title: Image-based modelling of skeletal muscle oxygenation.
abstract: The supply of oxygen in sufficient quantity is vital for the correct functioning of all organs in the human body, in particular for skeletal muscle during exercise. Disease is often associated with both an inhibition of the microvascular supply capability and is thought to relate to changes in the structure of blood vessel networks. Different methods exist to investigate the influence of the microvascular structure on tissue oxygenation, varying over a range of application areas, i.e. biologicalin vivoandin vitroexperiments, imaging and mathematical modelling. Ideally, all of these methods should be combined within the same framework in order to fully understand the processes involved. This review discusses the mathematical models of skeletal muscle oxygenation currently available that are based upon images taken of the muscle microvasculaturein vivoandex vivoImaging systems suitable for capturing the blood vessel networks are discussed and respective contrasting methods presented. The review further informs the association between anatomical characteristics in health and disease. With this review we give the reader a tool to understand and establish the workflow of developing an image-based model of skeletal muscle oxygenation. Finally, we give an outlook for improvements needed for measurements and imaging techniques to adequately investigate the microvascular capability for oxygen exchange.
authors.affiliation: Helmholtz-Zentrum für Material- und Küstenforschung, Geesthacht, Germany berit.zeller-plumhoff@hzg.de.|Bioengineering Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
authors.forename: B
authors.identifier: 0000-0002-7562-9423
authors.initials: B
authors.lastname: Zeller-Plumhoff
authors.affiliation: Bioengineering Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
authors.forename: T
authors.identifier: 0000-0001-8710-1063
authors.initials: T
authors.lastname: Roose
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: G F
authors.initials: GF
authors.lastname: Clough
authors.affiliation: Bioengineering Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
authors.forename: P
authors.identifier: 0000-0001-7499-3576
authors.initials: P
authors.lastname: Schneider
mesh_terms: D000818:Animals; D006801:Humans; D018613:Microscopy, Confocal; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000166:cytology / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*
keywords: computational modelling; image-based modelling; imaging; oxygenation; skeletal muscle; vasculature