title: Immunohistochemical features of multifocal and multicentric lobular breast carcinoma.
abstract: OBJECTIVE
  Patient age, tumor size, axillary lymph node status, expression of estrogen, progesterone and HER2 receptors, as well as the histological grade, are widely accepted prognostic and predictive parameters in breast carcinoma. In invasive lobular carcinoma (ILC), the prognostic factors, such as nodal status and tumor size are believed to be the most valuable ones. The aim of this was set to determine the possible linkage between MFity/MCity of ILC and immunohistochemical predictive (ER, PR, HER2) and prognostic parameters (BRCA1, p53, E-cadherin, Ki-67).
  
  
  METHODS
  Out of 2486 cases diagnosed with BC from south-eastern Serbia, the presence ILC was noted in 334 cases. Immunohistochemical characterization of predictive and prognostic parameters in ILC was done.
  
  
  RESULTS
  The occurrence of multifocal (MFC) and multicentric carcinoma (MCC) was observed in 18.9% of ILC. Bilateral (BL) BCs were found to be statistically significantly more frequent in younger women, compared to those with MFC, MCC or nonMFC/MCC/BL. No significant correlation was found between MFC/MCC and the presence of axillary lymph node metastases, and expression of immunohistochemical predictive and prognostic parameters. Based on literature data and the findings from the current work, MFity/MCtiy might represent negative morphologic prognostic parameters in ILC.
  
  
  CONCLUSIONS
  In 334 cases analyzed, no statistically significant correlations were observed between MF/MC and the expression of immunohistochemical predictive and prognostic parameters.
authors.affiliation: Institute of Pathology, Faculty of Medicine, University of Niš, Niš, Serbia. Electronic address: ilicko81@gmail.com.
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Ilić
authors.affiliation: Department of Histology, Faculty of Medicine, University of Niš, Niš, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Petrović
authors.affiliation: Institute of Pathology, Faculty of Medicine, University of Niš, Niš, Serbia.
authors.forename: Vesna V
authors.initials: VV
authors.lastname: Živković
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Niš, Niš, Serbia.
authors.forename: Pavle J
authors.initials: PJ
authors.lastname: Randjelović
authors.affiliation: Faculty of Medicine, University of Niš, Niš, Serbia.
authors.forename: Nikola M
authors.initials: NM
authors.lastname: Stojanović
authors.affiliation: Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Niš, Serbia.
authors.forename: Niko S
authors.initials: NS
authors.lastname: Radulović
authors.affiliation: Pediatric Clinic, Clinical Center, Niš, Niš, Serbia.
authors.forename: Dušica
authors.initials: D
authors.lastname: Randjelović
authors.affiliation: Institute of Pathology, Faculty of Medicine, University of Niš, Niš, Serbia.
authors.forename: Ratko S
authors.initials: RS
authors.lastname: Ilić
mesh_terms: D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D015820:Cadherins / Q000378:metabolism; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000556:secondary*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015820:Cadherins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C513384:CDH1 protein, human
keywords: E-cadherin; Estrogen and progesterone receptors; HER-2; Invasive lobular carcinoma; Patient age