title: Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder.
abstract: This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2-11 (n = 4749) and those 12-17 (n = 401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use. Among older children, only older age was associated with antipsychotic use. In at least one age group, antipsychotic medication use was also related to behaviour, family and occupational therapy, public insurance, site region, externalizing problems, body mass index, and sleep and gastrointestinal problems.
authors.affiliation: Underserved Populations Program Centre for Addiction and Mental Health, 1001 Queen St. W., Toronto, ON, M6J 1H4, Canada. johanna.lake@camh.ca.|Department of Psychiatry, University of Toronto, Toronto, Canada. johanna.lake@camh.ca.
authors.forename: Johanna K
authors.initials: JK
authors.lastname: Lake
authors.affiliation: Department of Psychiatry, Phoenix Children's Hospital, Phoenix, AZ, USA.
authors.forename: Danica
authors.initials: D
authors.lastname: Denton
authors.affiliation: Underserved Populations Program Centre for Addiction and Mental Health, 1001 Queen St. W., Toronto, ON, M6J 1H4, Canada.|Department of Psychiatry, University of Toronto, Toronto, Canada.
authors.forename: Yona
authors.initials: Y
authors.lastname: Lunsky
authors.affiliation: Massachusetts General Hospital, Biostatistics Center, Harvard Medical School, Boston, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Shui
authors.affiliation: Department of Psychiatry, Columbia University, New York, USA.|New York State Psychiatric Institute, New York, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Veenstra-VanderWeele
authors.affiliation: Holland Bloorview Research Institute, Toronto, Canada.|Department of Paediatrics, University of Toronto, Toronto, Canada.
authors.forename: Evdokia
authors.initials: E
authors.lastname: Anagnostou
mesh_terms: D000293:Adolescent; D000367:Age Factors; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000523:psychology / Q000628:therapy; D000067877:Autism Spectrum Disorder / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D011613:Psychotherapy / Q000379:methods / Q000706:statistics & numerical data*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D044469:Racial Groups / Q000706:statistics & numerical data
chemical_list: D014150:Antipsychotic Agents; D011619:Psychotropic Drugs
keywords: Atypical antipsychotic medication; Autism spectrum disorder; Children