title: Two new cytotoxic glycosides isolated from the green walnut husks of Juglans mandshurica Maxim.
abstract: Two new glycosides including an alcohol glycoside and a phenolic glycoside: hexyl-1-O-α-d-arabinofuranosyl-(1 → 6)-β-d-glucopyranoside (1), 4-hydroxypropiophenone-4-O-β-d-glucopyranosyl(1 → 6)-β-d-glucopyranoside(2), along with six known naphthalenyl glucosides (3-8) were isolated from green walnut husks of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. All compounds were evaluated for their inhibitory effects on tumour cells (BGC-823, HepG-2, MCF-7). The results showed that new compounds 1 and 2 had superior inhibitory activity in comparison with other naphthalenyl glucosides.
authors.affiliation: a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhou
authors.affiliation: b Quality Testing Branch , Veterinary Drug and Feed Supervision Institute of Heilongjiang Province , Harbin , P.R. China.
authors.forename: Quan-Yu
authors.initials: QY
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Bing-You
authors.initials: BY
authors.lastname: Yang
authors.affiliation: a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Jiang
authors.affiliation: a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Guo
authors.affiliation: a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Haixue
authors.initials: H
authors.lastname: Kuang
mesh_terms: D000438:Alcohols / Q000032:analysis; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000032:analysis / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D006910:Hydroxypropiophenone; D031324:Juglans / Q000737:chemistry*; D015394:Molecular Structure; D009754:Nuts / Q000737:chemistry*; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000438:Alcohols; D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D006910:Hydroxypropiophenone; C069170:4-hydroxypropiophenone
keywords: Juglans mandshurica; alcohol glycoside; cytotoxic activity; phenolic glycoside