title: Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease.
abstract: There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 mL/kg saline. Behavioral test (the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease.
authors.affiliation: Department of Biology, Faculty of Science, Arak University, Arak, Iran; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Matin
authors.identifier: 0000-0003-0218-968X
authors.initials: M
authors.lastname: Ramezani
authors.affiliation: Department of Biology, Faculty of Science, Arak University, Arak, Iran.
authors.forename: Niloufar
authors.initials: N
authors.lastname: Darbandi
authors.affiliation: Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Khodagholi
authors.affiliation: Department of Biology, Faculty of Science, Arak University, Arak, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Hashemi
keywords: Alzheimer's disease; CA3 region; behavioral test; hippocampus; myricetin; nerve regeneration; neural regeneration; pyramidal neurons; streptozotocin