title: Environmental epigenomics: Current approaches to assess epigenetic effects of endocrine disrupting compounds (EDC's) on human health.
abstract: Environmental Epigenomics is a developing field to study the epigenetic effect on human health from exposure to environmental factors. Endocrine disrupting chemicals have been detected primarily in pharmaceutical drugs, personal care products, food additives, and food containers. Exposure to endocrine-disrupting chemicals (EDCs) has been associated with a high incidence and prevalence of many endocrine-related disorders in humans. Nevertheless, further evidence is needed to establish a correlation between exposure to EDC and human disorders. Conventional detection of EDCs is based on chemical structure and concentration sample analysis. However, substantial evidence has emerged, suggesting that cell exposure to EDCs leads to epigenetic changes, independently of its chemical structure with non-monotonic low-dose responses. Consequently, a paradigm shift in toxicology assessment of EDCs is proposed based on a comprehensive review of analytical techniques used to evaluate the epigenetic effects. Fundamental insights reported elsewhere are compared in order to establish DNA methylation analysis as a viable method for assessing endocrine disruptors beyond the conventional study approach of chemical structure and concentration analysis.
authors.affiliation: Departamento de Alimentos y Biotecnología, Facultad de Química, Universidad Nacional Autónoma de México, Circuito Escolar s/n Ciudad Universitaria, Distrito Federal, Mexico. Electronic address: nattapia@gmail.com.
authors.forename: Natalia
authors.initials: N
authors.lastname: Tapia-Orozco
authors.affiliation: Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK; Abraxas Biolabs SAPI de CV, Donato Guerra 9, Álvaro Obregón, Distrito Federal, Mexico. Electronic address: gerardo.santiago.14@ucl.ac.uk.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Santiago-Toledo
authors.affiliation: Unidad de Medicina Genómica, Hospital General de México, Dr Balmis 148, Distrito Federal, Mexico. Electronic address: valeirabarron@gmail.com.
authors.forename: Valeria
authors.initials: V
authors.lastname: Barrón
authors.affiliation: Unidad de Medicina Genómica, Hospital General de México, Dr Balmis 148, Distrito Federal, Mexico. Electronic address: anaesga@hotmail.com.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Espinosa-García
authors.affiliation: Unidad de Medicina Genómica, Hospital General de México, Dr Balmis 148, Distrito Federal, Mexico. Electronic address: drjagarcia2@prodigy.net.mx.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: García-García
authors.affiliation: Departamento de Alimentos y Biotecnología, Facultad de Química, Universidad Nacional Autónoma de México, Circuito Escolar s/n Ciudad Universitaria, Distrito Federal, Mexico. Electronic address: roeb@unam.mx.
authors.forename: Roeb
authors.initials: R
authors.lastname: García-Arrazola
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000187:drug effects*; D052244:Endocrine Disruptors / Q000032:analysis / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D044127:Epigenesis, Genetic / Q000187:drug effects* / Q000235:genetics; D057890:Epigenomics; D005260:Female; D006801:Humans; D008297:Male; D012098:Reproduction / Q000187:drug effects / Q000235:genetics
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants
keywords: Endocrine-disrupting chemicals; Epigenetic analysis; Monitoring