maybe still underestimated compared to the real situation. This yeast is currently considered as an emerging and opportunistic pathogen. Risk factors are immunosuppression and intravascular device carrying. Fungemias are the most frequent clinical forms. We report the first case of S. cerevisiae invasive infection described in Morocco, and to propose a review of the literature cases of S. cerevisiae infections described worldwide. A 77-year-old patient, with no notable medical history, who was hospitalized for a upper gastrointestinal stenosis secondary to impassable metastatic gastric tumor. Its history was marked by the onset of septic shock, with S. cerevisiae in his urine and in his blood, with arguments for confirmation of invasion: the presence of several risk factors in the patient, positive direct microbiological examination, abundant and exclusive culture of S. cerevisiae from clinical samples. Species identification was confirmed by the study of biochemical characteristics of the isolated yeast. Confirmation of S. cerevisiae infection requires a clinical suspicion in patients with risk factors, but also a correct microbiological diagnosis.
authors.affiliation: Laboratoire de microbiologie, centre hospitalier universitaire Mohammed VI d'Oujda, BP 4806, 60049 Oujda, Maroc; Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Maleb
authors.affiliation: Laboratoire de microbiologie, centre hospitalier universitaire Mohammed VI d'Oujda, BP 4806, 60049 Oujda, Maroc; Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc. Electronic address: sebbarelhoucine@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Sebbar
authors.affiliation: Service de bactériologie, hôpital militaire d'instruction Mohammed V de Rabat, Oujda, Maroc; Faculté de médecine et de pharmacie, université Mohammed V de Rabat, Oujda, Maroc.
authors.forename: M
authors.initials: M
authors.lastname: Frikh
authors.affiliation: Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc; Service d'hépato-gastro-entérologie, centre hospitalier universitaire Mohammed VI d'Oujda, Oujda, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Boubker
authors.affiliation: Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc; Service d'hépato-gastro-entérologie, centre hospitalier universitaire Mohammed VI d'Oujda, Oujda, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Moussaoui
authors.affiliation: Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc; Service d'hépato-gastro-entérologie, centre hospitalier universitaire Mohammed VI d'Oujda, Oujda, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: El Mekkaoui
authors.affiliation: Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc; Service d'hépato-gastro-entérologie, centre hospitalier universitaire Mohammed VI d'Oujda, Oujda, Maroc.
authors.forename: W
authors.initials: W
authors.lastname: Khannoussi
authors.affiliation: Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc; Service d'hépato-gastro-entérologie, centre hospitalier universitaire Mohammed VI d'Oujda, Oujda, Maroc.
authors.forename: G
authors.initials: G
authors.lastname: Kharrasse
authors.affiliation: Service de bactériologie, hôpital militaire d'instruction Mohammed V de Rabat, Oujda, Maroc; Faculté de médecine et de pharmacie, université Mohammed V de Rabat, Oujda, Maroc.
authors.forename: B
authors.initials: B
authors.lastname: Belefquih
authors.affiliation: Service de bactériologie, hôpital militaire d'instruction Mohammed V de Rabat, Oujda, Maroc; Faculté de médecine et de pharmacie, université Mohammed V de Rabat, Oujda, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Lemnouer
authors.affiliation: Faculté de médecine et de pharmacie, université Mohammed Premier d'Oujda, Oujda, Maroc; Service d'hépato-gastro-entérologie, centre hospitalier universitaire Mohammed VI d'Oujda, Oujda, Maroc.
authors.forename: Z
authors.initials: Z
authors.lastname: Ismaili
authors.affiliation: Service de bactériologie, hôpital militaire d'instruction Mohammed V de Rabat, Oujda, Maroc; Faculté de médecine et de pharmacie, université Mohammed V de Rabat, Oujda, Maroc.
authors.forename: M
authors.initials: M
authors.lastname: Elouennass
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D000072742:Invasive Fungal Infections / Q000382:microbiology / Q000473:pathology*; D008297:Male; D009018:Morocco; D009181:Mycoses / Q000382:microbiology* / Q000473:pathology*; D012441:Saccharomyces cerevisiae / Q000302:isolation & purification / Q000472:pathogenicity
keywords: Fongémie; Fungemia; Infections opportunistes; Infections urinaires; Opportunistic infections; Saccharomyces cerevisiae; Urinary tract infections