title: Epigallocatechin gallate: A useful therapy for cognitive disability in Down syndrome?
abstract: Neurodevelopmental alterations and cognitive disability are constant features of Down syndrome (DS), a genetic condition due to triplication of chromosome 21.DYRK1Ais one of the triplicated genes that is thought to be strongly involved in brain alterations. Treatment of Dyrk1A transgenic mice with epigallocatechin gallate (EGCG), an inhibitor of DYRK1A, improves cognitive performance, suggesting that EGCG may represent a suitable treatment of DS. Evidence in the Ts65Dn mouse model of DS shows that EGCG restores hippocampal development, although this effect is ephemeral. Other studies, however, show no effects of treatment on hippocampus-dependent memory. On the other hand, a pilot study in young adults with DS shows that EGCG transiently improves some aspects of memory. Interestingly, EGCG plus cognitive training engenders effects that are more prolonged. Studies in various rodent models show a positive impact of EGCG on brain and behavior, but other studies show no effect. In spite of these discrepancies, possibly due to heterogeneity of protocols/timing/species, EGCG seems to exert some beneficial effects on the brain. It is possible that protocols of periodic EGCG administration to individuals with DS (alone or in conjunction with other treatments) may prevent the disappearance of its effects.
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna, Italy.
authors.forename: Fiorenza
authors.initials: F
authors.lastname: Stagni
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Giacomini
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Emili
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Guidi
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Ciani
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna, Italy.
authors.forename: Renata
authors.initials: R
authors.lastname: Bartesaghi
keywords: Down syndrome; EGCG; cognitive performance; mouse models; neurodevelopmental alterations; therapy