title: Splenic Hamartoma: Immunohistochemical Profile.
abstract: Splenic hamartoma is an unusual accidental finding with non-neoplastic feature that may be incidentally diagnosed because of its compression effect on surrounding organs. The predominant pathological feature leading diagnosis is circumscribed, un-encapsulated bulging nodules with focal fibrosis or cyst. The histopathological feature of splenic hamartoma is the positivity for CD8, and occasionally for CD31, CD34, and CD68 biomarkers on vascular wall but the cells are frequently negative for CD21. Herein, we describe a case with initial diagnosis of nephrolithiasis due to abdominal pain that was finally confirmed as splenic hamartoma by histopathological assessments and detection of CD8, CD31, CD34, and CD68 positivity.
authors.affiliation: Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Tavangar
authors.affiliation: Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Abdollahi
mesh_terms: D015415:Biomarkers; D003560:Cysts / Q000175:diagnosis; D003937:Diagnosis, Differential; D006222:Hamartoma / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013158:Splenic Diseases / Q000175:diagnosis*
chemical_list: D015415:Biomarkers
keywords: Immunohistochemistry; Splenic hamartoma