title: The role of the unfolded protein response in dengue virus pathogenesis.
abstract: Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. Host-viral interactions play a significant role in deciding the fate of the infection. The unfolded protein response (UPR) is a prosurvival cellular reaction induced in response to DENV-mediated endoplasmic reticulum stress. The UPR has complex interactions with the cellular autophagy machinery, apoptosis, and innate immunity. DENV has evolved to manipulate the UPR to facilitate its replication and to evade host immunity. Our knowledge of this intertwined network of events is continuously developing. A better understanding of the UPR mediated antiviral and proviral effects will shed light on dengue disease pathogenesis and may help development of anti-DENV therapeutics. This review summarizes the role of the UPR in viral replication, autophagy, and DENV-induced inflammation to describe how a host response contributes to DENV pathogenesis.
authors.affiliation: Antiviral Research Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.|Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
authors.forename: Nilanka
authors.identifier: 0000-0003-0154-1864
authors.initials: N
authors.lastname: Perera
authors.affiliation: Antiviral Research Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.
authors.forename: Joanna L
authors.identifier: 0000-0002-4383-4641
authors.initials: JL
authors.lastname: Miller
authors.affiliation: Antiviral Research Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.
authors.forename: Nicole
authors.identifier: 0000-0003-1969-4949
authors.initials: N
authors.lastname: Zitzmann
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D003715:Dengue / Q000276:immunology* / Q000473:pathology; D003716:Dengue Virus / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D056811:Unfolded Protein Response / Q000276:immunology*; D014779:Virus Replication
keywords: dengue; unfolded protein response; viruses (phages)