title: Seaweed Polysaccharides - New Therapeutic Insights Against the Inflammatory Response in Diabetic Nephropathy.
abstract: BACKGROUND
  The higher risk of diabetic nephropathy (DN) leads to end stage renal diseases worldwide, which is associated with chronic inflammation. Currently, the available treatments are limited, lack of efficacy and safety. Therefore, we are in need of novel targets and advanced treatments to reduce the necessity for the renal replacement therapy and burden of this disease management. Object/Methods: In this review, we performed through an inflammatory mechanism that contribute to DN, will provide a key point to the finding off novel therapeutic agents. In addition, we discuss the current anti-inflammatory drugs, an alternative approach of seaweed polysaccharides and also exploring the future perspective of anti-inflammatory natural seaweed compounds. Currently, seaweeds are taking majority of attention from scientists for targeting the various diseases. This will become a more significant part of the pipeline and alternate medicines for anti-inflammatory and chronic diseases.
  
  
  CONCLUSIONS
  The potential benefits of natural seaweed novel compounds in inhibiting inflammatory pathways would be useful for the prevention of diabetic nephropathy. Thus, this therapy manifests the clinical benefits of these compounds in the near future.
authors.affiliation: Renal Research Lab, Centre for Biomedical Research, School of Biosciences and Technology, VIT University, Vellore. India.
authors.forename: Durairaj
authors.initials: D
authors.lastname: Vaishnudevi
authors.affiliation: Department of Biosciences, School of Bio Sciences and Technology, VIT University, Vellore - 632014, Tamil Nadu. India.
authors.forename: Pragasam
authors.initials: P
authors.lastname: Viswanathan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D012624:Seaweed
chemical_list: D000893:Anti-Inflammatory Agents; D011134:Polysaccharides
keywords: Anti-inflammatory; chemokines; cytokines; diabetic nephropathy; hyperglycemia; inflammation; seaweed polysaccharides