title: MBV: a method to solve sample mislabeling and detect technical bias in large combined genotype and sequencing assay datasets.
abstract: BACKGROUND
  Large genomic datasets combining genotype and sequence data, such as for expression quantitative trait loci (eQTL) detection, require perfect matching between both data types.
  
  
  RESULTS
  We described here MBV (Match BAM to VCF); a method to quickly solve sample mislabeling and detect cross-sample contamination and PCR amplification bias.
  
  
  METHODS
  MBV is implemented in C ++ as an independent component of the QTLtools software package, the binary and source codes are freely available at https://qtltools.github.io/qtltools/ .
  
  
  BACKGROUND
  olivier.delaneau@unige.ch or emmanouil.dermitzakis@unige.ch.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Fort
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.|Swiss Institute of Bioinformatics, Lausanne, Switzerland.|Institute of Genetics and Genomics in Geneva, Geneva, Switzerland.
authors.forename: Nikolaos I
authors.initials: NI
authors.lastname: Panousis
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.|Swiss Institute of Bioinformatics, Lausanne, Switzerland.|Institute of Genetics and Genomics in Geneva, Geneva, Switzerland.
authors.forename: Marco
authors.initials: M
authors.lastname: Garieri
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.|Institute of Genetics and Genomics in Geneva, Geneva, Switzerland.
authors.forename: Stylianos E
authors.initials: SE
authors.lastname: Antonarakis
authors.affiliation: New York Genome Center, New York, USA.|Department of Systems Biology, Columbia University, New York, USA.
authors.forename: Tuuli
authors.initials: T
authors.lastname: Lappalainen
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.|Swiss Institute of Bioinformatics, Lausanne, Switzerland.|Institute of Genetics and Genomics in Geneva, Geneva, Switzerland.
authors.forename: Emmanouil T
authors.initials: ET
authors.lastname: Dermitzakis
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.|Swiss Institute of Bioinformatics, Lausanne, Switzerland.|Institute of Genetics and Genomics in Geneva, Geneva, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Delaneau
mesh_terms: D015982:Bias; D023281:Genomics / Q000379:methods / Q000592:standards; D060005:Genotyping Techniques / Q000379:methods* / Q000592:standards; D006801:Humans; D040641:Quantitative Trait Loci; D017422:Sequence Analysis, DNA / Q000379:methods* / Q000592:standards; D012984:Software