title: Acute toxicity, twenty-eight days repeated dose toxicity and genotoxicity of vanadyl trehalose in kunming mice.
abstract: A new trend has been developed using vanadium and organic ligands to form novel compounds in order to improve the beneficial actions and reduce the toxicity of vanadium compounds. In present study, vanadyl trehalose was explored the oral acute toxicity, 28 days repeated dose toxicity and genotoxicity in Kunming mice. The Median Lethal Dose (LD50) of vanadyl trehalose was revealed to be 1000 mg/kg body weight in fasted Kunming mice. Stomach and intestine were demonstrated to be the main target organs of vanadyl trehalose through 28 days repeated dose toxicity study. And vanadyl trehalose also showed particular genotoxicity through mouse bone marrow micronucleus and mouse sperm malformation assay. In brief, vanadyl trehalose presented certain, but finite toxicity, which may provide experimental basis for the clinical application.
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Pingzhe
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Zaizhong
authors.initials: Z
authors.lastname: Ni
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Tianjin Children's Hospital, 300074, Tianjin, China.
authors.forename: Baicheng
authors.initials: B
authors.lastname: Ma
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Huikun
authors.initials: H
authors.lastname: Duan
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ma
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Xiangzhen
authors.initials: X
authors.lastname: Ji
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Qiqi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Xing
authors.affiliation: Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, 300071, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, 300071, Tianjin, China. Electronic address: mgl@nankai.edu.cn.
authors.forename: Minggang
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D005260:Female; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D023382:Toxicity Tests, Acute; D059551:Toxicity Tests, Subacute; D014199:Trehalose / Q000633:toxicity*; D017968:Vanadium Compounds / Q000633:toxicity*
chemical_list: D009153:Mutagens; D017968:Vanadium Compounds; D014199:Trehalose
keywords: Acute toxicity; Genotoxicity; Kunming mice; Twenty-eight days repeated dose toxicity; Vanadium; Vanadyl trehalose