title: Relationship among body mass index, NT-proBNP, and mortality in decompensated chronic heart failure.
abstract: Obesity has been suggested to confer a survival benefit in acute heart failure. The concentrations of NT-proBNP may be reduced in patients with high body mass index (BMI).
  
  
  
  To investigate the relationship among BMI, NT-proBNP, and mortality risk in decompensated chronic heart failure (DCHF).
  
  
  
  This was a retrospective study. We studied 1001 patients with DCHF. Hazard ratios (HR) were calculated with Cox regression analysis.
  
  
  
  During the 1-year follow-up, 295 patients died. Compared with normal-weight patients, the unadjusted HR for death were 1.02 (95% CIs 0.79-1.33; p = 0.862) for patients with a BMI of 25.0-29.9 kg/m2and 0.83 (95% CIs 0.61-1.12; p = 0.213) for patients with a BMI ≥ 30 kg/m2. NT-proBNP remained independently associated with mortality across the BMI categories. There was no statistically significant interaction between BMI and NT-proBNP levels for risk prediction.
  
  
  
  Obesity was not associated with mortality risk. NT-proBNP remained an independent prognostic factor across the BMI categories.
authors.affiliation: Division of Cardiology and Cardiac Rehabilitation, "S. Maugeri" Foundation, IRCCS, Institute of Cassano Murge, Bari, Italy. Electronic address: domenico.scrutinio@fsm.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Scrutinio
authors.affiliation: Division of Cardiology and Cardiac Rehabilitation, "S. Maugeri" Foundation, IRCCS, Institute of Cassano Murge, Bari, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Passantino
authors.affiliation: Division of Cardiology and Cardiac Rehabilitation, "S. Maugeri" Foundation, IRCCS, Institute of Cassano Murge, Bari, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Guida
authors.affiliation: Cardiothoracic and Vascular Department, Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Ammirati
authors.affiliation: Cardiothoracic and Vascular Department, Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Oliva
authors.affiliation: "S. Maugeri" Foundation, IRCCS, Institute of Tradate, Varese, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Sarzi Braga
authors.affiliation: "S. Maugeri" Foundation, IRCCS, Institute of Montescano, Pavia, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: La Rovere
authors.affiliation: Division of Cardiology and Cardiac Rehabilitation, "S. Maugeri" Foundation, IRCCS, Institute of Cassano Murge, Bari, Italy.
authors.forename: Rocco
authors.initials: R
authors.lastname: Lagioia
authors.affiliation: Cardiothoracic and Vascular Department, Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Frigerio
authors.affiliation: Department of Emergency Medicine, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Di Somma
mesh_terms: D000368:Aged; D015992:Body Mass Index; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000150:complications / Q000401:mortality*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications*; D010446:Peptide Fragments / Q000097:blood*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Body mass index; Decompensated chronic heart failure; Mortality; Natriuretic peptides; Prognosis