title: Survey of patient and partner satisfaction following collagenase Clostridium histolyticum treatment for Peyronie's disease.
abstract: Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Patients and their FSPs were subsequently contacted by telephone and queried regarding their ability to have intercourse and their satisfaction with treatment. A total of 24 couples responded to our questionnaire and constitute the subjects of this analysis. Patient and FSP satisfaction with treatment were 67% and 71%, respectively. Significant predictors of FSP satisfaction with treatment included recall of penile trauma during prior sexual intercourse, improved ability to have sexual intercourse following treatment, and absence of post-procedural glans hypoesthesia. In conclusion, CCH imparts a significant benefit on a couple's sexual health. Partner satisfaction with treatment is correlated with improved ability to have sexual intercourse and absence of patient glans hypoesthesia.
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Anaissie
authors.affiliation: Department of Urology, University of California at Irvine, Orange, CA, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Yafi
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Traore
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Sikka
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: W J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000627:therapeutic use*; D017060:Patient Satisfaction; D010411:Penile Induration / Q000188:drug therapy*; D010413:Penis / Q000187:drug effects; D010549:Personal Satisfaction; D012189:Retrospective Studies; D012747:Sexual Partners / Q000523:psychology*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D003012:Microbial Collagenase
keywords: Peyronie's disease; collagenase Clostridium histolyticum; partner satisfaction; patient satisfaction