title: Neprilysin Inhibitors in Cardiovascular Disease.
abstract: Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blockers, and aldosterone antagonists. Recent trial data have shown a significant mortality benefit from ARNIs, which, as of May 2016, have now received a class I recommendation for use in patients with heart failure and reduced ejection fraction from the major American and European cardiology societies.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Falk Cardiovascular Research Center, 870 Quarry Road, Palo Alto, CA, 94304, USA. guson@stanford.edu.
authors.forename: Guson
authors.initials: G
authors.lastname: Kang
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Falk Cardiovascular Research Center, 870 Quarry Road, Palo Alto, CA, 94304, USA.
authors.forename: Dipanjan
authors.initials: D
authors.lastname: Banerjee
mesh_terms: D000613:Aminobutyrates / Q000627:therapeutic use*; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001713:Biphenyl Compounds; D004338:Drug Combinations; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D015260:Neprilysin / Q000037:antagonists & inhibitors*; D016032:Randomized Controlled Trials as Topic; D013777:Tetrazoles / Q000627:therapeutic use*; D000068756:Valsartan
chemical_list: D000613:Aminobutyrates; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001713:Biphenyl Compounds; D004338:Drug Combinations; D000451:Mineralocorticoid Receptor Antagonists; D013777:Tetrazoles; D000068756:Valsartan; D015260:Neprilysin; C549068:sacubitril and valsartan sodium hydrate drug combination
keywords: Heart failure; LCZ696; Neprilysin inhibitor; Sacubitril