title: Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea.
abstract: Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement of cell replacement therapies for hearing loss. Transcription factor Atoh1 is the key player during HC development and regeneration. In this review, we will focus on Atoh1 and its related signaling pathways (Notch, fibroblast growth factor, and Wnt/β-catenin signaling) involved in the development of cochlear sensory HCs. We will also discuss the potential applicability of these signals for the induction of HC regeneration.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.; Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea.
authors.forename: Sungsu
authors.initials: S
authors.lastname: Lee
authors.affiliation: Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea.; Department of Physiology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Han-Seong
authors.initials: HS
authors.lastname: Jeong
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.; Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea.
authors.forename: Hyong-Ho
authors.initials: HH
authors.lastname: Cho
keywords: Hair Cells, Auditory; Hearing Loss; Regeneration; Transcription Factors