title: Repair of Oxidative DNA Damage in Saccharomyces cerevisiae.
abstract: Malfunction of enzymes that detoxify reactive oxygen species leads to oxidative attack on biomolecules including DNA and consequently activates various DNA repair pathways. The nature of DNA damage and the cell cycle stage at which DNA damage occurs determine the appropriate repair pathway to rectify the damage. Oxidized DNA bases are primarily repaired by base excision repair and nucleotide incision repair. Nucleotide excision repair acts on lesions that distort DNA helix, mismatch repair on mispaired bases, and homologous recombination and non-homologous end joining on double stranded breaks. Post-replication repair that overcomes replication blocks caused by DNA damage also plays a crucial role in protecting the cell from the deleterious effects of oxidative DNA damage. Mitochondrial DNA is also prone to oxidative damage and is efficiently repaired by the cellular DNA repair machinery. In this review, we discuss the DNA repair pathways in relation to the nature of oxidative DNA damage in Saccharomyces cerevisiae.
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, P. O. Box 17666, Al Ain, United Arab Emirates.
authors.forename: Jisha
authors.initials: J
authors.lastname: Chalissery
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, P. O. Box 17666, Al Ain, United Arab Emirates.
authors.forename: Deena
authors.initials: D
authors.lastname: Jalal
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, P. O. Box 17666, Al Ain, United Arab Emirates.
authors.forename: Zeina
authors.initials: Z
authors.lastname: Al-Natour
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, P. O. Box 17666, Al Ain, United Arab Emirates. Electronic address: ahmedh@uaeu.ac.ae.
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Hassan
mesh_terms: D002467:Cell Nucleus / Q000235:genetics; D004249:DNA Damage; D004260:DNA Repair; D004271:DNA, Fungal / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics; D018384:Oxidative Stress; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D004271:DNA, Fungal
keywords: Base excision repair; Mitochondrial DNA; Oxidative DNA damage; Reactive oxygen species