title: [Local failures of nasopharynx carcinoma: Anatomoclinical aspects and therapeutic results].
abstract: OBJECTIVE
  Retrospective analysis of clinical aspects and therapeutic results of nasopharynx cancer local failures.
  
  
  METHODS
  Forty patients with local failure with or without nodal involvement of nasopharyngeal carcinoma were treated between 1993 and 2013. Reirradiation of nasopharynx was delivered at the dose of 60Gy. Platinum-based chemotherapy was indicated in case of locally advanced disease and/or associated nodal failure.
  
  
  RESULTS
  The mean age at diagnosis of primitive tumour was 41.9 years (26-67 years). The mean time of relapse occurrence was 31.7 months (6-104 months). Sixty five percent of failures were confined to the nasopharynx. Nodal failure was seen in 14 cases. Twenty-eight patients had chemotherapy. Twenty-five patients had reirradiation of nasopharynx. Mean follow-up was 98 months (12-191 months). Fourteen patients were still alive and in complete remission. Five-year survival was 40.7%. Xerostomia was the most frequent late toxicity. No haemorrhage was seen.
  
  
  CONCLUSIONS
  Reirradiation is the mainstay treatment of nasopharyngeal local failure. Late toxicity seems to decrease with novel techniques of reirradiation.
authors.affiliation: Service de radiothérapie carcinologique, CHU Habib-Bourguiba, université de Sfax, avenue Majida-Boulila, route El Ain, Sfax 3029, Tunisie. Electronic address: lilia.ghorbal@yahoo.fr.
authors.forename: L
authors.initials: L
authors.lastname: Ghorbal
authors.affiliation: Service de radiothérapie carcinologique, CHU Habib-Bourguiba, université de Sfax, avenue Majida-Boulila, route El Ain, Sfax 3029, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Elloumi
authors.affiliation: Service de radiothérapie carcinologique, CHU Habib-Bourguiba, université de Sfax, avenue Majida-Boulila, route El Ain, Sfax 3029, Tunisie.
authors.forename: W
authors.initials: W
authors.lastname: Siala
authors.affiliation: Service d'anatomopathologie, CHU Habib-Bourguiba, université de Sfax, Sfax 3029, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Khabir
authors.affiliation: Service d'ORL, CHU Habib-Bourguiba, université de Sfax, Sfax 3029, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Ghorbel
authors.affiliation: Service de carcinologie médicale, CHU Habib-Bourguiba, université de Sfax, Sfax 3029, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Frikha
authors.affiliation: Service de radiothérapie carcinologique, CHU Habib-Bourguiba, université de Sfax, avenue Majida-Boulila, route El Ain, Sfax 3029, Tunisie.
authors.forename: J
authors.initials: J
authors.lastname: Daoud
mesh_terms: D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D010026:Osteosclerosis / Q000453:epidemiology / Q000209:etiology; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012189:Retrospective Studies; D016879:Salvage Therapy; D016896:Treatment Outcome; D014987:Xerostomia / Q000453:epidemiology / Q000209:etiology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D009944:Organoplatinum Compounds
keywords: Cancer; Failure; Local; Nasopharynx; Récidive; Traitement; Treatment