title: Long-term cardiac (valvulopathy) safety of cabergoline in prolactinoma.
abstract: BACKGROUND
  Clinical relevance of association of cabergoline use for hyperprolactinemia and cardiac valvulopathy remains unclear.
  
  
  OBJECTIVE
  The aim of the study was to determine the prevalence of valvular heart abnormalities in patients taking cabergoline for the treatment of prolactinoma and to explore any associations with the cumulative dose of drug used.
  
  
  METHODS
  A cross-sectional echocardiographic study was performed in patients who were receiving cabergoline therapy for prolactinoma.
  
  
  RESULTS
  Hundred (61 females, 39 males) prolactinoma cases (81 macroprolactinoma and 19 microprolactinoma) were included in the study. The mean age at presentation was 33.9 ± 9.0 years (range: 16-58 years). The mean duration of treatment was 53.11 ± 43.15 months (range: 12-155 months). The mean cumulative dose was 308.6 ± 290.2 mg (range: 26-1196 mg; interquartile range: 104-416 mg). Mild mitral regurgitation was present in one patient (cumulative cabergoline dose 104 mg). Mild tricuspid regurgitation was present in another two patients (cumulative cabergoline dose 52 mg and 104 mg). Aortic and pulmonary valve functioning was normal in all the cases. There were no cases of significant valvular regurgitation (moderate to severe, Grade 3-4). None of the patients had morphological abnormalities such as thickening, calcification, and restricted mobility of any of the cardiac valves.
  
  
  CONCLUSIONS
  Cabergoline appears to be safe in patients with prolactinoma up to the cumulative dose of ~300 mg. The screening for valvulopathy should be restricted to those with higher cumulative cabergoline exposure.
authors.affiliation: Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India.
authors.forename: Shruti
authors.initials: S
authors.lastname: Khare
authors.affiliation: Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India.
authors.forename: Anurag R
authors.initials: AR
authors.lastname: Lila
authors.affiliation: Department of Cardiology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India.
authors.forename: Rishikesh
authors.initials: R
authors.lastname: Patil
authors.affiliation: Department of Cardiology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India.
authors.forename: Milind
authors.initials: M
authors.lastname: Phadke
authors.affiliation: Department of Cardiology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India.
authors.forename: Prafulla
authors.initials: P
authors.lastname: Kerkar
authors.affiliation: Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India.
authors.forename: Tushar
authors.initials: T
authors.lastname: Bandgar
authors.affiliation: Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India.
authors.forename: Nalini S
authors.initials: NS
authors.lastname: Shah
keywords: Cabergoline; prolactinoma; valvulopathy