title: Disrupted Resting-State Default Mode Network in Betel Quid-Dependent Individuals.
abstract: Recent studies have shown that substance dependence (addiction) is accompanied with altered activity patterns of the default mode network (DMN). However, the neural correlates of the resting-state DMN and betel quid dependence (BQD)-related physiopathological characteristics still remain unclear. Resting-state functional magnetic resonance imaging images were obtained from 26 BQD individuals and 28 matched healthy control subjects. Group independent component analysis was performed to analyze the resting state images into spatially independent components. Gray matter volume was examined as covariate with voxel-based morphometry to rule out its effect on the functional results. The severity of BQD was assessed by the BQD Scale (BQDS). We observed decreased functional connectivity in anterior part of the DMN including ventral medial prefrontal cortex, orbital MPFC (OMPFC)/anterior cingulate cortex (ACC). Furthermore, the functional connectivity within the OMPFC/ACC in BQD individuals was negatively correlated with BQDS (p= 0.01,r= -0.49). We reported decreased functional connectivity within anterior part of the DMN in BQD individuals, which provides new evidence for the role of the DMN in the pathophysiology of BQD.
authors.affiliation: Health Management Center, Xiangya Hospital, Central South UniversityChangsha, China; School of Humanities and Social Sciences, National University of Defense TechnologyChangsha, China.
authors.forename: Xueling
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Obstetrics Department, Jinan Maternity and Child Care Hospital Jinan, China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Canhua
authors.initials: C
authors.lastname: Jiang
authors.affiliation: School of Humanities and Social Sciences, National University of Defense Technology Changsha, China.
authors.forename: Huaizhen
authors.initials: H
authors.lastname: Shen
authors.affiliation: School of Humanities and Social Sciences, National University of Defense Technology Changsha, China.
authors.forename: Furong
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Liao
authors.affiliation: Health Management Center, Xiangya Hospital, Central South UniversityChangsha, China; Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South UniversityChangsha, China.
authors.forename: Fulai
authors.initials: F
authors.lastname: Yuan
keywords: betel quid dependence; default mode network; fMRI; functional connectivity; independent component analysis; resting-state