title: Yin-ColdorYang-HeatSyndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept.
abstract: Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCMYin-cold (YC)orYang-heat (YH)syndrome types and theEGFRgene status, we prospectively studied 310 NSCLC patients. TCMYHorYCwas diagnosed by three TCM experts. TCM symptoms and signs were entered into a binary cluster analysis. The relationships between theEGFRgene status,YHorYCsyndrome types, and classification by cluster analysis were analyzed using the chi-square test and multivariate logistic regression. In the 299 patients who had theirEGFRgene tested, 45.24%YC(76/168) and 25.95%YH(34/131) patients hadEGFRmutations (p= 0.001). Among the 292 patients entered into the cluster analysis, 132 were classified into group A, with signs and symptoms similar toYC, whereas 160 group B patients were similar toYH. In the 281 patients withEGFRtested, 45.67% group A (58/127) and 28.57% group B patients (44/154) hadEGFRmutations (p= 0.003). TheEGFRstatus was independently correlated with TCM syndrome type and classification by cluster analysis on multivariate logistic regression. NSCLC patients withYCwere more likely to haveEGFRgene mutations.
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Yan-Juan
authors.identifier: 0000-0002-1956-7774
authors.initials: YJ
authors.lastname: Zhu
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Hai-Bo
authors.identifier: 0000-0001-8104-4280
authors.initials: HB
authors.lastname: Zhang
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Liu
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Fu-Li
authors.initials: FL
authors.lastname: Zhang
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Bai
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Qu
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Qu
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Chen
authors.affiliation: Oncology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Division of Speech & Hearing Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Luo
authors.affiliation: Department of Big Medical Data, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Ou