title: NK/T Cell Lymphoma: A Tertiary Centre Experience.
abstract: Extranodal NK/T-cell lymphoma (ENKTL), nasal type, is a rare type of non-Hodgkin lymphoma that is commonly seen in East Asian countries and is associated with Epstein-Barr virus infection. This is a retrospective study where we describe nine cases of ENKTL; nasal type diagnosed and treated at our center over a period of 2 years. These cases were analyzed retrospectively for clinical presentation (age, sex, site of involvement), immunophenotype, treatment, response and toxicity profile. Sino-nasal symptoms (blocked nose, headache, epistaxis, regurgitation) were the most common presenting complaints (n = 8). Almost 67 % (n = 6/9) of the cases were referred from Bhutan. Necrosis and angiocentricity were the commonest histological features. Depending on the stage of the disease patient were initially treated with chemotherapy (SMILE/CHOP) and Radiotherapy (IFRT). We describe our experience of management of ENKTL, where we observe that Bhutan could be endemic region for this rare tumour.
authors.affiliation: Department of Laboratory Haematology & Molecular Genetics, Tata Medical Center, Kolkata, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Arora
authors.affiliation: Department of Laboratory Haematology & Molecular Genetics, Tata Medical Center, Kolkata, India.
authors.forename: Arpan
authors.initials: A
authors.lastname: Mehta
authors.affiliation: Department of Clinical Haematology, Tata Medical Center, Kolkata, India.
authors.forename: Sriram
authors.initials: S
authors.lastname: Ravichandran
authors.affiliation: Department of Pathology, Tata Medical Center, Kolkata, India.
authors.forename: Indu
authors.initials: I
authors.lastname: Arun
authors.affiliation: Department of Radiation Oncology, Tata Medical Center, Kolkata, India.
authors.forename: Rimpa Basu
authors.initials: RB
authors.lastname: Achari
authors.affiliation: Department of Clinical Haematology, Tata Medical Center, Kolkata, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Chakrapani
authors.affiliation: Department of Clinical Haematology, Tata Medical Center, Kolkata, India.
authors.forename: Saurabh Jayant
authors.initials: SJ
authors.lastname: Bhave
authors.affiliation: Department of Clinical Haematology, Tata Medical Center, Kolkata, India.
authors.forename: Mammen
authors.initials: M
authors.lastname: Chandy
authors.affiliation: Department of Clinical Haematology, Tata Medical Center, Kolkata, India.
authors.forename: Reena
authors.initials: R
authors.lastname: Nair
keywords: NK/T cell lymphoma; SMILE in NK/T cell lymphoma; SMILE therapy; T-cell lymphomas in India