title: Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine strain in children.
abstract: This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. A genotype analysis of ORF 22 amino acids revealed genotype J in all children except one. Genotype E was identified in an infant with varicella imported from Egypt.
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.|Department of Microbiology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Byung Ok
authors.identifier: http://orcid.org/0000-0001-5527-0794
authors.initials: BO
authors.lastname: Kwak
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.|Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hoan Jong
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.|Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyun Mi
authors.initials: HM
authors.lastname: Kang
authors.affiliation: Department of Pediatrics, Kosin University College of Medicine, Busan, Korea.
authors.forename: Chi Eun
authors.initials: CE
authors.lastname: Oh
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea. eunchoi@snu.ac.kr.|Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. eunchoi@snu.ac.kr.
authors.forename: Eun Hwa
authors.initials: EH
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006562:Herpes Zoster / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016366:Open Reading Frames; D066106:Seoul; D014611:Vaccination; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology; D055815:Young Adult
chemical_list: D014764:Viral Proteins; D014765:Viral Vaccines
keywords: Children; Genotype; Varicella-zoster virus