title: Outcome of solid-state 532 nm green laser in high-risk retinopathy of prematurity at a tertiary care centre in India.
abstract: OBJECTIVE
  The purpose of this study was to analyse the outcome of solid-state green laser in high-risk retinopathy of prematurity (ROP) at a tertiary centre in India.
  
  
  METHODS
  Fifty-nine eyes of 30 infants with high-risk ROP were recruited in this prospective, interventional study. High-risk ROP included prethreshold type 1 ROP and APROP. Laser photocoagulation was performed with 532 nm solid-state green laser (Novus Spectra, Lumenis, GmbH, Germany).
  
  
  RESULTS
  Of the 30 infants, 18 were males (60%) and 12 were females (40%). The mean birth weight was 1102.83 ± 196.27 g. The mean gestational age was 29.5 ± 1.47 weeks. Zone 1 disease was present in 10 eyes (16.95%) and zone 2 disease in 49 (83.05%) eyes. Out of 57 eyes with prethreshold type 1 ROP, 39 eyes (68.42%) had stage 2 and 18 eyes (31.58%) had stage 3. The postconceptional age at the time of treatment was 36.03 ± 2.32 weeks. The infants received mean 2710.24 ± 747.97 laser spots. Fifty (84.8%) eyes underwent laser in a single sitting and 9 eyes (15.2%) required 2 laser sittings. Mean time for regression of ROP was 5.8 ± 3.8 weeks (range 3-11 weeks). Total ROP regression was seen in 55 eyes (93.22%). Despite laser treatment, 4 (6.78%) eyes of three infants had unfavourable outcome. One infant developed intra-procedural bradycardia. Vitreous haemorrhage was seen in five eyes (8.4%).
  
  
  CONCLUSIONS
  Solid-state 532 nm green laser is a safe and effective treatment for high-risk retinopathy of prematurity.
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Government Medical College, Amritsar, Punjab, 143001, India.
authors.forename: Kanika
authors.initials: K
authors.lastname: Chhabra
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Government Medical College, Amritsar, Punjab, 143001, India.
authors.forename: Prempal
authors.initials: P
authors.lastname: Kaur
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Government Medical College, Amritsar, Punjab, 143001, India.
authors.forename: Karamjit
authors.initials: K
authors.lastname: Singh
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Government Medical College, Amritsar, Punjab, 143001, India. dr.anandaggarwal@gmail.com.
authors.forename: Anand
authors.identifier: http://orcid.org/0000-0002-0445-4224
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Government Medical College, Amritsar, Punjab, 143001, India.
authors.forename: Dharamvir
authors.initials: D
authors.lastname: Chalia
mesh_terms: D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D017075:Laser Coagulation / Q000379:methods*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D012307:Risk Factors; D062606:Tertiary Care Centers; D016896:Treatment Outcome; D014792:Visual Acuity
keywords: Aggressive Posterior Retinopathy of Prematurity; Prethreshold type 1 ROP; Retinopathy of prematurity; Solid-state green laser