title: Combinatorial Mixtures of Multiparameter Distributions: An Application to Bivariate Data.
abstract: We introduce combinatorial mixtures - a flexible class of models for inference on mixture distributions whose components have multidimensional parameters. The key idea is to allow each element of the component-specific parameter vectors to be shared by a subset of other components. This approach allows for mixtures that range from very flexible to very parsimonious and unifies inference on component-specific parameters with inference on the number of components. We develop Bayesian inference and computational approaches for this class of distributions, and illustrate them in an application. This work was originally motivated by the analysis of cancer subtypes: in terms of biological measures of interest, subtypes may be characterized by differences in location, scale, correlations or any of the combinations. We illustrate our approach using publicly available data on molecular subtypes of lung and prostate cancers.
authors.affiliation: .
authors.forename: Valeria
authors.initials: V
authors.lastname: Edefonti
authors.affiliation: .
authors.forename: Giovanni
authors.initials: G
authors.lastname: Parmigiani
mesh_terms: D001499:Bayes Theorem; D006801:Humans; D008390:Markov Chains; D009010:Monte Carlo Method; D009369:Neoplasms / Q000175:diagnosis*
keywords: Bayesian inference; Markov chain Monte Carlo; clustering; mixture models with unknown number of components