title: A prospective comparison between auto-registration and manual registration of real-time ultrasound with MR images for percutaneous ablation or biopsy of hepatic lesions.
abstract: To compare the accuracy and required time for image fusion of real-time ultrasound (US) with pre-procedural magnetic resonance (MR) images between positioning auto-registration and manual registration for percutaneous radiofrequency ablation or biopsy of hepatic lesions.
  
  
  
  This prospective study was approved by the institutional review board, and all patients gave written informed consent. Twenty-two patients (male/female, n = 18/n = 4; age, 61.0 ± 7.7 years) who were referred for planning US to assess the feasibility of radiofrequency ablation (n = 21) or biopsy (n = 1) for focal hepatic lesions were included. One experienced radiologist performed the two types of image fusion methods in each patient. The performance of auto-registration and manual registration was evaluated. The accuracy of the two methods, based on measuring registration error, and the time required for image fusion for both methods were recorded using in-house software and respectively compared using the Wilcoxon signed rank test.
  
  
  
  Image fusion was successful in all patients. The registration error was not significantly different between the two methods (auto-registration: median, 3.75 mm; range, 1.0-15.8 mm vs. manual registration: median, 2.95 mm; range, 1.2-12.5 mm, p = 0.242). The time required for image fusion was significantly shorter with auto-registration than with manual registration (median, 28.5 s; range, 18-47 s, vs. median, 36.5 s; range, 14-105 s, p = 0.026).
  
  
  
  Positioning auto-registration showed promising results compared with manual registration, with similar accuracy and even shorter registration time.
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul, 06351, South Korea.
authors.forename: Dong Ik
authors.initials: DI
authors.lastname: Cha
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul, 06351, South Korea. leeminwoo0@gmail.com.
authors.forename: Min Woo
authors.initials: MW
authors.lastname: Lee
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul, 06351, South Korea.
authors.forename: Kyoung Doo
authors.initials: KD
authors.lastname: Song
authors.affiliation: Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea.
authors.forename: Young-Taek
authors.initials: YT
authors.lastname: Oh
authors.affiliation: Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea.
authors.forename: Ja-Yeon
authors.initials: JY
authors.lastname: Jeong
authors.affiliation: Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea.
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Chang
authors.affiliation: Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Ryu
authors.affiliation: Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea.
authors.forename: Kyong Joon
authors.initials: KJ
authors.lastname: Lee
authors.affiliation: Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea.
authors.forename: Jaeil
authors.initials: J
authors.lastname: Kim
authors.affiliation: Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea.
authors.forename: Won-Chul
authors.initials: WC
authors.lastname: Bang
authors.affiliation: Infrastructure Technology Lab, R&D Center, Samsung Medison, Seoul, South Korea.
authors.forename: Dong Kuk
authors.initials: DK
authors.lastname: Shin
authors.affiliation: Infrastructure Technology Lab, R&D Center, Samsung Medison, Seoul, South Korea.
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Choi
authors.affiliation: Infrastructure Technology Lab, R&D Center, Samsung Medison, Seoul, South Korea.
authors.forename: Dalkwon
authors.initials: D
authors.lastname: Koh
authors.affiliation: Infrastructure Technology Lab, R&D Center, Samsung Medison, Seoul, South Korea.
authors.forename: Bong Koo
authors.initials: BK
authors.lastname: Seo
authors.affiliation: Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, South Korea.
authors.forename: Kyunga
authors.initials: K
authors.lastname: Kim
mesh_terms: D001706:Biopsy / Q000379:methods*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*
keywords: Automatic registration; Biopsy; Fusion imaging; Liver; Radiofrequency ablation