title: Analysis of human serum metabolome for potential biomarkers identification of erosive oral lichen planus.
abstract: BACKGROUND
  Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment.
  
  
  METHODS
  Ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) combined with pattern recognition approaches were integrated to acquire differentially expressed metabolites for the pathways analysis and elucidate mechanisms of disease.
  
  
  RESULTS
  Totally, 10 modulated metabolites were characterized as the potential biomarkers of erosive OLP, whose dysregulations could affect multiple metabolic pathways and pathological processes in the disease.
  
  
  CONCLUSIONS
  These findings indicated that the analysis of human serum metabolome might be conducive to the achievement of the objectives of this study.
authors.affiliation: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors.forename: Xu-Yan
authors.initials: XY
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, Guiyang University of Chinese Medicine, Guiyang 550025, PR China. Electronic address: laurahoney@163.com.
authors.forename: Shuai-Nan
authors.initials: SN
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Guiyang University of Chinese Medicine, Guiyang 550025, PR China. Electronic address: xuzhaoli86@yeah.net.
authors.forename: Xu-Zhao
authors.initials: XZ
authors.lastname: Li
authors.affiliation: Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Stomatology, Harbin Medical University, Harbin 151000, PR China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Yin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000097:blood* / Q000378:metabolism*; D008297:Male; D055432:Metabolomics; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Erosive oral lichen planus; Metabolomics study; Potential biomarkers