title: Differences in the Clinical Characteristics of Early- and Late-Onset Necrotizing Enterocolitis in Full-Term Infants: A Retrospective Case-Control Study.
abstract: Information regarding the influence of age at onset on prognosis in full-term infants with necrotizing enterocolitis (NEC) is limited, and identifying differences between the clinical characteristics of early-onset NEC (EO-NEC) and late-onset NEC (LO-NEC) may be helpful in the determination of effective management strategies. In the present study, the medical records of 253 full-term infants with NEC were reviewed, and the clinical characteristics of the EO-NEC group (n = 150) and the LO-NEC group (n = 103) were compared. Infants in the EO-NEC group were characterized by increased gestational age and higher rates of stage III NEC and peritonitis when compared with LO-NEC infants (P  < 0.05). Mortality was significantly associated with stage III NEC, peritonitis, sepsis, respiratory failure and shock in univariate analysis (P < 0.05). In logistic regression analysis, peritonitis and renal failure were identified as independent risk factors for mortality in infants with EO-NEC, and peritonitis and respiratory failure were significant predictors of mortality in neonates with LO-NEC. Our finding indicated that the characteristics of the severe medical conditions identified in infants with EO-NEC were distinct from those observed in infants with LO-NEC. Peritonitis and kidney failure and peritonitis and respiratory failure were identified as risk factors for mortality in EO-NEC and LO-NEC infants, respectively.
authors.affiliation: Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Key Laboratory of Pediatrics in Chongqing. Chongqing, 400014, P.R. China.
authors.forename: Qiu-Yu
authors.initials: QY
authors.lastname: Li
authors.affiliation: Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Key Laboratory of Pediatrics in Chongqing. Chongqing, 400014, P.R. China.
authors.forename: Yao
authors.initials: Y
authors.lastname: An
authors.affiliation: Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Key Laboratory of Pediatrics in Chongqing. Chongqing, 400014, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Key Laboratory of Pediatrics in Chongqing. Chongqing, 400014, P.R. China.
authors.forename: Xue-Qiu
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Key Laboratory of Pediatrics in Chongqing. Chongqing, 400014, P.R. China.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Key Laboratory of Pediatrics in Chongqing. Chongqing, 400014, P.R. China.
authors.forename: Zheng-Li
authors.initials: ZL
authors.lastname: Wang
authors.affiliation: Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders; Key Laboratory of Pediatrics in Chongqing. Chongqing, 400014, P.R. China.
authors.forename: Lu-Quan
authors.initials: LQ
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D002423:Cause of Death; D020345:Enterocolitis, Necrotizing / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D008297:Male; D010538:Peritonitis / Q000401:mortality; D011379:Prognosis; D051437:Renal Insufficiency / Q000401:mortality; D012131:Respiratory Insufficiency / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000401:mortality