title: A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania.
abstract: This work was aimed at correlating the chemotype of threeMenthaspecies cultivated in Romania with an in vivo study of the anti-inflammatory and antinociceptive effects of essential oils. The selected species wereMentha piperitaL. var.pallescens(white peppermint),Mentha spicataL. subsp.crispata(spearmint), andMentha suaveolensEhrh. (pineapple mint). Qualitative and quantitative analysis of the essential oils isolated from the selectedMenthaspecies was performed by gas chromatography coupled with mass spectrometry (GC-MS). The anti-inflammatory activity of the essential oils was determined by the rat paw edema test induced by λ-carrageenan. The antinociceptive effect of the essential oils was evaluated by the writhing test in mice, using 1% (v/v) acetic acid solution administered intraperitonealy and by the hot plate test in mice. The results showed a menthol chemotype forM. piperita pallescens, a carvone chemotype forM. spicata,and a piperitenone oxide chemotype forM. suaveolens. The essential oil fromM. spicataL. (EOMSP) produced statistically significant and dose-dependent anti-inflammatory and antinociceptive effects.
authors.affiliation: Department of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. cmogosan@umfcluj.ro.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mogosan
authors.affiliation: Department of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. oliviu_vostinaru@yahoo.com.
authors.forename: Oliviu
authors.initials: O
authors.lastname: Vostinaru
authors.affiliation: Department of Analytical Chemistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. roprean@umfcluj.ro.
authors.forename: Radu
authors.initials: R
authors.lastname: Oprean
authors.affiliation: Department of Drug Analysis, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. cmaier@umfcluj.ro.
authors.forename: Codruta
authors.initials: C
authors.lastname: Heghes
authors.affiliation: Department of Bromatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. lorenafilip@yahoo.com.
authors.forename: Lorena
authors.initials: L
authors.lastname: Filip
authors.affiliation: Department of Pharmaceutical Botany, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400337, Romania. bgeorgeta@umfcluj.ro.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Balica
authors.affiliation: SC Fares Biovital Laboratories SRL, Orastie 335700, Romania. cercetare@fares.ro.
authors.forename: Radu Ioan
authors.initials: RI
authors.lastname: Moldovan
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008297:Male; D027541:Mentha / Q000737:chemistry*; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D017208:Rats, Wistar; D012383:Romania
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009822:Oils, Volatile; D010936:Plant Extracts
keywords: Mentha spp.; anti-inflammatory; antinociceptive; carvone; menthol; piperitenone oxide