title: Abnormal functional networks in resting-state of the sub-cortical chronic stroke patients with hemiplegia.
abstract: The aim of this study is to identify the properties of the motor network and the default-mode network (DMN) of the sub-cortical chronic stroke patients, and to study the relationship between the network connectivity and the neurological scales of the stroke patients. Twenty-eight chronic stroke patients (28-77days post-stroke) and twenty-eight healthy control subjects (HCs) were recruited. Independent component analysis (ICA) was performed to obtain the motor network and the DMN. Two sample t-tests was used to compare the differences of the motor network and the DMN between the patients and HCs. Additionally, correlations between the network connectivity and the behavioral scores of the stroke patients were studied. Compared with the HCs, the motor network connectivity of the stroke patients was significantly increased in the contralesional superior parietal lobule, but decreased in ipsilesional M1. The DMN connectivity of the stroke patients was significantly increased in the contralesional middle frontal gyrus, but decreased in bilateral precuneus, ipsilesional supramarginal and angular gyrus. Moreover, the motor network connectivity of the contralesional superior parietal lobule was positively correlated with the Fugl-Meyer assessment (FMA) score of the stroke patients. Our results showed abnormal motor network and DMN during the resting-state of the stroke patients, suggesting that resting-state network connectivity could serve as biomarkers for future stroke studies. Brain-behavior relationships could be taken into account while evaluating stroke patients.
authors.affiliation: Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Rehabilitation, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Rubing
authors.initials: R
authors.lastname: Yan
authors.affiliation: Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Jingna
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Linqiong
authors.initials: L
authors.lastname: Sang
authors.affiliation: Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Pengyue
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Rehabilitation, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: liuhongliangkf@163.com.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing, China. Electronic address: qiumingguo@yahoo.com.
authors.forename: Mingguo
authors.initials: M
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006429:Hemiplegia / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008564:Membrane Potentials / Q000502:physiology*; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D010296:Parietal Lobe / Q000503:physiopathology; D017397:Prefrontal Cortex; D020521:Stroke / Q000150:complications / Q000503:physiopathology*
keywords: DMN; FMA; ICA; Resting-state fMRI; Stroke; The motor network