title: Adhesives based on butyl-cyanoacrylate for fixation of autologous bone graft: Pilot study in rabbits.
abstract: OBJECTIVE
  Injuries to bone during trauma may require bone grafts and/or fixation to ensure optimal healing. Autologous bone grafts are still very common, but little data exist regarding the most effective means of fixation of such grafts. The aim of this study was to compare the fixation of autologous bone grafts with titanium screws and adhesives based on n-butyl-cyanoacrylate.
  
  
  METHODS
  Twenty adult rabbits were used. In group I, the graft was fixed with titanium screws (in one side of the animal head), while in groups II and III (in other spots in the same animal head), the graft was fixed with adhesive Tissuacryl® and Histoacryl®, respectively. The animals were sacrificed on post-operative days 7, 15, 30, 60, and 120. Histological and histomorphometric analyses were performed.
  
  
  RESULTS
  Inflammatory reactions were observed in all groups at 7 days. At 15 days, group I showed no inflammatory reaction. There was new bone formation in group I at 30 days and at 60 days in groups II and III. After 120 days, the grafts were completely incorporated in group I and partially incorporated in groups II and III. Groups II and III presented less graft resorption at the final evaluation: 32.58 (±10.22) and 34.75 (±8.25), compared to 26.58 (±6.48) for group I (P=.001).
  
  
  CONCLUSIONS
  The adhesives were compatible when they were in contact with bone structures, and they were effective in fixing the grafts. Groups II and III had less graft resorption.
authors.affiliation: Department of Diagnosis and Oral and Maxillofacial Surgery, Dental School of Araraquara, UNESP, Araraquara, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hochuli-Vieira
authors.affiliation: Department of Diagnosis and Oral and Maxillofacial Surgery, Dental School of Araraquara, UNESP, Araraquara, Brazil.
authors.forename: Ana Carolina Basso
authors.initials: ACB
authors.lastname: Engler Pinto
authors.affiliation: Department of Diagnosis and Oral and Maxillofacial Surgery, Dental School of Araraquara, UNESP, Araraquara, Brazil.
authors.forename: Valfrido Antonio
authors.initials: VA
authors.lastname: Pereira-Filho
authors.affiliation: Department of General and Inorganic Chemistry, Institute of Chemistry at Araraquara, UNESP, Araraquara, Brazil.
authors.forename: Sybele
authors.initials: S
authors.lastname: Saska
authors.affiliation: Department of Diagnosis and Oral and Maxillofacial Surgery, Dental School of Araraquara, UNESP, Araraquara, Brazil.
authors.forename: Marcelo Silva
authors.identifier: http://orcid.org/0000-0001-6142-4630
authors.initials: MS
authors.lastname: Monnazzi
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000517:prevention & control; D001863:Bone Screws; D016025:Bone Transplantation; D004659:Enbucrilate / Q000494:pharmacology*; D008297:Male; D010012:Osteogenesis; D010865:Pilot Projects; D011817:Rabbits; D012886:Skull / Q000601:surgery*; D014025:Titanium; D014182:Transplantation, Autologous
chemical_list: D014025:Titanium; D004659:Enbucrilate
keywords: bone grafts; cyanoacrylate adhesives; sequelae reconstruction