title: Dual drug release from hydrogels covalently containing polymeric micelles that possess different drug release properties.
abstract: In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations to evaluate the profiles depicting the release of two compounds, rhodamine B and auramine O, from either polymeric micelles or hydrogels. According to our results, (1) hydrogels that covalently contains polymeric micelles that possess different drug release properties successfully exhibit the independent release behaviors of the two compounds and (2) fluorescence microscopy can greatly facilitate efforts to evaluate drug release properties of materials.
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Murata
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Uchida
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Takami
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Anzai
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Sonotaki
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan. Electronic address: muray@cc.tuat.ac.jp.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Murakami
mesh_terms: D001576:Benzophenoneidum / Q000737:chemistry*; D065546:Drug Liberation; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D008823:Micelles; D008856:Microscopy, Fluorescence; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D008823:Micelles; D011091:Polyesters; D012235:Rhodamines; D001576:Benzophenoneidum; D011092:Polyethylene Glycols; C033616:poly(lactide); C029773:rhodamine B
keywords: Dual drug release; Fluorescence observation; Hydrogel; Polymeric micelle