title: Comparative efficacy of oral meloxicam and phenylbutazone in 2 experimental pain models in the horse.
abstract: The efficacy of oral phenylbutazone [PBZ; 4.4 mg/kg body weight (BW), q12h], a non-selective non-steroidal anti-inflammatory drug (NSAID), and oral meloxicam (MXM; 0.6 mg/kg BW, q24h), a COX-2 selective NSAID, were evaluated in 2 experimental pain models in horses: the adjustable heart bar shoe (HBS) model, primarily representative of mechanical pain, and the lipopolysaccharide-induced synovitis (SYN) model, primarily representative of inflammatory pain. In the HBS model, PBZ reduced multiple indicators of pain compared with the placebo and MXM. Meloxicam did not reduce indicators of pain relative to the placebo. In the SYN model, MXM and PBZ reduced increases in carpal skin temperature compared to the placebo. Meloxicam reduced lameness scores and lameness-induced changes in head movement compared to the placebo and PBZ. Phenylbutazone reduced lameness-induced change in head movement compared to the placebo. Overall, PBZ was more effective than MXM at reducing pain in the HBS model, while MXM was more effective at reducing pain in the SYN model at the oral doses used.
authors.affiliation: Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive, Calgary, Alberta T2N 4Z6.
authors.forename: Heidi
authors.initials: H
authors.lastname: Banse
authors.affiliation: Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive, Calgary, Alberta T2N 4Z6.
authors.forename: Alastair E
authors.initials: AE
authors.lastname: Cribb
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D005260:Female; D006736:Horses; D007794:Lameness, Animal / Q000188:drug therapy*; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D000077239:Meloxicam; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D010653:Phenylbutazone / Q000008:administration & dosage*; D012881:Skin Temperature / Q000187:drug effects; D013585:Synovitis / Q000188:drug therapy* / Q000662:veterinary; D013843:Thiazines / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D013843:Thiazines; D013844:Thiazoles; D010653:Phenylbutazone; D000077239:Meloxicam