title: Metal-mediated DNA assembly with ligand-based nucleosides.
abstract: Nucleic acids such as DNA are increasingly being applied in nanotechnology, as a result of their capability to self-assemble reversibly. The formal replacement of canonical base pairs by metal-mediated ones enables a site-specific introduction of metal-based functionality into these biomolecules, leading to the formation of predesigned metal arrays. This article offers an overview of structural aspects of metal-mediated base pairs, reviews recent advances in the field of metal-mediated base pairing and presents potential applications of the resulting metal-modified nucleic acids. It particularly focuses on recently developed metal-mediated base pairs with purine-derived nucleosides, gives an overview of metal-responsive systems relying on metal-mediated base pairs and summarizes various applications beyond metal-ion sensors.
authors.affiliation: Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 30, 48149 Münster, Germany(*).
authors.forename: Soham
authors.initials: S
authors.lastname: Mandal
authors.affiliation: Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 30, 48149 Münster, Germany(*). Electronic address: mueller.j@uni-muenster.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Müller
mesh_terms: D020029:Base Pairing; D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*
chemical_list: D008024:Ligands; D008670:Metals; D009705:Nucleosides; D004247:DNA