title: Trimethoprim-sulfamethoxazole therapy for patients with carbapenemase-producing Klebsiella pneumoniae infections: retrospective single-center case series.
abstract: OBJECTIVE
  The objective of the study was to evaluate the efficacy and tolerability of trimethoprim-sulfamethoxazole (also known as co-trimoxazole, TMPS) to treat Klebsiella pneumoniae (Kp)-K. pneumoniae carbapenemase (KPC) infections.
  
  
  METHODS
  Clinical data of patients with a TMPS-susceptible Kp-KPC infection were collected as a case series.
  
  
  RESULTS
  We report clinical outcomes and tolerability for 14 patients infected by Kp-KPC strains susceptible to TMPS, including three bloodstream infections. In ten cases (71.4%), TMPS was administered as monotherapy. In all but one case, Kp-KPC infection was cured. In the remaining patient, therapy was discontinued because of an adverse event.
  
  
  CONCLUSIONS
  The use of TMPS to treat TMPS-susceptible Kp-KPC infections seems promising.
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy. ritamurri@rm.unicatt.it.
authors.forename: Rita
authors.initials: R
authors.lastname: Murri
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Fiori
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Spanu
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Mastrorosa
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giovannenze
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Taccari
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Palazzolo
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Scoppettuolo
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Ventura
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sanguinetti
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cauda
authors.affiliation: Department of Infectious Diseases, Department of Microbiology, Catholic University of Rome, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Fantoni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000378:metabolism*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects / Q000627:therapeutic use*; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Carbapenemase; Co-trimoxazole; KPC; Multidrug-resistant infections; Trimethoprim–sulfamethoxazole