title: Single Nanochannel Platform for Detecting Chiral Drugs.
abstract: Chiral drugs play an essential role in medical and biochemical systems, and thus enantioselective analysis of chiral molecules has become a central focus in chemical, biological, medical, and pharmaceutical research. The design of chiral drug-detecting systems is a long-term and challenging task. Here we report the use of a modification-free nanochannel method for enantioselective recognition of S-naproxen from R-naproxen using N-acetyl-l-cysteine-capped gold nanoparticles as a chiral selector. The chiral discrimination is based on a drug-induced nanoparticle diastereoselective aggregation mechanism that blocks ion transport through the nanochannel. We demonstrated that high S-Npx selectivity in both water and biological samples can be achieved. This simple method has potential applications as a general platform for the detection of chiral molecules.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Imene
authors.initials: I
authors.lastname: Boussouar
authors.affiliation: Department of Chemistry, University of Utah , 315 S, 1400 E, Salt Lake City, Utah 84112, United States.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of Utah , 315 S, 1400 E, Salt Lake City, Utah 84112, United States.
authors.forename: Yulun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Demei
authors.initials: D
authors.lastname: Tian
authors.affiliation: Department of Chemistry, University of Utah , 315 S, 1400 E, Salt Lake City, Utah 84112, United States.
authors.forename: Henry S
authors.identifier: 0000-0002-5053-0996
authors.initials: HS
authors.lastname: White
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Haibing
authors.identifier: 0000-0002-6374-4694
authors.initials: H
authors.lastname: Li
mesh_terms: D000111:Acetylcysteine / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification; D019281:Dimerization; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation; D009288:Naproxen / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen; D006046:Gold; D000111:Acetylcysteine