title: Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.
abstract: Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.
authors.affiliation: Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain. fedra.luciano@gmail.com.
authors.forename: Fedra
authors.initials: F
authors.lastname: Luciano-Mateo
authors.affiliation: Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain. anna.hernandeza@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Hernández-Aguilera
authors.affiliation: Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain. noemi.cabre@gmail.com.
authors.forename: Noemi
authors.initials: N
authors.lastname: Cabre
authors.affiliation: Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain. jcamps@grupsagessa.com.
authors.forename: Jordi
authors.initials: J
authors.lastname: Camps
authors.affiliation: Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain. salvador.fernandez@iispv.cat.|Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain. salvador.fernandez@iispv.cat.
authors.forename: Salvador
authors.initials: S
authors.lastname: Fernández-Arroyo
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. jlopezmir@uco.es.
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
authors.affiliation: Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain. jmenendez@idibgi.org.|ProCURE (Program against Cancer Therapeutic Resistance), Metabolism and Cancer Group, Catalan Institute of Oncology, 17190 Girona, Spain. jmenendez@idibgi.org.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Menendez
authors.affiliation: Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain. jorge.joven@urv.cat.|The Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain. jorge.joven@urv.cat.
authors.forename: Jorge
authors.initials: J
authors.lastname: Joven
mesh_terms: D002244:Carbon / Q000378:metabolism*; D004032:Diet; D004734:Energy Metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008687:Metformin / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism
chemical_list: D007004:Hypoglycemic Agents; D002244:Carbon; D008687:Metformin
keywords: diabetes mellitus; energy intake; epigenetics; folic acid; food source; food-drug interactions; obesity; vitamins B