title: A case report of rare palmoplantar keratosis and nail dystrophy with imatinib.
abstract: A 48-year-old woman developed palmoplantar hyperkeratosis during treatment with imatinib (400mg/day) for treatment of chronic myeloid leukemia. After 5months of treatment, she developed plantar lesions with yellow-brownish plaques and palmar desquamations. The skin biopsy has eliminated psoriasis. Imatinib was discontinued, and treatment with an emollient balm and a soothing repair cream with an improvement of symptoms. A French imputability assessment score of I3 was obtained, indicating a probable relationship between the side effect and imatinib. In our case, the skin adverse events require definitive drug discontinuation and change of treatment.
authors.affiliation: Faculty of medicine and pharmacy, university of Mohamed V Rabat, 10170 Rabat, Morocco. Electronic address: benabbesmajda@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Benabbes
authors.affiliation: Service of internal medicine, university hospital center Ibn Sina, 10170 Rabat, Morocco.
authors.forename: Z
authors.initials: Z
authors.lastname: Tazi Mezalek
authors.affiliation: Service of pharmacy, National institute of oncology, 10170 Rabat, Morocco.
authors.forename: B
authors.initials: B
authors.lastname: Meddah
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D005528:Foot / Q000473:pathology; D006225:Hand / Q000473:pathology; D006801:Humans; D000068877:Imatinib Mesylate / Q000009:adverse effects*; D007645:Keratoderma, Palmoplantar / Q000139:chemically induced* / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D009260:Nail Diseases / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate
keywords: Dystrophie des ongles; Hyperkératose palmoplantaire; Imatinib; Nail dystrophy; Palmoplantar hyperkeratosis