title: Evaluation of BAALC gene expression in normal cytogenetic acute myeloid leukemia patients in north-east of Iran.
abstract: Background:Acute myeloid leukemia (AML) is known as one of the most common leukemia among adults. Environmental and different genetic factors affect disease process, prognosis and treatment. Among different genetic factors NPM1, FLT3, MLL and BAALC genes are the most effective on patient's survival rate. The aim of this study was to assess amount of BAALC gene expression in AML patients, and its relation to survival rate.Methods:In this case-control study, from all 94 individuals referred to Ghaem Medical Center during 2012-2015, 47 cases were normal cytogenetic AML and others were healthy individuals that were studied as control group. Real-time PCR method was applied for gene expression evaluation. Other information of patients was extracted from medical documents. SPSS v.21 was used for data processing.Results:Mean age of studied cases was 31.50 years. The most of BAALC gene expression was seen in M1 and M2 subtypes, and the less was in M5. A significant relation was found between amount of gene expression and patient's survival rate.Conclusion:BAALC gene expression was increased significantly in AML cases. BAALC expression had reverse relation with patients' survival rate in North-East of Iran.
authors.affiliation: MSc student of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran. amirpourm1@mums.ac.ir.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Amirpour
authors.affiliation: MD, Associate Professor of Hematopathology, Cancer Molecular Pathology Research Center, Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ayatollahihossein@yahoo.com.
authors.forename: Hossein
authors.initials: H
authors.lastname: Ayatollahi
authors.affiliation: MSc, Cancer Molecular Pathology Research Center, Department of Hematology and Blood Bank, Mashhad University of Medical Sciences, Mashhad, Iran. Iran. msheikhi2@yahoo.com.
authors.forename: Maryam
authors.initials: M
authors.lastname: Sheikhi
authors.affiliation: MSc Student of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran. azarkerdars921@mums.ac.ir.
authors.forename: Somaye
authors.initials: S
authors.lastname: Azarkerdar
authors.affiliation: MSc, Cancer Molecular Pathology Research Center, Department of Hematology and Blood Bank, Mashhad University of Medical Sciences, Mashhad, Iran. shams8869@yahoo.com.
authors.forename: Seyyede Fatemeh
authors.initials: SF
authors.lastname: Shams
keywords: Acute myeloid leukemia; Prognosisampus; Survival rate