title: Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study.
abstract: We analyzed changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during tenofovir-containing antiretroviral therapy among patients with a replicating HDV infection in the Swiss HIV Cohort Study. Only 28.6% experienced a ≥2.0 log reduction in HDV RNA, and 14.3% had undetectable HDV VL within 5 years.
authors.affiliation: Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Charles
authors.initials: C
authors.lastname: Béguelin
authors.affiliation: Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Nicole
authors.initials: N
authors.lastname: Friolet
authors.affiliation: Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
authors.forename: Darius
authors.initials: D
authors.lastname: Moradpour
authors.affiliation: Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
authors.forename: Roland
authors.initials: R
authors.lastname: Sahli
authors.affiliation: Institute for Infectious Diseases, Faculty of Medicine, University of Bern, Switzerland.
authors.forename: Franziska
authors.initials: F
authors.lastname: Suter-Riniker
authors.affiliation: Institute for Infectious Diseases, Faculty of Medicine, University of Bern, Switzerland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Lüthi
authors.affiliation: Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Switzerland
authors.forename: Matthias
authors.initials: M
authors.lastname: Cavassini
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.|Institute of Medical Virology, University of Zurich, Switzerland
authors.forename: Huldrych F
authors.initials: HF
authors.lastname: Günthard
authors.affiliation: Department of Infectious Diseases & Hospital Hygiene, University Hospital Basel, Switzerland
authors.forename: Manuel
authors.initials: M
authors.lastname: Battegay
authors.affiliation: Division of Infectious Diseases, Regional Hospital Lugano, Switzerland
authors.forename: Enos
authors.initials: E
authors.lastname: Bernasconi
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, Switzerland
authors.forename: Patrick
authors.initials: P
authors.lastname: Schmid
authors.affiliation: Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Switzerland.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Calmy
authors.affiliation: Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Andrew
authors.initials: A
authors.lastname: Atkinson
authors.affiliation: Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Andri
authors.initials: A
authors.lastname: Rauch
authors.affiliation: Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland.|Institute of Social and Preventive Medicine, University of Bern, Switzerland.
authors.forename: Gilles
authors.initials: G
authors.lastname: Wandeler
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000150:complications / Q000821:virology; D003699:Hepatitis D / Q000821:virology*; D003698:Hepatitis Delta Virus / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013557:Switzerland; D000068698:Tenofovir / Q000627:therapeutic use*; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir
keywords: coinfection; hepatitis delta virus; human immunodeficiency virus; replication; tenofovir