title: [Alzheimer's disease and epilepsy].
abstract: Data regarding the incidence and prevalence of epileptic seizures in Alzheimer's disease show great variability and are clinically underestimated due to their atypical symptomatology. Considering their considerable negative effects on cognition and activities of daily living, epileptic seizures need to be correctly treated. Hypotheses with respect to the pathogenetic mechanisms and associations between Alzheimer's disease and epilepsy are mostly derived from animal experiments. The causal connections are so far insufficiently understood. Data on risk factors are inconsistent due to methodological limitations in studies. Clinical data for these indications show good response to therapy with anticonvulsants and good tolerability in the case of new active substances. When treating epileptic seizures in this patient collective using anticonvulsants, potential adverse effects and possible drug interactions need to be closely monitored.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland. robert.haussmann@uniklinikum-dresden.de.
authors.forename: R
authors.initials: R
authors.lastname: Haussmann
authors.affiliation: Sächsisches Epilepsiezentrum Radeberg, Wachauer Str. 30, 01454, Radeberg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Mayer
authors.affiliation: Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Schrempf
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Donix
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004347:Drug Interactions; D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000927:Anticonvulsants
keywords: Anticonvulsants; Electroencephalography; Epileptic seizures; Risk factors; Symptoms