title: TRPM2: a potential drug target to retard oxidative stress.
abstract: TheTransientReceptorPotentialMelastatin 2 (TRPM2) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both ion channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. TRPM2 is involved in Ca2+signaling in various cells as an endogenous redox sensor for oxidative stress and reactive oxygen species, and contributes to cytokine production, insulin release, motility, Ca2+entry and Ca2+-dependent cellular reactions such as endothelial hyper-permeability and apoptosis. The wide expression of TRPM2 might render it as a potentially significant therapeutic target in pathological settings including cardiovascular and neurodegenerative diseases and of great relevance in drug design, feed additives and other industries. Here, we discuss the TRPM2 gene structure, function, its variants, as well as its activators and inhibitors and provide a peptide drug design for modulation of oxidative stress.
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Changsha, Hunan 410125, Peoples R China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Xiangyang Central Hospital, the Affliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, Peoples R China.
authors.forename: Yunling
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Changsha, Hunan 410125, Peoples R China.
authors.forename: Xianying
authors.initials: X
authors.lastname: Bao
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Changsha, Hunan 410125, Peoples R China.
authors.forename: Fengna
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, Tianjin Medial University, Tianjin 300052, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yao
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Changsha, Hunan 410125, Peoples R China, zemengfeng2006@163.com.
authors.forename: Zemeng
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Changsha, Hunan 410125, Peoples R China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D020013:Calcium Signaling; D055808:Drug Discovery; D014644:Genetic Variation; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D050053:TRPM Cation Channels / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000235:genetics; D014018:Tissue Distribution
chemical_list: D017382:Reactive Oxygen Species; D050053:TRPM Cation Channels; C121934:TRPM2 protein, human