title: The third-time chronic myeloid leukemia in lymphoblastic crisis with ABL1 kinase mutation induced by decitabine, dexamethason combined with nilotinib and dasatinib.
abstract: Blast crisis (BC) is the major remaining challenge in the management of chronic myeloid leukemia (CML). The prognosis of the BC patient who carries ABL kinase mutation is very poor. One patient, with lymphoid CML-BC third time, was detected withT315A/F359I/M244Vcompound mutation by direct sequencing after treatment with tyrosine kinase inhibitions three years. The patient was treated with decitabine, dexamethasone, in combination with nilotinib and dasatinib. Then this patient received a complete hematologic response and cytogenetic response after two cycles of treatment.
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Suli
authors.initials: S
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Qiao
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Shen
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Guangsheng
authors.initials: G
authors.lastname: He
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Li
keywords: F359I; M244VA; T315A; chronic myeloid leukemia; decitabine; lymphoid blast crisis